Eprints.keele.ac.uk
Rheumatic fever following group A streptococcus infection is the predominant cause for rheumatic valvular heart disease. Progressive damage to the heart and its valves is associated with clinical complications such as asymptomatic irreversible ventricular dysfunction, pulmonary hypertension, atrial fibrillation and flutter, and stroke, which are major causes of long-term morbidity29. ................
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