ZYN : THE FUTURE OF NICOTINE; TOBACCO FREE NICOTINE …
[Pages:19]ZYN?: THE FUTURE OF NICOTINE; TOBACCO FREE NICOTINE PODS
Dr. Johan Lindholm
Director Analytical & Product Science
Dr. Mikael Staaf
Manager Product Science
Dr. Lars E. Rutqvist
Senior Vice President Scientific Affairs
Thord Hassler
Vice President R&D
1
THE EVOLUTION OF NICOTINE
Cigarettes
Smokeless
Pouches
Snus
E-cig/Vape
Next Gen
Nicotine of choice for decades
Health warnings emerged in 1960's
Smoking restrictions introduced in 1970's
Smokers begin looking for more discrete alternatives to smoking that still satisfy.
No smoke = more discrete than smoking
Provided consumers with an option as smoking restrictions expanded
Many smokers didn't like the mouth feel or spitting associated with STP
STP oral health warnings issued in 1980's
More convenient and easier to use appealed to more smokers
More discrete than loose smokeless tobacco
More discrete than moist snuff/pouches
No spitting required
General snus was first product approved for Pre-Market Tobacco Product Application (PMTA) by FDA
First non-tobacco nicotine products emerge
Inhaled nicotine vapor, not tobacco
Vapor clouds still identify user as a smoker, less discrete than snus
Vape restrictions first appear in 2010's
Next gen products for consumers must be:
- Smokeless - Spitless - Discrete - Convenient - Tobacco Free - Recreational
Most importantly, next gen products must satisfy and meet a wide variety of consumer preferences
* A. McNeill, et al., Public Health England (2015), publications gateway: 2015260
D.J. Nutt, et al., Eur Addict Res (2014); 20: 218?225
Ii-Lun Chen, CTP presentation, Society for Research on Nicotine and Tobacco, Chicago, USA (2016)
2
VOLUME DEVELOPMENT FOR CIGARETTES AND SNUS IN SWEDEN AND NORWAY
1916 1923 1930 1937 1944 1951 1958 1965 1972 1979 1986 1993 2000 2007 2014
Cigarettes
(million packs)
700 630 560 490 420 350 280 210 140
70 0
Sweden
Cigarettes 1973: First Snus
portion snus launched
Snus
(million cans)
250 225 200 175 150 125 100 75 50 25 0
35 30 25 20 15 10
5 0
1985
Norway
Share of population (%)
Cigarette smokers
Snus users
1990
1995
2000
2005
2010
SNUS IS OUTPERFORMING CIGARETTES IN SWEDEN AND NORWAY
Source Sweden: SMD Logistics and Swedish Match estimates
Source Norway: The Norwegian Directorate of Health
3
RECORD LOW PREVALENCE OF SMOKING IN SWEDEN
Proportion of daily cigarette smokers (percentage of population aged 15 and over)
40% 35% 30% 25% 20% 15% 10%
5% 0%
Source: Special Eurobarometer 458, European Commission 4
...IS MIRRORED IN THE PUBLIC HEALTH STATISTICS...LOWEST INCIDENCE OF TOBACCO RELATED CANCER
90
Lung cancer among men in Europe
80
Incidence ASR (W) , new cases per 100,000 males Source: WHO/IARC, 2008
70
60
50
40
30
20
10
0
35
Oral and pancreatic cancer combined among men in Europe
30
Incidence ASR (W) , new cases per 100,000 males Source: WHO/IARC, 2008
25
20
15
10
5
0
SWE PT FI MA NO AU IR UK CH DE DK IT LU NL FR
SLK GR ESP BU RO SLO LA CZ LI BE EST PL HU SWE GR
IR UK NO NL CH MA
FI AU
IT DE PT BE FR LA PL DK BU SLO EST ESP LU CZ LI RO SLK HU
SNUS HAS CONTRIBUTED SIGNIFICANTLY TO IMPROVED PUBLIC HEALTH
Mortality Attributable to Tobacco, Men per 100 000, *WHO 2012
800
700
Among the smokeless tobacco products
on the market, products with low levels
600
of nitrosamines, such as Swedish snus,
are considerably less hazardous than
cigarettes*
500
400
300
200
100
0
* World Health Organization: WHO Global Report: Mortality Attributable to Tobacco. 2012
GOTHIATEK? - SWEDISH MATCH QUALITY STANDARD FOR SNUS
The "Swedish Experience" ? A "real world illustration" of tobacco harm reduction
? One component of the public health success of snus is that it is manufactured according to the GOTHIATEK? standard
GOTHIATEK? - the world?s strictest product standard for any tobacco product
? The standard was introduced in the year 2000
- Based on decades of research and development with consumer protection, product safety and openness as key targets
? Applicable to all Swedish Match Snus products ? The basis for Swedish Match ambition to
- Produce the best snus products
- Use the best manufacturing practices - Continue to improve the products - Maintain the lowest possible levels of undesirable constituents in snus
? Dynamic - continuous development
- Techniques and processes are improved
- New scientific data is made available
GOTHIATEK? STANDARD ? MAXIMUM LEVELS FOR SELECTED CONSTITUENTS
Total TSNAs, NNN+NNK (g/g) B(a)P (ng/g)
25
GOTHIATEK? requires that finished products
shall not exceed the maximum allowable
levels of certain harmful and potential
20
harmful constituents. These constituents
originate from the environment or from the
15
tobacco plant
The standard has over the years been
10
amended at several occasions: the range of
compounds has been expanded and the
maximum levels lowered
5
25
20
Total TSNAs
NNN
NNK
15
B(a)P
10
5
0 1984
1988
1992
1996
2000
2004
2008
2012
0 2016
year
All values based om dry weight
*WHO Tob. Reg. Report 955, Scientific Basis of Tobacco Product Regulation 2010
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