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Development of a measure of multiple physical environmental deprivation. After United Kingdom and New Zealand, Portugal. Citation for published version: Ribeiro, AI, de Fátima de Pina, M, and Mitchell, R (2015) ‘Development of a measure of multiple physical environmental deprivation. After United Kingdom and New Zealand, Portugal.’ European Journal of Public Health. ? Object Identifier (DOI): ?: Link to paper online Version: Author final version (often known as postprint) Published In: European Journal of Public Health Publisher Rights Statement: Published in the European Journal of Public Health by Oxford University Press (2015)This is the author’s final draft as submitted for publication. The final version was published in the European Journal of Public Health by Oxford University Press on behalf of the European Public Health Association (2015). Cite As: Ribeiro, AI, de Fátima de Pina, M, and Mitchell, R (2015) ‘Development of a measure of multiple physical environmental deprivation. After United Kingdom and New Zealand, Portugal.’ European Journal of Public Health. ? Development of a measure of multiple physical environmental deprivation. After United Kingdom and New Zealand, Portugal.Ana Isabel Ribeiro, MS1,2,3, Maria de Fátima de Pina, PhD1,2,3, Richard Mitchell, PhD41INEB – Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal;2Departamento de Epidemiologia Clínica, Medicina Preditiva e Saúde Pública, Faculdade de Medicina, Universidade do Porto, Porto, Portugal; 3ISPUP – Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal;4Centre for Population Health Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UKAna Isabel Correia Ribeiro*Corresponding author. GeoEpidemiology Group, Instituto de Engenharia Biomédica - INEB, Universidade do PortoRua do Campo Alegre, 8234150-180 Porto Tel: +351 226074900 Fax: +351 226094567E-mail: ana.isabel.ribeiro@ineb.up.ptMaria de Fátima de PinaGeoEpidemiology Group, Departamento de Epidemiologia Clínica, Medicina Preditiva e Saúde Pública, Faculdade de Medicina, Universidade do Porto, PortugalAlameda Prof. Hern?ni Monteiro4200-319 PortoTel: +351 225513652Fax: +351 225513653E-mail: fpina@med.up.ptRichard MitchellCentre for Research on Environment, Society and HealthCollege of Medical, Veterinary and Life Sciences, University of Glasgow1 Lilybank GardensGlasgow G12 8RZTel: +44 (0) 1413301663E-mail: Richard.Mitchell@glasgow.ac.ukAbstract word count: 250 wordsManuscript word count: 3368 words (without tables, figure legends, abstract and references)Abstract:Background: Spatial inequalities in health have been identified but the contribution of physical environment has been largely ignored. In Portugal, strong spatial differences in morbidity and mortality remain unexplained. Based on previous United Kingdom (UK) and New Zealand (NZ) research, we aimed to develop a Portuguese measure of multiple environmental deprivation (PT-MEDIx) to assist in understanding spatial inequalities in health. Methods: PT-MEDIx was built at municipality-level in four stages: 1) identify health-relevant environmental factors; 2) acquire datasets about selected environmental factors and calculate municipality-level measures using Geographical Information Systems; 3) test associations between selected environmental factors and mortality using negative binomial models, adjusting for age, sex, socioeconomic deprivation and interactions; 4) construct a summary measure and assess its association with mortality. Results: We included five dimensions of the physical environment: air pollution, climate, drinking water quality, green space availability and industry proximity. PT-MEDIx score ranged from -1 (least environmental deprivation) to +4 (most) and depicted a clear spatial pattern: least deprived municipalities in the depopulated rural areas and most deprived in urban and industrial settings. Comparing with those in the intermediate category of environment deprivation, less deprived municipalities showed lower mortality rate ratios (MRRs) and vice-versa: MRRs for all-cause mortality were 0.962 [95% confidence interval 0.934-0.991] and 1.209 [1.086-1.344], in the least and most deprived municipalities respectively, and for cancer, 0.957 [0.911-1.006] and 1.345 [1.123-1.598]. Conclusions: The methods used to create UK&NZ indexes have good transferability to Portugal. MEDIx might contribute to untangle the complex pathways that link health, socioeconomic and physical environment.Key-words: Portugal, health inequalities, environmental deprivation index, mortality, Geographic Information SystemsIntroductionSpatial inequalities in health and health-related behaviors have been identified worldwide ADDIN EN.CITE <EndNote><Cite><Author>van Lenthe</Author><Year>2007</Year><RecNum>286</RecNum><DisplayText>(1)</DisplayText><record><rec-number>286</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">286</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>van Lenthe, Frank J.</author><author>Martikainen, Pekka</author><author>Mackenbach, Johan P.</author></authors></contributors><titles><title>Neighbourhood inequalities in health and health-related behaviour: Results of selective migration?</title><secondary-title>Health & Place</secondary-title></titles><periodical><full-title>Health Place</full-title><abbr-1>Health & place</abbr-1></periodical><pages>123-137</pages><volume>13</volume><number>1</number><keywords><keyword>Neighbourhood</keyword><keyword>Socioeconomic inequality</keyword><keyword>Health</keyword><keyword>Migration</keyword></keywords><dates><year>2007</year><pub-dates><date>3//</date></pub-dates></dates><isbn>1353-8292</isbn><urls><related-urls><url>;(1). Reducing health inequalities is currently a political priority ADDIN EN.CITE <EndNote><Cite><Author>Woodward</Author><Year>2000</Year><RecNum>303</RecNum><DisplayText>(2)</DisplayText><record><rec-number>303</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">303</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Woodward, A.</author><author>Kawachi, I.</author></authors></contributors><auth-address>Department of Public Health, Wellington School of Medicine, PO Box 7343 Wellington South, New Zealand. woodward@wnmeds.ac.nz</auth-address><titles><title>Why reduce health inequalities?</title><secondary-title>J Epidemiol Community Health</secondary-title><alt-title>Journal of epidemiology and community health</alt-title></titles><periodical><full-title>J Epidemiol Community Health</full-title><abbr-1>Journal of epidemiology and community health</abbr-1></periodical><alt-periodical><full-title>J Epidemiol Community Health</full-title><abbr-1>Journal of epidemiology and community health</abbr-1></alt-periodical><pages>923-9</pages><volume>54</volume><number>12</number><edition>2000/11/15</edition><keywords><keyword>Cost-Benefit Analysis</keyword><keyword>Cultural Characteristics</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Public Health/economics</keyword><keyword>Social Class</keyword><keyword>Social Conditions/economics</keyword><keyword>Socioeconomic Factors</keyword></keywords><dates><year>2000</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>0143-005X (Print)
0143-005X (Linking)</isbn><accession-num>11076989</accession-num><urls></urls><custom2>PMC1731601</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>(2) yet spatial inequalities in health are widening rather than narrowing ADDIN EN.CITE <EndNote><Cite><Author>Richardson</Author><Year>2013</Year><RecNum>285</RecNum><DisplayText>(3)</DisplayText><record><rec-number>285</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">285</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Richardson, E. A.</author><author>Pearce, J.</author><author>Mitchell, R.</author><author>Shortt, N. K.</author><author>Tunstall, H.</author></authors></contributors><auth-address>1 Centre for Research on Environment, Society and Health (CRESH), Research Institute of Geography and the Lived Environment, School of GeoSciences, University of Edinburgh, Edinburgh EH8 9XP, UK.</auth-address><titles><title>Have regional inequalities in life expectancy widened within the European Union between 1991 and 2008?</title><secondary-title>Eur J Public Health</secondary-title><alt-title>European journal of public health</alt-title></titles><periodical><full-title>Eur J Public Health</full-title><abbr-1>European journal of public health</abbr-1></periodical><alt-periodical><full-title>Eur J Public Health</full-title><abbr-1>European journal of public health</abbr-1></alt-periodical><edition>2013/07/03</edition><dates><year>2013</year><pub-dates><date>Jun 27</date></pub-dates></dates><isbn>1464-360X (Electronic)
1101-1262 (Linking)</isbn><accession-num>23813717</accession-num><urls></urls><electronic-resource-num>10.1093/eurpub/ckt084</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>Eng</language></record></Cite></EndNote>(3). However, individual-level characteristics and area-level socioeconomic differentials are far from being the whole explanation for them. Physical environment might be a key determinant of the spatial distribution of health and disease ADDIN EN.CITE <EndNote><Cite><Author>Ezzati</Author><Year>2002</Year><RecNum>311</RecNum><DisplayText>(4)</DisplayText><record><rec-number>311</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">311</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ezzati, Majid</author><author>Lopez, Alan D.</author><author>Rodgers, Anthony</author><author>Vander Hoorn, Stephen</author><author>Murray, Christopher J. L.</author></authors></contributors><titles><title>Selected major risk factors and global and regional burden of disease</title><secondary-title>The Lancet</secondary-title></titles><periodical><full-title>The Lancet</full-title></periodical><pages>1347-1360</pages><volume>360</volume><number>9343</number><dates><year>2002</year></dates><isbn>0140-6736</isbn><urls><related-urls><url>;(4). However, it has been often ignored by research on inequalities. Where it has been included, the focus has tended to be on harmful factors (e.g. pollution, climate extremes) ignoring the beneficial ones (e.g. green space, mild climate). Also, researchers have typically analyzed single exposures, ignoring the fact that pathogenic exposures rarely occur in isolation, and have mostly considered acute effects, overlooking the potential chronic effects PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW5ncmlzaDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+
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ADDIN EN.CITE.DATA (5). We hypothesize that a wide range of harmful and beneficial factors, interacting with each other and with socioeconomic, cultural and individual characteristics, might shape the geographies of health.Recently, researchers from United Kingdom (UK) and New Zealand (NZ) looked at the implications of physical environmental for spatial inequalities in health. They followed the principles used to build well-known socioeconomic deprivation indexes – England ADDIN EN.CITE <EndNote><Cite><Year>2011</Year><RecNum>327</RecNum><DisplayText>(6)</DisplayText><record><rec-number>327</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">327</key></foreign-keys><ref-type name="Report">27</ref-type><contributors></contributors><titles><title>The English Indices of Deprivation 2010</title></titles><dates><year>2011</year></dates><pub-location>London</pub-location><publisher>Department for Communities and Local Government</publisher><urls></urls></record></Cite></EndNote>(6), Scotland ADDIN EN.CITE <EndNote><Cite><Year>2012</Year><RecNum>326</RecNum><DisplayText>(7)</DisplayText><record><rec-number>326</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">326</key></foreign-keys><ref-type name="Report">27</ref-type><contributors></contributors><titles><title>Scottish Index of Multiple Deprivation 2012. A National Statistics Publication for Scotland</title></titles><dates><year>2012</year></dates><pub-location>Edinburgh</pub-location><publisher>The Scottish Government</publisher><urls></urls></record></Cite></EndNote>(7), Wales ADDIN EN.CITE <EndNote><Cite><Year>2011</Year><RecNum>330</RecNum><DisplayText>(8)</DisplayText><record><rec-number>330</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">330</key></foreign-keys><ref-type name="Report">27</ref-type><contributors></contributors><titles><title>Welsh Index of Multiple Deprivation 2011</title></titles><dates><year>2011</year></dates><pub-location>Cardiff</pub-location><publisher>Welsh Government</publisher><urls></urls></record></Cite></EndNote>(8) and Northern Ireland ADDIN EN.CITE <EndNote><Cite><Year>2010</Year><RecNum>331</RecNum><DisplayText>(9)</DisplayText><record><rec-number>331</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">331</key></foreign-keys><ref-type name="Report">27</ref-type><contributors></contributors><titles><title>Northern Ireland Multiple Deprivation Measure 2010</title></titles><dates><year>2010</year></dates><pub-location>Belfast</pub-location><publisher>Northern Ireland Statistics and Research Agency</publisher><urls></urls></record></Cite></EndNote>(9) indices of multiple deprivation, which recently started to integrate variables of the physical environment such as air pollution, as well as Carstairs ADDIN EN.CITE <EndNote><Cite><Author>Carstairs</Author><Year>1989</Year><RecNum>320</RecNum><DisplayText>(10)</DisplayText><record><rec-number>320</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">320</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Carstairs, V.</author><author>Morris, R.</author></authors></contributors><auth-address>Department of Community Medicine, Medical School, Edinburgh.</auth-address><titles><title>Deprivation: explaining differences in mortality between Scotland and England and Wales</title><secondary-title>BMJ</secondary-title><alt-title>BMJ (Clinical research ed.)</alt-title></titles><periodical><full-title>BMJ</full-title></periodical><pages>886-9</pages><volume>299</volume><number>6704</number><edition>1989/10/07</edition><keywords><keyword>Automobiles</keyword><keyword>England/epidemiology</keyword><keyword>Female</keyword><keyword>Health Status Indicators</keyword><keyword>Housing</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Mortality</keyword><keyword>Scotland/epidemiology</keyword><keyword>Social Class</keyword><keyword>Socioeconomic Factors</keyword><keyword>Unemployment</keyword><keyword>Wales/epidemiology</keyword></keywords><dates><year>1989</year><pub-dates><date>Oct 7</date></pub-dates></dates><isbn>0959-8138 (Print)
0959-535X (Linking)</isbn><accession-num>2510878</accession-num><urls></urls><custom2>PMC1837760</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>(10) and Townsend ADDIN EN.CITE <EndNote><Cite><Author>Townsend</Author><Year>1988</Year><RecNum>321</RecNum><DisplayText>(11)</DisplayText><record><rec-number>321</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">321</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Townsend, P</author><author>Phillimore, P</author><author>Beattie, A</author></authors><secondary-authors><author>Routledge</author></secondary-authors></contributors><titles><title>Health and Deprivation: Inequality and the North.</title></titles><dates><year>1988</year></dates><pub-location>London</pub-location><urls></urls></record></Cite></EndNote>(11). The outcome was the creation of the Multiple Environmental Deprivation Indexes (MEDIx) specific to UK and to NZ PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaG9ydHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA (12-17). These indexes, together with socioeconomic deprivation, contributed to a better understanding of spatial inequalities in health within these countries. Indeed growing evidence suggests the effect of socioeconomic and environmental deprivation on health inequalities cannot be detached; they need to be studied within an ‘environmental justice’ framework to assess whether most socioeconomically deprived populations are exposed to harmful physical environments and vice-versa ADDIN EN.CITE <EndNote><Cite><Author>Lee</Author><Year>2002</Year><RecNum>332</RecNum><DisplayText>(18)</DisplayText><record><rec-number>332</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">332</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lee, C.</author></authors></contributors><auth-address>Office of Environmental Justice, U.S. Environmental Protection Agency, Washington, DC, USA. lee.charles@</auth-address><titles><title>Environmental justice: building a unified vision of health and the environment</title><secondary-title>Environ Health Perspect</secondary-title><alt-title>Environmental health perspectives</alt-title></titles><periodical><full-title>Environ Health Perspect</full-title><abbr-1>Environmental health perspectives</abbr-1></periodical><alt-periodical><full-title>Environ Health Perspect</full-title><abbr-1>Environmental health perspectives</abbr-1></alt-periodical><pages>141-4</pages><volume>110 Suppl 2</volume><edition>2002/04/04</edition><keywords><keyword>Environmental Health</keyword><keyword>Environmental Pollutants/ adverse effects</keyword><keyword>Humans</keyword><keyword>Liability, Legal</keyword><keyword>Minority Groups</keyword><keyword>Policy Making</keyword><keyword>Poverty</keyword><keyword>Public Policy</keyword><keyword>Social Class</keyword></keywords><dates><year>2002</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0091-6765 (Print)
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ADDIN EN.CITE.DATA (20-23). Nevertheless, the strong regional differences in diseases, such as coronary heart disease, remain partially unexplained, possibly due to the restricted diversity (mostly economic and health resources) of the explanatory variables that have been considered ADDIN EN.CITE <EndNote><Cite><Author>Ferreira-Pinto</Author><Year>2012</Year><RecNum>281</RecNum><DisplayText>(20)</DisplayText><record><rec-number>281</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">281</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ferreira-Pinto, L. M.</author><author>Rocha-Goncalves, F.</author><author>Teixeira-Pinto, A.</author></authors></contributors><auth-address>CINTESIS, Faculty of Medicine, University of Porto, Porto, Portugal.</auth-address><titles><title>An ecological study on the geographic patterns of ischaemic heart disease in Portugal and its association with demography, economic factors and health resources distribution</title><secondary-title>BMJ Open</secondary-title><alt-title>BMJ open</alt-title></titles><periodical><full-title>BMJ Open</full-title><abbr-1>BMJ open</abbr-1></periodical><alt-periodical><full-title>BMJ Open</full-title><abbr-1>BMJ open</abbr-1></alt-periodical><volume>2</volume><number>4</number><edition>2012/07/05</edition><dates><year>2012</year></dates><isbn>2044-6055 (Electronic)</isbn><accession-num>22761279</accession-num><urls></urls><custom2>PMC3391373</custom2><electronic-resource-num>10.1136/bmjopen-2011-000595</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>(20). Based on the research from the UK and NZ, we aimed to develop a Portuguese measure of multiple environmental deprivation (PT-MEDIx). Our aim was also to assess how the choice of the environmental factors, datasets and methods of analysis should be adapted to the Portuguese idiosyncrasies without compromising comparability. This paper describes how the PT-MEDIx was created, and how it is associated with risk of mortality in Portugal.MethodsThe development of PT-MEDIx followed the precedent set by the UK and NZ indexes, and therefore had four stages PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZWFyY2U8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA (12-17):Identify health-relevant environmental factors for Portugal;Acquire and prepare datasets of such environmental factors;Test associations between the environmental factors and health;Construct the summary measure and assess its associations with health.The term environmental deprivation refers to physical environment that surrounds population and that includes external physical (e.g. climate), chemical (e.g. pollution) and biological (e.g. greenness) factors; social and cultural factors were excluded ADDIN EN.CITE <EndNote><Cite><Author>Richardson</Author><Year>2009</Year><RecNum>283</RecNum><DisplayText>(13)</DisplayText><record><rec-number>283</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">283</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Richardson, E. A.</author><author>Mitchell, R. J.</author><author>Shortt, N. K.</author><author>Pearce, J.</author><author>Dawson, T. P.</author></authors></contributors><auth-address>The University of Edinburgh, UK. e.richardson@ed.ac.uk</auth-address><titles><title>Evidence-based selection of environmental factors and datasets for measuring multiple environmental deprivation in epidemiological research</title><secondary-title>Environ Health</secondary-title><alt-title>Environmental health : a global access science source</alt-title></titles><periodical><full-title>Environ Health</full-title><abbr-1>Environmental health : a global access science source</abbr-1></periodical><alt-periodical><full-title>Environ Health</full-title><abbr-1>Environmental health : a global access science source</abbr-1></alt-periodical><pages>S18</pages><volume>8 Suppl 1</volume><edition>2010/02/05</edition><keywords><keyword>Data Collection</keyword><keyword>Environment</keyword><keyword>Environmental Pollution/ analysis/statistics & numerical data</keyword><keyword>Epidemiologic Measurements</keyword><keyword>Evidence-Based Practice</keyword><keyword>Great Britain</keyword><keyword>Humans</keyword><keyword>Program Development</keyword></keywords><dates><year>2009</year></dates><isbn>1476-069X (Electronic)
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ADDIN EN.CITE.DATA (13, 16). Whilst rather arbitrary, it nonetheless ensures that the included factors affect a reasonable proportion?of?the national population. In the UK work, for example, the threshold led to the exclusion of radon exposure, which affects a small and spatially restricted proportion of the UK population.To identify which factors were related to health an extensive literature review was conducted on key bibliographic databases – Pubmed and WebOfKnowledge, for studies about:Climate;Traffic air pollution;Industrial pollution;Drinking water quality;Ionizing radiation: ultraviolet B radiation (UVB) and radon;Green space;Noise.We also sought Portuguese and Southern European-specific studies of the relationships between these factors and health.Exposure to non-ionizing radiation (extremely low and radio frequencies) is rare in Portugal (<0.5% of the population), so we did not review the literature on that topic. We also excluded contaminated land, as datasets describing its distribution were unavailable. A table summarizing the epidemiological evidence about the health impact of each factor can be found as supplementary material (see supplementary table S1). Full reviews were written and are available from CRESH (Centre for Research on Environment Society and Health) and ISPUP (Institute of Public Health, University of Porto) websites ADDIN EN.CITE <EndNote><Cite><RecNum>324</RecNum><DisplayText>(24, 25)</DisplayText><record><rec-number>324</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">324</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors></contributors><titles><title>Centre for Research on Environment Society and Health </title></titles><dates></dates><urls><related-urls><url> app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">325</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors></contributors><titles><title>Instituto de Saúde Pública da Universidade do Porto</title></titles><dates></dates><urls><related-urls><url>;(24, 25). Stage 2 – Acquire and process datasets about the selected environmental factorsPortugal mainland territory is divided into 278 municipalities (average population=36,000), which are subdivided in parishes (average population=2500). The studies from UK and NZ were grounded in small geographic units: census area statistics wards (UK) and census area units (NZ). PT-MEDIx was constructed at municipality level because: 1) parish boundaries change frequently; 2) socio-demographic data at parish-level are available only for census years; 3) mortality and health data are difficult to obtain at parish-level due to confidentiality and, when accessible, they lack completeness and quality. To ensure our results were not biased by this decision, we replicated the study at parish level as far as possible. Key results remained unchanged. We included only Portuguese-wide datasets, likely to be regularly updated, complete and of good quality. No country-wide dataset on noise exposure was found, leading to its exclusion. Similarly, no complete dataset on the duration of heat-waves or cold spells was found. However, the distribution of the duration of extreme temperature events follows the geographical pattern of mean temperatures ADDIN EN.CITE <EndNote><Cite><Year>2011</Year><RecNum>315</RecNum><DisplayText>(26)</DisplayText><record><rec-number>315</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">315</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><secondary-authors><author>Departamento de Producción da Agência Estatal de Meteorologia de Espanha (?rea de Climatología y Aplicaciones Operativas) & Departamento de Meteorologia e Clima (Divis?o de Observa??o Meteorológica e Clima), do Instituto de Meteorologia – Portugal</author></secondary-authors><tertiary-authors><author>Departamento de Producción da Agência Estatal de Meteorologia de Espanha (?rea de Climatología y Aplicaciones Operativas) & Departamento de Meteorologia e Clima (Divis?o de Observa??o Meteorológica e Clima), do Instituto de Meteorologia – Portugal</author></tertiary-authors></contributors><titles><title>Iberian Climate Atlas - Air temperature and precipitation (1971-2000)</title></titles><dates><year>2011</year></dates><publisher>Departamento de Producción da Agência Estatal de Meteorologia de Espanha (?rea de Climatología y Aplicaciones Operativas) & Departamento de Meteorologia e Clima (Divis?o de Observa??o Meteorológica e Clima), do Instituto de Meteorologia – Portugal</publisher><urls></urls></record></Cite></EndNote>(26). Available data on indoor radon exposure had outdated an inadequate geographical coverage; therefore, was not considered. As almost all datasets were available for 2006, we centered our study around that year. Table 1 describes the datasets used, and the measures derived from them. Using a Geographical Information System (GIS), ArcGIS 10.2, we rendered each environmental dataset to municipalities. We calculated population-weighted means at municipality level to account for the unequal distribution of residents. An Europe-wide 1 km population grid ADDIN EN.CITE <EndNote><Cite><Year>2006</Year><RecNum>277</RecNum><DisplayText>(27)</DisplayText><record><rec-number>277</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">277</key></foreign-keys><ref-type name="Online Database">45</ref-type><contributors></contributors><titles><title>GEOSTAT 1km2 population grid</title></titles><dates><year>2006</year></dates><pub-location>Luxembourg</pub-location><publisher>GEOSTAT, Eurostat JRC, European Commission</publisher><urls><related-urls><url>;(27) was used to calculate population-weighted exposures of air pollution, nitrates in private water supplies, climate and UVB radiation.Data for trihalometanes (THM) in drinking water were already provided by municipality. To assess proximity to industries, a 3 km buffer (median radius found in the reviewed literature) around each facility was created and then intersected with the population grid to access the proportion of population within each municipality living within that radius. Population exposure to higher than recommended levels of THM was 8.3% but, being cautious, we included THM in our measure. Further, whilst nitrates in public water supplies are almost absent, high nitrate levels are quite common in private water sources in densely populated areas with intensive agriculture. In 2011, 13% of the Portuguese households were not connected to public water supplies, but population often uses both private and public supplies, meaning a much higher proportion of people using private water sources and, consequently, exposed to its contaminants. Again, cautiously, nitrates in private water supplies were included in analysis. Stage 3 – Test associations between selected environmental factors and healthTo validate the previous selection, a preliminary analysis was conducted to confirm whether each of the environmental factors had expected associations with health outcomes, after adjustment for sex, age and socioeconomic deprivation. Environmental factors were included in the development of the PT-MEDIx if significantly associated with mortality. When they were strongly and significantly correlated, the factor with the strongest effect and most scientifically documented was kept in the summary measure. Mortality data were obtained from the Statistics Portugal for a 5-year period (2006-2010) and computed by municipality, gender, age-group (0-14, 15-24, 25-34, 35-44, 45-54, 55-64, 65-74, 75-84, ≥85) and cause of death [all-cause mortality excluding external causes (ICD-9 codes <800, ICD-10 A00-R99), cardiovascular disease (CVD, ICD-9 390-459, ICD-10 I00-I99) and cancer (ICD-9 140-239, ICD-10 C00-D48)]. Sex and age-specific population counts for the same geographic units and periods were also acquired. As no multiple index of socioeconomic deprivation is available for Portugal, we used the proportion of population of each municipality receiving social-financial support in 2011 (last census) as a measure of socioeconomic deprivation ADDIN EN.CITE <EndNote><Cite><Author>Pearce</Author><Year>2010</Year><RecNum>291</RecNum><DisplayText>(17)</DisplayText><record><rec-number>291</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">291</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pearce, Jamie R.</author><author>Richardson, Elizabeth A.</author><author>Mitchell, Richard J.</author><author>Shortt, Niamh K.</author></authors></contributors><titles><title>Environmental justice and health: the implications of the socio-spatial distribution of multiple environmental deprivation for health inequalities in the United Kingdom</title><secondary-title>Transactions of the Institute of British Geographers</secondary-title></titles><periodical><full-title>Transactions of the Institute of British Geographers</full-title></periodical><pages>522-539</pages><volume>35</volume><number>4</number><keywords><keyword>United Kingdom</keyword><keyword>environmental justice</keyword><keyword>health inequalities</keyword><keyword>environmental deprivation</keyword><keyword>GIS</keyword><keyword>binomial regression</keyword></keywords><dates><year>2010</year></dates><publisher>Blackwell Publishing Ltd</publisher><isbn>1475-5661</isbn><urls><related-urls><url>;(17). To account for the large variance in the death counts, negative binomial regression models were used to model the association between each environmental factor and mortality, after adjusting for socioeconomic deprivation, age and sex structure of the population and interaction between socioeconomic and environmental deprivation (PT-MEDIx). The age- and sex-specific population of each municipality was included as exposed population (model offset). Results were expressed as Mortality Rate Ratios (MRRs) and corresponding 95% confidence intervals (95%CI). Sulfur dioxide (SO2) was uncorrelated with all mortality causes (MRR~1), so that it was not included in PT-MEDIx. The variables of temperature were highly correlated; therefore, we only kept mean temperature. The same issue applied to particulate matter (PM10, PM2.5) and ozone (O3). We opted to retain PM10 since reported effects on health are stronger and better studied. Additionally, UVB and water hardness were excluded. The UVB was positively associated with each of the measures of mortality (e.g. MRR=1.130, 95%CI: 1.105-1.155 for all-cause mortality), however, there is no biologic plausibility for an harmful effect of UVB on causes of death other than skin cancer (an infrequent cancer in Portugal ADDIN EN.CITE <EndNote><Cite><Author>Black</Author><Year>1997</Year><RecNum>323</RecNum><DisplayText>(28)</DisplayText><record><rec-number>323</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">323</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Black, R. J.</author><author>Bray, F.</author><author>Ferlay, J.</author><author>Parkin, D. M.</author></authors></contributors><titles><title>Cancer incidence and mortality in the European Union: Cancer registry data and estimates of national incidence for 1990</title><secondary-title>European Journal of Cancer</secondary-title></titles><periodical><full-title>European Journal of Cancer</full-title></periodical><pages>1075-1107</pages><volume>33</volume><number>7</number><keywords><keyword>epidemiology</keyword><keyword>incidence</keyword><keyword>mortality</keyword><keyword>cancer registries</keyword></keywords><dates><year>1997</year><pub-dates><date>6//</date></pub-dates></dates><isbn>0959-8049</isbn><urls><related-urls><url>(96)00492-3</electronic-resource-num></record></Cite></EndNote>(28)), especially because the UVB has little spatial variability in Portugal. Measures of water hardness presented a positive but weak relationship with CVD (MRR=1.006, 95%CI: 1.005-1.007 for magnesium and MRR=1.003, 95%CI: 1.002-1.003 for calcium). Lacking biologic plausibility for a harmful effect of water hardness in CVD, those variables were excluded. Stage 4 – Construct the summary measure and assess its association with healthTo quantify the degree of multiple environmental deprivation in each municipality we developed a single measure combining information on each environmental factor. Ideally, we would have assessed whether each factor exceeded a health-relevant threshold within a municipality. However, the literature shows that there are no robust and consistent thresholds for any of them. We therefore identified municipalities as being exposed to a health-relevant amount of each factor, if situated in the highest quintile of that factor. Municipalities in the highest quintile of exposure received a score of +1 for harmful factors and -1 for beneficial factors. Harmful air pollution was defined as the highest quintile of any of the air pollutants. The PT-MEDIx of each municipality resulted from the sum of these scores and ranged from -1 (least environmental deprivation) to +4 (most). No weighting of the factors was undertaken because there is no robust evidence by which to rank them according to health impact. Once PT-MEDIx was built, negative binomial regression models were again used to estimate the association with mortality, adjusting for age-group, sex, socioeconomic deprivation and interaction between socio-economic deprivation and PT-MEDIx. In order to rule out the possibility that regression analysis might have led to spatially correlated errors, we mapped the residuals and calculated the Moran’s I statistic; only a small and non-significant spatial autocorrelation in the residuals was observed.We conducted several sensitivity analyses to insure that results were not solely determined by the method used, or the time period of the mortality data. These were:Trying multiple ways of computing the index. A uniquely positive index where all variables are considered detrimental, that is, a municipality in the lowest quintile of green space availability punctuated +1. An index based on extreme values of each factor, that is, municipalities in the 95th percentile of exposure received a punctuation of +1 and -1, for harmful and beneficial factors, respectively. Estimating the association between PT-MEDIx and health using mortality data of 2003-2005.Results remained substantively unchanged despite the changes. All models were run in R version 3.0.1 using ‘mgcv’ package ADDIN EN.CITE <EndNote><Cite><Author>Wood</Author><Year>2009</Year><RecNum>328</RecNum><DisplayText>(29)</DisplayText><record><rec-number>328</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">328</key></foreign-keys><ref-type name="Report">27</ref-type><contributors><authors><author> Simon Wood </author></authors></contributors><titles><title>mgcv: Mixed GAM Computation Vehicle with GCV/AIC/REML smoothness estimation</title></titles><dates><year>2009</year></dates><pub-location>Vienna, Austria</pub-location><publisher>R Foundation for Statistical Computing</publisher><urls><related-urls><url>;(29).ResultsSpatial distribution of PT-MEDIxFigure 1 depicts the spatial distribution of PT-MEDIx scores across Portugal. The highest scores were found in the large urban centers, the metropolitan areas of Porto and Lisboa and surroundings, the industrial area of Aveiro (coastline south of Porto) and the southern Alentejo and Algarve regions (Figure 1). In contrast, the depopulated, rural and mountainous inner north and center registered the lowest environmental deprivation. No clear latitudinal/longitudinal trend was observed in PT-MEDIx spatial distribution. One third of the municipalities were classified into the intermediate category, having neither high exposure to harmful nor to beneficial factors. Twelve percent were place in the least environmentally deprived group (depopulated and mountainous areas where 3% of the population lives), whereas only 5% were placed in the category of highest environmental deprivation (with 20% of the population).Table 2 shows median values of the included environmental factors according to PT-MEDIx score – as it rises, an increase in the median exposure to the different factors is observed.PT-MEDIx and healthFor all-cause and cancer mortality, the more environmentally deprived municipalities showed significantly higher MRRs (using intermediate level of environmental deprivation as reference), even after adjustment for confounders (Table 3). Associations with CVD were positive but did not reach statistical significance. Comparing with those in the intermediate category, less environmentally deprived municipalities showed lower mortality rate ratios (MRRs) and more deprived municipalities showed higher MRRs: MRRs for all-cause mortality were 0.962 (95%CI: 0.934-0.991) and 1.209 (95%CI: 1.086-1.344), in the least and most deprived municipalities respectively, and for cancer, 0.957 (95%CI: 0.911-1.006) and 1.345 (95%CI: 1.123-1.598). Putting it in absolute terms, the most environmentally deprived municipalities had 6300 extra deaths per year when compared with the reference category (MEDIx=0). For cancer, the dose-response relationship is particularly evident: the highest MRRs were found in areas with a score of +3 or +4. Discussion The UK/NZ approach to calculating a multiple environmental deprivation index was successfully transferred to Portugal. We identified factors in the physical environment that were related to population’s health in Portugal, which, combined, resulted in an ordinal index which we used to classify municipalities according to the level of multiple environmental deprivation. Significant and plausible associations with all-cause, cardiovascular and cancer mortality were found even after adjusting for demographic and socioeconomic confounders. Associations with cancer were stronger and seemed to follow a dose-response pattern. By creating PT-MEDIx we answered international calls for more evidence-based, ready-to-use and understandable multivariate indexes ADDIN EN.CITE <EndNote><Cite><Author>Corvalán</Author><Year>2000</Year><RecNum>304</RecNum><DisplayText>(30)</DisplayText><record><rec-number>304</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">304</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>C Corvalán </author><author>D Briggs</author><author>G Zielhuis</author></authors></contributors><titles><title>Decision-Making in Environmental Health - from evidence to action</title></titles><dates><year>2000</year></dates><pub-location>London</pub-location><publisher>E & FN Spon</publisher><urls></urls></record></Cite></EndNote>(30). Multivariate indexes are valuable tools for policy makers and other stakeholders. They contribute to a better understanding and monitoring of multidimensional phenomena. When aspects of environment are assessed and regulated as individual components, it is likely that the possibility of improving health via intervention is reduced. We run the risk of fixing one problem, ignorant of the fact that many others exist in the same location. The understanding that there are multiple aspects of environmental deprivation, which might require more than one policy intervention, is therefore vital. Such indexes also help to identify populations which are at relatively greater or lower risk. The major strength of this study lies on the fact that we succeeded to collect a large amount of data and developed a comprehensive environmental deprivation index for Portugal which can now be compared to UK/NZ indexes. Moreover, as with the development of MEDIx in the UK/NZ, we used clear methods, allowing its reproduction in different contexts. The sensitivity analyses help reassure that the results are not unduly driven by the methods selected – the choice of the geographical unit, the temporal reference of mortality data and the way environmental factors were combined, did not meaningfully alter the key results. Moreover, we saw that environmental deprivation represents a crucial health determinant, capable of causing an annual excess of 6000 deaths. Whilst our methodology was deliberately similar to the UK/ NZ indexes, the datasets, variables and final results are distinct (see supplementary table S2). For UK-MEDIx, eight variables (SO2, nitrogen dioxide, PM10, carbon monoxide, average temperature, UVB, green space, industries) were considered, in NZ-MEDIx four (PM10, average temperature, UVB and green space) and in PT-MEDIx, eight. UVB is unrelated with Portuguese mortality, contrasting with a strong protection found in UK and NZ, probably due to the smaller latitudinal extent of Portugal. Temperature had a positive association with mortality in Portugal, whereas in NZ and in UK the association went in the opposite direction. This was not surprising as in Portugal temperature rarely reaches life-threatening lows, but heat extremes are frequent and unquestionably harmful PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb250ZWlybzwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+
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ADDIN EN.CITE.DATA (16, 17). Still, areas with disadvantaged physical environment experienced significantly higher risk of mortality. This study had several limitations. Due to data unavailability, we could not include environmental factors such as noise and radon exposure. Results might change with their inclusion. Although we tried to include accurate and contemporary datasets, the presence of inaccuracies remains a possibility. Establishing a causal relationship between PT-MEDIx and health was also not possible from this cross-sectional study design.There are three particular problems with cross-sectional data and design in this study. 1) PT-MEDIx is a snapshot of the environmental characteristics of each municipality in a single time period, which might not correspond to the environmental characteristics to which the population was exposed during life-time. 2) We assumed place of the residence as the area where health-relevant exposures occur, but individuals might have spent much time in another area. 3) We could not adjust our analysis for other crucial health factors, such as physical activity, smoking or obesity. However, these factors are linked to socioeconomic deprivation and control for deprivation may have reduced their confounding influence. A further weakness is that, as in the UK/NZ analyses, we treated all factors as equal contributors to environmental deprivation. This might be unrealistic, but without robust evidence, any weighting would be arbitrary. Finally, we chose municipalities as geographical units for practical reasons. It is highly likely that these units do not capture very well environmental exposures with high spatial variability, such as green space or pollution. The unavoidable integration of gridded and areal data might also have obscured the true spatial distribution of the environmental exposures. Gridded data had greater resolution than polygons (municipalities); the only exception was UVB, whose grid cell size was larger than the municipality polygons; however, because of the small spatial variability of UVB, matching it with the polygons, doesn’t represent a major problem. In conclusion, this work resulted in an evidence-based and understandable indicator of environmental deprivation for a southern European nation. This measure could help to comprehend the poorly understood spatial inequalities in health in Portugal; to untangle the complex pathway that links individual-characteristics, socioeconomic and physical environment; and to identify vulnerable populations and address their specific problems. PT-MEDIx could be used by both academics and policy-makers. Despite being moderate, associations between environmental deprivation and health cannot be ignored, as they affect a large number of people. After being built for three distinct countries, we encourage other teams to develop similar environmental deprivation indexes and test their validity and utility in explaining health inequalities. Such work will enhance debate about the role of physical environment in health inequalities. Acknowledgments: This work was financed by Portuguese funds through FCT – Funda??o para a Ciência e a Tecnologia in the framework of the project PTDC/SAU-EPI/113424/2009 and SFRH/BD/82529/2011 fellowship. The authors would like to thank the reviewers for their comments that helped to improve the manuscript.Conflicts of interest: None declared.Key-pointsSpatial inequalities in health have been identified but the contribution of physical environment has been largely ignored.We developed an evidence-based and understandable indicator of environmental deprivation for Portugal, including for the first time water quality parameters.Significant and plausible associations between this indicator and all-cause and cancer mortality were found.Hopefully, this measure could assist to better understand spatial inequalities in health; to untangle the complex pathway that links individual-characteristics, socioeconomic and physical environment; and to identify vulnerable populations and address their specific problems. References ADDIN EN.REFLIST 1.van Lenthe FJ, Martikainen P, Mackenbach JP. Neighbourhood inequalities in health and health-related behaviour: Results of selective migration? 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Departamento de Producción da Agência Estatal de Meteorologia de Espanha (?rea de Climatología y Aplicaciones Operativas) & Departamento de Meteorologia e Clima (Divis?o de Observa??o Meteorológica e Clima) d, editor: Departamento de Producción da Agência Estatal de Meteorologia de Espanha (?rea de Climatología y Aplicaciones Operativas) & Departamento de Meteorologia e Clima (Divis?o de Observa??o Meteorológica e Clima), do Instituto de Meteorologia – Portugal; 2011.27.GEOSTAT 1km2 population grid [Internet]. GEOSTAT, Eurostat JRC, European Commission. 2006. Available from: RJ, Bray F, Ferlay J, Parkin DM. Cancer incidence and mortality in the European Union: Cancer registry data and estimates of national incidence for 1990. European Journal of Cancer. 1997;33(7):1075-107.29.Wood S. mgcv: Mixed GAM Computation Vehicle with GCV/AIC/REML smoothness estimation. Vienna, Austria: R Foundation for Statistical Computing, 2009.30.Corvalán C, Briggs D, Zielhuis G. Decision-Making in Environmental Health - from evidence to action. London: E & FN Spon; 2000.31.Monteiro A, Carvalho V, Oliveira T, Sousa C. Excess mortality and morbidity during the July 2006 heat wave in Porto, Portugal. International journal of biometeorology. 2013;57(1):155-67.32.Nogueira PJ, Falcao JM, Contreiras MT, Paixao E, Brandao J, Batista I. Mortality in Portugal associated with the heat wave of August 2003: early estimation of effect, using a rapid method. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2005;10(7):150-3.33.Hoek G, Krishnan RM, Beelen R, Peters A, Ostro B, Brunekreef B, et al. Long-term air pollution exposure and cardio- respiratory mortality: a review. Environmental health : a global access science source. 2013;12(1):43.34.Caetano M, Nunes V, Nunes A. CORINE Land Cover 2006 for Continental Portugal, Relatório técnico. Instituto Geográfico Português, 2009.35.Caetano M, Araújo A, Neves A, Pereira M. Accuracy assessment of the CORINE Land Cover 2006 map of Continental Portugal, Relatório técnico. Instituto Geográfico Português, 2009.TablesTable 1 – Description of the datasets and municipality-level measures derived for the selected environmental factorsEnvironmental factorSourceDescriptionProcessingMunicipality-level measureYear(s)Air PollutionAirbase from European Environment Agency (EEA) ADDIN EN.CITE <EndNote><Cite><Author>Hoek</Author><Year>2013</Year><RecNum>81</RecNum><DisplayText>(33)</DisplayText><record><rec-number>81</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">81</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hoek, G.</author><author>Krishnan, R. M.</author><author>Beelen, R.</author><author>Peters, A.</author><author>Ostro, B.</author><author>Brunekreef, B.</author><author>Kaufman, J. D.</author></authors></contributors><titles><title>Long-term air pollution exposure and cardio- respiratory mortality: a review</title><secondary-title>Environ Health</secondary-title><alt-title>Environmental health : a global access science source</alt-title></titles><periodical><full-title>Environ Health</full-title><abbr-1>Environmental health : a global access science source</abbr-1></periodical><alt-periodical><full-title>Environ Health</full-title><abbr-1>Environmental health : a global access science source</abbr-1></alt-periodical><pages>43</pages><volume>12</volume><number>1</number><edition>2013/05/30</edition><dates><year>2013</year><pub-dates><date>May 28</date></pub-dates></dates><isbn>1476-069X (Electronic)
1476-069X (Linking)</isbn><accession-num>23714370</accession-num><urls></urls><custom2>PMC3679821</custom2><electronic-resource-num>10.1186/1476-069x-12-43</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>Eng</language></record></Cite></EndNote>(33)Annual averages of:particulate Matter (PM10 and PM2.5), ozone (O3), nitrogen dioxide (NO2), sulphur dioxide (SO2) and carbon monoxide (CO)EEA provide 10km grids for PM10, PM2.5 and O3, exclusively.10km grids for the remaining pollutants were derived from station data (also from EEA) and interpolated using kriging.Population-weighted mean of each pollutant2006Green spaceCoordination of Information on the Environment (CORINE) Land Cover Data ADDIN EN.CITE <EndNote><Cite><Author>Caetano</Author><Year>2009</Year><RecNum>278</RecNum><DisplayText>(34, 35)</DisplayText><record><rec-number>278</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">278</key></foreign-keys><ref-type name="Report">27</ref-type><contributors><authors><author>M Caetano</author><author>V Nunes</author><author>A Nunes</author></authors></contributors><titles><title> CORINE Land Cover 2006 for Continental Portugal, Relatório técnico</title></titles><dates><year>2009</year></dates><publisher>Instituto Geográfico Português</publisher><urls></urls></record></Cite><Cite><Author>Caetano</Author><Year>2009</Year><RecNum>279</RecNum><record><rec-number>279</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">279</key></foreign-keys><ref-type name="Report">27</ref-type><contributors><authors><author>M Caetano</author><author>A Araújo</author><author>A Neves</author><author>M Pereira</author></authors></contributors><titles><title>Accuracy assessment of the CORINE Land Cover 2006 map of Continental Portugal, Relatório técnico</title></titles><dates><year>2009</year></dates><publisher>Instituto Geográfico Português</publisher><urls></urls></record></Cite></EndNote>(34, 35)Map of Land Cover (44 classes)27 classes corresponding to green areas were selected.Total % of green space2006ClimatePortuguese Institute for Ocean and Atmosphere (Instituto Português do Mar e da Atmosfera, IPMA)andSpanish Meteorology Agency (Agencia Estatal de Meteorología, AEMET)Climatological averages by station (n=74):Annual mean (year),Warmest month (July) maximum andColdest month (January) minimum temperatures (?C)1 km grids for each temperature were derived using kriging as interpolation methodPopulation-weighted mean of each climate variable1970-2000UVB IndexPortuguese Institute for Ocean and Atmosphere (IPMA, Instituto Português do Mar e da Atmosfera)Average UVB index (unitless)GIS grid with a spatial resolution of 0.5? (~50 km) obtained by satellite images (clean sky)-Population-weighted mean2003-2012Industrial facilitiesEuropean Pollutant Emission Register (EPER)Location of the waste management sites, mineral and chemical manufacture, metal production and processing facilities and combustion installations.-Proportion of population living within 3 km of some facility2008Drinking water qualityPublic water suppliesRegulator Institute of Water and Waste (Instituto Regulador de ?guas e Resíduos, IRAR)Annual median by municipalityFor each parameter:Magnesium (Mg), Calcium (Ca), Nitrates (NO3-), Aluminum (Al), Arsenic (As), Manganese (Mn), Lead (Pb) and THM-Median of each parameter2011Private water supplies (ground water from wells, boreholes and springs)Water Resources Information National System (Sistema Nacional de Informa??o de Recursos Hídricos, SNIRH).Median by station for nitrates(NO3-)1 km grids were derived using kriging as interpolation method1997-2012Table 2 - Characteristics of the MEDIx scores - median values of the environmental factors for each PT-MEDIx score.PT-MEDIx score-1 (least environmental deprivation)0+1+2+3+4 (most environmental deprivation)No. of municipalities (%)34 (12.2)93 (33.5)60 (21.6)45(16.2)33(11.9)13(4.7)Population (2006) (%)337,085 (3.4)1,645,962 (16.4)2,067,310 (20.6)1,723,042 (17.2)2,234,933 (22.3)2,017,506 (20.1)Environmental factorsPM10a12.9715.7817.7818.8521.6722.91NO2a18.6420.0322.0123.0826.9729.19COa168.13165.65192.04191.70232.89246.34Mean temperature (?C)b13.0715.0515.3315.73 15.77 16.01 Industry proximity (%)c0.000.733.997.7962.5165.54Green space (%)d99.2598.0696.3495.0178.2673.08THMe5.005.009.2819.2032.3043.00NO3- f7.008.0011.0024.0027.0029.00Deprivationg2.953.734.074.464.634.52a annual average (?g/m3); b annual average temperature (1970-2000); c proportion of municipality’s population living within 3km of an industrial facility; d proportion of the municipality’s area covered with green space; e trihalometanes annual median (?g/m3); f annual median (mg/m3); g Proportion of population of each municipality receiving social-financial support in 2011.Table 3 – Mortality Rate Ratios (and corresponding 95% confidence intervals) for the association between PT-MEDIx and mortality, adjusted for covariates (age, sex, socioeconomic deprivationa and interaction between socioeconomic deprivation and PT-MEDIx). All-causeCardiovascular diseaseCancerPT-MEDIx-1 (least deprived)0.962 (0.934-0.991)**0.924 (0.880-0.969)**0.957 (0.911-1.006)01.0001.0001.000+11.024 (0.979-1.072)1.115 (1.038-1.198)**1.005 (0.930-1.084)+21.012 (0.970-1.056)1.032 (0.962-1.106)1.147 (1.078-1.220)***+31.199 (1.083-1.327)***1.106 (0.929-1.312)1.312 (1.100-1.552)**4 (most deprived)1.209 (1.086-1.344)***1.071 (0.892-1.281)1.345 (1.123-1.598)***-2 × log-likelihood108130.370747.072202.9Likelihood ratio test (p-value)c<0.001<0.001<0.001* 0.01 <p-value<0.05; **0.001<p-value<0.01; ***p<0.001 aProportion of population of each municipality receiving social-financial support in 2011cChi-square test to compare the final model (with PT-MEDIx) and the incomplete model (without PT-MEDIx)Figure Figure 1 – Spatial distribution of PT-MEDIx scores across Portugal.S1. 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ADDIN EN.CITE.DATA (21, 22).Skin cancer (harmful):Meta-analysis RR PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYW5kaW5pPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48
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ADDIN EN.CITE.DATA (19): intermittent sun exposure (1.61, 1.31- 1.99); sunburn history (2.03, 1.73-2.37); total sun exposure (1.34, 1.02-1.77)Cancer mortality (protective):OR (highest vs. lowest sunlight exposure) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GcmVlZG1hbjwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+
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ADDIN EN.CITE.DATA (28-31). Residing near food or paper industries seems to have null/limited health effects.Risk in the proximity of:Incinerator – 3.5% excess risk of cancer ADDIN EN.CITE <EndNote><Cite><Author>Porta</Author><Year>2009</Year><RecNum>141</RecNum><DisplayText>(30)</DisplayText><record><rec-number>141</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">141</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Porta, D.</author><author>Milani, S.</author><author>Lazzarino, A. I.</author><author>Perucci, C. A.</author><author>Forastiere, F.</author></authors></contributors><auth-address>Department of Epidemiology, Regional Health Service Lazio Region, Rome, Italy. porta@asplazio.it</auth-address><titles><title>Systematic review of epidemiological studies on health effects associated with management of solid waste</title><secondary-title>Environ Health</secondary-title><alt-title>Environmental health : a global access science source</alt-title></titles><periodical><full-title>Environ Health</full-title><abbr-1>Environmental health : a global access science source</abbr-1></periodical><alt-periodical><full-title>Environ Health</full-title><abbr-1>Environmental health : a global access science source</abbr-1></alt-periodical><pages>60</pages><volume>8</volume><edition>2009/12/25</edition><keywords><keyword>Air Pollutants/ adverse effects</keyword><keyword>Cluster Analysis</keyword><keyword>Humans</keyword><keyword>Incineration</keyword><keyword>Neoplasms/ etiology</keyword><keyword>Occupational Exposure/adverse effects</keyword><keyword>Refuse Disposal</keyword><keyword>Residence Characteristics</keyword><keyword>Risk Assessment</keyword><keyword>Risk Factors</keyword><keyword>Water Pollutants, Chemical/ adverse effects</keyword></keywords><dates><year>2009</year></dates><isbn>1476-069X (Electronic)
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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYXJkPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVj
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ADDIN EN.CITE.DATA (38). THM:Bladder cancer (meta-analysis) – OR=1.47 (1.05-2.05) for exposure >50?g/l vs. ≤5?g/l PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WaWxsYW51ZXZhPC9BdXRob3I+PFllYXI+MjAwNzwvWWVh
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ADDIN EN.CITE.DATA (33) Colon cancer (meta-analysis) – OR=1.27 (1.08-1.50) ADDIN EN.CITE <EndNote><Cite><Author>Rahman</Author><Year>2010</Year><RecNum>169</RecNum><DisplayText>(32)</DisplayText><record><rec-number>169</rec-number><foreign-keys><key app="EN" db-id="ate9a0dt7ztx2xe9er8xw05uderwaddxxdd9">169</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Rahman, M. B.</author><author>Driscoll, T.</author><author>Cowie, C.</author><author>Armstrong, B. K.</author></authors></contributors><auth-address>School of Public Health, The University of Sydney, Sydney, NSW, Australia. bayzid@unsw.edu.au</auth-address><titles><title>Disinfection by-products in drinking water and colorectal cancer: a meta-analysis</title><secondary-title>Int J Epidemiol</secondary-title><alt-title>International journal of epidemiology</alt-title></titles><periodical><full-title>Int J Epidemiol</full-title><abbr-1>International journal of epidemiology</abbr-1></periodical><alt-periodical><full-title>Int J Epidemiol</full-title><abbr-1>International journal of epidemiology</abbr-1></alt-periodical><pages>733-45</pages><volume>39</volume><number>3</number><edition>2010/02/09</edition><keywords><keyword>Case-Control Studies</keyword><keyword>Cohort Studies</keyword><keyword>Colonic Neoplasms/ epidemiology</keyword><keyword>Disinfectants/ adverse effects</keyword><keyword>Drinking</keyword><keyword>Humans</keyword><keyword>Odds Ratio</keyword><keyword>Rectal Neoplasms/ epidemiology</keyword><keyword>Water/ chemistry</keyword><keyword>Water Pollutants, Chemical/ adverse effects</keyword></keywords><dates><year>2010</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1464-3685 (Electronic)
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ADDIN EN.CITE.DATA (38).NoiseNoise has been consistently associated with cardiovascular morbidity and emotional stress PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gS2VtcGVuPC9BdXRob3I+PFllYXI+MjAwMjwvWWVh
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Supplementary table – Overview table comparing Portuguese (PT-MEDIx), United Kingdom (UK-MEDIx) and New Zealand (NZ-MEDIx) environmental deprivation indexesPT-MEDIxUK-MEDIxNZ-MEDIxNo. of geographic units27810,6541860Average population per geographic unit 36,00055182300No. of included variables884No. of beneficial variables122No. of detrimental variables762Index range-1 to +4-2 to +3-2 to +2Proportion of the population living in the least environmentally deprived areas3.4%1.6%18.2%Proportion of the population living in the most environmentally deprived areas20.1%0.4%21.1%Control for socioeconomic deprivationYESYESYESControl for health-related behaviors NONOYES ................
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