The use of the lower limit of normal derived post ...
ONLINE SUPPLEMENT
proportional classifications of COPD phenotypes
1Suzanne E Marsh, 1Justin Travers, 2Mark Weatherall, 1Mathew V Williams,
1Sarah Aldington, 1Philippa M Shirtcliffe, 3Anna L Hansell, 2,4Michael R Nowitz,
1Amanda A McNaughton, 5Joan B Soriano, 1,6Richard W Beasley
1Medical Research Institute of New Zealand, Wellington, New Zealand
2Wellington School of Medicine & Health Sciences, Wellington, New Zealand
3Department of Epidemiology and Public Health, Imperial College London
4Pacific Radiology Limited, Wellington, New Zealand
5Fundació Caubet–CIMERA Illes Balears, Bunyola, Spain
6University of Southampton, Southampton, United Kingdom
Correspondence:
Professor Richard Beasley
Medical Research Institute of New Zealand
PO Box 10055, Wellington 6143, New Zealand
Telephone: +64-4-472 9199
Facsimile: +64-4-472 9224
Email: Richard.Beasley@mrinz.ac.nz
RESULTS
The use of the lower limit of normal derived post-bronchodilator FEV1/FVC ratios, rather than the fixed ratio of 0.7 resulted in 37 fewer subjects classified as COPD (Table E1). The main difference resulting from the use of the lower limit of normal derived post-bronchodilator FEV1/FVC ratios to define COPD, was that a smaller proportion of subjects with COPD did not meet the criteria for any of the asthma, chronic bronchitis, or emphysema phenotypes [9/59 (15%) versus 25/96 (26%) using the lower limit of normal vs fixed post-bronchodilator FEV1/FVC ratio ................
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