Developmental Origins of Endocrine Dysfunction



FOR WEBSITE-- TO BE USED AS A LINK FOR THE PEDIATRIC DEPARTMENT AND ANY OTHER LAB THAT WISHES IT SO.

Developmental Origins of Endocrine Dysfunction

Overview

The goal of this N.I.H. supported Training Program is to provide high quality research training in one of two major tracks, Basic Science or Clinical Investigation and Epidemiology to pediatricians and basic scientists demonstrating a career commitment to academic pediatric endocrinology and metabolism.

This program is centered in the Division of Pediatric Endocrinology, Ddepartment of Pediatrics, Endocrine Division, but includes faculty from other departments that offer an interdisciplinary research environment for the successful training of young physician-scientist in the specific area of mechanisms playing a role in the impact of early life events on endocrine disorders in post-natal life. The program can also support candidates with a Ph.D. degree seeking further training in endocrinology in a developmental context.

This training grant is a key aspect of the Pediatric Endocrine Subspecialty Training Program.

The Highlights of this Training Program Include:

• Research that uses clinical, cellular/molecular, physiological, and/or behavioral approaches to tackle integrated questions.

• Research Mentors with expertise in a variety of problems and approaches that come from many departments.

• Increasing the breadth of training by including intellectual and technical training from two mentors that represent the basic and clinical links to the chosen project.

• Coursework tailored to the individualized training needs of the trainee.

For more information, contact the Director or Associate Director of the Training Grant.

|Director: |Associate Director: |

|Delia M. Vazquez, M.D. |Vasantha Padmanabham, Ph.D. |

|Associate Professor and Pediatric Endocrine Fellowship Director |Professor and Director of Pediatric Endocrine |

|dmvazq@umich.edu |Research |

| |vasantha@umich.edu |

Pediatric Endocrinology Training Program Faculty: Rank, Research Interest and Role

|Mentor and research track |Rank |Research Interest |

|Christin Carter-Su, PhD |Professor, Molecular and Integrative |Growth/Diabetes: Growth hormone receptor structure |

|Basic Science Track |Physiology |and signal transduction pathways |

|William Herman, MD |Professor, Internal Medicine, Endocrinology|Diabetes: Diabetes, diabetes complications, diabetes|

|Basic Science Track |and Epidemiology, Interim Director, |and pregnancy, diabetes epidemiology, managed care |

|Clinical Investigation Track |Michigan Diabetes Research and Training |and health economics |

| |Center | |

|Jeff Horowitz, PhD |Assistant Professor, Division of |Obesity/Diabetes/Energy Metabolism: regulation of fat|

|Basic Science Track |Kinesiology |and carbohydrate metabolism |

|Josephine Kasa-Vubu, MS, MD |Assistant Professor, Department of |Obesity/Reproduction: Hormonal regulation and |

|Clinical Investigation Track |Pediatrics & Comm Diseases, Pediatric |insulin resistance in adolescent girls. |

| |Endocrine Division | |

|Theresa Lee, PhD |Professor, Psychology & Neuroscience |Behavior/Reproduction/Stress: Regulation of adult |

|Basic Science Track | |sex behavior by prenatal exposure to excess sex |

| | |steroids |

|Ram Menon, MD |Professor, Pediatrics & Comm Diseases & |Growth/Diabetes/Reproduction: Growth hormone action, |

|Basic Science Track |Physiology, Director, Pediatric Endocrine |regulation of gene transcription, and role of growth |

| |Division and Molecular & Integrative |factors in germ cell function. |

| |Physiology | |

|Martin Myers Jr., MD, Ph.D. |Assistant Professor |Obesity/Diabetes: |

|Basic Science Track |Internal Medicine and Physiology |Type 2 diabetes, energy balance, insulin, leptin |

|Vasantha Padmanabhan, PhD |Professor, Pediatrics & Comm Diseases, |Reproduction/Growth: Understanding the fetal origin |

| |Obstetrics and Gynecology, and Molecular & |of pubertal and adult reproductive and metabolic |

|Basic Science Track |Integrative Physiology |disorders and the impact of native steroids and |

|Clinical Investigation Track | |estrogenic environmental pollutants in programming |

| | |such defects. |

|Jessica Schwartz, PhD |Professor, Molecular and Integrative |Growth: Mechanisms for regulation of gene expression|

|Basic Science Track |Physiology; Director, Cellular and |by growth factors |

| |Molecular Biology Training Program | |

|Robert Thompson, PhD |Assistant Professor, Psychiatry and |Obesity/Reproduction: Modulation of processes |

|Basic Science Track |Reproductive Science |leading to successful and unsuccessful reproduction, |

| | |regulation lipid metabolism. |

|Delia M. Vazquez, MD |Associate Professor, Pediatrics & Comm |Stress/Growth/Behavior: Molecular brain mechanisms |

|Basic Science Track |Diseases, Pediatric Endocrinology Division,|underlying long-term consequences of stress in |

|Clinical Investigation Track |and Psychiatry; Research Associate |growing organisms & Consequences of prenatal and |

| |Professor, Center for Human Growth and |postnatal stress in infants and children |

| |Development | |

|Jon Kar Zubieta, MD, PhD |Associate Professor, Departments of |Stress Regulatory Mechanisms |

|Clinical Investigation Track |Psychiatry, Radiology and Mental Health |Examination of neurotransmitter systems and neuronal |

| |Research Institute |nuclei involved in the stress response and emotional |

| | |regulation in humans with PET and fMRI |

The Department of Pediatrics Division of Endocrinology provides an exciting and vigorous research setting for faculty to perform the most advanced research aimed at understanding the pathophysiology of pubertal and adult endocrine, behavioral, growth and reproductive disorders. The Faculty employ a wide array of integrative molecular, cellular, physiologic and clinical approaches to explore fundamental questions relating to growth and differentiation of tissues and the genes and signaling pathways involved in organ function and dysfunction. Both animal and clinical models are effectively employed to gain an understanding of the origin and pathophysiology of pediatric and adult endocrine diseases and develop strategies to prevent or manage diseases. Faculty with both basic and clinical science research interests interact amongst themselves and with various members of the University faculty to provide exciting preclinical, translational and clinical research opportunities. An NIH funded Postdoctoral Research Training Program in Pediatric Endocrinology and Diabetes supported by 10 established investigators from 9 different departments at the University of Michigan facilitates high quality research training for both pediatricians and basic scientists demonstrating a career commitment to academic pediatric endocrinology and metabolism. The individual pediatric endocrinology faculty and their research areas are:

Department’s Web site

Delia M. Vazquez, M.D.

Developmental Origins of Endocrine Dysfunction

A Ppostdoctoral positions are is available to study mechanisms leading to Developmental Origins of Endocrine Dysfunction. The candidate can choose among several targeted areas of pediatric endocrine research – growth, metabolic syndrome, reproduction, and stress and behavior. Each research area is sponsored by one of 10 established investigators from 9 different departments at the University of Michigan who are exploring possible mechanisms of endocrine dysfunction at a cellular and molecular, physiological, behavioral and/or clinical level in a developmental context.

Qualifications: Applicants must hold a Ph.D. in physiology, bioengineering, cell and molecular biology, or a related field from an accredited program. The position is funded by a recent training award from NIH-NIDDK. U.S. citizenship or permanent resident status is necessary due to training grant requirements.

For further information visit our website at -------and contact individual investigators based on your research interest. Please provide a CV, three letters of reference (or contact information), and a detailed cover letter describing research experience, interests, and short and long term career goals.

Post-Doctoral Opportunity Advertisement

Another Version for Web site—which is too wordy….

Developmental Origins of Endocrine Dysfunction

This new postdoctoral research training program in Pediatric Endocrinology and Diabetes at the University of Michigan has two main goals: 1) to provide high quality research training in one of two major tracks, Basic Science or Clinical Investigation and Epidemiology to pediatricians and basic scientists demonstrating a career commitment to academic pediatric endocrinology and metabolism, and 2) to provide an interdisciplinary research environment for the successful training of young physician-scientist in the specific area of mechanisms playing a role in the impact of early life events on endocrine disorders in post-natal life. The Pediatric Endocrinology Training Program (PETP) will provide 2 years of intensive postdoctoral research training for M.D. and Ph.D. trainees in an individualized and closely-mentored research training program designed to best fit each trainee’s skills and interests. For the physician-scientist, this program will be integrated with the ongoing ACGME approved fellowship program to include a one year intensive training in clinical pediatric endocrinology, which will be funded with non-NIH monies. In order to provide outstanding mentorship for the trainees, the PETP will be actively supported by 10 established investigators from 9 different departments at the University of Michigan, all with extensive research and mentoring experience within their respective areas of expertise. Each trainee will be mentored by a clinical/basic dyad of mentors to provide strong footing on hypothesis-driven translational research, centering on developmental origin of endocrine diseases. The trainee will choose among several targeted areas of pediatric endocrine research – growth, metabolic syndrome, reproduction, and stress and behavior. These areas are chosen because of the established strengths of other University of Michigan research programs and participating investigators in the PETP (see PETP Faculty, below). The overarching goal is to foster academic careers that will improve children's health and thereby, the health of the population in the United States.

-----------------------

A Picture Here—someone talking with a trainee while discussion data or at a poster session---Do any of you have a picture like that?

................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download