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A. Mesut Erzurumluoğlu

Date of Birth: xx/xx/1988

Place of Birth: Ankara, Turkey

Nationality: British and Turkish (Dual citizenship)

Address: Genetic Epidemiology Group, Department of Health Sciences, University of Leicester,

Centre for Medicine, University Road, Leicester, LE1 7RH, UK

Tel No: 07xxx

Email Address: epmmee@my.bristol.ac.uk (Academic)

m.erz@ (Personal)

Education/Research: (Reverse Chronological Order)

Postdoctoral Research Associate - University of Leicester, Leicester (Nov 2015 - Dec 2017)

Postgraduate (PhD) - University of Bristol, Bristol (Feb 2012 - Nov 2015)

Undergraduate (BSc) - University of Leicester, Leicester (Oct 2007 - Jul 2011)

Sixth Form College (A levels) - Leicester Montessori Grammar School, Leicester (Sept 2006 - Jul 2007)*

- Wyggeston & Queen Elizabeth I College, Leicester (Sept 2004 - Jul 2006)

Selected Qualifications: (Reverse Chronological Order)

Postgraduate Course (Feb 2012- Nov 2015)

|PhD Genetic Epidemiology |Full scholarship by the MRC |

|(Nov 2015) |3+1 year PhD course |

Undergraduate Course (2007-11)

|BSc Biological Sciences (Genetics) |Upper Second Class Honours (2.1) |

|(Jul 2011) |Distinction in Final year Project |

A Levels (2004-07) – Best possible grade in 2006: A

|Mathematics (Aug 2006) |A |2004-06 |

|Further Maths (Aug 2006) |B |2004-06 |

|Electronics (Aug 2006) |A |2004-06 |

|Physics (Aug 2006) |B |2004-06 |

|*Biology (Aug 2007) |B |2006-07 |

*as an external student

Academic Publications: (as of Mar 2017)

First, Equal-first (*) and/or Senior/Corresponding (ᶧ) authorship (IF: Impact factor of journal at time of publishing)

1- Alsaadi MM*, Erzurumluoglu AM*, Rodriguez S … Day IN. Nonsense mutation in coiled-coil domain containing 151 (CCDC151) gene causes Primary ciliary dyskinesia. Dec 2014. Human Mutation. 35 (12), 1446-1448. (IF: 5.14)

2- Erzurumluoglu AMᶧ, Alsaadi MM, Rodriguez S, Alotaibi TS … Day IN. Proxy molecular diagnosis from whole-exome sequencing reveals Papillon-Lefevre syndrome caused by a missense mutation in CTSC. Mar 2015. PLoS One. (IF: 3.53)

3- Erzurumluoglu AM, Rodriguez S, Shihab HA, Baird D, Richardson TG, Day IN, Gaunt TR. Identifying highly-penetrant disease causal mutations using next generation sequencing: Guide to whole process. Apr 2015. BioMed Research International. Article ID: 923491. (IF: 2.71)

4- Erzurumluoglu AMᶧ, Shihab HA, Rodriguez S, Gaunt TR, Day IN. Importance of genetic studies in consanguineous populations to characterization of novel human gene function. Apr 2016. Annals of Human Genetics. (IF: 2.21)

5- Erzurumluoglu AM, Baird D, Richardson TG, Timpson NJ, Rodriguez S. Novel uses of Y chromosomal haplogroups in genetic association studies and suggested implications. Submitted. Pre-print available at BioRxiv.

Middle-authorship

6- Wain LV, Shrine N, Soler-Artigas M, Erzurumluoglu AM … Strachan DP, Hall IP & Tobin MD. Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Published online 6th Feb 2017. Nature Genetics. (IF: 31.616)

Key role: Lead functional follow-up studies (e.g. eQTL, biological pathway analyses, druggability, pleiotropy, protein-protein interactions) and appropriate visualisation of GWAS results (Manhattan & Circos plots)

7- Zheng J, Erzurumluoglu AM, Elsworth B … Gaunt TR, Evans DM, Neale B. LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Sept 2016. Bioinformatics. (IF: 5.766)

8- Warren HR, Evangelou E, Cabrera CP … Erzurumluoglu AM … Elliott P, Caulfield MJ. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Published online 30th Jan 2017. Nature Genetics. (IF: 31.616)

9- Zheng J, Rodriguez S, Laurin C, Baird D, Trela-Larsen L, Erzurumluoglu MA … Evans DM, Gaunt TR, Day INM. HAPRAP: a haplotype-based iterative method for statistical fine mapping using GWAS summary statistics. Sept 2016. Bioinformatics. (IF: 5.766)

10- Howe LJ, Erzurumluoglu AM, Davey-Smith G, Rodriguez S, Stergiakouli E. Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population. Submitted. Pre-print available at BioRxiv.

11- Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM … Caulfield MJ, Ehret G. Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney. Submitted. Pre-print available at BioRxiv.

*Others are concealed as manuscripts are not yet published/deposited

Academic Teaching/Supervision:

- University of Leicester (Department of Health Sciences) Lecture/Tutorial: Population Science (17 Nov-1 Dec 2016 & 21-23 Mar 2017)

o Global Health – 4 hour teaching/tutorial session to undergraduate students

o Occupation, Environment and Health – Same as above x 2 sessions

o Study designs (e.g. cohort, case-control) and Science communication – Same as above x 3 sessions

- University of Bristol School of Social and Community Medicine (SSCM) miniprojects (Dec 2015-Present)

o Identifying Primary ciliary dyskinesia causal variants in consanguineous families – Role: Co-supervisor

o The role of Y chromosome and mitochondrial DNA haplogroups in cardiovascular disease – Role: Co-supervisor

- University of Bristol SSCM Short Course: Introduction to Genetics and Genomics (24-25 Mar 2014 & 13 Apr 2015)

o Mendelian Inheritance – 1 hour lecture to a class consisting of PhD students and senior research staff

o SNP, Sequence and Mutation databases – Same as above

- University of Bristol SSCM Short Course: Genetic Epidemiology (14-17 Apr 2015)

o Analysing DNA sequencing data – Same as above

- Identifying Mendelian disorder causal variants – 1 hour practical following on from the above lecture

- Supervision of two research interns: ~3 months (Jun - Aug 2014)

o Wet-lab based methods (e.g. PCR, Mutation screening methods, Gel electrophoresis)

o Carrying out literature reviews on Primary ciliary dyskinesia and Autosomal recessive Intellectual disability

Selected Projects: (Reverse Chronological Order)

1- Genome-wide association studies of lung function (and Chronic obstructive pulmonary disease, COPD), blood pressure and smoking behaviour related traits – Nov 2015 to Present

Identifying genetic predictors for lung function (and smoking behaviour) and understanding the genetic aetiology of common diseases/disorders such as COPD and hypertension

Supervisors: Dr. Louise Wain and Prof. Martin Tobin (Univ. of Leicester, Genetic Epidemiology Group)

2- Population and family based studies of Consanguinity: Genetic and Computational approaches – Jan 2013 to Jan 2016

Analysing whole-exome sequencing data obtained from consanguineous families/individuals; and the identification of causal variants of rare human diseases. Also carrying out theoretical studies on the effects of consanguinity per se and how consanguineous populations can be used to further advance our understanding of the human genome

Supervisors: Dr. Santiago Rodriguez, Dr. Tom Gaunt and Prof. Ian Day (Univ. of Bristol, BGEL)

3- Can non-recombining paternal/maternal ancestry inform genetic association studies? – Jan 2012 to Jul 2015

Analysing subgroups of individuals stratified according to their non-recombining ancestry as an attempt to explain some of the ‘missing heritability’ observed for many common complex diseases (e.g. epistasis and/or epigenetic markers)

Supervisors: Dr. Santiago Rodriguez and Dr. Nicolas Timpson (Univ. of Bristol, BGEL and MRC IEU)

4- Role of Iron in Fungal Pathogenicity – Oct 2010 to May 2011

Analysing the SEF1 gene in Candida albicans (fungus) and studying its role in iron homeostasis

Supervisor: Prof. Annette Cashmore (Univ. of Leicester, Dept. of Genetics)

Skills Gained from Projects:

Wet-lab based

- DNA extraction and quantification

- Mutation screening (e.g. PCR-RFLP, ARMS-PCR)

- Primer designing, PCR and Gel Electrophoresis (including 96-well MADGE)

- Cell culture (i.e. E. coli and C. albicans) and transformation

In silico

- Manage large data using the Python and R/R-studio programming languages and automate via bash scripts

- Autozygosity/homozygosity mapping using genotype and/or sequencing data (e.g. Plink, AutoZplotter)

- Use of public databases (e.g. 1000 Genomes, Exome Variant Server, HGMD, ENCODE, GTEx, CHi-C)

- SNP, Indel and CNV detection from sequencing data (e.g. SOAPsnp, SAMtools, GATK, Control-FREEC)

- Mapping reads to the human reference genome (using BWA) and Variant annotation (e.g. Ensembl VEP)

- Mutation effect prediction (e.g. FATHMM, SIFT, PolyPhen-2, CADD, Human Splice Finder)

- Modelling Protein structure and Predicting Protein-Protein interactions (e.g. Robetta, STRING, KEGG)

- Carry out a Genome-wide association study (GWAS) including QC steps, visualization (incl. Manhattan and Circos plots), imputation (using MaCH, IMPUTE2, R-studio packages), functional follow-up (e.g. eQTL databases), haplotype phasing (e.g. BEAGLE) and meta-analysis (using RAREMETAL)

- Statistical analysis using R, Stata and Plink (e.g. linear/logistic regression, interaction/likelihood ratio test)

- Determining Y chromosomal and Mitochondrial haplogroups (using HaploGrep, Phylotree, YFitter)

- Building Phylogenetic trees, Homology BLAST and multiple alignment at protein and nucleotide level

- Biological pathway analyses and Drug target databases (e.g. ConsensusPathDB, DrugBank, ChEMBL)

Academic Membership

- Community Genetics Network (The Netherlands Association of Community Genetics and Public Health Genomics) – since Apr 2016

Academic Conferences: (Reverse Chronological Order)

- Target Validation Using Genomics and Informatics, 4-6th Dec 2016: Heidelberg, Germany (Poster presentation)

- IV International Scientific Conference of Young Researchers, 29-30th Apr 2016: Baku, Azerbaijan (Invited “Keynote” talk)

- American Society of Human Genetics (ASHG) Conference, 18-22nd Oct 2014: San Diego, USA (Poster presentation)

Academic Collaborations Initiated/Joined:

- Consortium for the Genetics of Smoking Behaviour (Apr 2016-Present) – Role: Co-author and lead data analyst for the Genetic Epidemiology Group at the University of Leicester (Leicester, UK)

- CHARGEmtDNA+ cohort (Jun 2015-Present) – Role: Co-author and one of the data analysts for ALSPAC (University of Bristol, Bristol, UK)

Selected Scholarship/Bursary/Grants/Posts: (Reverse Chronological Order)

|Bursary/Post (or Course) |Dates |Worth |Source/Reason |

|Qafqaz University Travel Grant |29th Apr 2016 to 30th Apr 2016 |~£1500 |Speaker at the IV International Scientific Conference|

| | | |of Young Researchers organized by the Qafqaz |

| | | |University (Azerbaijan) |

|Computational Biologist - Postdoctoral |2nd Nov 2015 to 1st Dec 2017 |~£33000 per annum |By the University of Leicester via external funding |

|Research Associate | | |from the MRC (Medical Research Council) |

|MRC Skills Training Grant |12th Oct to 16th Oct 2015 |£775 |By the MRC for training at the European |

| | | |Bioinformatics Institute, Cambridge, UK |

|The Genome Access Course (TGAC) |30th Mar to 1st Apr 2015 |~£1500 |By the MRC for training at Cold Spring Harbor |

| | | |Laboratory, New York, USA |

|European Union Mobility Grant |21st to 26th Apr 2013 |€500 |5-day INBIOMEDvision course in Translational |

| | | |Bioinformatics at the Barcelona Supercomputing |

| | | |Center, Spain |

|MRC (Medical Research Council) |30th Jan 2012 to 1st Feb 2016 |~£21000 per annum |4-year PhD course in Genetic Epidemiology at the |

|Scholarship | | |University of Bristol, Bristol, UK |

|Eliahou Dangoor Scholarship |Sept 2007 |£1000 |By the University of Leicester for A level results |

| | | |and studying STEM subjects, Leicester, UK |

|ACES Maintenance Bursary |Aug 2004 to June 2009 |All living costs (e.g. |Anatolia Cultural and Educational Society (ACES) |

| | |accommodation, travel and food) |based in Leicester, UK for being a role model to |

| | |~£7000 per annum |youngsters in the community |

Academic Peer-reviewing:

- FEBS (Wiley) – 2015

- Clinical Laboratory (Clinical Laboratory Publications) – 2013

- Case Reports in Endocrinology (Hindawi) – 2014

Selected Awards: (Reverse Chronological Order)

- Success School (Dec 2012) by Dialogue Society *for Chairing/presenting the ‘Success School’ events

- Mentoring Scheme (May 2011) by University of Leicester *for mentoring five 1st year undergraduate students

- Teacher of the Year (Aug 2008) by Horizon Weekend School *chosen by attending students

- Science Exhibition (May 2008) by Midland Forum *for best scientific project presentation

- Student of the Year (Jun 2006) by Leicester Supplementary Schools Trust

- Mathematics Master Class (Feb 2003) by Leicester Excellence in Cities

- Gifted and Talented (twice, in Feb 2002 and Jan 2003)

- Learning Performance (Feb 2002) *given to students with highest potential

Selected Work Experience: (Reverse Chronological Order) *Paid work

- Volunteer Member of the Dialogue Society - Bristol & Leicester branches (Aug 05-Mar 16)

- Assistant Teacher for Horizon weekend school (Aug 04-Jan 07) located in Leicester, then promoted to Teacher role at the start of 07/08 teaching season (Jan 07-Jan 11); also worked for AXIS supplementary school - Bristol branch (Jan 12-Jan 13)

- *Take-away shops (TJs - Queens Rd and Melton Rd branches) located in Leicester (Apr 05-Sept 06 & Dec 10-Jul 11)

- *Freelance proof-reading (e.g. essays, dissertation, theses), translation and interpretation (Sept 07-Sept 11)

- Secretary (and one of the founders) of Anatolia Football Club (Leicester Sunday League) (Aug 07-Mar 10)

- *School link worker for Anatolia Cultural and Educational Society located in Leicester (Sept 07-Sept 08)

- Completed a two-week course at Bacons Shoes (South Wigston, Leicester) as a Retail assistant (6-18th Oct 03)

- Other miscellaneous jobs: *One-to-one tuition, Weekly supplementary classes, *PC troubleshooting, Caretaker (Jun 06-Jun 09)

Skills Gained from Work Experience:

- Respecting others’ opinions (Dialogue Society)

- Ability to Change with accumulating knowledge (School link worker, Dialogue Society)

- How to Present own ideas (School link worker, Dialogue Society)

- Coming up with Innovative ideas to help people (School link worker)

- Listening to and/or Obeying/respecting managers’ decisions (Bacons Shoes, Take-away shops)

- Working Long hours in Busy schedules (Take-away shops)

- Versatility (obtained from a variety of work and/or voluntary environments)

- Working in Groups; and Individually (Dialogue Society)

- Organising groups of individuals (Teacher)

- Writing Reports & filling forms (Secretary of Anatolia FC)

Academic Career Aspirations:

Short-term objectives:

Take part in research projects to widen my scope in the area of Genetic Epidemiology and related areas (e.g. Population Genetics, Cancer Genetics, Epigenetic Epidemiology, Lifecourse Epidemiology)

Long-term objectives:

Start teaching the knowledge I have gained to other Biological Sciences, Epidemiology and/or Genetics students, while also taking leading roles in projects which could potentially help mankind (e.g. identifying drug targets, diagnostics)

Selection of Courses/Workshops attended: (Reverse Chronological Order)

|Course/Workshop |Dates |Topics covered (overview) |Organisers |

|Structural Bioinformatics |12th Oct to 16th Oct 2015 |Protein structure, protein-protein |EMBL-EBI, European Bioinformatics Institute, Cambridge,|

| | |interaction |UK |

|Design and Analysis of Randomised |15th Jun to 19th Jun 2015 |Study designs, Health economics, |University of Bristol, School of Social and Community |

|Controlled Trials (RCT) Course | |Qualitative research, Subgroup |Medicine, Bristol, UK |

| | |analysis | |

|The Genome Access Course (TGAC) |30th Mar to 1st Apr 2015 |Sequence/Gene/Protein resources, |Cold Spring Harbor Laboratory, New York, USA |

| | |Comparative genomics, RNA-Seq data,| |

| | |Genetic pathway analysis | |

|Mendelian Randomisation (MR) Course |5th Feb 2015 |Study design, Bias, Interpretation |University of Bristol, School of Social and Community |

| | |of results |Medicine, Bristol, UK |

|Lifecourse Epidemiology Course |12th Nov 2014 |Plots, Path analysis, Multilevel |University of Bristol, School of Social and Community |

| | |models |Medicine, Bristol, UK |

|A journey through the Bioinformatics |29th Oct 2014 |Building a pipeline for NGS data |Royal College of Pathologists, London, UK |

|pipeline | |analysis | |

|Epigenetic Epidemiology Course |23rd to 25th Apr 2014 |Study designs, Bioinformatics |University of Bristol, School of Social and Community |

| | |resources, Interpreting findings |Medicine, Bristol, UK |

|Systematic Reviews and Meta-analysis |13th to 16th Jan 2014 |Performing comprehensive searches, |University of Bristol, School of Social and Community |

|Course | |Analyses using Stata, Risk of bias |Medicine, Bristol, UK |

|Data Management for Health Research |27th to 29th Nov 2013 |Clinical database building, SOPs |University of Bristol, School of Social and Community |

|using MS Access Course | |and Risk assessment |Medicine, Bristol, UK |

|Statistics in Medicine MOOC |17th to 28th June 2013 |Study designs, Regression analyses,|Stanford University, California, USA via Stanford |

| | |Statistical inference, Probability |Online Lagunita |

| | |distributions | |

|MRC Human Tissue Handling Online |20th June 2013 |Best practice, Acts, Support |MRC, UK via mrc.ac.uk |

|Course | | | |

|Advanced Stata Course |7th to 8th May 2013 |Manipulate datasets, Automation of |University of Bristol, School of Social and Community |

| | |tasks |Medicine, Bristol, UK |

|Translational and Integrative |21st to 26th Apr 2013 |Clinical application of genomic |INBIOMEDvision at the Barcelona Supercomputing Center, |

|Bioinformatics Postgraduate Course | |information, Systems biology |Spain |

|Critical Appraisal of Quantitative |22nd Mar 2013 |Structured appraisal of published |University of Bristol, School of Social and Community |

|Research Course | |studies and bias |Medicine, Bristol, UK |

|R Programming MOOC |27th Sept to 19th Oct 2012 |R functions, Debugging, Simulation |Johns Hopkins Bloomberg School of Public Health, |

| | | |Maryland, USA via Coursera |

|Software Carpentry Course |13th to 14th Sept 2012 |Python programming, Using the |University of York, York, UK |

| | |shell, Debugging | |

|Advanced Epidemiological and |25th to 29th June 2012 |Causal diagrams, Analyses using |University of Bristol, School of Social and Community |

|Statistical Methods Course | |Stata, Study designs and models |Medicine, Bristol, UK |

|Genetic association studies and |28th May to 1st June 2012 |GWAS, Linkage studies, Population |University of Bristol, School of Social and Community |

|Advanced Genetics Course | |genetics, Complex trait genetics |Medicine, Bristol, UK |

|Introduction to Statistics and |14th to 18th May 2012 |Conceptual understanding, Stata |University of Bristol, School of Social and Community |

|Linear/Logistic regression models | |commands, Interpretation of results|Medicine, Bristol, UK |

|Course | | | |

Interests & Hobbies:

- Improving the social conditions of disadvantaged people and communities

- Learning new things and educating youngsters

- Sports (especially Football, Tennis/Squash and Swimming) and Travelling

- Besides the field of Genetics as-a-whole and related areas (e.g. Epigenetics), follow latest developments in Ancient History, Archaeology, Astronomy and Quantum Physics (via magazines, blogs, MOOCs)

Additional Information:

I also:

- Have exceptional computational (both in Windows and UNIX based operating systems) and MS Office/Adobe Photoshop operational skills (e.g. designed several websites, many brochure/posters/logos)

- Am one of the founders and the first President of the University of Bristol Turkish Society (Dec 2012 - Apr 2014), then became the IT manager (Apr 2014 - Apr 2015); and was also one of the founders and the IT Manager of the University of Leicester (UoL) Turkish Society (Sep 2007 - Jun 2011). I am currently the President of the UoL Turkish Society (Mar 2016-Present)

- Completed a Student Leader Masterclass (Nov 2016)

- Can speak, read and write in English (Bilingual proficiency) and Turkish (Natural); also speak and read in French (Elementary) and Arabic (Elementary)

- Took part in many public engagement and/or career events to convey our research to children and young adults, with the aim of inspiring them to become scientists/researchers

- Wrote (or contributed to) science, health and success related articles/posts for the lay public in various US, UK and Turkey based journals, online blogs and local newspapers (e.g. The Fountain, Leicester Mercury, Hiyerarşi) - several being invited and/or paid.

- Hold a Full UK driving license (since Mar 2009)

- Have successfully completed a Health and Safety (Level 2) Course (Sep 2006)

- Have completed a Level 1 First-Aid course (Mar 2009)

- Won Gold at College Olympics by running 100m in 12 seconds (May 2002)

- Captained and also was the Top Goalscorer of a local football club (Anatolia FC) in Leicester (Aug 2007 - Feb 2010)

Referees:

Dr. Alex Rodriguez

Senior Lecturer

Dept. of Medicine, University of ABC

abc@abc.ac.uk

01161234567

Prof. David Rodriguez

Professor

Department of Health Sciences, University of Leicester

def12@leicester.ac.uk

01168901234

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