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Table S1 List of yeasts isolates from different clinical samples with their GenBank accession no., strain no., source of isolates and details of closest similarity included in the phylogenetic analysis.S. No.Strain IdIdentifiedAcc. No.Source of IsolateClosest SimilarityPercent Similarity11_10Candida albicansMK026215UrineCandida albicans CBS 87819921_11Candida tropicalisMK026227UrineCandida tropicalis ATCC 75010031_13Candida glabrataMK026347UrineCandida glabrata CBS 1389941_14Candida parapsilosisMK026228UrineCandida parapsilosis CBS 1105910051_17Clavispora lusitaniaeMK026240UrineClavispora lusitaniae CBS 50309961_18Candida parapsilosisMK026244UrineCandida parapsilosis CBS 1105910071_19Clavispora lusitaniaeMK026212SputumClavispora lusitaniae CBS 503010081_22Candida tropicalisMK026246UrineCandida tropicalis ATCC 75010091_27Cyberlindnera fabianiiMK026280BloodCyberlindnera fabianii NRRL 1871100101_30Candida albicansMK026362UrineCandida albicans CBS 878199111_34Clavispora lusitaniaeMK026218SputumClavispora lusitaniae CBS 44131001210_1Candida parapsilosisMK026210SputumCandida parapsilosis CBS 71561001310_10Candida glabrataMK026342SputumCandida glabrata CBS 138991410_11Candida albicansMK026363UrineCandida albicans CBS 8781991510_12Candida albicansMK026364BALCandida albicans CBS 8781991610_13Candida albicansMK026221UTICandida albicans CBS 8781991710_14Trichosporon asahiiMK026306BloodTrichosporon asahii CBS 24791001810_15Candida glabrataMK026365BloodCandida glabrata CBS 138991910_16Candida tropicalisMK026283HVSCandida tropicalis ATCC 7501002010_17Candida albicansMK026366HVSCandida albicans CBS 8781992110_18Candida tropicalisMK026260HVSCandida tropicalis ATCC 7501002210_19Candida tropicalisMK026356HVSCandida tropicalis NN 4992310_2Candida glabrataMK026313UrineCandida glabrata CBS 138992410_22Candida glabrataMK026336HVSCandida glabrata CBS 138992510_23Candida tropicalisMK026275HVSCandida tropicalis ATCC 7501002610_25Candida tropicalisMK026276HVSCandida tropicalis ATCC 7501002710_26Candida tropicalisMK026350HVSCandida tropicalis NN 4982810_28Candida albicansMK026367HVSCandida albicans CBS 8781992910_3Candida glabrataMK026224Pericardial FluidCandida glabrata CBS 138993010_30Candida glabrataMK026225HVSCandida glabrata CBS 138993110_31Candida albicansMK026368HVSCandida albicans CBS 8781993210_4Candida albicansMK026369PUSCandida albicans CBS 8781993310_5Candida tropicalisMK026314UrineCandida tropicalis ATCC 7501003410_6Candida tropicalisMK026220SputumCandida tropicalis ATCC 750993510_7Candida glabrataMK026344HVSCandida glabrata CBS 138993610_8Candida albicansMK026370PUSCandida albicans CBS 8781993710_9Candida albicansMK026371CorneaCandida albicans CBS 8781993811_1Candida albicansMK026372UrineCandida albicans CBS 8781993911_16Candida tropicalisMK026353UrineCandida tropicalis NN 4994011_17Candida tropicalisMK026355PUSCandida tropicalis NN 4994111_18Candida tropicalisMK026270UrineCandida tropicalis ATCC 7501004211_19Candida albicansMK026310SputumCandida albicans CBS 1912994311_2Candida parapsilosisMK026298BloodCandida parapsilosis CBS 7156994411_3Candida glabrataMK026245UrineCandida glabrata CBS 138994511_6Candida tropicalisMK026287UrineCandida tropicalis ATCC 7501004611_7Candida albicansMK026293UrineCandida albicans CBS 8781994711_8Candida parapsilosisMK026241BloodCandida parapsilosis CBS 110591004811_9Candida tropicalisMK026257BloodCandida tropicalis ATCC 7501004912_1Candida glabrataMK026315UrineCandida glabrata CBS 138995012_3Candida parapsilosisMK026351SputumCandida parapsilosis CBS 71561005112_4Candida tropicalisMK026358UrineCandida tropicalis NN 4995212_6Candida albicansMK026294SputumCandida albicans CBS 1912995312_7Candida tropicalisMK026271SputumCandida tropicalis ATCC 7501005412_8Candida tropicalisMK026256UrineCandida tropicalis ATCC 7501005513_11Candida glabrataMK026332UrineCandida glabrata CBS 138995613_14Candida albicansMK026288Transbronchial BiopsyCandida albicans CBS 1912995713_15Candida albicansMK026239Transbronchial BiopsyCandida albicans CBS 8781995813_17Candida albicansMK026316EQUASCandida albicans CBS 1912995913_18Candida albicansMK026373BALCandida albicans CBS 8781996013_19Candida tropicalisMK026317SputumCandida tropicalis ATCC 7501006113_2Candida parapsilosisMK026261UrineCandida parapsilosis CBS 110591006213_22Candida albicansMK026324UrineCandida albicans CBS 1912996313_23Candida tropicalisMK026284SputumCandida tropicalis ATCC 7501006413_24Candida tropicalisMK026359UrineCandida tropicalis ATCC 7501006513_26Candida parapsilosisMK026265UrineCandida parapsilosis CBS 110591006613_27Candida tropicalisMK026277UrineCandida tropicalis ATCC 7501006713_28Candida albicansMK026374SputumCandida albicans CBS 8781996813_29Candida tropicalisMK026299BloodCandida tropicalis ATCC 7501006913_30Candida parapsilosisMK026285HVSCandida parapsilosis CBS 71561007013_32Candida albicansMK026330SputumCandida albicans CBS 1912997113_34Candida tropicalisMK026318UrineCandida tropicalis ATCC 7501007213_36Lodderomyces sp.MK026348SputumLodderomyces elongisporus NRRL YB-4239977313_37Candida parapsilosisMK026272BloodCandida parapsilosis CBS 110591007413_39Candida albicansMK026375UrineCandida albicans CBS 8781997513_4Candida tropicalisMK026266UrineCandida tropicalis ATCC 7501007613_8Candida tropicalisMK026278UrineCandida tropicalis ATCC 750100772_11Candida parapsilosisMK026249UrineCandida parapsilosis CBS 11059100782_13Candida albicansMK026308UrineCandida albicans CBS 1912100792_14Candida albicansMK026376UrineCandida albicans CBS 878199802_16Candida tropicalisMK026377UrineCandida tropicalis ATCC 75099812_19Candida glabrataMK026281UrineCandida glabrata CBS 138100822_20Candida tropicalisMK026235UrineCandida tropicalis ATCC 750100832_21Candida albicansMK026378UrineCandida albicans CBS 878199842_23Candida albicansMK026379UrineCandida albicans CBS 878199852_24Candida tropicalisMK026258UrineCandida tropicalis ATCC 750100862_25Candida tropicalisMK026273SputumCandida tropicalis ATCC 750100872_27Candida albicansMK026325SputumCandida albicans CBS 1912100882_31Candida glabrataMK026337UrineCandida glabrata CBS 138100892_4Candida tropicalisMK026223UrineCandida tropicalis ATCC 750100902_5Candida tropicalisMK026253UrineCandida tropicalis ATCC 750100913_10Candida albicansMK026380UrineCandida albicans CBS 878199923_11Candida albicansMK026326UrineCandida albicans CBS 1912100933_12Candida albicansMK026320UrineCandida albicans CBS 1912100943_13Candida albicansMK026381UrineCandida albicans CBS 878199953_16Candida glabrataMK026321BloodCandida glabrata CBS 138100963_17Candida albicansMK026327SputumCandida albicans CBS 1912100973_19Candida albicansMK026382SputumCandida albicans CBS 878199983_2Candida albicansMK026383UrineCandida albicans CBS 878199993_20Candida albicansMK026384SputumCandida albicans CBS 8781991003_21Candida albicansMK026217HVSCandida albicans CBS 8781991013_22Candida albicansMK026385UrineCandida albicans CBS 8781991023_24Candida albicansMK026331UrineCandida albicans CBS 19121001033_25Clavispora lusitaniaeMK026203SputumClavispora lusitaniae CBS 44131001043_26Candida glabrataMK026300CSFCandida glabrata CBS1381001053_3Candida albicansMK026386SputumCandida albicans CBS 8781991063_4Candida albicansMK026213UrineCandida albicans CBS 8781991073_5Candida albicansMK026387HVSCandida albicans CBS 8781991083_6Kluyveromyces marxianusMK026360UrineKluyveromyces marxianus CBS 712991093_7Kluyveromyces marxianusMK026209UrineKluyveromyces lactis CBS 6831001103_8Candida albicansMK026301HVSCandida albicans CBS 19121001114_12Candida albicansMK026388UrineCandida albicans CBS 8781991124_13Candida albicansMK026263ETTCandida albicans CBS 8781991134_17Candida albicansMK026352SputumCandida albicans CBS 1912991144_2Candida africanaMK026279UrineCandida africana991154_21Candida albicansMK026390SputumCandida albicans CBS 8781991164_22Candida tropicalisMK026302ETTCandida tropicalis ATCC 7501001174_24Candida glabrataMK026307UrineCandida glabrata CBS 138991184_8Kluyveromyces marxianusMK026333SputumKluyveromyces lactis CBS 683991195_1Candida tropicalisMK026231UrineCandida tropicalis ATCC 750991205_10Candida glabrataMK026345SputumCandida glabrata CBS 138991215_13Candida tropicalisMK026274UrineCandida tropicalis ATCC 7501001225_16Candida glabrataMK026311SputumCandida glabrata CBS 138991235_17Candida tropicalisMK026230UrineCandida tropicalis ATCC 7501001245_18Kodamaea ohmeriMK026219BloodKodamaea ohmeri1001255_2Candida tropicalisMK026322RT (Blood)Candida tropicalis ATCC 7501001265_20Candida albicansMK026226UrineCandida albicans CBS 19121001275_6I. orientalis (=C. krusei= Pichia kudriavzevii)MK026349UrineI. orientalis (=C. krusei=Pichia kudriavzevii) CBS 51471001286_1Candida tropicalisMK026282UrineCandida tropicalis ATCC 7501001296_11Candida tropicalisMK026346UrineCandida tropicalis ATCC 7501001306_12Candida albicansMK026391HVSCandida albicans CBS 8781991316_13Candida glabrataMK026233HVSCandida glabrata CBS 138991326_14Candida albicansMK026254HVSCandida albicans CBS 8781991336_16Candida albicansMK026392HVSCandida albicans CBS 8781991346_18Candida albicansMK026323HVSCandida albicans CBS 19121001356_2Candida albicansMK026295UrineCandida albicans CBS 19121001366_3Candida glabrataMK026343UrineCandida glabrata CBS 138991376_5Candida albicansMK026393ETTCandida albicans CBS 8781991387_1Candida albicansMK026394SputumCandida albicans CBS 8781991397_10Candida albicansMK026395HVSCandida albicans CBS 8781991407_3Candida glabrataMK026304BloodCandida glabrata CBS 138991417_4Candida albicansMK026286UrineCandida albicans CBS 1912991427_5Candida tropicalisMK026396SputumCandida tropicalis ATCC 750991437_6Candida albicansMK026357HVSCandida albicans CBS 1912991447_9Candida tropicalisMK026207HVSCandida tropicalis ATCC 7501001458_1Candida albicansMK026206PUSCandida albicans CBS 8781991468_10Candida tropicalisMK026309ETTCandida tropicalis ATCC 7501001478_12Candida albicansMK026204SputumCandida albicans CBS 8781991488_14Candida albicansMK026290UrineCandida albicans CBS 19121001498_15Candida parapsilosisMK026341BloodCandida parapsilosis CBS 7156991508_16Candida tropicalisMK026255UrineCandida tropicalis ATCC 7501001518_17Candida albicansMK026251UrineCandida albicans CBS 1912991528_18Candida albicansMK026205SputumCandida albicans CBS 8781991538_20Candida parapsilosisMK026259Peritoneal FluidCandida parapsilosis CBS 110591001548_23Candida parapsilosisMK026296UrineCandida parapsilosis CBS 71561001558_3Candida albicansMK026334HVSCandida albicans CBS 19121001568_4Candida albicansMK026305UrineCandida albicans CBS 19121001578_7Candida albicansMK026397UrineCandida albicans CBS 8781991588_8Candida tropicalisMK026268PUSCandida tropicalis ATCC 750991598_9Candida tropicalisMK026335SputumCandida tropicalis ATCC 7501001609_10Candida tropicalisMK026252UrineCandida tropicalis ATCC 7501001619_12Candida glabrataMK026237Peritoneal FluidCandida glabrata CBS 138991629_13Candida glabrataMK026236EQUASCandida glabrata CBS 138991639_2Candida albicansMK026291ETTCandida albicans CBS 19121001649_3Candida tropicalisMK026243StoolCandida tropicalis ATCC 7501001659_4Candida albicansMK026398BloodCandida albicans CBS 8781991669_5I. orientalis (=C. krusei= Pichia kudriavzevii)MK026312ETTI. orientalis (=C. krusei=Pichia kudriavzevii) CBS 5147991679_6Candida albicansMK026216Right Chick MucosaCandida albicans CBS 8781991689_8Candida tropicalisMK026211BloodCandida tropicalis ATCC 7501001699_9Candida glabrataMK026292UrineCandida glabrata CBS 138991701_12Cyberlindnera fabianii-Blood?Cyberlindnera fabianii CBS 564099?1718_13Candida albicans-Sputum?Candida albicans ATCC 188041001721_28Candida albicans-Urine?Candida albicans ATCC 1880499?1732_8Candida tropicalis-Urine?Candida tropicalis ATCC 750?1001744_5Candida albicans-Sputum?Candida albicans ATCC 18804991755_19Candida albicans-Urine?Candida albicans ATCC 18804991765_7Candida albicans-Urine?Candida albicans ATCC 18804?99 Table S2 List of yeasts isolates from different clinical samples and their response to antifungal agents viz., Clotrimazole (CC10), Fluconazole (FLC25), Itraconazole (IT10), Ketoconazole (KT10), Nystatin (NS100).S. No.Sample IDIdentityAntifungal AgentCC10FLC25IT10KT10NS1001_10Candida albicansSIRSS1_11Candida tropicalisRRRRS1_13Candida glabrataSSISS1_14Candida parapsilosisSRISS1_18Candida parapsilosisSSSSS1_19Clavispora lusitaniaeRRRIS1_22Candida tropicalisRRRRS1_27Cyberlindnera fabianiiRSRSS1_28Candida albicansSSSSS1_30Candida albicansSSRSS1_34Clavispora lusitaniaeSSISS2_5Candida tropicalisRRRRS2_11Candida parapsilosisSRRSS2_13Candida albicansSSRSS2_14Candida albicansSSISS2_19Candida glabrataRRR-I2_20Candida tropicalisRRRRI2_21Candida albicansRRRRI2_23Candida albicansSSISS2_24Candida tropicalisRRRRS2_25Candida tropicalisRRRRS2_27Candida albicansSSISS3_3Candida albicansSISIS3_4Candida albicansIRRSS3_6Kluyveromyces marxianusSSRSI3_7Kluyveromyces marxianusRRRRS3_8Candida albicansSSRSS3_10Candida albicansSSSSS3_11Candida albicansSSISS3_13Candida albicansSSSSS3_16Candida glabrataRRRRI3_17Candida albicansSSISS3_19Candida albicansSRRRI3_20Candida albicansRRRSI3_21Candida albicansSSISS3_22Candida albicansSRRSS3_24Candida albicansSSISS3_25Clavispora lusitaniaeRRRIS3_26Candida glabrataRRRRS4_5Candida albicansSSISS4_12Candida albicansSRRSS4_21Candida albicansSSSSS5_1Candida tropicalisRRRRS5_2Candida tropicalisRRRRS5_6Pichia kudriavzeviiIRRRI5_7Candida albicansRRRRS5_10 Candida glabrataIRRRS5_13Candida tropicalisRRRRI5_16 Candida glabrataRRRRI5_17Candida tropicalisRRRRS5_18Kodamaea ohmeriSRRSS5_19Candida albicansRRRSS5_20Candida albicansIIRSS6_2Candida albicansSRRSS6_3Candida glabrataRRRRS 6_5Candida albicansSSISS 6_11Candida tropicalisRRRRS 6_12Candida albicansRRRRI 6_13Candida glabrataRRRRI6_14Candida albicansRRIIS6_16Candida albicansRRISS 6_18Candida albicansIRRSI7_1Candida albicansSSISS7_3Candida glabrataRRRRS7_4Candida albicansSSRSI7_5Candida tropicalisRRRIS7_6Candida albicansRRRRI7_9Candida tropicalisRRRSS7_10Candida albicansRIRSS8_1Candida albicansIIRSS8_2Candida auris RRRIR8_3Candida albicansISRSS8_4Candida albicansRRRRS8_7Candida albicansRRRRS8_8Candida tropicalisRRRRS8_9Candida tropicalisRRRRS8_10Candida tropicalisSSRSS8_12Candida albicansRRRRS8_13Candida albicansRSIRS8_14Candida albicansSSISS8_15Candida parapsilosisSIISS8_17Candida albicansISRSS8_18Candida albicansISRSS8_20Candida parapsilosisSSRSI8_21Candida albicansSRISS8_23Candida parapsilosisSSISI9_2Candida albicansSSISS9_5Pichia kudriavzeviiRRRRR9_6Candida albicansSSSSS9_8Candida tropicalisIRRRS9_9Candida glabrataRRRRI9_10Candida tropicalisRRRRS9_13Candida glabrataRRRRS10_1Candida parapsilosisSRRSS10_2Candida glabrataRRRRI10_3Candida glabrataRRRRS10_4Candida albicansRIRII10_5Candida tropicalisRRRRI10_6Candida tropicalisRRRRI10_7Candida glabrataRRRRS10_8Candida albicansIRRSS10_9Candida albicansRRRII10_10Candida glabrataRRRRR10_11Candida albicansRRRII10_12Candida albicansRIRSS10_13Candida albicansRRRRR10_14Trichosporon asahiiSRSSS10_15Candida glabrataRRRRI10_16Candida tropicalisRRRRI10_17Candida albicansSIISS10_18Candida tropicalisRRRRI10_19Candida tropicalisRRRRI10_22Candida glabrataRRRRS10_23Candida tropicalisRRRRR10_25Candida tropicalisRRIRI10_26Candida tropicalisRRRRI10_28Candida albicansRRRRS10_30Candida glabrataRRRRS10_31Candida albicansSIISS11_1Candida albicansSRSRS11_2Candida parapsilosisSSSSS11_3Candida glabrataRRRIS11_6Candida tropicalisRRRRI11_7Candida albicansISISS11_8Candida parapsilosisSRRSS11_9Candida tropicalisRRRRS11_16Candida tropicalisIRRSS11_17Candida tropicalisRRRRS11_18Candida tropicalisRRRRS11_19Candida albicansRIRSS12_1Candida glabrataRRRRS12_2Candida albicansSSISS12_3Candida parapsilosisSSISS12_4Candida tropicalisRRRRS12_6Candida albicansSSISI12_7Candida tropicalisRRRRS12_8Candida tropicalisRRRRS13_2Candida parapsilosisSSSSS13_4Candida tropicalisRRISS13_11Candida glabrataRRRRS13_14Candida albicansSSISS13_15Candida albicansSSISS13_17Candida albicansISIII13_18Candida albicansSRISS13_19Candida tropicalisSRISS13_22Candida albicansSSISS13_23Candida tropicalisRRRSS13_24Candida tropicalisRRIRS13_26Candida parapsilosisRRRRS13_27Candida tropicalisRRRRS13_28Candida albicansSSSSS13_29Candida tropicalisSSISS13_30Candida parapsilosisRRRRS13_32Candida albicansSSISS13_36Lodderomyces sp.RRISS13_37Candida parapsilosisSSIRI13_39Candida albicansSRRRSTable S3 Percentage of in vitro antifungal susceptibility testing of five antifungal agents (viz., clotrimazole, fluconazole, itraconazole, ketoconazole, nystatin) against 157 yeasts isolated during the study.SusceptibilityAntifungal AgentsClotrimazoleFluconazoleItraconazoleKetoconazoleNystatinIntermediate8.917.0025.477.0021.65Resistant52.8663.0566.8743.943.18Susceptible38.2129.937.6448.4075.15Table S4 Comparison of present and previous studies on diversity of yeast in clinical samples around the worldReferenceMeletiadis et al. (2017)Lyon et al. (2010)Basu et al. (2003)Kaur et al. (2016)Present study (2019)Identification MethodsAFLP and ITS Region SequencingTraditionalMicrobiological MethodsTraditionalMicrobiological MethodsTraditionalMicrobiological Methods28S rRNA gene, MALDI-TOF MS and Hi-CromeSpecies observed along with number of isolatesC. albicans (n= 584)C. albicans (n= 2563)C. albicans (n=39)C. albicans (n=33)C. albicans (n=75)C. tropicalis (n= 180)C. tropicalis (n= 180)C. tropicalis (n=21)C. tropicalis (n=37)C. tropicalis (n= 50)C. parapsilosis (n= 122)C. parapsilosis (n= 1032)C. parapsilosis (n=9)C. parapsilosis (n=6)C. parapsilosis (n= 14)C. glabrata (n= 86)C. glabrata (n= 1449)C. glabrata (n=1)C. glabrata (n=9)C. glabrata (n= 22)I. orientalis (n=30)I. orientalis (n=109)I. orientalis (n=6)I. orientalis (n=3)Issatchenkia orientalis (n=2)--C. guilliermondii) (n=3)---C. kefyr (n=6)C. kefyr (n=2)-Candida spp. (n= 97)-------C. africana (n=1)-Cl. lusitaniae (n=76)--Clavispora lusitaniae (n=4)---Cyberlindnera fabianii (n=2)----Trichosporon asahii (n=1)----Kluyveromyces marxianus (n=3)----Lodderomyces sp. (n=1) Kodamaea ohmeri (n=1)Total Strains109958218590176Fig. S1. Representative spectra of T. asahii (10_14), Cy. fabianii (1_27), Ko. ohmeri (6_4), K. marxianus (3_8).T. asahiiCy. fabianiiKo. ohmeriK. marxianusFig. S2. Representative images on chromogenic medium for identification of Candida species. a) Light Green colored colonies of C. albicans. b) Cream colored colonies of C. glabrata. c) Purple fuzzy colored colonies of I. orientalis. d) Bluish green colored colonies of C. tropicalis.Fig. S3. Representative figure of Antifungal susceptibility pattern of C. albicans (3_13) and C. tropicalis (5_1). 0464820Figure S4. Confocal images of invasion of yeasts in HeLa cells. The pseudo-hyphae of Candida tropicalis (strain 10_19) invaded HeLa cells.0590550Figure S5. Confocal images of invasion of yeasts in HeLa cells. The yeast form of Candida parapsilosis (strain 8_20) invaded HeLa cells ................
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