Possible Side Effects of EPOCH (Etoposide, Prednisone ...



Possible Side Effects of EPOCH (Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin) (Table Version Date: April 10, 2019)COMMON, SOME MAY BE SERIOUSIn 100 people receiving EPOCH (Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin), more than 20 and up to 100 may have:High blood pressure which may cause headaches, dizziness, blurred visionInfection, especially when white blood cell count is lowBruising, bleedingAnemia which may cause tiredness, or may require blood transfusionsBlood in urineRed colored urine, saliva, or sweatIn children and adolescents: decreased heightSwelling of the bodyNausea, vomiting, constipation, diarrhea, loss of appetite, pain in bellyIncreased appetite and weight gain in the belly, face, back and shouldersSores in mouthAbsence of menstrual period which may decrease the ability to have childrenLoss of bone tissueMood swingsNumbness and tingling of fingers or toesWeakness and difficulty walkingHeadache, jaw pain and/or muscle painDifficulty sleepingTirednessPain or redness at the site of injectionHair loss, skin changes, rash, change in nailsOCCASIONAL, SOME MAY BE SERIOUSIn 100 people receiving EPOCH (Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin), from 4 to 20 may have:Heart failure or heart attack which may cause shortness of breath, swelling of ankles, cough or tiredness which may occur years after the doseAbnormal heartbeatFluid around the heartSeizureDamage to the lungs which may cause shortness of breath when combined with radiationScarring of the lungs which may cause shortness of breathBlood clot which may cause swelling, pain, shortness of breathDamage to the bone marrow (irreversible) which may cause infection, bleeding, may require transfusionsHepatitis or damage to the liver which may cause yellowing of eyes and skin, swellingKidney damage which may require dialysisKidney stonesDiabetesVisual lossBlurred vision with chance of blindnessCloudiness of the eye, visual disturbancesGlaucomaA tear or a hole in the bowels which may cause belly pain or that may require surgeryHeartburnDifficult swallowingAllergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throatLoss or absence of sperm which may lead to an inability to father childrenDamage to the bone which may cause joint pain and loss of motionMuscle weaknessSwelling that may be accompanied by confusion, and dizzinessParalysis, weakness, headache, confusionDifficulty with balance and hearingStuffy noseHoarsenessDrooping eyelidsSevere skin rash with blisters and peeling which can involve inside of mouth and other parts of the bodyNon-healing woundDarkening of the nail beds or skin or hands and feetDamage to the skin which may cause painRARE, AND SERIOUSIn 100 people receiving EPOCH (Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin), 3 or fewer may have:Cancer of the bone marrow (leukemia) caused by chemotherapySevere blood infectionBleeding from sores in the stomachBroken bones ................
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