Management of Postpartum Hemorrhage

Comparative Effectiveness Review Number 151

Management of Postpartum Hemorrhage

Comparative Effectiveness Review

Number 151

Management of Postpartum Hemorrhage

Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 540 Gaither Road Rockville, MD 20850

Contract No. 290-2012-00009-I

Prepared by: Vanderbilt Evidence-based Practice Center Nashville, TN

Investigators: Frances E. Likis, Dr.P.H., N.P., C.N.M., FACNM, FAAN Nila A. Sathe, M.A., M.L.I.S. Alicia K. Morgans, M.D. Katherine E. Hartmann, M.D., Ph.D. Jessica L. Young, M.D., M.P.H. Daphne Carlson-Bremer, D.V.M., M.P.V.M., Ph.D. Mavis Schorn, Ph.D., A.P.R.N., C.N.M. Tanya Surawicz, M.P.H. Jeff Andrews, M.D.

AHRQ Publication No. 15-EHC013-EF April 2015

This report is based on research conducted by the Vanderbilt Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2012-00009-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help health care decisionmakers--patients and clinicians, health system leaders, and policymakers, among others--make well informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients.

AHRQ or U.S. Department of Health and Human Services endorsement of any derivative products that may be developed from this report, such as clinical practice guidelines, other quality enhancement tools, or reimbursement or coverage policies, may not be stated or implied.

This report may periodically be assessed for the currency of conclusions. If an assessment is done, the resulting surveillance report describing the methodology and findings will be found on the Effective Health Care Program Web site at effectivehealthcare.. Search on the title of the report.

This document is in the public domain and may be used and reprinted without special permission. Citation of the source is appreciated.

Persons using assistive technology may not be able to fully access information in this report. For assistance contact EffectiveHealthCare@ahrq..

None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report.

Suggested citation: Likis FE, Sathe NA, Morgans AK, Hartmann KE, Young JL, CarlsonBremer D, Schorn M, Surawicz T, Andrews J. Management of Postpartum Hemorrhage. Comparative Effectiveness Review No. 151. (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2012-00009-I.) AHRQ Publication No. 15-EHC013-EF. Rockville, MD: Agency for Healthcare Research and Quality; April 2015. effectivehealthcare.reports/final.cfm.

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Preface

The Agency for Healthcare Research and Quality (AHRQ), through its Evidence-based Practice Centers (EPCs), sponsors the development of systematic reviews to assist public- and private-sector organizations in their efforts to improve the quality of health care in the United States. These reviews provide comprehensive, science-based information on common, costly medical conditions, and new health care technologies and strategies.

Systematic reviews are the building blocks underlying evidence-based practice; they focus attention on the strength and limits of evidence from research studies about the effectiveness and safety of a clinical intervention. In the context of developing recommendations for practice, systematic reviews can help clarify whether assertions about the value of the intervention are based on strong evidence from clinical studies. For more information about AHRQ EPC systematic reviews, see effectivehealthcare.reference/purpose.cfm.

AHRQ expects that these systematic reviews will be helpful to health plans, providers, purchasers, government programs, and the health care system as a whole. Transparency and stakeholder input are essential to the Effective Health Care Program. Please visit the Web site (effectivehealthcare.) to see draft research questions and reports or to join an email list to learn about new program products and opportunities for input.

We welcome comments on this systematic review. They may be sent by mail to the Task Order Officer named below at: Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, or by email to epc@ahrq..

Richard G. Kronick, Ph.D. Director Agency for Healthcare Research and Quality

David Meyers, M.D. Acting Director Center for Evidence and Practice Improvement Agency for Healthcare Research and Quality

Stephanie Chang, M.D., M.P.H. Director, EPC Program Center for Evidence and Practice Improvement Agency for Healthcare Research and Quality

Suchitra Iyer, Ph.D. Task Order Officer Center for Evidence and Practice Improvement Agency for Healthcare Research and Quality

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Acknowledgments

The authors gratefully acknowledge the following individuals for their contributions to this project: Dr. Melissa McPheeters provided valuable input and methodologic insight throughout the review process. Ms. Rachel Walden executed the literature searches and assisted with screening studies and drafting tables. Ms. Sanura Latham and Ms. Jessica Kimber assisted with locating articles and formatting tables. Ms. Katie Worley managed the topic refinement period and assisted with developing the review protocol.

Key Informants

In designing the study questions, the EPC consulted several Key Informants who represent the end-users of research. The EPC sought the Key Informant input on the priority areas for research and synthesis. Key Informants are not involved in the analysis of the evidence or the writing of the report. Therefore, in the end, study questions, design, methodological approaches, and/or conclusions do not necessarily represent the views of individual Key Informants.

Key Informants must disclose any financial conflicts of interest greater than $10,000 and any other relevant business or professional conflicts of interest. Because of their role as end-users, individuals with potential conflicts may be retained. The TOO and the EPC work to balance, manage, or mitigate any conflicts of interest.

The list of Key Informants who participated in developing this report follows:

Debra Bingham, Dr.P.H., R.N., FAAN Association of Women's Health, Obstetric & Neonatal Nurses (AWHONN) Washington, DC

Deborah B. Karsnitz, D.N.P., C.N.M., FACNM Frontier Nursing University Hyden, KY

Valerie King, M.D., M.P.H. Oregon Health & Science University Portland, OR

Audrey Lyndon, Ph.D., R.N.C., FAAN University of California, San Francisco San Francisco, CA

Amy Marowitz, D.N.P., C.N.M. Frontier Nursing University Hyden, KY

David C. Mayer, M.D. University of North Carolina Chapel Hill, NC

Carolyn Zelop, MD The Valley Hospital Ridgewood, NJ New York University School of Medicine New York, NY

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