The use of the lower limit of normal derived post ...



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proportional classifications of COPD phenotypes

1Suzanne E Marsh, 1Justin Travers, 2Mark Weatherall, 1Mathew V Williams,

1Sarah Aldington, 1Philippa M Shirtcliffe, 3Anna L Hansell, 2,4Michael R Nowitz,

1Amanda A McNaughton, 5Joan B Soriano, 1,6Richard W Beasley

1Medical Research Institute of New Zealand, Wellington, New Zealand

2Wellington School of Medicine & Health Sciences, Wellington, New Zealand

3Department of Epidemiology and Public Health, Imperial College London

4Pacific Radiology Limited, Wellington, New Zealand

5Fundació Caubet–CIMERA Illes Balears, Bunyola, Spain

6University of Southampton, Southampton, United Kingdom

Correspondence:

Professor Richard Beasley

Medical Research Institute of New Zealand

PO Box 10055, Wellington 6143, New Zealand

Telephone: +64-4-472 9199

Facsimile: +64-4-472 9224

Email: Richard.Beasley@mrinz.ac.nz

RESULTS

The use of the lower limit of normal derived post-bronchodilator FEV1/FVC ratios, rather than the fixed ratio of 0.7 resulted in 37 fewer subjects classified as COPD (Table E1). The main difference resulting from the use of the lower limit of normal derived post-bronchodilator FEV1/FVC ratios to define COPD, was that a smaller proportion of subjects with COPD did not meet the criteria for any of the asthma, chronic bronchitis, or emphysema phenotypes [9/59 (15%) versus 25/96 (26%) using the lower limit of normal vs fixed post-bronchodilator FEV1/FVC ratio ................
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