For those with darker skin the rash of dermatomyositis may ...
Women of color
are disproportionally affected by
myositis diseases
Myositis is an inflammatory disease of the muscles that can cause severe disability. Symptoms include falling, trouble climbing stairs, difficulty raising arms over the head, and unusual rashes. In adults, certain forms of myositis affect women of color more than Caucasians.
African Americans
with ILD are younger at diagnosis. 6
INCIDENCE
For those with darker skin the rash of dermatomyositis may not be as easy to identify as it is on lighter skin.
DIAGNOSIS
African American myositis patients have higher frequencies of certain markers of more severe disease (antisynthetase syndrome and necrotizing myopathy)
INCIDENCE than European-American myositis patients. 4
Creatine kinase levels (a measure of disease severity)
were found to be significantly higher in African
SEVERITY Americans compared to Caucasians. 3
In adults, DM, PM, and NM affect more African Americans than
INCIDENCE Caucasians. 1, 2
African American myositis patients with a complication
called antisynthetase syndrome have more severe lung
dCiseaOse. 5MPLICATIONS
DISEASE ABBREVIATIONS & KEY TERMS
DM - dermatomyositis ILD - interstitial lung disease JDM - juvenile dermatomyositis
NM - necrotizing myopathy PM - polymyositis
Nonwhite women are twice as likely to die than others
with myositis, and they are four times more likely to die
MORTALITY than white men with the disease. 7
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3940 Laurel Canyon Blvd, Suite 1506 Studio City, CA 91604
@TheMyositisAssc
Nonwhite DM patients hFsakovirentgthhroeesaetreawrshiltehonfgdtdaherskr-er of stay and higher costsmofactaormeywohseitnisthmeayy not are hospitalized. 8 be as easy to identify
COST OF CARE as it is on lighter skin.
Mortality rates from DM and PM are highest among women of color. 7
MORTALITY
In the childbearing years (ages 15-34), mortality in nonwhite women with myositis is 3.5 times greater than in Caucasian women with the disease. 7
MORTALITY
African American children with JDM have an increased risk of developing calcinosis, a painful accumulation of
COMPLICATIONS calcium under the skin. 9
Nonwhite women with multiple chronic conditions have the highest rates of hospitalization for dermatomyositis. 8
HOSPITALIZATION
Nonwhite women die at a younger age than others with DM and PM. 7
MORTALITY
While these statistics show the disproportionate burden of myositis on women of color, you are not alone! TMA is here for you with support and resources.
Sources
1. Gaubitz, M. (2006). Epidemiology of connective tissue disorders. Rheumatology, 45(Suppl 3); iii3?iii4. doi:10.1093/rheumatology/kel282. 2. Smoyer-Tomic, K.E., et al. 2012. Incidence and prevalence of idiopathic inflammatory myopathies among commercially insured, Medicare supplemental insured, and Medicaid enrolled populations:
an administrative claims analysis. BMC Musculoskeletal Disorders, 13(103). doi:10.1186/1471-2474-13-103. 3. Schiopu et al. 2012. Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: Effect of corticosteroids, methotrexate, and azathioprine. Arthritis Research &
Therapy,14(R22). doi:10.1186/ar3704. 4. Johnson C., et al. 2014. Clinical and pathologic differences in interstitial lung disease based on antisynthetase antibody type. Respiratory Medicine, 108(10); 1542-1548. doi:10.1016/
j.rmed.2014.09.003. 5. Pinal-Fernandez, Iago, et al. (2017). "A Longitudinal Cohort Study of the Anti-Synthetase Syndrome: Increased Severity of Interstitial Lung Disease in Black Patients and Patients with Anti-PL7 and
Anti-PL12 Autoantibodies." Rheumatology, 56(6); 999?1007. doi:10.1093/rheumatology/kex021. 6. Adegunsoye, Ayodeji, et al. (2018). African-American race and mortality in interstitial lung disease: A multicentre propensity-matched analysis. European Respiratory Journal,
51(6). doi:10.1183/13993003.00255-2018. 7. Hochberg, Marc C., et al. 1983. Mortality from polymyositis and dermatomyositis in the United States, 1968?1978. Arthritis & Rheumatism, 26(12); 1465-1471. doi:10.1002/art.1780261208. 8. Kwa, Michael C., et al. 2017. Predictors of hospitalization, length of stay, and cost of care among adults with dermatomyositis in the United States. Arthritis Care & Research,
69(9);1391-1399. doi:10.1002/acr.23190. 9. Hoeltzel, Mark F, et al. 2012. Race is a risk factor for calcinosis in patients with JDM: Early results from the CARRAnet registry study. Pediatric Rheumatology, 10(Suppl 1). doi:10.1186/1546-0096-10-s1-a65.
Sponsored by Mallinckrodt Pharmaceuticals
Conditions apply. More text with restrictions. ? 147 Business Street ? Zip City
Join the effort to find a cure | wTwhewM.byaorskiativseAnsuseofcoiautniodnati|onw.owrwg.m| yPo.s3it2is3.o.r9g69.8082@myositis
3940 Laurel Canyon Blvd, Suite 1506 Studio City, CA 91604
@TheMyositisAssc
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