Cannabis Education, Tolerance/Dependence, Dosage, Methods ... - Budzee

Cannabis Education, Tolerance/Dependence, Dosage, Methods, Science, Warnings

WARNINGS:

When under the influence of Marijuana, driving is prohibited by M.G.L. c. 90, ? 24, and machinery should not be operated;

Consumers may not sell Marijuana to any other individual Marijuana has not been analyzed or approved by the FDA, that there is

limited information on side effects, that there may be health risks associated with using Marijuana, and that it should be kept away from children

Note:

See possession and Distribution limits at the end of this document A Log for Tracking Strains/Products and their effects is available at the end

of this document

Cannabis has been used as an herbal remedy for thousands of years and the early literature out of India detailing its benefits has been corroborated by medical science. Mature cannabis plants contain many different cannabinoids, or chemical compounds, that give the user physical and/or psychotropic effects. Each strain or variety of cannabis has a different cannabinoid profile with varying strengths. The body's endocannabinoid system was discovered through research on the cannabis plant, thus the name. Plant cannabinoids mimic endogenous, or naturally occurring cannabinoids, in our body which regulate the immune and nervous system.

Tetrahydrocannabinol (THC)

First synthesized in Israel by Dr. Raphael Mechoulam's team, the therapeutic effects of THC have been well documented in thousands of research papers and human trials. However, only its synthetic analog is approved for pain and nausea by the FDA. THC is known to produce the "high" effect associated with cannabis.

Cannabidiol (CBD)

CBD is the second most prominent cannabinoid. It is popular for its anxiety, pain and insomnia benefits but provides little to no "high".

Things to Consider before consuming:

Everyone has different experiences using marijuana. There are a number of factors that impact the effect you feel including:

Dosage (amount used) Strain or type of cannabis Environment/setting Method of use Mood or mindset Experience/history of marijuana use

Strain Types

Cannabis strains can be divided into four categories: sativa, indica, hybrid and High CBD. Sativa & indica strains have little scientific consensus on the nature of their effect, but colloquially Sativa is a stimulating strain with long wispy buds and thin leaves, and Indica is a sedative strain with round dense buds and wide leaves. Most strains today are a `hybrid' of the two.

CBD Strains

High-CBD Strains are specifically bred to increase the CBD content, therefore maximizing the sedative, calming benefits. CBD is helpful in thousands of reports from consumers in treating pain, inflammation, and anxiety but it is only approved by the FDA for treating epilepsy (Epidiolex from GW Pharma.)

Choosing the Right Strain:

Always ask your bud tender to learn more about effects and how to choose. There is no scientific standard for strain effects. Strain selection is often trial and error as they have different effects on different people.

Delivery & Dosage

Inhalation

The most common method of administration is inhalation via vape or smoked marijuana. When inhaled, cannabinoids enter into the lungs where they quickly pass into your blood stream rapidly- where your lungs then delivery oxygenated blood to the brain so it is a fast delivery to the brain. This makes for a quick onset, but can also be strong, intense, increase anxiety, and strain the lungs.

Vaporizing

Vaporizers heat marijuana flower or oil to a specific temperature (lower than its combustion point - typically 350-400 degrees Fahrenheit. This releases cannabinoids as a vapor without producing smoke. Vaporizing can still cause irritation to the throat or lungs because it often delivers a concentrated amount but it does not deliver smoke which increases inflammation.

Dosage

Vaporizing may require up to twice as much dry cannabis flower to deliver the same effect as other delivery methods. However vaping can be more efficient that smoking so some consumers may actually use less.

If using a concentrate, much less is required. For example, 0.1g of wax might provide 65mg of cannabinoids- triple the dose of an average user might start with during smoking.

Smoking

Smoking is the most common and traditional method of delivery. This is done by smoking cannabis in rolled paper, pipes, or water pipes. Smoking provides users with controllable effects if starting slow which means that many users can slowly increase their dose over time to assess desired dosage and effects.

Dosage

The amount used while smoking varies. The average joint contains 0.5g to 1 gram of cannabis. The average amount used daily also varies from 0.5g-7g or more. Smoking can be done frequently throughout the day as the onset is 5-10 minutes and duration of effect is 2-4 hours.

Ingestion

Cannabis Infused Products First Time Rule of Thumb

Start low and go slow! Start with 5mg or less if it's your first time. Wait at least two hours before having more.

Another popular way to consume cannabis is through ingesting it in edible form. When cannabis is ingested, cannabinoids are metabolized by the liver, which strengthens both the effects and duration of the medicine. Eating or ingesting cannabis usually leads to a longer, stronger, and much more physical effects than smoking. Due to the longer and slower release of cannabinoids, ingestion may cause a stronger dose that wanted. The ability to control the effects (titrate) is more difficult than inhalation because of the variability of digestion and product. Oil tinctures are an alternative to edibles as the oil provides a consistent, predictable effect. The sugars and other ingredients in edibles can change ingestion effects and rates.

Dosage

Start low and go slow is the simple method for any cannabis delivery. Usually, a small puff, a small bite, or a couple drops, followed by a wait period to determine effects (5-10 mins for inhaling and 1-2 hours for ingesting.)

Wait at least two hours to assess the effects before increasing the amount of cannabis consumed, and remember that an empty stomach can significantly affect the time it can take for the cannabis to take effect.

If the effects are too strong, drink water and find a safe and comfortable place to rest. It may take some time but the effects will pass. It is non-toxic to the body but taking too much can be very uncomfortable. Onset of edibles is: 1 - 2 hours and the Duration: 6 - 8 hours

Sublingual Delivery

Some cannabis products are designed for sublingual consumption, including tinctures. "Sublingual" refers to the tissue under the tongue, an area where cannabinoids can enter directly into the bloodstream. Dosing can be easily managed through this discreet, and very effective delivery method.

Dosage

The amount needed will depend on the tincture. Consumers should start with a few drops and increase it as needed. One dropper is equal to 1mL. Onset: 5 - 30 minutes. Duration: 1 - 6 hours. Start with about 5 drops and increase by 5 drops after at least a 3-4 hour wait.

Topicals

Topicals consist mostly of THC and CBD-infused salves, oils, and transdermal patches. Users apply these products directly onto their skin to treat localized pain, muscle soreness, and inflammation. Users with skin disorders or peripheral pain disorders do well with topical cannabis. Cannabinoids are absorbed through the skin and do not result in psychoactive effects. However, a large enough dose of topical THC can be psychoactive.

Dosage

Dose is a function of an area to be covered. Topicals can be used as needed. Onset: Can be instant or take up to an hour to show results. Duration: Varies

Cannabinoid Science:

Chemicals in the cannabis plant called cannabinoids mimic the cannabinoid chemicals humans (and all mammals) produce naturally to regulate two main systems in the body; the immune and nervous system. If you are curious of medical benefits, seek medical advice. You can also search scientific articles on cannabis and certain ailments by searching: [ailment] + cannabinoids + scholarly which will reveal scientifically sound studies on cannabinoids. For example, try searching "rheumatoid arthritis cannabinoids scholarly" and you will find studies on Sativex, a prescription 1:1 THC:CBD drug prescribed in Europe, Australia, South America and soon the U.S.

THC-A

THC-A is the main non-psychoactive cannabinoid in raw cannabis. All THC starts out as THCA and converts to THC when heated, smoked, or vaporized. THC-A has been reported to help with inflammation, seizures, and muscle spasms. The body warms and breaks it down into THC naturally but THCA will tend to be far less psychoactive than THC.

CBD

CBD products are reported to be helpful in treating many conditions while producing very little to no psychoactive effects. It has been used for anxiety, pain, seizures, and inflammation. CBD can be helpful for those wanting less psychoactivity.

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