Pathophysiology of lipid metabolism printout

[Pages:42]10/15/2014

Pathophysiology of lipid metabolism

Kiril Terziyski, MD, PhD Pathophysiology Dept. Medical University - Plovdiv

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Keystones

? Dyslipidemias ? Atherosclerosis ? Obesity

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Why do we need lipids?

? Highest energy value ? Compact storage ? Thermoregulation

? Thermal insulator ? Thermoproduction

(brown adipose tissue)

? Fat-soluble vitamins (A, D, E, K) ? Plastic function (phospholipids)

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Digestion and Absorption

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What may go wrong?

? Insufficient bile in duodenum (cholecystitis, cholelithiasis)

? Insufficient pancreatic lipase in duodenum (pancreatitis)

? Food, rich in Ca2+ and Mg2+ salts ? Stomach hyperacidity (decreased lipase activity) ? Increased intestinal passage ? Hyponatriemia, e.g. Adison's diasease ($-GlyceroP) ? Hypoproteinemia, hypovitaminosis A, B, C (decreased

chylomicron synthesis)

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Further logistics

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How the lungs digest lipids... and more

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The LipoProtein Lipase (LPL) requires ApoC-II as a co-factor

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