Authors: - University of Edinburgh
Article type: ReviewTitle: Recommendations for standardized pathological characterization of residual disease for neoadjuvant clinical trials of breast cancer by the BIG-NABCG collaboration.Authors:V. Bossuyt, Department of Pathology, Yale University, New Haven, Connecticut, United States veerle.bossuyt@yale.eduE. Provenzano, Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom elena.provenzano@addenbrookes.nhs.uk W. F. Symmans, Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States fsymmans@J. C. Boughey, Division of Subspecialty General Surgery, Mayo Clinic, Rochester, Minnesota, United States Boughey.Judy@mayo.edu C. Coles, Oncology Centre, Cambridge University Hospitals National Health Services Foundation Trust, Cambridge, United Kingdom charlotte.coles@addenbrookes.nhs.uk G. Curigliano, Early Drug Development for Innovative Therapies Division, European Institute of Oncology, Milan, Italy giuseppe.curigliano@ieo.it J. M. Dixon, Edinburgh Breast Unit, Western General Hospital, Edinburgh, United Kingdom mike.dixon@ed.ac.uk L. Esserman, Carol Franc Buck Breast Care Center, University of California, San Francisco, California, United States Laura.Esserman@ G. Fastner, Department of Radiotherapy and Radiation Oncology, Landeskrankenhaus, Paracelsus Medical University, Salzburg, Austria g.fastner@salk.atT. Kuehn, Interdisciplinary Breast Center, Department of Gynecology and Obstetrics, Klinikum Esslingen, Essligen, Germany kuehn.thorsten@t-online.de F. Peintinger, Institute of Pathology, Medical University of Graz, Graz, Austria, and Breast Center Salzburg, Paracelsus Medical University, University Hospital Salzburg, Salzburg, Austria florentia.peintinger@medunigraz.at G. von Minckwitz, German Breast Group, Neu-Isenburg, and University Women's Hospital, Frankfurt, Germany gunter.vonminckwitz@germanbreastgroup.de J. White, Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States Julia.White@osumc.edu W. Yang, Department of Diagnostic Radiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States wyang@ S. Badve, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States sbadve@iupui.edu C. Denkert, Institute of Pathology, Charité Hospital, Campus Mitte, Berlin, Germany carsten.denkert@charite.de G. MacGrogan, Department of Biopathology, Institut Bergonié, Bordeaux, France G.MacGrogan@bordeaux.unicancer.fr F. Penault-Llorca, Centre Jean Perrin, Clermont-Ferrand, and Université d'Auvergne, France Frederique.PENAULT-LLORCA@cjp.frG. Viale, Department of Pathology, European Institute of Oncology and University of Milan, Milan, Italy Giuseppe.Viale@ieo.it D. Cameron, Edinburgh Cancer Research UK Centre, The University of Edinburgh, Edinburgh, United Kingdom D.Cameron@ed.ac.uk …of the Breast International Group-North American Breast Cancer Group (BIG-NABCG) collaborationCorresponding author:Dr. Veerle BossuytDepartment of PathologyYale UniversityP.O. Box 208023310 Cedar Street, LH108New Haven, CT 06520-8023 United StatesOffice phone: 1-203-785-5793Fax: 1-203-785-3583Email: veerle.bossuyt@yale.edu ABSTRACT:Background: Neoadjuvant systemic therapy (NAST) provides the unique opportunity to assess response to treatment after months rather than years of follow-up. However, significant variability exists in methods of pathologic assessment of response to NAST, and thus its interpretation for subsequent clinical decisions. Materials and methods: Our international multidisciplinary working group convened by the Breast International Group-North American Breast Cancer Group (BIG-NABCG) collaboration was tasked to recommend practical methods for standardized evaluation of the post-NAST surgical breast cancer specimen for clinical trials, to promote accurate and reliable designation of pathologic complete response (pCR) and meaningful characterization of residual disease. Conclusions: Recommendations include multidisciplinary communication; clinical marking of the tumor site (clips); and radiologic, photographic, or pictorial imaging of the sliced specimen, to map the tissue sections and reconcile macroscopic and microscopic findings. The information required to define pCR (ypT0/is ypN0 or ypT0 yp N0), residual ypT and ypN stage using the current AJCC/UICC system, and the Residual Cancer Burden system were recommended for quantification of residual disease in clinical trials. Key words: breast cancer, neoadjuvant systemic therapy, residual disease, pathologic complete response (pCR), pathologic assessment, response evaluationKey message: Practical methods for standardized pathological characterization of residualdisease for clinical trials of breast cancer include multidisciplinary communication; clinicalmarking of the tumor site; and mapping tissue sections. pCR, the current AJCC/UICC system,and the Residual Cancer Burden system are recommended for quantification of residual disease.INTRODUCTIONResponse to neoadjuvant systemic therapy (NAST) is an excellent indicator of outcome PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db3J0YXphcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+
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ADDIN EN.CITE.DATA [2, 3]. The U.S. Food and Drug Administration (FDA) has recommended pathologic complete response (pCR) as an endpoint for accelerated approval of new agents for neoadjuvant treatment of high-risk early-stage breast cancer, and recently approved pertuzumab based on the increase in pCR rate PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Fc3Nlcm1hbjwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+
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ADDIN EN.CITE.DATA [1]. Therefore, accelerated approval can be based on an improved pCR rate; but improved event-free survival remains the endpoint for full approval. This new regulatory pathway highlights the importance of standardized, reproducible methods of pathology evaluation and reporting for neoadjuvant clinical trials. To use pCR to demonstrate treatment efficacy of novel therapies, we must have a standard definition and approach to pCR assessment. Moreover, with data emerging on regional recurrence risk based on response in the breast and lymph nodes, decisions about subsequent therapy might be based on pathologic assessment of response PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW1vdW5hczwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+
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ADDIN EN.CITE.DATA [8-11]. Careful, systematic evaluation of the post-NAST specimen in the context of clinical and imaging findings is required for accurate diagnosis. Individual pathologists’ experience with NAST specimens and standardization appears to affect results. For example, in a 2004 study PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EaWVyYXM8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [12], using the Chevallier system PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGV2YWxsaWVyPC9BdXRob3I+PFllYXI+MTk5MzwvWWVh
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ADDIN EN.CITE.DATA [13] pCR rates dropped – from 16% and 10% for Arms A and B, respectively, to 8% and 6%– from local to central pathology review. Similarly, in the I-SPY 1 trial, pCR rates fell by almost 10% after training in the Residual Cancer Burden (RCB) system, which requires a standardized approach for pathologic evaluation to map gross and microscopic findings (Laura Esserman, personal communication). A standard approach to post-NAST pathologic assessment of breast cancer would improve comparisons between clinical trials and enable accumulation of more robust evidence in controversial areas of practice such as specimen handling and better serve each patient. METHODSTo build consensus on a more standard characterization of residual disease in breast cancer neoadjuvant trials, the BIG-NABCG collaboration convened an international working group of pathologists, radiologists, surgeons, gynecologists, and medical and radiation oncologists. Members were selected via BIG-NABCG leadership and working group co-chair nomination, as well as referred by sites involved in neoadjuvant trials. The working group reviewed SOPs for pathologic assessment from 28 major NAST breast cancer trials and 25 trial sites, finding a variety of approaches (Supplement 1). Moreover, sites submitting SOPs noted a need for a standard. The working group developed practical recommendations for the post-NAST pathologic assessment of breast cancer in neoadjuvant clinical trials. Detailed recommendations for pathologists including more detailed discussion of their evidence base when available or of their rationale are published in our pathology-focused paper ADDIN EN.CITE <EndNote><Cite><Author>Provenzano</Author><Year>2015</Year><RecNum>188</RecNum><record><rec-number>188</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">188</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Provenzano, E.</author><author>Bossuyt, V.</author><author>Viale, G.</author><author>Cameron, D.</author><author>Badve, S.</author><author>Denkert, C.</author><author>MacGrogan, G.</author><author>Penault-Llorca, F.</author><author>Boughey, J. C.</author><author>Curigliano, G.</author><author>Dixon, J. Michael</author><author>Esserman, L. J.</author><author>Fastner, G.</author><author>Kuehn, T.</author><author>Peintinger, F.</author><author>von Minckwitz, G.</author><author>White, J.</author><author>Yang, W.</author><author>Symmans, W. F.</author></authors></contributors><titles><title>Standardization of pathologic evaluation and reporting of post-neoadjuvant specimens in clinical trials of breast cancer: Recommendations from an international working group</title><secondary-title>Modern Pathol</secondary-title></titles><periodical><full-title>Modern Pathol</full-title></periodical><volume>(In press)</volume><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[14]. This paper summarizes the recommendations for pathologic assessment for a multidisciplinary audience, addresses the prerequisites for accurate pathologic assessment and explains how a standardized approach would benefit the entire medical team. The majority of available evidence pertains to neoadjuvant chemotherapy. However we did not identify existing data or conceptual reasons to limit this standardization effort to neoadjuvant chemotherapy only. When evidence was found lacking recommendations represent a consensus opinion of a pragmatic approach based on personal experience and our review of the SOP’s of major NAST breast cancer trials. RECOMMENDATIONSWhile the basic principles are similar in neoadjuvant and adjuvant situations, NAST specimens are generally more challenging. Therefore, multi-disciplinary communication is essential before, during, and after NAST. The recommendations are for clinical trials; they can optionally be incorporated into routine practice because, in our opinion, standardization is most effective when uniformly applied. Initial diagnosisA percutaneous image-guided core needle biopsy (CNB) is strongly recommended. The CNB must be adequate for an unequivocal diagnosis of invasion. Pre-treatment tumor size (T stage) is based on imaging and physical examination. 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ADDIN EN.CITE.DATA [16]. If, after the first or subsequent cycle(s) of chemotherapy, the decrease in tumor volume suggests a possible complete response and a clip was not placed previously, it is imperative to place a clip, even if mastectomy is planned. After completion of NAST it may be difficult to identify the correct area in the breast or to ensure that the appropriate area was excised, if no clip was placed.Evaluation of the axilla pre-NASTSystemic or local treatment decisions may be based on axillary status at presentation (pre-NAST). Pre-NAST sentinel lymph node biopsy (SLNB) is not recommended because assessment of nodal response in the axilla, a very important determinant of survival post-NAST, is unreliable after excision of a positive node. Furthermore, this invalidates the RCB score and the ypN stage, and potentially compromises comparisons of pCR results across different studies. This position should be balanced against the accuracy of SLNB post-NAST ADDIN EN.CITE <EndNote><Cite><Author>Kuehn</Author><Year>2013</Year><RecNum>130</RecNum><record><rec-number>130</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">130</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kuehn, T.</author><author>Bauerfeind, I.</author><author>Fehm, T.</author><author>Fleige, B.</author><author>Hausschild, M.</author><author>Helms, G.</author><author>Lebeau, A.</author><author>Liedtke, C.</author><author>Minckwitz, Gv</author><author>Nekljudova, V.</author><author>Schmatloch, S.</author><author>Schrenk, P.</author><author>Staebler, A.</author><author>Untch, M.</author></authors></contributors><auth-address>Interdisciplinary Breast Centre, Department of Gynaecology and Obstetrics, Klinikum Esslingen, Esslingen, Germany. Electronic address: t.kuehn@klinikum-esslingen.de.</auth-address><titles><title>Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study</title><secondary-title>Lancet Oncol</secondary-title><alt-title>The lancet oncology</alt-title></titles><periodical><full-title>Lancet Oncol</full-title><abbr-1>The lancet oncology</abbr-1></periodical><alt-periodical><full-title>Lancet Oncol</full-title><abbr-1>The lancet oncology</abbr-1></alt-periodical><pages>609-18</pages><volume>14</volume><number>7</number><dates><year>2013</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1474-5488 (Electronic)
1470-2045 (Linking)</isbn><accession-num>23683750</accession-num><urls><related-urls><url> </url></related-urls></urls><language>eng</language></record></Cite></EndNote>[17]. Post-NAST SLNB is strongly recommended.So, to obtain maximum information about the axillary status pre-NAST for systemic or local treatment decisions, routine ultrasound of the regional nodal basins is strongly encouraged. Diagnosis of clinically or radiologically abnormal lymph nodes by fine needle aspiration (FNA) or CNB ADDIN EN.CITE <EndNote><Cite><Author>Houssami</Author><Year>2011</Year><RecNum>159</RecNum><record><rec-number>159</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">159</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Houssami, N.</author><author>Ciatto, S.</author><author>Turner, R. M.</author><author>Cody, H. S., 3rd</author><author>Macaskill, P.</author></authors></contributors><auth-address>Screening and Test Evaluation Program, School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia. nehmath@med.usyd.edu.au</auth-address><titles><title>Preoperative ultrasound-guided needle biopsy of axillary nodes in invasive breast cancer: meta-analysis of its accuracy and utility in staging the axilla</title><secondary-title>Ann Surg</secondary-title><alt-title>Annals of surgery</alt-title></titles><periodical><full-title>Ann Surg</full-title><abbr-1>Annals of surgery</abbr-1></periodical><alt-periodical><full-title>Ann Surg</full-title><abbr-1>Annals of surgery</abbr-1></alt-periodical><pages>243-51</pages><volume>254</volume><number>2</number><keywords><keyword>Axilla</keyword><keyword>Biopsy, Needle/*methods</keyword><keyword>Breast Neoplasms/*pathology</keyword><keyword>Carcinoma, Ductal, Breast/*pathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lymph Nodes/*pathology</keyword><keyword>Lymphatic Metastasis/*pathology</keyword><keyword>Sensitivity and Specificity</keyword><keyword>Tumor Burden</keyword><keyword>*Ultrasonography, Interventional</keyword></keywords><dates><year>2011</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1528-1140 (Electronic)
0003-4932 (Linking)</isbn><accession-num>21597359</accession-num><urls><related-urls><url> </url></related-urls></urls><language>eng</language></record></Cite></EndNote>[18] is strongly recommended prior to NAST. Clip placement into the biopsied node may improve the accuracy of post-NAST SLNB. If in clinically node-negative patients it is felt that pre-therapeutic sentinel lymph node status will determine systemic or local treatment SLNB pre-NAST is an option.Preoperative staging and surgery post-NASTPre-operative imaging should be appropriate for the clinical stage at presentation, and is important to document the clinical extent of residual disease. Surgical resection volume is based on pre-operative imaging. All detectable residual disease should be removed by the surgery with clear margins PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWphbjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [19-21]. In cases of complete radiologic response, the center of the tumor bed should be removed, including any radiologic clips. Pre- or intraoperative localization techniques and orientation of the specimen by the surgeon are imperative. In addition, marking the tumor bed with clips at the time of surgery is encouraged ADDIN EN.CITE <EndNote><Cite><Author>Coles</Author><Year>2009</Year><RecNum>125</RecNum><record><rec-number>125</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">125</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Coles, C. E.</author><author>Wilson, C. B.</author><author>Cumming, J.</author><author>Benson, J. R.</author><author>Forouhi, P.</author><author>Wilkinson, J. S.</author><author>Jena, R.</author><author>Wishart, G. C.</author></authors></contributors><auth-address>Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.</auth-address><titles><title>Titanium clip placement to allow accurate tumour bed localisation following breast conserving surgery: audit on behalf of the IMPORT Trial Management Group</title><secondary-title>Eur J Surg Oncol</secondary-title></titles><periodical><full-title>Eur J Surg Oncol</full-title></periodical><pages>578-82</pages><volume>35</volume><number>6</number><keywords><keyword>Biocompatible Materials</keyword><keyword>Breast Neoplasms/*radiotherapy/*surgery</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Mastectomy, Segmental/*instrumentation</keyword><keyword>Medical Audit</keyword><keyword>Neoplasm Recurrence, Local/*diagnosis</keyword><keyword>Radiotherapy Planning, Computer-Assisted/*instrumentation</keyword><keyword>*Surgical Instruments</keyword><keyword>Titanium</keyword></keywords><dates><year>2009</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1532-2157 (Electronic)
0748-7983 (Linking)</isbn><accession-num>18938055</accession-num><urls><related-urls><url> </url></related-urls></urls><language>eng</language></record></Cite></EndNote>[22].Essential information accompanying the post-NAST surgical specimenTable 1 lists the clinical information that should be available to the pathologist for optimal evaluation of the post-NAST specimen. The Supplemental Materials include a suggested template requisition form to send with the post-NAST specimen (Supplement 2). At an absolute minimum, the specimen must be clearly marked as post-NAST and the pre-NAST location and size of the tumor must be indicated.Evaluation of the post-NAST surgical specimenPathologic evaluation of the post-NAST specimen must ensure that the surgery is adequate (identify tumor bed, assess margins), evaluate prognostic factors (document pCR or confirm size/extent of residual tumor, and allow microscopic estimate of residual tumor cellularity), and permit collection of research samples. Recommended data in the pathology reportTable 2 summarizes the recommended elements not always routinely included in the adjuvant setting but recommended in the pathology report of the post-NAST specimen. We strongly recommend that the manner of specimen processing and reporting allow for tumor staging and calculation of the RCB score PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48UmVjTnVtPjMy
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ADDIN EN.CITE.DATA [23, 24], as described below. In addition, we also encourage reporting using another system (e.g., Chevallier, Sataloff) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGV2YWxsaWVyPC9BdXRob3I+PFllYXI+MTk5MzwvWWVh
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ADDIN EN.CITE.DATA [10, 26] are likely to be used, we recommend reporting the cellularity of the pre-NAST CNB. The U.S. National Cancer Institute BOLD Task force has also recommended standardized data elements for collection in preoperative breast cancer clinical trials ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>187</RecNum><record><rec-number>187</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">187</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>National Cancer Institute. Breast Cancer Steering Committee. Investigator Resources. NCI BOLD Task Force CDEs. ;[27]. Extent of samplingAccurate, reproducible documentation of pathologic response to NAST requires adequate sampling of the correct area of the breast. Overly exhaustive sampling and histologic evaluation of the entire tumor bed are not required and not as efficient or informative as informed mapping of the specimen. Clinical and imaging information, as well as marking of the tumor site, are critical in the selection of the areas to sample (Table 1). Furthermore, images of the sliced resection specimen (with a scale for measurement) are useful as maps on which to annotate the tissue sections that correspond to the different slides. This greatly helps the pathologist to reconstruct the extent and location of disease after reviewing the slides under the microscope. This technique is critical for more standardized and accurate staging of the residual tumor and calculation of RCB, and generally requires fewer tissue blocks to be processed, less time, and less expense. Figure 1 summarizes possible patterns of tumor response in the breast and associated sampling problems affecting determination of extent and cellularity of residual disease. Because of these issues, we recommend systematic sampling with mapping of the specimen as described below and further detailed in our pathology-focused paper ADDIN EN.CITE <EndNote><Cite><Author>Provenzano</Author><Year>2015</Year><RecNum>188</RecNum><record><rec-number>188</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">188</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Provenzano, E.</author><author>Bossuyt, V.</author><author>Viale, G.</author><author>Cameron, D.</author><author>Badve, S.</author><author>Denkert, C.</author><author>MacGrogan, G.</author><author>Penault-Llorca, F.</author><author>Boughey, J. C.</author><author>Curigliano, G.</author><author>Dixon, J. Michael</author><author>Esserman, L. J.</author><author>Fastner, G.</author><author>Kuehn, T.</author><author>Peintinger, F.</author><author>von Minckwitz, G.</author><author>White, J.</author><author>Yang, W.</author><author>Symmans, W. F.</author></authors></contributors><titles><title>Standardization of pathologic evaluation and reporting of post-neoadjuvant specimens in clinical trials of breast cancer: Recommendations from an international working group</title><secondary-title>Modern Pathol</secondary-title></titles><periodical><full-title>Modern Pathol</full-title></periodical><volume>(In press)</volume><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[14]. This pragmatic approach is a consensus based on personal experience and our review of the SOP’s of major NAST breast cancer trials.If the resection specimen is small (e.g., <30g), it would be reasonable to process all of the excised tissue for microscopic evaluation. However, description or preferably an image of the sliced specimen should still be used to map the location of each tissue section. Using the techniques described below it is often still possible to collect research rmation on pre-NAST tumor size and location is critical. Systematic sampling should include macroscopically visible tumor/ tumor bed and immediately adjacent tissue, to represent the area suspected of involvement by carcinoma before treatment (area of interest, AI). Extent of sampling is thus determined by the pre-treatment size in addition to macroscopic pathologic evaluation, supplemented by any specimen radiography. Sometimes, additional sampling may be needed after reviewing the initial sections under the microscope.Accurate description or diagrams (maps, ideally drawn on digital photographs or radiographs) must be used to reconstruct the specimen after microscopic evaluation for accurate measurements of extent of residual disease and estimates of cellularity, as well as to ensure adequacy of sampling (Figure 2). A cutoff of an entire cross-section of the area of interest as described above (AI) per 1 cm of pre-treatment size or, for very large tumors, five representative blocks of a cross-section of AI per 1-2 cm of pre-treatment size, with a maximum of about 25 blocks of AI, should be sufficient to confidently document pCR in most cases, provided a tumor bed or clip is identified.Collection of tissue samples for research purposesWe generally recommend that dedicated research samples (to be frozen or otherwise prepared in a non-clinical manner) only be collected if there is grossly obvious residual invasive cancer. Such sites are the most likely to contain diagnostically expendable tumor tissue of sufficient cellularity for research use. One can thin a section and submit the trim for research. Another practical approach is to obtain small cylinders of tissue for research from the slices with a punch biopsy tool. Where the research tissue was collected can so be seen on the histology slides. 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ADDIN EN.CITE.DATA [15].Tumor grade and typeHistologic tumor type can be more difficult to ascertain after NAST. NAST can cause nuclear hyperchromasia and pleomorphism and can alter the mitotic rate ADDIN EN.CITE <EndNote><Cite><Author>Pinder</Author><Year>2007</Year><RecNum>25</RecNum><record><rec-number>25</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">25</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pinder, S. E.</author><author>Provenzano, E.</author><author>Earl, H.</author><author>Ellis, I. O.</author></authors></contributors><auth-address>Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. sep43@cam.ac.uk</auth-address><titles><title>Laboratory handling and histology reporting of breast specimens from patients who have received neoadjuvant chemotherapy</title><secondary-title>Histopathology</secondary-title><alt-title>Histopathology</alt-title></titles><periodical><full-title>Histopathology</full-title><abbr-1>Histopathology</abbr-1></periodical><alt-periodical><full-title>Histopathology</full-title><abbr-1>Histopathology</abbr-1></alt-periodical><pages>409-17</pages><volume>50</volume><number>4</number><keywords><keyword>Antineoplastic Combined Chemotherapy Protocols/therapeutic use</keyword><keyword>Breast Neoplasms/diagnosis/*drug therapy/pathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lymph Nodes/pathology</keyword><keyword>Lymphatic Metastasis</keyword><keyword>Neoadjuvant Therapy</keyword><keyword>Practice Guidelines as Topic</keyword><keyword>Prognosis</keyword><keyword>Research Design</keyword><keyword>Specimen Handling</keyword></keywords><dates><year>2007</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0309-0167 (Print)
0309-0167 (Linking)</isbn><accession-num>17448015</accession-num><urls><related-urls><url> </url></related-urls></urls><language>eng</language></record></Cite></EndNote>[10]; however, histologic grade should be compared to the pre-treatment biopsy before assuming that findings are treatment-related.Tumor extent and cellularityTumor size/extent is often difficult to assess after NAST. Residual tumor is often softer and more difficult to see grossly. The residual carcinoma may be present as small foci scattered over a (ill defined) tumor bed ADDIN EN.CITE <EndNote><Cite><Author>Mukhtar</Author><Year>2013</Year><RecNum>144</RecNum><record><rec-number>144</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">144</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mukhtar, R. A.</author><author>Yau, C.</author><author>Rosen, M.</author><author>Tandon, V. J.</author><author>Hylton, N.</author><author>Esserman, L. J.</author></authors></contributors><auth-address>University of California, San Francisco, San Francisco, CA, USA.</auth-address><titles><title>Clinically Meaningful Tumor Reduction Rates Vary by Prechemotherapy MRI Phenotype and Tumor Subtype in the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657)</title><secondary-title>Ann Surg Oncol</secondary-title><alt-title>Annals of surgical oncology</alt-title></titles><periodical><full-title>Ann Surg Oncol</full-title><abbr-1>Annals of surgical oncology</abbr-1></periodical><alt-periodical><full-title>Ann Surg Oncol</full-title><abbr-1>Annals of surgical oncology</abbr-1></alt-periodical><pages>3823–30</pages><volume>20</volume><dates><year>2013</year><pub-dates><date>Jun 19</date></pub-dates></dates><isbn>1534-4681 (Electronic)
1068-9265 (Linking)</isbn><accession-num>23780381</accession-num><urls><related-urls><url> </url></related-urls></urls><language>Eng</language></record></Cite></EndNote>[28].The most recent (7th edition) ADDIN EN.CITE <EndNote><Cite><Author>Edge</Author><Year>2009</Year><RecNum>47</RecNum><record><rec-number>47</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">47</key></foreign-keys><ref-type name="Edited Book">28</ref-type><contributors><authors><author>Edge, S. B. </author><author>Byrd, D. R. </author><author>Compton, C. C. </author><author>Fritz, A. G. </author><author>Greene, F. L. </author><author>Trotti, A. </author></authors></contributors><titles><title>American Joint Committee on Cancer (AJCC) Cancer Staging Manual, 7th edition</title></titles><dates><year>2009</year></dates><publisher>Springer</publisher><urls></urls></record></Cite></EndNote>[29] American Joint Committee on Cancer (AJCC)/ Union for International Cancer Control (UICC) recommendation to measure the largest contiguous focus excluding areas with intervening fibrosis may result in a systematic artificial down-staging of tumors with a scattered response pattern if scattered tumor nests were part of a single tumor mass before treatment. There are currently no data linking this tumor measurement to survival outcome. Note that prior publications concerning prognosis of yp-TNM staging used the earlier (6th edition) ADDIN EN.CITE <EndNote><Cite><Author>Greene</Author><Year>2002</Year><RecNum>161</RecNum><record><rec-number>161</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">161</key></foreign-keys><ref-type name="Edited Book">28</ref-type><contributors><authors><author>Greene, F. L.</author><author>Page, D. L.</author><author>Fleming, I. D.</author><author>Fritz, A.</author><author>Balch, C. M.</author><author>Haller, D. G.</author><author>Morrow, M. (eds). </author></authors></contributors><titles><title>American Joint Committee on Cancer (AJCC) Cancer Staging Manual, 6th edition </title></titles><dates><year>2002</year></dates><publisher>Springer-Verlag</publisher><urls></urls></record></Cite></EndNote>[30] AJCC staging system, which considered the largest extent of residual cancer allowing for intervening fibrosis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXJleTwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [31, 32]. In addition, multifocal tumors should be separated by abundant normal breast or adipose tissue and should be measured independently and documented. In this situation, dimensions from the largest tumor deposit should be used for AJCC staging, with “m” indicating the presence of multiple tumors.Generally, tumor cellularity decreases with tumor size; but this is quite variable and so their combined results are more informative PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWphbjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [19]. In some cases, tumor size may not decrease, but overall cellularity may be markedly reduced (Figure 1). Comparison of pre- and post-treatment cellularity is the key element of several systems for classifying residual disease, including the Miller-Payne and Pinder systems PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PZ3N0b248L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [10, 26]. These systems, however, do not state how to deal with heterogeneity, and it can be tempting to only assess the most cellular areas of the tumor. Even pre-treatment cellularity is often heterogeneous, with pre-treatment CNB only partly representing the tumor. Similarly, changes in tumor cellularity induced by NAST are commonly heterogeneous (Figure 1). Systematic sampling as described above is therefore needed to accurately assess cellularity.Although it ignores pre-treatment cellularity, the RCB system offers several advantages in addressing this heterogeneity. The RCB system standardizes sampling of specimens and interprets the average invasive cancer cellularity (by area) across the entire residual tumor bed. The residual tumor bed area is initially determined from the macroscopic evaluation combined with any specimen radiography, and revised after the corresponding tissue sections from that area have been studied under the microscope. Calibrating the observer’s eyes to the online cellularity standard provided on the RCB website can be helpful ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>32</RecNum><record><rec-number>32</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">32</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors></contributors><titles><title>Residual Cancer Burden calculator and associated documents [Guide for Measuring Cancer Cellularity, Examples of Gross & Microscopic Evaluation, Pathology Protocol for Macroscopic and Microscopic Assessment of RCB] Anderson Cancer Center, Houston, TX</publisher><urls><related-urls><url>;[23]. The images in the publication for the Miller-Payne score are also helpful PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PZ3N0b248L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [26].Assessment of RCB is quite reproducible ADDIN EN.CITE <EndNote><Cite><Author>Peintinger</Author><Year>2015</Year><RecNum>189</RecNum><record><rec-number>189</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">189</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Peintinger, F.</author><author>Sinn, B.</author><author>Hatzis, C. </author><author>Albarracin, C.T. </author><author>Downs-Kelly, E. </author><author>Morkowski, J.</author><author>Rebekah Gould </author><author>Symmans, W. F.</author></authors></contributors><titles><title>Reproducibility of Residual Cancer Burden For Prognostic Assessment of Breast Cancer After Neoadjuvant Chemotherapy</title><secondary-title>Modern Pathol</secondary-title></titles><periodical><full-title>Modern Pathol</full-title></periodical><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[33]. This system helps to standardize gross and microscopic methods, and is more efficiently utilized in a prospective manner, rather than by retrospective review. As a first step, we advocate reporting the two-dimensional size of the largest distance between residual tumor cell nests in a cross-section of the entire area involved by residual tumor. The relevant sections should be recorded in the pathology report. Thus, the benefit of uniform sampling is achieved and RCB assessment, including average cellularity of the tumor bed area, can be performed upon central review. A simple qualitative assessment of cellularity can be performed at the peripheral site.MarginsAssessment of margins may be less reliable post-NAST in cases with scattered response. Tumor bed extending to the margins should be documented.Evaluation of the axilla post-NASTPost-NAST lymph node status is an important determinant of survival, regardless of response within the breast PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW1vdW5hczwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+
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ADDIN EN.CITE.DATA [17, 41].Pathologic evaluation is the same as for non-NAST specimens, although lymph nodes may be more difficult to identify grossly. All surgically removed lymph nodes should be entirely submitted for histologic evaluation, sectioned at 2 mm intervals. Additional levels and IHC are not routinely required. The number of positive lymph nodes, size of the largest metastasis, and presence of micrometastasis and isolated tumor cells (ITCs) are predictors of worse survival and should be recorded PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbGF1YmVyLURlTW9yZTwvQXV0aG9yPjxZZWFyPjIwMDY8
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ADDIN EN.CITE.DATA [45]; however, this can be difficult to discern. Small fibrous scars suggestive of prior lymph node involvement or treatment effect can also be seen in patients without treatment ADDIN EN.CITE <EndNote><Cite><Author>Donnelly</Author><Year>2001</Year><RecNum>61</RecNum><record><rec-number>61</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">61</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Donnelly, J.</author><author>Parham, D. M.</author><author>Hickish, T.</author><author>Chan, H. Y.</author><author>Skene, A. I.</author></authors></contributors><auth-address>Royal Bournemouth Hospital Breast Unit, Bournemouth, UK. jill.donnelly@</auth-address><titles><title>Axillary lymph node scarring and the association with tumour response following neoadjuvant chemoendocrine therapy for breast cancer</title><secondary-title>Breast</secondary-title><alt-title>Breast (Edinburgh, Scotland)</alt-title></titles><periodical><full-title>Breast</full-title><abbr-1>Breast (Edinburgh, Scotland)</abbr-1></periodical><alt-periodical><full-title>Breast</full-title><abbr-1>Breast (Edinburgh, Scotland)</abbr-1></alt-periodical><pages>61-6</pages><volume>10</volume><number>1</number><dates><year>2001</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0960-9776 (Print)
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ADDIN EN.CITE.DATA [51]. The reported rates of discordant results should be interpreted in the context of the expected discordance rate from technical variability in repeated measurements (about 10% for a 95% accurate test.)?In current practice, the choice of adjuvant therapy is dictated by the results at primary diagnosis. However, patients with residual disease that originally had negative receptor status can be re-tested to re-evaluate for eligibility for a targeted adjuvant treatment. Re-assessment of hormone receptor (HR) and HER2 in all cases with residual disease can be considered in clinical trials to gather high-quality data to clarify these issues. Otherwise we recommend repeat testing only in circumstances where the clinical course or pathologic findings suggest repeat testing may yield a different result that would change treatment. If pre- and post-NAST results are discrepant, retesting of the pre-treatment biopsy should also be considered.?Ki67 expression correlates with long-term outcome, whether natural prognosis or after endocrine PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FbGxpczwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [53, 54]. Despite concerns about the analytical reproducibility of Ki67 measurements PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Eb3dzZXR0PC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48
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ADDIN EN.CITE.DATA [52, 58].Pathologic complete response (pCR)To date, a variety of definitions of pCR have been used in neoadjuvant clinical trials in breast cancer, impeding cross-trial interpretation of data ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1"><Year>2014</Year><RecNum>29</RecNum><record><rec-number>29</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">29</key></foreign-keys><ref-type name="Government Document">46</ref-type><contributors></contributors><titles><title>U.S. Food and Drug Administration. Guidance for Industry: Pathological Complete Response in Neoadjuvant Treatment of High-Risk Early-Stage Breast Cancer: Use as an Endpoint to Support Accelerated Approval. October 2014. </title></titles><pages> app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">188</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Provenzano, E.</author><author>Bossuyt, V.</author><author>Viale, G.</author><author>Cameron, D.</author><author>Badve, S.</author><author>Denkert, C.</author><author>MacGrogan, G.</author><author>Penault-Llorca, F.</author><author>Boughey, J. C.</author><author>Curigliano, G.</author><author>Dixon, J. Michael</author><author>Esserman, L. J.</author><author>Fastner, G.</author><author>Kuehn, T.</author><author>Peintinger, F.</author><author>von Minckwitz, G.</author><author>White, J.</author><author>Yang, W.</author><author>Symmans, W. F.</author></authors></contributors><titles><title>Standardization of pathologic evaluation and reporting of post-neoadjuvant specimens in clinical trials of breast cancer: Recommendations from an international working group</title><secondary-title>Modern Pathol</secondary-title></titles><periodical><full-title>Modern Pathol</full-title></periodical><volume>(In press)</volume><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[5, 14]. In its guidance on the potential use of pCR to accelerate drug approval, the U.S. FDA defines pCR as either ypT0/isypN0 or ypT0ypN0 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db3J0YXphcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+
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ADDIN EN.CITE.DATA [1, 7, 34-40]. Whereas it is clear that patients with residual carcinoma in the lymph nodes only (ypT0/is ypN+) have a considerably inferior prognosis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db3J0YXphcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+
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ADDIN EN.CITE.DATA [59]. Future studies should prospectively select either ypT0/is ypN0 or ypT0 ypN0 as a primary endpoint and state which definition is used; we would recommend also reporting the other as a secondary/exploratory endpoint. Pathologists should report DCIS, remembering to note if it is absent, so the data needed for further examination of outcomes associated with these two pCR definitions can be gathered.Table 3 summarizes our recommendations for the assessment of pCR. Immunohistochemistry (IHC) is not required but may be helpful to visualize tumor cells when hematoxylin and eosin (H&E) staining is inconclusive, or as part of an SOP for SLN evaluation. If residual tumor cells are present, they should be considered in the same manner whether identified on H&E or IHC. The companion pathology paper discusses occasionally controversial elements in detail ADDIN EN.CITE <EndNote><Cite><Author>Provenzano</Author><Year>2015</Year><RecNum>188</RecNum><record><rec-number>188</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">188</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Provenzano, E.</author><author>Bossuyt, V.</author><author>Viale, G.</author><author>Cameron, D.</author><author>Badve, S.</author><author>Denkert, C.</author><author>MacGrogan, G.</author><author>Penault-Llorca, F.</author><author>Boughey, J. C.</author><author>Curigliano, G.</author><author>Dixon, J. Michael</author><author>Esserman, L. J.</author><author>Fastner, G.</author><author>Kuehn, T.</author><author>Peintinger, F.</author><author>von Minckwitz, G.</author><author>White, J.</author><author>Yang, W.</author><author>Symmans, W. F.</author></authors></contributors><titles><title>Standardization of pathologic evaluation and reporting of post-neoadjuvant specimens in clinical trials of breast cancer: Recommendations from an international working group</title><secondary-title>Modern Pathol</secondary-title></titles><periodical><full-title>Modern Pathol</full-title></periodical><volume>(In press)</volume><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[14]. Residual diseaseUsing pCR as the only indicator of response to NAST underestimates the clinical benefit a patient receives in terms of event-free survival. Simulations show that measures of residual disease can improve the power of neoadjuvant clinical trials and will improve estimates of survival benefits ADDIN EN.CITE <EndNote><Cite><Author>Hatzis</Author><Year>2013</Year><RecNum>178</RecNum><record><rec-number>178</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">178</key></foreign-keys><ref-type name="Conference Proceedings">10</ref-type><contributors><authors><author>Hatzis, C.</author><author>Gould, R.E.</author><author>Zhang, Y.</author><author>Abu-Khalaf, M.</author><author>Chung, G.</author><author>Sanft, T.</author><author>Hofstatter, E.</author><author>DiGiovanna, M.</author><author>Shi, W.</author><author>Chagpar, A.</author><author>Symmans, W.F.</author><author>Pusztai L.</author></authors></contributors><titles><title>Predicting improvements in survival based on improvements in pathologic response rate to neoadjuvant chemotherapy in different breast cancer subtypes (abstract P6-06-37)</title><secondary-title>San Antonio Breast Cancer Symposium</secondary-title></titles><dates><year>2013</year></dates><pub-location>San Antonio, Texas</pub-location><urls></urls></record></Cite></EndNote>[60]. There is great interest to gain further prognostic information from the extent of residual disease through evaluation of, e.g., yp-Stage, RCB, and PEPI, and also from the biology of residual disease, e.g., using Ki67 and multi-gene assays in residual disease PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TeW1tYW5zPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48
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ADDIN EN.CITE.DATA [24, 52, 58, 61, 62]. Different classification systems can yield different estimates of future risk ADDIN EN.CITE <EndNote><Cite><Author>Corben</Author><Year>2013</Year><RecNum>143</RecNum><record><rec-number>143</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">143</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Corben, A. D.</author><author>Abi-Raad, R.</author><author>Popa, I.</author><author>Teo, C. H.</author><author>Macklin, E. A.</author><author>Koerner, F. C.</author><author>Taghian, A. G.</author><author>Brachtel, E. F.</author></authors></contributors><auth-address>From the Departments of Pathology (Drs Corben, Popa, Teo, Koerner, and Brachtel, Radiation Oncology (Drs Abi-Raad and Taghian), and Biostatistics (Dr Macklin), Massachusetts General Hospital and Harvard Medical School, Boston. Dr Corben is now with Memorial Sloan-Kettering Cancer Center, New York, New York. Dr Abi-Raad is now with Yale University, New Haven, Connecticut. Dr Teo is now with Tan Tock Sen Hospital, Singapore.</auth-address><titles><title>Pathologic Response and Long-Term Follow-up in Breast Cancer Patients Treated With Neoadjuvant Chemotherapy: A Comparison Between Classifications and Their Practical Application</title><secondary-title>Arch Pathol Lab Med</secondary-title><alt-title>Archives of pathology & laboratory medicine</alt-title></titles><periodical><full-title>Arch Pathol Lab Med</full-title><abbr-1>Archives of pathology & laboratory medicine</abbr-1></periodical><alt-periodical><full-title>Arch Pathol Lab Med</full-title><abbr-1>Archives of pathology & laboratory medicine</abbr-1></alt-periodical><pages>1074-82</pages><volume>137</volume><number>8</number><dates><year>2013</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1543-2165 (Electronic)
0003-9985 (Linking)</isbn><accession-num>23899063</accession-num><urls><related-urls><url> </url></related-urls></urls><language>eng</language></record></Cite></EndNote>[40]. Systems that combine clinical, pathologic, and biomarker information pre- and post-NAST, thus incorporating information about pre-treatment tumor burden, residual disease, and biology, will likely be the most useful ADDIN EN.CITE <EndNote><Cite><Author>Symmans</Author><Year>2013</Year><RecNum>171</RecNum><record><rec-number>171</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">171</key></foreign-keys><ref-type name="Conference Proceedings">10</ref-type><contributors><authors><author>Symmans, W.F.</author><author>Wei, C.</author><author>Gould, R.</author><author>Zhang, Y.</author><author>Hunt, K.K.</author><author>Buchholz, T.A.</author><author>Valero, V.</author><author>Hortobagyi, G.N.</author><author>Pusztai, L.</author><author>Hatzis, C.</author></authors></contributors><titles><title>Long-term prognostic value of residual cancer burden (RCB) classification following neoadjuvant chemotherapy [abstract S6-02]</title><secondary-title>San Antonio Breast Cancer Symposium</secondary-title></titles><dates><year>2013</year><pub-dates><date>10-14 Dec 2013</date></pub-dates></dates><pub-location>San Antonio, TX, USA</pub-location><urls></urls></record></Cite></EndNote>[61]. For example, the clinical-pathologic stage-estrogen/grade (CPS-EG) combines pathologic stage post-NAST with clinical stage pre-NAST, nuclear grade, and ER status, and has been independently validated in small studies to identify patients with residual disease post-NAST who have a high risk of relapse ADDIN EN.CITE <EndNote><Cite><Author>Mittendorf</Author><Year>2011</Year><RecNum>158</RecNum><record><rec-number>158</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">158</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mittendorf, E. A.</author><author>Jeruss, J. S.</author><author>Tucker, S. L.</author><author>Kolli, A.</author><author>Newman, L. A.</author><author>Gonzalez-Angulo, A. M.</author><author>Buchholz, T. A.</author><author>Sahin, A. A.</author><author>Cormier, J. N.</author><author>Buzdar, A. U.</author><author>Hortobagyi, G. N.</author><author>Hunt, K. K.</author></authors></contributors><auth-address>University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.</auth-address><titles><title>Validation of a novel staging system for disease-specific survival in patients with breast cancer treated with neoadjuvant chemotherapy</title><secondary-title>J Clin Oncol</secondary-title></titles><periodical><full-title>J Clin Oncol</full-title></periodical><pages>1956-62</pages><volume>29</volume><number>15</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Antineoplastic Agents/therapeutic use</keyword><keyword>Breast Neoplasms/drug therapy/mortality/*pathology</keyword><keyword>Chemotherapy, Adjuvant</keyword><keyword>Disease-Free Survival</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Neoadjuvant Therapy</keyword><keyword>*Neoplasm Staging</keyword><keyword>Prognosis</keyword><keyword>Receptors, Estrogen/metabolism</keyword></keywords><dates><year>2011</year><pub-dates><date>May 20</date></pub-dates></dates><isbn>1527-7755 (Electronic)
0732-183X (Linking)</isbn><accession-num>21482989</accession-num><urls><related-urls><url> </url></related-urls></urls><language>eng</language></record></Cite></EndNote>[32]. Particularly in HR+HER2- breast cancer, pre-treatment variables are prognostic beyond residual disease measures ADDIN EN.CITE <EndNote><Cite><Author>Symmans</Author><Year>2013</Year><RecNum>171</RecNum><record><rec-number>171</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">171</key></foreign-keys><ref-type name="Conference Proceedings">10</ref-type><contributors><authors><author>Symmans, W.F.</author><author>Wei, C.</author><author>Gould, R.</author><author>Zhang, Y.</author><author>Hunt, K.K.</author><author>Buchholz, T.A.</author><author>Valero, V.</author><author>Hortobagyi, G.N.</author><author>Pusztai, L.</author><author>Hatzis, C.</author></authors></contributors><titles><title>Long-term prognostic value of residual cancer burden (RCB) classification following neoadjuvant chemotherapy [abstract S6-02]</title><secondary-title>San Antonio Breast Cancer Symposium</secondary-title></titles><dates><year>2013</year><pub-dates><date>10-14 Dec 2013</date></pub-dates></dates><pub-location>San Antonio, TX, USA</pub-location><urls></urls></record></Cite></EndNote>[61]. At present, we recommend both the RCB system and the current AJCC/ UICC staging system to quantify residual disease in neoadjuvant trials. The RCB score incorporates pCR as a score of zero and combines findings in the primary tumor bed (size and average cellularity of largest cross-section of residual tumor bed) and the regional lymph nodes (number of and size of largest metastases) to quantify increasing amounts of residual disease as an increasing continuous RCB score that is subdivided into four classes (0, I, II, and III) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TeW1tYW5zPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48
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ADDIN EN.CITE.DATA [24, 61]. A prescriptive protocol for pathologists is available at ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>32</RecNum><record><rec-number>32</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">32</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors></contributors><titles><title>Residual Cancer Burden calculator and associated documents [Guide for Measuring Cancer Cellularity, Examples of Gross & Microscopic Evaluation, Pathology Protocol for Macroscopic and Microscopic Assessment of RCB] Anderson Cancer Center, Houston, TX</publisher><urls><related-urls><url>;[23].CONCLUSIONSWe propose a standardized evaluation of the post-NAST surgical specimen in breast cancer neoadjuvant clinical trials that can be optionally incorporated into routine practice and promotes accuracy and reproducibility of response assessment across institutions. Rather than exhaustive sampling, thorough sampling in the areas of the specimen identified by informed mapping, taking into account clinical and imaging information, is needed. The standard proposed also allows collection of research tissue and better serves the study of response to NAST. pCR and RCB have robust long-term prognostic data for breast cancer overall and within phenotypic subsets. The AJCC/UICC yp-Staging system is internationally endorsed. Clearly identifying resection specimens as post-NAST is essential. We recommend that the post-NAST pathology evaluation include:The information needed to determine pCR versus residual disease, using either of the definitions proposed by the FDA meta-analysis (ypT0/is ypN0 or ypT0 ypN0). AJCC/UICC ypT and ypN stage. We recommend more detailed quantification of residual disease, Ideally the RCB system and/or any other classification system that is locally preferred or required for a clinical trial protocol relevant to the patient is included in the report. When RCB is not reported we advocate reporting the two-dimensional size of the largest distance between residual tumor cell nests in a cross-section of the entire area involved by residual tumor and identifying the relevant sections in the pathology report with at least a qualitative assessment of cellularity?across?this entire area.?We hope that direct, prospective comparisons of different classification systems will provide greater clarity for pathologic reporting of residual disease.Finally, the pathologic assessment of residual disease forms an important component of multivariate approaches that combine pre- and post-treatment burden of disease and biological characteristics to better define prognosis after NAST.Acknowledgments:We would like to thank the BIG-NABCG leadership:Dr. Nancy E. Davidson, MD, from University of Pittsburgh Cancer Institute and UPMC Cancer Center, Pittsburgh, PennsylvaniaDr. Martine Piccart, MD, PhD, of Institut Jules Bordet, Université Libre de Bruxelles, Brussels, BelgiumDr. Larry Norton, MD, Memorial Sloan Kettering Cancer Center, New York, New YorkWe also wish to thank the following for providing their input: Dr. Lesley Carson of Aberdeen Royal Infirmary, Foresterhill, Aberdeen, United Kingdom; Dr. Gyungyub Gong of Asan Medical Center, University of Ulsan College of Medicine, Korea; Dr. Benjamin Calhoun of Blumenthal Cancer Center, Carolinas Medical Center; Dr. Marc Wilt of Centre Paul Strauss, Strasbourg, France; Dr. David Peston of Charing Cross Hospital, London; Dr. Diana Dickson-Witmer and Mary Iacocca of Christiana Care, Delaware; Dr. Gary Unzeitig of Doctor's Hospital of Laredo, Texas; Dr. Kelly Marcom of Duke University, North Carolina; Dr. Paul Cane and Dr. Sarah Pinder of Guy’s St. Thomas’ Hospital, London; Dr Véronique Becette of Institut Curie / Centre René Huguenin, France; Dr. Roberto Salgado of Institut Jules Bordet, Belgium; Dr. Henry Gomez of Instituto Nacional de Enfermeda des Neoplasicas, Lima, Peru; Dr. Jelle Wesseling of Netherlands Cancer Institute; Dr. Jimmy Green and Susan Pekoe of Pathology Sciences Medical Group, P.C., Sentara Norfolk General, Leigh, Princess Anne and Obici Hospitals; Eastern Virginia Medical School, VA; Dr. Ling-Ming Tseng and C.Y. Hsu of Taipei-Veterans General Hospital, Dept of Surgery, Taipei; Dr. Wojtek Biernat of University in Gdansk, Dept of Pathology; Dr. Keith Amos of University of North Carolina, Chapel Hill; Dr. Gretchen Ahrendt of University of Pittsburgh Medical Center, PA; Dr. Marilyn Leitch and Dr. Venetia Sarode of UT Southwestern, Texas; Dr. Vicente Peg Cámara of Vall d'Hebron Hospital, Barcelona, Spain; Dr. Michael Idowu of Virginia Commonwealth University, Virginia; Dr. Peter Humphrey of Washington University, St. Louis, Missouri; Dr. Jeremy Thomas of Western General Hospital, NHS Lothian, Edinburgh; Dr. Soohyeon Lee of Yonsei University Severance Hospital, Korea; Dr. Aman Buzdar of MD Anderson Cancer Center, Texas; ?ngela Carrasco of GEICAM; Dr. William Sikov of Brown University, Rhode Island; Dr. Miguel Quintela of Centro Nacional de Investigaciones Oncológicas, Spain; Dr. Hervé Bonnefoi of Institut Bergonié, France; Dr. Ana Maria Gonzalez-Angulo of MD Anderson Cancer Center, Texas; Paolo Nuciforo of Vall d'Hebron Hospital, Barcelona, Spain; Dr. Sadie Reed and Dr. R. Charles Coombes of Imperial Cancer Clinical Research Unit, UK; Pinuccia Valagussa of Michelangelo Operations Office, Italy; Dr. Helena Earl of University of Cambridge Department of Oncology; Dr. Judith Kroep of Leiden University Medical Center, Netherlands; Dr. Terry Mamounas and Dr. Soon Paik of National Surgical Adjuvant Breast and Bowel Project ; Dr. Jean-Yves Pierga of Institut Curie, France.We would like to thank Rebecca Enos of the EMMES Corporation for information gathering and for coordination and administrative support of the BIG-NABCG Residual Disease Characterization Working Group. We would like to thank the Breast Cancer Research Foundation (BCRF) for its support of the BIG-NABCG collaboration, including the BIG-NABCG meeting where this working group was proposed.Disclosure:Dr. Symmans filed Residual Cancer Burden (RCB) as intellectual property (Nuvera Biosciences), patenting the RCB equation. (The RCB calculator is freely available on the worldwide web.) Dr. Symmans reports current stock in Nuvera Biosciences and past stock in Amgen. Dr. MacGrogan reports grants and personal fees from Roche, and personal fees from Sanofi Aventis, outside the submitted work.All remaining authors have declared no conflicts of interest.Table 1. Essential information to be provided to the pathologist with the surgical specimen removed after neoadjuvant systemic therapy Essential and critical information to be provided or made available to the pathologistThis information is very important to maintain a high quality of histopathological evaluation and to minimize turnaround time. A suggested requisition form is provided in the Supplementary Materials (Supplement 2).Comment1Clearly marked as post-NAST specimen.In daily clinical routine, this information is often not passed along to the pathologist. The pathologist should be informed of any previous therapy (hormonal therapy, chemotherapy, radiation therapy, and/or other therapy) for the cancer.2Is this part of a clinical trial?Does the trial protocol recommend a grading system for response?Important to follow trial protocol.Pathologist needs to know this information in advance of the surgery in order to follow protocol for description, processing, and reporting of the specimen. If this is a drug registration trial, the pathologist should be blinded to the treatment arm, or arrange for independent blinded secondary review of the case by another colleague. 3Results of previous core biopsies, especially if they were performed in another hospital.Core biopsy results: histologic type, grade, ER/PR, HER2, (and Ki67). Lab reference number. Ideally, slides should be available for review.4Pre-treatment lymph node status and method of assessment.This information is essential for a correct nodal status.If nodal status was assessed by sentinel lymph node (SLN) biopsy or percutaneous biopsy (core needle biopsy or fine needle aspiration biopsy) before neoadjuvant treatment, what were the results (number of nodes sampled, number of positive nodes, size of largest metastasis)? Was a clip placed in the sampled lymph node?5Clinical tumor size(s) before and after chemotherapy. The information is best given as size in cm or mm, rather than clinical tumor stage. Different imaging modalities may provide different sizes. This information is important to a) estimate the response to chemotherapy (=differences in tumor sizes) and b) to select the sampling area.If a large pre-therapeutic tumor has been diagnosed, the pathologist will perform a more extensive sampling to rule out multi-focal residual disease.If the clinical response is suggestive of a complete response, the pathologist will also do a more extensive sampling. In contrast, if the clinical evaluation suggests no response, the histopathological turnaround time can be reduced, as the extensive sampling might not be necessary.For multi-focal tumors, size of each tumor should be given.Imaging modality (mammography/ US/ MRI) and the chemotherapy cycle number at post-treatment imaging are informative, as are patterns of response (for example, scattered versus concentric shrinking).6Location of the tumor/ tumor bed / residual tumor after chemotherapy. The information is best given in a scheme/ drawing.This information is important in particular for large resection specimens. Detailed description of the location with, for example for mastectomy specimens, “o’clock radius” and distance from nipple is more helpful than just a quadrant.Procedure used for marking pre-treatment tumor location should be noted. Location ideally marked/ bracketed with clip (or ink) before rmation on presence of calcifications should be provided because associated calcifications could be used to localize a lesion.The surgeon can mark the location with a stitch on the specimen. Specimen radiography can help localize lesions, clips, and calcifications.For multi-focal tumors, location of each tumor should be given.7Information on close (for example <5mm) margins based on intra-operative findings/ specimen radiography.This is particularly relevant for large specimens. Close (for example <5mm) margins need a more extensive sampling.8Clinical and radiologic response to treatment in the axilla.Clinical exam is sensitive to disease greater than 1 cm in size.US is currently the imaging modality of choice for assessment of response in the axilla pre- and post-treatment and has the additional advantage of guiding percutaneous biopsy and clip placement to identify specific nodes for response evaluation at final histopathological evaluation.FNA: fine needle aspiration; CNB: core needle biopsy; SLN: sentinel lymph node; US: ultrasound; MRI: magnetic resonance imagingTable 2. Elements not always routinely included in the adjuvant setting but recommended in the pathology report of the post-NAST specimen.* Report the elements as for any other type of specimen, plus the following:CommentSize(A) Two dimensions of largest cross-section of entire area involved by (possibly scattered) residual invasive tumor foci (=largest distance between invasive tumor cell foci)and(B) Extent of largest contiguous focus of invasive carcinoma as recommended by AJCC 7th edition ADDIN EN.CITE <EndNote><Cite><Author>Edge</Author><Year>2009</Year><RecNum>47</RecNum><record><rec-number>47</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">47</key></foreign-keys><ref-type name="Edited Book">28</ref-type><contributors><authors><author>Edge, S. B. </author><author>Byrd, D. R. </author><author>Compton, C. C. </author><author>Fritz, A. G. </author><author>Greene, F. L. </author><author>Trotti, A. </author></authors></contributors><titles><title>American Joint Committee on Cancer (AJCC) Cancer Staging Manual, 7th edition</title></titles><dates><year>2009</year></dates><publisher>Springer</publisher><urls></urls></record></Cite></EndNote>[29] In the opinion of the working group, the largest dimension in (A) (longest black arrow), together with tumor cellularity, is likely a better indicator of response than measurement (B) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWphbjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [19, 31]. The report should clearly state how the size was determined and which dimension was used for staging, especially in cases with scattered residual disease, where there is possible inter-observer variability due to differences in guidelines regarding how size should be measured.(A) is needed to calculate the Residual Cancer Burden (RCB) score. Cellularity- Qualitative statement - Largest cross-section of residual tumor bed represented in blocks: … (for example, “G through F”)- Compare to pre-treatment cellularity if available (Miller-Payne or Pinder Systems)Assessment of average cancer cellularity across the largest cross-section of the residual tumor bed (that contains residual cancer) is needed to calculate the Residual Cancer Burden (RCB) score. Tumor bed- Identified or not - Presence of tumor bed at marginLymph node metastasis- Size of largest metastasisThe largest distance between tumor cell foci including intervening areas of fibrosis. Size of largest metastasis is needed to calculate the Residual Cancer Burden (RCB) score. Treatment effect- Presence of treatment effect in the breast- Number of lymph nodes with possible treatment effect *This table discusses only those elements specific to NAST that may not be routinely included in pathology reports for non- NAST specimens. A complete list of elements recommended in the pathology report of the post-NAST specimen can be found in our pathology-focused paper ADDIN EN.CITE <EndNote><Cite><Author>Provenzano</Author><Year>2015</Year><RecNum>188</RecNum><record><rec-number>188</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">188</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Provenzano, E.</author><author>Bossuyt, V.</author><author>Viale, G.</author><author>Cameron, D.</author><author>Badve, S.</author><author>Denkert, C.</author><author>MacGrogan, G.</author><author>Penault-Llorca, F.</author><author>Boughey, J. C.</author><author>Curigliano, G.</author><author>Dixon, J. Michael</author><author>Esserman, L. J.</author><author>Fastner, G.</author><author>Kuehn, T.</author><author>Peintinger, F.</author><author>von Minckwitz, G.</author><author>White, J.</author><author>Yang, W.</author><author>Symmans, W. F.</author></authors></contributors><titles><title>Standardization of pathologic evaluation and reporting of post-neoadjuvant specimens in clinical trials of breast cancer: Recommendations from an international working group</title><secondary-title>Modern Pathol</secondary-title></titles><periodical><full-title>Modern Pathol</full-title></periodical><volume>(In press)</volume><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[14]. Elements in bold are required for quantification of residual disease.Table 3. Requirements for accurate and reliable histologic assessment of pathologic complete response (pCR)----------------------------------------------------------------------------------------------------------Assessment of pathologic complete response (pCR) pCR = No residual invasive carcinoma in the breast and in all sampled lymph nodes(ypT0/is ypN0 or ypT0 ypN0) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db3J0YXphcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+
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ADDIN EN.CITE.DATA [1, 5]Requires adequate sampling of the correct area of the breast:Correlate area to sample with clinical and imaging findings (pre-treatment tumor size and location)Identify clip, if present/ tumor bedDocument the (largest) cross-section(s) of pre-treatment area of involvement with a map of the tissue blocks. (For initially large tumors, 5 representative blocks per 1-2 cm of pre-treatment size with maximum of about 25 blocks should be sufficient.)*Immunohistochemistry is not routinely required but may be helpful.All surgically removed lymph nodes must be entirely submitted for histologic evaluation, sectioned at 2 mm intervals. (Additional levels and immunohistochemistry are not routinely required.)Occasionally controversial elements:pCRNOT pCRInsufficient evidenceCommentDuctal carcinoma in situ (DCIS)xxpCR definitions vary PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db3J0YXphcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+
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ADDIN EN.CITE.DATA [1, 3, 59]; adding pT0 or pTis clarifies the pCR definitionLobular carcinoma in situxLymphovascular invasion (LVI)xxVery rarely a problem for designation as pCR or not because significant LVI-only residual disease without residual disease in the lymph nodes is extremely rare.Micro and macrometastasis in lymph node(s) (pN1mic and above)xResidual disease in the lymph nodes confers a worse prognosis irrespective of the presence of disease in the breast PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW1vdW5hczwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+
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ADDIN EN.CITE.DATA [7, 34-40].The significance of micrometastases and isolated tumor cells is different in the neoadjuvant setting than in the adjuvant setting PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GaXNoZXI8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [42].Isolated tumor cells in lymph node(s) (pN0i+)x* The FDA have recommended a minimum of one block per cm of pre-treatment tumor size or at least 10 blocks in total whichever is greater ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1"><Year>2014</Year><RecNum>29</RecNum><record><rec-number>29</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">29</key></foreign-keys><ref-type name="Government Document">46</ref-type><contributors></contributors><titles><title>U.S. Food and Drug Administration. Guidance for Industry: Pathological Complete Response in Neoadjuvant Treatment of High-Risk Early-Stage Breast Cancer: Use as an Endpoint to Support Accelerated Approval. October 2014. </title></titles><pages>;[5].Figure 1. Different patterns of response in the breast and problems related to sampling for histologic evaluation: schematic overview with gross and microscopic illustrations Photos courtesy of Veerle BossuytA. In some cases with complete response, a residual tumor bed is visible. In others, the tumor bed is indistinct and sampling of the correct area can only be confirmed by thorough clinical and imaging correlation and identification of a clip. Often, residual microscopic disease is identified when there is no residual tumor grossly. Photos left to right: Gross photograph of tumor bed (arrow). Low-power H&E slide of this tumor bed. No residual tumor is identified. High-power of H&E slide of the tumor bed from a different patient with rare residual invasive carcinoma cells (small arrows).B. A partial response ranges from a decrease in cellularity with unchanged tumor size to concentric tumor shrinking with a marked decrease in tumor size but unchanged tumor cellularity. Often the decrease in cellularity is heterogeneous, with residual disease commonly extending beyond the grossly visible tumor bed. Photos left to right: Gross photograph of tumor bed with residual tumor (arrow). H&E slides (low and high power) of different patient with tumor bed and residual invasive carcinoma concentrated in a nodule within the tumor bed with high cellularity. Concentric shrinking.C. When decrease in cellularity is heterogeneous, random sampling of tumor can lead to very different estimates of tumor cellularity. Microscopic examination of the three black blocks in the schematic would show a relatively unchanged cellularity (almost no response), whereas sampling with the blue blocks would show a markedly decreased cellularity (significant response). The decrease in cellularity can be so heterogeneous that there are apparent areas with complete response (no residual disease) and apparent multiple foci of residual tumor. Random sampling with the blue blocks would conclude a complete response. Random sampling with the black blocks would document residual disease. In these cases with a “scatter pattern,” there is inter-observer variability in size measurements and inconsistencies among guidelines. For example, for AJCC staging, the largest contiguous focus of invasive carcinoma should be measured ADDIN EN.CITE <EndNote><Cite><Author>Edge</Author><Year>2009</Year><RecNum>47</RecNum><record><rec-number>47</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">47</key></foreign-keys><ref-type name="Edited Book">28</ref-type><contributors><authors><author>Edge, S. B. </author><author>Byrd, D. R. </author><author>Compton, C. C. </author><author>Fritz, A. G. </author><author>Greene, F. L. </author><author>Trotti, A. </author></authors></contributors><titles><title>American Joint Committee on Cancer (AJCC) Cancer Staging Manual, 7th edition</title></titles><dates><year>2009</year></dates><publisher>Springer</publisher><urls></urls></record></Cite></EndNote>[29]. Intervening areas of fibrosis are specifically excluded, whereas other systems include these areas. Moreover, there can be inter-observer variability in how much fibrosis to allow within this largest contiguous focus. Photos left to right: Gross photograph of most common pattern of residual disease with scattered residual tumor across a fibrous tumor bed. Medium power of H&E slides from two different blocks of the tumor bed (black and blue boxes) illustrating that cellularity often varies greatly from block to block.Figure 2. Example of mapping of a post-NAST lumpectomy specimenThe specimen is serially sliced and radiographed (A). A diagram allows the pathologist to correlate the microscopic findings with the gross findings and the specimen radiograph and to reconstruct the location of the microscopic residual disease in the specimen for size measurements (B) ADDIN EN.CITE <EndNote><Cite><Author>Symmans</Author><Year>2013</Year><RecNum>169</RecNum><record><rec-number>169</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">169</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Symmans, W.F.</author></authors></contributors><titles><title>Pathologic Evaluation after Neoadjuvant Chemotherapy. American Association for Cancer Research (AACR) Annual Meeting, Washington, DC. ;[63]. The cellularity is assessed across the largest cross-section of residual microscopic disease and compared to a computer-generated standard to improve reproducibility (C) ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>32</RecNum><record><rec-number>32</rec-number><foreign-keys><key app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">32</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors></contributors><titles><title>Residual Cancer Burden calculator and associated documents [Guide for Measuring Cancer Cellularity, Examples of Gross & Microscopic Evaluation, Pathology Protocol for Macroscopic and Microscopic Assessment of RCB] Anderson Cancer Center, Houston, TX</publisher><urls><related-urls><url> app="EN" db-id="df2swszadvvdrfea9fa5fp53xpt5sa02s9tw">169</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Symmans, W.F.</author></authors></contributors><titles><title>Pathologic Evaluation after Neoadjuvant Chemotherapy. American Association for Cancer Research (AACR) Annual Meeting, Washington, DC. ;[23, 63]. (The average cellularity in this example is approximately 30%.)Source: Symmans WF. “Pathologic Evaluation after Neoadjuvant Chemotherapy.” American Association for Cancer Research (AACR) Annual Meeting: Washington, DC, USA; 2013. ADDIN EN.REFLIST 1.Cortazar P, Zhang L, Untch M et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet 2014; 384: 164-172.2.Esserman LJ, Berry DA, DeMichele A et al. Pathologic complete response predicts recurrence-free survival more effectively by cancer subset: results from the I-SPY 1 TRIAL--CALGB 150007/150012, ACRIN 6657. J Clin Oncol 2012; 30: 3242-3249.3.von Minckwitz G, Untch M, Blohmer JU et al. Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol 2012; 30: 1796-1804.4.Esserman LJ, Woodcock J. 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