MOLECULAR BIOLOGY PART-2 GENE GENECONCEPTGENE …
MOLECULAR BIOLOGY PART-2
GENE GENE CONCEPT PROTEIN SYNTHESIS LAC OPERON CONCEPT
GENE AND GENE CONCEPT
To know about the scientists who coined various terminologies and proposed gene hypothesis
Gene was coined by
W Johansen in 1909
Gene theory was proposed by
T H Morgan in 1911
L Pauling and Ingram(1949) established the role of genes in protein synthesis
The fine structure of gene
was proposed by Seymour Benzere(1962) GENE ? CISTRON ? RECON ? MUTON
E R Garrod (1908) proposed
One gene ? one product hypothesis
G W Beadle and E L Tatum
(1948) proposed
One gene ? one enzyme hypothesis
Yanofsky (1965) proposed
One gene ( cistron) ? one polypeptide hypothesis
PROKARYOTIC GENE (Unspilt gene)
Has only coding exons
C1 E C2 E C3 E
EUKARYOTIC GENE
(spilt gene) Has only coding exons
and non coding introns
Transcription
E
IE IE
E
E
E
Transcription
E
I
EI E
(Polycistronic mRNA)
Translation
I
( Hn ? RNA) RNA Splicing
I
E
E
E
(Monocistronic mRNA)
Translation
Many polypeptides or proteins
One protein
(spilt gene ? Philip A Sharp and Richards Roberts- 1979, Noble prize 1993)
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