Lung Cancer Basic Overview Patient Forum: 2020
Lung Cancer Basic Overview Patient Forum: 2020
Corey J Langer MD, FACP Director of Thoracic Oncology
Abramson Cancer Center Professor of Medicine
University of Pennsylvania Philadelphia, PA 19104
What everyone should know about Lung Cancer
? World-wide Epidemic ? It is a largely preventable illness
? Eliminating smoking could prevent ~150,000 cases annually in the US ? in 20-40 years time
? Increasing percentage of those diagnosed are non-smokers or remote former smokers (> 20%)
? Different biology and clinical behavior; higher incidence of mutations and other molecular markers
? Cure rates remain disappointing, although we've seen major improvements over the past 30 yrs, especially the past 5-10 years thanks to screening, targeted therapy and immunotherapy
? Pro-active, supportive care may yield as much survival benefit as toxic, systemic therapy
? Clinical and translational research is the key to improving survival rates ? Best outcomes occur in the setting of a multi-disciplinary, collaborative partnership
with good logistical access
Multidisciplinary approach: Penn
Pulmonary
Albelda, Haas, Thompson, Moon, Lanfranco, Vachani, Ma, Dibardino
Medical Oncology
Langer, Aggarwal, Cohen, Bauml, Ciunci, Singh, Kosteva, Marmarelis, Davella, Costello,
Kerr, Sun, Davis, Jeffries
Thoracic Surgery
Singhal, Kucharczuk, Pechet, Jarrar
Pathology Lab Medicine
Deshpande, Litzky, Zhang, Plesa, Feldman, Roth, Morrissette, Carpenter
TCE in Thoracic Oncology: Penn
Radiology
Katz, Kolansky, Hunt
Basic/Translational Science
Albelda, June, Hancock, Linette, Beatty, Carreno, Wherry, Huang, Eruslanov
Radiation Oncology
Berman, Feigenberg, Swisher-McClure, Levin, Chen, Gabriel, Doucette
Oncology Informatics
Gabriel, Doucette
Biostatistics Epidemiology
Mick, Hwang
Multidisciplinary approach: Penn
Pulmonary
Albelda, Haas, Thompson, Moon, Lanfranco, Vachani, Ma, Dibardino
Medical Oncology
Langer, Aggarwal, Cohen, Bauml, Ciunci, Singh, Kosteva, Marmarelis, Sun, Davis, Jeffries
Thoracic Surgery
Singhal, Kucharczuk, Pechet, Jarrar
Pathology Lab Medicine
Deshpande, Litzky, Zhang, Plesa, Feldman, Roth, Morrissette, Carpenter
TCE in Thoracic Oncology: Penn
Radiology
Katz, Kolansky, Hunt
Basic/Translational Science
Albelda, June, Hancock, Linette, Beatty, Carreno, Wherry, Huang, Eruslanov
Radiation Oncology
Berman, Feigenberg, Swisher-McClure, Levin, Chen, Gabriel, Doucette
Oncology Informatics
Gabriel, Doucette
Biostatistics Epidemiology
Mick, Hwang
Lung Cancer: Overview
Research is underfunded (compared to other cancers, e.g. breast cancer)
Early detection makes a difference
The NLST proved this In at risk individuals, low dose spiral CTs detected lung cancers
earlier than conventional CXRs, when they were more curable; this led to a decrease in lung cancer mortality NELSON trial from Europe proved confirmatory
Types of lung cancer have changed over past 40 years
? Non?small cell lung cancer (NSCLC): 75% 87% ? Small cell lung cancer (SCLC): 25% 13%
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