RADIATION THERAPY ONCOLOGY GROUP - MD Anderson …
Rosiglitazone, a CYP2C8 substrate, was given with vismodegib at steady state with no clinically significant change in rosiglitazone exposure, suggesting that there is no clinically significant inhibition of CYP2C8 by vismodegib. Vismodegib was also found in vitro to be a substrate of the efflux p-glycoprotein transporter. ................
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