DRUG NAME: Etoposide - BC Cancer
Etoposide
DRUG NAME: Etoposide
SYNONYM(S): VP-161
COMMON TRADE NAME: VEPESID?, ETOPOPHOS? (etoposide phosphate)
CLASSIFICATION: topoisomerase II inhibitor1
Special pediatric considerations are noted when applicable, otherwise adult provisions apply.
MECHANISM OF ACTION:
Etoposide is a semisynthetic derivative of the podophyllotoxins, an epipodophyllotoxin. It inhibits DNA
topoisomerase II, thereby inhibiting DNA synthesis. Etoposide is cell cycle dependent and phase specific, affecting
1
mainly the S and G2 phases.
PHARMACOKINETICS:
Interpatient variability
bioavailability
Oral Absorption
dose-dependent; absorption decreases as etoposide dose increases; mean 50%.
daily doses greater than 200 mg should be divided (BID)
absorption does not appear to be altered by food or changes in stomach pH and
2
emptying ; however manufacturer recommends drug be taken on an empty stomach.
time to peak plasma
1-1.5 h
concentration
detected in saliva, liver, spleen, kidney, myometrium, healthy brain tissue, and brain
tumour tissue, minimally in pleural fluid
1
cross blood brain barrier?
in low and variable concentrations
Distribution
1
2
volume of distribution
plasma protein binding
Metabolism
7-17 L/m , 32% of body weight
3
95%
1
hepatic biotransformation
1
active metabolite
1
Excretion
yes
inactive metabolite
fecal and urinary excretion
yes
urine
feces
44-60% (67% of that unchanged)
1
up to 16% (as unchanged drug and metabolites)
biliary
terminal half life
................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related download
- nutritional guidelines for symptom management mucositis
- diagnosis and management of upper gastrointestinal
- drug name etoposide bc cancer
- treatment guide swallowing and esophageal disorders
- gerd a practical approach
- dyspepsia primary care pathway alberta health services
- alcohol s role in gastrointestinal tract disorders
- anticholinergics reference list
- less known gastrointestinal manifestations of drug
- support for people with cancer eating hints
Related searches
- bc english 12 original composition
- bc provincial exam essay example
- bc provincial exam sample essay
- bc english 12 composition
- bc grade 12 english exam
- bc provincial exam
- bc english 12 provincial exam
- bc gov high school transcript
- canada bc english provincial exam
- new cancer drug breakthrough 2019
- brand name drug generic equivalent
- new cancer drug approvals 2019