What is the difference between LGL leukemia and chronic ...

[Pages:3]What is the difference between LGL leukemia and chronic lymphocytic leukemia (CLL)?

Copyright 2017 by the Rector and Visitors of the University of Virginia

A.

Non-White Blood Cells

What is the difference between LGL leukemia and chronic lymphocytic leukemia (CLL)?

Types of Blood Cells White Blood Cells

Red blood cell Platelet Neutrophil Eosinophil Basophil Lymphocyte Monocyte

This diagram shows all the different types of blood cells, and groups them as either nonwhite blood cells or white blood cells.

We are going to focus on the lymphocytes. There are three types: T-cell, NK-cell, and B-cell.

T-cells

NK-cells

B-cells

Copyright 2017 by the Rector and Visitors of the University of Virginia

What is the difference between LGL leukemia and chronic lymphocytic leukemia (CLL)?

B.

Types of Lymphocytes

T-LGL or NK-LGL Leukemia

CD3 CD8 CD57 TCR

CD16 CD56CD94

B-cell CLL

CD19

CD5

CD23

T-cells

NK-cells

B-cells

In LGL leukemia, T- or NK-cells become clonal (make B-cells, another type of lymphocyte,

copies of themselves). The different markers

become clonal. This cell has different

indicate which cell is clonal.

markers.

Previous content described how a diagnosis is made In the case of CLL, this is a cancer of the

for either case, but briefly, it is based on the cell

B-cells, which are also lymphocytes. In

markers (CD proteins) and for T-LGLL the TCR gene

this case, there are different CD markers

rearrangement test establishes clonality.

which are used in identifying that this cell

type has expanded and made many

copies of itself.

Copyright 2017 by the Rector and Visitors of the University of Virginia

 ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download