School of Medicine | University of Colorado



OLGA KLEPITSKAYA, MD

Clinical practice:

University of Colorado Hospital

Anschutz Outpatient Pavilion

1635 Aurora Ct.,

Aurora, CO 80045

Phone: 720-848-2080

Veteran Affairs Medical Center

Eastern Colorado Healthcare System

1055 Clermont St.

Denver, CO 80220

Phone: 303-393-2874

Academic practice:

University of Colorado Denver

Department of Neurology, Mail Stop B-185,

12631 E 17th Ave, Room 5210,

Aurora, CO 80045

Phone: 303-724-2194 Fax: 303-724-2212

Olga.Klepitskaya@ucdenver.edu

Research affiliation:

Clinical Translational Research Clinic

12401 E 17th Ave, B141,

Aurora, CO 80045

PERSONAL INFORMATION

Naturalized US citizen since 2005, permanent resident of the US since 1998.

Born in Khabarovsk, Russia

EDUCATION

09/1973 - 06/1983 School #5, Khabarovsk, Russia.

Graduated with Gold Medal, GPA 5.00 Of 5.00

09/1983 - 06/1989 Far Eastern State Medical University (Khabarovsk State Medical Institute)

Khabarovsk, Russia. Degree of Medical Doctor, Graduated Summa Cum Laude, GPA 5.00 of 5.00

09/1989 - 10/1996 Residency in Neurology

Far Eastern State Medical University, Khabarovsk, Russia

06/2001- 06/2002 Internship in Internal Medicine

Resurrection Medical Center, Westlake Hospital, Melrose Park, Illinois

07/2002 - 06/2005 Residency in Neurology

University of Colorado Denver, Denver, Colorado

07/2005 - 07/2006 Fellowship in Movement Disorders

Comprehensive Movement Disorders Center, Stanford University Medical Center, Stanford, California

WORK HISTORY: CLINICAL/ACADEMIC EXPERIENCE

1989 - 1990 Research Associate

Central Research Laboratory

Far Eastern State Medical University, Khabarovsk, Russia

09/1989 - 10/1996 Teaching Assistant in Neurology

Department of Neurology, Far Eastern State Medical University, Khabarovsk, Russia

02/1990 - 05/1992 Instructor of Neurology

Department of Speech Therapy and Speech Disorders,

Khabarovsk State Pedagogical University, Khabarovsk, Russia

06/1994 - 04/1998 Attending Neurologist

Far Eastern State Medical Center, Khabarovsk, Russia

06/1994 - 04/1998 Instructor of Neurology and Neurophysiology

Far Eastern State Medical University, Khabarovsk, Russia

12/1996 - 04/1998 Neurophysiologist, Director of Electroencephalography Laboratory

Department of Neurodiagnostics, Far Eastern Medical Center, Khabarovsk, Russia

06/1998 - 01/1999 Research Assistant

Department of Neuroscience, Sleep Laboratory

Washington State University, Pullman, WA

08/2000 - 06/2001 EEC technician

Gritman Medical Center, Moscow, Idaho

09/2006 - 06/2008 Clinical Instructor of Neurology

University of Colorado Denver, Aurora, CO

05/2007 – 06/2008 Attending Neurologist

The Children’s Hospital, Aurora, CO

06/2007- present Staff Neurologist, Director of Parkinson Centers of Excellence (PADRECC)

Veteran Administration Hospital, Denver, CO

09/2007- present Attending Neurologist

University of Colorado Hospital, Aurora, CO

07/2008 - present Assistant Professor of Neurology

University of Colorado Denver, Aurora, CO

07/2008 - present Co-Director

University of Colorado Hospital Deep Brain Stimulation Center, Aurora, CO

OTHER RELATED EXPERIENCE

1983-1990 Medical Journalist and Editor

Far Eastern TV and radio Company, Khabarovsk, Russia

08/1992 - 05/1994 Director of Public Relations Department

Association of Medical Workers of the Khabarovsk Region, Khabarovsk, Russia

1999 – 2001 Medical and Social Interpreter, Russian–English

Washington State Department of Social and Health Services, Spokane, WA

02/2000 - 08/2000 Medical Consultant

Ukrainian-American Educational Project,

Washington State University, Pullman, WA

HONORS AND AWARDS

• Gold Medal for Excellence (High School, 1983)

• First Place Award of All-Russian Academic Olympiad in Chemistry (1983)

• Federal Highest Individual Scholarship, named by V.I. Lenin (09/1985 - 06/89)

• Graduated with Honors, Far Eastern State Medical University (06/89)

• Research Abstract Selected as a “particularly important development in the field” from 10th International Congress on Alzheimer’s & Parkinson’s Diseases by Faculty of 1000, information about Faculty of 1000 can be found at (03/2011)

• American Neurological Association’s Translational and Clinical Research Course for Clinician-Scientists Scholarship, Baltimore, MA, (05/2011), declined attendance

• National Institute of Neurological Disorders and Stroke (NINDS) Clinical Trial Methods Course (CTMC) in Neurology Fellowship, Vail, CO (08/11)

AD HOC REVIWER

• American Journal of Speech Language Pathology

• Cephalgia

PUBLICATIONS

Klepitskaya OS, Shishmakov, YV. Biological Activity of Pine-Tree Oil. Questions of the

Ecological Biochemistry and Physiology;1988: 45-49

Klepitskaya OS, Ottieva EN. Neurological Disorders in Patients with Lupus Erythematosus. Far Eastern Medical Journal;1998(2):67-68

Klepitskaya OS, Rykova MG. Modern Clinical Variations of Conversion Disorder. Topics in

Psychopathology. Publication of the Russian Institute of Mental Diseases named after Serbskiy;1998:22-28

Kluger BM, Klepitskaya O, Okun MS. Surgical Treatment of Movement Disorders. Neurologic Clinics of North America;2009:633-677

Klepitskaya O. Parkinsonism- Hyperpyrexia syndrome. In: Kompoliti K, and Verhagen Metman L (eds.) Encyclopedia of Movement disorders. 2010; vol. 1, pp. 399-401 Oxford: Academic Press

Klepitskaya O. Dopamine Dysregulation syndrome. In: Kompoliti K, and Verhagen Metman L (eds.) Encyclopedia of Movement disorders. 2010; vol. 1, pp. 323-326 Oxford: Academic Press

Patel SG, Stickrath CR, Anderson M, Klepitskaya O. How Should Parkinson’s Disease be Managed Perioperatively? The Hospitalist. 2010;15(6):19-22

Klepitskaya O.S., Cole W., Henderson, J., Bronte-Stewart, H. Deep Brain Stimulation in “On”- Parkinson Hyperpyrexia. Neurology. 2011;76(7): s69-s71

Spielman, J., Mahler, L., Halpern, A., Gilley, P., Klepitskaya, O., and Ramig. Intensive Voice Treatment (LSVT®LOUD) for Parkinson's disease following Deep Brain Stimulation of the Subthalamic Nucleus. Journal of Communication Disorders. 2011;doi:10.1016/j.jcomdis.2011.05.003

POSTER PRESENTATIONS AND ABSTRACTS

Klepitskaya OS, Maa EH, Tyler KL. Delayed Seroconversion in Immunocompromised Patient with West Nile Virus-Associated Brainstem Encephalitis. 57th Annual Meeting of the American Academy of Neurology, April 2005, Miami, Fl, USA

Klepitskaya OS, Proskokova TN. Hepatolenticular Degeneration: Wilson- Konovalov’s Disease. 58th Annual Meeting of the American Academy of Neurology, April 2006, San Diego, CA, USA

Neurology;2006(66):A2

Grenier Y, Spielman JL, Klepitskaya OS, Ramig LO, Henderson JM, Bronte-Stewart HM. Methodology for objective motor speech assessment outcome after deep brain stimulation for Parkinson’s disease. 10th International Movement Disorders Congress, Kyoto, Japan, October 2006 Movement Disorders;2006(21):S655

Klepitskaya OS, Cole WL, Bronte-Stewart HM Evolution of Parkinson disease during 4 years of Deep Brain Stimulation: a case report. 10th International Movement Disorders Congress, Kyoto, Japan, October, 2006 Movement Disorders;2006(21):S665

Klepitskaya OS, Fischbein NJ, Hall DA, Bronte-Stewart HM. Superficial Siderosis with supranuclear palsy, parkinsonism and falls. 10th International Movement Disorders Congress, Kyoto, Japan, October, 2006Movement Disorders;2006(21):S525- S526

Klepitskaya OS, Cole WL, Henderson JM, Bronte-Stewart HM. Deep brain stimulation decreases the risks for Parkinsonism-Hyperpyrexia syndrome and suppresses levodopa-induced dyskinesias: a case report. 10th International Movement Disorders Congress, Kyoto, Japan, October, 2006.Movement Disorders;2006(21):S666-S667 and Annual meeting of Parkinson Study Group, Chicago IL, USA, 2006 Movement Disorders;2006(21):1552

Richardson MD, Ojemann SG, Klepitskaya OS. Response of the subthalamic nulcleus neurons to vocalization. 11th International Movement Disorders Congress, Istanbul, Turkey, June 2007.Movement Disorders;2007(22):S53 and 1st international symposium “Basal ganglia speech disorders and Deep Brain Stimulation”, July 2007, London, UK

Klepitskaya OS, Kim Z, Richardson MD, Ojemann SG. Three-dimensional computerized model of subthalamic nucleus. 12th International Movement Disorders Congress, Chicago, IL, USA, June 2008.Movement Disorders;2008(23):S108 – Poster was selected for guided poster tour

Klepitskaya O, Kumar R. Efficacy and Safety of Low Level Electromagnetic Fields Treatment in Parkinson’s Disease. Annual meeting of Parkinson’s Study Group, Salt Lake City, UT, USA. Movement Disorders;2008(11):1633

Klepitskaya OS, Fowler JJ, Kluger BM, Ojemann SG. Number of microelectrode recording passes during bilateral staged vs. unstaged deep-brain stimulation surgery for Parkinson's disease. 13th International Movement Disorders Congress, Paris, France, June 2009. Movement Disorders;2009(24):S485-S486

Klepitskaya OS, Koop MM, Bronte-Stewart HM. Longitudinal study of Microlesion Effect on Bradykinesia after Subthalamic Nucleus Deep Brain Stimulation Surgery for Parkinson's disease. 13th International Movement Disorders Congress, Paris, France, June 2009 Movement Disorders;2009(24):S485

Reid KA, Hoyt B, Tanabe J, Ojemann SG, Legenska A, Klepitskaya OS. Prevalence of dopamine dysregulation syndrome in Parkinson’s disease patients-candidates for deep brain stimulation. 14th International Movement Disorders Congress, Buenos Aires, Argentina, June 2010 Movement Disorders;2010(25):S282

Klepitskaya OS, Hoyt B, Berk JJ, Ojemann SG. Reversible cognitive impairment induced by deep brain stimulation of subthalamic nucleus. 14th International Movement Disorders Congress, Buenos Aires, Argentina, June 2010 Movement Disorders;2010(25):S446

Pelak VS, Choi M, Jung S, Halliday B, Hager E, Klepitskaya O, Ojemann S, Filley C, Dubin M.

“Visuospatial Assessment By Virtual 3D Radial Optic Flow Illusion In Healthy Aging, Mild

Alzheimer’s Disease (AD), And Pre-Deep-Brain Stimulation (DBS) Parkinson’s Disease (PD)

Subjects.” Abstract A-316-0002-01523. 10th Annual International Conference on Alzheimer’s and

Parkinson’s Disease. Barcelona, Spain. March 9-13th, 2011

Hall D, Klepitskaya OS, Tassone F, Spector E, Leehey M. FXTAS in Patients with Fragile X Gray Zone

Alleles. 63rd Annual AAN Meeting, Honolulu, Hawaii, March 2011. Neurology; 2011(76)9:SA399

O.S. Klepitskaya, Z. Kim, S.G. Ojemann. Mock microelectrode recording is undistinguishable from a real time recording in sham surgery controlled clinical trial of new surgical treatment for Parkinson’s disease [Abstract 221]. Movement Disorders 2011;26(Suppl 2): page S73.

PLATFORM PRESENTATIONS and INVITED LECTURES (major)

Klepitskaya O. Tick-Born Encephalitis: what can we learn from it about the West Nile Virus Infection? Grand Rounds, Department of Neurology, University of Colorado Denver, March, 2005 and Department of Neurology and Neurological Sciences, Stanford University, December 2005

Klepitskaya O. Parkinsonism, misinterpreted as status epilepticus. Grand Rounds, Department of Neurology and Neurological Sciences, Stanford University, May 2006; and Grand Rounds, Department of Neurology, University of Colorado Denver, October 2008

Richardson MD, Ojemann SG, Klepitskaya OS. Response of the subthalamic nucleus neurons to vocalization. 1st international symposium “Basal ganglia speech disorders and Deep Brain Stimulation”, July 2007, London, UK

Klepitskaya O. Deep brain stimulation: past, present and future. Grand Rounds, Department of Neurology, University of Colorado Denver, Aurora, CO, April 2007; Colorado Society of Clinical Neurology, Denver, CO, March 2007; and patients’ seminar for Parkinson Association of the Rockies and Deep Brain Stimulation Support Group, Denver, CO, November 2007.

Klepitskaya O. Neurosurgery for Parkinson disease beyond DBS. 22nd Annual conference ‘Neurosurgery in the Rockies”, Beaver Creek, CO, February 2009; Grand Rounds, Department of Neurology University of Colorado Denver, Aurora, CO, August 2009

Klepitskaya O. Update on Neurosurgery for Parkinson’s disease. Colorado Society of Clinical Neurology, Denver, CO, November 2010; and Neurosciences Seminar, Denver, CO, April 2011

Klepitskaya O. Dopamine Dysregulation Syndrome. Grand Rounds, Department of Neurology, University of Colorado Denver, March 2011

CURRENT RESEARCH

• Predictive factors for cognitive outcome after bilateral subthalamic nucleus deep brain stimulation for Parkinson Disease. B. Hoyt, D. Richardson, J. Tanabe, S. Ojemann, T. Oberndorfer, O. Klepitskaya. Role- Primary Investigator

• Three-dimensional computerized model of human basal ganglia for microelectrode recording during deep brain stimulation surgery. Z. Kim, S.G. Ojemann, O.S. Klepitskaya. Role- Primary Investigator

• A multicenter, randomized, double-blind, placebo-controlled, 5-arm, parallel-group trial to assess Rotigotine transdermal system dose response in subjects with advanced-stage Parkinson’s disease. Sponsored by UCB Biosciences, Inc. Role- Sub Investigator

• Phase 2 Safety and Efficacy Study Evaluating Glutamic Acid Decarboxylase Gene Transfer to the Subthalamic Nuclei in Subjects with Advanced Parkinson’s Disease. Sponsored by Neurologix, Inc. Role- Neurophysiologist

• FMRI imaging in patients with Parkinson disease-associated Dopamine dysregulation syndrome. J. Tanabe, O. Klepitskaya. Role- Co- Primary Investigator

• A randomized, double-blind, sham-stimulation controlled study of the application of magnetic fields using the resonator device for the treatment of Parkinson’s disease. Sponsored by Pico-Tesla Magnetic Therapies. Role- Principal Investigator

• DYSPORT™ for Injection AbobotulinumtoxinA Neurotoxin Clinical & Health Economics Outcomes Registry in Cervical Dystonia (ANCHOR–CD). Role- Primary Investigator

COMPLETED RESEARCH

• A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Single Treatment, Sequential Dose-Escalation, Safety, Tolerability and Preliminary Efficacy Study of MYOBLOC ® for the Treatment of Troublesome Sialorrhea in Parkinson’s Disease Patients. Sponsored by Solstice Neurosciences, Inc. Role- Principal Investigator

• Intensive Voice Treatment (LSVT®LOUD) for Parkinson’s disease following Deep Brain Stimulation of the Subthalamic Nucleus. Jennifer Spielman, Leslie Mahler, Angela Halpern, Olga Klepitskaya, Lorraine Ramig. Role- Consultant

• A study to evaluate the safety and ethicacy of IPX066 in advanced Parkinson’s disease. Sponsored by Neurologix Inc. Role- Primary Investigator.

CURRENT REASEARCH SUPPORT

• UCB Biosciences, Inc., Clinical Trial

• Neurologix Inc., Clinical Trial

• Pico-Tesla Magnetic Therapies, LLC, Clinical Trial

• Boedeker Foundation, Parkinson’s Disease Research Gift

• Ipsen, Clinical Trial

OUTREACH AND PATIENT EDUCATION

• Deep Brain Stimulation (DBS) for Parkinson’s disease: Parkinson Association of the Rockies (PAR), October 2007, Denver, CO, 70 attendees.

• Deep Brain Stimulation eases Parkinson’s: Denver Post, May 2008, Denver, CO

• PD 101: Parkinson Association of the Rockies (PAR), October 2008, Denver, CO, 30 attendees

• Her Colors flying: Denver Post, January 2009, Denver, CO

• Treatment of Essential Tremor: International Essential Tremor Foundation, October 2009, Denver CO, 200 attendees.

• Deep Brain Stimulation (DBS) for Movement Disorders: Pueblo Parkinson’s disease Support Group, Pueblo, CO, June 2010, 30 attendees.

• Deep Brain Stimulation (DBS) for Movement Disorders: Grand Junction Patient Symposium, Grand Junction, CO, July 2010, 300 attendees. Was featured on Grand Junction Channel 11 news

• Yoga Used to Treat Parkinson’s Disease: Channel 7 News, August 2010, Denver, CO

• Primary Dystonia Misdiagnosed as Parkinson disease. National VA Parkinson disease consortium meeting in San Francisco. September 2010

• Deep Brain Stimulation (DBS) for Movement Disorders. Achieve Daily Victories Seminar, Basalt, CO, July 23, 2011

PROFESSIONAL MEMBERSHIP

Parkinson Study Group

Movement Disorders Society

American Academy of Neurology

Russian Association of Neurologist and Neurosurgeons

Colorado Society of Clinical Neurology

LICENSES and CERTIFICATIONS

Physician Training License, State of Illinois (2001-2002)

Physician Training License, State of Colorado (2002-2005)

License of Physician and Surgeon, Medical Board of California, 07/2005- 07/2007

Medical License, The Colorado State Board of Medical Examiners, 07/18/2006 - present

Diplomat of American Board of Psychiatry and Neurology, 2008-2018

Medical and Social Interpreter (English- Russian), State of Washington

Medical Doctor-Neurologist, Government of Russian Federation, Far Eastern Office

Medical Doctor-Neurologist of the First Qualification Level, Government of Russian Federation, Far Eastern Office

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