Supplemental Digital Content - Lippincott Williams & Wilkins
Supplemental Digital ContentSDC 1, Glossary of termsAcute Tubular InjuryThere is no current definition of acute tubular injury endorsed by the Banff classification. Acute Tubular Injury In the Absence Of Any Other Apparent Cause is included as one of the criteria for histological evidence of acute tissue injury in the diagnosis of Active AMR.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1) Moreover, Acute Tubular Injury without other specification is included as a diagnosis in Banff Diagnostic Category 6.Antibody-mediated rejection (AMR)Antibody-mediated rejection (AMR) refers to a rejection process believed to be primarily driven by antibodies against graft epitopes. Diagnostic criteria are listed under Banff Diagnostic Category 2 of the 2017 Banff update.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1) Diagnostic subcategories within include the following; C4d Staining Without Evidence of Rejection, Active AMR, Chronic Active AMR, Chronic AMR. AMR can coexist with additional diagnoses from Banff Diagnostic Categories 3-6.Adequacy of SpecimenSince Banff 1997PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWN1c2VuPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWN1c2VuPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48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ADDIN EN.CITE.DATA (2) a biopsy has been considered adequate if it contains at least 10 or more glomeruli and at least 2 arteries; the threshold for a “minimal sample” is 7 glomeruli and 1 artery. It is also recommended that at least 2 separate cores containing cortex be obtained or that there be 2 separate areas of cortex in the same core.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE.DATA (3)ArterioleDerived from the definition of arteries below, the definition of arterioles is consequently arterial vessels having less than two smooth muscle layers.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE.DATA (3) Changes in arterioles are currently not recognised as contributory to Banff Lesion Score v or cv.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1) Arteriolar inflammation is noted with an asterisk behind Banff Lesion Score ah, e.g. ah2*.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWN1c2VuPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWN1c2VuPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48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ADDIN EN.CITE.DATA (2)Arteritis, IntimalArteritis is synonymous with endarteritis or arterial endothelialitis. According to Banff 2015, intimal arteritis as per Banff Lesion Score v1, v2 is defined as mononuclear cell infiltration beneath the arterial endothelium. Severe arteritis v3 is defined by inflammation in the media and/or fibrinoid necrosis of the vessel wall; the total number of arteries in the biopsy and the number of arteries affected should be noted.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE.DATA (3) Marginated leukocytes alone are insufficient to diagnose arteritis.ArterySince Banff 2013PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj
TnVtPjUxNjc8L1JlY051bT48RGlzcGxheVRleHQ+KDxzdHlsZSBmYWNlPSJpdGFsaWMiPjQ8L3N0
eWxlPik8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NTE2NzwvcmVjLW51bWJlcj48
Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjkwdHBzenN3YmZzMmYzZXZzdzh2ejlh
NTJ2cnA5ZTJ4YTk1ZSIgdGltZXN0YW1wPSIwIj41MTY3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJl
Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+
PGF1dGhvcnM+PGF1dGhvcj5IYWFzLCBNLjwvYXV0aG9yPjxhdXRob3I+U2lzLCBCLjwvYXV0aG9y
PjxhdXRob3I+UmFjdXNlbiwgTC4gQy48L2F1dGhvcj48YXV0aG9yPlNvbGV6LCBLLjwvYXV0aG9y
PjxhdXRob3I+R2xvdHosIEQuPC9hdXRob3I+PGF1dGhvcj5Db2x2aW4sIFIuIEIuPC9hdXRob3I+
PGF1dGhvcj5DYXN0cm8sIE0uIEMuPC9hdXRob3I+PGF1dGhvcj5EYXZpZCwgRC4gUy48L2F1dGhv
cj48YXV0aG9yPkRhdmlkLU5ldG8sIEUuPC9hdXRob3I+PGF1dGhvcj5CYWduYXNjbywgUy4gTS48
L2F1dGhvcj48YXV0aG9yPkNlbmRhbGVzLCBMLiBDLjwvYXV0aG9yPjxhdXRob3I+Q29ybmVsbCwg
TC4gRC48L2F1dGhvcj48YXV0aG9yPkRlbWV0cmlzLCBBLiBKLjwvYXV0aG9yPjxhdXRob3I+RHJh
Y2hlbmJlcmcsIEMuIEIuPC9hdXRob3I+PGF1dGhvcj5GYXJ2ZXIsIEMuIEYuPC9hdXRob3I+PGF1
dGhvcj5GYXJyaXMsIEEuIEIuLCAzcmQ8L2F1dGhvcj48YXV0aG9yPkdpYnNvbiwgSS4gVy48L2F1
dGhvcj48YXV0aG9yPktyYXVzLCBFLjwvYXV0aG9yPjxhdXRob3I+TGlhcGlzLCBILjwvYXV0aG9y
PjxhdXRob3I+TG91cHksIEEuPC9hdXRob3I+PGF1dGhvcj5OaWNrZWxlaXQsIFYuPC9hdXRob3I+
PGF1dGhvcj5SYW5kaGF3YSwgUC48L2F1dGhvcj48YXV0aG9yPlJvZHJpZ3VleiwgRS4gUi48L2F1
dGhvcj48YXV0aG9yPlJ1c2gsIEQuPC9hdXRob3I+PGF1dGhvcj5TbWl0aCwgUi4gTi48L2F1dGhv
cj48YXV0aG9yPlRhbiwgQy4gRC48L2F1dGhvcj48YXV0aG9yPldhbGxhY2UsIFcuIEQuPC9hdXRo
b3I+PGF1dGhvcj5NZW5nZWwsIE0uPC9hdXRob3I+PGF1dGhvcj5hcyB0aGUgQmFuZmYgbWVldGlu
ZyByZXBvcnQgd3JpdGluZywgY29tbWl0dGVlPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0
b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQYXRob2xvZ3kgYW5kIExhYm9yYXRvcnkg
TWVkaWNpbmUsIENlZGFycy1TaW5haSBNZWRpY2FsIENlbnRlciwgTG9zIEFuZ2VsZXMsIENBLjwv
YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkJhbmZmIDIwMTMgbWVldGluZyByZXBvcnQ6IGlu
Y2x1c2lvbiBvZiBjNGQtbmVnYXRpdmUgYW50aWJvZHktbWVkaWF0ZWQgcmVqZWN0aW9uIGFuZCBh
bnRpYm9keS1hc3NvY2lhdGVkIGFydGVyaWFsIGxlc2lvbnM8L3RpdGxlPjxzZWNvbmRhcnktdGl0
bGU+QW0gSiBUcmFuc3BsYW50PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5BbWVyaWNhbiBq
b3VybmFsIG9mIHRyYW5zcGxhbnRhdGlvbiA6IG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEFtZXJp
Y2FuIFNvY2lldHkgb2YgVHJhbnNwbGFudGF0aW9uIGFuZCB0aGUgQW1lcmljYW4gU29jaWV0eSBv
ZiBUcmFuc3BsYW50IFN1cmdlb25zPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1
bGwtdGl0bGU+QW0gSiBUcmFuc3BsYW50PC9mdWxsLXRpdGxlPjxhYmJyLTE+QW1lcmljYW4gam91
cm5hbCBvZiB0cmFuc3BsYW50YXRpb24gOiBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBBbWVyaWNh
biBTb2NpZXR5IG9mIFRyYW5zcGxhbnRhdGlvbiBhbmQgdGhlIEFtZXJpY2FuIFNvY2lldHkgb2Yg
VHJhbnNwbGFudCBTdXJnZW9uczwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+
PGZ1bGwtdGl0bGU+QW0gSiBUcmFuc3BsYW50PC9mdWxsLXRpdGxlPjxhYmJyLTE+QW1lcmljYW4g
am91cm5hbCBvZiB0cmFuc3BsYW50YXRpb24gOiBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBBbWVy
aWNhbiBTb2NpZXR5IG9mIFRyYW5zcGxhbnRhdGlvbiBhbmQgdGhlIEFtZXJpY2FuIFNvY2lldHkg
b2YgVHJhbnNwbGFudCBTdXJnZW9uczwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjI3
Mi04MzwvcGFnZXM+PHZvbHVtZT4xNDwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxlZGl0aW9u
PjIwMTQvMDEvMzA8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIGFsbG9ncmFmdCBy
ZWplY3Rpb248L2tleXdvcmQ+PGtleXdvcmQ+QmFuZmYgc2NoZW1hPC9rZXl3b3JkPjxrZXl3b3Jk
PmFudGlib2R5LW1lZGlhdGVkIHJlamVjdGlvbjwva2V5d29yZD48a2V5d29yZD5jYXJkaWFjIGFs
bG9ncmFmdDwva2V5d29yZD48a2V5d29yZD5jaHJvbmljIGFsbG9ncmFmdCByZWplY3Rpb248L2tl
eXdvcmQ+PGtleXdvcmQ+Y29tcGxlbWVudCBDNGQ8L2tleXdvcmQ+PGtleXdvcmQ+Y29tcG9zaXRl
IHRpc3N1ZSBhbGxvZ3JhZnQ8L2tleXdvcmQ+PGtleXdvcmQ+ZG9ub3Itc3BlY2lmaWMgYW50aWJv
ZGllczwva2V5d29yZD48a2V5d29yZD5saXZlciBhbGxvZ3JhZnQ8L2tleXdvcmQ+PGtleXdvcmQ+
bHVuZyB0cmFuc3BsYW50YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+cGFuY3JlYXMgYWxsb2dyYWZ0
PC9rZXl3b3JkPjxrZXl3b3JkPnJlbmFsIHRyYW5zcGxhbnRhdGlvbjwva2V5d29yZD48a2V5d29y
ZD50cmFuc3BsYW50IGJpb3BzeTwva2V5d29yZD48a2V5d29yZD50cmFuc3BsYW50IGdsb21lcnVs
b3BhdGh5PC9rZXl3b3JkPjxrZXl3b3JkPnRyYW5zcGxhbnQgcGF0aG9sb2d5PC9rZXl3b3JkPjwv
a2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWI8L2Rh
dGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNjAwLTYxNDMgKEVsZWN0cm9uaWMpJiN4RDsx
NjAwLTYxMzUgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NDcyMTkwPC9hY2Nlc3Np
b24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5n
b3YvcHVibWVkLzI0NDcyMTkwPC91cmw+PHVybD5odHRwOi8vb25saW5lbGlicmFyeS53aWxleS5j
b20vc3RvcmUvMTAuMTExMS9hanQuMTI1OTAvYXNzZXQvYWp0MTI1OTAucGRmP3Y9MSZhbXA7dD1o
cjZra3doaSZhbXA7cz0xNDhmOTliZDViNTNmZTI1YzY3YmVkMTMyMWNhNWUyZThkMjUzMTdhPC91
cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTEx
L2FqdC4xMjU5MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k
Tm90ZT4A
ADDIN EN.CITE.DATA (4) an artery has been defined by “having a continuous media with two or more smooth muscle layers”.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE.DATA (3)Borderline ChangesThis refers to Banff Diagnostic Category 3 “Suspicious (Borderline) for Acute TCMR”.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1) This can be used in conjunction with other Banff categories with the exception of Category 1 (Normal Biopsy Or Nonspecific Changes) or 4 (Acute TCMR Grade IA, IIA, IIB or III, Chronic active TCMR Grade IA, IB or II).C4dComplement component 4 fragment d (C4d) is a degradation product of complement component C4, which can bind covalently to the endothelial cell surface.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWdlbGU8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWdlbGU8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (5) Positive immunostaining indicates local complement activation and is scored with Banff Lesion Score C4d.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE.DATA (3) The clinical significance of these findings is different in grafts exposed to anti-blood group antibodies (ABO-incompatible allografts), in which isoagglutinin-mediated complement activation does not appear to be injurious to the graft and may represent accommodation. However, when caused by donor-specific antibodies against HLA or other antigens, it may indicate AMR activity. Based on the high specificity of C4d positivity, it is considered equivalent to the serological proof of donor-specific antibody (DSA) for a diagnosis of AMR, although it is still recommended to test for DSA.Banff Diagnostic CategoriesThis refers to the six consensus-based and empirically validated Banff Diagnostic Categories (1 to 6) for renal allograft biopsies.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1) Diagnoses from different Banff Diagnostic Categories can be used if required in any combination other than Category 1, 3 and 4 which are mutually exclusive. Moreover, any diagnosis from Categories 2-6 excludes Banff Diagnostic Category 1 (Normal Biopsy or Nonspecific changes). Multiple diagnoses from a single Banff Diagnostic Category can only be made from Category 6.Banff Lesion ScoresBanff Lesion Scores are descriptive, consensus-based, standardised terms to grade important active and chronic histopathological findings in the different morphological compartments of the renal transplant. Although they are an integral part of the minimal dataset, they are by themselves not necessarily sufficient to determine Banff Diagnostic Categories. Chronic Allograft ArteriopathyChronic Allograft Arteriopathy is a feature of Chronic Active TCMR and Chronic Active AMR. It is defined as arterial intimal fibrosis with mononuclear cell infiltration in fibrosis and/or formation of neointima. The Banff Lesion Score cv is used to grade it, based on the extent of luminal occlusion in the most severely affected artery. Lack of prior biopsy-proven TCMR favours a diagnosis of Chronic Active AMR.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj
TnVtPjEwNzgyPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig8c3R5bGUgZmFjZT0iaXRhbGljIj4xPC9z
dHlsZT4pPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjEwNzgyPC9yZWMtbnVtYmVy
Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOTB0cHN6c3diZnMyZjNldnN3OHZ6
OWE1MnZycDllMnhhOTVlIiB0aW1lc3RhbXA9IjE1MTUwNjQzMzIiPjEwNzgyPC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYWFzLCBNLjwvYXV0aG9yPjxhdXRob3I+TG91
cHksIEEuPC9hdXRob3I+PGF1dGhvcj5MZWZhdWNoZXVyLCBDLjwvYXV0aG9yPjxhdXRob3I+Um91
Zm9zc2UsIEMuPC9hdXRob3I+PGF1dGhvcj5HbG90eiwgRC48L2F1dGhvcj48YXV0aG9yPlNlcm9u
LCBELjwvYXV0aG9yPjxhdXRob3I+TmFua2l2ZWxsLCBCLiBKLjwvYXV0aG9yPjxhdXRob3I+SGFs
bG9yYW4sIFAuIEYuPC9hdXRob3I+PGF1dGhvcj5Db2x2aW4sIFIuIEIuPC9hdXRob3I+PGF1dGhv
cj5BbGFjaGthciwgTi48L2F1dGhvcj48YXV0aG9yPkJhZ25hc2NvLCBTLjwvYXV0aG9yPjxhdXRo
b3I+Qm91YXRvdSwgWS48L2F1dGhvcj48YXV0aG9yPkJlY2tlciwgSi4gVS48L2F1dGhvcj48YXV0
aG9yPkNvcm5lbGwsIEwuPC9hdXRob3I+PGF1dGhvcj5EdW9uZyB2YW4gSHV5ZW4sIEouIFAuPC9h
dXRob3I+PGF1dGhvcj5HaWJzb24sIEkuPC9hdXRob3I+PGF1dGhvcj5NYW5ub24sIFIuPC9hdXRo
b3I+PGF1dGhvcj5OYWVzZW5zLCBNLjwvYXV0aG9yPjxhdXRob3I+Tmlja2VsZWl0LCBWLjwvYXV0
aG9yPjxhdXRob3I+Tmlja2Vyc29uLCBQLjwvYXV0aG9yPjxhdXRob3I+U2VnZXYsIEQuIEwuPC9h
dXRob3I+PGF1dGhvcj5TaW5naCwgSC4gSy48L2F1dGhvcj48YXV0aG9yPlN0ZWdhbGwsIE0uPC9h
dXRob3I+PGF1dGhvcj5SYW5kaGF3YSwgUC48L2F1dGhvcj48YXV0aG9yPlJhY3VzZW4sIEwuPC9h
dXRob3I+PGF1dGhvcj5Tb2xleiwgSy48L2F1dGhvcj48YXV0aG9yPk1lbmdlbCwgTS48L2F1dGhv
cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBh
dGhvbG9neSAmYW1wOyBMYWJvcmF0b3J5IE1lZGljaW5lLCBDZWRhcnMtU2luYWkgTWVkaWNhbCBD
ZW50ZXIsIExvcyBBbmdlbGVzLCBDQSwgVVNBLiYjeEQ7UGFyaXMgVHJhbnNsYXRpb25hbCBSZXNl
YXJjaCBDZW50ZXIgZm9yIG9yZ2FuIHRyYW5zcGxhbnRhdGlvbiBJTlNFUk0gVTk3MCAmYW1wOyBO
ZWNrZXIgSG9zcGl0YWwgVW5pdmVyc2l0eSBQYXJpcyBEZXNjYXJ0ZXMsIFBhcmlzLCBGcmFuY2Uu
JiN4RDtQYXJpcyBUcmFuc2xhdGlvbmFsIFJlc2VhcmNoIENlbnRlciBmb3Igb3JnYW4gdHJhbnNw
bGFudGF0aW9uICZhbXA7IERlcGFydG1lbnQgb2YgTmVwaHJvbG9neSBhbmQgVHJhbnNwbGFudGF0
aW9uLCBIb3BpdGFsIFNhaW50IExvdWlzLCBVbml2ZXJzaXRlIFBhcmlzIFZJSSBhbmQgSU5TRVJN
IFUgMTE2MCwgUGFyaXMsIEZyYW5jZS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUsIEltcGVy
aWFsIENvbGxlZ2UgTG9uZG9uIGFuZCBOb3J0aCBXZXN0IExvbmRvbiBQYXRob2xvZ3ksIExvbmRv
biwgVUsuJiN4RDtOZXBocm9sb2d5IERlcGFydG1lbnQsIEhvc3BpdGFsIFZhbGwgZCZhcG9zO0hl
YnJvbiwgQXV0b25vbW91cyBVbml2ZXJzaXR5IG9mIEJhcmNlbG9uYSwgU3BhaW4uJiN4RDtEZXB0
LiBvZiBSZW5hbCBNZWRpY2luZSwgV2VzdG1lYWQgSG9zcGl0YWwsIFN5ZG5leSwgQXVzdHJhbGlh
LiYjeEQ7QWxiZXJ0YSBUcmFuc3BsYW50IEFwcGxpZWQgR2Vub21pY3MgQ2VudHJlLCBVbml2ZXJz
aXR5IG9mIEFsYmVydGEsIEVkbW9udG9uLCBBbGJlcnRhLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50
IG9mIFBhdGhvbG9neSwgTWFzc2FjaHVzZXR0cyBHZW5lcmFsIEhvc3BpdGFsLCBIYXJ2YXJkIE1l
ZGljYWwgU2Nob29sLCBCb3N0b24sIE1BLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5l
LCBTZWN0aW9uIG9mIE5lcGhyb2xvZ3ksIEpvaG5zIEhvcGtpbnMgVW5pdmVyc2l0eSBTY2hvb2wg
b2YgTWVkaWNpbmUsIEJhbHRpbW9yZSwgTUQsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgUGF0aG9s
b2d5LCBKb2hucyBIb3BraW5zIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBCYWx0aW1v
cmUsIE1ELCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljYWwgU3BlY2lhbGl0aWVzLCBEaXZp
c2lvbiBvZiBOZXBocm9sb2d5LCBHZW5ldmEgVW5pdmVyc2l0eSBIb3NwaXRhbHMsIEdlbmV2YSwg
U3dpdHplcmxhbmQuJiN4RDtJbnN0aXR1dGUgb2YgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IEhvc3Bp
dGFsIG9mIENvbG9nbmUsIENvbG9nbmUsIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIExhYm9y
YXRvcnkgTWVkaWNpbmUgYW5kIFBhdGhvbG9neSwgTWF5byBDbGluaWMsIFJvY2hlc3RlciwgTU4s
IFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IG9mIE1hbml0b2Jh
LCBXaW5uaXBlZywgQ2FuYWRhLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgRGl2aXNpb24g
b2YgTmVwaHJvbG9neSwgVW5pdmVyc2l0eSBvZiBBbGFiYW1hIFNjaG9vbCBvZiBNZWRpY2luZSwg
QmlybWluZ2hhbSwgQUwsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTWljcm9iaW9sb2d5IGFuZCBJ
bW11bm9sb2d5LCBVbml2ZXJzaXR5IG9mIExldXZlbiAmYW1wOyBEZXBhcnRtZW50IG9mIE5lcGhy
b2xvZ3ksIFVuaXZlcnNpdHkgSG9zcGl0YWxzIExldXZlbiwgTGV1dmVuLCBCZWxnaXVtLiYjeEQ7
RGl2aXNpb24gb2YgTmVwaHJvcGF0aG9sb2d5LCBEZXBhcnRtZW50IG9mIFBhdGhvbG9neSBhbmQg
TGFib3JhdG9yeSBNZWRpY2luZSwgVGhlIFVuaXZlcnNpdHkgb2YgTm9ydGggQ2Fyb2xpbmEgU2No
b29sIG9mIE1lZGljaW5lLCBDaGFwZWwgSGlsbCwgTkMsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2Yg
SW50ZXJuYWwgTWVkaWNpbmUgYW5kIEltbXVub2xvZ3ksIFVuaXZlcnNpdHkgb2YgTWFuaXRvYmEs
IFdpbm5pcGVnLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50IG9mIFN1cmdlcnksIEpvaG5zIEhvcGtp
bnMgTWVkaWNhbCBJbnN0aXR1dGlvbnMsIEJhbHRpbW9yZSwgTUQsIFVTQS4mI3hEO0RlcGFydG1l
bnRzIG9mIFN1cmdlcnkgYW5kIEltbXVub2xvZ3ksIE1heW8gQ2xpbmljLCBSb2NoZXN0ZXIsIE1O
LCBVU0EuJiN4RDtEaXZpc2lvbiBvZiBUcmFuc3BsYW50YXRpb24gUGF0aG9sb2d5LCBUaG9tYXMg
RS4gU3RhcnpsIFRyYW5zcGxhbnRhdGlvbiBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgb2YgUGl0dHNi
dXJnaCwgUGl0dHNidXJnaCwgUEEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTGFib3JhdG9yeSBN
ZWRpY2luZSBhbmQgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IG9mIEFsYmVydGEsIEVkbW9udG9uLCBD
YW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIEJhbmZmIDIwMTcgS2lkbmV5
IE1lZXRpbmcgUmVwb3J0OiBSZXZpc2VkIERpYWdub3N0aWMgQ3JpdGVyaWEgZm9yIENocm9uaWMg
QWN0aXZlIFQgQ2VsbC1NZWRpYXRlZCBSZWplY3Rpb24sIEFudGlib2R5LU1lZGlhdGVkIFJlamVj
dGlvbiwgYW5kIFByb3NwZWN0cyBmb3IgSW50ZWdyYXRpdmUgRW5kcG9pbnRzIGZvciBOZXh0LUdl
bmVyYXRpb24gQ2xpbmljYWwgVHJpYWxzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFtIEogVHJh
bnNwbGFudDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl
PkFtIEogVHJhbnNwbGFudDwvZnVsbC10aXRsZT48YWJici0xPkFtZXJpY2FuIGpvdXJuYWwgb2Yg
dHJhbnNwbGFudGF0aW9uIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgQW1lcmljYW4gU29jaWV0
eSBvZiBUcmFuc3BsYW50YXRpb24gYW5kIHRoZSBBbWVyaWNhbiBTb2NpZXR5IG9mIFRyYW5zcGxh
bnQgU3VyZ2VvbnM8L2FiYnItMT48L3BlcmlvZGljYWw+PGVkaXRpb24+MjAxNy8xMi8xNjwvZWRp
dGlvbj48ZGF0ZXM+PHllYXI+MjAxNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYyAxNTwvZGF0
ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE2MDAtNjE0MyAoRWxlY3Ryb25pYykmI3hEOzE2
MDAtNjEzNSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjkyNDMzOTQ8L2FjY2Vzc2lv
bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5n
b3YvcHVibWVkLzI5MjQzMzk0PC91cmw+PHVybD5odHRwOi8vb25saW5lbGlicmFyeS53aWxleS5j
b20vc3RvcmUvMTAuMTExMS9hanQuMTQ2MjUvYXNzZXQvYWp0MTQ2MjUucGRmP3Y9MSZhbXA7dD1q
YzBlNnc1YSZhbXA7cz1kMWI2OTJiZGRiZDFkOTkwY2FjNDJhNjM2MDc1MmVjYTBjNWFkZTE1PC91
cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTEx
L2FqdC4xNDYyNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k
Tm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1)CortexThe outer part of the renal parenchyma, beneath the capsule and peripheral from the medulla, including the columns of Bertin. It is characterised by the presence of glomeruli and arteries. ADDIN EN.CITE <EndNote><Cite><Author>Bonsib</Author><Year>2015</Year><RecNum>9117</RecNum><DisplayText>(<style face="italic">6</style>)</DisplayText><record><rec-number>9117</rec-number><foreign-keys><key app="EN" db-id="90tpszswbfs2f3evsw8vz9a52vrp9e2xa95e" timestamp="0">9117</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Bonsib, S. M.</author></authors><secondary-authors><author>Jennette, C. J.</author><author>Silva, F. G.</author><author>Olson, J. L.</author><author>D'Agati, V. D.</author></secondary-authors></contributors><titles><title>Renal Anatomy and Histology</title><secondary-title>Heptinstall's Pathology of the Kidney</secondary-title></titles><pages>1-66</pages><volume>1</volume><num-vols>2</num-vols><section>1</section><dates><year>2015</year></dates><pub-location>Philadelphia, PA, USA</pub-location><publisher>Lippincot Williams & Wilkins</publisher><isbn>978-1-4511-4411-6</isbn><urls></urls></record></Cite></EndNote>(6)Donor-specific Antibody (DSA)Circulating antibodies directed against donor human leukocyte antigen (HLA) class I and/or class II and/or non-HLA antigens. For the definition and technical details see the recent and forthcoming consensus recommendations by The Transplantation Society.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYWl0PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYWl0PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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==
ADDIN EN.CITE.DATA (7) DSA are relevant for Banff Diagnostic Category 2 (AMR) diagnoses. For Active and Chronic Active AMR only DSA present at the approximate time of biopsy and against the current transplant are considered positive for the diagnosis; for Chronic AMR DSA against the current transplant present at or prior to the biopsy are considered.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1) Fibrointimal Thickening, ArterialSee Transplant Arteriopathy.Gene Transcripts/Classifiers in the Biopsy Tissue strongly associated with AMRIncreased expression of these, if thoroughly validated, are the only molecular markers considered in the Banff classification. Since Banff 2013PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (4) they have been included in Banff Diagnostic Category 2 for the diagnosis of Active AMR and Chronic Active AMR.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE.DATA (3) Along with C4d positivity, they are considered equivalent to positive test for DSA, although serological testing for DSA is still encouraged.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj
TnVtPjEwNzgyPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig8c3R5bGUgZmFjZT0iaXRhbGljIj4xPC9z
dHlsZT4pPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjEwNzgyPC9yZWMtbnVtYmVy
Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOTB0cHN6c3diZnMyZjNldnN3OHZ6
OWE1MnZycDllMnhhOTVlIiB0aW1lc3RhbXA9IjE1MTUwNjQzMzIiPjEwNzgyPC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYWFzLCBNLjwvYXV0aG9yPjxhdXRob3I+TG91
cHksIEEuPC9hdXRob3I+PGF1dGhvcj5MZWZhdWNoZXVyLCBDLjwvYXV0aG9yPjxhdXRob3I+Um91
Zm9zc2UsIEMuPC9hdXRob3I+PGF1dGhvcj5HbG90eiwgRC48L2F1dGhvcj48YXV0aG9yPlNlcm9u
LCBELjwvYXV0aG9yPjxhdXRob3I+TmFua2l2ZWxsLCBCLiBKLjwvYXV0aG9yPjxhdXRob3I+SGFs
bG9yYW4sIFAuIEYuPC9hdXRob3I+PGF1dGhvcj5Db2x2aW4sIFIuIEIuPC9hdXRob3I+PGF1dGhv
cj5BbGFjaGthciwgTi48L2F1dGhvcj48YXV0aG9yPkJhZ25hc2NvLCBTLjwvYXV0aG9yPjxhdXRo
b3I+Qm91YXRvdSwgWS48L2F1dGhvcj48YXV0aG9yPkJlY2tlciwgSi4gVS48L2F1dGhvcj48YXV0
aG9yPkNvcm5lbGwsIEwuPC9hdXRob3I+PGF1dGhvcj5EdW9uZyB2YW4gSHV5ZW4sIEouIFAuPC9h
dXRob3I+PGF1dGhvcj5HaWJzb24sIEkuPC9hdXRob3I+PGF1dGhvcj5NYW5ub24sIFIuPC9hdXRo
b3I+PGF1dGhvcj5OYWVzZW5zLCBNLjwvYXV0aG9yPjxhdXRob3I+Tmlja2VsZWl0LCBWLjwvYXV0
aG9yPjxhdXRob3I+Tmlja2Vyc29uLCBQLjwvYXV0aG9yPjxhdXRob3I+U2VnZXYsIEQuIEwuPC9h
dXRob3I+PGF1dGhvcj5TaW5naCwgSC4gSy48L2F1dGhvcj48YXV0aG9yPlN0ZWdhbGwsIE0uPC9h
dXRob3I+PGF1dGhvcj5SYW5kaGF3YSwgUC48L2F1dGhvcj48YXV0aG9yPlJhY3VzZW4sIEwuPC9h
dXRob3I+PGF1dGhvcj5Tb2xleiwgSy48L2F1dGhvcj48YXV0aG9yPk1lbmdlbCwgTS48L2F1dGhv
cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBh
dGhvbG9neSAmYW1wOyBMYWJvcmF0b3J5IE1lZGljaW5lLCBDZWRhcnMtU2luYWkgTWVkaWNhbCBD
ZW50ZXIsIExvcyBBbmdlbGVzLCBDQSwgVVNBLiYjeEQ7UGFyaXMgVHJhbnNsYXRpb25hbCBSZXNl
YXJjaCBDZW50ZXIgZm9yIG9yZ2FuIHRyYW5zcGxhbnRhdGlvbiBJTlNFUk0gVTk3MCAmYW1wOyBO
ZWNrZXIgSG9zcGl0YWwgVW5pdmVyc2l0eSBQYXJpcyBEZXNjYXJ0ZXMsIFBhcmlzLCBGcmFuY2Uu
JiN4RDtQYXJpcyBUcmFuc2xhdGlvbmFsIFJlc2VhcmNoIENlbnRlciBmb3Igb3JnYW4gdHJhbnNw
bGFudGF0aW9uICZhbXA7IERlcGFydG1lbnQgb2YgTmVwaHJvbG9neSBhbmQgVHJhbnNwbGFudGF0
aW9uLCBIb3BpdGFsIFNhaW50IExvdWlzLCBVbml2ZXJzaXRlIFBhcmlzIFZJSSBhbmQgSU5TRVJN
IFUgMTE2MCwgUGFyaXMsIEZyYW5jZS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUsIEltcGVy
aWFsIENvbGxlZ2UgTG9uZG9uIGFuZCBOb3J0aCBXZXN0IExvbmRvbiBQYXRob2xvZ3ksIExvbmRv
biwgVUsuJiN4RDtOZXBocm9sb2d5IERlcGFydG1lbnQsIEhvc3BpdGFsIFZhbGwgZCZhcG9zO0hl
YnJvbiwgQXV0b25vbW91cyBVbml2ZXJzaXR5IG9mIEJhcmNlbG9uYSwgU3BhaW4uJiN4RDtEZXB0
LiBvZiBSZW5hbCBNZWRpY2luZSwgV2VzdG1lYWQgSG9zcGl0YWwsIFN5ZG5leSwgQXVzdHJhbGlh
LiYjeEQ7QWxiZXJ0YSBUcmFuc3BsYW50IEFwcGxpZWQgR2Vub21pY3MgQ2VudHJlLCBVbml2ZXJz
aXR5IG9mIEFsYmVydGEsIEVkbW9udG9uLCBBbGJlcnRhLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50
IG9mIFBhdGhvbG9neSwgTWFzc2FjaHVzZXR0cyBHZW5lcmFsIEhvc3BpdGFsLCBIYXJ2YXJkIE1l
ZGljYWwgU2Nob29sLCBCb3N0b24sIE1BLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5l
LCBTZWN0aW9uIG9mIE5lcGhyb2xvZ3ksIEpvaG5zIEhvcGtpbnMgVW5pdmVyc2l0eSBTY2hvb2wg
b2YgTWVkaWNpbmUsIEJhbHRpbW9yZSwgTUQsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgUGF0aG9s
b2d5LCBKb2hucyBIb3BraW5zIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBCYWx0aW1v
cmUsIE1ELCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljYWwgU3BlY2lhbGl0aWVzLCBEaXZp
c2lvbiBvZiBOZXBocm9sb2d5LCBHZW5ldmEgVW5pdmVyc2l0eSBIb3NwaXRhbHMsIEdlbmV2YSwg
U3dpdHplcmxhbmQuJiN4RDtJbnN0aXR1dGUgb2YgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IEhvc3Bp
dGFsIG9mIENvbG9nbmUsIENvbG9nbmUsIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIExhYm9y
YXRvcnkgTWVkaWNpbmUgYW5kIFBhdGhvbG9neSwgTWF5byBDbGluaWMsIFJvY2hlc3RlciwgTU4s
IFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IG9mIE1hbml0b2Jh
LCBXaW5uaXBlZywgQ2FuYWRhLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgRGl2aXNpb24g
b2YgTmVwaHJvbG9neSwgVW5pdmVyc2l0eSBvZiBBbGFiYW1hIFNjaG9vbCBvZiBNZWRpY2luZSwg
QmlybWluZ2hhbSwgQUwsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTWljcm9iaW9sb2d5IGFuZCBJ
bW11bm9sb2d5LCBVbml2ZXJzaXR5IG9mIExldXZlbiAmYW1wOyBEZXBhcnRtZW50IG9mIE5lcGhy
b2xvZ3ksIFVuaXZlcnNpdHkgSG9zcGl0YWxzIExldXZlbiwgTGV1dmVuLCBCZWxnaXVtLiYjeEQ7
RGl2aXNpb24gb2YgTmVwaHJvcGF0aG9sb2d5LCBEZXBhcnRtZW50IG9mIFBhdGhvbG9neSBhbmQg
TGFib3JhdG9yeSBNZWRpY2luZSwgVGhlIFVuaXZlcnNpdHkgb2YgTm9ydGggQ2Fyb2xpbmEgU2No
b29sIG9mIE1lZGljaW5lLCBDaGFwZWwgSGlsbCwgTkMsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2Yg
SW50ZXJuYWwgTWVkaWNpbmUgYW5kIEltbXVub2xvZ3ksIFVuaXZlcnNpdHkgb2YgTWFuaXRvYmEs
IFdpbm5pcGVnLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50IG9mIFN1cmdlcnksIEpvaG5zIEhvcGtp
bnMgTWVkaWNhbCBJbnN0aXR1dGlvbnMsIEJhbHRpbW9yZSwgTUQsIFVTQS4mI3hEO0RlcGFydG1l
bnRzIG9mIFN1cmdlcnkgYW5kIEltbXVub2xvZ3ksIE1heW8gQ2xpbmljLCBSb2NoZXN0ZXIsIE1O
LCBVU0EuJiN4RDtEaXZpc2lvbiBvZiBUcmFuc3BsYW50YXRpb24gUGF0aG9sb2d5LCBUaG9tYXMg
RS4gU3RhcnpsIFRyYW5zcGxhbnRhdGlvbiBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgb2YgUGl0dHNi
dXJnaCwgUGl0dHNidXJnaCwgUEEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTGFib3JhdG9yeSBN
ZWRpY2luZSBhbmQgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IG9mIEFsYmVydGEsIEVkbW9udG9uLCBD
YW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIEJhbmZmIDIwMTcgS2lkbmV5
IE1lZXRpbmcgUmVwb3J0OiBSZXZpc2VkIERpYWdub3N0aWMgQ3JpdGVyaWEgZm9yIENocm9uaWMg
QWN0aXZlIFQgQ2VsbC1NZWRpYXRlZCBSZWplY3Rpb24sIEFudGlib2R5LU1lZGlhdGVkIFJlamVj
dGlvbiwgYW5kIFByb3NwZWN0cyBmb3IgSW50ZWdyYXRpdmUgRW5kcG9pbnRzIGZvciBOZXh0LUdl
bmVyYXRpb24gQ2xpbmljYWwgVHJpYWxzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFtIEogVHJh
bnNwbGFudDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl
PkFtIEogVHJhbnNwbGFudDwvZnVsbC10aXRsZT48YWJici0xPkFtZXJpY2FuIGpvdXJuYWwgb2Yg
dHJhbnNwbGFudGF0aW9uIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgQW1lcmljYW4gU29jaWV0
eSBvZiBUcmFuc3BsYW50YXRpb24gYW5kIHRoZSBBbWVyaWNhbiBTb2NpZXR5IG9mIFRyYW5zcGxh
bnQgU3VyZ2VvbnM8L2FiYnItMT48L3BlcmlvZGljYWw+PGVkaXRpb24+MjAxNy8xMi8xNjwvZWRp
dGlvbj48ZGF0ZXM+PHllYXI+MjAxNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYyAxNTwvZGF0
ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE2MDAtNjE0MyAoRWxlY3Ryb25pYykmI3hEOzE2
MDAtNjEzNSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjkyNDMzOTQ8L2FjY2Vzc2lv
bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5n
b3YvcHVibWVkLzI5MjQzMzk0PC91cmw+PHVybD5odHRwOi8vb25saW5lbGlicmFyeS53aWxleS5j
b20vc3RvcmUvMTAuMTExMS9hanQuMTQ2MjUvYXNzZXQvYWp0MTQ2MjUucGRmP3Y9MSZhbXA7dD1q
YzBlNnc1YSZhbXA7cz1kMWI2OTJiZGRiZDFkOTkwY2FjNDJhNjM2MDc1MmVjYTBjNWFkZTE1PC91
cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTEx
L2FqdC4xNDYyNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k
Tm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1)GlomerulonephritisRecurrent or de novo glomerulonephritis can occur in renal transplant biopsies. The diagnosis is made by a combination of conventional histology, immunohistochemistry or immunofluorescence, electron microscopy and correlation with clinical data. It should be diagnosed under Banff Diagnostic Category 6, and can be used in combination with categories 2-5 and any other diagnosis from Category 6. The presence of glomerulonephritis precludes the use of Banff Lesion Score g as histologic evidence of acute tissue injury for the diagnosis of Active AMR and of Banff Lesion Score cg as evidence of chronic tissue injury in the diagnosis of Chronic Active or Chronic AMR.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj
TnVtPjEwNzgyPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig8c3R5bGUgZmFjZT0iaXRhbGljIj4xPC9z
dHlsZT4pPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjEwNzgyPC9yZWMtbnVtYmVy
Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOTB0cHN6c3diZnMyZjNldnN3OHZ6
OWE1MnZycDllMnhhOTVlIiB0aW1lc3RhbXA9IjE1MTUwNjQzMzIiPjEwNzgyPC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYWFzLCBNLjwvYXV0aG9yPjxhdXRob3I+TG91
cHksIEEuPC9hdXRob3I+PGF1dGhvcj5MZWZhdWNoZXVyLCBDLjwvYXV0aG9yPjxhdXRob3I+Um91
Zm9zc2UsIEMuPC9hdXRob3I+PGF1dGhvcj5HbG90eiwgRC48L2F1dGhvcj48YXV0aG9yPlNlcm9u
LCBELjwvYXV0aG9yPjxhdXRob3I+TmFua2l2ZWxsLCBCLiBKLjwvYXV0aG9yPjxhdXRob3I+SGFs
bG9yYW4sIFAuIEYuPC9hdXRob3I+PGF1dGhvcj5Db2x2aW4sIFIuIEIuPC9hdXRob3I+PGF1dGhv
cj5BbGFjaGthciwgTi48L2F1dGhvcj48YXV0aG9yPkJhZ25hc2NvLCBTLjwvYXV0aG9yPjxhdXRo
b3I+Qm91YXRvdSwgWS48L2F1dGhvcj48YXV0aG9yPkJlY2tlciwgSi4gVS48L2F1dGhvcj48YXV0
aG9yPkNvcm5lbGwsIEwuPC9hdXRob3I+PGF1dGhvcj5EdW9uZyB2YW4gSHV5ZW4sIEouIFAuPC9h
dXRob3I+PGF1dGhvcj5HaWJzb24sIEkuPC9hdXRob3I+PGF1dGhvcj5NYW5ub24sIFIuPC9hdXRo
b3I+PGF1dGhvcj5OYWVzZW5zLCBNLjwvYXV0aG9yPjxhdXRob3I+Tmlja2VsZWl0LCBWLjwvYXV0
aG9yPjxhdXRob3I+Tmlja2Vyc29uLCBQLjwvYXV0aG9yPjxhdXRob3I+U2VnZXYsIEQuIEwuPC9h
dXRob3I+PGF1dGhvcj5TaW5naCwgSC4gSy48L2F1dGhvcj48YXV0aG9yPlN0ZWdhbGwsIE0uPC9h
dXRob3I+PGF1dGhvcj5SYW5kaGF3YSwgUC48L2F1dGhvcj48YXV0aG9yPlJhY3VzZW4sIEwuPC9h
dXRob3I+PGF1dGhvcj5Tb2xleiwgSy48L2F1dGhvcj48YXV0aG9yPk1lbmdlbCwgTS48L2F1dGhv
cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBh
dGhvbG9neSAmYW1wOyBMYWJvcmF0b3J5IE1lZGljaW5lLCBDZWRhcnMtU2luYWkgTWVkaWNhbCBD
ZW50ZXIsIExvcyBBbmdlbGVzLCBDQSwgVVNBLiYjeEQ7UGFyaXMgVHJhbnNsYXRpb25hbCBSZXNl
YXJjaCBDZW50ZXIgZm9yIG9yZ2FuIHRyYW5zcGxhbnRhdGlvbiBJTlNFUk0gVTk3MCAmYW1wOyBO
ZWNrZXIgSG9zcGl0YWwgVW5pdmVyc2l0eSBQYXJpcyBEZXNjYXJ0ZXMsIFBhcmlzLCBGcmFuY2Uu
JiN4RDtQYXJpcyBUcmFuc2xhdGlvbmFsIFJlc2VhcmNoIENlbnRlciBmb3Igb3JnYW4gdHJhbnNw
bGFudGF0aW9uICZhbXA7IERlcGFydG1lbnQgb2YgTmVwaHJvbG9neSBhbmQgVHJhbnNwbGFudGF0
aW9uLCBIb3BpdGFsIFNhaW50IExvdWlzLCBVbml2ZXJzaXRlIFBhcmlzIFZJSSBhbmQgSU5TRVJN
IFUgMTE2MCwgUGFyaXMsIEZyYW5jZS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUsIEltcGVy
aWFsIENvbGxlZ2UgTG9uZG9uIGFuZCBOb3J0aCBXZXN0IExvbmRvbiBQYXRob2xvZ3ksIExvbmRv
biwgVUsuJiN4RDtOZXBocm9sb2d5IERlcGFydG1lbnQsIEhvc3BpdGFsIFZhbGwgZCZhcG9zO0hl
YnJvbiwgQXV0b25vbW91cyBVbml2ZXJzaXR5IG9mIEJhcmNlbG9uYSwgU3BhaW4uJiN4RDtEZXB0
LiBvZiBSZW5hbCBNZWRpY2luZSwgV2VzdG1lYWQgSG9zcGl0YWwsIFN5ZG5leSwgQXVzdHJhbGlh
LiYjeEQ7QWxiZXJ0YSBUcmFuc3BsYW50IEFwcGxpZWQgR2Vub21pY3MgQ2VudHJlLCBVbml2ZXJz
aXR5IG9mIEFsYmVydGEsIEVkbW9udG9uLCBBbGJlcnRhLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50
IG9mIFBhdGhvbG9neSwgTWFzc2FjaHVzZXR0cyBHZW5lcmFsIEhvc3BpdGFsLCBIYXJ2YXJkIE1l
ZGljYWwgU2Nob29sLCBCb3N0b24sIE1BLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5l
LCBTZWN0aW9uIG9mIE5lcGhyb2xvZ3ksIEpvaG5zIEhvcGtpbnMgVW5pdmVyc2l0eSBTY2hvb2wg
b2YgTWVkaWNpbmUsIEJhbHRpbW9yZSwgTUQsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgUGF0aG9s
b2d5LCBKb2hucyBIb3BraW5zIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBCYWx0aW1v
cmUsIE1ELCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljYWwgU3BlY2lhbGl0aWVzLCBEaXZp
c2lvbiBvZiBOZXBocm9sb2d5LCBHZW5ldmEgVW5pdmVyc2l0eSBIb3NwaXRhbHMsIEdlbmV2YSwg
U3dpdHplcmxhbmQuJiN4RDtJbnN0aXR1dGUgb2YgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IEhvc3Bp
dGFsIG9mIENvbG9nbmUsIENvbG9nbmUsIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIExhYm9y
YXRvcnkgTWVkaWNpbmUgYW5kIFBhdGhvbG9neSwgTWF5byBDbGluaWMsIFJvY2hlc3RlciwgTU4s
IFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IG9mIE1hbml0b2Jh
LCBXaW5uaXBlZywgQ2FuYWRhLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgRGl2aXNpb24g
b2YgTmVwaHJvbG9neSwgVW5pdmVyc2l0eSBvZiBBbGFiYW1hIFNjaG9vbCBvZiBNZWRpY2luZSwg
QmlybWluZ2hhbSwgQUwsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTWljcm9iaW9sb2d5IGFuZCBJ
bW11bm9sb2d5LCBVbml2ZXJzaXR5IG9mIExldXZlbiAmYW1wOyBEZXBhcnRtZW50IG9mIE5lcGhy
b2xvZ3ksIFVuaXZlcnNpdHkgSG9zcGl0YWxzIExldXZlbiwgTGV1dmVuLCBCZWxnaXVtLiYjeEQ7
RGl2aXNpb24gb2YgTmVwaHJvcGF0aG9sb2d5LCBEZXBhcnRtZW50IG9mIFBhdGhvbG9neSBhbmQg
TGFib3JhdG9yeSBNZWRpY2luZSwgVGhlIFVuaXZlcnNpdHkgb2YgTm9ydGggQ2Fyb2xpbmEgU2No
b29sIG9mIE1lZGljaW5lLCBDaGFwZWwgSGlsbCwgTkMsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2Yg
SW50ZXJuYWwgTWVkaWNpbmUgYW5kIEltbXVub2xvZ3ksIFVuaXZlcnNpdHkgb2YgTWFuaXRvYmEs
IFdpbm5pcGVnLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50IG9mIFN1cmdlcnksIEpvaG5zIEhvcGtp
bnMgTWVkaWNhbCBJbnN0aXR1dGlvbnMsIEJhbHRpbW9yZSwgTUQsIFVTQS4mI3hEO0RlcGFydG1l
bnRzIG9mIFN1cmdlcnkgYW5kIEltbXVub2xvZ3ksIE1heW8gQ2xpbmljLCBSb2NoZXN0ZXIsIE1O
LCBVU0EuJiN4RDtEaXZpc2lvbiBvZiBUcmFuc3BsYW50YXRpb24gUGF0aG9sb2d5LCBUaG9tYXMg
RS4gU3RhcnpsIFRyYW5zcGxhbnRhdGlvbiBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgb2YgUGl0dHNi
dXJnaCwgUGl0dHNidXJnaCwgUEEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTGFib3JhdG9yeSBN
ZWRpY2luZSBhbmQgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IG9mIEFsYmVydGEsIEVkbW9udG9uLCBD
YW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIEJhbmZmIDIwMTcgS2lkbmV5
IE1lZXRpbmcgUmVwb3J0OiBSZXZpc2VkIERpYWdub3N0aWMgQ3JpdGVyaWEgZm9yIENocm9uaWMg
QWN0aXZlIFQgQ2VsbC1NZWRpYXRlZCBSZWplY3Rpb24sIEFudGlib2R5LU1lZGlhdGVkIFJlamVj
dGlvbiwgYW5kIFByb3NwZWN0cyBmb3IgSW50ZWdyYXRpdmUgRW5kcG9pbnRzIGZvciBOZXh0LUdl
bmVyYXRpb24gQ2xpbmljYWwgVHJpYWxzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFtIEogVHJh
bnNwbGFudDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl
PkFtIEogVHJhbnNwbGFudDwvZnVsbC10aXRsZT48YWJici0xPkFtZXJpY2FuIGpvdXJuYWwgb2Yg
dHJhbnNwbGFudGF0aW9uIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgQW1lcmljYW4gU29jaWV0
eSBvZiBUcmFuc3BsYW50YXRpb24gYW5kIHRoZSBBbWVyaWNhbiBTb2NpZXR5IG9mIFRyYW5zcGxh
bnQgU3VyZ2VvbnM8L2FiYnItMT48L3BlcmlvZGljYWw+PGVkaXRpb24+MjAxNy8xMi8xNjwvZWRp
dGlvbj48ZGF0ZXM+PHllYXI+MjAxNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYyAxNTwvZGF0
ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE2MDAtNjE0MyAoRWxlY3Ryb25pYykmI3hEOzE2
MDAtNjEzNSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjkyNDMzOTQ8L2FjY2Vzc2lv
bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5n
b3YvcHVibWVkLzI5MjQzMzk0PC91cmw+PHVybD5odHRwOi8vb25saW5lbGlicmFyeS53aWxleS5j
b20vc3RvcmUvMTAuMTExMS9hanQuMTQ2MjUvYXNzZXQvYWp0MTQ2MjUucGRmP3Y9MSZhbXA7dD1q
YzBlNnc1YSZhbXA7cz1kMWI2OTJiZGRiZDFkOTkwY2FjNDJhNjM2MDc1MmVjYTBjNWFkZTE1PC91
cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTEx
L2FqdC4xNDYyNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k
Tm90ZT5=
ADDIN EN.CITE.DATA (1)Haemorrhage, TubulointerstitialExtravasation of red blood cells into the tubulointerstitium. There is no special Banff Lesion Score for this lesion. Instead the lesion is noted as an asterisk “*” attached to Banff Lesion Score v (e.g. v0* or v3*). It shares this coding with Infarct.InfarctZone of tissue which is non-viable due to insufficient blood supply. It qualifies as “necrosis” listed in the supplement of Banff 2015 and since Banff 1997 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWN1c2VuPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWN1c2VuPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48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ADDIN EN.CITE.DATA (2) has been coded with an asterisk (*) behind the Banff Lesion Score v (e.g. v1*, v2*) accordingly.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE.DATA (3) Infarcted areas must not be scored for Banff Lesion Score C4d.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tb2xlejwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl
Y051bT4xNjc3PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig8c3R5bGUgZmFjZT0iaXRhbGljIj44PC9z
dHlsZT4pPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjE2Nzc8L3JlYy1udW1iZXI+
PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI5MHRwc3pzd2JmczJmM2V2c3c4dno5
YTUydnJwOWUyeGE5NWUiIHRpbWVzdGFtcD0iMCI+MTY3Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxy
ZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3Jz
PjxhdXRob3JzPjxhdXRob3I+U29sZXosIEsuPC9hdXRob3I+PGF1dGhvcj5Db2x2aW4sIFIuIEIu
PC9hdXRob3I+PGF1dGhvcj5SYWN1c2VuLCBMLiBDLjwvYXV0aG9yPjxhdXRob3I+SGFhcywgTS48
L2F1dGhvcj48YXV0aG9yPlNpcywgQi48L2F1dGhvcj48YXV0aG9yPk1lbmdlbCwgTS48L2F1dGhv
cj48YXV0aG9yPkhhbGxvcmFuLCBQLiBGLjwvYXV0aG9yPjxhdXRob3I+QmFsZHdpbiwgVy48L2F1
dGhvcj48YXV0aG9yPkJhbmZpLCBHLjwvYXV0aG9yPjxhdXRob3I+Q29sbGlucywgQS4gQi48L2F1
dGhvcj48YXV0aG9yPkNvc2lvLCBGLjwvYXV0aG9yPjxhdXRob3I+RGF2aWQsIEQuIFMuPC9hdXRo
b3I+PGF1dGhvcj5EcmFjaGVuYmVyZywgQy48L2F1dGhvcj48YXV0aG9yPkVpbmVja2UsIEcuPC9h
dXRob3I+PGF1dGhvcj5Gb2dvLCBBLiBCLjwvYXV0aG9yPjxhdXRob3I+R2lic29uLCBJLiBXLjwv
YXV0aG9yPjxhdXRob3I+R2xvdHosIEQuPC9hdXRob3I+PGF1dGhvcj5Jc2thbmRhciwgUy4gUy48
L2F1dGhvcj48YXV0aG9yPktyYXVzLCBFLjwvYXV0aG9yPjxhdXRob3I+TGVydXQsIEUuPC9hdXRo
b3I+PGF1dGhvcj5NYW5ub24sIFIuIEIuPC9hdXRob3I+PGF1dGhvcj5NaWhhdHNjaCwgTS48L2F1
dGhvcj48YXV0aG9yPk5hbmtpdmVsbCwgQi4gSi48L2F1dGhvcj48YXV0aG9yPk5pY2tlbGVpdCwg
Vi48L2F1dGhvcj48YXV0aG9yPlBhcGFkaW1pdHJpb3UsIEouIEMuPC9hdXRob3I+PGF1dGhvcj5S
YW5kaGF3YSwgUC48L2F1dGhvcj48YXV0aG9yPlJlZ2VsZSwgSC48L2F1dGhvcj48YXV0aG9yPlJl
bmF1ZGluLCBLLjwvYXV0aG9yPjxhdXRob3I+Um9iZXJ0cywgSS48L2F1dGhvcj48YXV0aG9yPlNl
cm9uLCBELjwvYXV0aG9yPjxhdXRob3I+U21pdGgsIFIuIE4uPC9hdXRob3I+PGF1dGhvcj5WYWxl
bnRlLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRl
cGFydG1lbnQgb2YgTGFib3JhdG9yeSBNZWRpY2luZSBhbmQgUGF0aG9sb2d5LCBVbml2ZXJzaXR5
IG9mIEFsYmVydGEsIEVkbW9udG9uLCBDYW5hZGEuIEtpbS5Tb2xlekB1YWxiZXJ0YS5jYTwvYXV0
aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkJhbmZmIDA3IGNsYXNzaWZpY2F0aW9uIG9mIHJlbmFs
IGFsbG9ncmFmdCBwYXRob2xvZ3k6IHVwZGF0ZXMgYW5kIGZ1dHVyZSBkaXJlY3Rpb25zPC90aXRs
ZT48c2Vjb25kYXJ5LXRpdGxlPkFtIEogVHJhbnNwbGFudDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0
bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtIEogVHJhbnNwbGFudDwvZnVsbC10aXRsZT48
YWJici0xPkFtZXJpY2FuIGpvdXJuYWwgb2YgdHJhbnNwbGFudGF0aW9uIDogb2ZmaWNpYWwgam91
cm5hbCBvZiB0aGUgQW1lcmljYW4gU29jaWV0eSBvZiBUcmFuc3BsYW50YXRpb24gYW5kIHRoZSBB
bWVyaWNhbiBTb2NpZXR5IG9mIFRyYW5zcGxhbnQgU3VyZ2VvbnM8L2FiYnItMT48L3BlcmlvZGlj
YWw+PHBhZ2VzPjc1My02MDwvcGFnZXM+PHZvbHVtZT44PC92b2x1bWU+PG51bWJlcj40PC9udW1i
ZXI+PGVkaXRpb24+MjAwOC8wMi8yNjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QmlvcHN5
PC9rZXl3b3JkPjxrZXl3b3JkPkNsaW5pY2FsIFRyaWFscyBhcyBUb3BpYzwva2V5d29yZD48a2V5
d29yZD5Db21wbGVtZW50IEM0Yi9hbmFseXNpczwva2V5d29yZD48a2V5d29yZD5HcmFmdCBSZWpl
Y3Rpb24vcGF0aG9sb2d5L3ByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5d29yZD48a2V5d29y
ZD5HcmFmdCBTdXJ2aXZhbDwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv
cmQ+SW1tdW5vc3VwcHJlc3NpdmUgQWdlbnRzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5
d29yZD5LaWRuZXkgVHJhbnNwbGFudGF0aW9uL2ltbXVub2xvZ3kvKnBhdGhvbG9neTwva2V5d29y
ZD48a2V5d29yZD5QZXB0aWRlIEZyYWdtZW50cy9hbmFseXNpczwva2V5d29yZD48a2V5d29yZD5U
cmFuc3BsYW50YXRpb24sIEhvbW9sb2dvdXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHll
YXI+MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkFwcjwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh
dGVzPjxpc2JuPjE2MDAtNjE0MyAoRWxlY3Ryb25pYykmI3hEOzE2MDAtNjE0MyAoTGlua2luZyk8
L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTgyOTQzNDU8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0
ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9lbnRyZXovcXVlcnkuZmNn
aT9jbWQ9UmV0cmlldmUmYW1wO2RiPVB1Yk1lZCZhbXA7ZG9wdD1DaXRhdGlvbiZhbXA7bGlzdF91
aWRzPTE4Mjk0MzQ1PC91cmw+PHVybD5odHRwOi8vb25saW5lbGlicmFyeS53aWxleS5jb20vc3Rv
cmUvMTAuMTExMS9qLjE2MDAtNjE0My4yMDA4LjAyMTU5LngvYXNzZXQvai4xNjAwLTYxNDMuMjAw
OC4wMjE1OS54LnBkZj92PTEmYW1wO3Q9Z3loMWg5dW8mYW1wO3M9NzE1ODYwNTA0NWMyZjkwMzBm
NjVjMDRjZWNkMjBhNjE0OGM4ZDUxOTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry
b25pYy1yZXNvdXJjZS1udW0+QUpUMjE1OSBbcGlpXSYjeEQ7MTAuMTExMS9qLjE2MDAtNjE0My4y
MDA4LjAyMTU5Lng8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1
YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tb2xlejwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE.DATA (8)InfectionIn the presence of Infection (Table 5, Banff 2017) Banff Lesion Score g>0 greater is required when using moderate microvascular inflammation (sum of Banff g+ptc≥2) as a criterion from Criteria Group 3 (antibody interaction with tissue) for a diagnosis of Active AMR or Chronic Active AMR.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj
TnVtPjEwNzgyPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig8c3R5bGUgZmFjZT0iaXRhbGljIj4xPC9z
dHlsZT4pPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjEwNzgyPC9yZWMtbnVtYmVy
Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOTB0cHN6c3diZnMyZjNldnN3OHZ6
OWE1MnZycDllMnhhOTVlIiB0aW1lc3RhbXA9IjE1MTUwNjQzMzIiPjEwNzgyPC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYWFzLCBNLjwvYXV0aG9yPjxhdXRob3I+TG91
cHksIEEuPC9hdXRob3I+PGF1dGhvcj5MZWZhdWNoZXVyLCBDLjwvYXV0aG9yPjxhdXRob3I+Um91
Zm9zc2UsIEMuPC9hdXRob3I+PGF1dGhvcj5HbG90eiwgRC48L2F1dGhvcj48YXV0aG9yPlNlcm9u
LCBELjwvYXV0aG9yPjxhdXRob3I+TmFua2l2ZWxsLCBCLiBKLjwvYXV0aG9yPjxhdXRob3I+SGFs
bG9yYW4sIFAuIEYuPC9hdXRob3I+PGF1dGhvcj5Db2x2aW4sIFIuIEIuPC9hdXRob3I+PGF1dGhv
cj5BbGFjaGthciwgTi48L2F1dGhvcj48YXV0aG9yPkJhZ25hc2NvLCBTLjwvYXV0aG9yPjxhdXRo
b3I+Qm91YXRvdSwgWS48L2F1dGhvcj48YXV0aG9yPkJlY2tlciwgSi4gVS48L2F1dGhvcj48YXV0
aG9yPkNvcm5lbGwsIEwuPC9hdXRob3I+PGF1dGhvcj5EdW9uZyB2YW4gSHV5ZW4sIEouIFAuPC9h
dXRob3I+PGF1dGhvcj5HaWJzb24sIEkuPC9hdXRob3I+PGF1dGhvcj5NYW5ub24sIFIuPC9hdXRo
b3I+PGF1dGhvcj5OYWVzZW5zLCBNLjwvYXV0aG9yPjxhdXRob3I+Tmlja2VsZWl0LCBWLjwvYXV0
aG9yPjxhdXRob3I+Tmlja2Vyc29uLCBQLjwvYXV0aG9yPjxhdXRob3I+U2VnZXYsIEQuIEwuPC9h
dXRob3I+PGF1dGhvcj5TaW5naCwgSC4gSy48L2F1dGhvcj48YXV0aG9yPlN0ZWdhbGwsIE0uPC9h
dXRob3I+PGF1dGhvcj5SYW5kaGF3YSwgUC48L2F1dGhvcj48YXV0aG9yPlJhY3VzZW4sIEwuPC9h
dXRob3I+PGF1dGhvcj5Tb2xleiwgSy48L2F1dGhvcj48YXV0aG9yPk1lbmdlbCwgTS48L2F1dGhv
cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBh
dGhvbG9neSAmYW1wOyBMYWJvcmF0b3J5IE1lZGljaW5lLCBDZWRhcnMtU2luYWkgTWVkaWNhbCBD
ZW50ZXIsIExvcyBBbmdlbGVzLCBDQSwgVVNBLiYjeEQ7UGFyaXMgVHJhbnNsYXRpb25hbCBSZXNl
YXJjaCBDZW50ZXIgZm9yIG9yZ2FuIHRyYW5zcGxhbnRhdGlvbiBJTlNFUk0gVTk3MCAmYW1wOyBO
ZWNrZXIgSG9zcGl0YWwgVW5pdmVyc2l0eSBQYXJpcyBEZXNjYXJ0ZXMsIFBhcmlzLCBGcmFuY2Uu
JiN4RDtQYXJpcyBUcmFuc2xhdGlvbmFsIFJlc2VhcmNoIENlbnRlciBmb3Igb3JnYW4gdHJhbnNw
bGFudGF0aW9uICZhbXA7IERlcGFydG1lbnQgb2YgTmVwaHJvbG9neSBhbmQgVHJhbnNwbGFudGF0
aW9uLCBIb3BpdGFsIFNhaW50IExvdWlzLCBVbml2ZXJzaXRlIFBhcmlzIFZJSSBhbmQgSU5TRVJN
IFUgMTE2MCwgUGFyaXMsIEZyYW5jZS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUsIEltcGVy
aWFsIENvbGxlZ2UgTG9uZG9uIGFuZCBOb3J0aCBXZXN0IExvbmRvbiBQYXRob2xvZ3ksIExvbmRv
biwgVUsuJiN4RDtOZXBocm9sb2d5IERlcGFydG1lbnQsIEhvc3BpdGFsIFZhbGwgZCZhcG9zO0hl
YnJvbiwgQXV0b25vbW91cyBVbml2ZXJzaXR5IG9mIEJhcmNlbG9uYSwgU3BhaW4uJiN4RDtEZXB0
LiBvZiBSZW5hbCBNZWRpY2luZSwgV2VzdG1lYWQgSG9zcGl0YWwsIFN5ZG5leSwgQXVzdHJhbGlh
LiYjeEQ7QWxiZXJ0YSBUcmFuc3BsYW50IEFwcGxpZWQgR2Vub21pY3MgQ2VudHJlLCBVbml2ZXJz
aXR5IG9mIEFsYmVydGEsIEVkbW9udG9uLCBBbGJlcnRhLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50
IG9mIFBhdGhvbG9neSwgTWFzc2FjaHVzZXR0cyBHZW5lcmFsIEhvc3BpdGFsLCBIYXJ2YXJkIE1l
ZGljYWwgU2Nob29sLCBCb3N0b24sIE1BLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5l
LCBTZWN0aW9uIG9mIE5lcGhyb2xvZ3ksIEpvaG5zIEhvcGtpbnMgVW5pdmVyc2l0eSBTY2hvb2wg
b2YgTWVkaWNpbmUsIEJhbHRpbW9yZSwgTUQsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgUGF0aG9s
b2d5LCBKb2hucyBIb3BraW5zIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBCYWx0aW1v
cmUsIE1ELCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljYWwgU3BlY2lhbGl0aWVzLCBEaXZp
c2lvbiBvZiBOZXBocm9sb2d5LCBHZW5ldmEgVW5pdmVyc2l0eSBIb3NwaXRhbHMsIEdlbmV2YSwg
U3dpdHplcmxhbmQuJiN4RDtJbnN0aXR1dGUgb2YgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IEhvc3Bp
dGFsIG9mIENvbG9nbmUsIENvbG9nbmUsIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIExhYm9y
YXRvcnkgTWVkaWNpbmUgYW5kIFBhdGhvbG9neSwgTWF5byBDbGluaWMsIFJvY2hlc3RlciwgTU4s
IFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IG9mIE1hbml0b2Jh
LCBXaW5uaXBlZywgQ2FuYWRhLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgRGl2aXNpb24g
b2YgTmVwaHJvbG9neSwgVW5pdmVyc2l0eSBvZiBBbGFiYW1hIFNjaG9vbCBvZiBNZWRpY2luZSwg
QmlybWluZ2hhbSwgQUwsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTWljcm9iaW9sb2d5IGFuZCBJ
bW11bm9sb2d5LCBVbml2ZXJzaXR5IG9mIExldXZlbiAmYW1wOyBEZXBhcnRtZW50IG9mIE5lcGhy
b2xvZ3ksIFVuaXZlcnNpdHkgSG9zcGl0YWxzIExldXZlbiwgTGV1dmVuLCBCZWxnaXVtLiYjeEQ7
RGl2aXNpb24gb2YgTmVwaHJvcGF0aG9sb2d5LCBEZXBhcnRtZW50IG9mIFBhdGhvbG9neSBhbmQg
TGFib3JhdG9yeSBNZWRpY2luZSwgVGhlIFVuaXZlcnNpdHkgb2YgTm9ydGggQ2Fyb2xpbmEgU2No
b29sIG9mIE1lZGljaW5lLCBDaGFwZWwgSGlsbCwgTkMsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2Yg
SW50ZXJuYWwgTWVkaWNpbmUgYW5kIEltbXVub2xvZ3ksIFVuaXZlcnNpdHkgb2YgTWFuaXRvYmEs
IFdpbm5pcGVnLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50IG9mIFN1cmdlcnksIEpvaG5zIEhvcGtp
bnMgTWVkaWNhbCBJbnN0aXR1dGlvbnMsIEJhbHRpbW9yZSwgTUQsIFVTQS4mI3hEO0RlcGFydG1l
bnRzIG9mIFN1cmdlcnkgYW5kIEltbXVub2xvZ3ksIE1heW8gQ2xpbmljLCBSb2NoZXN0ZXIsIE1O
LCBVU0EuJiN4RDtEaXZpc2lvbiBvZiBUcmFuc3BsYW50YXRpb24gUGF0aG9sb2d5LCBUaG9tYXMg
RS4gU3RhcnpsIFRyYW5zcGxhbnRhdGlvbiBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgb2YgUGl0dHNi
dXJnaCwgUGl0dHNidXJnaCwgUEEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTGFib3JhdG9yeSBN
ZWRpY2luZSBhbmQgUGF0aG9sb2d5LCBVbml2ZXJzaXR5IG9mIEFsYmVydGEsIEVkbW9udG9uLCBD
YW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIEJhbmZmIDIwMTcgS2lkbmV5
IE1lZXRpbmcgUmVwb3J0OiBSZXZpc2VkIERpYWdub3N0aWMgQ3JpdGVyaWEgZm9yIENocm9uaWMg
QWN0aXZlIFQgQ2VsbC1NZWRpYXRlZCBSZWplY3Rpb24sIEFudGlib2R5LU1lZGlhdGVkIFJlamVj
dGlvbiwgYW5kIFByb3NwZWN0cyBmb3IgSW50ZWdyYXRpdmUgRW5kcG9pbnRzIGZvciBOZXh0LUdl
bmVyYXRpb24gQ2xpbmljYWwgVHJpYWxzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFtIEogVHJh
bnNwbGFudDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl
PkFtIEogVHJhbnNwbGFudDwvZnVsbC10aXRsZT48YWJici0xPkFtZXJpY2FuIGpvdXJuYWwgb2Yg
dHJhbnNwbGFudGF0aW9uIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgQW1lcmljYW4gU29jaWV0
eSBvZiBUcmFuc3BsYW50YXRpb24gYW5kIHRoZSBBbWVyaWNhbiBTb2NpZXR5IG9mIFRyYW5zcGxh
bnQgU3VyZ2VvbnM8L2FiYnItMT48L3BlcmlvZGljYWw+PGVkaXRpb24+MjAxNy8xMi8xNjwvZWRp
dGlvbj48ZGF0ZXM+PHllYXI+MjAxNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYyAxNTwvZGF0
ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE2MDAtNjE0MyAoRWxlY3Ryb25pYykmI3hEOzE2
MDAtNjEzNSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjkyNDMzOTQ8L2FjY2Vzc2lv
bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5n
b3YvcHVibWVkLzI5MjQzMzk0PC91cmw+PHVybD5odHRwOi8vb25saW5lbGlicmFyeS53aWxleS5j
b20vc3RvcmUvMTAuMTExMS9hanQuMTQ2MjUvYXNzZXQvYWp0MTQ2MjUucGRmP3Y9MSZhbXA7dD1q
YzBlNnc1YSZhbXA7cz1kMWI2OTJiZGRiZDFkOTkwY2FjNDJhNjM2MDc1MmVjYTBjNWFkZTE1PC91
cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTEx
L2FqdC4xNDYyNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k
Tm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1) I.e. Banff Lesion Score ptc2 with Banff Lesion Score g0 is insufficient for this criterion when disease caused by infection of the transplant is present.Interstitial fibrosisBanff Lesion Score ci for interstitial fibrosis was initially meant to describe the area fraction of fibrous tissue in the cortex only regardless of whether it represented fibrous tissue as the normal constituent of the renal cortex (considered to be 5%) or fibrous tissue within a cortical scar. Hence, a precise definition for individual patches of interstitial fibrosis in a scar has never been given. This purely morphometric approach runs counterintuitive to routine histopathological assessment for atrophic tubules separated by interstitial fibrosis in a tubulointerstitial scar. Guides for the assessment of Banff Lesion Score ci can be found in the main body of this manuscript.Microvascular Inflammation, ModerateMicrovascular inflammation is scored by calculating the sum of the two Banff Lesion Scores g and ptc. Microvascular inflammation is considered moderate with Banff Lesion Scores g + ptc ≥2. In the presence of Acute TCMR, Borderline Changes or Infection such as Pyelonephritis, Banff Lesion Score g must be equal or greater than 1 in this calculation to fulfil the criteria for moderate microvascular inflammation.Peritubular CapillaryOnly capillaries within the renal cortex are peritubular capillaries (PTCs) which can be used for scoring peritubular capillaritis as in Banff Lesion Score ptc. Capillaries next to lymphoid follicles must be disregarded to avoid confusion with lymphatic vessels. Banff Lesion Score C4d can be scored not only in PTCs but also in medullary vasa recta.Peritubular Capillary Basement Membrane MultilayeringSevere Peritubular Capillary Basement Membrane Multilayering (PTCML) is defined as “seven or more layers of basement membrane in one cortical peritubular capillary and five or more in two additional capillaries, avoiding portions cut tangentially“.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1) Only Severe Peritubular Capillary Basement Membrane Multilayering is considered sufficient as one possible criterion for chronicity of AMR. This relative high threshold has been established because mild PTCML can be seen in other diseases like hypertension. In cases where electron microscopy (EM) is carried out in transplant biopsies, cortical peritubular capillary multilayering should be assessed and reported. The number of layers of basement membrane should be counted in the most affected PTC as well as in at least two additional PTCs. Tangentially cut PTC should be avoided. See also recommendations for performing EM cited from the Banff 2015 report under Banff Lesion Score cg for more detail.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl
Y051bT45MDU3PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig8c3R5bGUgZmFjZT0iaXRhbGljIj4zPC9z
dHlsZT4pPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjkwNTc8L3JlYy1udW1iZXI+
PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI5MHRwc3pzd2JmczJmM2V2c3c4dno5
YTUydnJwOWUyeGE5NWUiIHRpbWVzdGFtcD0iMCI+OTA1Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxy
ZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3Jz
PjxhdXRob3JzPjxhdXRob3I+TG91cHksIEEuPC9hdXRob3I+PGF1dGhvcj5IYWFzLCBNLjwvYXV0
aG9yPjxhdXRob3I+U29sZXosIEsuPC9hdXRob3I+PGF1dGhvcj5SYWN1c2VuLCBMLjwvYXV0aG9y
PjxhdXRob3I+R2xvdHosIEQuPC9hdXRob3I+PGF1dGhvcj5TZXJvbiwgRC48L2F1dGhvcj48YXV0
aG9yPk5hbmtpdmVsbCwgQi4gSi48L2F1dGhvcj48YXV0aG9yPkNvbHZpbiwgUi4gQi48L2F1dGhv
cj48YXV0aG9yPkFmcm91emlhbiwgTS48L2F1dGhvcj48YXV0aG9yPkFrYWxpbiwgRS48L2F1dGhv
cj48YXV0aG9yPkFsYWNoa2FyLCBOLjwvYXV0aG9yPjxhdXRob3I+QmFnbmFzY28sIFMuPC9hdXRo
b3I+PGF1dGhvcj5CZWNrZXIsIEouIFUuPC9hdXRob3I+PGF1dGhvcj5Db3JuZWxsLCBMLjwvYXV0
aG9yPjxhdXRob3I+RHJhY2hlbmJlcmcsIEMuPC9hdXRob3I+PGF1dGhvcj5EcmFndW4sIEQuPC9h
dXRob3I+PGF1dGhvcj5EZSBLb3J0LCBILjwvYXV0aG9yPjxhdXRob3I+R2lic29uLCBJLiBXLjwv
YXV0aG9yPjxhdXRob3I+S3JhdXMsIEUuIFMuPC9hdXRob3I+PGF1dGhvcj5MZWZhdWNoZXVyLCBD
LjwvYXV0aG9yPjxhdXRob3I+TGVnZW5kcmUsIEMuPC9hdXRob3I+PGF1dGhvcj5MaWFwaXMsIEgu
PC9hdXRob3I+PGF1dGhvcj5NdXRodWt1bWFyLCBULjwvYXV0aG9yPjxhdXRob3I+Tmlja2VsZWl0
LCBWLjwvYXV0aG9yPjxhdXRob3I+T3JhbmRpLCBCLjwvYXV0aG9yPjxhdXRob3I+UGFyaywgVy48
L2F1dGhvcj48YXV0aG9yPlJhYmFudCwgTS48L2F1dGhvcj48YXV0aG9yPlJhbmRoYXdhLCBQLjwv
YXV0aG9yPjxhdXRob3I+UmVlZCwgRS4gRi48L2F1dGhvcj48YXV0aG9yPlJvdWZvc3NlLCBDLjwv
YXV0aG9yPjxhdXRob3I+U2VzaGFuLCBTLiBWLjwvYXV0aG9yPjxhdXRob3I+U2lzLCBCLjwvYXV0
aG9yPjxhdXRob3I+U2luZ2gsIEguIEsuPC9hdXRob3I+PGF1dGhvcj5TY2hpbnN0b2NrLCBDLjwv
YXV0aG9yPjxhdXRob3I+VGFtYnVyLCBBLjwvYXV0aG9yPjxhdXRob3I+WmVldmksIEEuPC9hdXRo
b3I+PGF1dGhvcj5NZW5nZWwsIE0uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh
dXRoLWFkZHJlc3M+UGFyaXMgVHJhbnNsYXRpb25hbCByZXNlYXJjaCBDZW50ZXIgZm9yIG9yZ2Fu
IHRyYW5zcGxhbnRhdGlvbiBJTlNFUk0gVTk3MCAmYW1wOyBOZWNrZXIgSG9zcGl0YWwgVW5pdmVy
c2l0eSBQYXJpcyBEZXNjYXJ0ZXMsIFBhcmlzLCBGcmFuY2UuJiN4RDtEZXBhcnRtZW50IG9mIFBh
dGhvbG9neSAmYW1wOyBMYWJvcmF0b3J5IE1lZGljaW5lLCBDZWRhcnMtU2luYWkgTWVkaWNhbCBD
ZW50ZXIsIExvcyBBbmdlbGVzLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIExhYm9yYXRvcnkgTWVk
aWNpbmUgYW5kIFBhdGhvbG9neSwgVW5pdmVyc2l0eSBvZiBBbGJlcnRhLCBFZG1vbnRvbiwgQ2Fu
YWRhLiYjeEQ7RGVwYXJ0bWVudCBvZiBMYWJvcmF0b3J5IE1lZGljaW5lIGFuZCBQYXRob2xvZ3ks
IEpvaG5zIEhvcGtpbnMgVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUsIEJhbHRpbW9yZSwg
TUQsIFVTQS4mI3hEO1BhcmlzIFRyYW5zbGF0aW9uYWwgcmVzZWFyY2ggQ2VudGVyIGZvciBvcmdh
biB0cmFuc3BsYW50YXRpb24gJmFtcDsgRGVwYXJ0bWVudCBvZiBOZXBocm9sb2d5IGFuZCBUcmFu
c3BsYW50YXRpb24sIEhvcGl0YWwgU2FpbnQgTG91aXMsIFVuaXZlcnNpdGUgUGFyaXMgVklJIGFu
ZCBJTlNFUk0gVSAxMTYwLCBQYXJpcywgRnJhbmNlLiYjeEQ7TmVwaHJvbG9neSBEZXBhcnRtZW50
LCBIb3NwaXRhbCBWYWxsIGQmYXBvcztIZWJyb24sIEF1dG9ub21vdXMgVW5pdmVyc2l0eSBvZiBC
YXJjZWxvbmEsIFNwYWluLiYjeEQ7RGVwdC4gUmVuYWwgTWVkaWNpbmUsIFdlc3RtZWFkIEhvc3Bp
dGFsLCBTeWRuZXksIEF1c3RyYWxpYS4mI3hEO0RlcGFydG1lbnQgb2YgUGF0aG9sb2d5LCBNYXNz
YWNodXNldHRzIEdlbmVyYWwgSG9zcGl0YWwsIEhhcnZhcmQgTWVkaWNhbCBTY2hvb2wsIEJvc3Rv
biwgTUEsIFVTQS4mI3hEO0RlcGFydG1lbnRzIG9mIFBhdGhvbG9neSAmYW1wOyBJbnRlcm5hbCBN
ZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBUZXhhcyBNZWRpY2FsIEJyYW5jaCwgR2FsdmVzdG9uLCBU
WCwgVVNBLiYjeEQ7TW9udGVmaW9yZSBNZWRpY2FsIENlbnRlciwgQWxiZXJ0IEVpbnN0ZWluIENv
bGxlZ2Ugb2YgTWVkaWNpbmUsIEJyb254LCBOWSwgVVNBLiYjeEQ7RGl2aXNpb24gb2YgTmVwaHJv
bG9neSwgRGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgSm9obnMgSG9wa2lucyBVbml2ZXJzaXR5IFNj
aG9vbCBvZiBNZWRpY2luZSwgQmFsdGltb3JlLCBNRCwgVVNBLiYjeEQ7SW5zdGl0dXRlIG9mIFBh
dGhvbG9neSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBvZiBDb2xvZ25lLCBDb2xvZ25lLCBHZXJtYW55
LiYjeEQ7RGVwYXJ0bWVudCBvZiBMYWJvcmF0b3J5IE1lZGljaW5lIGFuZCBQYXRob2xvZ3ksIE1h
eW8gQ2xpbmljLCBSb2NoZXN0ZXIsIE1OLCBVU0EuJiN4RDtVbml2ZXJzaXR5IG9mIE1hcnlsYW5k
IFNjaG9vbCBvZiBNZWRpY2luZSwgQmFsdGltb3JlLCBNRCwgVVNBLiYjeEQ7QmVybGluIEluc3Rp
dHV0ZSBvZiBIZWFsdGggYW5kIERlcGFydG1lbnQgb2YgTmVwaHJvbG9neSBhbmQgQ3JpdGljYWwg
Q2FyZSBNZWRpY2luZSwgQ2hhcml0ZSBVbml2ZXJzaXRhdHNtZWRpemluLCBCZXJsaW4sIEdlcm1h
bnkuJiN4RDtEZXBhcnRtZW50IG9mIE5lcGhyb2xvZ3ksIExlaWRlbiBVbml2ZXJzaXR5IE1lZGlj
YWwgQ2VudGVyLCBMZWlkZW4sIHRoZSBOZXRoZXJsYW5kcy4mI3hEO0RlcGFydG1lbnQgb2YgUGF0
aG9sb2d5LCBVbml2ZXJzaXR5IG9mIE1hbml0b2JhLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50IG9m
IFBhdGhvbG9neSAmYW1wOyBJbW11bm9sb2d5LCBXYXNoaW5ndG9uIFVuaXZlcnNpdHksIFN0LiBM
b3VpcywgTU8sIFVTQS4mI3hEO0RpdmlzaW9uIG9mIE5lcGhyb2xvZ3kgYW5kIEh5cGVydGVuc2lv
biwgRGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgTmV3IFlvcmsgUHJlc2J5dGVyaWFuIEhvc3BpdGFs
LVdlaWxsIENvcm5lbGwgTWVkaWNpbmUsIE5ldyBZb3JrLCBOWSwgVVNBLiYjeEQ7RGVwYXJ0bWVu
dCBvZiBQYXRob2xvZ3kgYW5kIExhYm9yYXRvcnkgTWVkaWNpbmUsIFVuaXZlcnNpdHkgb2YgTm9y
dGggQ2Fyb2xpbmEsIENoYXBlbCBIaWxsLCBOb3J0aCBDYXJvbGluYSwgVVNBLiYjeEQ7RGl2aXNp
b24gb2YgVHJhbnNwbGFudGF0aW9uIFBhdGhvbG9neSwgVGhlIFRob21hcyBFIFN0YXJ6bCBUcmFu
c3BsYW50YXRpb24gSW5zdGl0dXRlLCBVbml2ZXJzaXR5IG9mIFBpdHRzYnVyZ2guJiN4RDtEZXBh
cnRtZW50IG9mIFBhdGhvbG9neSBhbmQgTGFib3JhdG9yeSBNZWRpY2luZSwgVW5pdmVyc2l0eSBv
ZiBDYWxpZm9ybmlhLCBMb3MgQW5nZWxlcy4mI3hEO0RlcHQgQ2VsbHVsYXIgUGF0aG9sb2d5LCBI
YW1tZXJzbWl0aCBIb3NwaXRhbCwgTG9uZG9uLCBVSy4mI3hEO0RlcGFydG1lbnQgb2YgUGF0aG9s
b2d5LCBXZWlsbCBDb3JuZWxsIE1lZGljaW5lLCBOZXcgWW9yaywgVVNBLiYjeEQ7RGl2aXNpb24g
b2YgTmVwaHJvbG9neSwgTWF5byBDbGluaWMsIFJvY2hlc3RlciwgTU4sIFVTQS4mI3hEO0NvbXBy
ZWhlbnNpdmUgVHJhbnNwbGFudCBDZW50ZXIsIFRyYW5zcGxhbnQgSW1tdW5vbG9neSBMYWJvcmF0
b3J5LCBOb3J0aHdlc3Rlcm4gVW5pdmVyc2l0eSwgQ2hpY2FnbywgSUwsIFVTQS4mI3hEO1VuaXZl
cnNpdHkgb2YgUGl0dHNidXJnaCBNZWRpY2FsIENlbnRlciwgUGl0dHNidXJnaCwgUEEuPC9hdXRo
LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIEJhbmZmIDIwMTUgS2lkbmV5IG1lZXRpbmcgcmVw
b3J0OiBDdXJyZW50IGNoYWxsZW5nZXMgaW4gcmVqZWN0aW9uIGNsYXNzaWZpY2F0aW9uIGFuZCBw
cm9zcGVjdHMgZm9yIGFkb3B0aW5nIG1vbGVjdWxhciBwYXRob2xvZ3k8L3RpdGxlPjxzZWNvbmRh
cnktdGl0bGU+QW0gSiBUcmFuc3BsYW50PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlv
ZGljYWw+PGZ1bGwtdGl0bGU+QW0gSiBUcmFuc3BsYW50PC9mdWxsLXRpdGxlPjxhYmJyLTE+QW1l
cmljYW4gam91cm5hbCBvZiB0cmFuc3BsYW50YXRpb24gOiBvZmZpY2lhbCBqb3VybmFsIG9mIHRo
ZSBBbWVyaWNhbiBTb2NpZXR5IG9mIFRyYW5zcGxhbnRhdGlvbiBhbmQgdGhlIEFtZXJpY2FuIFNv
Y2lldHkgb2YgVHJhbnNwbGFudCBTdXJnZW9uczwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+
MjgtNDE8L3BhZ2VzPjx2b2x1bWU+MTc8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48ZGF0ZXM+
PHllYXI+MjAxNzwveWVhcj48L2RhdGVzPjxpc2JuPjE2MDAtNjE0MyAoRWxlY3Ryb25pYykmI3hE
OzE2MDAtNjEzNSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+Mjc4NjI4ODM8L2FjY2Vz
c2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5p
aC5nb3YvcHVibWVkLzI3ODYyODgzPC91cmw+PHVybD5odHRwOi8vb25saW5lbGlicmFyeS53aWxl
eS5jb20vc3RvcmUvMTAuMTExMS9hanQuMTQxMDcvYXNzZXQvYWp0MTQxMDcucGRmP3Y9MSZhbXA7
dD1pd2Y1bWQ5bCZhbXA7cz1mNWJiNjFlNDUxMDJlYzYyMjMwZmVmOGFlZDFkYjE2MTQxYTZiNTQ4
PC91cmw+PHVybD5odHRwOi8vb25saW5lbGlicmFyeS53aWxleS5jb20vc3RvcmUvMTAuMTExMS9h
anQuMTQxMDcvYXNzZXQvYWp0MTQxMDcucGRmP3Y9MSZhbXA7dD1pd2Y1bjQ2NCZhbXA7cz01OGE2
NjJkNWIwMzRlYTg2NWI5YWE4YTMyNmU2MjBmN2JmNmYwZDRkPC91cmw+PC9yZWxhdGVkLXVybHM+
PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTExL2FqdC4xNDEwNzwvZWxlY3Ry
b25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE.DATA (3)PyelonephritisInflammation of the transplant parenchyma caused by bacterial or fungal infection, usually ascending from the bladder. This falls within the remit of Banff Diagnostic Category 6. As an Infection, the presence of Pyelonephritis has important bearings on the diagnosis of Active AMR and Chronic Active AMR, as then Banff Lesion Score g must be equal or greater than 1 to fulfil the criteria for Microvascular inflammation, Moderate (Banff Lesion Score g + ptc ≥2).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1)Polyomavirus NephropathyReplicative infection of the kidney by polyoma virus as indicated by viral inclusions seen on histology, immunohistochemistry and/or electron microscopy. A Banff Working Group for Polyomavirus Nephropathy has developed and validated a respective scoring schema, which was presented at the meeting in 2017 and has been published recently. The percentage of tubules with replicative BK virus infection and Banff Lesion Score ci inform the classification from 1 to 3.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWNrZWxlaXQ8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFy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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWNrZWxlaXQ8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFy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=
ADDIN EN.CITE.DATA (9) Polyomavirus nephropathy is included in Banff Diagnostic Category 6 as BK-Virus Nephropathy.Scarred Cortical ParenchymaCharacterised by cortical tubular atrophy, usually but not always accompanied by interstitial fibrosis –see Tubular Atrophy. Banff Lesion Score i must not be scored in these areas, instead Banff Lesion Score i-IFTA is assessed in the areas.Subcapsular CortexThis term refers to areas immediately beneath the capsule, which may show areas of non-specific scarring or inflammation thought to be related to surgical ‘healing in’. ADDIN EN.CITE <EndNote><Cite><Author>Solez</Author><Year>1993</Year><RecNum>5850</RecNum><DisplayText>(<style face="italic">10</style>)</DisplayText><record><rec-number>5850</rec-number><foreign-keys><key app="EN" db-id="90tpszswbfs2f3evsw8vz9a52vrp9e2xa95e" timestamp="0">5850</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Solez, K.</author><author>Axelsen, R. A.</author><author>Benediktsson, H.</author><author>Burdick, J. F.</author><author>Cohen, A. H.</author><author>Colvin, R. B.</author><author>Croker, B. P.</author><author>Droz, D.</author><author>Dunnill, M. S.</author><author>Halloran, P. F.</author><author>et al.,</author></authors></contributors><auth-address>Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.</auth-address><titles><title>International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology</title><secondary-title>Kidney Int</secondary-title><alt-title>Kidney international</alt-title></titles><periodical><full-title>Kidney Int</full-title><abbr-1>Kidney international</abbr-1></periodical><alt-periodical><full-title>Kidney Int</full-title><abbr-1>Kidney international</abbr-1></alt-periodical><pages>411-22</pages><volume>44</volume><number>2</number><edition>1993/08/01</edition><keywords><keyword>Graft Rejection/*pathology</keyword><keyword>Humans</keyword><keyword>*International Cooperation</keyword><keyword>Kidney/*pathology</keyword><keyword>*Kidney Transplantation</keyword><keyword>Pathology/standards</keyword><keyword>Reference Standards</keyword><keyword>Terminology as Topic</keyword></keywords><dates><year>1993</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0085-2538 (Print)
0085-2538</isbn><accession-num>8377384</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>(10) The extent of the cortex that qualifies as “subcapsular” has not been more clearly defined in the Banff Classification. Banff Lesion Scores ptcPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tb2xlejwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tb2xlejwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJl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ADDIN EN.CITE.DATA (11) and iPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWN1c2VuPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWN1c2VuPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48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ADDIN EN.CITE.DATA (2) must not be scored in these areas.T-cell-mediated rejection (TCMR)The spectrum of TCMR is defined as Banff Diagnostic Category 4 which contains Acute TCMR Grade IA, IB, IIA, IIB, III as well as Chronic Active TCMR Grade IA, IB and II. Suspicious (Borderline) For Acute TCMR is the only diagnosis in Banff Diagnostic Category 3. Banff Diagnostic Categories 3 and 4 are mutually exclusive but can be rendered together with other diagnoses from Categories 2, 5 and 6.Thrombotic Microangiopathy, Thrombotic Microangiopathy In The Absence Of Any Other CauseThrombotic microangiopathy (TMA) can be caused by recurrent disease (usually atypical haemolytic-uremic syndrome), AMR, Calcineurin Inhibitor Toxicity (included in Banff Diagnostic Category 6) and other causes.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ob3JpczwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ob3JpczwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA (12) If there is evidence of chronic TMA, Banff Lesion Score cg must not be used as a criterion for histological evidence of chronic tissue injury in the diagnosis of either Chronic Active AMR or Chronic AMR.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1)Transplant ArteriopathyTransplant Arteriopathy is defined as arterial fibrointimal thickening, also referred to as vascular fibrous intimal thickening, and is graded based on the extent of luminal occlusion in the most severely affected artery. Transplant arteriopathy is scored with the Banff Lesion Score cv. Features that suggest Chronic Active TCMR Grade II or Chronic Active AMR versus other causes such as conventional arteriosclerosis or hypertension are disruption of the elastica, inflammatory cells in the fibrotic intima, proliferation of myofibroblasts and/or foam cells in the expanded intima, formation of a neointima.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3VweTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl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 EN.CITE.DATA (3) However, it should be noted that bland but progressive intimal fibrosis may be associated with the presence of DSA.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IaWxsPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IaWxsPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (13)Transplant GlomerulopathyTransplant glomerulopathy is defined as a Banff Lesion Score cg greater than 0, after the exclusion of chronic thrombotic microangiopathy, recurrent or de novo Glomerulonephritis. It is not synonymous to AMR, but is frequently associated with it.Tubular AtrophyModerately atrophic tubules are defined as tubules having a diameter <50% of that of unaffected or minimally affected tubules on the biopsy, with wrinkling and/or thickening of the tubular basement membrane.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWN1c2VuPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWN1c2VuPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48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ADDIN EN.CITE.DATA (2) Severely atrophic tubules are defined as tubules of diameter <25% of that of unaffected or minimally affected tubules on the biopsy, often with an undifferentiated-appearing, cuboidal or flattened epithelium (or in some cases even loss of epithelium with denudation of the tubular basement membrane), and pronounced wrinkling and/or thickening of the tubular basement membrane. This definition of severely atrophic tubules also includes very small, endocrine-like tubules with very narrow lumens, although the basement membranes of the latter may not be thickened.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1) According to Banff 2017, severely atrophic tubules should be disregarded for Banff Lesion Score t.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWFzPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (1)References ADDIN EN.REFLIST 1.Haas M, Loupy A, Lefaucheur C et al. The Banff 2017 Kidney Meeting Report: Revised Diagnostic Criteria for Chronic Active T Cell-Mediated Rejection, Antibody-Mediated Rejection, and Prospects for Integrative Endpoints for Next-Generation Clinical Trials. Am J Transplant 20172.Racusen LC, Solez K, Colvin RB et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999;55(2):713-7233.Loupy A, Haas M, Solez K et al. The Banff 2015 Kidney meeting report: Current challenges in rejection classification and prospects for adopting molecular pathology. Am J Transplant 2017;17(1):28-414.Haas M, Sis B, Racusen LC et al. Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am J Transplant 2014;14(2):272-2835.Regele H, Bohmig GA, Habicht A et al. Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection. J Am Soc Nephrol 2002;13(9):2371-23806.Bonsib SM. Renal Anatomy and Histology. In: Jennette CJ, Silva FG, Olson JL, et al., eds. Heptinstall's Pathology of the Kidney. Lippincot Williams & Wilkins: Philadelphia, PA, USA; 2015, 1-66.7.Tait BD, Susal C, Gebel HM et al. Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation. Transplantation 2013;95(1):19-478.Solez K, Colvin RB, Racusen LC et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 2008;8(4):753-7609.Nickeleit V, Singh HK, Randhawa P et al. The Banff Working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical Correlations. J Am Soc Nephrol 201710.Solez K, Axelsen RA, Benediktsson H et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int 1993;44(2):411-42211.Solez K, Colvin RB, Racusen LC et al. Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007;7(3):518-52612.Noris M, Remuzzi G. Thrombotic microangiopathy after kidney transplantation. Am J Transplant 2010;10(7):1517-152313.Hill GS, Nochy D, Bruneval P et al. Donor-specific antibodies accelerate arteriosclerosis after kidney transplantation. J Am Soc Nephrol 2011;22(5):975-983 ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related searches
- andy williams a time for us
- aarp supplemental health insurance log in
- texes esl supplemental 154 practice test
- oregon homecare workers supplemental trust
- aarp united healthcare supplemental insurance
- aarp supplemental insurance eligibility
- uchicago supplemental essay examples
- university of chicago supplemental essay
- homecare worker supplemental trust
- sherwin williams color of the year
- sherwin williams best neutrals 2019
- top sherwin williams neutral colors