University of Dundee



The year 2019 in cardiology: aorta and peripheral circulationChristian Heiss,1 Alex Pitcher,2 Jill JF Belch,3 Marco De Carlo,4 Holger Reinecke,5 Iris Baumgartner,6 Lucia Mazzolai,7 Victor Aboyans,8 on behalf of the ESC Working Group on Aorta and Peripheral Vascular Diseases. 1Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH and Surrey and Sussex Healthcare NHS Trust, Redhill RH1 5RH, UK2Division of Cardiovascular Medicine, Radcliffe Dept. of Medicine, University of Oxford, Oxford, UK; 3The Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK4Cardiac Catheterization Laboratory, Cardiothoracic and Vascular Department, Azienda Ospealiero-Universitaria Pisana, via Paradisa2, 56100 Pisa, Italy5Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure.University Hospital Muenster, Albert Schweitzer Campus 1, A1, 48149 Muenster, Germany6Klinik und Poliklinik fu?r Angiologie, Departement Herz und Gefa?sse, Universita?t Bern, Bern, Switzerland7Division of Angiology, Department of Heart and Vessel, Lausanne University Hospital, Ch du Mont-Paisible 18, Lausanne, 1011, Switzerland8Department of Cardiology, Dupuytren University Hospital, 2, Martin Luther King Ave., and Inserm 1094, Limoges School of Medicine, Ave Dr. Marcland, 87025 Limoges, FranceAddress for correspondence:Prof. Dr. Christian HeissDepartment of Clinical and Experimental MedicineUniversity of SurreyStag HillGuildford GU2 7XH, United KingdomPhone: +44 (0) 1737 231749Email: c.heiss@surrey.ac.ukPreambleSimilar to previous years,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZSBDYXJsbzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+

PFJlY051bT40MDY0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+MS0zPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA2NDwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDU4MDU2Ij40MDY0PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhvcj48

YXV0aG9yPk1henpvbGFpLCBMLjwvYXV0aG9yPjxhdXRob3I+Qm9zc29uZSwgRS48L2F1dGhvcj48

YXV0aG9yPkJyb2RtYW5uLCBNLjwvYXV0aG9yPjxhdXRob3I+TWljYXJpLCBBLjwvYXV0aG9yPjxh

dXRob3I+TXVpZXNhbiwgTS4gTC48L2F1dGhvcj48YXV0aG9yPlJpY2NvLCBKLiBCLjwvYXV0aG9y

PjxhdXRob3I+U3RhYmlsZSwgRS48L2F1dGhvcj48YXV0aG9yPkFnbmVsbGksIEcuPC9hdXRob3I+

PGF1dGhvcj5BYm95YW5zLCBWLjwvYXV0aG9yPjxhdXRob3I+RS4gUy4gQy4gV29ya2luZyBHcm91

cCBvbiBBb3J0YTwvYXV0aG9yPjxhdXRob3I+UGVyaXBoZXJhbCBWYXNjdWxhciwgRGlzZWFzZXM8

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DYXJkaWFjIENh

dGhldGVyaXphdGlvbiBMYWJvcmF0b3J5LCBDYXJkaW90aG9yYWNpYyBhbmQgVmFzY3VsYXIgRGVw

YXJ0bWVudCwgQXppZW5kYSBPc3BlZGFsaWVyby1Vbml2ZXJzaXRhcmlhIFBpc2FuYSwgdmlhIFBh

cmFkaXNhIDIsIDU2MTAwIFBpc2EsIEl0YWx5LiYjeEQ7RGVwYXJ0bWVudCBvZiBBbmdpb2xvZ3ks

IExhdXNhbm5lIFVuaXZlcnNpdHkgSG9zcGl0YWwsIFJ1ZSBkdSBCdWdub24gNDYsIDEwMTEgTGF1

c2FubmUsIFN3aXR6ZXJsYW5kLiYjeEQ7Q2FyZGlvbG9neSBEaXZpc2lvbiwgJnF1b3Q7Q2F2YSBk

ZSZhcG9zOyBUaXJyZW5pIGFuZCBBbWFsZmkgQ29hc3QmcXVvdDssIEhlYXJ0IERlcGFydG1lbnQs

IFVuaXZlcnNpdHkgSG9zcGl0YWwsIFZpYSBFbnJpY28gZGUgTWFyaW5pcywgODQwMTMgQ2F2YSBk

ZSZhcG9zOyBUaXJyZW5pIChTQSksIEl0YWx5LiYjeEQ7RGl2aXNpb24gb2YgQW5naW9sb2d5LCBN

ZWRpY2FsIFVuaXZlcnNpdHkgR3JheiwgQXVlbmJydWdnZXJwbGF0eiAxNSwgODAzNiBHcmF6LCBB

dXN0cmlhLiYjeEQ7R1ZNIENhcmUgYW5kIFJlc2VhcmNoLCBNYXJpYSBDZWNpbGlhIEhvc3BpdGFs

LCB2aWEgQ29ycmllcmEgMSwgNDgwMzMgQ290aWdub2xhIChSQSksIEl0YWx5LiYjeEQ7Q2xpbmlj

YWwgYW5kIEV4cGVyaW1lbnRhbCBTY2llbmNlcyBEZXBhcnRtZW50LCBVbml2ZXJzaXR5IG9mIEJy

ZXNjaWEsIFBpYXp6YWxlIFNwZWRhbGkgQ2l2aWxpIDEsIDI1MTIzIEJyZXNjaWEsIEl0YWx5LiYj

eEQ7RGVwYXJ0bWVudCBvZiBWYXNjdWxhciBTdXJnZXJ5LCBVbml2ZXJzaXR5IEhvc3BpdGFsIG9m

IFBvaXRpZXJzLCAyIFJ1ZSBkZSBsYSBNaWxldHJpZSwgODYwMjEgUG9pdGllcnMsIEZyYW5jZS4m

I3hEO0RpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIERlcGFydG1lbnQgb2YgQWR2YW5jZWQgQmlvbWVk

aWNhbCBTY2llbmNlcywgVW5pdmVyc2l0eSBvZiBOYXBvbGkgJnF1b3Q7RmVkZXJpY28gSUkmcXVv

dDssIENvcnNvIFVtYmVydG8gSSA0MCwgODAxMzggTmFwb2xpLCBJdGFseS4mI3hEO0ludGVybmFs

IGFuZCBDYXJkaW92YXNjdWxhciBNZWRpY2luZSAtIFN0cm9rZSBVbml0LCBVbml2ZXJzaXR5IG9m

IFBlcnVnaWEsIFZpYWxlIFplZmZlcmlubyBGYWluYSA0LCAwNjEyMyBQZXJ1Z2lhLCBJdGFseS4m

I3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgRHVwdXl0cmVuIFVuaXZlcnNpdHkgSG9zcGl0

YWwsIExpbW9nZXMsIGFuZCBJbnNlcm0gMTA5NCwgVHJvcGljYWwgTmV1cm9lcGlkZW1pb2xvZ3ks

IFVuaXZlcnNpdHkgb2YgTGltb2dlcywgMzMgUnVlIEZyYW5jb2lzIE1pdHRlcnJhbmQsIDg3MDMy

IExpbW9nZXMsIEZyYW5jZS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgeWVhciBp

biBjYXJkaW9sb2d5IDIwMTY6IHBlcmlwaGVyYWwgY2lyY3VsYXRpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+MTAy

OC0xMDMzPC9wYWdlcz48dm9sdW1lPjM4PC92b2x1bWU+PG51bWJlcj4xNDwvbnVtYmVyPjxrZXl3

b3Jkcz48a2V5d29yZD5Bb3J0aWMgRGlzZWFzZXMvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+

Q2FyZGlvdmFzY3VsYXIgQWdlbnRzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5D

YXJvdGlkIEFydGVyeSBEaXNlYXNlcy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8

L2tleXdvcmQ+PGtleXdvcmQ+TGVnL2Jsb29kIHN1cHBseTwva2V5d29yZD48a2V5d29yZD5QZXJp

cGhlcmFsIFZhc2N1bGFyIERpc2Vhc2VzLyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlJhbmRv

bWl6ZWQgQ29udHJvbGxlZCBUcmlhbHMgYXMgVG9waWM8L2tleXdvcmQ+PGtleXdvcmQ+U3RlbnRz

PC9rZXl3b3JkPjxrZXl3b3JkPlZlbm91cyBUaHJvbWJvZW1ib2xpc20vKnRoZXJhcHk8L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkFw

ciA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmlj

KSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yODA0Mzk3OTwv

YWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5u

bG0ubmloLmdvdi9wdWJtZWQvMjgwNDM5Nzk8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNp

bHZlcmNoYWlyLmNvbS9laHc2NDMucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0Vy

Y3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJ

Q2FRSUJBRENDQW1JR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTVZ0WldSQ0xx

UUdhVHVaa3pBZ0VRZ0lJQ005RncxVHFHd2F4REtQalJId01ZR215eXZyTVI3dG1zTmVRWkVaNHRY

NVhuUzBGWF9vaVk2UktJZHVrRHVWSHdDZmtUSGxPQVExV08yQ0lvNk9FX1BTaGE5cHFoNDJlalZx

bkRraXVaNVdDSE9JWENoYk9DS2xCeHhwQVNmSlNudm9DWGM1bEg4dkducGxRQXVTRUg3bTR0STdS

VmdsSXdUYUFXYzV2a2doUHNwNlVPdTU1WEhvR2l1dUt2ZFF2cHRXNTZjWGYyMWJfcEV5ejFiaTRE

LU1fX3dHdFd1djBGemxUazBxR0hFX2lwbFo2X19zcEtTeEFNLW5EUnFtS3FpNXpfQmh6ejZpUmpz

QllYbVVOX2VXbDloUy0zb2Y1TFZqN0pidW80VUZ2NWlfNUVtYm1QVnJPa0NjNzRpN0szcU8wZkVO

NGw3UEgzSmlBWlRIT2JuWV9CVUNVRlVXbWtkZkl3UXpKanZXdWtLaUtmMGFDbWppZGx4T3ZYWXdC

VElWUnc3QWk1WnpNMV85bmp0TnF3R3BicC12Rmd6UlJ0YXBKVzJrYk5oN0dQakdKamhwUXpuZlFo

dG50RE11OGxnVEtZckhTMWE3SFd0cVYyRGE1WmgzRlVmNmlvampCYS1RR0lnQzBDdmVFN1hCVVFf

bHZKQk0wUFFKRmVVZHM1eUM2bnlHQXN6aWdtOUQwOXp4YTlRREdoYVkyLVZvTkI1UlBPR09SSFVa

ZEV0U0hUTVF6Y0lTamF5c2VoUHM5VnN1X1lXTzktM001NmlfLXNvSDVmLVlLQm1HWVFKQmVxTHUw

N1ZOV0p4S2tRSFlhN0tZUHF2ekpMa2FicWd3UDBaaC10NjhmSnJzM2Z6c3cwNmhZVWdNOWZINF9y

RVhlS1p5NUw0eHNIaVo1VDlnZGdKMmRzUEVwcWxsUzBoOGcwdWdmS0dOVmo1Z1ZhSWM0YkhmdmJS

d3U4UWpHeUtod1M2YXVjczgzYTVaTjdWOVJZPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHc2NDM8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkFib3lhbnM8L0F1

dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNOdW0+NDA2MjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+NDA2MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjJlYXAwMmZmanhwemFzZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDU4

MDU2Ij40MDYyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BYm95YW5z

LCBWLjwvYXV0aG9yPjxhdXRob3I+VnJzYWxvdmljLCBNLjwvYXV0aG9yPjxhdXRob3I+TWFkYXJp

YywgSi48L2F1dGhvcj48YXV0aG9yPk1henpvbGFpLCBMLjwvYXV0aG9yPjxhdXRob3I+RGUgQ2Fy

bG8sIE0uPC9hdXRob3I+PGF1dGhvcj5FLiBTLiBDLiBXb3JraW5nIEdyb3VwIG9uIEFvcnRhPC9h

dXRob3I+PGF1dGhvcj5QZXJpcGhlcmFsIFZhc2N1bGFyLCBEaXNlYXNlczwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9n

eSwgRHVwdXl0cmVuIFVuaXZlcnNpdHkgSG9zcGl0YWwsIDIsIE1hcnRpbiBMdXRoZXIgS2luZyBB

dmUsIExpbW9nZXMsIEZyYW5jZS4mI3hEO1Jlc2VhcmNoIFVuaXQgSU5TRVJNIDEwOTQsIExpbW9n

ZXMgU2Nob29sIG9mIE1lZGljaW5lLCAyLCBhdmUgTWFyY2xhbmQsIExpbW9nZXMsIEZyYW5jZS4m

I3hEO1VuaXZlcnNpdHkgb2YgWmFncmViIFNjaG9vbCBvZiBNZWRpY2luZSwgU2FsYXRhIDMsIFph

Z3JlYiwgQ3JvYXRpYS4mI3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgU2VzdHJlIE1pbG9z

cmRuaWNlIFVuaXZlcnNpdHkgSG9zcGl0YWwgQ2VudHJlLCBWaW5vZ3JhZHNrYSAyOSwgWmFncmVi

LCBDcm9hdGlhLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5IGFuZCBBbmdpb2xvZ3ksIE5h

dGlvbmFsIEluc3RpdHV0ZSBvZiBDYXJkaW92YXNjdWxhciBEaXNlYXNlcywgUG9kIEtyYXNub3Ug

aG9ya291IDEsIEJyYXRpc2xhdmEsIFNsb3Zha2lhLiYjeEQ7RGl2aXNpb24gb2YgQW5naW9sb2d5

LCBIZWFydCBhbmQgVmVzc2VsIERlcGFydG1lbnQsIExhdXNhbm5lIFVuaXZlcnNpdHkgSG9zcGl0

YWwsIFJ1ZSBkdSBCdWdub24gNDYsIExhdXNhbm5lLCBTd2l0emVybGFuZC4mI3hEO0NhcmRpYWMg

Q2F0aGV0ZXJpemF0aW9uIExhYm9yYXRvcnksIENhcmRpb3Rob3JhY2ljIGFuZCBWYXNjdWxhciBE

ZXBhcnRtZW50LCBBemllbmRhIE9zcGVkYWxpZXJvLVVuaXZlcnNpdGFyaWEgUGlzYW5hLCB2aWEg

UGFyYWRpc2EgMiwgUGlzYSwgSXRhbHkuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhl

IHllYXIgMjAxOCBpbiBjYXJkaW9sb2d5OiBhb3J0YSBhbmQgcGVyaXBoZXJhbCBjaXJjdWxhdGlv

bjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwYWdlcz44NzItODc5PC9wYWdlcz48dm9sdW1lPjQwPC92b2x1bWU+PG51bWJlcj4x

MTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyIDE0

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYj

eEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDYwMjAwNTwvYWNj

ZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0u

bmloLmdvdi9wdWJtZWQvMzA2MDIwMDU8L3VybD48dXJsPmh0dHBzOi8vYWNhZGVtaWMub3VwLmNv

bS9ldXJoZWFydGovYXJ0aWNsZS1hYnN0cmFjdC80MC8xMS84NzIvNTI2NzQ3Nj9yZWRpcmVjdGVk

RnJvbT1mdWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh5ODk5PC9lbGVjdHJvbmljLXJlc291cmNlLW51

bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5BYm95YW5zPC9BdXRob3I+PFllYXI+MjAx

ODwvWWVhcj48UmVjTnVtPjQwNjM8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQwNjM8L3Jl

Yy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHph

c2VzMnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTA1ODA1NiI+NDA2Mzwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QWJveWFucywgVi48L2F1dGhvcj48

YXV0aG9yPkJyYWVra2FuLCBTLjwvYXV0aG9yPjxhdXRob3I+TWF6em9sYWksIEwuPC9hdXRob3I+

PGF1dGhvcj5TaWxsZXNlbiwgSC48L2F1dGhvcj48YXV0aG9yPlZlbmVybW8sIE0uPC9hdXRob3I+

PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIFdvcmtpbmcgR3Jv

dXAgb24gQW9ydGE8L2F1dGhvcj48YXV0aG9yPlBlcmlwaGVyYWwgVmFzY3VsYXIsIERpc2Vhc2Vz

PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVu

dCBvZiBDYXJkaW9sb2d5LCBEdXB1eXRyZW4gVW5pdmVyc2l0eSBIb3NwaXRhbCwgMiwgTWFydGlu

IEx1dGhlciBLaW5nIEF2ZS4sIExpbW9nZXMsIEZyYW5jZS4mI3hEO0luc2VybSAxMDk0LCBMaW1v

Z2VzIFNjaG9vbCBvZiBNZWRpY2luZSwgQXZlIERyLiBNYXJjbGFuZCwgODcwMjUgTGltb2dlcywg

RnJhbmNlLiYjeEQ7Sy5HLiBKZWJzZW4gVGhyb21ib3NpcyBSZXNlYXJjaCBhbmQgRXhwZXJ0aXNl

IENlbnRlciAoVFJFQyksIERlcGFydG1lbnQgb2YgQ2xpbmljYWwgTWVkaWNpbmUsIFVpVCAtIFRo

ZSBBcmN0aWMgVW5pdmVyc2l0eSBvZiBOb3J3YXksIEhhbnNpbmUgSGFuc2VucyB2ZWcgMTgsIDkw

MzcsIFRyb21zbywgTm9yd2F5LiYjeEQ7RGl2aXNpb24gb2YgQW5naW9sb2d5LCBEZXBhcnRtZW50

IG9mIEhlYXJ0IGFuZCBWZXNzZWwsIExhdXNhbm5lIFVuaXZlcnNpdHkgSG9zcGl0YWwsIENoIGR1

IE1vbnQtUGFpc2libGUgMTgsIExhdXNhbm5lLCAxMDExLCBTd2l0emVybGFuZC4mI3hEO0RlcGFy

dG1lbnQgb2YgVmFzY3VsYXIgU3VyZ2VyeSwgUmlnc2hvc3BpdGFsZXQsIFVuaXZlcnNpdHkgb2Yg

Q29wZW5oYWdlbiwgQmxlZ2RhbXN2ZWogOSwgQ29wZW5oYWdlbiwgMjEwMCwgRGVubWFyay4mI3hE

O0RlcGFydG1lbnQgb2YgVmFzY3VsYXIgU3VyZ2VyeSwgSGVsc2lua2kgVW5pdmVyc2l0eSBIb3Nw

aXRhbCwgSGFhcnRtYW5pbmthdHUgNCwgRkktMDAyOTAgSGVsc2lua2ksIEZpbmxhbmQuJiN4RDtD

YXJkaWFjIENhdGhldGVyaXphdGlvbiBMYWJvcmF0b3J5LCBDYXJkaW90aG9yYWNpYyBhbmQgVmFz

Y3VsYXIgRGVwYXJ0bWVudCwgQXppZW5kYSBPc3BlYWxpZXJvLVVuaXZlcnNpdGFyaWEgUGlzYW5h

LCB2aWEgUGFyYWRpc2EsIFBpc2EsIEl0YWx5LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PlRoZSB5ZWFyIDIwMTcgaW4gY2FyZGlvbG9neTogYW9ydGEgYW5kIHBlcmlwaGVyYWwgY2lyY3Vs

YXRpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+NzMwLTczODwvcGFnZXM+PHZvbHVtZT4zOTwvdm9sdW1lPjxudW1i

ZXI+OTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFy

IDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMp

JiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI5MzAwODY4PC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3B1Ym1lZC8yOTMwMDg2ODwvdXJsPjx1cmw+aHR0cHM6Ly93YXRlcm1hcmsuc2ls

dmVyY2hhaXIuY29tL2VoeDgwMC5wZGY/dG9rZW49QVFFQ0FIaTIwOEJFNDlPb2FuOWtraFdfRXJj

eTdEbTNaTF85Q2YzcWZLQWM0ODV5c2dBQUFud3dnZ0o0QmdrcWhraUc5dzBCQndhZ2dnSnBNSUlD

WlFJQkFEQ0NBbDRHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFNRUFTNHdFUVFNWFNCSHFNUXVz

ejFFOVhTX0FnRVFnSUlDTDBjWFBBVFZNbVZKUUJfQmFvYUhBVnhpd2luUTNYZ1piQW53dkNEMTVz

dFc5UXhKVlZablZwQWQxNXdLVUU4eTdqeEV5V0RKMUJVLWhqQk5HQ2RiNmdDN2FqSFRUWGRmajI1

clZLU2s3akhfWVdsU2MyT2l6R1k3WGFxOGlMd0tHVWNUMWN6MUg4aU9qMHN4bU9kSTF6Wm5nUlA0

S1JPNC1JQTBDc0ZXR0U2VzhqdWNHcm1DazhMOXZ1UXNraUF5ZTN6V3NoUHlab3duWXZySWRVY29C

NlhMRGwyaWFDaFhJV0tBMzlNTVhsRnk3Q0NSc0x5TnVNYVBkZHgzZEp2LTlRSmhaZmdrZjVwLWNv

YV9nUTZ1X1c4a1dfS3ljbFB6ZGFFbHlMelE4aE1fMDU0NHhERE5wYktGOFJsNWhVWGpFenFPMEct

Y1V0VkowcFg0eFhRRnc0LXotTFdIampnRFRuTDVES3JGMkU2MUZocUNQdFc2Um9SdGZaaVBwX0pM

SkhLSFExWnpnTEtqLWpKdkhTY0R3LW42Z2drRy1CRUtuTkhyNW9hUXdqdEVfZmJuS0ljWUFUOHU5

OFkxNHZHdU1YTDlJYnptYm1tcEhXR0VkVEJrZE4tX0NUdV8wWWZic3ZPVlhtaWZ3Yko2NlVRN2JM

NU8xNWllUGctZW5WaU9IQW80YzRLU1Qwc0Q4WV81U21GbkFpYVNLT0s2YTVDclF6NGlrcUpPcTZq

Wmd4QXhOSDc0RWxULVd0cTRjeUNUbWZSRjBabjFZc0tuZUpiMVItWE9BS3FndXVLcHdVX1JNekJW

RnBEdDl4dUxFR2JwQjdLSDRtajZZWVMzY3o4SFRoMWV4QWVWSWNLZll2STQ1cExMc2ZVUDR4QXRv

THVxLUFTeFJSSjY2QVVTV1hLd0VvWGhhcWFJZ1NqRC1zNzcwWG1EeWtmc3dEMnVTR2d2WW1pQWZG

aGNVTDFqWElXY0l5UHR3OWtucC0wPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHg4MDA8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZSBDYXJsbzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+

PFJlY051bT40MDY0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+MS0zPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA2NDwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDU4MDU2Ij40MDY0PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhvcj48

YXV0aG9yPk1henpvbGFpLCBMLjwvYXV0aG9yPjxhdXRob3I+Qm9zc29uZSwgRS48L2F1dGhvcj48

YXV0aG9yPkJyb2RtYW5uLCBNLjwvYXV0aG9yPjxhdXRob3I+TWljYXJpLCBBLjwvYXV0aG9yPjxh

dXRob3I+TXVpZXNhbiwgTS4gTC48L2F1dGhvcj48YXV0aG9yPlJpY2NvLCBKLiBCLjwvYXV0aG9y

PjxhdXRob3I+U3RhYmlsZSwgRS48L2F1dGhvcj48YXV0aG9yPkFnbmVsbGksIEcuPC9hdXRob3I+

PGF1dGhvcj5BYm95YW5zLCBWLjwvYXV0aG9yPjxhdXRob3I+RS4gUy4gQy4gV29ya2luZyBHcm91

cCBvbiBBb3J0YTwvYXV0aG9yPjxhdXRob3I+UGVyaXBoZXJhbCBWYXNjdWxhciwgRGlzZWFzZXM8

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DYXJkaWFjIENh

dGhldGVyaXphdGlvbiBMYWJvcmF0b3J5LCBDYXJkaW90aG9yYWNpYyBhbmQgVmFzY3VsYXIgRGVw

YXJ0bWVudCwgQXppZW5kYSBPc3BlZGFsaWVyby1Vbml2ZXJzaXRhcmlhIFBpc2FuYSwgdmlhIFBh

cmFkaXNhIDIsIDU2MTAwIFBpc2EsIEl0YWx5LiYjeEQ7RGVwYXJ0bWVudCBvZiBBbmdpb2xvZ3ks

IExhdXNhbm5lIFVuaXZlcnNpdHkgSG9zcGl0YWwsIFJ1ZSBkdSBCdWdub24gNDYsIDEwMTEgTGF1

c2FubmUsIFN3aXR6ZXJsYW5kLiYjeEQ7Q2FyZGlvbG9neSBEaXZpc2lvbiwgJnF1b3Q7Q2F2YSBk

ZSZhcG9zOyBUaXJyZW5pIGFuZCBBbWFsZmkgQ29hc3QmcXVvdDssIEhlYXJ0IERlcGFydG1lbnQs

IFVuaXZlcnNpdHkgSG9zcGl0YWwsIFZpYSBFbnJpY28gZGUgTWFyaW5pcywgODQwMTMgQ2F2YSBk

ZSZhcG9zOyBUaXJyZW5pIChTQSksIEl0YWx5LiYjeEQ7RGl2aXNpb24gb2YgQW5naW9sb2d5LCBN

ZWRpY2FsIFVuaXZlcnNpdHkgR3JheiwgQXVlbmJydWdnZXJwbGF0eiAxNSwgODAzNiBHcmF6LCBB

dXN0cmlhLiYjeEQ7R1ZNIENhcmUgYW5kIFJlc2VhcmNoLCBNYXJpYSBDZWNpbGlhIEhvc3BpdGFs

LCB2aWEgQ29ycmllcmEgMSwgNDgwMzMgQ290aWdub2xhIChSQSksIEl0YWx5LiYjeEQ7Q2xpbmlj

YWwgYW5kIEV4cGVyaW1lbnRhbCBTY2llbmNlcyBEZXBhcnRtZW50LCBVbml2ZXJzaXR5IG9mIEJy

ZXNjaWEsIFBpYXp6YWxlIFNwZWRhbGkgQ2l2aWxpIDEsIDI1MTIzIEJyZXNjaWEsIEl0YWx5LiYj

eEQ7RGVwYXJ0bWVudCBvZiBWYXNjdWxhciBTdXJnZXJ5LCBVbml2ZXJzaXR5IEhvc3BpdGFsIG9m

IFBvaXRpZXJzLCAyIFJ1ZSBkZSBsYSBNaWxldHJpZSwgODYwMjEgUG9pdGllcnMsIEZyYW5jZS4m

I3hEO0RpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIERlcGFydG1lbnQgb2YgQWR2YW5jZWQgQmlvbWVk

aWNhbCBTY2llbmNlcywgVW5pdmVyc2l0eSBvZiBOYXBvbGkgJnF1b3Q7RmVkZXJpY28gSUkmcXVv

dDssIENvcnNvIFVtYmVydG8gSSA0MCwgODAxMzggTmFwb2xpLCBJdGFseS4mI3hEO0ludGVybmFs

IGFuZCBDYXJkaW92YXNjdWxhciBNZWRpY2luZSAtIFN0cm9rZSBVbml0LCBVbml2ZXJzaXR5IG9m

IFBlcnVnaWEsIFZpYWxlIFplZmZlcmlubyBGYWluYSA0LCAwNjEyMyBQZXJ1Z2lhLCBJdGFseS4m

I3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgRHVwdXl0cmVuIFVuaXZlcnNpdHkgSG9zcGl0

YWwsIExpbW9nZXMsIGFuZCBJbnNlcm0gMTA5NCwgVHJvcGljYWwgTmV1cm9lcGlkZW1pb2xvZ3ks

IFVuaXZlcnNpdHkgb2YgTGltb2dlcywgMzMgUnVlIEZyYW5jb2lzIE1pdHRlcnJhbmQsIDg3MDMy

IExpbW9nZXMsIEZyYW5jZS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgeWVhciBp

biBjYXJkaW9sb2d5IDIwMTY6IHBlcmlwaGVyYWwgY2lyY3VsYXRpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+MTAy

OC0xMDMzPC9wYWdlcz48dm9sdW1lPjM4PC92b2x1bWU+PG51bWJlcj4xNDwvbnVtYmVyPjxrZXl3

b3Jkcz48a2V5d29yZD5Bb3J0aWMgRGlzZWFzZXMvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+

Q2FyZGlvdmFzY3VsYXIgQWdlbnRzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5D

YXJvdGlkIEFydGVyeSBEaXNlYXNlcy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8

L2tleXdvcmQ+PGtleXdvcmQ+TGVnL2Jsb29kIHN1cHBseTwva2V5d29yZD48a2V5d29yZD5QZXJp

cGhlcmFsIFZhc2N1bGFyIERpc2Vhc2VzLyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlJhbmRv

bWl6ZWQgQ29udHJvbGxlZCBUcmlhbHMgYXMgVG9waWM8L2tleXdvcmQ+PGtleXdvcmQ+U3RlbnRz

PC9rZXl3b3JkPjxrZXl3b3JkPlZlbm91cyBUaHJvbWJvZW1ib2xpc20vKnRoZXJhcHk8L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkFw

ciA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmlj

KSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yODA0Mzk3OTwv

YWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5u

bG0ubmloLmdvdi9wdWJtZWQvMjgwNDM5Nzk8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNp

bHZlcmNoYWlyLmNvbS9laHc2NDMucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0Vy

Y3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJ

Q2FRSUJBRENDQW1JR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTVZ0WldSQ0xx

UUdhVHVaa3pBZ0VRZ0lJQ005RncxVHFHd2F4REtQalJId01ZR215eXZyTVI3dG1zTmVRWkVaNHRY

NVhuUzBGWF9vaVk2UktJZHVrRHVWSHdDZmtUSGxPQVExV08yQ0lvNk9FX1BTaGE5cHFoNDJlalZx

bkRraXVaNVdDSE9JWENoYk9DS2xCeHhwQVNmSlNudm9DWGM1bEg4dkducGxRQXVTRUg3bTR0STdS

VmdsSXdUYUFXYzV2a2doUHNwNlVPdTU1WEhvR2l1dUt2ZFF2cHRXNTZjWGYyMWJfcEV5ejFiaTRE

LU1fX3dHdFd1djBGemxUazBxR0hFX2lwbFo2X19zcEtTeEFNLW5EUnFtS3FpNXpfQmh6ejZpUmpz

QllYbVVOX2VXbDloUy0zb2Y1TFZqN0pidW80VUZ2NWlfNUVtYm1QVnJPa0NjNzRpN0szcU8wZkVO

NGw3UEgzSmlBWlRIT2JuWV9CVUNVRlVXbWtkZkl3UXpKanZXdWtLaUtmMGFDbWppZGx4T3ZYWXdC

VElWUnc3QWk1WnpNMV85bmp0TnF3R3BicC12Rmd6UlJ0YXBKVzJrYk5oN0dQakdKamhwUXpuZlFo

dG50RE11OGxnVEtZckhTMWE3SFd0cVYyRGE1WmgzRlVmNmlvampCYS1RR0lnQzBDdmVFN1hCVVFf

bHZKQk0wUFFKRmVVZHM1eUM2bnlHQXN6aWdtOUQwOXp4YTlRREdoYVkyLVZvTkI1UlBPR09SSFVa

ZEV0U0hUTVF6Y0lTamF5c2VoUHM5VnN1X1lXTzktM001NmlfLXNvSDVmLVlLQm1HWVFKQmVxTHUw

N1ZOV0p4S2tRSFlhN0tZUHF2ekpMa2FicWd3UDBaaC10NjhmSnJzM2Z6c3cwNmhZVWdNOWZINF9y

RVhlS1p5NUw0eHNIaVo1VDlnZGdKMmRzUEVwcWxsUzBoOGcwdWdmS0dOVmo1Z1ZhSWM0YkhmdmJS

d3U4UWpHeUtod1M2YXVjczgzYTVaTjdWOVJZPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHc2NDM8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkFib3lhbnM8L0F1

dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNOdW0+NDA2MjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+NDA2MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjJlYXAwMmZmanhwemFzZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDU4

MDU2Ij40MDYyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BYm95YW5z

LCBWLjwvYXV0aG9yPjxhdXRob3I+VnJzYWxvdmljLCBNLjwvYXV0aG9yPjxhdXRob3I+TWFkYXJp

YywgSi48L2F1dGhvcj48YXV0aG9yPk1henpvbGFpLCBMLjwvYXV0aG9yPjxhdXRob3I+RGUgQ2Fy

bG8sIE0uPC9hdXRob3I+PGF1dGhvcj5FLiBTLiBDLiBXb3JraW5nIEdyb3VwIG9uIEFvcnRhPC9h

dXRob3I+PGF1dGhvcj5QZXJpcGhlcmFsIFZhc2N1bGFyLCBEaXNlYXNlczwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9n

eSwgRHVwdXl0cmVuIFVuaXZlcnNpdHkgSG9zcGl0YWwsIDIsIE1hcnRpbiBMdXRoZXIgS2luZyBB

dmUsIExpbW9nZXMsIEZyYW5jZS4mI3hEO1Jlc2VhcmNoIFVuaXQgSU5TRVJNIDEwOTQsIExpbW9n

ZXMgU2Nob29sIG9mIE1lZGljaW5lLCAyLCBhdmUgTWFyY2xhbmQsIExpbW9nZXMsIEZyYW5jZS4m

I3hEO1VuaXZlcnNpdHkgb2YgWmFncmViIFNjaG9vbCBvZiBNZWRpY2luZSwgU2FsYXRhIDMsIFph

Z3JlYiwgQ3JvYXRpYS4mI3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgU2VzdHJlIE1pbG9z

cmRuaWNlIFVuaXZlcnNpdHkgSG9zcGl0YWwgQ2VudHJlLCBWaW5vZ3JhZHNrYSAyOSwgWmFncmVi

LCBDcm9hdGlhLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5IGFuZCBBbmdpb2xvZ3ksIE5h

dGlvbmFsIEluc3RpdHV0ZSBvZiBDYXJkaW92YXNjdWxhciBEaXNlYXNlcywgUG9kIEtyYXNub3Ug

aG9ya291IDEsIEJyYXRpc2xhdmEsIFNsb3Zha2lhLiYjeEQ7RGl2aXNpb24gb2YgQW5naW9sb2d5

LCBIZWFydCBhbmQgVmVzc2VsIERlcGFydG1lbnQsIExhdXNhbm5lIFVuaXZlcnNpdHkgSG9zcGl0

YWwsIFJ1ZSBkdSBCdWdub24gNDYsIExhdXNhbm5lLCBTd2l0emVybGFuZC4mI3hEO0NhcmRpYWMg

Q2F0aGV0ZXJpemF0aW9uIExhYm9yYXRvcnksIENhcmRpb3Rob3JhY2ljIGFuZCBWYXNjdWxhciBE

ZXBhcnRtZW50LCBBemllbmRhIE9zcGVkYWxpZXJvLVVuaXZlcnNpdGFyaWEgUGlzYW5hLCB2aWEg

UGFyYWRpc2EgMiwgUGlzYSwgSXRhbHkuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhl

IHllYXIgMjAxOCBpbiBjYXJkaW9sb2d5OiBhb3J0YSBhbmQgcGVyaXBoZXJhbCBjaXJjdWxhdGlv

bjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwYWdlcz44NzItODc5PC9wYWdlcz48dm9sdW1lPjQwPC92b2x1bWU+PG51bWJlcj4x

MTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyIDE0

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYj

eEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDYwMjAwNTwvYWNj

ZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0u

bmloLmdvdi9wdWJtZWQvMzA2MDIwMDU8L3VybD48dXJsPmh0dHBzOi8vYWNhZGVtaWMub3VwLmNv

bS9ldXJoZWFydGovYXJ0aWNsZS1hYnN0cmFjdC80MC8xMS84NzIvNTI2NzQ3Nj9yZWRpcmVjdGVk

RnJvbT1mdWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh5ODk5PC9lbGVjdHJvbmljLXJlc291cmNlLW51

bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5BYm95YW5zPC9BdXRob3I+PFllYXI+MjAx

ODwvWWVhcj48UmVjTnVtPjQwNjM8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQwNjM8L3Jl

Yy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHph

c2VzMnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTA1ODA1NiI+NDA2Mzwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QWJveWFucywgVi48L2F1dGhvcj48

YXV0aG9yPkJyYWVra2FuLCBTLjwvYXV0aG9yPjxhdXRob3I+TWF6em9sYWksIEwuPC9hdXRob3I+

PGF1dGhvcj5TaWxsZXNlbiwgSC48L2F1dGhvcj48YXV0aG9yPlZlbmVybW8sIE0uPC9hdXRob3I+

PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIFdvcmtpbmcgR3Jv

dXAgb24gQW9ydGE8L2F1dGhvcj48YXV0aG9yPlBlcmlwaGVyYWwgVmFzY3VsYXIsIERpc2Vhc2Vz

PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVu

dCBvZiBDYXJkaW9sb2d5LCBEdXB1eXRyZW4gVW5pdmVyc2l0eSBIb3NwaXRhbCwgMiwgTWFydGlu

IEx1dGhlciBLaW5nIEF2ZS4sIExpbW9nZXMsIEZyYW5jZS4mI3hEO0luc2VybSAxMDk0LCBMaW1v

Z2VzIFNjaG9vbCBvZiBNZWRpY2luZSwgQXZlIERyLiBNYXJjbGFuZCwgODcwMjUgTGltb2dlcywg

RnJhbmNlLiYjeEQ7Sy5HLiBKZWJzZW4gVGhyb21ib3NpcyBSZXNlYXJjaCBhbmQgRXhwZXJ0aXNl

IENlbnRlciAoVFJFQyksIERlcGFydG1lbnQgb2YgQ2xpbmljYWwgTWVkaWNpbmUsIFVpVCAtIFRo

ZSBBcmN0aWMgVW5pdmVyc2l0eSBvZiBOb3J3YXksIEhhbnNpbmUgSGFuc2VucyB2ZWcgMTgsIDkw

MzcsIFRyb21zbywgTm9yd2F5LiYjeEQ7RGl2aXNpb24gb2YgQW5naW9sb2d5LCBEZXBhcnRtZW50

IG9mIEhlYXJ0IGFuZCBWZXNzZWwsIExhdXNhbm5lIFVuaXZlcnNpdHkgSG9zcGl0YWwsIENoIGR1

IE1vbnQtUGFpc2libGUgMTgsIExhdXNhbm5lLCAxMDExLCBTd2l0emVybGFuZC4mI3hEO0RlcGFy

dG1lbnQgb2YgVmFzY3VsYXIgU3VyZ2VyeSwgUmlnc2hvc3BpdGFsZXQsIFVuaXZlcnNpdHkgb2Yg

Q29wZW5oYWdlbiwgQmxlZ2RhbXN2ZWogOSwgQ29wZW5oYWdlbiwgMjEwMCwgRGVubWFyay4mI3hE

O0RlcGFydG1lbnQgb2YgVmFzY3VsYXIgU3VyZ2VyeSwgSGVsc2lua2kgVW5pdmVyc2l0eSBIb3Nw

aXRhbCwgSGFhcnRtYW5pbmthdHUgNCwgRkktMDAyOTAgSGVsc2lua2ksIEZpbmxhbmQuJiN4RDtD

YXJkaWFjIENhdGhldGVyaXphdGlvbiBMYWJvcmF0b3J5LCBDYXJkaW90aG9yYWNpYyBhbmQgVmFz

Y3VsYXIgRGVwYXJ0bWVudCwgQXppZW5kYSBPc3BlYWxpZXJvLVVuaXZlcnNpdGFyaWEgUGlzYW5h

LCB2aWEgUGFyYWRpc2EsIFBpc2EsIEl0YWx5LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PlRoZSB5ZWFyIDIwMTcgaW4gY2FyZGlvbG9neTogYW9ydGEgYW5kIHBlcmlwaGVyYWwgY2lyY3Vs

YXRpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+NzMwLTczODwvcGFnZXM+PHZvbHVtZT4zOTwvdm9sdW1lPjxudW1i

ZXI+OTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFy

IDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMp

JiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI5MzAwODY4PC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3B1Ym1lZC8yOTMwMDg2ODwvdXJsPjx1cmw+aHR0cHM6Ly93YXRlcm1hcmsuc2ls

dmVyY2hhaXIuY29tL2VoeDgwMC5wZGY/dG9rZW49QVFFQ0FIaTIwOEJFNDlPb2FuOWtraFdfRXJj

eTdEbTNaTF85Q2YzcWZLQWM0ODV5c2dBQUFud3dnZ0o0QmdrcWhraUc5dzBCQndhZ2dnSnBNSUlD

WlFJQkFEQ0NBbDRHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFNRUFTNHdFUVFNWFNCSHFNUXVz

ejFFOVhTX0FnRVFnSUlDTDBjWFBBVFZNbVZKUUJfQmFvYUhBVnhpd2luUTNYZ1piQW53dkNEMTVz

dFc5UXhKVlZablZwQWQxNXdLVUU4eTdqeEV5V0RKMUJVLWhqQk5HQ2RiNmdDN2FqSFRUWGRmajI1

clZLU2s3akhfWVdsU2MyT2l6R1k3WGFxOGlMd0tHVWNUMWN6MUg4aU9qMHN4bU9kSTF6Wm5nUlA0

S1JPNC1JQTBDc0ZXR0U2VzhqdWNHcm1DazhMOXZ1UXNraUF5ZTN6V3NoUHlab3duWXZySWRVY29C

NlhMRGwyaWFDaFhJV0tBMzlNTVhsRnk3Q0NSc0x5TnVNYVBkZHgzZEp2LTlRSmhaZmdrZjVwLWNv

YV9nUTZ1X1c4a1dfS3ljbFB6ZGFFbHlMelE4aE1fMDU0NHhERE5wYktGOFJsNWhVWGpFenFPMEct

Y1V0VkowcFg0eFhRRnc0LXotTFdIampnRFRuTDVES3JGMkU2MUZocUNQdFc2Um9SdGZaaVBwX0pM

SkhLSFExWnpnTEtqLWpKdkhTY0R3LW42Z2drRy1CRUtuTkhyNW9hUXdqdEVfZmJuS0ljWUFUOHU5

OFkxNHZHdU1YTDlJYnptYm1tcEhXR0VkVEJrZE4tX0NUdV8wWWZic3ZPVlhtaWZ3Yko2NlVRN2JM

NU8xNWllUGctZW5WaU9IQW80YzRLU1Qwc0Q4WV81U21GbkFpYVNLT0s2YTVDclF6NGlrcUpPcTZq

Wmd4QXhOSDc0RWxULVd0cTRjeUNUbWZSRjBabjFZc0tuZUpiMVItWE9BS3FndXVLcHdVX1JNekJW

RnBEdDl4dUxFR2JwQjdLSDRtajZZWVMzY3o4SFRoMWV4QWVWSWNLZll2STQ1cExMc2ZVUDR4QXRv

THVxLUFTeFJSSjY2QVVTV1hLd0VvWGhhcWFJZ1NqRC1zNzcwWG1EeWtmc3dEMnVTR2d2WW1pQWZG

aGNVTDFqWElXY0l5UHR3OWtucC0wPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHg4MDA8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA 1-3 the current article reviews ground breaking science published 2019 in the area of aortic and peripheral arterial diseases (PAD) as well as venous thromboembolic disease (VTE) that will affect our daily clinical practise. With the growing recognition of PAD, it will be necessary to consolidate imprecisions in terminology. Formerly many of us are used to the acronym PAD for atherosclerotic disease of the lower extremity arteries. Others have used the same acronym to qualify atherosclerotic disease of the lower extremities arteries and carotid arteries. In the current article and in line with the ESC guidelines,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYm95YW5zPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48

UmVjTnVtPjM2MTY8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij40PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MzYxNjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMy

cjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTI1MDg0MzQwIj4zNjE2PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BYm95YW5zLCBWLjwvYXV0aG9yPjxhdXRo

b3I+UmljY28sIEouIEIuPC9hdXRob3I+PGF1dGhvcj5CYXJ0ZWxpbmssIE0uIEUuIEwuPC9hdXRo

b3I+PGF1dGhvcj5Cam9yY2ssIE0uPC9hdXRob3I+PGF1dGhvcj5Ccm9kbWFubiwgTS48L2F1dGhv

cj48YXV0aG9yPkNvaG5lcnQsIFQuPC9hdXRob3I+PGF1dGhvcj5Db2xsZXQsIEouIFAuPC9hdXRo

b3I+PGF1dGhvcj5DemVybnksIE0uPC9hdXRob3I+PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhv

cj48YXV0aG9yPkRlYnVzLCBTLjwvYXV0aG9yPjxhdXRob3I+RXNwaW5vbGEtS2xlaW4sIEMuPC9h

dXRob3I+PGF1dGhvcj5LYWhhbiwgVC48L2F1dGhvcj48YXV0aG9yPktvd25hdG9yLCBTLjwvYXV0

aG9yPjxhdXRob3I+TWF6em9sYWksIEwuPC9hdXRob3I+PGF1dGhvcj5OYXlsb3IsIEEuIFIuPC9h

dXRob3I+PGF1dGhvcj5Sb2ZmaSwgTS48L2F1dGhvcj48YXV0aG9yPlJvdGhlciwgSi48L2F1dGhv

cj48YXV0aG9yPlNwcnluZ2VyLCBNLjwvYXV0aG9yPjxhdXRob3I+VGVuZGVyYSwgTS48L2F1dGhv

cj48YXV0aG9yPlRlcGUsIEcuPC9hdXRob3I+PGF1dGhvcj5WZW5lcm1vLCBNLjwvYXV0aG9yPjxh

dXRob3I+VmxhY2hvcG91bG9zLCBDLjwvYXV0aG9yPjxhdXRob3I+RGVzb3JtYWlzLCBJLjwvYXV0

aG9yPjxhdXRob3I+RS4gUy4gQy4gU2NpZW50aWZpYyBEb2N1bWVudCBHcm91cDwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE3IEVTQyBHdWlkZWxpbmVz

IG9uIHRoZSBEaWFnbm9zaXMgYW5kIFRyZWF0bWVudCBvZiBQZXJpcGhlcmFsIEFydGVyaWFsIERp

c2Vhc2VzLCBpbiBjb2xsYWJvcmF0aW9uIHdpdGggdGhlIEV1cm9wZWFuIFNvY2lldHkgZm9yIFZh

c2N1bGFyIFN1cmdlcnkgKEVTVlMpOiBEb2N1bWVudCBjb3ZlcmluZyBhdGhlcm9zY2xlcm90aWMg

ZGlzZWFzZSBvZiBleHRyYWNyYW5pYWwgY2Fyb3RpZCBhbmQgdmVydGVicmFsLCBtZXNlbnRlcmlj

LCByZW5hbCwgdXBwZXIgYW5kIGxvd2VyIGV4dHJlbWl0eSBhcnRlcmllc0VuZG9yc2VkIGJ5OiB0

aGUgRXVyb3BlYW4gU3Ryb2tlIE9yZ2FuaXphdGlvbiAoRVNPKVRoZSBUYXNrIEZvcmNlIGZvciB0

aGUgRGlhZ25vc2lzIGFuZCBUcmVhdG1lbnQgb2YgUGVyaXBoZXJhbCBBcnRlcmlhbCBEaXNlYXNl

cyBvZiB0aGUgRXVyb3BlYW4gU29jaWV0eSBvZiBDYXJkaW9sb2d5IChFU0MpIGFuZCBvZiB0aGUg

RXVyb3BlYW4gU29jaWV0eSBmb3IgVmFzY3VsYXIgU3VyZ2VyeSAoRVNWUyk8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1cm9w

ZWFuIGhlYXJ0IGpvdXJuYWw8L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+NzYzLTgxNjwvcGFn

ZXM+PHZvbHVtZT4zOTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE4

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48

aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjI4ODg2NjIwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI4ODg2NjIwPC91cmw+

PHVybD5odHRwczovL3dhdGVybWFyay5zaWx2ZXJjaGFpci5jb20vZWh4MDk1LnBkZj90b2tlbj1B

UUVDQUhpMjA4QkU0OU9vYW45a2toV19FcmN5N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQWNVd2dn

SEJCZ2txaGtpRzl3MEJCd2FnZ2dHeU1JSUJyZ0lCQURDQ0FhY0dDU3FHU0liM0RRRUhBVEFlQmds

Z2hrZ0JaUU1FQVM0d0VRUU1iY0Z6c081eWFfOWJIUlFCQWdFUWdJSUJlRjNmd2wxMGNIOU9pbFZR

VVJ5ZGcyTFVtT3hQdk1OcE1KdW4zdFM4MmVocnBheEZoZXFFa1hJOW9HT1FiZzRwVlgxSWpFTm15

LXNOLUd1Z0NxZDdFZDNqbF82R1RCd0t1aXJxdEpsWjZSc1ZfNG1DOE9qb21nOFZ4cGhzVWZMcWN0

bEZwZ29hVUNiVDlsQUNMbkNYajZfam1wbWc3Y3dqb005SldMRExEWTEzNmgzY2cwMDRxN1B6dW9y

clZidEJSbmNldjNFNlgwVXFPck5PY19xaXZoQUgwU2VFd1RvTF9jVTQ0dld3M3NXbkhBWlQ1YnRL

akx4Wm0yZWUzQmlNdjRJVGIyTE1vckpkZW90SFRsNXY1SWpxcFJlQ2hBcjY3LUd6NEo1NUlYX19K

dEdkdUF2bkNld0hWckpiWVVCRlc3UXFvckFJbGNzX19JNDdGYTJ5QkszV3VQN1BXbTBWTm4yXzBk

bHVvTFh2c2ktNE1vdTc3TWR2ZXVRb2pSN2RQS09WWk14Y1Rwb3diOVE5NUFYSzcxc05NcXhXMkg5

cHBUejd6aTk3T3ZDbEI5N24yZUk1alNsZkxYLVdYNEdYSGZwYlpsQXJ2UVBLS1lLbXpQUDNyZXBK

ckRKMm9XLU8tdGlWYm16MnlkbHM4LWM4TDRHZXJoczwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh4MDk1PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYm95YW5zPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48

UmVjTnVtPjM2MTY8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij40PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MzYxNjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMy

cjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTI1MDg0MzQwIj4zNjE2PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BYm95YW5zLCBWLjwvYXV0aG9yPjxhdXRo

b3I+UmljY28sIEouIEIuPC9hdXRob3I+PGF1dGhvcj5CYXJ0ZWxpbmssIE0uIEUuIEwuPC9hdXRo

b3I+PGF1dGhvcj5Cam9yY2ssIE0uPC9hdXRob3I+PGF1dGhvcj5Ccm9kbWFubiwgTS48L2F1dGhv

cj48YXV0aG9yPkNvaG5lcnQsIFQuPC9hdXRob3I+PGF1dGhvcj5Db2xsZXQsIEouIFAuPC9hdXRo

b3I+PGF1dGhvcj5DemVybnksIE0uPC9hdXRob3I+PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhv

cj48YXV0aG9yPkRlYnVzLCBTLjwvYXV0aG9yPjxhdXRob3I+RXNwaW5vbGEtS2xlaW4sIEMuPC9h

dXRob3I+PGF1dGhvcj5LYWhhbiwgVC48L2F1dGhvcj48YXV0aG9yPktvd25hdG9yLCBTLjwvYXV0

aG9yPjxhdXRob3I+TWF6em9sYWksIEwuPC9hdXRob3I+PGF1dGhvcj5OYXlsb3IsIEEuIFIuPC9h

dXRob3I+PGF1dGhvcj5Sb2ZmaSwgTS48L2F1dGhvcj48YXV0aG9yPlJvdGhlciwgSi48L2F1dGhv

cj48YXV0aG9yPlNwcnluZ2VyLCBNLjwvYXV0aG9yPjxhdXRob3I+VGVuZGVyYSwgTS48L2F1dGhv

cj48YXV0aG9yPlRlcGUsIEcuPC9hdXRob3I+PGF1dGhvcj5WZW5lcm1vLCBNLjwvYXV0aG9yPjxh

dXRob3I+VmxhY2hvcG91bG9zLCBDLjwvYXV0aG9yPjxhdXRob3I+RGVzb3JtYWlzLCBJLjwvYXV0

aG9yPjxhdXRob3I+RS4gUy4gQy4gU2NpZW50aWZpYyBEb2N1bWVudCBHcm91cDwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE3IEVTQyBHdWlkZWxpbmVz

IG9uIHRoZSBEaWFnbm9zaXMgYW5kIFRyZWF0bWVudCBvZiBQZXJpcGhlcmFsIEFydGVyaWFsIERp

c2Vhc2VzLCBpbiBjb2xsYWJvcmF0aW9uIHdpdGggdGhlIEV1cm9wZWFuIFNvY2lldHkgZm9yIFZh

c2N1bGFyIFN1cmdlcnkgKEVTVlMpOiBEb2N1bWVudCBjb3ZlcmluZyBhdGhlcm9zY2xlcm90aWMg

ZGlzZWFzZSBvZiBleHRyYWNyYW5pYWwgY2Fyb3RpZCBhbmQgdmVydGVicmFsLCBtZXNlbnRlcmlj

LCByZW5hbCwgdXBwZXIgYW5kIGxvd2VyIGV4dHJlbWl0eSBhcnRlcmllc0VuZG9yc2VkIGJ5OiB0

aGUgRXVyb3BlYW4gU3Ryb2tlIE9yZ2FuaXphdGlvbiAoRVNPKVRoZSBUYXNrIEZvcmNlIGZvciB0

aGUgRGlhZ25vc2lzIGFuZCBUcmVhdG1lbnQgb2YgUGVyaXBoZXJhbCBBcnRlcmlhbCBEaXNlYXNl

cyBvZiB0aGUgRXVyb3BlYW4gU29jaWV0eSBvZiBDYXJkaW9sb2d5IChFU0MpIGFuZCBvZiB0aGUg

RXVyb3BlYW4gU29jaWV0eSBmb3IgVmFzY3VsYXIgU3VyZ2VyeSAoRVNWUyk8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1cm9w

ZWFuIGhlYXJ0IGpvdXJuYWw8L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+NzYzLTgxNjwvcGFn

ZXM+PHZvbHVtZT4zOTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE4

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48

aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjI4ODg2NjIwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI4ODg2NjIwPC91cmw+

PHVybD5odHRwczovL3dhdGVybWFyay5zaWx2ZXJjaGFpci5jb20vZWh4MDk1LnBkZj90b2tlbj1B

UUVDQUhpMjA4QkU0OU9vYW45a2toV19FcmN5N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQWNVd2dn

SEJCZ2txaGtpRzl3MEJCd2FnZ2dHeU1JSUJyZ0lCQURDQ0FhY0dDU3FHU0liM0RRRUhBVEFlQmds

Z2hrZ0JaUU1FQVM0d0VRUU1iY0Z6c081eWFfOWJIUlFCQWdFUWdJSUJlRjNmd2wxMGNIOU9pbFZR

VVJ5ZGcyTFVtT3hQdk1OcE1KdW4zdFM4MmVocnBheEZoZXFFa1hJOW9HT1FiZzRwVlgxSWpFTm15

LXNOLUd1Z0NxZDdFZDNqbF82R1RCd0t1aXJxdEpsWjZSc1ZfNG1DOE9qb21nOFZ4cGhzVWZMcWN0

bEZwZ29hVUNiVDlsQUNMbkNYajZfam1wbWc3Y3dqb005SldMRExEWTEzNmgzY2cwMDRxN1B6dW9y

clZidEJSbmNldjNFNlgwVXFPck5PY19xaXZoQUgwU2VFd1RvTF9jVTQ0dld3M3NXbkhBWlQ1YnRL

akx4Wm0yZWUzQmlNdjRJVGIyTE1vckpkZW90SFRsNXY1SWpxcFJlQ2hBcjY3LUd6NEo1NUlYX19K

dEdkdUF2bkNld0hWckpiWVVCRlc3UXFvckFJbGNzX19JNDdGYTJ5QkszV3VQN1BXbTBWTm4yXzBk

bHVvTFh2c2ktNE1vdTc3TWR2ZXVRb2pSN2RQS09WWk14Y1Rwb3diOVE5NUFYSzcxc05NcXhXMkg5

cHBUejd6aTk3T3ZDbEI5N24yZUk1alNsZkxYLVdYNEdYSGZwYlpsQXJ2UVBLS1lLbXpQUDNyZXBK

ckRKMm9XLU8tdGlWYm16MnlkbHM4LWM4TDRHZXJoczwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh4MDk1PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA 4 we have stringently used the specific terms lower extremity arterial disease (LEAD) and reserved PAD as the umbrella term encompassing all arterial diseases other than aorta and coronaries. Vascular biology/translational research The extent to which genetic factors contribute to PAD development and if they are shared or distinct between LEAD, cerebral, and coronary arteries is largely unknown. In a genome-wide association study in the Million Veteran Program, ~32 million DNA sequence variants were tested for PAD (31,307 cases, 211,753 controls) and combined with electronic health records.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbGFyaW48L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxS

ZWNOdW0+NDA2NzwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi

PjU8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDY3PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkwNjA0NzMiPjQwNjc8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktsYXJpbiwgRC48L2F1dGhvcj48YXV0aG9y

Pkx5bmNoLCBKLjwvYXV0aG9yPjxhdXRob3I+QXJhZ2FtLCBLLjwvYXV0aG9yPjxhdXRob3I+Q2hh

ZmZpbiwgTS48L2F1dGhvcj48YXV0aG9yPkFzc2ltZXMsIFQuIEwuPC9hdXRob3I+PGF1dGhvcj5I

dWFuZywgSi48L2F1dGhvcj48YXV0aG9yPkxlZSwgSy4gTS48L2F1dGhvcj48YXV0aG9yPlNoYW8s

IFEuPC9hdXRob3I+PGF1dGhvcj5IdWZmbWFuLCBKLiBFLjwvYXV0aG9yPjxhdXRob3I+TmF0YXJh

amFuLCBQLjwvYXV0aG9yPjxhdXRob3I+QXJ5YSwgUy48L2F1dGhvcj48YXV0aG9yPlNtYWxsLCBB

LjwvYXV0aG9yPjxhdXRob3I+U3VuLCBZLiBWLjwvYXV0aG9yPjxhdXRob3I+VnVqa292aWMsIE0u

PC9hdXRob3I+PGF1dGhvcj5GcmVpYmVyZywgTS4gUy48L2F1dGhvcj48YXV0aG9yPldhbmcsIEwu

PC9hdXRob3I+PGF1dGhvcj5DaGVuLCBKLjwvYXV0aG9yPjxhdXRob3I+U2FsZWhlZW4sIEQuPC9h

dXRob3I+PGF1dGhvcj5MZWUsIEouIFMuPC9hdXRob3I+PGF1dGhvcj5NaWxsZXIsIEQuIFIuPC9h

dXRob3I+PGF1dGhvcj5SZWF2ZW4sIFAuPC9hdXRob3I+PGF1dGhvcj5BbGJhLCBQLiBSLjwvYXV0

aG9yPjxhdXRob3I+UGF0dGVyc29uLCBPLiBWLjwvYXV0aG9yPjxhdXRob3I+RHVWYWxsLCBTLiBM

LjwvYXV0aG9yPjxhdXRob3I+Qm9kZW4sIFcuIEUuPC9hdXRob3I+PGF1dGhvcj5CZWNrbWFuLCBK

LiBBLjwvYXV0aG9yPjxhdXRob3I+R2F6aWFubywgSi4gTS48L2F1dGhvcj48YXV0aG9yPkNvbmNh

dG8sIEouPC9hdXRob3I+PGF1dGhvcj5SYWRlciwgRC4gSi48L2F1dGhvcj48YXV0aG9yPkNobywg

Sy48L2F1dGhvcj48YXV0aG9yPkNoYW5nLCBLLiBNLjwvYXV0aG9yPjxhdXRob3I+V2lsc29uLCBQ

LiBXLiBGLjwvYXV0aG9yPjxhdXRob3I+TyZhcG9zO0Rvbm5lbGwsIEMuIEouPC9hdXRob3I+PGF1

dGhvcj5LYXRoaXJlc2FuLCBTLjwvYXV0aG9yPjxhdXRob3I+Vi4gQS4gTWlsbGlvbiBWZXRlcmFu

IFByb2dyYW08L2F1dGhvcj48YXV0aG9yPlRzYW8sIFAuIFMuPC9hdXRob3I+PGF1dGhvcj5EYW1y

YXVlciwgUy4gTS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5Cb3N0b24gVkEgSGVhbHRoY2FyZSBTeXN0ZW0sIEJvc3RvbiwgTUEsIFVTQS4mI3hEO0NlbnRl

ciBmb3IgR2Vub21pYyBNZWRpY2luZSwgTWFzc2FjaHVzZXR0cyBHZW5lcmFsIEhvc3BpdGFsLCBI

YXJ2YXJkIE1lZGljYWwgU2Nob29sLCBCb3N0b24sIE1BLCBVU0EuJiN4RDtQcm9ncmFtIGluIE1l

ZGljYWwgYW5kIFBvcHVsYXRpb24gR2VuZXRpY3MsIEJyb2FkIEluc3RpdHV0ZSBvZiBNSVQgYW5k

IEhhcnZhcmQsIENhbWJyaWRnZSwgTUEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgU3VyZ2VyeSwg

TWFzc2FjaHVzZXR0cyBHZW5lcmFsIEhvc3BpdGFsLCBCb3N0b24sIE1BLCBVU0EuJiN4RDtWQSBJ

bmZvcm1hdGljcyBhbmQgQ29tcHV0aW5nIEluZnJhc3RydWN0dXJlLCBEZXBhcnRtZW50IG9mIFZl

dGVyYW5zIEFmZmFpcnMsIFNhbHQgTGFrZSBDaXR5IEhlYWx0aCBDYXJlIFN5c3RlbSwgU2FsdCBM

YWtlIENpdHksIENULCBVU0EuJiN4RDtVbml2ZXJzaXR5IG9mIE1hc3NhY2h1c2V0dHMgQ29sbGVn

ZSBvZiBOdXJzaW5nICZhbXA7IEhlYWx0aCBTY2llbmNlcywgQm9zdG9uLCBNQSwgVVNBLiYjeEQ7

Q2VudGVyIGZvciBIZWFsdGhjYXJlIE9yZ2FuaXphdGlvbiBhbmQgSW1wbGVtZW50YXRpb24gUmVz

ZWFyY2gsIEVkaXRoIE5vdXJzZSBSb2dlcnMgTWVtb3JpYWwgVkEgSG9zcGl0YWwsIEJlZGZvcmQs

IE1BLCBVU0EuJiN4RDtWQSBQYWxvIEFsdG8gSGVhbHRoIENhcmUgU3lzdGVtLCBQYWxvIEFsdG8s

IENBLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBTdGFuZm9yZCBVbml2ZXJzaXR5

IFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQsIENBLCBVU0EuJiN4RDtNYXNzYWNodXNldHRz

IFZldGVyYW5zIEVwaWRlbWlvbG9neSBSZXNlYXJjaCBhbmQgSW5mb3JtYXRpb24gQ2VudGVyLCBW

QSBCb3N0b24gSGVhbHRoY2FyZSBTeXN0ZW0sIEJvc3RvbiwgTUEsIFVTQS4mI3hEO0RlcGFydG1l

bnQgb2YgSGVhbHRoIExhdywgUG9saWN5ICZhbXA7IE1hbmFnZW1lbnQsIEJvc3RvbiBVbml2ZXJz

aXR5IFNjaG9vbCBvZiBQdWJsaWMgSGVhbHRoLCBCb3N0b24sIE1BLCBVU0EuJiN4RDtDYXJkaW92

YXNjdWxhciBSZXNlYXJjaCBDZW50ZXIsIE1hc3NhY2h1c2V0dHMgR2VuZXJhbCBIb3NwaXRhbCwg

Qm9zdG9uLCBNQSwgVVNBLiYjeEQ7RGVwYXJ0bWVudCBvZiBTdXJnZXJ5LCBTdGFuZm9yZCBVbml2

ZXJzaXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQsIENBLCBVU0EuJiN4RDtDb3Jwb3Jh

bCBNaWNoYWVsIEouIENyZXNjZW56IFZBIE1lZGljYWwgQ2VudGVyLCBQaGlsYWRlbHBoaWEsIFBB

LCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBZYWxlIFVuaXZlcnNpdHkgU2Nob29s

IG9mIE1lZGljaW5lLCBOZXcgSGF2ZW4sIENULCBVU0EuJiN4RDtBdGxhbnRhIFZBIEhlYWx0aCBD

YXJlIFN5c3RlbSwgRGVjYXR1ciwgR0EsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgRXBpZGVtaW9s

b2d5LCBFbW9yeSBVbml2ZXJzaXR5IFJvbGxpbnMgU2Nob29sIG9mIFB1YmxpYyBIZWFsdGgsIEVt

b3J5IFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBBdGxhbnRhLCBHQSwgVVNBLiYjeEQ7

RGVwYXJ0bWVudCBvZiBCaW9tZWRpY2FsIEluZm9ybWF0aWNzLCBFbW9yeSBVbml2ZXJzaXR5IFNj

aG9vbCBvZiBNZWRpY2luZSwgQXRsYW50YSwgR0EsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgQmlv

c3RhdGlzdGljcywgRXBpZGVtaW9sb2d5LCBhbmQgSW5mb3JtYXRpY3MsIFBlcmVsbWFuIFNjaG9v

bCBvZiBNZWRpY2luZSwgUGhpbGFkZWxwaGlhLCBQQSwgVVNBLiYjeEQ7VkEgVGVubmVzc2VlIFZh

bGxleSBIZWFsdGhjYXJlIFN5c3RlbSwgTmFzaHZpbGxlLCBUTiwgVVNBLiYjeEQ7VmFuZGVyYmls

dCBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBOYXNodmlsbGUsIFROLCBVU0EuJiN4RDtDZW50

ZXIgZm9yIEhlYWx0aGNhcmUgT3JnYW5pemF0aW9uIGFuZCBJbXBsZW1lbnRhdGlvbiBSZXNlYXJj

aCwgRWRpdGggTm91cnNlIFJvZ2VycyBNZW1vcmlhbCBWZXRlcmFucyBIb3NwaXRhbCwgQmVkZm9y

ZCwgTUEsIFVTQS4mI3hEO0Jvc3RvbiBVbml2ZXJzaXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgQm9z

dG9uLCBNQSwgVVNBLiYjeEQ7UGhvZW5peCBWZXRlcmFucyBBZmZhaXJzIEhlYWx0aCBDYXJlIFN5

c3RlbSwgUGhvZW5peCwgQVosIFVTQS4mI3hEO0RpdmlzaW9uIG9mIEVwaWRlbWlvbG9neSwgRGVw

YXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBVdGFoIFNjaG9vbCBv

ZiBNZWRpY2luZSwgU2FsdCBMYWtlIENpdHksIFVULCBVU0EuJiN4RDtDYXJkaW92YXNjdWxhciBE

aXZpc2lvbiwgVmFuZGVyYmlsdCBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBOYXNodmlsbGUs

IFROLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZh

cG9zO3MgSG9zcGl0YWwsIEhhcnZhcmQgTWVkaWNhbCBTY2hvb2wsIEJvc3RvbiwgTUEsIFVTQS4m

I3hEO0NsaW5pY2FsIEVwaWRlbWlvbG9neSBSZXNlYXJjaCBDZW50ZXIsIFZBIENvbm5lY3RpY3V0

IEhlYWx0aGNhcmUgU3lzdGVtLCBXZXN0IEhhdmVuLCBDVCwgVVNBLiYjeEQ7Q2VudGVyIGZvciBE

cnVnIEV2YWx1YXRpb24gYW5kIFJlc2VhcmNoLCBVUyBGb29kIGFuZCBEcnVnIEFkbWluaXN0cmF0

aW9uLCBTaWx2ZXIgU3ByaW5nLCBNRCwgVVNBLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwg

UGVybG1hbiBTY2hvb2wgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgb2YgUGVubnN5bHZhbmlhLCBQ

aGlsYWRlbHBoaWEsIFBBLCBVU0EuJiN4RDtFbW9yeSBDbGluaWNhbCBDYXJkaW92YXNjdWxhciBS

ZXNlYXJjaCBJbnN0aXR1dGUsIEF0bGFudGEsIEdBLCBVU0EuJiN4RDtDYXJkaW92YXNjdWxhciBN

ZWRpY2luZSBEaXZpc2lvbiwgRGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgQnJpZ2hhbSBhbmQgV29t

ZW4mYXBvcztzIEhvc3BpdGFsLCBIYXJ2YXJkIE1lZGljYWwgU2Nob29sLCBCb3N0b24sIE1BLCBV

U0EuJiN4RDtDb3Jwb3JhbCBNaWNoYWVsIEouIENyZXNjZW56IFZBIE1lZGljYWwgQ2VudGVyLCBQ

aGlsYWRlbHBoaWEsIFBBLCBVU0EuIGRhbXJhdWVyQHVwZW5uLmVkdS4mI3hEO0RlcGFydG1lbnQg

b2YgU3VyZ2VyeSwgUGVybG1hbiBTY2hvb2wgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgb2YgUGVu

bnN5bHZhbmlhLCBQaGlsYWRlbHBoaWEsIFBBLCBVU0EuIGRhbXJhdWVyQHVwZW5uLmVkdS48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HZW5vbWUtd2lkZSBhc3NvY2lhdGlvbiBzdHVkeSBv

ZiBwZXJpcGhlcmFsIGFydGVyeSBkaXNlYXNlIGluIHRoZSBNaWxsaW9uIFZldGVyYW4gUHJvZ3Jh

bTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OYXQgTWVkPC9zZWNvbmRhcnktdGl0bGU+PC90aXRs

ZXM+PHBhZ2VzPjEyNzQtMTI3OTwvcGFnZXM+PHZvbHVtZT4yNTwvdm9sdW1lPjxudW1iZXI+ODwv

bnVtYmVyPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnPC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU0Ni0xNzBYIChFbGVjdHJvbmljKSYjeEQ7MTA3

OC04OTU2IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMTI4NTYzMjwvYWNjZXNzaW9u

LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMzEyODU2MzI8L3VybD48dXJsPmh0dHBzOi8vd3d3Lm5hdHVyZS5jb20vYXJ0aWNs

ZXMvczQxNTkxLTAxOS0wNDkyLTUucGRmPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj

dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDM4L3M0MTU5MS0wMTktMDQ5Mi01PC9lbGVjdHJvbmlj

LXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbGFyaW48L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxS

ZWNOdW0+NDA2NzwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi

PjU8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDY3PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkwNjA0NzMiPjQwNjc8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktsYXJpbiwgRC48L2F1dGhvcj48YXV0aG9y

Pkx5bmNoLCBKLjwvYXV0aG9yPjxhdXRob3I+QXJhZ2FtLCBLLjwvYXV0aG9yPjxhdXRob3I+Q2hh

ZmZpbiwgTS48L2F1dGhvcj48YXV0aG9yPkFzc2ltZXMsIFQuIEwuPC9hdXRob3I+PGF1dGhvcj5I

dWFuZywgSi48L2F1dGhvcj48YXV0aG9yPkxlZSwgSy4gTS48L2F1dGhvcj48YXV0aG9yPlNoYW8s

IFEuPC9hdXRob3I+PGF1dGhvcj5IdWZmbWFuLCBKLiBFLjwvYXV0aG9yPjxhdXRob3I+TmF0YXJh

amFuLCBQLjwvYXV0aG9yPjxhdXRob3I+QXJ5YSwgUy48L2F1dGhvcj48YXV0aG9yPlNtYWxsLCBB

LjwvYXV0aG9yPjxhdXRob3I+U3VuLCBZLiBWLjwvYXV0aG9yPjxhdXRob3I+VnVqa292aWMsIE0u

PC9hdXRob3I+PGF1dGhvcj5GcmVpYmVyZywgTS4gUy48L2F1dGhvcj48YXV0aG9yPldhbmcsIEwu

PC9hdXRob3I+PGF1dGhvcj5DaGVuLCBKLjwvYXV0aG9yPjxhdXRob3I+U2FsZWhlZW4sIEQuPC9h

dXRob3I+PGF1dGhvcj5MZWUsIEouIFMuPC9hdXRob3I+PGF1dGhvcj5NaWxsZXIsIEQuIFIuPC9h

dXRob3I+PGF1dGhvcj5SZWF2ZW4sIFAuPC9hdXRob3I+PGF1dGhvcj5BbGJhLCBQLiBSLjwvYXV0

aG9yPjxhdXRob3I+UGF0dGVyc29uLCBPLiBWLjwvYXV0aG9yPjxhdXRob3I+RHVWYWxsLCBTLiBM

LjwvYXV0aG9yPjxhdXRob3I+Qm9kZW4sIFcuIEUuPC9hdXRob3I+PGF1dGhvcj5CZWNrbWFuLCBK

LiBBLjwvYXV0aG9yPjxhdXRob3I+R2F6aWFubywgSi4gTS48L2F1dGhvcj48YXV0aG9yPkNvbmNh

dG8sIEouPC9hdXRob3I+PGF1dGhvcj5SYWRlciwgRC4gSi48L2F1dGhvcj48YXV0aG9yPkNobywg

Sy48L2F1dGhvcj48YXV0aG9yPkNoYW5nLCBLLiBNLjwvYXV0aG9yPjxhdXRob3I+V2lsc29uLCBQ

LiBXLiBGLjwvYXV0aG9yPjxhdXRob3I+TyZhcG9zO0Rvbm5lbGwsIEMuIEouPC9hdXRob3I+PGF1

dGhvcj5LYXRoaXJlc2FuLCBTLjwvYXV0aG9yPjxhdXRob3I+Vi4gQS4gTWlsbGlvbiBWZXRlcmFu

IFByb2dyYW08L2F1dGhvcj48YXV0aG9yPlRzYW8sIFAuIFMuPC9hdXRob3I+PGF1dGhvcj5EYW1y

YXVlciwgUy4gTS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5Cb3N0b24gVkEgSGVhbHRoY2FyZSBTeXN0ZW0sIEJvc3RvbiwgTUEsIFVTQS4mI3hEO0NlbnRl

ciBmb3IgR2Vub21pYyBNZWRpY2luZSwgTWFzc2FjaHVzZXR0cyBHZW5lcmFsIEhvc3BpdGFsLCBI

YXJ2YXJkIE1lZGljYWwgU2Nob29sLCBCb3N0b24sIE1BLCBVU0EuJiN4RDtQcm9ncmFtIGluIE1l

ZGljYWwgYW5kIFBvcHVsYXRpb24gR2VuZXRpY3MsIEJyb2FkIEluc3RpdHV0ZSBvZiBNSVQgYW5k

IEhhcnZhcmQsIENhbWJyaWRnZSwgTUEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgU3VyZ2VyeSwg

TWFzc2FjaHVzZXR0cyBHZW5lcmFsIEhvc3BpdGFsLCBCb3N0b24sIE1BLCBVU0EuJiN4RDtWQSBJ

bmZvcm1hdGljcyBhbmQgQ29tcHV0aW5nIEluZnJhc3RydWN0dXJlLCBEZXBhcnRtZW50IG9mIFZl

dGVyYW5zIEFmZmFpcnMsIFNhbHQgTGFrZSBDaXR5IEhlYWx0aCBDYXJlIFN5c3RlbSwgU2FsdCBM

YWtlIENpdHksIENULCBVU0EuJiN4RDtVbml2ZXJzaXR5IG9mIE1hc3NhY2h1c2V0dHMgQ29sbGVn

ZSBvZiBOdXJzaW5nICZhbXA7IEhlYWx0aCBTY2llbmNlcywgQm9zdG9uLCBNQSwgVVNBLiYjeEQ7

Q2VudGVyIGZvciBIZWFsdGhjYXJlIE9yZ2FuaXphdGlvbiBhbmQgSW1wbGVtZW50YXRpb24gUmVz

ZWFyY2gsIEVkaXRoIE5vdXJzZSBSb2dlcnMgTWVtb3JpYWwgVkEgSG9zcGl0YWwsIEJlZGZvcmQs

IE1BLCBVU0EuJiN4RDtWQSBQYWxvIEFsdG8gSGVhbHRoIENhcmUgU3lzdGVtLCBQYWxvIEFsdG8s

IENBLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBTdGFuZm9yZCBVbml2ZXJzaXR5

IFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQsIENBLCBVU0EuJiN4RDtNYXNzYWNodXNldHRz

IFZldGVyYW5zIEVwaWRlbWlvbG9neSBSZXNlYXJjaCBhbmQgSW5mb3JtYXRpb24gQ2VudGVyLCBW

QSBCb3N0b24gSGVhbHRoY2FyZSBTeXN0ZW0sIEJvc3RvbiwgTUEsIFVTQS4mI3hEO0RlcGFydG1l

bnQgb2YgSGVhbHRoIExhdywgUG9saWN5ICZhbXA7IE1hbmFnZW1lbnQsIEJvc3RvbiBVbml2ZXJz

aXR5IFNjaG9vbCBvZiBQdWJsaWMgSGVhbHRoLCBCb3N0b24sIE1BLCBVU0EuJiN4RDtDYXJkaW92

YXNjdWxhciBSZXNlYXJjaCBDZW50ZXIsIE1hc3NhY2h1c2V0dHMgR2VuZXJhbCBIb3NwaXRhbCwg

Qm9zdG9uLCBNQSwgVVNBLiYjeEQ7RGVwYXJ0bWVudCBvZiBTdXJnZXJ5LCBTdGFuZm9yZCBVbml2

ZXJzaXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQsIENBLCBVU0EuJiN4RDtDb3Jwb3Jh

bCBNaWNoYWVsIEouIENyZXNjZW56IFZBIE1lZGljYWwgQ2VudGVyLCBQaGlsYWRlbHBoaWEsIFBB

LCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBZYWxlIFVuaXZlcnNpdHkgU2Nob29s

IG9mIE1lZGljaW5lLCBOZXcgSGF2ZW4sIENULCBVU0EuJiN4RDtBdGxhbnRhIFZBIEhlYWx0aCBD

YXJlIFN5c3RlbSwgRGVjYXR1ciwgR0EsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgRXBpZGVtaW9s

b2d5LCBFbW9yeSBVbml2ZXJzaXR5IFJvbGxpbnMgU2Nob29sIG9mIFB1YmxpYyBIZWFsdGgsIEVt

b3J5IFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBBdGxhbnRhLCBHQSwgVVNBLiYjeEQ7

RGVwYXJ0bWVudCBvZiBCaW9tZWRpY2FsIEluZm9ybWF0aWNzLCBFbW9yeSBVbml2ZXJzaXR5IFNj

aG9vbCBvZiBNZWRpY2luZSwgQXRsYW50YSwgR0EsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgQmlv

c3RhdGlzdGljcywgRXBpZGVtaW9sb2d5LCBhbmQgSW5mb3JtYXRpY3MsIFBlcmVsbWFuIFNjaG9v

bCBvZiBNZWRpY2luZSwgUGhpbGFkZWxwaGlhLCBQQSwgVVNBLiYjeEQ7VkEgVGVubmVzc2VlIFZh

bGxleSBIZWFsdGhjYXJlIFN5c3RlbSwgTmFzaHZpbGxlLCBUTiwgVVNBLiYjeEQ7VmFuZGVyYmls

dCBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBOYXNodmlsbGUsIFROLCBVU0EuJiN4RDtDZW50

ZXIgZm9yIEhlYWx0aGNhcmUgT3JnYW5pemF0aW9uIGFuZCBJbXBsZW1lbnRhdGlvbiBSZXNlYXJj

aCwgRWRpdGggTm91cnNlIFJvZ2VycyBNZW1vcmlhbCBWZXRlcmFucyBIb3NwaXRhbCwgQmVkZm9y

ZCwgTUEsIFVTQS4mI3hEO0Jvc3RvbiBVbml2ZXJzaXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgQm9z

dG9uLCBNQSwgVVNBLiYjeEQ7UGhvZW5peCBWZXRlcmFucyBBZmZhaXJzIEhlYWx0aCBDYXJlIFN5

c3RlbSwgUGhvZW5peCwgQVosIFVTQS4mI3hEO0RpdmlzaW9uIG9mIEVwaWRlbWlvbG9neSwgRGVw

YXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBVdGFoIFNjaG9vbCBv

ZiBNZWRpY2luZSwgU2FsdCBMYWtlIENpdHksIFVULCBVU0EuJiN4RDtDYXJkaW92YXNjdWxhciBE

aXZpc2lvbiwgVmFuZGVyYmlsdCBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBOYXNodmlsbGUs

IFROLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZh

cG9zO3MgSG9zcGl0YWwsIEhhcnZhcmQgTWVkaWNhbCBTY2hvb2wsIEJvc3RvbiwgTUEsIFVTQS4m

I3hEO0NsaW5pY2FsIEVwaWRlbWlvbG9neSBSZXNlYXJjaCBDZW50ZXIsIFZBIENvbm5lY3RpY3V0

IEhlYWx0aGNhcmUgU3lzdGVtLCBXZXN0IEhhdmVuLCBDVCwgVVNBLiYjeEQ7Q2VudGVyIGZvciBE

cnVnIEV2YWx1YXRpb24gYW5kIFJlc2VhcmNoLCBVUyBGb29kIGFuZCBEcnVnIEFkbWluaXN0cmF0

aW9uLCBTaWx2ZXIgU3ByaW5nLCBNRCwgVVNBLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwg

UGVybG1hbiBTY2hvb2wgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgb2YgUGVubnN5bHZhbmlhLCBQ

aGlsYWRlbHBoaWEsIFBBLCBVU0EuJiN4RDtFbW9yeSBDbGluaWNhbCBDYXJkaW92YXNjdWxhciBS

ZXNlYXJjaCBJbnN0aXR1dGUsIEF0bGFudGEsIEdBLCBVU0EuJiN4RDtDYXJkaW92YXNjdWxhciBN

ZWRpY2luZSBEaXZpc2lvbiwgRGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgQnJpZ2hhbSBhbmQgV29t

ZW4mYXBvcztzIEhvc3BpdGFsLCBIYXJ2YXJkIE1lZGljYWwgU2Nob29sLCBCb3N0b24sIE1BLCBV

U0EuJiN4RDtDb3Jwb3JhbCBNaWNoYWVsIEouIENyZXNjZW56IFZBIE1lZGljYWwgQ2VudGVyLCBQ

aGlsYWRlbHBoaWEsIFBBLCBVU0EuIGRhbXJhdWVyQHVwZW5uLmVkdS4mI3hEO0RlcGFydG1lbnQg

b2YgU3VyZ2VyeSwgUGVybG1hbiBTY2hvb2wgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgb2YgUGVu

bnN5bHZhbmlhLCBQaGlsYWRlbHBoaWEsIFBBLCBVU0EuIGRhbXJhdWVyQHVwZW5uLmVkdS48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HZW5vbWUtd2lkZSBhc3NvY2lhdGlvbiBzdHVkeSBv

ZiBwZXJpcGhlcmFsIGFydGVyeSBkaXNlYXNlIGluIHRoZSBNaWxsaW9uIFZldGVyYW4gUHJvZ3Jh

bTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OYXQgTWVkPC9zZWNvbmRhcnktdGl0bGU+PC90aXRs

ZXM+PHBhZ2VzPjEyNzQtMTI3OTwvcGFnZXM+PHZvbHVtZT4yNTwvdm9sdW1lPjxudW1iZXI+ODwv

bnVtYmVyPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnPC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU0Ni0xNzBYIChFbGVjdHJvbmljKSYjeEQ7MTA3

OC04OTU2IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMTI4NTYzMjwvYWNjZXNzaW9u

LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMzEyODU2MzI8L3VybD48dXJsPmh0dHBzOi8vd3d3Lm5hdHVyZS5jb20vYXJ0aWNs

ZXMvczQxNTkxLTAxOS0wNDkyLTUucGRmPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj

dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDM4L3M0MTU5MS0wMTktMDQ5Mi01PC9lbGVjdHJvbmlj

LXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA 5 The results were replicated in an independent sample of 5,117 PAD cases and 389,291 controls from the UK Biobank. They identified 19 LEAD loci, 18 of which have not been previously reported. Eleven of the 19 loci were associated with disease in three vascular beds (coronary, cerebral, lower extremity), including LDLR, LPL, and Lp(a). Four of the variants appeared to be specific for LEAD, including F5 p.R506Q (Factor V Leiden variant), highlighting the pathogenic role of thrombosis in the lower extremity vascular bed and providing genetic support for Factor Xa inhibition as a therapeutic strategy for LEAD. Despite the fact that numerous long non-coding RNAs (lncRNA) have been identified, only a few of them have been studied with respect to endothelial cell homeostasis or vascular disease development. One of them, the pro-angiogenic lncRNA MANTIS (named after the carnivorous insect based on its secondary structure), may be clinically relevant in carotid disease.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWlzZWdhbmc8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFy

PjxSZWNOdW0+NDA3MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3Jp

cHQiPjY8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDczPC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNl

czJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkwNjE4MTMiPjQwNzM8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxlaXNlZ2FuZywgTS4gUy48L2F1dGhv

cj48YXV0aG9yPkJpYmxpLCBTLiBJLjwvYXV0aG9yPjxhdXRob3I+R3VudGhlciwgUy48L2F1dGhv

cj48YXV0aG9yPlBmbHVnZXItTXVsbGVyLCBCLjwvYXV0aG9yPjxhdXRob3I+T28sIEouIEEuPC9h

dXRob3I+PGF1dGhvcj5Ib3BlciwgQy48L2F1dGhvcj48YXV0aG9yPlNlcmVkaW5za2ksIFMuPC9h

dXRob3I+PGF1dGhvcj5ZZWtlbGNoeWssIE0uPC9hdXRob3I+PGF1dGhvcj5TY2htaXR6LVJpeGVu

LCBULjwvYXV0aG9yPjxhdXRob3I+U2NodXJtYW5uLCBDLjwvYXV0aG9yPjxhdXRob3I+SHUsIEou

PC9hdXRob3I+PGF1dGhvcj5Mb29zbywgTS48L2F1dGhvcj48YXV0aG9yPlNpZ2FsYSwgRi48L2F1

dGhvcj48YXV0aG9yPkJvb24sIFIuIEEuPC9hdXRob3I+PGF1dGhvcj5GbGVtaW5nLCBJLjwvYXV0

aG9yPjxhdXRob3I+QnJhbmRlcywgUi4gUC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5JbnN0aXR1dGUgZm9yIENhcmRpb3Zhc2N1bGFyIFBoeXNpb2xvZ3ks

IEdvZXRoZSBVbml2ZXJzaXR5LCBUaGVvZG9yLVN0ZXJuLUthaSA3LCBGcmFua2Z1cnQsIEdlcm1h

bnkuJiN4RDtHZXJtYW4gQ2VudGVyIG9mIENhcmRpb3Zhc2N1bGFyIFJlc2VhcmNoIChEWkhLKSwg

UGFydG5lciBTaXRlIFJoZWluTWFpbiwgVGhlb2RvciBTdGVybi1LYWkgNywgRnJhbmtmdXJ0LCBH

ZXJtYW55LiYjeEQ7SW5zdGl0dXRlIGZvciBWYXNjdWxhciBTaWduYWxsaW5nLCBHb2V0aGUgVW5p

dmVyc2l0eSwgVGhlb2RvciBTdGVybi1LYWkgNywgRnJhbmtmdXJ0LCBHZXJtYW55LiYjeEQ7TWF4

LVBsYW5jay1JbnN0aXR1dGUgZm9yIEhlYXJ0IGFuZCBMdW5nIFJlc2VhcmNoLCBFQ0NQUyBCaW9p

bmZvcm1hdGljcyBhbmQgU2VxdWVuY2luZyBGYWNpbGl0eSwgTHVkd2lnc3RyLiA0MywgQmFkIE5h

dWhlaW0sIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIFZhc2N1bGFyIGFuZCBFbmRvdmFzY3Vs

YXIgU3VyZ2VyeSwgR29ldGhlIFVuaXZlcnNpdHksIFRoZW9kb3ItU3Rlcm4tS2FpIDcsIEZyYW5r

ZnVydCwgR2VybWFueS4mI3hEOzFzdCBEZXBhcnRtZW50IG9mIFByb3BhZWRldXRpYyBTdXJnZXJ5

LCBVbml2ZXJzaXR5IG9mIEF0aGVucyBNZWRpY2FsIFNjaG9vbCwgSGlwcG9jcmF0aW9uIEhvc3Bp

dGFsLCBFdGhlcm9zIDctOSwgQXRoZW5zLCBHcmVlY2UuJiN4RDtJbnN0aXR1dGUgb2YgQ2FyZGlv

dmFzY3VsYXIgUmVnZW5lcmF0aW9uLCBHb2V0aGUgVW5pdmVyc2l0eSwgRnJhbmtmdXJ0LCBUaGVv

ZG9yLVN0ZXJuLUthaSA3LCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBQaHlzaW9sb2d5LCBW

VSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBEZSBCb2VsZWxhYW4gMTExOCwgSFYgQW1zdGVy

ZGFtLCB0aGUgTmV0aGVybGFuZHMuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UGxlaW90

cm9waWMgZWZmZWN0cyBvZiBsYW1pbmFyIGZsb3cgYW5kIHN0YXRpbnMgZGVwZW5kIG9uIHRoZSBL

cnVwcGVsLWxpa2UgZmFjdG9yLWluZHVjZWQgbG5jUk5BIE1BTlRJUzwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwYWdlcz4yNTIz

LTI1MzM8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48bnVtYmVyPjMwPC9udW1iZXI+PGtleXdv

cmRzPjxrZXl3b3JkPkF0aGVyb3NjbGVyb3Npczwva2V5d29yZD48a2V5d29yZD5JY2FtLTE8L2tl

eXdvcmQ+PGtleXdvcmQ+TGFtaW5hciBmbG93PC9rZXl3b3JkPjxrZXl3b3JkPlN0YXRpbjwva2V5

d29yZD48a2V5d29yZD5sbmNSTkE8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAx

OTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZyA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNi

bj48YWNjZXNzaW9uLW51bT4zMTIyMjIyMTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzEyMjIyMjE8L3Vy

bD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9laHozOTMucGRmP3Rva2Vu

PUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3

Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJBRENDQW1JR0NTcUdTSWIzRFFFSEFUQWVC

Z2xnaGtnQlpRTUVBUzR3RVFRTTl5UTROaWpmcjZRSDVreVZBZ0VRZ0lJQ015V0ZIcUZoMzNzSHBZ

T2lVY3h2MjlIQXFEcWxpMHRfRjFLajhhb0R2ZlUtQTFhbktiRzhEYUwyRi1fdXlJaFFocVJUX0No

SGJhbVRFTU1jYUJXcl90bTJTc0l2TC1ndzhrQmUtYlduVXNMamxaZm5UZlJSaGtQS2hRcGpicGVn

RHRvTHZBbEdTY2JJTE14SVlocmF5UjZ0N0dJcFIyNEt4SHNZTkNSMng0eE96X25fT1BoXzY1LXE1

R01odHJ4cHkxVnp5aEV6RHhIekZNenF4MERXMVZ3VzY2NnBhRzdQM1JIYUtJRmxGa1hKVG1Ia0ND

NTZ1RF9jX2ljUjhxd1c5VC11eUo1SkFWZnUwVnZYZ3F6WVZRQ1A2MzlXXzh5SUdHUjRSb3dlRU1h

LUQzQmRpVm9mWVJvS2lTVERpT1VqdC1wc1VIY3NadkdiLTVJTHVOS3Y0NWt1NTQ4WHp6NTY1XzFO

NVlFN3FjTTVxcDNzNS02N2RnaTNNSTBrM1BXcF93Sm5VbHQyaTQwYUhReTVZa2Y3cjdCUllVOHhp

aUh0TUp0a1p2TXBmVzZSc0JSdzhXajkzX2VOQ0ZuSmN4UTZRUThoWTNXdlFsc3dGSnQtNjlBNWNs

Z19mYldlWkppcFN2aFhvS1lNQlRkQ1haN21Va3dhb3J2RFQzaG9vdFBzWng3Q2NpOTIzRFVYcnk0

SjNNWGFqMzdEQUU1ZWh2NFBTUkJ2OUtqSl8wX0ZZbDEydWRxOG43VXZoS0RucG5LeXlKX1pPMWhX

REFPZGJaaHlJUk10eG93UE5oODkyMnRfd2hEVVE3TzQxV1R5aTRnMEZPWDBpY21rWFdwbFVVdmRU

aXJrX3BpcFMyVFNtbW9PS0ZFRzhnSXkzel95VmN1ckdzbWZtbFNPb2NSMGNwMV85dVdqTzQzT1ZJ

WnBnZVdVYzhUbXd0SnhtQXAxYWlObmNxbVY3QXRPSnRqYzd5dlc4bHNpOVhEd240Q29oYkdIPC91

cmw+PHVybD5odHRwczovL2FjYWRlbWljLm91cC5jb20vZXVyaGVhcnRqL2FydGljbGUvNDAvMzAv

MjUyMy81NTIxMzYyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291

cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHozOTM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWlzZWdhbmc8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFy

PjxSZWNOdW0+NDA3MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3Jp

cHQiPjY8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDczPC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNl

czJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkwNjE4MTMiPjQwNzM8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxlaXNlZ2FuZywgTS4gUy48L2F1dGhv

cj48YXV0aG9yPkJpYmxpLCBTLiBJLjwvYXV0aG9yPjxhdXRob3I+R3VudGhlciwgUy48L2F1dGhv

cj48YXV0aG9yPlBmbHVnZXItTXVsbGVyLCBCLjwvYXV0aG9yPjxhdXRob3I+T28sIEouIEEuPC9h

dXRob3I+PGF1dGhvcj5Ib3BlciwgQy48L2F1dGhvcj48YXV0aG9yPlNlcmVkaW5za2ksIFMuPC9h

dXRob3I+PGF1dGhvcj5ZZWtlbGNoeWssIE0uPC9hdXRob3I+PGF1dGhvcj5TY2htaXR6LVJpeGVu

LCBULjwvYXV0aG9yPjxhdXRob3I+U2NodXJtYW5uLCBDLjwvYXV0aG9yPjxhdXRob3I+SHUsIEou

PC9hdXRob3I+PGF1dGhvcj5Mb29zbywgTS48L2F1dGhvcj48YXV0aG9yPlNpZ2FsYSwgRi48L2F1

dGhvcj48YXV0aG9yPkJvb24sIFIuIEEuPC9hdXRob3I+PGF1dGhvcj5GbGVtaW5nLCBJLjwvYXV0

aG9yPjxhdXRob3I+QnJhbmRlcywgUi4gUC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5JbnN0aXR1dGUgZm9yIENhcmRpb3Zhc2N1bGFyIFBoeXNpb2xvZ3ks

IEdvZXRoZSBVbml2ZXJzaXR5LCBUaGVvZG9yLVN0ZXJuLUthaSA3LCBGcmFua2Z1cnQsIEdlcm1h

bnkuJiN4RDtHZXJtYW4gQ2VudGVyIG9mIENhcmRpb3Zhc2N1bGFyIFJlc2VhcmNoIChEWkhLKSwg

UGFydG5lciBTaXRlIFJoZWluTWFpbiwgVGhlb2RvciBTdGVybi1LYWkgNywgRnJhbmtmdXJ0LCBH

ZXJtYW55LiYjeEQ7SW5zdGl0dXRlIGZvciBWYXNjdWxhciBTaWduYWxsaW5nLCBHb2V0aGUgVW5p

dmVyc2l0eSwgVGhlb2RvciBTdGVybi1LYWkgNywgRnJhbmtmdXJ0LCBHZXJtYW55LiYjeEQ7TWF4

LVBsYW5jay1JbnN0aXR1dGUgZm9yIEhlYXJ0IGFuZCBMdW5nIFJlc2VhcmNoLCBFQ0NQUyBCaW9p

bmZvcm1hdGljcyBhbmQgU2VxdWVuY2luZyBGYWNpbGl0eSwgTHVkd2lnc3RyLiA0MywgQmFkIE5h

dWhlaW0sIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIFZhc2N1bGFyIGFuZCBFbmRvdmFzY3Vs

YXIgU3VyZ2VyeSwgR29ldGhlIFVuaXZlcnNpdHksIFRoZW9kb3ItU3Rlcm4tS2FpIDcsIEZyYW5r

ZnVydCwgR2VybWFueS4mI3hEOzFzdCBEZXBhcnRtZW50IG9mIFByb3BhZWRldXRpYyBTdXJnZXJ5

LCBVbml2ZXJzaXR5IG9mIEF0aGVucyBNZWRpY2FsIFNjaG9vbCwgSGlwcG9jcmF0aW9uIEhvc3Bp

dGFsLCBFdGhlcm9zIDctOSwgQXRoZW5zLCBHcmVlY2UuJiN4RDtJbnN0aXR1dGUgb2YgQ2FyZGlv

dmFzY3VsYXIgUmVnZW5lcmF0aW9uLCBHb2V0aGUgVW5pdmVyc2l0eSwgRnJhbmtmdXJ0LCBUaGVv

ZG9yLVN0ZXJuLUthaSA3LCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBQaHlzaW9sb2d5LCBW

VSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBEZSBCb2VsZWxhYW4gMTExOCwgSFYgQW1zdGVy

ZGFtLCB0aGUgTmV0aGVybGFuZHMuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UGxlaW90

cm9waWMgZWZmZWN0cyBvZiBsYW1pbmFyIGZsb3cgYW5kIHN0YXRpbnMgZGVwZW5kIG9uIHRoZSBL

cnVwcGVsLWxpa2UgZmFjdG9yLWluZHVjZWQgbG5jUk5BIE1BTlRJUzwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwYWdlcz4yNTIz

LTI1MzM8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48bnVtYmVyPjMwPC9udW1iZXI+PGtleXdv

cmRzPjxrZXl3b3JkPkF0aGVyb3NjbGVyb3Npczwva2V5d29yZD48a2V5d29yZD5JY2FtLTE8L2tl

eXdvcmQ+PGtleXdvcmQ+TGFtaW5hciBmbG93PC9rZXl3b3JkPjxrZXl3b3JkPlN0YXRpbjwva2V5

d29yZD48a2V5d29yZD5sbmNSTkE8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAx

OTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZyA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNi

bj48YWNjZXNzaW9uLW51bT4zMTIyMjIyMTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzEyMjIyMjE8L3Vy

bD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9laHozOTMucGRmP3Rva2Vu

PUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3

Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJBRENDQW1JR0NTcUdTSWIzRFFFSEFUQWVC

Z2xnaGtnQlpRTUVBUzR3RVFRTTl5UTROaWpmcjZRSDVreVZBZ0VRZ0lJQ015V0ZIcUZoMzNzSHBZ

T2lVY3h2MjlIQXFEcWxpMHRfRjFLajhhb0R2ZlUtQTFhbktiRzhEYUwyRi1fdXlJaFFocVJUX0No

SGJhbVRFTU1jYUJXcl90bTJTc0l2TC1ndzhrQmUtYlduVXNMamxaZm5UZlJSaGtQS2hRcGpicGVn

RHRvTHZBbEdTY2JJTE14SVlocmF5UjZ0N0dJcFIyNEt4SHNZTkNSMng0eE96X25fT1BoXzY1LXE1

R01odHJ4cHkxVnp5aEV6RHhIekZNenF4MERXMVZ3VzY2NnBhRzdQM1JIYUtJRmxGa1hKVG1Ia0ND

NTZ1RF9jX2ljUjhxd1c5VC11eUo1SkFWZnUwVnZYZ3F6WVZRQ1A2MzlXXzh5SUdHUjRSb3dlRU1h

LUQzQmRpVm9mWVJvS2lTVERpT1VqdC1wc1VIY3NadkdiLTVJTHVOS3Y0NWt1NTQ4WHp6NTY1XzFO

NVlFN3FjTTVxcDNzNS02N2RnaTNNSTBrM1BXcF93Sm5VbHQyaTQwYUhReTVZa2Y3cjdCUllVOHhp

aUh0TUp0a1p2TXBmVzZSc0JSdzhXajkzX2VOQ0ZuSmN4UTZRUThoWTNXdlFsc3dGSnQtNjlBNWNs

Z19mYldlWkppcFN2aFhvS1lNQlRkQ1haN21Va3dhb3J2RFQzaG9vdFBzWng3Q2NpOTIzRFVYcnk0

SjNNWGFqMzdEQUU1ZWh2NFBTUkJ2OUtqSl8wX0ZZbDEydWRxOG43VXZoS0RucG5LeXlKX1pPMWhX

REFPZGJaaHlJUk10eG93UE5oODkyMnRfd2hEVVE3TzQxV1R5aTRnMEZPWDBpY21rWFdwbFVVdmRU

aXJrX3BpcFMyVFNtbW9PS0ZFRzhnSXkzel95VmN1ckdzbWZtbFNPb2NSMGNwMV85dVdqTzQzT1ZJ

WnBnZVdVYzhUbXd0SnhtQXAxYWlObmNxbVY3QXRPSnRqYzd5dlc4bHNpOVhEd240Q29oYkdIPC91

cmw+PHVybD5odHRwczovL2FjYWRlbWljLm91cC5jb20vZXVyaGVhcnRqL2FydGljbGUvNDAvMzAv

MjUyMy81NTIxMzYyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291

cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHozOTM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA 6 In fact, the protective effects of laminar flow and statins are, at least in part, attributed to the expression of MANTIS. The mechanisms involve epigenetic rearrangements and the transcription factors Krüppel-like factor 2 and 4. As induction of MANTIS mimics the beneficial effects of statins on endothelial function, the authors proposed that strategies to increase MANTIS might improve vascular function in patients not responding to statin therapy. The transcriptional activity of nuclear receptors that regulate key pathophysiological processes in atherosclerosis development is controlled by the nuclear receptor corepressors (NCOR), scaffolding proteins that form the basis of large corepressor complexes. Oppi et al investigated the role of NCOR1 in atherogenesis.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PcHBpPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQwODY8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij43

PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA4NjwvcmVjLW51bWJl

cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMycjc1

MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5NTk0NjY1Ij40MDg2PC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5PcHBpLCBTLjwvYXV0aG9yPjxhdXRob3I+TnVz

c2VyLVN0ZWluLCBTLjwvYXV0aG9yPjxhdXRob3I+Qmx5c3pjenVrLCBQLjwvYXV0aG9yPjxhdXRo

b3I+V2FuZywgWC48L2F1dGhvcj48YXV0aG9yPkpvbWFyZCwgQS48L2F1dGhvcj48YXV0aG9yPk1h

cnpvbGxhLCBWLjwvYXV0aG9yPjxhdXRob3I+WWFuZywgSy48L2F1dGhvcj48YXV0aG9yPlZlbGFn

YXB1ZGksIFMuPC9hdXRob3I+PGF1dGhvcj5XYXJkLCBMLiBKLjwvYXV0aG9yPjxhdXRob3I+WXVh

biwgWC4gTS48L2F1dGhvcj48YXV0aG9yPkdlaWdlciwgTS4gQS48L2F1dGhvcj48YXV0aG9yPkd1

aWxsYXVtb24sIEEuIFQuPC9hdXRob3I+PGF1dGhvcj5PdGhtYW4sIEEuPC9hdXRob3I+PGF1dGhv

cj5Ib3JuZW1hbm4sIFQuPC9hdXRob3I+PGF1dGhvcj5SYW5jaWMsIFouPC9hdXRob3I+PGF1dGhv

cj5SeXUsIEQuPC9hdXRob3I+PGF1dGhvcj5Pb3N0ZXJ2ZWVyLCBNLiBILjwvYXV0aG9yPjxhdXRo

b3I+T3N0bywgRS48L2F1dGhvcj48YXV0aG9yPkx1c2NoZXIsIFQuIEYuPC9hdXRob3I+PGF1dGhv

cj5TdGVpbiwgUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5DZW50ZXIgZm9yIE1vbGVjdWxhciBDYXJkaW9sb2d5LCBVbml2ZXJzaXR5IG9mIFp1cmljaCwg

V2FnaXN0cmFzc2UgMTIsIFNjaGxpZXJlbiwgU3dpdHplcmxhbmQuJiN4RDtEZXBhcnRtZW50IG9m

IFJoZXVtYXRvbG9neSwgQ2VudGVyIG9mIEV4cGVyaW1lbnRhbCBSaGV1bWF0b2xvZ3ksIFVuaXZl

cnNpdHkgSG9zcGl0YWwgWnVyaWNoLCBadXJpY2gsIFN3aXR6ZXJsYW5kLiYjeEQ7RGVwYXJ0bWVu

dCBvZiBDbGluaWNhbCBJbW11bm9sb2d5LCBKYWdpZWxsb25pYW4gVW5pdmVyc2l0eSBNZWRpY2Fs

IENvbGxlZ2UsIENyYWNvdywgUG9sYW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBQbGFudCBTY2llbmNl

LCBTY2hvb2wgb2YgQWdyaWN1bHR1cmUgYW5kIEJpb2xvZ3ksIFNoYW5naGFpIEppYW8gVG9uZyBV

bml2ZXJzaXR5LCBTaGFuZ2hhaSwgQ2hpbmEuJiN4RDtMYWJvcmF0b3J5IG9mIFRyYW5zbGF0aW9u

YWwgTnV0cml0aW9uIEJpb2xvZ3ksIEluc3RpdHV0ZSBvZiBGb29kLCBOdXRyaXRpb24gYW5kIEhl

YWx0aCwgRVRIIFp1cmljaCwgU2Nod2VyemVuYmFjaCwgU3dpdHplcmxhbmQuJiN4RDtJbnN0aXR1

dGUgZm9yIENsaW5pY2FsIENoZW1pc3RyeSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBadXJpY2gsIFp1

cmljaCwgU3dpdHplcmxhbmQuJiN4RDtMYWJvcmF0b3J5IG9mIENhcmRpb3Zhc2N1bGFyIEVuZG9j

cmlub2xvZ3ksIElSQ0NTIFNhbiBSYWZmYWVsZSBQaXNhbmEsIFJvbWUsIEl0YWx5LiYjeEQ7RGVw

YXJ0bWVudCBvZiBDbGluaWNhbCBhbmQgRXhwZXJpbWVudGFsIE1lZGljaW5lLCBMaW5rb3Bpbmcg

VW5pdmVyc2l0eSwgTGlua29waW5nLCBTd2VkZW4uJiN4RDtWYXNjdWxhciBEaXNlYXNlcyBEaXNj

aXBsaW5lLCBDbGluaWNzIEhvc3BpdGFsIG9mIHRoZSBVbml2ZXJzaXR5IG9mIENhbXBpbmFzLCBD

YW1waW5hcywgQnJhemlsLiYjeEQ7Q2xpbmljIGZvciBWYXNjdWxhciBTdXJnZXJ5LCBVbml2ZXJz

aXR5IEhvc3BpdGFsIFp1cmljaCwgWnVyaWNoLCBTd2l0emVybGFuZC4mI3hEO0RlcGFydG1lbnQg

b2YgTW9sZWN1bGFyIENlbGwgQmlvbG9neSwgU3VuZ2t5dW5rd2FuIFVuaXZlcnNpdHkgU2Nob29s

IG9mIE1lZGljaW5lLCBTdXdvbiwgUmVwdWJsaWMgb2YgS29yZWEuJiN4RDtEZXBhcnRtZW50IG9m

IFBlZGlhdHJpY3MsIENlbnRlciBmb3IgTGl2ZXIgRGlnZXN0aXZlIGFuZCBNZXRhYm9saWMgRGlz

ZWFzZXMsIFVuaXZlcnNpdHkgb2YgR3JvbmluZ2VuLCBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVy

IEdyb25pbmdlbiwgR3JvbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtEZXBhcnRtZW50IG9m

IENhcmRpb2xvZ3ksIFJveWFsIEJyb21wdG9uICZhbXA7IEhhcmVmaWVsZCBIb3NwaXRhbCBUcnVz

dCwgTG9uZG9uLCBVSy4mI3hEO0ltcGVyaWFsIENvbGxlZ2UgTG9uZG9uLCBMb25kb24sIFVLLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk1hY3JvcGhhZ2UgTkNPUjEgcHJvdGVjdHMgZnJv

bSBhdGhlcm9zY2xlcm9zaXMgYnkgcmVwcmVzc2luZyBhIHByby1hdGhlcm9nZW5pYyBQUEFSZ2Ft

bWEgc2lnbmF0dXJlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBIZWFydCBKPC9zZWNvbmRh

cnktdGl0bGU+PC90aXRsZXM+PGtleXdvcmRzPjxrZXl3b3JkPkF0aGVyb3NjbGVyb3Npczwva2V5

d29yZD48a2V5d29yZD5JbW11bm9tZXRhYm9saWMgZGlzZWFzZTwva2V5d29yZD48a2V5d29yZD5N

ZWNoYW5pc20gb2YgZGlzZWFzZTwva2V5d29yZD48a2V5d29yZD5OY29yMTwva2V5d29yZD48a2V5

d29yZD5OdWNsZWFyIHJlY2VwdG9yIGNvcmVwcmVzc29yPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXAgMTY8L2RhdGU+PC9wdWIt

ZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFgg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMxNTI5MDIwPC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1l

ZC8zMTUyOTAyMDwvdXJsPjx1cmw+aHR0cHM6Ly9hY2FkZW1pYy5vdXAuY29tL2V1cmhlYXJ0ai9h

ZHZhbmNlLWFydGljbGUtYWJzdHJhY3QvZG9pLzEwLjEwOTMvZXVyaGVhcnRqL2VoejY2Ny81NTcw

MDEwP3JlZGlyZWN0ZWRGcm9tPWZ1bGx0ZXh0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHo2Njc8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PcHBpPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQwODY8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij43

PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA4NjwvcmVjLW51bWJl

cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMycjc1

MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5NTk0NjY1Ij40MDg2PC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5PcHBpLCBTLjwvYXV0aG9yPjxhdXRob3I+TnVz

c2VyLVN0ZWluLCBTLjwvYXV0aG9yPjxhdXRob3I+Qmx5c3pjenVrLCBQLjwvYXV0aG9yPjxhdXRo

b3I+V2FuZywgWC48L2F1dGhvcj48YXV0aG9yPkpvbWFyZCwgQS48L2F1dGhvcj48YXV0aG9yPk1h

cnpvbGxhLCBWLjwvYXV0aG9yPjxhdXRob3I+WWFuZywgSy48L2F1dGhvcj48YXV0aG9yPlZlbGFn

YXB1ZGksIFMuPC9hdXRob3I+PGF1dGhvcj5XYXJkLCBMLiBKLjwvYXV0aG9yPjxhdXRob3I+WXVh

biwgWC4gTS48L2F1dGhvcj48YXV0aG9yPkdlaWdlciwgTS4gQS48L2F1dGhvcj48YXV0aG9yPkd1

aWxsYXVtb24sIEEuIFQuPC9hdXRob3I+PGF1dGhvcj5PdGhtYW4sIEEuPC9hdXRob3I+PGF1dGhv

cj5Ib3JuZW1hbm4sIFQuPC9hdXRob3I+PGF1dGhvcj5SYW5jaWMsIFouPC9hdXRob3I+PGF1dGhv

cj5SeXUsIEQuPC9hdXRob3I+PGF1dGhvcj5Pb3N0ZXJ2ZWVyLCBNLiBILjwvYXV0aG9yPjxhdXRo

b3I+T3N0bywgRS48L2F1dGhvcj48YXV0aG9yPkx1c2NoZXIsIFQuIEYuPC9hdXRob3I+PGF1dGhv

cj5TdGVpbiwgUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5DZW50ZXIgZm9yIE1vbGVjdWxhciBDYXJkaW9sb2d5LCBVbml2ZXJzaXR5IG9mIFp1cmljaCwg

V2FnaXN0cmFzc2UgMTIsIFNjaGxpZXJlbiwgU3dpdHplcmxhbmQuJiN4RDtEZXBhcnRtZW50IG9m

IFJoZXVtYXRvbG9neSwgQ2VudGVyIG9mIEV4cGVyaW1lbnRhbCBSaGV1bWF0b2xvZ3ksIFVuaXZl

cnNpdHkgSG9zcGl0YWwgWnVyaWNoLCBadXJpY2gsIFN3aXR6ZXJsYW5kLiYjeEQ7RGVwYXJ0bWVu

dCBvZiBDbGluaWNhbCBJbW11bm9sb2d5LCBKYWdpZWxsb25pYW4gVW5pdmVyc2l0eSBNZWRpY2Fs

IENvbGxlZ2UsIENyYWNvdywgUG9sYW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBQbGFudCBTY2llbmNl

LCBTY2hvb2wgb2YgQWdyaWN1bHR1cmUgYW5kIEJpb2xvZ3ksIFNoYW5naGFpIEppYW8gVG9uZyBV

bml2ZXJzaXR5LCBTaGFuZ2hhaSwgQ2hpbmEuJiN4RDtMYWJvcmF0b3J5IG9mIFRyYW5zbGF0aW9u

YWwgTnV0cml0aW9uIEJpb2xvZ3ksIEluc3RpdHV0ZSBvZiBGb29kLCBOdXRyaXRpb24gYW5kIEhl

YWx0aCwgRVRIIFp1cmljaCwgU2Nod2VyemVuYmFjaCwgU3dpdHplcmxhbmQuJiN4RDtJbnN0aXR1

dGUgZm9yIENsaW5pY2FsIENoZW1pc3RyeSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBadXJpY2gsIFp1

cmljaCwgU3dpdHplcmxhbmQuJiN4RDtMYWJvcmF0b3J5IG9mIENhcmRpb3Zhc2N1bGFyIEVuZG9j

cmlub2xvZ3ksIElSQ0NTIFNhbiBSYWZmYWVsZSBQaXNhbmEsIFJvbWUsIEl0YWx5LiYjeEQ7RGVw

YXJ0bWVudCBvZiBDbGluaWNhbCBhbmQgRXhwZXJpbWVudGFsIE1lZGljaW5lLCBMaW5rb3Bpbmcg

VW5pdmVyc2l0eSwgTGlua29waW5nLCBTd2VkZW4uJiN4RDtWYXNjdWxhciBEaXNlYXNlcyBEaXNj

aXBsaW5lLCBDbGluaWNzIEhvc3BpdGFsIG9mIHRoZSBVbml2ZXJzaXR5IG9mIENhbXBpbmFzLCBD

YW1waW5hcywgQnJhemlsLiYjeEQ7Q2xpbmljIGZvciBWYXNjdWxhciBTdXJnZXJ5LCBVbml2ZXJz

aXR5IEhvc3BpdGFsIFp1cmljaCwgWnVyaWNoLCBTd2l0emVybGFuZC4mI3hEO0RlcGFydG1lbnQg

b2YgTW9sZWN1bGFyIENlbGwgQmlvbG9neSwgU3VuZ2t5dW5rd2FuIFVuaXZlcnNpdHkgU2Nob29s

IG9mIE1lZGljaW5lLCBTdXdvbiwgUmVwdWJsaWMgb2YgS29yZWEuJiN4RDtEZXBhcnRtZW50IG9m

IFBlZGlhdHJpY3MsIENlbnRlciBmb3IgTGl2ZXIgRGlnZXN0aXZlIGFuZCBNZXRhYm9saWMgRGlz

ZWFzZXMsIFVuaXZlcnNpdHkgb2YgR3JvbmluZ2VuLCBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVy

IEdyb25pbmdlbiwgR3JvbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtEZXBhcnRtZW50IG9m

IENhcmRpb2xvZ3ksIFJveWFsIEJyb21wdG9uICZhbXA7IEhhcmVmaWVsZCBIb3NwaXRhbCBUcnVz

dCwgTG9uZG9uLCBVSy4mI3hEO0ltcGVyaWFsIENvbGxlZ2UgTG9uZG9uLCBMb25kb24sIFVLLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk1hY3JvcGhhZ2UgTkNPUjEgcHJvdGVjdHMgZnJv

bSBhdGhlcm9zY2xlcm9zaXMgYnkgcmVwcmVzc2luZyBhIHByby1hdGhlcm9nZW5pYyBQUEFSZ2Ft

bWEgc2lnbmF0dXJlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBIZWFydCBKPC9zZWNvbmRh

cnktdGl0bGU+PC90aXRsZXM+PGtleXdvcmRzPjxrZXl3b3JkPkF0aGVyb3NjbGVyb3Npczwva2V5

d29yZD48a2V5d29yZD5JbW11bm9tZXRhYm9saWMgZGlzZWFzZTwva2V5d29yZD48a2V5d29yZD5N

ZWNoYW5pc20gb2YgZGlzZWFzZTwva2V5d29yZD48a2V5d29yZD5OY29yMTwva2V5d29yZD48a2V5

d29yZD5OdWNsZWFyIHJlY2VwdG9yIGNvcmVwcmVzc29yPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXAgMTY8L2RhdGU+PC9wdWIt

ZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFgg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMxNTI5MDIwPC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1l

ZC8zMTUyOTAyMDwvdXJsPjx1cmw+aHR0cHM6Ly9hY2FkZW1pYy5vdXAuY29tL2V1cmhlYXJ0ai9h

ZHZhbmNlLWFydGljbGUtYWJzdHJhY3QvZG9pLzEwLjEwOTMvZXVyaGVhcnRqL2VoejY2Ny81NTcw

MDEwP3JlZGlyZWN0ZWRGcm9tPWZ1bGx0ZXh0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHo2Njc8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA 7 Myeloid cell-specific deletion of NCOR1 in LDL receptor knockout mice aggravated atherosclerosis development. Macrophage NCOR1-deficiency led to increased foam cell formation, enhanced expression of pro-inflammatory cytokines, and atherosclerotic lesions characterized by larger necrotic cores and thinner fibrous caps. The immunometabolic effects of NCOR1 were mediated via suppression of peroxisome proliferator-activated receptor gamma (PPARγ) target genes in mouse and human macrophages, which lead to an enhanced expression of the CD36 scavenger receptor and subsequent increase in oxidized LDL uptake in the absence of NCOR1. Interestingly, in human atherosclerotic plaques, the expression of NCOR1 was reduced whereas the PPARγ signature was increased, and this signature was more pronounced in ruptured compared with non-ruptured carotid plaques. The data suggest that stabilizing the NCOR1-PPARγ binding could be a promising strategy to block the pro-atherogenic functions of plaque macrophages and lesion progression in atherosclerotic patients.Radiotherapy-induced CVD is an emerging problem in a growing population of cancer survivors where traditional vascular treatments have limited benefits. Using a translational approach (Figure 1), it was now shown that human irradiated blood vessels exhibit elevated levels of inflammation signals associated with inflammasome activation long after radiotherapy, and similar changes occurred in a mouse model of localized irradiation to the heart and carotids.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaHJpc3RlcnNkb3R0aXI8L0F1dGhvcj48WWVhcj4yMDE5

PC9ZZWFyPjxSZWNOdW0+NDA3MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3Vw

ZXJzY3JpcHQiPjg8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDcy

PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZq

eHB6YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkwNjE2MDkiPjQwNzI8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNocmlzdGVyc2RvdHRpciwg

VC48L2F1dGhvcj48YXV0aG9yPlBpcmF1bHQsIEouPC9hdXRob3I+PGF1dGhvcj5HaXN0ZXJhLCBB

LjwvYXV0aG9yPjxhdXRob3I+QmVyZ21hbiwgTy48L2F1dGhvcj48YXV0aG9yPkdhbGxpbmEsIEEu

IEwuPC9hdXRob3I+PGF1dGhvcj5CYXVtZ2FydG5lciwgUi48L2F1dGhvcj48YXV0aG9yPkx1bmRi

ZXJnLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+RXJpa3Nzb24sIFAuPC9hdXRob3I+PGF1dGhvcj5Z

YW4sIFouIFEuPC9hdXRob3I+PGF1dGhvcj5QYXVsc3Nvbi1CZXJuZSwgRy48L2F1dGhvcj48YXV0

aG9yPkhhbnNzb24sIEcuIEsuPC9hdXRob3I+PGF1dGhvcj5PbG9mc3NvbiwgUC4gUy48L2F1dGhv

cj48YXV0aG9yPkhhbGxlLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgTW9sZWN1bGFyIE1lZGljaW5lIGFuZCBTdXJnZXJ5LCBL

YXJvbGluc2thIEluc3RpdHV0ZXQsIEthcm9saW5za2EgVW5pdmVyc2l0eSBIb3NwaXRhbCwgU3Rv

Y2tob2xtLCBTd2VkZW4uJiN4RDtTdC4gRXJpayBFeWUgSG9zcGl0YWwsIFN0b2NraG9sbSwgU3dl

ZGVuLiYjeEQ7Q2FyZGlvdmFzY3VsYXIgTWVkaWNpbmUgVW5pdCwgRGVwYXJ0bWVudCBvZiBNZWRp

Y2luZSwgQ2VudGVyIGZvciBNb2xlY3VsYXIgTWVkaWNpbmUsIEthcm9saW5za2EgSW5zdGl0dXRl

dCBhbmQgS2Fyb2xpbnNrYSBVbml2ZXJzaXR5IEhvc3BpdGFsLCBCaW9jbGluaWN1bSBKODoyMCwg

VmlzaW9uc2dhdGFuIDQsIFN0b2NraG9sbSwgU3dlZGVuLiYjeEQ7UmVjb25zdHJ1Y3RpdmUgUGxh

c3RpYyBTdXJnZXJ5LCBLYXJvbGluc2thIFVuaXZlcnNpdHkgSG9zcGl0YWwsIFN0b2NraG9sbSwg

U3dlZGVuLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlByZXZlbnRpb24gb2YgcmFkaW90

aGVyYXB5LWluZHVjZWQgYXJ0ZXJpYWwgaW5mbGFtbWF0aW9uIGJ5IGludGVybGV1a2luLTEgYmxv

Y2thZGU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+MjQ5NS0yNTAzPC9wYWdlcz48dm9sdW1lPjQwPC92b2x1bWU+PG51

bWJlcj4zMDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbmFraW5yYTwva2V5d29yZD48a2V5

d29yZD5DY2wyPC9rZXl3b3JkPjxrZXl3b3JkPkludGVybGV1a2luLTE8L2tleXdvcmQ+PGtleXdv

cmQ+TWNwLTE8L2tleXdvcmQ+PGtleXdvcmQ+UmFkaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlZh

c2N1bGFyIGRpc2Vhc2U8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVh

cj48cHViLWRhdGVzPjxkYXRlPkF1ZyA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNj

ZXNzaW9uLW51bT4zMTA4MTAzODwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1

cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzEwODEwMzg8L3VybD48dXJs

Pmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcG1jL2FydGljbGVzL1BNQzY2ODUzMjgvcGRm

L2VoejIwNi5wZGY8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9l

aHoyMDYucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3Fm

S0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJBRENDQW1JR0NT

cUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTVFEeDJfSjE1cFRyUnV4MEhBZ0VRZ0lJ

Q002WW5aTGhocnpuenBsay1XQjl1Zzg5QkNfaDgxUDhqSDBqaVBGZGY4ekNkZkE4d1h0aG1ZaTJF

em5aVFl2QmIxZmRQbE4xT0I3ZmR3Ui1jeXNpa19FUVA2R1Y3NUw2Z0FOT1lfamVteUYxaHM3LUdU

Y0FlVHFkOXN5aDFmbThTMkQta01SdXd6eVBJYURQUUI3dlBLQTJvYzNBWENUM2lzajE2WEh0VFpN

dUxBVUxXSGY1WkpqdkpUbXdlamVWb0VnODI5Q2o4VGhBTG5YSU5WY19MQWRrVGdKbTV1TTFKcnRI

ZDZOeks5X0hIR2VISjVld1VxMWR2LXI1d0FrcXdNQUt0LU9JRl9UejBvZWJRb2lYX1RhLThGdmF1

OXFrU1Fzcjg0dEpkTmxkUGxaM1VaZmlwQy1uOVlTUkdtU0I3RFlpbHdGV2FuQXdvSHZXUHBGWDVG

WHh0anNzX0xiVjZIWEc3UmlUcE1IT2VVdXlXZEZfSWd2eFRvd1ZVRDRMcU5DVkJSa0dZd2twSDBW

NW9wd3VIUzlLM3ZWbC1IZE1iOC1GckZnUnUwRkM1SUR3WHp2cXZwOGVOcmZTbzZZeHd1SUpqZjFz

eURlS3JlVlpOc3ZKTGgyU1V4c1ZxRFZRaDFfeG43Xzl3WHp4STdiRklmY2ZuNE1FSGV2cjdrMFhz

VVNMUzJicm1vUGljRkhVZkJ1RURiMDFseHM4NHFua2NLNjd0eTduTFhnTjh3MGJxMzNGZEVBV3JK

RnRNMTVIWVlNTm54VzV3TXhxbi1oeVBZcm54MXJzM2tHd2xWbDlCcXhFVTZDeU9TZDNJZ3QtdDBf

Mm1KRWRxYlJuTlUtQjhSWG1tSUw1UWVtUThSVXB1Y1JTdkZLS2VzQk9aWkRIT0ZtbmZEb1JxWDVN

MENNN0hjVWJzNnhydklQdGc1cXdzUWIzQV9nVTREdV9hZHBQdjhtWEhHc3pQOVoxR1lpemNqNFE1

SjVEZElZV1h0cWdpPC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3BtYy9h

cnRpY2xlcy9QTUM2Njg1MzI4LzwvdXJsPjx1cmw+aHR0cHM6Ly93YXRlcm1hcmsuc2lsdmVyY2hh

aXIuY29tL2VoejIwNi5wZGY/dG9rZW49QVFFQ0FIaTIwOEJFNDlPb2FuOWtraFdfRXJjeTdEbTNa

TF85Q2YzcWZLQWM0ODV5c2dBQUFvQXdnZ0o4QmdrcWhraUc5dzBCQndhZ2dnSnRNSUlDYVFJQkFE

Q0NBbUlHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFNRUFTNHdFUVFNSVpKSENLU0NKUG5MTm9l

QUFnRVFnSUlDTTM3dlJ6bjlYT2cwVHhyS0o4NzhsWXJQNi1jUHNyN3oydHhXX0hlV1J4NkZkTnFS

a2RwWFVicjd5WDEzTWxWREszMFRNUTVDRnJsR2ttQUh4c1lOM0JsTGZTUlhGcEFhZFpTcXNTTEYx

b0pVR3lha2FRWUFKM216WUVieDhEN1d2Z213Y0xjSUtuek5Ic1ZUc3Vha2dUSzZfbk9Cd0ZzY2Iw

TEZNam01R2lHdjVqN1YzN3J1eDlTZDBWWUpqcC1Vd0pTTWtvMGQyR1pwcXhGZmFCcWtTaUZiYklP

d2lNdlhoS2h0bmtYcHk5QmRDdXZBZkRuMWRZTXlaY25xX3VGZlpzSWF5VWZSRGhNZzN2cGhOZUtR

SUFSNXg0RUVfWmRfREM1YjhMa2QxTUpiemF3N003VkN1WDhRV2ZwMEFYbW1McUk5bGtDVlN2cGRX

VUFWVDVCZkg4V2NPLVNER19UQms3UWxIYkttbGxjNWhZR0t0czR0NGhzVDBxVXhyYm1jZFlGc2hl

d3J0NDhVRHY1UlEwbGpZZHIwMXZkQ1JfZEZGU21WZWpuaWhtU0diNHYtaFlkM1d5ZU1oZUtCWHVM

Y2R4aEVic1NjSW1kUENteTBTZGpyWHFHQkZFX2dMdElXVE1tYWlDT2NJYUwtWGFjVDloZWNDM2pE

bnIxUTlaZzdranM3aEtpR3dUVTg5YVUtWXBjck9OX2VtVkZRVTRaYTBaZDZxdVB6ZXlsVmpYSnVw

eXZEVVZRZ0Iyb3JSRHdId25yTjlKU1hzcUctcGFqSm9oTk5vS3gwRHI0M2NTd21jTGI2eUxIM29s

b3VuMHVMc25kUlYzV2lNaVlpOUFIR2laTTFJdzdCbUs2SWFXVEd0cVE0Qk55dG9kdy13NFc1NWFt

ckJCTlk2ZkprdENmWHlhekZrSFBTTWh2dllCanBVS29icWlQbnV2N0I1Ni1PcW5iM284NjFoYWQw

YXMweVlLWmlXWDNBSG1TVmNpWlc8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNo

YWlyLmNvbS9laHoyMDYucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0z

WkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJB

RENDQW1JR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTXF0OUk4Mmd2X3IxRjlo

VUVBZ0VRZ0lJQ002SnAxcmxjSE81aGkyN0Z0aXVtZFBoSFdGWDBYNDZGSVUtS2hRTG1FTUh1aERZ

dzZxbDd3R05Wc2k2X2lKMm16N1dhNjhUdHBiZkM2WGM3Z3pJaHpEOFBwNTdFV3k5a3c1Qi0yckNl

dFA3cmVkQ05ORFU5c3NhalY4S3FfcGx4T2FxUk51MVhXRzZMc2hWOXhuZy1sa2VnaXowMHUzbENv

amRhZGVGMjV2UUlaYmJIRGk1ZEthV2xCcmFMMW9EZU0zWWZUajQ0elUzUDk1cTRCOEVTMnp1QjVj

dDJ0UGpDX3pVNHQzbU5nUjVoMmpUakJsQ0twME9PbjlhcXBhSFBNRkZULVRRaVVqMHpzQ3lsVWJZ

MzBXMEU1c09lMUZuaXVzMlR2NEpqLTZHZFdmRmlUZGcxOHU5NXNMUGJoM3h0NC1IbjJXMUtBcTFX

NjF3V2lxcXN2eVVpYjdXYTdBeFZTQnU0Q3dVakdqc0FSXzNvRG9mQ0l5Qm0wUHZDbndhSEU0WHZp

d2lJeHhIdGxVM3hNVHVvbXVidk84QzJtcUVrQ3BTMXpGYUgxOHVaWHNVWDd0Qk1SRk5lclVpQmhk

Zk9rYlM4aGZIVTNJYVhZUXdXSzBZRzBXLTJ1Q0NaeEJVdnR0UW1vUDhwZTlhbndDVVlaeTVaTlRV

YWhaeHRnUE4tVkpScklBT28xZUhGU0w3V0lIZDRKbzdRS2xEbEtYVU44TG02SDBndGpZcXM0R3U0

RnROcG8wYmJPRVZLZ29SM0NaTFhsU1djNERGN3ctbEVJVThPOXZrX29NNTU0UWdrRjNJU2kxSThU

SVNuVFVYOTAwYzc3Um80TmUzZ0l6M3FTeGJNUC1kaTFrdTk2dHcwTDN5ZkZ2alR3blhhLU93cU5p

QTg2SHFhR2pUY0lGT3E3VXc3NUlnQ0JOdVJHLXFyTlpqcDRUVGFiWlQ1VzZ2WEdoTWRyQk5MYVZL

UG5UVVloRG1ZTXRZVWxHVTZCRGR2PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20y

PlBNQzY2ODUzMjg8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVy

aGVhcnRqL2VoejIwNjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaHJpc3RlcnNkb3R0aXI8L0F1dGhvcj48WWVhcj4yMDE5

PC9ZZWFyPjxSZWNOdW0+NDA3MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3Vw

ZXJzY3JpcHQiPjg8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDcy

PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZq

eHB6YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkwNjE2MDkiPjQwNzI8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNocmlzdGVyc2RvdHRpciwg

VC48L2F1dGhvcj48YXV0aG9yPlBpcmF1bHQsIEouPC9hdXRob3I+PGF1dGhvcj5HaXN0ZXJhLCBB

LjwvYXV0aG9yPjxhdXRob3I+QmVyZ21hbiwgTy48L2F1dGhvcj48YXV0aG9yPkdhbGxpbmEsIEEu

IEwuPC9hdXRob3I+PGF1dGhvcj5CYXVtZ2FydG5lciwgUi48L2F1dGhvcj48YXV0aG9yPkx1bmRi

ZXJnLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+RXJpa3Nzb24sIFAuPC9hdXRob3I+PGF1dGhvcj5Z

YW4sIFouIFEuPC9hdXRob3I+PGF1dGhvcj5QYXVsc3Nvbi1CZXJuZSwgRy48L2F1dGhvcj48YXV0

aG9yPkhhbnNzb24sIEcuIEsuPC9hdXRob3I+PGF1dGhvcj5PbG9mc3NvbiwgUC4gUy48L2F1dGhv

cj48YXV0aG9yPkhhbGxlLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgTW9sZWN1bGFyIE1lZGljaW5lIGFuZCBTdXJnZXJ5LCBL

YXJvbGluc2thIEluc3RpdHV0ZXQsIEthcm9saW5za2EgVW5pdmVyc2l0eSBIb3NwaXRhbCwgU3Rv

Y2tob2xtLCBTd2VkZW4uJiN4RDtTdC4gRXJpayBFeWUgSG9zcGl0YWwsIFN0b2NraG9sbSwgU3dl

ZGVuLiYjeEQ7Q2FyZGlvdmFzY3VsYXIgTWVkaWNpbmUgVW5pdCwgRGVwYXJ0bWVudCBvZiBNZWRp

Y2luZSwgQ2VudGVyIGZvciBNb2xlY3VsYXIgTWVkaWNpbmUsIEthcm9saW5za2EgSW5zdGl0dXRl

dCBhbmQgS2Fyb2xpbnNrYSBVbml2ZXJzaXR5IEhvc3BpdGFsLCBCaW9jbGluaWN1bSBKODoyMCwg

VmlzaW9uc2dhdGFuIDQsIFN0b2NraG9sbSwgU3dlZGVuLiYjeEQ7UmVjb25zdHJ1Y3RpdmUgUGxh

c3RpYyBTdXJnZXJ5LCBLYXJvbGluc2thIFVuaXZlcnNpdHkgSG9zcGl0YWwsIFN0b2NraG9sbSwg

U3dlZGVuLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlByZXZlbnRpb24gb2YgcmFkaW90

aGVyYXB5LWluZHVjZWQgYXJ0ZXJpYWwgaW5mbGFtbWF0aW9uIGJ5IGludGVybGV1a2luLTEgYmxv

Y2thZGU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+MjQ5NS0yNTAzPC9wYWdlcz48dm9sdW1lPjQwPC92b2x1bWU+PG51

bWJlcj4zMDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbmFraW5yYTwva2V5d29yZD48a2V5

d29yZD5DY2wyPC9rZXl3b3JkPjxrZXl3b3JkPkludGVybGV1a2luLTE8L2tleXdvcmQ+PGtleXdv

cmQ+TWNwLTE8L2tleXdvcmQ+PGtleXdvcmQ+UmFkaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlZh

c2N1bGFyIGRpc2Vhc2U8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVh

cj48cHViLWRhdGVzPjxkYXRlPkF1ZyA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNj

ZXNzaW9uLW51bT4zMTA4MTAzODwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1

cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzEwODEwMzg8L3VybD48dXJs

Pmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcG1jL2FydGljbGVzL1BNQzY2ODUzMjgvcGRm

L2VoejIwNi5wZGY8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9l

aHoyMDYucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3Fm

S0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJBRENDQW1JR0NT

cUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTVFEeDJfSjE1cFRyUnV4MEhBZ0VRZ0lJ

Q002WW5aTGhocnpuenBsay1XQjl1Zzg5QkNfaDgxUDhqSDBqaVBGZGY4ekNkZkE4d1h0aG1ZaTJF

em5aVFl2QmIxZmRQbE4xT0I3ZmR3Ui1jeXNpa19FUVA2R1Y3NUw2Z0FOT1lfamVteUYxaHM3LUdU

Y0FlVHFkOXN5aDFmbThTMkQta01SdXd6eVBJYURQUUI3dlBLQTJvYzNBWENUM2lzajE2WEh0VFpN

dUxBVUxXSGY1WkpqdkpUbXdlamVWb0VnODI5Q2o4VGhBTG5YSU5WY19MQWRrVGdKbTV1TTFKcnRI

ZDZOeks5X0hIR2VISjVld1VxMWR2LXI1d0FrcXdNQUt0LU9JRl9UejBvZWJRb2lYX1RhLThGdmF1

OXFrU1Fzcjg0dEpkTmxkUGxaM1VaZmlwQy1uOVlTUkdtU0I3RFlpbHdGV2FuQXdvSHZXUHBGWDVG

WHh0anNzX0xiVjZIWEc3UmlUcE1IT2VVdXlXZEZfSWd2eFRvd1ZVRDRMcU5DVkJSa0dZd2twSDBW

NW9wd3VIUzlLM3ZWbC1IZE1iOC1GckZnUnUwRkM1SUR3WHp2cXZwOGVOcmZTbzZZeHd1SUpqZjFz

eURlS3JlVlpOc3ZKTGgyU1V4c1ZxRFZRaDFfeG43Xzl3WHp4STdiRklmY2ZuNE1FSGV2cjdrMFhz

VVNMUzJicm1vUGljRkhVZkJ1RURiMDFseHM4NHFua2NLNjd0eTduTFhnTjh3MGJxMzNGZEVBV3JK

RnRNMTVIWVlNTm54VzV3TXhxbi1oeVBZcm54MXJzM2tHd2xWbDlCcXhFVTZDeU9TZDNJZ3QtdDBf

Mm1KRWRxYlJuTlUtQjhSWG1tSUw1UWVtUThSVXB1Y1JTdkZLS2VzQk9aWkRIT0ZtbmZEb1JxWDVN

MENNN0hjVWJzNnhydklQdGc1cXdzUWIzQV9nVTREdV9hZHBQdjhtWEhHc3pQOVoxR1lpemNqNFE1

SjVEZElZV1h0cWdpPC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3BtYy9h

cnRpY2xlcy9QTUM2Njg1MzI4LzwvdXJsPjx1cmw+aHR0cHM6Ly93YXRlcm1hcmsuc2lsdmVyY2hh

aXIuY29tL2VoejIwNi5wZGY/dG9rZW49QVFFQ0FIaTIwOEJFNDlPb2FuOWtraFdfRXJjeTdEbTNa

TF85Q2YzcWZLQWM0ODV5c2dBQUFvQXdnZ0o4QmdrcWhraUc5dzBCQndhZ2dnSnRNSUlDYVFJQkFE

Q0NBbUlHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFNRUFTNHdFUVFNSVpKSENLU0NKUG5MTm9l

QUFnRVFnSUlDTTM3dlJ6bjlYT2cwVHhyS0o4NzhsWXJQNi1jUHNyN3oydHhXX0hlV1J4NkZkTnFS

a2RwWFVicjd5WDEzTWxWREszMFRNUTVDRnJsR2ttQUh4c1lOM0JsTGZTUlhGcEFhZFpTcXNTTEYx

b0pVR3lha2FRWUFKM216WUVieDhEN1d2Z213Y0xjSUtuek5Ic1ZUc3Vha2dUSzZfbk9Cd0ZzY2Iw

TEZNam01R2lHdjVqN1YzN3J1eDlTZDBWWUpqcC1Vd0pTTWtvMGQyR1pwcXhGZmFCcWtTaUZiYklP

d2lNdlhoS2h0bmtYcHk5QmRDdXZBZkRuMWRZTXlaY25xX3VGZlpzSWF5VWZSRGhNZzN2cGhOZUtR

SUFSNXg0RUVfWmRfREM1YjhMa2QxTUpiemF3N003VkN1WDhRV2ZwMEFYbW1McUk5bGtDVlN2cGRX

VUFWVDVCZkg4V2NPLVNER19UQms3UWxIYkttbGxjNWhZR0t0czR0NGhzVDBxVXhyYm1jZFlGc2hl

d3J0NDhVRHY1UlEwbGpZZHIwMXZkQ1JfZEZGU21WZWpuaWhtU0diNHYtaFlkM1d5ZU1oZUtCWHVM

Y2R4aEVic1NjSW1kUENteTBTZGpyWHFHQkZFX2dMdElXVE1tYWlDT2NJYUwtWGFjVDloZWNDM2pE

bnIxUTlaZzdranM3aEtpR3dUVTg5YVUtWXBjck9OX2VtVkZRVTRaYTBaZDZxdVB6ZXlsVmpYSnVw

eXZEVVZRZ0Iyb3JSRHdId25yTjlKU1hzcUctcGFqSm9oTk5vS3gwRHI0M2NTd21jTGI2eUxIM29s

b3VuMHVMc25kUlYzV2lNaVlpOUFIR2laTTFJdzdCbUs2SWFXVEd0cVE0Qk55dG9kdy13NFc1NWFt

ckJCTlk2ZkprdENmWHlhekZrSFBTTWh2dllCanBVS29icWlQbnV2N0I1Ni1PcW5iM284NjFoYWQw

YXMweVlLWmlXWDNBSG1TVmNpWlc8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNo

YWlyLmNvbS9laHoyMDYucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0z

WkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJB

RENDQW1JR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTXF0OUk4Mmd2X3IxRjlo

VUVBZ0VRZ0lJQ002SnAxcmxjSE81aGkyN0Z0aXVtZFBoSFdGWDBYNDZGSVUtS2hRTG1FTUh1aERZ

dzZxbDd3R05Wc2k2X2lKMm16N1dhNjhUdHBiZkM2WGM3Z3pJaHpEOFBwNTdFV3k5a3c1Qi0yckNl

dFA3cmVkQ05ORFU5c3NhalY4S3FfcGx4T2FxUk51MVhXRzZMc2hWOXhuZy1sa2VnaXowMHUzbENv

amRhZGVGMjV2UUlaYmJIRGk1ZEthV2xCcmFMMW9EZU0zWWZUajQ0elUzUDk1cTRCOEVTMnp1QjVj

dDJ0UGpDX3pVNHQzbU5nUjVoMmpUakJsQ0twME9PbjlhcXBhSFBNRkZULVRRaVVqMHpzQ3lsVWJZ

MzBXMEU1c09lMUZuaXVzMlR2NEpqLTZHZFdmRmlUZGcxOHU5NXNMUGJoM3h0NC1IbjJXMUtBcTFX

NjF3V2lxcXN2eVVpYjdXYTdBeFZTQnU0Q3dVakdqc0FSXzNvRG9mQ0l5Qm0wUHZDbndhSEU0WHZp

d2lJeHhIdGxVM3hNVHVvbXVidk84QzJtcUVrQ3BTMXpGYUgxOHVaWHNVWDd0Qk1SRk5lclVpQmhk

Zk9rYlM4aGZIVTNJYVhZUXdXSzBZRzBXLTJ1Q0NaeEJVdnR0UW1vUDhwZTlhbndDVVlaeTVaTlRV

YWhaeHRnUE4tVkpScklBT28xZUhGU0w3V0lIZDRKbzdRS2xEbEtYVU44TG02SDBndGpZcXM0R3U0

RnROcG8wYmJPRVZLZ29SM0NaTFhsU1djNERGN3ctbEVJVThPOXZrX29NNTU0UWdrRjNJU2kxSThU

SVNuVFVYOTAwYzc3Um80TmUzZ0l6M3FTeGJNUC1kaTFrdTk2dHcwTDN5ZkZ2alR3blhhLU93cU5p

QTg2SHFhR2pUY0lGT3E3VXc3NUlnQ0JOdVJHLXFyTlpqcDRUVGFiWlQ1VzZ2WEdoTWRyQk5MYVZL

UG5UVVloRG1ZTXRZVWxHVTZCRGR2PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20y

PlBNQzY2ODUzMjg8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVy

aGVhcnRqL2VoejIwNjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE.DATA 8 In the model, the localized inflammatory response was ameliorated by treatment with an IL-1 receptor antagonist. Clinical studies in humans now need to evaluate IL-1 blockade as a potential treatment of radiotherapy-induced CVD. Deciding time of intervention so as not to ameliorate the radiotherapy benefits will be crucial.Subjects with Lp(a) elevation have increased arterial wall inflammation and cardiovascular risk. Stiekema et alPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGlla2VtYTwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+

PFJlY051bT40MDc0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+OTwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwNzQ8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2Vz

MnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTA2MjA5OCI+NDA3NDwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U3RpZWtlbWEsIEwuIEMuIEEuPC9hdXRo

b3I+PGF1dGhvcj5TdHJvZXMsIEUuIFMuIEcuPC9hdXRob3I+PGF1dGhvcj5WZXJ3ZWlqLCBTLiBM

LjwvYXV0aG9yPjxhdXRob3I+S2Fzc2FodW4sIEguPC9hdXRob3I+PGF1dGhvcj5DaGVuLCBMLjwv

YXV0aG9yPjxhdXRob3I+V2Fzc2VybWFuLCBTLiBNLjwvYXV0aG9yPjxhdXRob3I+U2FiYXRpbmUs

IE0uIFMuPC9hdXRob3I+PGF1dGhvcj5NYW5pLCBWLjwvYXV0aG9yPjxhdXRob3I+RmF5YWQsIFou

IEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0

bWVudCBvZiBWYXNjdWxhciBNZWRpY2luZSwgQW1zdGVyZGFtIFVuaXZlcnNpdHkgTWVkaWNhbCBD

ZW50ZXIsIFVuaXZlcnNpdHkgb2YgQW1zdGVyZGFtLCBNZWliZXJnZHJlZWYgOSwgQVogQW1zdGVy

ZGFtLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtEZXBhcnRtZW50IG9mIENsaW5pY2FsIERldmVsb3Bt

ZW50LCBBbWdlbiBJbmMuLCBPbmUgQW1nZW4gQ2VudGVyIERyaXZlIFRob3VzYW5kIE9ha3MsIENB

LCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIEJpb3N0YXRpc3RpY3MsIEFtZ2VuIEluYy4sIE9uZSBB

bWdlbiBDZW50ZXIgRHJpdmUgVGhvdXNhbmQgT2FrcywgQ0EsIFVTQS4mI3hEO0RpdmlzaW9uIG9m

IENhcmRpb3Zhc2N1bGFyIE1lZGljaW5lLCBUSU1JIFN0dWR5IEdyb3VwLCBCcmlnaGFtIGFuZCBX

b21lbiZhcG9zO3MgSG9zcGl0YWwgYW5kIEhhcnZhcmQgTWVkaWNhbCBTY2hvb2wsIEZlbndvb2Qg

Um9hZCwgQm9zdG9uLCBNQSwgVVNBLiYjeEQ7VHJhbnNsYXRpb25hbCBhbmQgTW9sZWN1bGFyIElt

YWdpbmcgSW5zdGl0dXRlLCBJY2FobiBTY2hvb2wgb2YgTWVkaWNpbmUgYXQgTW91bnQgU2luYWks

IE9uZSBHdXN0YXZlIEwuIExldnkgUGwsIE5ldyBZb3JrLCBOWSwgVVNBLjwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPlBlcnNpc3RlbnQgYXJ0ZXJpYWwgd2FsbCBpbmZsYW1tYXRpb24gaW4g

cGF0aWVudHMgd2l0aCBlbGV2YXRlZCBsaXBvcHJvdGVpbihhKSBkZXNwaXRlIHN0cm9uZyBsb3ct

ZGVuc2l0eSBsaXBvcHJvdGVpbiBjaG9sZXN0ZXJvbCByZWR1Y3Rpb24gYnkgcHJvcHJvdGVpbiBj

b252ZXJ0YXNlIHN1YnRpbGlzaW4va2V4aW4gdHlwZSA5IGFudGlib2R5IHRyZWF0bWVudDwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVz

PjxwYWdlcz4yNzc1LTI3ODE8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48bnVtYmVyPjMzPC9u

dW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFydGVyaWFsIHdhbGwgaW5mbGFtbWF0aW9uPC9rZXl3

b3JkPjxrZXl3b3JkPkF0aGVyb3NjbGVyb3Npczwva2V5d29yZD48a2V5d29yZD5Fdm9sb2N1bWFi

PC9rZXl3b3JkPjxrZXl3b3JkPkxpcG9wcm90ZWluKGEpPC9rZXl3b3JkPjxrZXl3b3JkPlBDU0s5

IGFudGlib2RpZXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48

cHViLWRhdGVzPjxkYXRlPlNlcCAxPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUy

Mi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNz

aW9uLW51bT4zMDU2MTYxMDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzA1NjE2MTA8L3VybD48dXJsPmh0

dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9laHk4NjIucGRmP3Rva2VuPUFRRUNBSGky

MDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Fo

a2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJBRENDQW1JR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpR

TUVBUzR3RVFRTWpjdThaX0QzYkxrdmVUWWJBZ0VRZ0lJQ004WXJFaTNBbGNrOUNtamVvZnh1LWxB

S01ZbWcxNVJMUTZ4aU9IbDI5SGhHTXRBZjRxZXRmaWFzREhqQlhHTUJ5bzFfUHRFUzJSR1BrZnRT

N0dpcm1MNS01Z3U1U2dtbG1XSzhrYVdZUFJyRmZUS1lrWGVuV21rbTQteC1MeFFGTXNpaXAzbmlr

STh4YlhreEo0UlFMbkRTRkFEY3cxZ2NxT1p1YXZ1SlhELWNJQzlNejk3em96RWN2RVIwcHJSVnl4

RDYzdzYyYkc0SWxfVWNFdGpGeDJGY2czcERwajE5QVBNYXRFRUFXaVMwbnVwUmJlYWVhUmk3Tm1Q

SkhQVk5LdjdaN2Y3ZUFnLXcwNmxoM2pValJ0bWtremlKT0NybHRPb2pFVkRyN0NCQV9JOTFSN3ZV

YjdYTjZ2SzBhNmNvbFdRc0FxUWdWN2hmYjdzMmYtamFsTmt2NXVtUjZQUXdDOHpTNW9Pemh5WnZN

T3hqT0tXelpGSVpBMzFJN2ozQmtISnRNeVJ3al9CRTRWRUhibGlHbjNSU3V0QlREV2QtN2toY2d1

Rl8tckVVRGswazVCcnRSVUZOVXpOazl6aWQwaG1rYU5OcXJqVFRWRlQzQi1GcUVEQUNNR0RQOU4z

akE4cHNvUnZBWTdGZW1SX1czMEdjWWZ4U2lITG9BRTZ5bkZQb1FYQ2djYnl0dWU3LU5VZG40S001

SDlwaXl2QldhUlZfM1ZVR1FFdFh1Z1NGSXhvRUlhMnloaWRWVXJ2YTdpai1Vd1E2bjNNM2gxNEJL

dDdCbUk2WGI2S0ZRNGc1S29kdUJRODVRQWI3RnpLRzJBaU5KaklqbEpISjd5b19YNzJ5bkpOanB4

c2FaN29BQUMtTjgyeGwwX3RzaVlxYzJpSmhrS1Z4QThkcDJwZjN5aVY4OEg4N0lzQ1BTNGlJMERN

LWJ2RW9xek9ycjN2by1uY1NiR0xsb2k5SUYycFp2cFg5RlRHV2pkaldQRWdCPC91cmw+PC9yZWxh

dGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0

ai9laHk4NjI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5v

dGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGlla2VtYTwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+

PFJlY051bT40MDc0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+OTwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwNzQ8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2Vz

MnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTA2MjA5OCI+NDA3NDwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U3RpZWtlbWEsIEwuIEMuIEEuPC9hdXRo

b3I+PGF1dGhvcj5TdHJvZXMsIEUuIFMuIEcuPC9hdXRob3I+PGF1dGhvcj5WZXJ3ZWlqLCBTLiBM

LjwvYXV0aG9yPjxhdXRob3I+S2Fzc2FodW4sIEguPC9hdXRob3I+PGF1dGhvcj5DaGVuLCBMLjwv

YXV0aG9yPjxhdXRob3I+V2Fzc2VybWFuLCBTLiBNLjwvYXV0aG9yPjxhdXRob3I+U2FiYXRpbmUs

IE0uIFMuPC9hdXRob3I+PGF1dGhvcj5NYW5pLCBWLjwvYXV0aG9yPjxhdXRob3I+RmF5YWQsIFou

IEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0

bWVudCBvZiBWYXNjdWxhciBNZWRpY2luZSwgQW1zdGVyZGFtIFVuaXZlcnNpdHkgTWVkaWNhbCBD

ZW50ZXIsIFVuaXZlcnNpdHkgb2YgQW1zdGVyZGFtLCBNZWliZXJnZHJlZWYgOSwgQVogQW1zdGVy

ZGFtLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtEZXBhcnRtZW50IG9mIENsaW5pY2FsIERldmVsb3Bt

ZW50LCBBbWdlbiBJbmMuLCBPbmUgQW1nZW4gQ2VudGVyIERyaXZlIFRob3VzYW5kIE9ha3MsIENB

LCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIEJpb3N0YXRpc3RpY3MsIEFtZ2VuIEluYy4sIE9uZSBB

bWdlbiBDZW50ZXIgRHJpdmUgVGhvdXNhbmQgT2FrcywgQ0EsIFVTQS4mI3hEO0RpdmlzaW9uIG9m

IENhcmRpb3Zhc2N1bGFyIE1lZGljaW5lLCBUSU1JIFN0dWR5IEdyb3VwLCBCcmlnaGFtIGFuZCBX

b21lbiZhcG9zO3MgSG9zcGl0YWwgYW5kIEhhcnZhcmQgTWVkaWNhbCBTY2hvb2wsIEZlbndvb2Qg

Um9hZCwgQm9zdG9uLCBNQSwgVVNBLiYjeEQ7VHJhbnNsYXRpb25hbCBhbmQgTW9sZWN1bGFyIElt

YWdpbmcgSW5zdGl0dXRlLCBJY2FobiBTY2hvb2wgb2YgTWVkaWNpbmUgYXQgTW91bnQgU2luYWks

IE9uZSBHdXN0YXZlIEwuIExldnkgUGwsIE5ldyBZb3JrLCBOWSwgVVNBLjwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPlBlcnNpc3RlbnQgYXJ0ZXJpYWwgd2FsbCBpbmZsYW1tYXRpb24gaW4g

cGF0aWVudHMgd2l0aCBlbGV2YXRlZCBsaXBvcHJvdGVpbihhKSBkZXNwaXRlIHN0cm9uZyBsb3ct

ZGVuc2l0eSBsaXBvcHJvdGVpbiBjaG9sZXN0ZXJvbCByZWR1Y3Rpb24gYnkgcHJvcHJvdGVpbiBj

b252ZXJ0YXNlIHN1YnRpbGlzaW4va2V4aW4gdHlwZSA5IGFudGlib2R5IHRyZWF0bWVudDwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVz

PjxwYWdlcz4yNzc1LTI3ODE8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48bnVtYmVyPjMzPC9u

dW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFydGVyaWFsIHdhbGwgaW5mbGFtbWF0aW9uPC9rZXl3

b3JkPjxrZXl3b3JkPkF0aGVyb3NjbGVyb3Npczwva2V5d29yZD48a2V5d29yZD5Fdm9sb2N1bWFi

PC9rZXl3b3JkPjxrZXl3b3JkPkxpcG9wcm90ZWluKGEpPC9rZXl3b3JkPjxrZXl3b3JkPlBDU0s5

IGFudGlib2RpZXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48

cHViLWRhdGVzPjxkYXRlPlNlcCAxPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUy

Mi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNz

aW9uLW51bT4zMDU2MTYxMDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzA1NjE2MTA8L3VybD48dXJsPmh0

dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9laHk4NjIucGRmP3Rva2VuPUFRRUNBSGky

MDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Fo

a2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJBRENDQW1JR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpR

TUVBUzR3RVFRTWpjdThaX0QzYkxrdmVUWWJBZ0VRZ0lJQ004WXJFaTNBbGNrOUNtamVvZnh1LWxB

S01ZbWcxNVJMUTZ4aU9IbDI5SGhHTXRBZjRxZXRmaWFzREhqQlhHTUJ5bzFfUHRFUzJSR1BrZnRT

N0dpcm1MNS01Z3U1U2dtbG1XSzhrYVdZUFJyRmZUS1lrWGVuV21rbTQteC1MeFFGTXNpaXAzbmlr

STh4YlhreEo0UlFMbkRTRkFEY3cxZ2NxT1p1YXZ1SlhELWNJQzlNejk3em96RWN2RVIwcHJSVnl4

RDYzdzYyYkc0SWxfVWNFdGpGeDJGY2czcERwajE5QVBNYXRFRUFXaVMwbnVwUmJlYWVhUmk3Tm1Q

SkhQVk5LdjdaN2Y3ZUFnLXcwNmxoM2pValJ0bWtremlKT0NybHRPb2pFVkRyN0NCQV9JOTFSN3ZV

YjdYTjZ2SzBhNmNvbFdRc0FxUWdWN2hmYjdzMmYtamFsTmt2NXVtUjZQUXdDOHpTNW9Pemh5WnZN

T3hqT0tXelpGSVpBMzFJN2ozQmtISnRNeVJ3al9CRTRWRUhibGlHbjNSU3V0QlREV2QtN2toY2d1

Rl8tckVVRGswazVCcnRSVUZOVXpOazl6aWQwaG1rYU5OcXJqVFRWRlQzQi1GcUVEQUNNR0RQOU4z

akE4cHNvUnZBWTdGZW1SX1czMEdjWWZ4U2lITG9BRTZ5bkZQb1FYQ2djYnl0dWU3LU5VZG40S001

SDlwaXl2QldhUlZfM1ZVR1FFdFh1Z1NGSXhvRUlhMnloaWRWVXJ2YTdpai1Vd1E2bjNNM2gxNEJL

dDdCbUk2WGI2S0ZRNGc1S29kdUJRODVRQWI3RnpLRzJBaU5KaklqbEpISjd5b19YNzJ5bkpOanB4

c2FaN29BQUMtTjgyeGwwX3RzaVlxYzJpSmhrS1Z4QThkcDJwZjN5aVY4OEg4N0lzQ1BTNGlJMERN

LWJ2RW9xek9ycjN2by1uY1NiR0xsb2k5SUYycFp2cFg5RlRHV2pkaldQRWdCPC91cmw+PC9yZWxh

dGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0

ai9laHk4NjI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5v

dGU+AG==

ADDIN EN.CITE.DATA 9 evaluated whether evolocumab, which as opposed to statins lowers both LDL-C and Lp(a), attenuates arterial wall inflammation in the index vessel (carotid or thoracic aorta) in patients with elevated Lp(a) (>200 mg/dL). In this multicentre, randomized, double-blind, placebo-controlled study, 129 patients were randomized to monthly subcutaneous evolocumab 420 mg or placebo. Compared with placebo, evolocumab reduced LDL-C by 6.7% (95% confidence interval [CI] 65.8–55.5) and Lp(a) by only 13.8% (95%CI 19.3–8.5). Importantly, arterial wall inflammation (assessed by 18F-FDG PET/CT) was not significantly altered with evolocumab at week 16. This supports that, beyond economic issues, statins remain the first pillar of lipid lowering therapies, which ties in with current lipid guidelines.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWNoPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQwODc8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4x

MDwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwODc8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2VzMnI3

NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTYwNTQyNyI+NDA4Nzwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFjaCwgRi48L2F1dGhvcj48YXV0aG9yPkJh

aWdlbnQsIEMuPC9hdXRob3I+PGF1dGhvcj5DYXRhcGFubywgQS4gTC48L2F1dGhvcj48YXV0aG9y

Pktvc2tpbmFzLCBLLiBDLjwvYXV0aG9yPjxhdXRob3I+Q2FzdWxhLCBNLjwvYXV0aG9yPjxhdXRo

b3I+QmFkaW1vbiwgTC48L2F1dGhvcj48YXV0aG9yPkNoYXBtYW4sIE0uIEouPC9hdXRob3I+PGF1

dGhvcj5EZSBCYWNrZXIsIEcuIEcuPC9hdXRob3I+PGF1dGhvcj5EZWxnYWRvLCBWLjwvYXV0aG9y

PjxhdXRob3I+RmVyZW5jZSwgQi4gQS48L2F1dGhvcj48YXV0aG9yPkdyYWhhbSwgSS4gTS48L2F1

dGhvcj48YXV0aG9yPkhhbGxpZGF5LCBBLjwvYXV0aG9yPjxhdXRob3I+TGFuZG1lc3NlciwgVS48

L2F1dGhvcj48YXV0aG9yPk1paGF5bG92YSwgQi48L2F1dGhvcj48YXV0aG9yPlBlZGVyc2VuLCBU

LiBSLjwvYXV0aG9yPjxhdXRob3I+UmljY2FyZGksIEcuPC9hdXRob3I+PGF1dGhvcj5SaWNodGVy

LCBELiBKLjwvYXV0aG9yPjxhdXRob3I+U2FiYXRpbmUsIE0uIFMuPC9hdXRob3I+PGF1dGhvcj5U

YXNraW5lbiwgTS4gUi48L2F1dGhvcj48YXV0aG9yPlRva2dvem9nbHUsIEwuPC9hdXRob3I+PGF1

dGhvcj5XaWtsdW5kLCBPLjwvYXV0aG9yPjxhdXRob3I+RS4gUy4gQy4gU2NpZW50aWZpYyBEb2N1

bWVudCBHcm91cDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRs

ZT4yMDE5IEVTQy9FQVMgR3VpZGVsaW5lcyBmb3IgdGhlIG1hbmFnZW1lbnQgb2YgZHlzbGlwaWRh

ZW1pYXM6IGxpcGlkIG1vZGlmaWNhdGlvbiB0byByZWR1Y2UgY2FyZGlvdmFzY3VsYXIgcmlzazwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0

bGVzPjxrZXl3b3Jkcz48a2V5d29yZD5HdWlkZWxpbmVzPC9rZXl3b3JkPjxrZXl3b3JkPmFwb2xp

cG9wcm90ZWluIEI8L2tleXdvcmQ+PGtleXdvcmQ+Y2hvbGVzdGVyb2w8L2tleXdvcmQ+PGtleXdv

cmQ+ZHlzbGlwaWRhZW1pYXM8L2tleXdvcmQ+PGtleXdvcmQ+ZmFtaWxpYWwgaHlwZXJjaG9sZXN0

ZXJvbGFlbWlhPC9rZXl3b3JkPjxrZXl3b3JkPmhpZ2gtZGVuc2l0eSBsaXBvcHJvdGVpbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+bGlwb3Byb3RlaW4gcmVtbmFudHM8L2tleXdvcmQ+PGtleXdvcmQ+bGlw

b3Byb3RlaW4oYSk8L2tleXdvcmQ+PGtleXdvcmQ+bG93LWRlbnNpdHkgbGlwb3Byb3RlaW5zPC9r

ZXl3b3JkPjxrZXl3b3JkPnRvdGFsIGNhcmRpb3Zhc2N1bGFyIHJpc2s8L2tleXdvcmQ+PGtleXdv

cmQ+dHJlYXRtZW50IChhZGhlcmVuY2UpPC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCAoZHJ1

Z3MpPC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCAobGlmZXN0eWxlKTwva2V5d29yZD48a2V5

d29yZD50cmlnbHljZXJpZGVzPC9rZXl3b3JkPjxrZXl3b3JkPnZlcnkgbG93LWRlbnNpdHkgbGlw

b3Byb3RlaW5zPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1

Yi1kYXRlcz48ZGF0ZT5BdWcgMzE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIy

LTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Np

b24tbnVtPjMxNTA0NDE4PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMTUwNDQxODwvdXJsPjx1cmw+aHR0

cHM6Ly93YXRlcm1hcmsuc2lsdmVyY2hhaXIuY29tL2VoejQ1NS5wZGY/dG9rZW49QVFFQ0FIaTIw

OEJFNDlPb2FuOWtraFdfRXJjeTdEbTNaTF85Q2YzcWZLQWM0ODV5c2dBQUFvUXdnZ0tBQmdrcWhr

aUc5dzBCQndhZ2dnSnhNSUlDYlFJQkFEQ0NBbVlHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFN

RUFTNHdFUVFNY3h4cEllLWxreXJYSjNMLUFnRVFnSUlDTnpCaG1ySnc5UGhpcUVGR0NfZm90TXZk

a3hMNjRwd0o5dUdkeC1PNUpqWGpMUDR4SV8xQWl6RDVMcE1TNDR4d0VNUmYzMUFsX01sOHJrS3My

UzVPWl8ycFZ6SHNCSG50LWNkYkRIcERlcllYZ0w1eFB0MV8yMWVLS0J2eDJRMHo1VW5Ha2ZLeC1u

VDEzY29mS0Q3bXBnVnp4YnE2U2pORER5U0VSTm1HeXBRMkZvWllBbjFyMi11Z0hzTFd5TVk4eDdI

TzVwVnZTZXhDT3I0eE1rMGo5bC0zOFVhRFM5NzE3SGhES0ktbzZRNEFxNi1Jb3MtVWhWTnZKX292

eU56cHlqSWVMOG82MFRfTWdpZmZteEhnY3NXS1pBUGZhLVQ4N0tBOEJDSGNoeXpCejBRbmZWcUE5

VU5fRXZZVEVWb1pDYXNTLWZQU1MyZmNXbHc3OFNiVzk1ck1fMmoxVUFWRkw5cDVlLWoxMjdoR2hy

Sk9LUF9iM0hxOXdhcm5OREZRRGwwaWdJdlVzOTFFQ2RoWmVtaGh2c21Ka3Ixc2xQcTA2eEhpenI3

Mk5wcW41Z3E5WktycXhsZWNoekJaR0ktQjJhbEFpb280VmM4djF1YXU4blRrZzFQXzJzbDlsTmFF

QWFzdEtpM2owNmNZdVEzMjVVVGlSUjZRNlNPbjNiS0tnWGlVeVdELVFneFI2RHBxbER3MldRbXRx

OGtyR3VobTZETXY1OWE5VEZfWG85cE5FWXJFLVlVeXdObklkUE1ISnFjczFJLUtPQ1Z4dC1HNk9j

cF9nTFNRYkZzREJYWTVTTno4N19wSVBndTFYMnpWSnJNTGZyd1N1bzFUdnhsaWs1VUNVdHhxV1FQ

Y2tQb1c5SU5OUk5RcS0wVjFpbW9LUUJ2aC1Iel9NNUdqYVFsclNHS1BoT2QxY3ZVX0kxeHNXYVdn

LTBWT1RGTk9ScWQ1Z0JrdGlhVUpMQW11b0ViN1l6Z1VfLVZ6dDM0RnlwMjA3Nk1BMEE8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVy

aGVhcnRqL2VoejQ1NTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWNoPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQwODc8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4x

MDwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwODc8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2VzMnI3

NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTYwNTQyNyI+NDA4Nzwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFjaCwgRi48L2F1dGhvcj48YXV0aG9yPkJh

aWdlbnQsIEMuPC9hdXRob3I+PGF1dGhvcj5DYXRhcGFubywgQS4gTC48L2F1dGhvcj48YXV0aG9y

Pktvc2tpbmFzLCBLLiBDLjwvYXV0aG9yPjxhdXRob3I+Q2FzdWxhLCBNLjwvYXV0aG9yPjxhdXRo

b3I+QmFkaW1vbiwgTC48L2F1dGhvcj48YXV0aG9yPkNoYXBtYW4sIE0uIEouPC9hdXRob3I+PGF1

dGhvcj5EZSBCYWNrZXIsIEcuIEcuPC9hdXRob3I+PGF1dGhvcj5EZWxnYWRvLCBWLjwvYXV0aG9y

PjxhdXRob3I+RmVyZW5jZSwgQi4gQS48L2F1dGhvcj48YXV0aG9yPkdyYWhhbSwgSS4gTS48L2F1

dGhvcj48YXV0aG9yPkhhbGxpZGF5LCBBLjwvYXV0aG9yPjxhdXRob3I+TGFuZG1lc3NlciwgVS48

L2F1dGhvcj48YXV0aG9yPk1paGF5bG92YSwgQi48L2F1dGhvcj48YXV0aG9yPlBlZGVyc2VuLCBU

LiBSLjwvYXV0aG9yPjxhdXRob3I+UmljY2FyZGksIEcuPC9hdXRob3I+PGF1dGhvcj5SaWNodGVy

LCBELiBKLjwvYXV0aG9yPjxhdXRob3I+U2FiYXRpbmUsIE0uIFMuPC9hdXRob3I+PGF1dGhvcj5U

YXNraW5lbiwgTS4gUi48L2F1dGhvcj48YXV0aG9yPlRva2dvem9nbHUsIEwuPC9hdXRob3I+PGF1

dGhvcj5XaWtsdW5kLCBPLjwvYXV0aG9yPjxhdXRob3I+RS4gUy4gQy4gU2NpZW50aWZpYyBEb2N1

bWVudCBHcm91cDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRs

ZT4yMDE5IEVTQy9FQVMgR3VpZGVsaW5lcyBmb3IgdGhlIG1hbmFnZW1lbnQgb2YgZHlzbGlwaWRh

ZW1pYXM6IGxpcGlkIG1vZGlmaWNhdGlvbiB0byByZWR1Y2UgY2FyZGlvdmFzY3VsYXIgcmlzazwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0

bGVzPjxrZXl3b3Jkcz48a2V5d29yZD5HdWlkZWxpbmVzPC9rZXl3b3JkPjxrZXl3b3JkPmFwb2xp

cG9wcm90ZWluIEI8L2tleXdvcmQ+PGtleXdvcmQ+Y2hvbGVzdGVyb2w8L2tleXdvcmQ+PGtleXdv

cmQ+ZHlzbGlwaWRhZW1pYXM8L2tleXdvcmQ+PGtleXdvcmQ+ZmFtaWxpYWwgaHlwZXJjaG9sZXN0

ZXJvbGFlbWlhPC9rZXl3b3JkPjxrZXl3b3JkPmhpZ2gtZGVuc2l0eSBsaXBvcHJvdGVpbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+bGlwb3Byb3RlaW4gcmVtbmFudHM8L2tleXdvcmQ+PGtleXdvcmQ+bGlw

b3Byb3RlaW4oYSk8L2tleXdvcmQ+PGtleXdvcmQ+bG93LWRlbnNpdHkgbGlwb3Byb3RlaW5zPC9r

ZXl3b3JkPjxrZXl3b3JkPnRvdGFsIGNhcmRpb3Zhc2N1bGFyIHJpc2s8L2tleXdvcmQ+PGtleXdv

cmQ+dHJlYXRtZW50IChhZGhlcmVuY2UpPC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCAoZHJ1

Z3MpPC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCAobGlmZXN0eWxlKTwva2V5d29yZD48a2V5

d29yZD50cmlnbHljZXJpZGVzPC9rZXl3b3JkPjxrZXl3b3JkPnZlcnkgbG93LWRlbnNpdHkgbGlw

b3Byb3RlaW5zPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1

Yi1kYXRlcz48ZGF0ZT5BdWcgMzE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIy

LTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Np

b24tbnVtPjMxNTA0NDE4PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMTUwNDQxODwvdXJsPjx1cmw+aHR0

cHM6Ly93YXRlcm1hcmsuc2lsdmVyY2hhaXIuY29tL2VoejQ1NS5wZGY/dG9rZW49QVFFQ0FIaTIw

OEJFNDlPb2FuOWtraFdfRXJjeTdEbTNaTF85Q2YzcWZLQWM0ODV5c2dBQUFvUXdnZ0tBQmdrcWhr

aUc5dzBCQndhZ2dnSnhNSUlDYlFJQkFEQ0NBbVlHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFN

RUFTNHdFUVFNY3h4cEllLWxreXJYSjNMLUFnRVFnSUlDTnpCaG1ySnc5UGhpcUVGR0NfZm90TXZk

a3hMNjRwd0o5dUdkeC1PNUpqWGpMUDR4SV8xQWl6RDVMcE1TNDR4d0VNUmYzMUFsX01sOHJrS3My

UzVPWl8ycFZ6SHNCSG50LWNkYkRIcERlcllYZ0w1eFB0MV8yMWVLS0J2eDJRMHo1VW5Ha2ZLeC1u

VDEzY29mS0Q3bXBnVnp4YnE2U2pORER5U0VSTm1HeXBRMkZvWllBbjFyMi11Z0hzTFd5TVk4eDdI

TzVwVnZTZXhDT3I0eE1rMGo5bC0zOFVhRFM5NzE3SGhES0ktbzZRNEFxNi1Jb3MtVWhWTnZKX292

eU56cHlqSWVMOG82MFRfTWdpZmZteEhnY3NXS1pBUGZhLVQ4N0tBOEJDSGNoeXpCejBRbmZWcUE5

VU5fRXZZVEVWb1pDYXNTLWZQU1MyZmNXbHc3OFNiVzk1ck1fMmoxVUFWRkw5cDVlLWoxMjdoR2hy

Sk9LUF9iM0hxOXdhcm5OREZRRGwwaWdJdlVzOTFFQ2RoWmVtaGh2c21Ka3Ixc2xQcTA2eEhpenI3

Mk5wcW41Z3E5WktycXhsZWNoekJaR0ktQjJhbEFpb280VmM4djF1YXU4blRrZzFQXzJzbDlsTmFF

QWFzdEtpM2owNmNZdVEzMjVVVGlSUjZRNlNPbjNiS0tnWGlVeVdELVFneFI2RHBxbER3MldRbXRx

OGtyR3VobTZETXY1OWE5VEZfWG85cE5FWXJFLVlVeXdObklkUE1ISnFjczFJLUtPQ1Z4dC1HNk9j

cF9nTFNRYkZzREJYWTVTTno4N19wSVBndTFYMnpWSnJNTGZyd1N1bzFUdnhsaWs1VUNVdHhxV1FQ

Y2tQb1c5SU5OUk5RcS0wVjFpbW9LUUJ2aC1Iel9NNUdqYVFsclNHS1BoT2QxY3ZVX0kxeHNXYVdn

LTBWT1RGTk9ScWQ1Z0JrdGlhVUpMQW11b0ViN1l6Z1VfLVZ6dDM0RnlwMjA3Nk1BMEE8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVy

aGVhcnRqL2VoejQ1NTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE.DATA 10Another large study characterized serum metabolic signatures associated with atherosclerosis in the carotid and coronary arteries and subsequently their association with incident cardiovascular disease among 3,867 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), with replication among 3569 participants from the Rotterdam and LOLIPOP studies.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Uem91bGFraTwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+

PFJlY051bT40MDc3PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+MTE8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDc3PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNl

czJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkwNjMxMzYiPjQwNzc8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlR6b3VsYWtpLCBJLjwvYXV0aG9yPjxh

dXRob3I+Q2FzdGFnbmUsIFIuPC9hdXRob3I+PGF1dGhvcj5Cb3VsYW5nZSwgQy4gTC48L2F1dGhv

cj48YXV0aG9yPkthcmFtYW4sIEkuPC9hdXRob3I+PGF1dGhvcj5DaGVrbWVuZXZhLCBFLjwvYXV0

aG9yPjxhdXRob3I+RXZhbmdlbG91LCBFLjwvYXV0aG9yPjxhdXRob3I+RWJiZWxzLCBULiBNLiBE

LjwvYXV0aG9yPjxhdXRob3I+S2FsdWFyYWNoY2hpLCBNLiBSLjwvYXV0aG9yPjxhdXRob3I+Q2hh

ZGVhdS1IeWFtLCBNLjwvYXV0aG9yPjxhdXRob3I+TW9zZW4sIEQuPC9hdXRob3I+PGF1dGhvcj5E

ZWhnaGFuLCBBLjwvYXV0aG9yPjxhdXRob3I+TW9heXllcmksIEEuPC9hdXRob3I+PGF1dGhvcj5G

ZXJyZWlyYSwgRC4gTC4gUy48L2F1dGhvcj48YXV0aG9yPkd1bywgWC48L2F1dGhvcj48YXV0aG9y

PlJvdHRlciwgSi4gSS48L2F1dGhvcj48YXV0aG9yPlRheWxvciwgSy4gRC48L2F1dGhvcj48YXV0

aG9yPkthdm91c2ksIE0uPC9hdXRob3I+PGF1dGhvcj5kZSBWcmllcywgUC4gUy48L2F1dGhvcj48

YXV0aG9yPkxlaG5lLCBCLjwvYXV0aG9yPjxhdXRob3I+TG9oLCBNLjwvYXV0aG9yPjxhdXRob3I+

SG9mbWFuLCBBLjwvYXV0aG9yPjxhdXRob3I+TmljaG9sc29uLCBKLiBLLjwvYXV0aG9yPjxhdXRo

b3I+Q2hhbWJlcnMsIEouPC9hdXRob3I+PGF1dGhvcj5HaWVnZXIsIEMuPC9hdXRob3I+PGF1dGhv

cj5Ib2xtZXMsIEUuPC9hdXRob3I+PGF1dGhvcj5UcmFjeSwgUi48L2F1dGhvcj48YXV0aG9yPktv

b25lciwgSi48L2F1dGhvcj48YXV0aG9yPkdyZWVubGFuZCwgUC48L2F1dGhvcj48YXV0aG9yPkZy

YW5jbywgTy4gSC48L2F1dGhvcj48YXV0aG9yPkhlcnJpbmd0b24sIEQuPC9hdXRob3I+PGF1dGhv

cj5MaW5kb24sIEouIEMuPC9hdXRob3I+PGF1dGhvcj5FbGxpb3R0LCBQLjwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgRXBpZGVtaW9s

b2d5IGFuZCBCaW9zdGF0aXN0aWNzLCBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCwgSW1wZXJpYWwg

Q29sbGVnZSBMb25kb24sIE5vcmZvbGsgUGxhY2UsIExvbmRvbiwgVUsuJiN4RDtNUkMtUEhFIENl

bnRyZSBmb3IgRW52aXJvbm1lbnQgYW5kIEhlYWx0aCwgU2Nob29sIG9mIFB1YmxpYyBIZWFsdGgs

IEltcGVyaWFsIENvbGxlZ2UgTG9uZG9uLCBOb3Jmb2xrIFBsYWNlLCBMb25kb24sIFVLLiYjeEQ7

RGVwYXJ0bWVudCBvZiBIeWdpZW5lIGFuZCBFcGlkZW1pb2xvZ3ksIFVuaXZlcnNpdHkgb2YgSW9h

bm5pbmEgTWVkaWNhbCBTY2hvb2wsIFVuaXZlcnNpdHkgQ2FtcHVzIFJvYWQgNDU1IDAwLCBJb2Fu

bmluYSwgR3JlZWNlLiYjeEQ7RGVtZW50aWEgUmVzZWFyY2ggSW5zdGl0dXRlLCBJbXBlcmlhbCBD

b2xsZWdlIExvbmRvbiwgTm9yZm9sayBQbGFjZSwgTG9uZG9uLCBVSy4mI3hEO0xFQVNQLCBVTVIg

MTAyNywgSW5zZXJtLVVuaXZlcnNpdGUgVG91bG91c3NlIElJSSBQYXVsIFNhYmF0aWVyLCBUb3Vs

b3Vzc2UsIEZyYW5jZS4mI3hEO01ldGFib21ldHJpeCBMdGQsIEltcGVyaWFsIEluY3ViYXRvciwg

QmVzc2VtZXIgQnVpbGRpbmcsIFByaW5jZSBDb25zb3J0IFJvYWQsIExvbmRvbiwgVUsuJiN4RDtE

aXZpc2lvbiBvZiBDb21wdXRhdGlvbmFsIGFuZCBTeXN0ZW1zIE1lZGljaW5lLCBEZXBhcnRtZW50

IG9mIFN1cmdlcnkgYW5kIENhbmNlciwgSW1wZXJpYWwgQ29sbGVnZSBMb25kb24sIFNvdXRoIEtl

bnNpbmd0b24gQ2FtcHVzLCBMb25kb24sIFVLLiYjeEQ7RmFyciBJbnN0aXR1dGUgb2YgSGVhbHRo

IEluZm9ybWF0aWNzIFJlc2VhcmNoLCBVbml2ZXJzaXR5IENvbGxlZ2UgTG9uZG9uIEluc3RpdHV0

ZSBvZiBIZWFsdGggSW5mb3JtYXRpY3MsIDIyMiBFdXN0b24gUm9hZCwgTG9uZG9uLCBVSy4mI3hE

O01SQyBJbnRlZ3JhdGl2ZSBFcGlkZW1pb2xvZ3kgVW5pdCwgU2Nob29sIG9mIFNvY2lhbCBhbmQg

Q29tbXVuaXR5IE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIEJyaXN0b2wsIE9ha2ZpZWxkIEhvdXNl

LCBPYWtmaWxlZCBHcm92ZSwgQnJpc3RvbCwgVUsuJiN4RDtEZXBhcnRtZW50IG9mIFBlZGlhdHJp

Y3MsIEluc3RpdHV0ZSBmb3IgVHJhbnNsYXRpb25hbCBHZW5vbWljcyBhbmQgUG9wdWxhdGlvbiBT

Y2llbmNlcywgTG9zIEFuZ2VsZXMgQmlvbWVkaWNhbCBSZXNlYXJjaCBJbnN0aXR1dGUgYXQgSGFy

Ym9yLVVDTEEgTWVkaWNhbCBDZW50ZXIsIDEwMDAgVyBDYXJzb24gU3QsIFRvcnJhbmNlLCBDQSwg

VVNBLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgSW5zdGl0dXRlIGZvciBUcmFuc2xhdGlv

bmFsIEdlbm9taWNzIGFuZCBQb3B1bGF0aW9uIFNjaWVuY2VzLCBMb3MgQW5nZWxlcyBCaW9tZWRp

Y2FsIFJlc2VhcmNoIEluc3RpdHV0ZSBhdCBIYXJib3ItVUNMQSBNZWRpY2FsIENlbnRlciwgMTAw

MCBXIENhcnNvbiBTdCwgVG9ycmFuY2UsIENBLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIEVwaWRl

bWlvbG9neSwgRXJhc211cyBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBVbml2ZXJzaXR5IE1l

ZGljYWwgQ2VudGVyIFJvdHRlcmRhbSwgQ0EgUm90dGVyZGFtLCB0aGUgTmV0aGVybGFuZHMuJiN4

RDtEZXBhcnRtZW50IG9mIEVwaWRlbWlvbG9neSwgSHVtYW4gR2VuZXRpY3MsIGFuZCBFbnZpcm9u

bWVudGFsIFNjaWVuY2VzLCBIdW1hbiBHZW5ldGljcyBDZW50ZXIsIFNjaG9vbCBvZiBQdWJsaWMg

SGVhbHRoLCBUaGUgVW5pdmVyc2l0eSBvZiBUZXhhcyBIZWFsdGggU2NpZW5jZSBDZW50ZXIgYXQg

SG91c3RvbiwgMTIwMCBQcmVzc2xlciBTdHJlZXQsIEhvdXN0b24sIFRYLCBVU0EuJiN4RDtEZXBh

cnRtZW50IG9mIEVwaWRlbWlvbG9neSwgSGFydmFyZCBULkguIENoYW4gU2Nob29sIG9mIFB1Ymxp

YyBIZWFsdGgsIDY3NyBIdW50aW5ndG9uIEF2ZW51ZSwgQm9zdG9uLCBNQSwgVVNBLiYjeEQ7TG9u

ZG9uIE5vcnRoIFdlc3QgSGVhbHRoY2FyZSBOSFMgVHJ1c3QsIE5vcnRod2ljayBQYXJrIEhvc3Bp

dGFsLCBXYXRmb3JkIFJkLCBIYXJyb3csIFVLLiYjeEQ7R2VybWFuIFJlc2VhcmNoIENlbnRyZSBm

b3IgRW52aXJvbm1lbnRhbCBIZWFsdGgsIEhlbG1ob2x0eiBaZW50cnVtIE11bmNoZW4sIEluZ29s

c3RhZHRlciBMYW5kc3RyYXNzZSAxLCBEIE5ldWhlcmJlcmcsIEdlcm1hbnkuJiN4RDtNLkQuIENv

bGxlZ2Ugb2YgTWVkaWNpbmUgVW5pdmVyc2l0eSBvZiBWZXJtb250LCBUaGUgUm9iZXJ0IExhcm5l

ciwgR2l2ZW4gTWVkaWNhbCBCbGRnLCBFLTEyNiwgODkgQmVhdW1vbnQgQXZlLCBCdXJsaW5ndG9u

LCBWVCwgVVNBLiYjeEQ7TmF0aW9uYWwgSGVhcnQgJmFtcDsgTHVuZyBJbnN0aXR1dGUsIEZhY3Vs

dHkgb2YgTWVkaWNpbmUsIEltcGVyaWFsIENvbGxlZ2UgTG9uZG9uLCBHdXkgU2NhZGRpbmcgQnVp

bGRpbmcsIERvdmVob3VzZSBTdCwgQ2hlbHNlYSwgTG9uZG9uLCBVSy4mI3hEO0RlcGFydG1lbnQg

b2YgUHJldmVudGl2ZSBNZWRpY2luZSwgTm9ydGh3ZXN0ZXJuIFVuaXZlcnNpdHksIEZlaW5iZXJn

IFNjaG9vbCBvZiBNZWRpY2luZSwgNjgwIE5vcnRoIExha2UgU2hvcmUgRHJpdmUsIFN1aXRlLCAx

NDAwLCBDaGljYWdvLCBJTCwgVVNBLiYjeEQ7SW5zdGl0dXRlIG9mIFNvY2lhbCBhbmQgUHJldmVu

dGl2ZSBNZWRpY2luZSAoSVNQTSksIFVuaXZlcnNpdHkgb2YgQmVybiwgTWl0dGVsc3RyYXNzZSA0

MywgQmVybiwgU3dpdHplcmxhbmQuJiN4RDtTZWN0aW9uIG9uIENhcmRpb3Zhc2N1bGFyIE1lZGlj

aW5lLCBEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBXYWtlIEZvcmVzdCBVbml2ZXJz

aXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgTWVkaWNhbCBDZW50ZXIgQm91bGV2YXJkLCBXaW5zdG9u

LVNhbGVtLCBOQywgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlNlcnVtIG1ldGFi

b2xpYyBzaWduYXR1cmVzIG9mIGNvcm9uYXJ5IGFuZCBjYXJvdGlkIGF0aGVyb3NjbGVyb3NpcyBh

bmQgc3Vic2VxdWVudCBjYXJkaW92YXNjdWxhciBkaXNlYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjI4ODMtMjg5

NjwvcGFnZXM+PHZvbHVtZT40MDwvdm9sdW1lPjxudW1iZXI+MzQ8L251bWJlcj48a2V5d29yZHM+

PGtleXdvcmQ+QXRoZXJvc2NsZXJvc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkNvcm9uYXJ5IGFydGVy

eSBjYWxjaXVtPC9rZXl3b3JkPjxrZXl3b3JkPkVwaWRlbWlvbG9naWNhbCBzdHVkaWVzPC9rZXl3

b3JkPjxrZXl3b3JkPkludGltYS1tZWRpYSB0aGlja25lc3M8L2tleXdvcmQ+PGtleXdvcmQ+TWV0

YWJvbGljIHBoZW5vdHlwaW5nPC9rZXl3b3JkPjxrZXl3b3JkPk1ldGFib2xvbWljczwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2Vw

IDc8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMp

JiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMxMTAyNDA4PC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3B1Ym1lZC8zMTEwMjQwODwvdXJsPjx1cmw+aHR0cHM6Ly93YXRlcm1hcmsuc2ls

dmVyY2hhaXIuY29tL2VoejIzNS5wZGY/dG9rZW49QVFFQ0FIaTIwOEJFNDlPb2FuOWtraFdfRXJj

eTdEbTNaTF85Q2YzcWZLQWM0ODV5c2dBQUFvQXdnZ0o4QmdrcWhraUc5dzBCQndhZ2dnSnRNSUlD

YVFJQkFEQ0NBbUlHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFNRUFTNHdFUVFNNVl3Qy03TWZt

d2V0M2VmY0FnRVFnSUlDTTNPXzBCZUgtc2V1amREZFByQXdObkZoNklLM0VNeV9oRXhRSU40aExH

M3R3LXFOcDduc2dHckJtOUZGMjhxX3NQUTZkREI5XzZZTWZ4a011bm1INDJFRlRxZXl2cFZPQlpr

V1drX0RMb3ltSExnRkdlX1o2Q1dsVGF3SGE3NHVzX2dpTTZaclpYWnZoOTZOYXA4VzNNaTJDM0J0

QlU3Y01BOGhwS3pNX2ZDemROSk5fM0VfMzlWcGItSUMwSzh2NGJ4d2s4b3JKZHlHdmdGNWNZUmNN

M2FpY3dZcDRCQVhzNWJ1d1dWclNDZU1WRXR3TTVSekJfbXNXT2ptSE5NUmZ0WVl6eWx4di1uaTly

VEhjakFURGV0MFFCVnFzclBRbUZMVTlNUnNxY21YZnl4amZ3SnVKaThFVldGbUxqbnhpSWt3bWdS

VTVSN2Z3NDVlV3NvRkoyUnU0aDRWTFRZaWMzMVBtdDNYRFZPN2JVRHowMXZRVjEzMU5xa1c1eUVk

MFdSMk9OLU82UzN0SkVUUG52MVVnejU1bzVOUV9vR3dPbllLYTh3b0ZRemdjUm9tM0JxTkxoTTVt

TlllRXBpSWpkV1RCZGRneWZOV0gtcmVhbFdMNEUzOVJ0Q0R0Z0V4Zi03VXlHUVNiVmpqS1VSYWNz

MUZFMTdzX05oNkh4YzRZdVcxSk1kWHAyN3F4T25QYUlpbG1BbXctcnExQ2lDS29uczJ4cXhlSlR4

R1Z2aVhhSXdUWkE3c2MxX3RTcXo2OWdWMTBQYnlnM0tjbm1GeVRmSmNDa3FKeFVlNTFQSW1Udkg3

ZUR6OGhmdjlyQ3FmUmhaY21NTW1WZGNaZmFFX2tVX2s4cmxUMVRTTUdmNW9nUl9qZkxEaFFUTVBa

TVBldkRWYzVja2dmN3l2ejFvT2s4VnppWjhuNHUydDZIeDA1YldQMlQwSTJuR0RVVDcyYWhzMUpt

UmNDNUNzajhtd2dpWXFnc2ZJNjJKYWlMeVY8L3VybD48dXJsPmh0dHBzOi8vYWNhZGVtaWMub3Vw

LmNvbS9ldXJoZWFydGovYXJ0aWNsZS80MC8zNC8yODgzLzU0OTA3MzQ8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVhcnRqL2Vo

ejIzNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Uem91bGFraTwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+

PFJlY051bT40MDc3PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+MTE8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDc3PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNl

czJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkwNjMxMzYiPjQwNzc8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlR6b3VsYWtpLCBJLjwvYXV0aG9yPjxh

dXRob3I+Q2FzdGFnbmUsIFIuPC9hdXRob3I+PGF1dGhvcj5Cb3VsYW5nZSwgQy4gTC48L2F1dGhv

cj48YXV0aG9yPkthcmFtYW4sIEkuPC9hdXRob3I+PGF1dGhvcj5DaGVrbWVuZXZhLCBFLjwvYXV0

aG9yPjxhdXRob3I+RXZhbmdlbG91LCBFLjwvYXV0aG9yPjxhdXRob3I+RWJiZWxzLCBULiBNLiBE

LjwvYXV0aG9yPjxhdXRob3I+S2FsdWFyYWNoY2hpLCBNLiBSLjwvYXV0aG9yPjxhdXRob3I+Q2hh

ZGVhdS1IeWFtLCBNLjwvYXV0aG9yPjxhdXRob3I+TW9zZW4sIEQuPC9hdXRob3I+PGF1dGhvcj5E

ZWhnaGFuLCBBLjwvYXV0aG9yPjxhdXRob3I+TW9heXllcmksIEEuPC9hdXRob3I+PGF1dGhvcj5G

ZXJyZWlyYSwgRC4gTC4gUy48L2F1dGhvcj48YXV0aG9yPkd1bywgWC48L2F1dGhvcj48YXV0aG9y

PlJvdHRlciwgSi4gSS48L2F1dGhvcj48YXV0aG9yPlRheWxvciwgSy4gRC48L2F1dGhvcj48YXV0

aG9yPkthdm91c2ksIE0uPC9hdXRob3I+PGF1dGhvcj5kZSBWcmllcywgUC4gUy48L2F1dGhvcj48

YXV0aG9yPkxlaG5lLCBCLjwvYXV0aG9yPjxhdXRob3I+TG9oLCBNLjwvYXV0aG9yPjxhdXRob3I+

SG9mbWFuLCBBLjwvYXV0aG9yPjxhdXRob3I+TmljaG9sc29uLCBKLiBLLjwvYXV0aG9yPjxhdXRo

b3I+Q2hhbWJlcnMsIEouPC9hdXRob3I+PGF1dGhvcj5HaWVnZXIsIEMuPC9hdXRob3I+PGF1dGhv

cj5Ib2xtZXMsIEUuPC9hdXRob3I+PGF1dGhvcj5UcmFjeSwgUi48L2F1dGhvcj48YXV0aG9yPktv

b25lciwgSi48L2F1dGhvcj48YXV0aG9yPkdyZWVubGFuZCwgUC48L2F1dGhvcj48YXV0aG9yPkZy

YW5jbywgTy4gSC48L2F1dGhvcj48YXV0aG9yPkhlcnJpbmd0b24sIEQuPC9hdXRob3I+PGF1dGhv

cj5MaW5kb24sIEouIEMuPC9hdXRob3I+PGF1dGhvcj5FbGxpb3R0LCBQLjwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgRXBpZGVtaW9s

b2d5IGFuZCBCaW9zdGF0aXN0aWNzLCBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCwgSW1wZXJpYWwg

Q29sbGVnZSBMb25kb24sIE5vcmZvbGsgUGxhY2UsIExvbmRvbiwgVUsuJiN4RDtNUkMtUEhFIENl

bnRyZSBmb3IgRW52aXJvbm1lbnQgYW5kIEhlYWx0aCwgU2Nob29sIG9mIFB1YmxpYyBIZWFsdGgs

IEltcGVyaWFsIENvbGxlZ2UgTG9uZG9uLCBOb3Jmb2xrIFBsYWNlLCBMb25kb24sIFVLLiYjeEQ7

RGVwYXJ0bWVudCBvZiBIeWdpZW5lIGFuZCBFcGlkZW1pb2xvZ3ksIFVuaXZlcnNpdHkgb2YgSW9h

bm5pbmEgTWVkaWNhbCBTY2hvb2wsIFVuaXZlcnNpdHkgQ2FtcHVzIFJvYWQgNDU1IDAwLCBJb2Fu

bmluYSwgR3JlZWNlLiYjeEQ7RGVtZW50aWEgUmVzZWFyY2ggSW5zdGl0dXRlLCBJbXBlcmlhbCBD

b2xsZWdlIExvbmRvbiwgTm9yZm9sayBQbGFjZSwgTG9uZG9uLCBVSy4mI3hEO0xFQVNQLCBVTVIg

MTAyNywgSW5zZXJtLVVuaXZlcnNpdGUgVG91bG91c3NlIElJSSBQYXVsIFNhYmF0aWVyLCBUb3Vs

b3Vzc2UsIEZyYW5jZS4mI3hEO01ldGFib21ldHJpeCBMdGQsIEltcGVyaWFsIEluY3ViYXRvciwg

QmVzc2VtZXIgQnVpbGRpbmcsIFByaW5jZSBDb25zb3J0IFJvYWQsIExvbmRvbiwgVUsuJiN4RDtE

aXZpc2lvbiBvZiBDb21wdXRhdGlvbmFsIGFuZCBTeXN0ZW1zIE1lZGljaW5lLCBEZXBhcnRtZW50

IG9mIFN1cmdlcnkgYW5kIENhbmNlciwgSW1wZXJpYWwgQ29sbGVnZSBMb25kb24sIFNvdXRoIEtl

bnNpbmd0b24gQ2FtcHVzLCBMb25kb24sIFVLLiYjeEQ7RmFyciBJbnN0aXR1dGUgb2YgSGVhbHRo

IEluZm9ybWF0aWNzIFJlc2VhcmNoLCBVbml2ZXJzaXR5IENvbGxlZ2UgTG9uZG9uIEluc3RpdHV0

ZSBvZiBIZWFsdGggSW5mb3JtYXRpY3MsIDIyMiBFdXN0b24gUm9hZCwgTG9uZG9uLCBVSy4mI3hE

O01SQyBJbnRlZ3JhdGl2ZSBFcGlkZW1pb2xvZ3kgVW5pdCwgU2Nob29sIG9mIFNvY2lhbCBhbmQg

Q29tbXVuaXR5IE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIEJyaXN0b2wsIE9ha2ZpZWxkIEhvdXNl

LCBPYWtmaWxlZCBHcm92ZSwgQnJpc3RvbCwgVUsuJiN4RDtEZXBhcnRtZW50IG9mIFBlZGlhdHJp

Y3MsIEluc3RpdHV0ZSBmb3IgVHJhbnNsYXRpb25hbCBHZW5vbWljcyBhbmQgUG9wdWxhdGlvbiBT

Y2llbmNlcywgTG9zIEFuZ2VsZXMgQmlvbWVkaWNhbCBSZXNlYXJjaCBJbnN0aXR1dGUgYXQgSGFy

Ym9yLVVDTEEgTWVkaWNhbCBDZW50ZXIsIDEwMDAgVyBDYXJzb24gU3QsIFRvcnJhbmNlLCBDQSwg

VVNBLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgSW5zdGl0dXRlIGZvciBUcmFuc2xhdGlv

bmFsIEdlbm9taWNzIGFuZCBQb3B1bGF0aW9uIFNjaWVuY2VzLCBMb3MgQW5nZWxlcyBCaW9tZWRp

Y2FsIFJlc2VhcmNoIEluc3RpdHV0ZSBhdCBIYXJib3ItVUNMQSBNZWRpY2FsIENlbnRlciwgMTAw

MCBXIENhcnNvbiBTdCwgVG9ycmFuY2UsIENBLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIEVwaWRl

bWlvbG9neSwgRXJhc211cyBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBVbml2ZXJzaXR5IE1l

ZGljYWwgQ2VudGVyIFJvdHRlcmRhbSwgQ0EgUm90dGVyZGFtLCB0aGUgTmV0aGVybGFuZHMuJiN4

RDtEZXBhcnRtZW50IG9mIEVwaWRlbWlvbG9neSwgSHVtYW4gR2VuZXRpY3MsIGFuZCBFbnZpcm9u

bWVudGFsIFNjaWVuY2VzLCBIdW1hbiBHZW5ldGljcyBDZW50ZXIsIFNjaG9vbCBvZiBQdWJsaWMg

SGVhbHRoLCBUaGUgVW5pdmVyc2l0eSBvZiBUZXhhcyBIZWFsdGggU2NpZW5jZSBDZW50ZXIgYXQg

SG91c3RvbiwgMTIwMCBQcmVzc2xlciBTdHJlZXQsIEhvdXN0b24sIFRYLCBVU0EuJiN4RDtEZXBh

cnRtZW50IG9mIEVwaWRlbWlvbG9neSwgSGFydmFyZCBULkguIENoYW4gU2Nob29sIG9mIFB1Ymxp

YyBIZWFsdGgsIDY3NyBIdW50aW5ndG9uIEF2ZW51ZSwgQm9zdG9uLCBNQSwgVVNBLiYjeEQ7TG9u

ZG9uIE5vcnRoIFdlc3QgSGVhbHRoY2FyZSBOSFMgVHJ1c3QsIE5vcnRod2ljayBQYXJrIEhvc3Bp

dGFsLCBXYXRmb3JkIFJkLCBIYXJyb3csIFVLLiYjeEQ7R2VybWFuIFJlc2VhcmNoIENlbnRyZSBm

b3IgRW52aXJvbm1lbnRhbCBIZWFsdGgsIEhlbG1ob2x0eiBaZW50cnVtIE11bmNoZW4sIEluZ29s

c3RhZHRlciBMYW5kc3RyYXNzZSAxLCBEIE5ldWhlcmJlcmcsIEdlcm1hbnkuJiN4RDtNLkQuIENv

bGxlZ2Ugb2YgTWVkaWNpbmUgVW5pdmVyc2l0eSBvZiBWZXJtb250LCBUaGUgUm9iZXJ0IExhcm5l

ciwgR2l2ZW4gTWVkaWNhbCBCbGRnLCBFLTEyNiwgODkgQmVhdW1vbnQgQXZlLCBCdXJsaW5ndG9u

LCBWVCwgVVNBLiYjeEQ7TmF0aW9uYWwgSGVhcnQgJmFtcDsgTHVuZyBJbnN0aXR1dGUsIEZhY3Vs

dHkgb2YgTWVkaWNpbmUsIEltcGVyaWFsIENvbGxlZ2UgTG9uZG9uLCBHdXkgU2NhZGRpbmcgQnVp

bGRpbmcsIERvdmVob3VzZSBTdCwgQ2hlbHNlYSwgTG9uZG9uLCBVSy4mI3hEO0RlcGFydG1lbnQg

b2YgUHJldmVudGl2ZSBNZWRpY2luZSwgTm9ydGh3ZXN0ZXJuIFVuaXZlcnNpdHksIEZlaW5iZXJn

IFNjaG9vbCBvZiBNZWRpY2luZSwgNjgwIE5vcnRoIExha2UgU2hvcmUgRHJpdmUsIFN1aXRlLCAx

NDAwLCBDaGljYWdvLCBJTCwgVVNBLiYjeEQ7SW5zdGl0dXRlIG9mIFNvY2lhbCBhbmQgUHJldmVu

dGl2ZSBNZWRpY2luZSAoSVNQTSksIFVuaXZlcnNpdHkgb2YgQmVybiwgTWl0dGVsc3RyYXNzZSA0

MywgQmVybiwgU3dpdHplcmxhbmQuJiN4RDtTZWN0aW9uIG9uIENhcmRpb3Zhc2N1bGFyIE1lZGlj

aW5lLCBEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBXYWtlIEZvcmVzdCBVbml2ZXJz

aXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgTWVkaWNhbCBDZW50ZXIgQm91bGV2YXJkLCBXaW5zdG9u

LVNhbGVtLCBOQywgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlNlcnVtIG1ldGFi

b2xpYyBzaWduYXR1cmVzIG9mIGNvcm9uYXJ5IGFuZCBjYXJvdGlkIGF0aGVyb3NjbGVyb3NpcyBh

bmQgc3Vic2VxdWVudCBjYXJkaW92YXNjdWxhciBkaXNlYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjI4ODMtMjg5

NjwvcGFnZXM+PHZvbHVtZT40MDwvdm9sdW1lPjxudW1iZXI+MzQ8L251bWJlcj48a2V5d29yZHM+

PGtleXdvcmQ+QXRoZXJvc2NsZXJvc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkNvcm9uYXJ5IGFydGVy

eSBjYWxjaXVtPC9rZXl3b3JkPjxrZXl3b3JkPkVwaWRlbWlvbG9naWNhbCBzdHVkaWVzPC9rZXl3

b3JkPjxrZXl3b3JkPkludGltYS1tZWRpYSB0aGlja25lc3M8L2tleXdvcmQ+PGtleXdvcmQ+TWV0

YWJvbGljIHBoZW5vdHlwaW5nPC9rZXl3b3JkPjxrZXl3b3JkPk1ldGFib2xvbWljczwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2Vw

IDc8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMp

JiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMxMTAyNDA4PC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3B1Ym1lZC8zMTEwMjQwODwvdXJsPjx1cmw+aHR0cHM6Ly93YXRlcm1hcmsuc2ls

dmVyY2hhaXIuY29tL2VoejIzNS5wZGY/dG9rZW49QVFFQ0FIaTIwOEJFNDlPb2FuOWtraFdfRXJj

eTdEbTNaTF85Q2YzcWZLQWM0ODV5c2dBQUFvQXdnZ0o4QmdrcWhraUc5dzBCQndhZ2dnSnRNSUlD

YVFJQkFEQ0NBbUlHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFNRUFTNHdFUVFNNVl3Qy03TWZt

d2V0M2VmY0FnRVFnSUlDTTNPXzBCZUgtc2V1amREZFByQXdObkZoNklLM0VNeV9oRXhRSU40aExH

M3R3LXFOcDduc2dHckJtOUZGMjhxX3NQUTZkREI5XzZZTWZ4a011bm1INDJFRlRxZXl2cFZPQlpr

V1drX0RMb3ltSExnRkdlX1o2Q1dsVGF3SGE3NHVzX2dpTTZaclpYWnZoOTZOYXA4VzNNaTJDM0J0

QlU3Y01BOGhwS3pNX2ZDemROSk5fM0VfMzlWcGItSUMwSzh2NGJ4d2s4b3JKZHlHdmdGNWNZUmNN

M2FpY3dZcDRCQVhzNWJ1d1dWclNDZU1WRXR3TTVSekJfbXNXT2ptSE5NUmZ0WVl6eWx4di1uaTly

VEhjakFURGV0MFFCVnFzclBRbUZMVTlNUnNxY21YZnl4amZ3SnVKaThFVldGbUxqbnhpSWt3bWdS

VTVSN2Z3NDVlV3NvRkoyUnU0aDRWTFRZaWMzMVBtdDNYRFZPN2JVRHowMXZRVjEzMU5xa1c1eUVk

MFdSMk9OLU82UzN0SkVUUG52MVVnejU1bzVOUV9vR3dPbllLYTh3b0ZRemdjUm9tM0JxTkxoTTVt

TlllRXBpSWpkV1RCZGRneWZOV0gtcmVhbFdMNEUzOVJ0Q0R0Z0V4Zi03VXlHUVNiVmpqS1VSYWNz

MUZFMTdzX05oNkh4YzRZdVcxSk1kWHAyN3F4T25QYUlpbG1BbXctcnExQ2lDS29uczJ4cXhlSlR4

R1Z2aVhhSXdUWkE3c2MxX3RTcXo2OWdWMTBQYnlnM0tjbm1GeVRmSmNDa3FKeFVlNTFQSW1Udkg3

ZUR6OGhmdjlyQ3FmUmhaY21NTW1WZGNaZmFFX2tVX2s4cmxUMVRTTUdmNW9nUl9qZkxEaFFUTVBa

TVBldkRWYzVja2dmN3l2ejFvT2s4VnppWjhuNHUydDZIeDA1YldQMlQwSTJuR0RVVDcyYWhzMUpt

UmNDNUNzajhtd2dpWXFnc2ZJNjJKYWlMeVY8L3VybD48dXJsPmh0dHBzOi8vYWNhZGVtaWMub3Vw

LmNvbS9ldXJoZWFydGovYXJ0aWNsZS80MC8zNC8yODgzLzU0OTA3MzQ8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVhcnRqL2Vo

ejIzNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA 11 They showed that 30 1H NMR (proton nuclear magnetic resonance spectroscopy) measured metabolites were associated with coronary artery calcium and/or carotid intima-media thickness. Metabolites associated with atherosclerosis were largely consistent between the two vascular beds (carotid and coronary arteries) and predominantly tag pathways that overlap with the known cardiovascular risk factors: disturbances in lipid and carbohydrate metabolism, branched chain, and aromatic amino acid metabolism, as well as oxidative stress and inflammatory pathways.Vascular Biomarkers and CV risk Multimodality vascular assessment enables to evaluate the atherosclerotic process and the cardiovascular risk. In a population-based studyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GZXJuYW5kZXotRnJpZXJhPC9BdXRob3I+PFllYXI+MjAx

OTwvWWVhcj48UmVjTnVtPjQwNzA8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1

cGVyc2NyaXB0Ij4xMjwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQw

NzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJm

Zmp4cHphc2VzMnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTA2MTI0NSI+NDA3

MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RmVybmFuZGV6LUZyaWVy

YSwgTC48L2F1dGhvcj48YXV0aG9yPkZ1c3RlciwgVi48L2F1dGhvcj48YXV0aG9yPkxvcGV6LU1l

bGdhciwgQi48L2F1dGhvcj48YXV0aG9yPk9saXZhLCBCLjwvYXV0aG9yPjxhdXRob3I+U2FuY2hl

ei1Hb256YWxleiwgSi48L2F1dGhvcj48YXV0aG9yPk1hY2lhcywgQS48L2F1dGhvcj48YXV0aG9y

PlBlcmV6LUFzZW5qbywgQi48L2F1dGhvcj48YXV0aG9yPlphbXVkaW8sIEQuPC9hdXRob3I+PGF1

dGhvcj5BbG9uc28tRmFydG8sIEouIEMuPC9hdXRob3I+PGF1dGhvcj5Fc3BhbmEsIFMuPC9hdXRo

b3I+PGF1dGhvcj5NZW5kaWd1cmVuLCBKLjwvYXV0aG9yPjxhdXRob3I+QnVlbm8sIEguPC9hdXRo

b3I+PGF1dGhvcj5HYXJjaWEtUnVpeiwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkliYW5leiwgQi48

L2F1dGhvcj48YXV0aG9yPkZlcm5hbmRlei1PcnRpeiwgQS48L2F1dGhvcj48YXV0aG9yPlNhbnos

IEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q2VudHJv

IE5hY2lvbmFsIGRlIEludmVzdGlnYWNpb25lcyBDYXJkaW92YXNjdWxhcmVzIChDTklDKSwgTWFk

cmlkLCBTcGFpbjsgSG9zcGl0YWwgVW5pdmVyc2l0YXJpbyBITSBNb250ZXByaW5jaXBlLUNJRUMs

IE1hZHJpZCwgU3BhaW47IENJQkVSViwgTWFkcmlkLCBTcGFpbjsgVW5pdmVyc2lkYWQgQ0VVIFNh

biBQYWJsbywgTWFkcmlkLCBTcGFpbi4mI3hEO0NlbnRybyBOYWNpb25hbCBkZSBJbnZlc3RpZ2Fj

aW9uZXMgQ2FyZGlvdmFzY3VsYXJlcyAoQ05JQyksIE1hZHJpZCwgU3BhaW47IEljYWhuIFNjaG9v

bCBvZiBNZWRpY2luZSBhdCBNb3VudCBTaW5haSwgTmV3IFlvcmssIE5ldyBZb3JrLiBFbGVjdHJv

bmljIGFkZHJlc3M6IHZmdXN0ZXJAY25pYy5lcy4mI3hEO0NlbnRybyBOYWNpb25hbCBkZSBJbnZl

c3RpZ2FjaW9uZXMgQ2FyZGlvdmFzY3VsYXJlcyAoQ05JQyksIE1hZHJpZCwgU3BhaW47IEhvc3Bp

dGFsIFVuaXZlcnNpdGFyaW8gSE0gTW9udGVwcmluY2lwZS1DSUVDLCBNYWRyaWQsIFNwYWluOyBV

bml2ZXJzaWRhZCBDRVUgU2FuIFBhYmxvLCBNYWRyaWQsIFNwYWluLiYjeEQ7Q2VudHJvIE5hY2lv

bmFsIGRlIEludmVzdGlnYWNpb25lcyBDYXJkaW92YXNjdWxhcmVzIChDTklDKSwgTWFkcmlkLCBT

cGFpbi4mI3hEO0NlbnRybyBOYWNpb25hbCBkZSBJbnZlc3RpZ2FjaW9uZXMgQ2FyZGlvdmFzY3Vs

YXJlcyAoQ05JQyksIE1hZHJpZCwgU3BhaW47IFBoaWxpcHMgSGVhbHRoY2FyZSwgSWJlcmlhLCBT

cGFpbi4mI3hEO0NlbnRybyBOYWNpb25hbCBkZSBJbnZlc3RpZ2FjaW9uZXMgQ2FyZGlvdmFzY3Vs

YXJlcyAoQ05JQyksIE1hZHJpZCwgU3BhaW47IEhvc3BpdGFsIEdlbmVyYWwgVW5pdmVyc2l0YXJp

byBHcmVnb3JpbyBNYXJhbm9uLCBNYWRyaWQsIFNwYWluLiYjeEQ7QmFuY28gZGUgU2FudGFuZGVy

LCBNYWRyaWQsIFNwYWluLiYjeEQ7Q2VudHJvIE5hY2lvbmFsIGRlIEludmVzdGlnYWNpb25lcyBD

YXJkaW92YXNjdWxhcmVzIChDTklDKSwgTWFkcmlkLCBTcGFpbjsgSG9zcGl0YWwgVW5pdmVyc2l0

YXJpbyAxMiBkZSBPY3R1YnJlIGFuZCBJbnN0aXR1dG8gZGUgSW52ZXN0aWdhY2lvbiBTYW5pdGFy

aWEgSG9zcGl0YWwgMTIgZGUgT2N0dWJyZSAoaW1hczEyKSwgTWFkcmlkLCBTcGFpbjsgRmFjdWx0

YWQgZGUgTWVkaWNpbmEsIFVuaXZlcnNpZGFkIENvbXBsdXRlbnNlIGRlIE1hZHJpZCwgTWFkcmlk

LCBTcGFpbi4mI3hEO0NlbnRybyBOYWNpb25hbCBkZSBJbnZlc3RpZ2FjaW9uZXMgQ2FyZGlvdmFz

Y3VsYXJlcyAoQ05JQyksIE1hZHJpZCwgU3BhaW47IENJQkVSViwgTWFkcmlkLCBTcGFpbjsgSG9z

cGl0YWwgVW5pdmVyc2l0YXJpbyBkZSBDYWJ1ZW5lcyBHaWpvbiwgSW5zdGl0dXRvIGRlIEludmVz

dGlnYWNpb24gU2FuaXRhcmlhIGRlbCBQcmluY2lwYWRvIGRlIEFzdHVyaWFzLCBPdmllZG8sIFNw

YWluLiYjeEQ7Q2VudHJvIE5hY2lvbmFsIGRlIEludmVzdGlnYWNpb25lcyBDYXJkaW92YXNjdWxh

cmVzIChDTklDKSwgTWFkcmlkLCBTcGFpbjsgQ0lCRVJWLCBNYWRyaWQsIFNwYWluOyBJSVMtRnVu

ZGFjaW9uIEppbWVuZXogRGlheiBVbml2ZXJzaXR5IEhvc3BpdGFsLCBNYWRyaWQsIFNwYWluLiYj

eEQ7Q2VudHJvIE5hY2lvbmFsIGRlIEludmVzdGlnYWNpb25lcyBDYXJkaW92YXNjdWxhcmVzIChD

TklDKSwgTWFkcmlkLCBTcGFpbjsgQ0lCRVJWLCBNYWRyaWQsIFNwYWluOyBIb3NwaXRhbCBDbGlu

aWNvIFNhbiBDYXJsb3MsIFVuaXZlcnNpZGFkIENvbXBsdXRlbnNlLCBJZElTU0MsIE1hZHJpZCwg

U3BhaW4uJiN4RDtDZW50cm8gTmFjaW9uYWwgZGUgSW52ZXN0aWdhY2lvbmVzIENhcmRpb3Zhc2N1

bGFyZXMgKENOSUMpLCBNYWRyaWQsIFNwYWluOyBJY2FobiBTY2hvb2wgb2YgTWVkaWNpbmUgYXQg

TW91bnQgU2luYWksIE5ldyBZb3JrLCBOZXcgWW9yay48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0

aXRsZT5WYXNjdWxhciBJbmZsYW1tYXRpb24gaW4gU3ViY2xpbmljYWwgQXRoZXJvc2NsZXJvc2lz

IERldGVjdGVkIGJ5IEh5YnJpZCBQRVQvTVJJPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQW0g

Q29sbCBDYXJkaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjEzNzEtMTM4Mjwv

cGFnZXM+PHZvbHVtZT43Mzwvdm9sdW1lPjxudW1iZXI+MTI8L251bWJlcj48a2V5d29yZHM+PGtl

eXdvcmQ+KDE4KWYtZmRnIHBldC9tcmk8L2tleXdvcmQ+PGtleXdvcmQ+YXJ0ZXJpYWwgaW5mbGFt

bWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPnBsYXF1ZSBpbmZsYW1tYXRpb248L2tleXdvcmQ+PGtl

eXdvcmQ+c3ViY2xpbmljYWwgYXRoZXJvc2NsZXJvc2lzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHIgMjwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjE1NTgtMzU5NyAoRWxlY3Ryb25pYykmI3hEOzA3MzUtMTA5NyAo

TGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MzA5MjI0Njg8L2FjY2Vzc2lvbi1udW0+PHVy

bHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVk

LzMwOTIyNDY4PC91cmw+PHVybD5odHRwczovL3d3dy5zY2llbmNlZGlyZWN0LmNvbS9zY2llbmNl

L2FydGljbGUvcGlpL1MwNzM1MTA5NzE5MzA0MTI3P3ZpYSUzRGlodWI8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5qYWNjLjIwMTgu

MTIuMDc1PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3Rl

Pn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GZXJuYW5kZXotRnJpZXJhPC9BdXRob3I+PFllYXI+MjAx

OTwvWWVhcj48UmVjTnVtPjQwNzA8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1

cGVyc2NyaXB0Ij4xMjwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQw

NzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJm

Zmp4cHphc2VzMnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTA2MTI0NSI+NDA3

MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RmVybmFuZGV6LUZyaWVy

YSwgTC48L2F1dGhvcj48YXV0aG9yPkZ1c3RlciwgVi48L2F1dGhvcj48YXV0aG9yPkxvcGV6LU1l

bGdhciwgQi48L2F1dGhvcj48YXV0aG9yPk9saXZhLCBCLjwvYXV0aG9yPjxhdXRob3I+U2FuY2hl

ei1Hb256YWxleiwgSi48L2F1dGhvcj48YXV0aG9yPk1hY2lhcywgQS48L2F1dGhvcj48YXV0aG9y

PlBlcmV6LUFzZW5qbywgQi48L2F1dGhvcj48YXV0aG9yPlphbXVkaW8sIEQuPC9hdXRob3I+PGF1

dGhvcj5BbG9uc28tRmFydG8sIEouIEMuPC9hdXRob3I+PGF1dGhvcj5Fc3BhbmEsIFMuPC9hdXRo

b3I+PGF1dGhvcj5NZW5kaWd1cmVuLCBKLjwvYXV0aG9yPjxhdXRob3I+QnVlbm8sIEguPC9hdXRo

b3I+PGF1dGhvcj5HYXJjaWEtUnVpeiwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkliYW5leiwgQi48

L2F1dGhvcj48YXV0aG9yPkZlcm5hbmRlei1PcnRpeiwgQS48L2F1dGhvcj48YXV0aG9yPlNhbnos

IEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q2VudHJv

IE5hY2lvbmFsIGRlIEludmVzdGlnYWNpb25lcyBDYXJkaW92YXNjdWxhcmVzIChDTklDKSwgTWFk

cmlkLCBTcGFpbjsgSG9zcGl0YWwgVW5pdmVyc2l0YXJpbyBITSBNb250ZXByaW5jaXBlLUNJRUMs

IE1hZHJpZCwgU3BhaW47IENJQkVSViwgTWFkcmlkLCBTcGFpbjsgVW5pdmVyc2lkYWQgQ0VVIFNh

biBQYWJsbywgTWFkcmlkLCBTcGFpbi4mI3hEO0NlbnRybyBOYWNpb25hbCBkZSBJbnZlc3RpZ2Fj

aW9uZXMgQ2FyZGlvdmFzY3VsYXJlcyAoQ05JQyksIE1hZHJpZCwgU3BhaW47IEljYWhuIFNjaG9v

bCBvZiBNZWRpY2luZSBhdCBNb3VudCBTaW5haSwgTmV3IFlvcmssIE5ldyBZb3JrLiBFbGVjdHJv

bmljIGFkZHJlc3M6IHZmdXN0ZXJAY25pYy5lcy4mI3hEO0NlbnRybyBOYWNpb25hbCBkZSBJbnZl

c3RpZ2FjaW9uZXMgQ2FyZGlvdmFzY3VsYXJlcyAoQ05JQyksIE1hZHJpZCwgU3BhaW47IEhvc3Bp

dGFsIFVuaXZlcnNpdGFyaW8gSE0gTW9udGVwcmluY2lwZS1DSUVDLCBNYWRyaWQsIFNwYWluOyBV

bml2ZXJzaWRhZCBDRVUgU2FuIFBhYmxvLCBNYWRyaWQsIFNwYWluLiYjeEQ7Q2VudHJvIE5hY2lv

bmFsIGRlIEludmVzdGlnYWNpb25lcyBDYXJkaW92YXNjdWxhcmVzIChDTklDKSwgTWFkcmlkLCBT

cGFpbi4mI3hEO0NlbnRybyBOYWNpb25hbCBkZSBJbnZlc3RpZ2FjaW9uZXMgQ2FyZGlvdmFzY3Vs

YXJlcyAoQ05JQyksIE1hZHJpZCwgU3BhaW47IFBoaWxpcHMgSGVhbHRoY2FyZSwgSWJlcmlhLCBT

cGFpbi4mI3hEO0NlbnRybyBOYWNpb25hbCBkZSBJbnZlc3RpZ2FjaW9uZXMgQ2FyZGlvdmFzY3Vs

YXJlcyAoQ05JQyksIE1hZHJpZCwgU3BhaW47IEhvc3BpdGFsIEdlbmVyYWwgVW5pdmVyc2l0YXJp

byBHcmVnb3JpbyBNYXJhbm9uLCBNYWRyaWQsIFNwYWluLiYjeEQ7QmFuY28gZGUgU2FudGFuZGVy

LCBNYWRyaWQsIFNwYWluLiYjeEQ7Q2VudHJvIE5hY2lvbmFsIGRlIEludmVzdGlnYWNpb25lcyBD

YXJkaW92YXNjdWxhcmVzIChDTklDKSwgTWFkcmlkLCBTcGFpbjsgSG9zcGl0YWwgVW5pdmVyc2l0

YXJpbyAxMiBkZSBPY3R1YnJlIGFuZCBJbnN0aXR1dG8gZGUgSW52ZXN0aWdhY2lvbiBTYW5pdGFy

aWEgSG9zcGl0YWwgMTIgZGUgT2N0dWJyZSAoaW1hczEyKSwgTWFkcmlkLCBTcGFpbjsgRmFjdWx0

YWQgZGUgTWVkaWNpbmEsIFVuaXZlcnNpZGFkIENvbXBsdXRlbnNlIGRlIE1hZHJpZCwgTWFkcmlk

LCBTcGFpbi4mI3hEO0NlbnRybyBOYWNpb25hbCBkZSBJbnZlc3RpZ2FjaW9uZXMgQ2FyZGlvdmFz

Y3VsYXJlcyAoQ05JQyksIE1hZHJpZCwgU3BhaW47IENJQkVSViwgTWFkcmlkLCBTcGFpbjsgSG9z

cGl0YWwgVW5pdmVyc2l0YXJpbyBkZSBDYWJ1ZW5lcyBHaWpvbiwgSW5zdGl0dXRvIGRlIEludmVz

dGlnYWNpb24gU2FuaXRhcmlhIGRlbCBQcmluY2lwYWRvIGRlIEFzdHVyaWFzLCBPdmllZG8sIFNw

YWluLiYjeEQ7Q2VudHJvIE5hY2lvbmFsIGRlIEludmVzdGlnYWNpb25lcyBDYXJkaW92YXNjdWxh

cmVzIChDTklDKSwgTWFkcmlkLCBTcGFpbjsgQ0lCRVJWLCBNYWRyaWQsIFNwYWluOyBJSVMtRnVu

ZGFjaW9uIEppbWVuZXogRGlheiBVbml2ZXJzaXR5IEhvc3BpdGFsLCBNYWRyaWQsIFNwYWluLiYj

eEQ7Q2VudHJvIE5hY2lvbmFsIGRlIEludmVzdGlnYWNpb25lcyBDYXJkaW92YXNjdWxhcmVzIChD

TklDKSwgTWFkcmlkLCBTcGFpbjsgQ0lCRVJWLCBNYWRyaWQsIFNwYWluOyBIb3NwaXRhbCBDbGlu

aWNvIFNhbiBDYXJsb3MsIFVuaXZlcnNpZGFkIENvbXBsdXRlbnNlLCBJZElTU0MsIE1hZHJpZCwg

U3BhaW4uJiN4RDtDZW50cm8gTmFjaW9uYWwgZGUgSW52ZXN0aWdhY2lvbmVzIENhcmRpb3Zhc2N1

bGFyZXMgKENOSUMpLCBNYWRyaWQsIFNwYWluOyBJY2FobiBTY2hvb2wgb2YgTWVkaWNpbmUgYXQg

TW91bnQgU2luYWksIE5ldyBZb3JrLCBOZXcgWW9yay48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0

aXRsZT5WYXNjdWxhciBJbmZsYW1tYXRpb24gaW4gU3ViY2xpbmljYWwgQXRoZXJvc2NsZXJvc2lz

IERldGVjdGVkIGJ5IEh5YnJpZCBQRVQvTVJJPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQW0g

Q29sbCBDYXJkaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjEzNzEtMTM4Mjwv

cGFnZXM+PHZvbHVtZT43Mzwvdm9sdW1lPjxudW1iZXI+MTI8L251bWJlcj48a2V5d29yZHM+PGtl

eXdvcmQ+KDE4KWYtZmRnIHBldC9tcmk8L2tleXdvcmQ+PGtleXdvcmQ+YXJ0ZXJpYWwgaW5mbGFt

bWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPnBsYXF1ZSBpbmZsYW1tYXRpb248L2tleXdvcmQ+PGtl

eXdvcmQ+c3ViY2xpbmljYWwgYXRoZXJvc2NsZXJvc2lzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHIgMjwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjE1NTgtMzU5NyAoRWxlY3Ryb25pYykmI3hEOzA3MzUtMTA5NyAo

TGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MzA5MjI0Njg8L2FjY2Vzc2lvbi1udW0+PHVy

bHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVk

LzMwOTIyNDY4PC91cmw+PHVybD5odHRwczovL3d3dy5zY2llbmNlZGlyZWN0LmNvbS9zY2llbmNl

L2FydGljbGUvcGlpL1MwNzM1MTA5NzE5MzA0MTI3P3ZpYSUzRGlodWI8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5qYWNjLjIwMTgu

MTIuMDc1PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3Rl

Pn==

ADDIN EN.CITE.DATA 12 using hybrid 18F-FDG PET and MRI, arterial inflammation was detected in 48% of participants of 40-54 years of age, increasing steadily by the number of risk factors. Aortic, carotid and/or ilio-femoral plaques were present in 90% of cases, but most inflammation was depicted in the plaque-free zones. Inflammation was present only in 11% of plaques, suggesting arterial inflammation in early stage of atherosclerosis process. Atherosclerosis is even identifiable in adolescence, especially in case of unhealthy lifestyle: in an observational studyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGFyYWtpZGE8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFy

PjxSZWNOdW0+NDA2ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3Jp

cHQiPjEzPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA2ODwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDYwOTU3Ij40MDY4PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DaGFyYWtpZGEsIE0uPC9hdXRob3I+

PGF1dGhvcj5HZW9yZ2lvcG91bG9zLCBHLjwvYXV0aG9yPjxhdXRob3I+RGFuZ2FyZHQsIEYuPC9h

dXRob3I+PGF1dGhvcj5DaGllc2EsIFMuIFQuPC9hdXRob3I+PGF1dGhvcj5IdWdoZXMsIEEuIEQu

PC9hdXRob3I+PGF1dGhvcj5SYXBhbGEsIEEuPC9hdXRob3I+PGF1dGhvcj5EYXZleSBTbWl0aCwg

Ry48L2F1dGhvcj48YXV0aG9yPkxhd2xvciwgRC48L2F1dGhvcj48YXV0aG9yPkZpbmVyLCBOLjwv

YXV0aG9yPjxhdXRob3I+RGVhbmZpZWxkLCBKLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPkluc3RpdHV0ZSBvZiBDYXJkaW92YXNjdWxhciBTY2llbmNl

LCBVbml2ZXJzaXR5IENvbGxlZ2UgTG9uZG9uLCBVSy4mI3hEO0RpdmlzaW9uIG9mIEltYWdpbmcg

U2NpZW5jZXMgJmFtcDsgQmlvbWVkaWNhbCBFbmdpbmVlcmluZywgS2luZyZhcG9zO3MgQ29sbGVn

ZSBMb25kb24sIExhbWJldGggV2luZywgU3QgVGhvbWFzJmFwb3M7IEhvc3BpdGFsLCBVSy4mI3hE

O0RlcGFydG1lbnQgb2YgUGFlZGlhdHJpYyBDbGluaWNhbCBQaHlzaW9sb2d5LiBUaGUgUXVlZW4g

U2lsdmlhIENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCwgR290aGVuYnVyZywgU3dlZGVuLiYjeEQ7

TVJDIEludGVncmF0aXZlIEVwaWRlbWlvbG9neSBVbml0IGF0IHRoZSBVbml2ZXJzaXR5IG9mIEJy

aXN0b2wsIEJyaXN0b2wsIFVLLiYjeEQ7UG9wdWxhdGlvbiBIZWFsdGggU2NpZW5jZSwgQnJpc3Rv

bCBNZWRpY2FsIFNjaG9vbCwgVW5pdmVyc2l0eSBvZiBCcmlzdG9sLCBCcmlzdG9sLCBVSy48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FYXJseSB2YXNjdWxhciBkYW1hZ2UgZnJvbSBzbW9r

aW5nIGFuZCBhbGNvaG9sIGluIHRlZW5hZ2UgeWVhcnM6IHRoZSBBTFNQQUMgc3R1ZHk8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48

cGFnZXM+MzQ1LTM1MzwvcGFnZXM+PHZvbHVtZT40MDwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVy

PjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuIDIxPC9kYXRlPjwv

cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02

NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDE2OTU4MTwvYWNjZXNzaW9uLW51

bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w

dWJtZWQvMzAxNjk1ODE8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNv

bS9laHk1MjQucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNm

M3FmS0FjNDg1eXNnQUFBbjB3Z2dKNUJna3Foa2lHOXcwQkJ3YWdnZ0pxTUlJQ1pnSUJBRENDQWw4

R0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTUZzRHU0SmgyeGM0VUJiX3NBZ0VR

Z0lJQ01FNnRBR1JIekVWVHBkQjdhd2M5Zjg3Y2xyU2RyQWllZW9lSTBCQTNiNnZKV2J6Q1Q1THhy

QXV1YTZtTk9sNkE5TnNMNDZreEJIZHViNVpuMHcxTkUxOVZ2X0JSWUJzTFdwYmFfVklZMFVpdTJC

VTFGcXRqNW50RlhlSWZvYnlsTWFBaG8zNDJLWUtjN2dKbGNHV2IzR3RxbXR4anAzc1lUSUVBclFK

aG0zTS1Zejg0V201dXRLLU9Sdi1lbC1nU3MzSG04TXJpNlc1S0JMNzNjaHYxR0ZVRDg3eHdvSENk

Z0lVcm9QNzVzaFBxcWU2RVFWOXBHZ1RmcEJ3VHFvNUY2dFpnSmhtTmdKclRXOW40R25xTmNPMGhZ

eGNUdnYwTm9LVGZSRkNjUnRnbUJzR09sNHFjaFFURHFOVWZ6ekhWUjY2TjlRODVJc2hVYXlYX2JB

Q1Q0c2lPQjd5cW5NSnlsNktCZF9ZdlJFYU91SzNyZEZDMDZHekRFREZSdU1sMFl3Y3J0VGNWWkJ2

T1NHemZ2dFF5MUJwZDRKdGJNME5kU0JzcFRDYVpiTWVhWTY1MTdsZVZTRjJ2SF9vUnZpbkhLZkRl

V0w4TTVlUUZSZjNfSGdmS0hiZTdyOFNKWmthMkYxSlRlNDhiLVYyWl8wd2MzN0FSMkI4aGZCR0x5

and2a1lma3lSOU82REJkWHEwVndPZkUtSm1lTzVobFZERkRfUjB3UlJGVi1MV3Blc1YxSFcwVFAy

MzMwU0pBbENIdHF1Sm11cUozTDNJRXBoLVhEQ1RWREU3TjZrSkM5ZGV2OTdwRTRybjdmZ0tEemJy

WVpZX1FzUGRMS29SZW1LMkZfLWtwUldIbWVrYWFmU0RwelJFUnlnYkZ4NHdYbkd6cjRrMlNocTdH

SXdXN0FmU2VZZGl2UURhX0tISTYtQWNHblo3OXh6OVI4c25tVTdmZmdyNFN0SGFFS2FfS3F6QTA4

Vl9raWVOMmJnalA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNjM0MDEw

MDwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh5

NTI0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGFyYWtpZGE8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFy

PjxSZWNOdW0+NDA2ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3Jp

cHQiPjEzPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA2ODwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDYwOTU3Ij40MDY4PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DaGFyYWtpZGEsIE0uPC9hdXRob3I+

PGF1dGhvcj5HZW9yZ2lvcG91bG9zLCBHLjwvYXV0aG9yPjxhdXRob3I+RGFuZ2FyZHQsIEYuPC9h

dXRob3I+PGF1dGhvcj5DaGllc2EsIFMuIFQuPC9hdXRob3I+PGF1dGhvcj5IdWdoZXMsIEEuIEQu

PC9hdXRob3I+PGF1dGhvcj5SYXBhbGEsIEEuPC9hdXRob3I+PGF1dGhvcj5EYXZleSBTbWl0aCwg

Ry48L2F1dGhvcj48YXV0aG9yPkxhd2xvciwgRC48L2F1dGhvcj48YXV0aG9yPkZpbmVyLCBOLjwv

YXV0aG9yPjxhdXRob3I+RGVhbmZpZWxkLCBKLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPkluc3RpdHV0ZSBvZiBDYXJkaW92YXNjdWxhciBTY2llbmNl

LCBVbml2ZXJzaXR5IENvbGxlZ2UgTG9uZG9uLCBVSy4mI3hEO0RpdmlzaW9uIG9mIEltYWdpbmcg

U2NpZW5jZXMgJmFtcDsgQmlvbWVkaWNhbCBFbmdpbmVlcmluZywgS2luZyZhcG9zO3MgQ29sbGVn

ZSBMb25kb24sIExhbWJldGggV2luZywgU3QgVGhvbWFzJmFwb3M7IEhvc3BpdGFsLCBVSy4mI3hE

O0RlcGFydG1lbnQgb2YgUGFlZGlhdHJpYyBDbGluaWNhbCBQaHlzaW9sb2d5LiBUaGUgUXVlZW4g

U2lsdmlhIENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCwgR290aGVuYnVyZywgU3dlZGVuLiYjeEQ7

TVJDIEludGVncmF0aXZlIEVwaWRlbWlvbG9neSBVbml0IGF0IHRoZSBVbml2ZXJzaXR5IG9mIEJy

aXN0b2wsIEJyaXN0b2wsIFVLLiYjeEQ7UG9wdWxhdGlvbiBIZWFsdGggU2NpZW5jZSwgQnJpc3Rv

bCBNZWRpY2FsIFNjaG9vbCwgVW5pdmVyc2l0eSBvZiBCcmlzdG9sLCBCcmlzdG9sLCBVSy48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FYXJseSB2YXNjdWxhciBkYW1hZ2UgZnJvbSBzbW9r

aW5nIGFuZCBhbGNvaG9sIGluIHRlZW5hZ2UgeWVhcnM6IHRoZSBBTFNQQUMgc3R1ZHk8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48

cGFnZXM+MzQ1LTM1MzwvcGFnZXM+PHZvbHVtZT40MDwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVy

PjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuIDIxPC9kYXRlPjwv

cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02

NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDE2OTU4MTwvYWNjZXNzaW9uLW51

bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w

dWJtZWQvMzAxNjk1ODE8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNv

bS9laHk1MjQucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNm

M3FmS0FjNDg1eXNnQUFBbjB3Z2dKNUJna3Foa2lHOXcwQkJ3YWdnZ0pxTUlJQ1pnSUJBRENDQWw4

R0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTUZzRHU0SmgyeGM0VUJiX3NBZ0VR

Z0lJQ01FNnRBR1JIekVWVHBkQjdhd2M5Zjg3Y2xyU2RyQWllZW9lSTBCQTNiNnZKV2J6Q1Q1THhy

QXV1YTZtTk9sNkE5TnNMNDZreEJIZHViNVpuMHcxTkUxOVZ2X0JSWUJzTFdwYmFfVklZMFVpdTJC

VTFGcXRqNW50RlhlSWZvYnlsTWFBaG8zNDJLWUtjN2dKbGNHV2IzR3RxbXR4anAzc1lUSUVBclFK

aG0zTS1Zejg0V201dXRLLU9Sdi1lbC1nU3MzSG04TXJpNlc1S0JMNzNjaHYxR0ZVRDg3eHdvSENk

Z0lVcm9QNzVzaFBxcWU2RVFWOXBHZ1RmcEJ3VHFvNUY2dFpnSmhtTmdKclRXOW40R25xTmNPMGhZ

eGNUdnYwTm9LVGZSRkNjUnRnbUJzR09sNHFjaFFURHFOVWZ6ekhWUjY2TjlRODVJc2hVYXlYX2JB

Q1Q0c2lPQjd5cW5NSnlsNktCZF9ZdlJFYU91SzNyZEZDMDZHekRFREZSdU1sMFl3Y3J0VGNWWkJ2

T1NHemZ2dFF5MUJwZDRKdGJNME5kU0JzcFRDYVpiTWVhWTY1MTdsZVZTRjJ2SF9vUnZpbkhLZkRl

V0w4TTVlUUZSZjNfSGdmS0hiZTdyOFNKWmthMkYxSlRlNDhiLVYyWl8wd2MzN0FSMkI4aGZCR0x5

and2a1lma3lSOU82REJkWHEwVndPZkUtSm1lTzVobFZERkRfUjB3UlJGVi1MV3Blc1YxSFcwVFAy

MzMwU0pBbENIdHF1Sm11cUozTDNJRXBoLVhEQ1RWREU3TjZrSkM5ZGV2OTdwRTRybjdmZ0tEemJy

WVpZX1FzUGRMS29SZW1LMkZfLWtwUldIbWVrYWFmU0RwelJFUnlnYkZ4NHdYbkd6cjRrMlNocTdH

SXdXN0FmU2VZZGl2UURhX0tISTYtQWNHblo3OXh6OVI4c25tVTdmZmdyNFN0SGFFS2FfS3F6QTA4

Vl9raWVOMmJnalA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNjM0MDEw

MDwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh5

NTI0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 13 including 1,266 young participants aged 13 to 17 years, aortic stiffness, estimated by carotid-femoral pulse-wave velocity (cfPWV) was proportionally increased by the tobacco smoking and alcohol drinking intensities, with a strong potentiation when both were combined (Figure 2). At these ages, smoking and drinking cessation lead to normalization of cfPWV. In the other lifespan tip, vascular markers could be useful to downgrade the estimated risk in elderly people who would have an indication for statins based on risk scores, highly affected by age. In a cohort of 5,805 healthy elderly participants (mean age 69 years), normal (<10) coronary calcium score and no carotid plaque on ultrasound were the most powerful vascular markers to downgrade the predicted CV risk, with respective net reclassification index of 0.29 and 0.14, avoiding unnecessary statin prescription in 34% and 21% of cases. ADDIN EN.CITE <EndNote><Cite><Author>Mortensen</Author><Year>2019</Year><RecNum>4071</RecNum><DisplayText><style face="superscript">14</style></DisplayText><record><rec-number>4071</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1569061380">4071</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mortensen, M. B.</author><author>Fuster, V.</author><author>Muntendam, P.</author><author>Mehran, R.</author><author>Baber, U.</author><author>Sartori, S.</author><author>Falk, E.</author></authors></contributors><auth-address>Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: martin.bodtker.mortensen@clin.au.dk.&#xD;Cardiovascular Institute, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, New York, New York.&#xD;scPharmaceuticals, Lexington, Massachusetts.&#xD;Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.</auth-address><titles><title>Negative Risk Markers for Cardiovascular Events in the Elderly</title><secondary-title>J Am Coll Cardiol</secondary-title></titles><pages>1-11</pages><volume>74</volume><number>1</number><keywords><keyword>elderly</keyword><keyword>galectin-3</keyword><keyword>prevention</keyword><keyword>risk prediction</keyword><keyword>statins</keyword><keyword>subclinical atherosclerosis</keyword></keywords><dates><year>2019</year><pub-dates><date>Jul 9</date></pub-dates></dates><isbn>1558-3597 (Electronic)&#xD;0735-1097 (Linking)</isbn><accession-num>31272534</accession-num><urls><related-urls><url> vascular imaging can efficiently improve patients’ adherence to medical advice for healthy lifestyle. The Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA) open controlled trialPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXNsdW5kPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjQwNjk8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4xNTwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwNjk8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2Vz

MnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTA2MTEyMSI+NDA2OTwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TmFzbHVuZCwgVS48L2F1dGhvcj48YXV0

aG9yPk5nLCBOLjwvYXV0aG9yPjxhdXRob3I+THVuZGdyZW4sIEEuPC9hdXRob3I+PGF1dGhvcj5G

aGFybSwgRS48L2F1dGhvcj48YXV0aG9yPkdyb25sdW5kLCBDLjwvYXV0aG9yPjxhdXRob3I+Sm9o

YW5zc29uLCBILjwvYXV0aG9yPjxhdXRob3I+TGluZGFobCwgQi48L2F1dGhvcj48YXV0aG9yPkxp

bmRhaGwsIEIuPC9hdXRob3I+PGF1dGhvcj5MaW5kdmFsbCwgSy48L2F1dGhvcj48YXV0aG9yPk5p

bHNzb24sIFMuIEsuPC9hdXRob3I+PGF1dGhvcj5Ob3JkaW4sIE0uPC9hdXRob3I+PGF1dGhvcj5O

b3JkaW4sIFMuPC9hdXRob3I+PGF1dGhvcj5OeW1hbiwgRS48L2F1dGhvcj48YXV0aG9yPlJvY2ts

b3YsIEouPC9hdXRob3I+PGF1dGhvcj5WYW5vbGksIEQuPC9hdXRob3I+PGF1dGhvcj5XZWluZWhh

bGwsIEwuPC9hdXRob3I+PGF1dGhvcj5XZW5uYmVyZywgUC48L2F1dGhvcj48YXV0aG9yPldlc3Rl

ciwgUC48L2F1dGhvcj48YXV0aG9yPk5vcmJlcmcsIE0uPC9hdXRob3I+PGF1dGhvcj5WaXB2aXph

IHRyaWFsIGdyb3VwPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl

c3M+SGVhcnQgQ2VudHJlIGFuZCBEZXBhcnRtZW50IG9mIFB1YmxpYyBIZWFsdGggYW5kIENsaW5p

Y2FsIE1lZGljaW5lLCBVbWVhIFVuaXZlcnNpdHksIFVtZWEsIFN3ZWRlbi4gRWxlY3Ryb25pYyBh

ZGRyZXNzOiB1bGYubmFzbHVuZEB1bXUuc2UuJiN4RDtVbml0IG9mIEVwaWRlbWlvbG9neSBhbmQg

R2xvYmFsIEhlYWx0aCwgVW1lYSBVbml2ZXJzaXR5LCBVbWVhLCBTd2VkZW4uJiN4RDtVbml0IG9m

IEZhbWlseSBNZWRpY2luZSwgVW1lYSBVbml2ZXJzaXR5LCBVbWVhLCBTd2VkZW4uJiN4RDtEZXBh

cnRtZW50IG9mIFB1YmxpYyBIZWFsdGggYW5kIENsaW5pY2FsIE1lZGljaW5lLCBEZXBhcnRtZW50

IG9mIFJhZGlhdGlvbiBTY2llbmNlcywgVW1lYSBVbml2ZXJzaXR5LCBVbWVhLCBTd2VkZW4uJiN4

RDtVbml0IG9mIE9jY3VwYXRpb25hbCBhbmQgRW52aXJvbm1lbnRhbCBNZWRpY2luZSwgVW1lYSBV

bml2ZXJzaXR5LCBVbWVhLCBTd2VkZW4uJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljYWwgU2NpZW5j

ZXMgYW5kIFVwcHNhbGEgQ2xpbmljYWwgUmVzZWFyY2ggQ2VudGVyLCBVcHBzYWxhIFVuaXZlcnNp

dHksIFVwcHNhbGEsIFN3ZWRlbi4mI3hEO1VuaXQgb2YgUGh5c2lvbG9naWNhbCBDaGVtaXN0cnks

IERlcGFydG1lbnQgb2YgTWVkaWNhbCBCaW9zY2llbmNlcywgVW1lYSBVbml2ZXJzaXR5LCBVbWVh

LCBTd2VkZW4uJiN4RDtEZXBhcnRtZW50IG9mIFBzeWNob2xvZ3ksIFVtZWEgVW5pdmVyc2l0eSwg

VW1lYSwgU3dlZGVuLiYjeEQ7SGVhcnQgQ2VudHJlIGFuZCBEZXBhcnRtZW50IG9mIFB1YmxpYyBI

ZWFsdGggYW5kIENsaW5pY2FsIE1lZGljaW5lLCBVbWVhIFVuaXZlcnNpdHksIFVtZWEsIFN3ZWRl

bi4mI3hEO1VuaXQgb2YgTWVkaWNpbmUsIFVtZWEgVW5pdmVyc2l0eSwgVW1lYSwgU3dlZGVuLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlZpc3VhbGl6YXRpb24gb2YgYXN5bXB0b21hdGlj

IGF0aGVyb3NjbGVyb3RpYyBkaXNlYXNlIGZvciBvcHRpbXVtIGNhcmRpb3Zhc2N1bGFyIHByZXZl

bnRpb24gKFZJUFZJWkEpOiBhIHByYWdtYXRpYywgb3Blbi1sYWJlbCwgcmFuZG9taXNlZCBjb250

cm9sbGVkIHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkxhbmNldDwvc2Vjb25kYXJ5LXRp

dGxlPjwvdGl0bGVzPjxwYWdlcz4xMzMtMTQyPC9wYWdlcz48dm9sdW1lPjM5Mzwvdm9sdW1lPjxu

dW1iZXI+MTAxNjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtl

eXdvcmQ+QXRoZXJvc2NsZXJvc2lzL2RpYWdub3N0aWMgaW1hZ2luZzwva2V5d29yZD48a2V5d29y

ZD5DYXJkaW92YXNjdWxhciBEaXNlYXNlcy8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3

b3JkPjxrZXl3b3JkPkNhcm90aWQgQXJ0ZXJpZXMvKmRpYWdub3N0aWMgaW1hZ2luZzwva2V5d29y

ZD48a2V5d29yZD5DYXJvdGlkIEludGltYS1NZWRpYSBUaGlja25lc3M8L2tleXdvcmQ+PGtleXdv

cmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxr

ZXl3b3JkPkhlYWx0aCBCZWhhdmlvcjwva2V5d29yZD48a2V5d29yZD5IZWFsdGggUHJvbW90aW9u

L21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkxpcGlk

cy9ibG9vZDwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBB

Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPlByaW1hcnkgUHJldmVudGlvbi8qbWV0aG9kczwva2V5d29y

ZD48a2V5d29yZD5SaXNrIEFzc2Vzc21lbnQvbWV0aG9kczwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuIDEyPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQ3NC01NDdYIChFbGVjdHJvbmljKSYjeEQ7MDE0MC02NzM2

IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDUyMjkxOTwvYWNjZXNzaW9uLW51bT48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJt

ZWQvMzA1MjI5MTk8L3VybD48dXJsPmh0dHBzOi8vcGRmLnNjaWVuY2VkaXJlY3Rhc3NldHMuY29t

LzI3MTA3NC8xLXMyLjAtUzAxNDA2NzM2MTlYMDAwMjEvMS1zMi4wLVMwMTQwNjczNjE4MzI4MTg2

L21haW4ucGRmP1gtQW16LVNlY3VyaXR5LVRva2VuPUFnb0piM0pwWjJsdVgyVmpFQW9hQ1hWekxX

VmhjM1F0TVNKSU1FWUNJUUMzTEFBNWJBRjJZOTVpWGtRbHc1WUE0Nkp2Rk9obzNPQnMxTkNLWEEy

blpnSWhBUGdSZ2QyZUc1ZWxsSlRjTUdGOWw4YXFDbGVzb1BLVzd6YVQ2a1REVjNQdUt1TURDTkwl

MkYlMkYlMkYlMkYlMkYlMkYlMkYlMkYlMkYlMkZ3RVFBaG9NTURVNU1EQXpOVFEyT0RZMUlnejkl

MkJvOWJlNmVXc2JGSW81QXF0d05GaDclMkZSTnBlQkJwZFpuNFB5Qkx6WFclMkZjb1lYJTJGWG1w

cHRsZ0lhVXFoaWcyZUhhQjZOYjBtaU5KNjN2aGJ5Nkd6Zk9telV4Y3R0TGRBS0lNQWVGdzl5b0Y4

dmJtNE4zaGx0NUJ2VU1HOXp0eE1nRjBacEhlYjFKaG9Ha1NaRSUyQm5CMGlqZlpJemtTYnJtbW4w

WGtWOEY0dUF6emw5VEswTFhLdURsS1RxRVh3c3ZFYSUyQkhJSG50T0F5eHE2OVB6JTJGOVFGeHhx

UCUyRkQ0cE9tbmRFcG1MaWhhUFhYblNFWjd1dnJvT1p6eEEwTHM4TUVWMlVlQ2NWRXlLbm96RVQl

MkJXaGk0QnZ6UllRMGNzbjdoYUo1RmptWXZJSzlJSmdJWFVJUXUxS3pkN2c1SWUzclkzRSUyQjlu

ejRubThIU013Y1VQcGp2UDFLZWRkbzhXQXFPWm1ibGFwdTdya1dVblRxTXpNUiUyQm01VXpPJTJG

WXFBbFpVMXc4RVBGRmcydktZbVEyaWZTOHl4YlEzVjRKZUthQSUyRkR4VGdGVGRBJTJCN095TG16

YXhVdHlIdmxTbUtOdHRBbkJCTWlUYVVBV0tMZjRWY0JEbXB5QXZ6Y2xoZGlDJTJGYWtpNWJteUFU

bG42NjNmVExFSVoyR2lHZkZ6QVhLZlV2aTV6UDA5ZDBpWm44THN6Z3pYSG0zY0l3SmhNRkRVd1Yy

bEtqSnBWZEJjaCUyQk5kS2d3QVU0c1o5eHJjanRFd2tCaVAzQTRQZHJUblBaSEZYNW9RTVo1SEdW

RmRSU1k4dGVNTnJSbCUyQndGT3JNQk1wOTl5WlVvNWNEM1oxbkpsOU8zSTFxQ2FEWXE4Yk5ROFFz

RDlXc25LUWF1MVglMkZBUW9DVXdmY3g2WURvT2lCN3FRTmN0eTBZVjdTbnpuTExzWXd4b1kwUDF0

QlZBeEVRZmwwcldlV1ZZNWN6cEtYSkkyYkt6ZSUyRnU4NUhkTVZZTjJRbkxNQkxLSUpRNU15UVpZ

aWJWUm1laE9CUVgzSm42NCUyQk4yRmVDY2h5UDhsVzdsRGl3V0lNUUhFcHZ0bEZSSGlrb004SllH

bGxySXk5SFZlZnZuREdqUk9ScXNEam5HVXdUeFpTblhDbzhNRXpVJTNEJmFtcDtYLUFtei1BbGdv

cml0aG09QVdTNC1ITUFDLVNIQTI1NiZhbXA7WC1BbXotRGF0ZT0yMDE5MDkyMVQxMDE4NTVaJmFt

cDtYLUFtei1TaWduZWRIZWFkZXJzPWhvc3QmYW1wO1gtQW16LUV4cGlyZXM9MzAwJmFtcDtYLUFt

ei1DcmVkZW50aWFsPUFTSUFRM1BIQ1ZUWTRMUkdOWDdMJTJGMjAxOTA5MjElMkZ1cy1lYXN0LTEl

MkZzMyUyRmF3czRfcmVxdWVzdCZhbXA7WC1BbXotU2lnbmF0dXJlPTZmYjE0ZWU4YWUwMDQzZjA3

MjU1NzM1YWQ4YmNjMGQ3NDc5ZWJiZDJmZjVmZDU4YzY2YWE2ZTYyOGUzMjA4MmQmYW1wO2hhc2g9

YWJmNjc1ODI5MTY0MzhhMWYyMDhkMDhiMzEzMjg5MDg1ZmY3Nzk2MWZiNDU2YWQxZmEyNDU1MjRi

OGIzYzFmNSZhbXA7aG9zdD02ODA0MmM5NDM1OTEwMTNhYzJiMjQzMGE4OWIyNzBmNmFmMmM3NmQ4

ZGZkMDg2YTA3MTc2YWZlN2M3NmMyYzYxJmFtcDtwaWk9UzAxNDA2NzM2MTgzMjgxODYmYW1wO3Rp

ZD1zcGRmLWY1ZDhkMGJjLTdiZGYtNGQ5NS1hNzUzLWE0NGRjZTc5MjMwYyZhbXA7c2lkPTEwMGNl

NGZkMzlhZGM2NGEyMTRhYWEzNDdhMzg2ZmRiMTdhYmd4cnFiJmFtcDt0eXBlPWNsaWVudDwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9T

MDE0MC02NzM2KDE4KTMyODE4LTY8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwv

Q2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXNsdW5kPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjQwNjk8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4xNTwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwNjk8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2Vz

MnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTA2MTEyMSI+NDA2OTwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TmFzbHVuZCwgVS48L2F1dGhvcj48YXV0

aG9yPk5nLCBOLjwvYXV0aG9yPjxhdXRob3I+THVuZGdyZW4sIEEuPC9hdXRob3I+PGF1dGhvcj5G

aGFybSwgRS48L2F1dGhvcj48YXV0aG9yPkdyb25sdW5kLCBDLjwvYXV0aG9yPjxhdXRob3I+Sm9o

YW5zc29uLCBILjwvYXV0aG9yPjxhdXRob3I+TGluZGFobCwgQi48L2F1dGhvcj48YXV0aG9yPkxp

bmRhaGwsIEIuPC9hdXRob3I+PGF1dGhvcj5MaW5kdmFsbCwgSy48L2F1dGhvcj48YXV0aG9yPk5p

bHNzb24sIFMuIEsuPC9hdXRob3I+PGF1dGhvcj5Ob3JkaW4sIE0uPC9hdXRob3I+PGF1dGhvcj5O

b3JkaW4sIFMuPC9hdXRob3I+PGF1dGhvcj5OeW1hbiwgRS48L2F1dGhvcj48YXV0aG9yPlJvY2ts

b3YsIEouPC9hdXRob3I+PGF1dGhvcj5WYW5vbGksIEQuPC9hdXRob3I+PGF1dGhvcj5XZWluZWhh

bGwsIEwuPC9hdXRob3I+PGF1dGhvcj5XZW5uYmVyZywgUC48L2F1dGhvcj48YXV0aG9yPldlc3Rl

ciwgUC48L2F1dGhvcj48YXV0aG9yPk5vcmJlcmcsIE0uPC9hdXRob3I+PGF1dGhvcj5WaXB2aXph

IHRyaWFsIGdyb3VwPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl

c3M+SGVhcnQgQ2VudHJlIGFuZCBEZXBhcnRtZW50IG9mIFB1YmxpYyBIZWFsdGggYW5kIENsaW5p

Y2FsIE1lZGljaW5lLCBVbWVhIFVuaXZlcnNpdHksIFVtZWEsIFN3ZWRlbi4gRWxlY3Ryb25pYyBh

ZGRyZXNzOiB1bGYubmFzbHVuZEB1bXUuc2UuJiN4RDtVbml0IG9mIEVwaWRlbWlvbG9neSBhbmQg

R2xvYmFsIEhlYWx0aCwgVW1lYSBVbml2ZXJzaXR5LCBVbWVhLCBTd2VkZW4uJiN4RDtVbml0IG9m

IEZhbWlseSBNZWRpY2luZSwgVW1lYSBVbml2ZXJzaXR5LCBVbWVhLCBTd2VkZW4uJiN4RDtEZXBh

cnRtZW50IG9mIFB1YmxpYyBIZWFsdGggYW5kIENsaW5pY2FsIE1lZGljaW5lLCBEZXBhcnRtZW50

IG9mIFJhZGlhdGlvbiBTY2llbmNlcywgVW1lYSBVbml2ZXJzaXR5LCBVbWVhLCBTd2VkZW4uJiN4

RDtVbml0IG9mIE9jY3VwYXRpb25hbCBhbmQgRW52aXJvbm1lbnRhbCBNZWRpY2luZSwgVW1lYSBV

bml2ZXJzaXR5LCBVbWVhLCBTd2VkZW4uJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljYWwgU2NpZW5j

ZXMgYW5kIFVwcHNhbGEgQ2xpbmljYWwgUmVzZWFyY2ggQ2VudGVyLCBVcHBzYWxhIFVuaXZlcnNp

dHksIFVwcHNhbGEsIFN3ZWRlbi4mI3hEO1VuaXQgb2YgUGh5c2lvbG9naWNhbCBDaGVtaXN0cnks

IERlcGFydG1lbnQgb2YgTWVkaWNhbCBCaW9zY2llbmNlcywgVW1lYSBVbml2ZXJzaXR5LCBVbWVh

LCBTd2VkZW4uJiN4RDtEZXBhcnRtZW50IG9mIFBzeWNob2xvZ3ksIFVtZWEgVW5pdmVyc2l0eSwg

VW1lYSwgU3dlZGVuLiYjeEQ7SGVhcnQgQ2VudHJlIGFuZCBEZXBhcnRtZW50IG9mIFB1YmxpYyBI

ZWFsdGggYW5kIENsaW5pY2FsIE1lZGljaW5lLCBVbWVhIFVuaXZlcnNpdHksIFVtZWEsIFN3ZWRl

bi4mI3hEO1VuaXQgb2YgTWVkaWNpbmUsIFVtZWEgVW5pdmVyc2l0eSwgVW1lYSwgU3dlZGVuLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlZpc3VhbGl6YXRpb24gb2YgYXN5bXB0b21hdGlj

IGF0aGVyb3NjbGVyb3RpYyBkaXNlYXNlIGZvciBvcHRpbXVtIGNhcmRpb3Zhc2N1bGFyIHByZXZl

bnRpb24gKFZJUFZJWkEpOiBhIHByYWdtYXRpYywgb3Blbi1sYWJlbCwgcmFuZG9taXNlZCBjb250

cm9sbGVkIHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkxhbmNldDwvc2Vjb25kYXJ5LXRp

dGxlPjwvdGl0bGVzPjxwYWdlcz4xMzMtMTQyPC9wYWdlcz48dm9sdW1lPjM5Mzwvdm9sdW1lPjxu

dW1iZXI+MTAxNjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtl

eXdvcmQ+QXRoZXJvc2NsZXJvc2lzL2RpYWdub3N0aWMgaW1hZ2luZzwva2V5d29yZD48a2V5d29y

ZD5DYXJkaW92YXNjdWxhciBEaXNlYXNlcy8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3

b3JkPjxrZXl3b3JkPkNhcm90aWQgQXJ0ZXJpZXMvKmRpYWdub3N0aWMgaW1hZ2luZzwva2V5d29y

ZD48a2V5d29yZD5DYXJvdGlkIEludGltYS1NZWRpYSBUaGlja25lc3M8L2tleXdvcmQ+PGtleXdv

cmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxr

ZXl3b3JkPkhlYWx0aCBCZWhhdmlvcjwva2V5d29yZD48a2V5d29yZD5IZWFsdGggUHJvbW90aW9u

L21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkxpcGlk

cy9ibG9vZDwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBB

Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPlByaW1hcnkgUHJldmVudGlvbi8qbWV0aG9kczwva2V5d29y

ZD48a2V5d29yZD5SaXNrIEFzc2Vzc21lbnQvbWV0aG9kczwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuIDEyPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQ3NC01NDdYIChFbGVjdHJvbmljKSYjeEQ7MDE0MC02NzM2

IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDUyMjkxOTwvYWNjZXNzaW9uLW51bT48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJt

ZWQvMzA1MjI5MTk8L3VybD48dXJsPmh0dHBzOi8vcGRmLnNjaWVuY2VkaXJlY3Rhc3NldHMuY29t

LzI3MTA3NC8xLXMyLjAtUzAxNDA2NzM2MTlYMDAwMjEvMS1zMi4wLVMwMTQwNjczNjE4MzI4MTg2

L21haW4ucGRmP1gtQW16LVNlY3VyaXR5LVRva2VuPUFnb0piM0pwWjJsdVgyVmpFQW9hQ1hWekxX

VmhjM1F0TVNKSU1FWUNJUUMzTEFBNWJBRjJZOTVpWGtRbHc1WUE0Nkp2Rk9obzNPQnMxTkNLWEEy

blpnSWhBUGdSZ2QyZUc1ZWxsSlRjTUdGOWw4YXFDbGVzb1BLVzd6YVQ2a1REVjNQdUt1TURDTkwl

MkYlMkYlMkYlMkYlMkYlMkYlMkYlMkYlMkYlMkZ3RVFBaG9NTURVNU1EQXpOVFEyT0RZMUlnejkl

MkJvOWJlNmVXc2JGSW81QXF0d05GaDclMkZSTnBlQkJwZFpuNFB5Qkx6WFclMkZjb1lYJTJGWG1w

cHRsZ0lhVXFoaWcyZUhhQjZOYjBtaU5KNjN2aGJ5Nkd6Zk9telV4Y3R0TGRBS0lNQWVGdzl5b0Y4

dmJtNE4zaGx0NUJ2VU1HOXp0eE1nRjBacEhlYjFKaG9Ha1NaRSUyQm5CMGlqZlpJemtTYnJtbW4w

WGtWOEY0dUF6emw5VEswTFhLdURsS1RxRVh3c3ZFYSUyQkhJSG50T0F5eHE2OVB6JTJGOVFGeHhx

UCUyRkQ0cE9tbmRFcG1MaWhhUFhYblNFWjd1dnJvT1p6eEEwTHM4TUVWMlVlQ2NWRXlLbm96RVQl

MkJXaGk0QnZ6UllRMGNzbjdoYUo1RmptWXZJSzlJSmdJWFVJUXUxS3pkN2c1SWUzclkzRSUyQjlu

ejRubThIU013Y1VQcGp2UDFLZWRkbzhXQXFPWm1ibGFwdTdya1dVblRxTXpNUiUyQm01VXpPJTJG

WXFBbFpVMXc4RVBGRmcydktZbVEyaWZTOHl4YlEzVjRKZUthQSUyRkR4VGdGVGRBJTJCN095TG16

YXhVdHlIdmxTbUtOdHRBbkJCTWlUYVVBV0tMZjRWY0JEbXB5QXZ6Y2xoZGlDJTJGYWtpNWJteUFU

bG42NjNmVExFSVoyR2lHZkZ6QVhLZlV2aTV6UDA5ZDBpWm44THN6Z3pYSG0zY0l3SmhNRkRVd1Yy

bEtqSnBWZEJjaCUyQk5kS2d3QVU0c1o5eHJjanRFd2tCaVAzQTRQZHJUblBaSEZYNW9RTVo1SEdW

RmRSU1k4dGVNTnJSbCUyQndGT3JNQk1wOTl5WlVvNWNEM1oxbkpsOU8zSTFxQ2FEWXE4Yk5ROFFz

RDlXc25LUWF1MVglMkZBUW9DVXdmY3g2WURvT2lCN3FRTmN0eTBZVjdTbnpuTExzWXd4b1kwUDF0

QlZBeEVRZmwwcldlV1ZZNWN6cEtYSkkyYkt6ZSUyRnU4NUhkTVZZTjJRbkxNQkxLSUpRNU15UVpZ

aWJWUm1laE9CUVgzSm42NCUyQk4yRmVDY2h5UDhsVzdsRGl3V0lNUUhFcHZ0bEZSSGlrb004SllH

bGxySXk5SFZlZnZuREdqUk9ScXNEam5HVXdUeFpTblhDbzhNRXpVJTNEJmFtcDtYLUFtei1BbGdv

cml0aG09QVdTNC1ITUFDLVNIQTI1NiZhbXA7WC1BbXotRGF0ZT0yMDE5MDkyMVQxMDE4NTVaJmFt

cDtYLUFtei1TaWduZWRIZWFkZXJzPWhvc3QmYW1wO1gtQW16LUV4cGlyZXM9MzAwJmFtcDtYLUFt

ei1DcmVkZW50aWFsPUFTSUFRM1BIQ1ZUWTRMUkdOWDdMJTJGMjAxOTA5MjElMkZ1cy1lYXN0LTEl

MkZzMyUyRmF3czRfcmVxdWVzdCZhbXA7WC1BbXotU2lnbmF0dXJlPTZmYjE0ZWU4YWUwMDQzZjA3

MjU1NzM1YWQ4YmNjMGQ3NDc5ZWJiZDJmZjVmZDU4YzY2YWE2ZTYyOGUzMjA4MmQmYW1wO2hhc2g9

YWJmNjc1ODI5MTY0MzhhMWYyMDhkMDhiMzEzMjg5MDg1ZmY3Nzk2MWZiNDU2YWQxZmEyNDU1MjRi

OGIzYzFmNSZhbXA7aG9zdD02ODA0MmM5NDM1OTEwMTNhYzJiMjQzMGE4OWIyNzBmNmFmMmM3NmQ4

ZGZkMDg2YTA3MTc2YWZlN2M3NmMyYzYxJmFtcDtwaWk9UzAxNDA2NzM2MTgzMjgxODYmYW1wO3Rp

ZD1zcGRmLWY1ZDhkMGJjLTdiZGYtNGQ5NS1hNzUzLWE0NGRjZTc5MjMwYyZhbXA7c2lkPTEwMGNl

NGZkMzlhZGM2NGEyMTRhYWEzNDdhMzg2ZmRiMTdhYmd4cnFiJmFtcDt0eXBlPWNsaWVudDwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9T

MDE0MC02NzM2KDE4KTMyODE4LTY8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwv

Q2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA 15 randomized 3,532 individuals >40 years attending a screening programme; the control group received regular risk factors screening and guidelines-based management but the results of carotid ultrasound were not disclosed, while the intervention group received, along with their general practitioners, a pictorial presentation of the carotid ultrasound results, including colour-scaled presentations of vascular age based on intima-media thickness, and plaque identification. A nurse called 2-4 weeks later to reassure participants and provide any information needed. The same pictorial information was repeated after 6 months. The baseline Framingham risk score (FRS) and SCORE were respectively at 12.9 and 1.28. At one year, both scores were significantly lower in the intervention group (-1.07, p=0.0017 for FRS and – 0.16, p=0.001 for SCORE), with more striking results in the high-risk group (-2.16 and -2.85, respectively). The persistence of these results and their consequences on CVD events need further evaluation.Lower extremity artery disease (LEAD) LEAD is an increasing public health problem according to the latest global epidemiology report.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tb25nPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQwODI8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4x

Njwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwODI8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2VzMnI3

NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTU5MzMwMiI+NDA4Mjwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U29uZywgUC48L2F1dGhvcj48YXV0aG9yPlJ1

ZGFuLCBELjwvYXV0aG9yPjxhdXRob3I+Wmh1LCBZLjwvYXV0aG9yPjxhdXRob3I+Rm93a2VzLCBG

LiBKLiBJLjwvYXV0aG9yPjxhdXRob3I+UmFoaW1pLCBLLjwvYXV0aG9yPjxhdXRob3I+Rm93a2Vz

LCBGLiBHLiBSLjwvYXV0aG9yPjxhdXRob3I+UnVkYW4sIEkuPC9hdXRob3I+PC9hdXRob3JzPjwv

Y29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q2VudHJlIGZvciBHbG9iYWwgSGVhbHRoIFJlc2Vh

cmNoLCBVc2hlciBJbnN0aXR1dGUgb2YgUG9wdWxhdGlvbiBIZWFsdGggU2NpZW5jZXMgYW5kIElu

Zm9ybWF0aWNzLCBVbml2ZXJzaXR5IG9mIEVkaW5idXJnaCwgRWRpbmJ1cmdoLCBVSy4mI3hEO0Ns

aW5pY2FsIEhvc3BpdGFsIER1YnJhdmEsIFphZ3JlYiwgQ3JvYXRpYS4mI3hEO1RoZSBHZW9yZ2Ug

SW5zdGl0dXRlIGZvciBHbG9iYWwgSGVhbHRoLCBVbml2ZXJzaXR5IG9mIE94Zm9yZCwgT3hmb3Jk

LCBVSy4mI3hEO0J1cm5ldCBJbnN0aXR1dGUsIE1lbGJvdXJuZSwgVklDLCBBdXN0cmFsaWEuJiN4

RDtDZW50cmUgZm9yIEdsb2JhbCBIZWFsdGggUmVzZWFyY2gsIFVzaGVyIEluc3RpdHV0ZSBvZiBQ

b3B1bGF0aW9uIEhlYWx0aCBTY2llbmNlcyBhbmQgSW5mb3JtYXRpY3MsIFVuaXZlcnNpdHkgb2Yg

RWRpbmJ1cmdoLCBFZGluYnVyZ2gsIFVLLiBFbGVjdHJvbmljIGFkZHJlc3M6IGlnb3IucnVkYW5A

ZWQuYWMudWsuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R2xvYmFsLCByZWdpb25hbCwg

YW5kIG5hdGlvbmFsIHByZXZhbGVuY2UgYW5kIHJpc2sgZmFjdG9ycyBmb3IgcGVyaXBoZXJhbCBh

cnRlcnkgZGlzZWFzZSBpbiAyMDE1OiBhbiB1cGRhdGVkIHN5c3RlbWF0aWMgcmV2aWV3IGFuZCBh

bmFseXNpczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5MYW5jZXQgR2xvYiBIZWFsdGg8L3NlY29u

ZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+ZTEwMjAtZTEwMzA8L3BhZ2VzPjx2b2x1bWU+Nzwv

dm9sdW1lPjxudW1iZXI+ODwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0

ZXM+PGRhdGU+QXVnPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MjIxNC0xMDlYIChF

bGVjdHJvbmljKSYjeEQ7MjIxNC0xMDlYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4z

MTMwMzI5MzwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93

d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzEzMDMyOTM8L3VybD48dXJsPmh0dHBzOi8vcGRm

LnNjaWVuY2VkaXJlY3Rhc3NldHMuY29tLzI4Njk3MC8xLXMyLjAtUzIyMTQxMDlYMTlYMDAwOTEv

MS1zMi4wLVMyMjE0MTA5WDE5MzAyNTU0L21haW4ucGRmP1gtQW16LVNlY3VyaXR5LVRva2VuPUFn

b0piM0pwWjJsdVgyVmpFSjclMkYlMkYlMkYlMkYlMkYlMkYlMkYlMkYlMkYlMkZ3RWFDWFZ6TFdW

aGMzUXRNU0pHTUVRQ0lCUmhKU2JYQjZqdHhVUkJiRFJRdGsxQTdGbzU0WmpEUnpMdjdEYmkyeHNj

QWlBODc4clFMUHdXdE44UnhISlJ3ckt4dVk0bnJoaiUyRkpON1VZRUJOMHBGTzFTcmFBd2gzRUFJ

YUREQTFPVEF3TXpVME5qZzJOU0lNdDloVDRtWWk3UWlmRUlkSktyY0RxMWdacldYTXJ0SXU0TTBP

a0EyajNQTFU3VUUyRnFsRXJQV3NXN2k3c2V4aHFnJTJCYmR6OGFiZG1kbiUyRlJzOW1BcFdDQkg2

ZFI5NVZTM2FSb0hPZyUyQnlLYzNERENjJTJCQTFyc3VCcWJQNWlpNW5SeDh5YzNVYzJVZHhXSE01

ckZidjclMkJnWlJTSTFTSiUyQjQwY2hXRXJ5MUtnSXN3a05wMjRyTU5wRlRNUllUalJza2YyNURR

cFBtRzVPSUc2eTdJUndjaFE3MVE2UFJzT0JZb1ptbWc1TzlYdnhwa0RRSk5TUkxybWdrayUyQmxY

Mjh0bGs0cTdodEJSTTQ3UDlGekFjYjV6JTJCVjgySG1XbVRMZDd3NzluTUV5YUZWQSUyQngxMXBB

T2NTU21acUtUcSUyQk14VjBtZ3ZlUnE0bjBYRzNldkVybG90c09JMzZ2cWpXM2tRNVhGbUtrMDFJ

MlFWYmdkMFlYckslMkJHYk9HYUVIamFlOXpybmtub1NZZGZHU2c3RXMzV1MwRTY2WGxDYW9HVmdt

TlUyVmFtbW9mOTF2U0hRZEJtakhEQ3VwQzhyQzI4OWh3T2R4WGlTQWhtZXIzUWtIWHYyVCUyRjRK

Rjd3RVVyc2xRU3BoVHN3NWdMVlZaJTJGbW9MVUZIYURTWjVLV3p2QVhVOWlrN0hEQkxMYzVSd1NX

JTJGdk5vSUhpSCUyQkY5VUNIWHdBdWNNVjdiMCUyQkclMkJvSm9BRmtsUUh6WkJhS05xM3NPZ0JJ

UnRrbDJZYyUyQmlERzg3M2tyZTdFa3V0eGRYVW5rMmlGSDhEQ1dwTGpzQlRxMUFVQUZrcXYlMkJo

Q3NWNzNxRGZuSEY1M1JiY1dtb3UwVmY5UzJXaFJUTXZGMyUyQlJMbFZVWEhRZ2F5WGdlbExiQnBV

WVVORVIzWDlTUkR3cjA1dmhWSXRJNiUyQk05c3lBZjRqTGc4UjJNZFExOSUyRkg4SEdTanclMkJh

bEw0R0hyQ2I0SGQ2VTMyQkZnVXlaMVZlZkkwdU1lcXhoQkNYNHhkaXkyQWNGY2UwS0hwMExVOTBz

Q0t2Y2Zna21najQzdTBKbElOM1ZKc3dtNlhmJTJGelo3dTBUR3czTzRXV29OY29uMkxwamRSZXRM

aHRVYm50YnhhWnFkajlpayUzRCZhbXA7WC1BbXotQWxnb3JpdGhtPUFXUzQtSE1BQy1TSEEyNTYm

YW1wO1gtQW16LURhdGU9MjAxOTA5MjdUMTQwODM5WiZhbXA7WC1BbXotU2lnbmVkSGVhZGVycz1o

b3N0JmFtcDtYLUFtei1FeHBpcmVzPTMwMCZhbXA7WC1BbXotQ3JlZGVudGlhbD1BU0lBUTNQSENW

VFlRTFgyRVgzVyUyRjIwMTkwOTI3JTJGdXMtZWFzdC0xJTJGczMlMkZhd3M0X3JlcXVlc3QmYW1w

O1gtQW16LVNpZ25hdHVyZT1hYjUwMDhjODJlZTFjZmJlYzE0M2JiODliMmU5Mjk0OTQ5OWM0YzM4

MGRhYzFlMWIwYjg5NDgxNTQwZjQzNDhmJmFtcDtoYXNoPTM3YzE0ZjQ0MTA0NmI0NmQ5ZWRhNjU3

YjFmZjQ5ZGQ2YjhhZmQ4NmM1MTljMzI2ZjQxNWY0NTQ0YzRjYTI4NDMmYW1wO2hvc3Q9NjgwNDJj

OTQzNTkxMDEzYWMyYjI0MzBhODliMjcwZjZhZjJjNzZkOGRmZDA4NmEwNzE3NmFmZTdjNzZjMmM2

MSZhbXA7cGlpPVMyMjE0MTA5WDE5MzAyNTU0JmFtcDt0aWQ9c3BkZi1mMTVlNDU0My03ZjdlLTRk

MzctOGU1OC1lYzAyYTdiNDNmYTcmYW1wO3NpZD02YzEzMzFhODFkOWRlMzRlZjcyODkxZS04NDc5

ODViNjRiZjNneHJxYiZhbXA7dHlwZT1jbGllbnQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+

PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvUzIyMTQtMTA5WCgxOSkzMDI1NS00PC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tb25nPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQwODI8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4x

Njwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwODI8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2VzMnI3

NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTU5MzMwMiI+NDA4Mjwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U29uZywgUC48L2F1dGhvcj48YXV0aG9yPlJ1

ZGFuLCBELjwvYXV0aG9yPjxhdXRob3I+Wmh1LCBZLjwvYXV0aG9yPjxhdXRob3I+Rm93a2VzLCBG

LiBKLiBJLjwvYXV0aG9yPjxhdXRob3I+UmFoaW1pLCBLLjwvYXV0aG9yPjxhdXRob3I+Rm93a2Vz

LCBGLiBHLiBSLjwvYXV0aG9yPjxhdXRob3I+UnVkYW4sIEkuPC9hdXRob3I+PC9hdXRob3JzPjwv

Y29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q2VudHJlIGZvciBHbG9iYWwgSGVhbHRoIFJlc2Vh

cmNoLCBVc2hlciBJbnN0aXR1dGUgb2YgUG9wdWxhdGlvbiBIZWFsdGggU2NpZW5jZXMgYW5kIElu

Zm9ybWF0aWNzLCBVbml2ZXJzaXR5IG9mIEVkaW5idXJnaCwgRWRpbmJ1cmdoLCBVSy4mI3hEO0Ns

aW5pY2FsIEhvc3BpdGFsIER1YnJhdmEsIFphZ3JlYiwgQ3JvYXRpYS4mI3hEO1RoZSBHZW9yZ2Ug

SW5zdGl0dXRlIGZvciBHbG9iYWwgSGVhbHRoLCBVbml2ZXJzaXR5IG9mIE94Zm9yZCwgT3hmb3Jk

LCBVSy4mI3hEO0J1cm5ldCBJbnN0aXR1dGUsIE1lbGJvdXJuZSwgVklDLCBBdXN0cmFsaWEuJiN4

RDtDZW50cmUgZm9yIEdsb2JhbCBIZWFsdGggUmVzZWFyY2gsIFVzaGVyIEluc3RpdHV0ZSBvZiBQ

b3B1bGF0aW9uIEhlYWx0aCBTY2llbmNlcyBhbmQgSW5mb3JtYXRpY3MsIFVuaXZlcnNpdHkgb2Yg

RWRpbmJ1cmdoLCBFZGluYnVyZ2gsIFVLLiBFbGVjdHJvbmljIGFkZHJlc3M6IGlnb3IucnVkYW5A

ZWQuYWMudWsuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R2xvYmFsLCByZWdpb25hbCwg

YW5kIG5hdGlvbmFsIHByZXZhbGVuY2UgYW5kIHJpc2sgZmFjdG9ycyBmb3IgcGVyaXBoZXJhbCBh

cnRlcnkgZGlzZWFzZSBpbiAyMDE1OiBhbiB1cGRhdGVkIHN5c3RlbWF0aWMgcmV2aWV3IGFuZCBh

bmFseXNpczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5MYW5jZXQgR2xvYiBIZWFsdGg8L3NlY29u

ZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+ZTEwMjAtZTEwMzA8L3BhZ2VzPjx2b2x1bWU+Nzwv

dm9sdW1lPjxudW1iZXI+ODwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0

ZXM+PGRhdGU+QXVnPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MjIxNC0xMDlYIChF

bGVjdHJvbmljKSYjeEQ7MjIxNC0xMDlYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4z

MTMwMzI5MzwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93

d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzEzMDMyOTM8L3VybD48dXJsPmh0dHBzOi8vcGRm

LnNjaWVuY2VkaXJlY3Rhc3NldHMuY29tLzI4Njk3MC8xLXMyLjAtUzIyMTQxMDlYMTlYMDAwOTEv

MS1zMi4wLVMyMjE0MTA5WDE5MzAyNTU0L21haW4ucGRmP1gtQW16LVNlY3VyaXR5LVRva2VuPUFn

b0piM0pwWjJsdVgyVmpFSjclMkYlMkYlMkYlMkYlMkYlMkYlMkYlMkYlMkYlMkZ3RWFDWFZ6TFdW

aGMzUXRNU0pHTUVRQ0lCUmhKU2JYQjZqdHhVUkJiRFJRdGsxQTdGbzU0WmpEUnpMdjdEYmkyeHNj

QWlBODc4clFMUHdXdE44UnhISlJ3ckt4dVk0bnJoaiUyRkpON1VZRUJOMHBGTzFTcmFBd2gzRUFJ

YUREQTFPVEF3TXpVME5qZzJOU0lNdDloVDRtWWk3UWlmRUlkSktyY0RxMWdacldYTXJ0SXU0TTBP

a0EyajNQTFU3VUUyRnFsRXJQV3NXN2k3c2V4aHFnJTJCYmR6OGFiZG1kbiUyRlJzOW1BcFdDQkg2

ZFI5NVZTM2FSb0hPZyUyQnlLYzNERENjJTJCQTFyc3VCcWJQNWlpNW5SeDh5YzNVYzJVZHhXSE01

ckZidjclMkJnWlJTSTFTSiUyQjQwY2hXRXJ5MUtnSXN3a05wMjRyTU5wRlRNUllUalJza2YyNURR

cFBtRzVPSUc2eTdJUndjaFE3MVE2UFJzT0JZb1ptbWc1TzlYdnhwa0RRSk5TUkxybWdrayUyQmxY

Mjh0bGs0cTdodEJSTTQ3UDlGekFjYjV6JTJCVjgySG1XbVRMZDd3NzluTUV5YUZWQSUyQngxMXBB

T2NTU21acUtUcSUyQk14VjBtZ3ZlUnE0bjBYRzNldkVybG90c09JMzZ2cWpXM2tRNVhGbUtrMDFJ

MlFWYmdkMFlYckslMkJHYk9HYUVIamFlOXpybmtub1NZZGZHU2c3RXMzV1MwRTY2WGxDYW9HVmdt

TlUyVmFtbW9mOTF2U0hRZEJtakhEQ3VwQzhyQzI4OWh3T2R4WGlTQWhtZXIzUWtIWHYyVCUyRjRK

Rjd3RVVyc2xRU3BoVHN3NWdMVlZaJTJGbW9MVUZIYURTWjVLV3p2QVhVOWlrN0hEQkxMYzVSd1NX

JTJGdk5vSUhpSCUyQkY5VUNIWHdBdWNNVjdiMCUyQkclMkJvSm9BRmtsUUh6WkJhS05xM3NPZ0JJ

UnRrbDJZYyUyQmlERzg3M2tyZTdFa3V0eGRYVW5rMmlGSDhEQ1dwTGpzQlRxMUFVQUZrcXYlMkJo

Q3NWNzNxRGZuSEY1M1JiY1dtb3UwVmY5UzJXaFJUTXZGMyUyQlJMbFZVWEhRZ2F5WGdlbExiQnBV

WVVORVIzWDlTUkR3cjA1dmhWSXRJNiUyQk05c3lBZjRqTGc4UjJNZFExOSUyRkg4SEdTanclMkJh

bEw0R0hyQ2I0SGQ2VTMyQkZnVXlaMVZlZkkwdU1lcXhoQkNYNHhkaXkyQWNGY2UwS0hwMExVOTBz

Q0t2Y2Zna21najQzdTBKbElOM1ZKc3dtNlhmJTJGelo3dTBUR3czTzRXV29OY29uMkxwamRSZXRM

aHRVYm50YnhhWnFkajlpayUzRCZhbXA7WC1BbXotQWxnb3JpdGhtPUFXUzQtSE1BQy1TSEEyNTYm

YW1wO1gtQW16LURhdGU9MjAxOTA5MjdUMTQwODM5WiZhbXA7WC1BbXotU2lnbmVkSGVhZGVycz1o

b3N0JmFtcDtYLUFtei1FeHBpcmVzPTMwMCZhbXA7WC1BbXotQ3JlZGVudGlhbD1BU0lBUTNQSENW

VFlRTFgyRVgzVyUyRjIwMTkwOTI3JTJGdXMtZWFzdC0xJTJGczMlMkZhd3M0X3JlcXVlc3QmYW1w

O1gtQW16LVNpZ25hdHVyZT1hYjUwMDhjODJlZTFjZmJlYzE0M2JiODliMmU5Mjk0OTQ5OWM0YzM4

MGRhYzFlMWIwYjg5NDgxNTQwZjQzNDhmJmFtcDtoYXNoPTM3YzE0ZjQ0MTA0NmI0NmQ5ZWRhNjU3

YjFmZjQ5ZGQ2YjhhZmQ4NmM1MTljMzI2ZjQxNWY0NTQ0YzRjYTI4NDMmYW1wO2hvc3Q9NjgwNDJj

OTQzNTkxMDEzYWMyYjI0MzBhODliMjcwZjZhZjJjNzZkOGRmZDA4NmEwNzE3NmFmZTdjNzZjMmM2

MSZhbXA7cGlpPVMyMjE0MTA5WDE5MzAyNTU0JmFtcDt0aWQ9c3BkZi1mMTVlNDU0My03ZjdlLTRk

MzctOGU1OC1lYzAyYTdiNDNmYTcmYW1wO3NpZD02YzEzMzFhODFkOWRlMzRlZjcyODkxZS04NDc5

ODViNjRiZjNneHJxYiZhbXA7dHlwZT1jbGllbnQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+

PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvUzIyMTQtMTA5WCgxOSkzMDI1NS00PC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 16 In 2010, LEAD, defined as ABI ≤0.9, affected 202 million subjects worldwide; this number increased by 22% to 237 million in 2015. Overall prevalence in subjects aged ≥25 years was 5.6% (95%CI: 3.8-8.6), higher in high-income countries than in low- and middle-income countries (LMIC) (7.4% vs. 5.1%), although the vast majority of patients (73%) lived in LMIC. This prevalence was similar between sexes, with higher rates of young (<50 years) patients in LMIC. The association of LEAD with major adverse cardiovascular events (MACE) is well documented, whereas its association with limb events is less clear. In the Veterans Aging Cohort Study, including 125,674 subjects without history of prior amputation, the rate of incident amputation over a median of 9.3 years of follow-up was 1.2 per 1000 person-years.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZWNrbWFuPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjQwODg8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4xNzwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwODg8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2Vz

MnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTY1NTkwMCI+NDA4ODwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmVja21hbiwgSi4gQS48L2F1dGhvcj48

YXV0aG9yPkR1bmNhbiwgTS4gUy48L2F1dGhvcj48YXV0aG9yPkRhbXJhdWVyLCBTLiBNLjwvYXV0

aG9yPjxhdXRob3I+V2VsbHMsIFEuIFMuPC9hdXRob3I+PGF1dGhvcj5CYXJuZXR0LCBKLiBWLjwv

YXV0aG9yPjxhdXRob3I+V2Fzc2VybWFuLCBELiBILjwvYXV0aG9yPjxhdXRob3I+QmVkaW1vLCBS

LiBKLjwvYXV0aG9yPjxhdXRob3I+QnV0dCwgQS4gQS48L2F1dGhvcj48YXV0aG9yPk1hcmNvbmks

IFYuIEMuPC9hdXRob3I+PGF1dGhvcj5TaWNvLCBKLiBKLjwvYXV0aG9yPjxhdXRob3I+VGluZGxl

LCBILiBBLjwvYXV0aG9yPjxhdXRob3I+Qm9uYWNhLCBNLiBQLjwvYXV0aG9yPjxhdXRob3I+QWRh

eSwgQS4gVy48L2F1dGhvcj48YXV0aG9yPkZyZWliZXJnLCBNLiBTLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIENhcmRpb3Zhc2N1bGFy

IE1lZGljaW5lIChKLkEuQi4sIE0uUy5ELiwgUS5TLlcuLCBBLlcuQS4sIE0uUy5GLiksIE5hc2h2

aWxsZSwgVE4uJiN4RDtEZXBhcnRtZW50IG9mIFN1cmdlcnksIFBlcmVsbWFuIFNjaG9vbCBvZiBN

ZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEgKFMuTS5ELiksIFBoaWxhZGVscGhp

YS4mI3hEO0NvcnBvcmFsIE1pY2hhZWwgQ3Jlc2NlbnogVkEgTWVkaWNhbCBDZW50ZXIgKFMuTS5E

LiksIFBoaWxhZGVscGhpYS4mI3hEO0RlcGFydG1lbnQgb2YgUGhhcm1hY29sb2d5IChKLlYuQi4p

LCBOYXNodmlsbGUsIFROLiYjeEQ7VmFuZGVyYmlsdCBVbml2ZXJzaXR5LCBEZXBhcnRtZW50IG9m

IE1vbGVjdWxhciBQaHlzaW9sb2d5IGFuZCBCaW9waHlzaWNzLCBWYW5kZXJiaWx0IFVuaXZlcnNp

dHkgU2Nob29sIG9mIE1lZGljaW5lIChELkguVy4pLCBOYXNodmlsbGUsIFROLiYjeEQ7SW5mZWN0

aW91cyBEaXNlYXNlIFNlY3Rpb24sIFZBIE5vcnRoIFRleGFzIEhlYWx0aCBDZW50ZXIgYW5kIFVu

aXZlcnNpdHkgb2YgVGV4YXMgU291dGh3ZXN0ZXJuIE1lZGljYWwgQ2VudGVyLCBEYWxsYXMgKFIu

Si5CLikuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBXZWlsbCBDb3JuZWxsIE1lZGljYWwg

Q29sbGVnZSwgTmV3IFlvcmssIE5ZIChBLkEuQikuJiN4RDtBdGxhbnRhIFZldGVyYW5zIEFmZmFp

cnMgTWVkaWNhbCBDZW50ZXIgYW5kIEVtb3J5IFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5l

LCBHQSAoVi5DLk0uKS4mI3hEO1ZBIENvbm5lY3RpY3V0IEhlYWx0aGNhcmUgU3lzdGVtLCBXZXN0

IEhhdmVuIChKLkouUy4pLiYjeEQ7RGl2aXNpb24gb2YgR2VuZXJhbCBJbnRlcm5hbCBNZWRpY2lu

ZSBhbmQgUHVibGljIEhlYWx0aCAoSC5BLlQuKSwgTmFzaHZpbGxlLCBUTi4mI3hEO1lhbGUgU2No

b29sIG9mIE1lZGljaW5lLCBEZXBhcnRtZW50cyBvZiBOZXVyb2xvZ3kgYW5kIEludGVybmFsIE1l

ZGljaW5lLCBOZXcgSGF2ZW4sIENULiBHZXJpYXRyaWMgUmVzZWFyY2ggRWR1Y2F0aW9uIGFuZCBD

bGluaWNhbCBDZW50ZXJzLCBWZXRlcmFucyBBZmZhaXJzIFRlbm5lc3NlZSBWYWxsZXkgSGVhbHRo

Y2FyZSBTeXN0ZW0sIE5hc2h2aWxsZSAoSC5BLlQuKS4mI3hEO1VuaXZlcnNpdHkgb2YgQ29sb3Jh

ZG8gU2Nob29sIG9mIE1lZGljaW5lIGFuZCBDb2xvcmFkbyBQcmV2ZW50aW9uIENlbnRlciBDbGlu

aWNhbCBSZXNlYXJjaCwgQXVyb3JhIChNLlAuQi4pLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPk1pY3JvdmFzY3VsYXIgRGlzZWFzZSwgUGVyaXBoZXJhbCBBcnRlcnkgRGlzZWFzZSwgYW5k

IEFtcHV0YXRpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2lyY3VsYXRpb248L3NlY29uZGFy

eS10aXRsZT48L3RpdGxlcz48cGFnZXM+NDQ5LTQ1ODwvcGFnZXM+PHZvbHVtZT4xNDA8L3ZvbHVt

ZT48bnVtYmVyPjY8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+YW1wdXRhdGlvbjwva2V5d29y

ZD48a2V5d29yZD5jYXJkaW92YXNjdWxhciBkaXNlYXNlczwva2V5d29yZD48a2V5d29yZD5wZXJp

cGhlcmFsIGFydGVyeSBkaXNlYXNlPC9rZXl3b3JkPjxrZXl3b3JkPnJpc2sgZmFjdG9yczwva2V5

d29yZD48a2V5d29yZD52ZXRlcmFuczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDY8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRl

cz48aXNibj4xNTI0LTQ1MzkgKEVsZWN0cm9uaWMpJiN4RDswMDA5LTczMjIgKExpbmtpbmcpPC9p

c2JuPjxhY2Nlc3Npb24tbnVtPjMxMjgwNTg5PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVk

LXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMTI4MDU4OTwv

dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM2NjgyNDMxPC9jdXN0b20yPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTYxL0NJUkNVTEFUSU9OQUhBLjExOS4wNDA2NzI8

L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZWNrbWFuPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjQwODg8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4xNzwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwODg8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2Vz

MnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTY1NTkwMCI+NDA4ODwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmVja21hbiwgSi4gQS48L2F1dGhvcj48

YXV0aG9yPkR1bmNhbiwgTS4gUy48L2F1dGhvcj48YXV0aG9yPkRhbXJhdWVyLCBTLiBNLjwvYXV0

aG9yPjxhdXRob3I+V2VsbHMsIFEuIFMuPC9hdXRob3I+PGF1dGhvcj5CYXJuZXR0LCBKLiBWLjwv

YXV0aG9yPjxhdXRob3I+V2Fzc2VybWFuLCBELiBILjwvYXV0aG9yPjxhdXRob3I+QmVkaW1vLCBS

LiBKLjwvYXV0aG9yPjxhdXRob3I+QnV0dCwgQS4gQS48L2F1dGhvcj48YXV0aG9yPk1hcmNvbmks

IFYuIEMuPC9hdXRob3I+PGF1dGhvcj5TaWNvLCBKLiBKLjwvYXV0aG9yPjxhdXRob3I+VGluZGxl

LCBILiBBLjwvYXV0aG9yPjxhdXRob3I+Qm9uYWNhLCBNLiBQLjwvYXV0aG9yPjxhdXRob3I+QWRh

eSwgQS4gVy48L2F1dGhvcj48YXV0aG9yPkZyZWliZXJnLCBNLiBTLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIENhcmRpb3Zhc2N1bGFy

IE1lZGljaW5lIChKLkEuQi4sIE0uUy5ELiwgUS5TLlcuLCBBLlcuQS4sIE0uUy5GLiksIE5hc2h2

aWxsZSwgVE4uJiN4RDtEZXBhcnRtZW50IG9mIFN1cmdlcnksIFBlcmVsbWFuIFNjaG9vbCBvZiBN

ZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEgKFMuTS5ELiksIFBoaWxhZGVscGhp

YS4mI3hEO0NvcnBvcmFsIE1pY2hhZWwgQ3Jlc2NlbnogVkEgTWVkaWNhbCBDZW50ZXIgKFMuTS5E

LiksIFBoaWxhZGVscGhpYS4mI3hEO0RlcGFydG1lbnQgb2YgUGhhcm1hY29sb2d5IChKLlYuQi4p

LCBOYXNodmlsbGUsIFROLiYjeEQ7VmFuZGVyYmlsdCBVbml2ZXJzaXR5LCBEZXBhcnRtZW50IG9m

IE1vbGVjdWxhciBQaHlzaW9sb2d5IGFuZCBCaW9waHlzaWNzLCBWYW5kZXJiaWx0IFVuaXZlcnNp

dHkgU2Nob29sIG9mIE1lZGljaW5lIChELkguVy4pLCBOYXNodmlsbGUsIFROLiYjeEQ7SW5mZWN0

aW91cyBEaXNlYXNlIFNlY3Rpb24sIFZBIE5vcnRoIFRleGFzIEhlYWx0aCBDZW50ZXIgYW5kIFVu

aXZlcnNpdHkgb2YgVGV4YXMgU291dGh3ZXN0ZXJuIE1lZGljYWwgQ2VudGVyLCBEYWxsYXMgKFIu

Si5CLikuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBXZWlsbCBDb3JuZWxsIE1lZGljYWwg

Q29sbGVnZSwgTmV3IFlvcmssIE5ZIChBLkEuQikuJiN4RDtBdGxhbnRhIFZldGVyYW5zIEFmZmFp

cnMgTWVkaWNhbCBDZW50ZXIgYW5kIEVtb3J5IFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5l

LCBHQSAoVi5DLk0uKS4mI3hEO1ZBIENvbm5lY3RpY3V0IEhlYWx0aGNhcmUgU3lzdGVtLCBXZXN0

IEhhdmVuIChKLkouUy4pLiYjeEQ7RGl2aXNpb24gb2YgR2VuZXJhbCBJbnRlcm5hbCBNZWRpY2lu

ZSBhbmQgUHVibGljIEhlYWx0aCAoSC5BLlQuKSwgTmFzaHZpbGxlLCBUTi4mI3hEO1lhbGUgU2No

b29sIG9mIE1lZGljaW5lLCBEZXBhcnRtZW50cyBvZiBOZXVyb2xvZ3kgYW5kIEludGVybmFsIE1l

ZGljaW5lLCBOZXcgSGF2ZW4sIENULiBHZXJpYXRyaWMgUmVzZWFyY2ggRWR1Y2F0aW9uIGFuZCBD

bGluaWNhbCBDZW50ZXJzLCBWZXRlcmFucyBBZmZhaXJzIFRlbm5lc3NlZSBWYWxsZXkgSGVhbHRo

Y2FyZSBTeXN0ZW0sIE5hc2h2aWxsZSAoSC5BLlQuKS4mI3hEO1VuaXZlcnNpdHkgb2YgQ29sb3Jh

ZG8gU2Nob29sIG9mIE1lZGljaW5lIGFuZCBDb2xvcmFkbyBQcmV2ZW50aW9uIENlbnRlciBDbGlu

aWNhbCBSZXNlYXJjaCwgQXVyb3JhIChNLlAuQi4pLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPk1pY3JvdmFzY3VsYXIgRGlzZWFzZSwgUGVyaXBoZXJhbCBBcnRlcnkgRGlzZWFzZSwgYW5k

IEFtcHV0YXRpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2lyY3VsYXRpb248L3NlY29uZGFy

eS10aXRsZT48L3RpdGxlcz48cGFnZXM+NDQ5LTQ1ODwvcGFnZXM+PHZvbHVtZT4xNDA8L3ZvbHVt

ZT48bnVtYmVyPjY8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+YW1wdXRhdGlvbjwva2V5d29y

ZD48a2V5d29yZD5jYXJkaW92YXNjdWxhciBkaXNlYXNlczwva2V5d29yZD48a2V5d29yZD5wZXJp

cGhlcmFsIGFydGVyeSBkaXNlYXNlPC9rZXl3b3JkPjxrZXl3b3JkPnJpc2sgZmFjdG9yczwva2V5

d29yZD48a2V5d29yZD52ZXRlcmFuczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDY8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRl

cz48aXNibj4xNTI0LTQ1MzkgKEVsZWN0cm9uaWMpJiN4RDswMDA5LTczMjIgKExpbmtpbmcpPC9p

c2JuPjxhY2Nlc3Npb24tbnVtPjMxMjgwNTg5PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVk

LXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMTI4MDU4OTwv

dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM2NjgyNDMxPC9jdXN0b20yPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTYxL0NJUkNVTEFUSU9OQUhBLjExOS4wNDA2NzI8

L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA 17 The presence of LEAD conferred a 13.9-fold increase in amputation risk, but microvascular disease (MVD), defined as retino-, neuro- and/or nephropathy, was also associated with a 3.7-fold risk increase, and the combination of LEAD and MVD lead to a 22.7-fold increased risk. Importantly, MVD alone was associated with 15% of all below-the-knee amputations.Among the 13,885 patients with an ABI ≤0.8 or prior lower extremity revascularization (LER) randomized to ticagrelor vs. clopidogrel in the Examining Use of Ticagrelor in Peripheral Artery Disease (EUCLID) trial, the rate of acute limb ischaemia (ALI) requiring hospitalization was 0.8 per 100 patient-years, with no difference between treatment arms.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IZXNzPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQwODM8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4x

ODwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwODM8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2VzMnI3

NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTU5MzQyOCI+NDA4Mzwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SGVzcywgQy4gTi48L2F1dGhvcj48YXV0aG9y

Pkh1YW5nLCBaLjwvYXV0aG9yPjxhdXRob3I+UGF0ZWwsIE0uIFIuPC9hdXRob3I+PGF1dGhvcj5C

YXVtZ2FydG5lciwgSS48L2F1dGhvcj48YXV0aG9yPkJlcmdlciwgSi4gUy48L2F1dGhvcj48YXV0

aG9yPkJsb21zdGVyLCBKLiBJLjwvYXV0aG9yPjxhdXRob3I+Rm93a2VzLCBGLiBHLiBSLjwvYXV0

aG9yPjxhdXRob3I+SGVsZCwgUC48L2F1dGhvcj48YXV0aG9yPkpvbmVzLCBXLiBTLjwvYXV0aG9y

PjxhdXRob3I+S2F0b25hLCBCLjwvYXV0aG9yPjxhdXRob3I+TWFoYWZmZXksIEsuIFcuPC9hdXRo

b3I+PGF1dGhvcj5Ob3JncmVuLCBMLjwvYXV0aG9yPjxhdXRob3I+Um9ja2hvbGQsIEYuIFcuPC9h

dXRob3I+PGF1dGhvcj5IaWF0dCwgVy4gUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBDYXJkaW9sb2d5LCBEZXBhcnRtZW50IG9mIE1l

ZGljaW5lLCBVbml2ZXJzaXR5IG9mIENvbG9yYWRvIFNjaG9vbCBvZiBNZWRpY2luZSBhbmQgQ1BD

IENsaW5pY2FsIFJlc2VhcmNoLCBBdXJvcmEgKEMuTi5ILiwgVy5SLkguKS4mI3hEO0R1a2UgQ2xp

bmljYWwgUmVzZWFyY2ggSW5zdGl0dXRlLCBEdWtlIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGlj

aW5lLCBEdXJoYW0sIE5DIChaLkguLCBNLlIuUC4sIFcuUy5KLiwgRi5XLlIuKS4mI3hEO1N3aXNz

IENhcmRpb3Zhc2N1bGFyIENlbnRlciwgSW5zZWxzcGl0YWwtQmVybiBVbml2ZXJzaXR5IEhvc3Bp

dGFsLCBVbml2ZXJzaXR5IG9mIEJlcm4sIFN3aXR6ZXJsYW5kIChJLkIuKS4mI3hEO0RlcGFydG1l

bnRzIG9mIE1lZGljaW5lIGFuZCBTdXJnZXJ5LCBOZXcgWW9yayBVbml2ZXJzaXR5IFNjaG9vbCBv

ZiBNZWRpY2luZSAoSi5TLkIuKS4mI3hEO1R1cmt1IFVuaXZlcnNpdHkgSG9zcGl0YWwsIEZpbmxh

bmQgKEouSS5CLikuJiN4RDtVc2hlciBJbnN0aXR1dGUgb2YgUG9wdWxhdGlvbiBIZWFsdGggU2Np

ZW5jZXMgYW5kIEluZm9ybWF0aWNzLCBVbml2ZXJzaXR5IG9mIEVkaW5idXJnaCwgVW5pdGVkIEtp

bmdkb20gKEYuRy5SLkYuKS4mI3hEO1VuaXZlcnNpdHkgb2YgR290aGVuYnVyZywgU3dlZGVuIChQ

LkguKS4mI3hEO0FzdHJhWmVuZWNhIEdhaXRoZXJzYnVyZywgTUQgKEIuSy4pLiYjeEQ7U3RhbmZv

cmQgQ2VudGVyIGZvciBDbGluaWNhbCBSZXNlYXJjaCwgU3RhbmZvcmQgVW5pdmVyc2l0eSBTY2hv

b2wgb2YgTWVkaWNpbmUsIENBIChLLlcuTS4pLiYjeEQ7RmFjdWx0eSBvZiBNZWRpY2luZSBhbmQg

SGVhbHRoLCBPcmVicm8gVW5pdmVyc2l0eSwgU3dlZGVuIChMLk4uKS48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5BY3V0ZSBMaW1iIElzY2hlbWlhIGluIFBlcmlwaGVyYWwgQXJ0ZXJ5IERp

c2Vhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2lyY3VsYXRpb248L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+NTU2LTU2NTwvcGFnZXM+PHZvbHVtZT4xNDA8L3ZvbHVtZT48bnVt

YmVyPjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+cGVyaXBoZXJhbCBhcnRlcmlhbCBkaXNl

YXNlPC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCBvdXRjb21lPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWcgMTM8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI0LTQ1MzkgKEVsZWN0cm9uaWMpJiN4RDswMDA5

LTczMjIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMxMjM4NzEzPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8zMTIzODcxMzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+MTAuMTE2MS9DSVJDVUxBVElPTkFIQS4xMTkuMDM5NzczPC9lbGVjdHJvbmlj

LXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IZXNzPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQwODM8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4x

ODwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwODM8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2VzMnI3

NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTU5MzQyOCI+NDA4Mzwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SGVzcywgQy4gTi48L2F1dGhvcj48YXV0aG9y

Pkh1YW5nLCBaLjwvYXV0aG9yPjxhdXRob3I+UGF0ZWwsIE0uIFIuPC9hdXRob3I+PGF1dGhvcj5C

YXVtZ2FydG5lciwgSS48L2F1dGhvcj48YXV0aG9yPkJlcmdlciwgSi4gUy48L2F1dGhvcj48YXV0

aG9yPkJsb21zdGVyLCBKLiBJLjwvYXV0aG9yPjxhdXRob3I+Rm93a2VzLCBGLiBHLiBSLjwvYXV0

aG9yPjxhdXRob3I+SGVsZCwgUC48L2F1dGhvcj48YXV0aG9yPkpvbmVzLCBXLiBTLjwvYXV0aG9y

PjxhdXRob3I+S2F0b25hLCBCLjwvYXV0aG9yPjxhdXRob3I+TWFoYWZmZXksIEsuIFcuPC9hdXRo

b3I+PGF1dGhvcj5Ob3JncmVuLCBMLjwvYXV0aG9yPjxhdXRob3I+Um9ja2hvbGQsIEYuIFcuPC9h

dXRob3I+PGF1dGhvcj5IaWF0dCwgVy4gUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBDYXJkaW9sb2d5LCBEZXBhcnRtZW50IG9mIE1l

ZGljaW5lLCBVbml2ZXJzaXR5IG9mIENvbG9yYWRvIFNjaG9vbCBvZiBNZWRpY2luZSBhbmQgQ1BD

IENsaW5pY2FsIFJlc2VhcmNoLCBBdXJvcmEgKEMuTi5ILiwgVy5SLkguKS4mI3hEO0R1a2UgQ2xp

bmljYWwgUmVzZWFyY2ggSW5zdGl0dXRlLCBEdWtlIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGlj

aW5lLCBEdXJoYW0sIE5DIChaLkguLCBNLlIuUC4sIFcuUy5KLiwgRi5XLlIuKS4mI3hEO1N3aXNz

IENhcmRpb3Zhc2N1bGFyIENlbnRlciwgSW5zZWxzcGl0YWwtQmVybiBVbml2ZXJzaXR5IEhvc3Bp

dGFsLCBVbml2ZXJzaXR5IG9mIEJlcm4sIFN3aXR6ZXJsYW5kIChJLkIuKS4mI3hEO0RlcGFydG1l

bnRzIG9mIE1lZGljaW5lIGFuZCBTdXJnZXJ5LCBOZXcgWW9yayBVbml2ZXJzaXR5IFNjaG9vbCBv

ZiBNZWRpY2luZSAoSi5TLkIuKS4mI3hEO1R1cmt1IFVuaXZlcnNpdHkgSG9zcGl0YWwsIEZpbmxh

bmQgKEouSS5CLikuJiN4RDtVc2hlciBJbnN0aXR1dGUgb2YgUG9wdWxhdGlvbiBIZWFsdGggU2Np

ZW5jZXMgYW5kIEluZm9ybWF0aWNzLCBVbml2ZXJzaXR5IG9mIEVkaW5idXJnaCwgVW5pdGVkIEtp

bmdkb20gKEYuRy5SLkYuKS4mI3hEO1VuaXZlcnNpdHkgb2YgR290aGVuYnVyZywgU3dlZGVuIChQ

LkguKS4mI3hEO0FzdHJhWmVuZWNhIEdhaXRoZXJzYnVyZywgTUQgKEIuSy4pLiYjeEQ7U3RhbmZv

cmQgQ2VudGVyIGZvciBDbGluaWNhbCBSZXNlYXJjaCwgU3RhbmZvcmQgVW5pdmVyc2l0eSBTY2hv

b2wgb2YgTWVkaWNpbmUsIENBIChLLlcuTS4pLiYjeEQ7RmFjdWx0eSBvZiBNZWRpY2luZSBhbmQg

SGVhbHRoLCBPcmVicm8gVW5pdmVyc2l0eSwgU3dlZGVuIChMLk4uKS48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5BY3V0ZSBMaW1iIElzY2hlbWlhIGluIFBlcmlwaGVyYWwgQXJ0ZXJ5IERp

c2Vhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2lyY3VsYXRpb248L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+NTU2LTU2NTwvcGFnZXM+PHZvbHVtZT4xNDA8L3ZvbHVtZT48bnVt

YmVyPjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+cGVyaXBoZXJhbCBhcnRlcmlhbCBkaXNl

YXNlPC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCBvdXRjb21lPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWcgMTM8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI0LTQ1MzkgKEVsZWN0cm9uaWMpJiN4RDswMDA5

LTczMjIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMxMjM4NzEzPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8zMTIzODcxMzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+MTAuMTE2MS9DSVJDVUxBVElPTkFIQS4xMTkuMDM5NzczPC9lbGVjdHJvbmlj

LXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 18 ALI was strongly associated with subsequent MACE (adjusted hazard ratio [aHR] 1.4, 95%CI 1.0–2.1), all-cause mortality (aHR 3.3, 95%CI 2.4–4.6), and major amputation (aHR 34.2, 95%CI 9.7–20.8). Previous LER, baseline atrial fibrillation, and baseline ABI ≤0.60 were independent predictors of ALI. In this trial, a second analysis showed that 12.5% of patients experienced LER during the trial.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXVtZ2FydG5lcjwvQXV0aG9yPjxZZWFyPjIwMTg8L1ll

YXI+PFJlY051bT40MTE0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNj

cmlwdCI+MTk8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTE0PC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6

YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NzAxOTQ0MDQiPjQxMTQ8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJhdW1nYXJ0bmVyLCBJLjwvYXV0

aG9yPjxhdXRob3I+Tm9yZ3JlbiwgTC48L2F1dGhvcj48YXV0aG9yPkZvd2tlcywgRi4gRy4gUi48

L2F1dGhvcj48YXV0aG9yPk11bGRlciwgSC48L2F1dGhvcj48YXV0aG9yPlBhdGVsLCBNLiBSLjwv

YXV0aG9yPjxhdXRob3I+QmVyZ2VyLCBKLiBTLjwvYXV0aG9yPjxhdXRob3I+Sm9uZXMsIFcuIFMu

PC9hdXRob3I+PGF1dGhvcj5Sb2NraG9sZCwgRi4gVy48L2F1dGhvcj48YXV0aG9yPkthdG9uYSwg

Qi4gRy48L2F1dGhvcj48YXV0aG9yPk1haGFmZmV5LCBLLjwvYXV0aG9yPjxhdXRob3I+SGlhdHQs

IFcuIFIuPC9hdXRob3I+PGF1dGhvcj5FeGVjdXRpdmUsIENvbW1pdHRlZTwvYXV0aG9yPjxhdXRo

b3I+SW52ZXN0aWdhdG9ycyBvZiB0aGUsIEV1Y2xpZCBUcmlhbDwvYXV0aG9yPjwvYXV0aG9ycz48

L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlN3aXNzIENhcmRpb3Zhc2N1bGFyIENlbnRyZSwg

SW5zZWxzcGl0YWwsIERpdmlzaW9uIG9mIEFuZ2lvbG9neSwgQmVybiBVbml2ZXJzaXR5IEhvc3Bp

dGFsLCBVbml2ZXJzaXR5IG9mIEJlcm4sIEJlcm4sIFN3aXR6ZXJsYW5kLiYjeEQ7RmFjdWx0eSBv

ZiBNZWRpY2luZSBhbmQgSGVhbHRoLCBPcmVicm8gVW5pdmVyc2l0eSwgT3JlYnJvLCBTd2VkZW4u

JiN4RDtVc2hlciBJbnN0aXR1dGUgb2YgUG9wdWxhdGlvbiBIZWFsdGggU2NpZW5jZXMgYW5kIElu

Zm9ybWF0aWNzLCBVbml2ZXJzaXR5IG9mIEVkaW5idXJnaCwgRWRpbmJ1cmdoLCBVbml0ZWQgS2lu

Z2RvbS4mI3hEO0R1a2UgQ2xpbmljYWwgUmVzZWFyY2ggSW5zdGl0dXRlLCBEdWtlIFVuaXZlcnNp

dHkgU2Nob29sIG9mIE1lZGljaW5lLCBEdXJoYW0sIE5vcnRoIENhcm9saW5hLiYjeEQ7RGVwYXJ0

bWVudHMgb2YgTWVkaWNpbmUgYW5kIFN1cmdlcnksIE5ldyBZb3JrIFVuaXZlcnNpdHkgU2Nob29s

IG9mIE1lZGljaW5lLCBOZXcgWW9yaywgTmV3IFlvcmsuJiN4RDtBc3RyYVplbmVjYSBHYWl0aGVy

c2J1cmcsIEdhaXRoZXJzYnVyZywgTWFyeWxhbmQuJiN4RDtTdGFuZm9yZCBDZW50ZXIgZm9yIENs

aW5pY2FsIFJlc2VhcmNoLCBTdGFuZm9yZCBVbml2ZXJzaXR5LCBTY2hvb2wgb2YgTWVkaWNpbmUs

IFN0YW5mb3JkLCBDYWxpZm9ybmlhLiYjeEQ7RGl2aXNpb24gb2YgQ2FyZGlvbG9neSBhbmQgQ1BD

IENsaW5pY2FsIFJlc2VhcmNoLCBVbml2ZXJzaXR5IG9mIENvbG9yYWRvIFNjaG9vbCBvZiBNZWRp

Y2luZSwgQXVyb3JhLCBDb2xvcmFkby4gRWxlY3Ryb25pYyBhZGRyZXNzOiBXaWxsLkhpYXR0QFVD

RGVudmVyLmVkdS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5DYXJkaW92YXNjdWxhciBP

dXRjb21lcyBBZnRlciBMb3dlciBFeHRyZW1pdHkgRW5kb3Zhc2N1bGFyIG9yIFN1cmdpY2FsIFJl

dmFzY3VsYXJpemF0aW9uOiBUaGUgRVVDTElEIFRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

PkogQW0gQ29sbCBDYXJkaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjE1NjMt

MTU3MjwvcGFnZXM+PHZvbHVtZT43Mjwvdm9sdW1lPjxudW1iZXI+MTQ8L251bWJlcj48ZWRpdGlv

bj4yMDE4LzA5LzI5PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPkFtcHV0YXRpb24vc3RhdGlzdGljcyAmYW1wOyBudW1lcmljYWwgZGF0YTwva2V5d29y

ZD48a2V5d29yZD5CbG9vZCBWZXNzZWwgUHJvc3RoZXNpcyBJbXBsYW50YXRpb248L2tleXdvcmQ+

PGtleXdvcmQ+RW5kYXJ0ZXJlY3RvbXk8L2tleXdvcmQ+PGtleXdvcmQ+KkVuZG92YXNjdWxhciBQ

cm9jZWR1cmVzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GZW1v

cmFsIEFydGVyeS9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPkhlbW9ycmhhZ2UvZXBpZGVtaW9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5Jc2NoZW1pYS9l

cGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TG93ZXIgRXh0cmVtaXR5LypibG9vZCBzdXBw

bHkvKnN1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NeW9j

YXJkaWFsIEluZmFyY3Rpb24vZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBlcmlwaGVy

YWwgQXJ0ZXJpYWwgRGlzZWFzZS8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5Qb3BsaXRlYWwg

QXJ0ZXJ5L3N1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+U3Ryb2tlL2VwaWRlbWlvbG9neTwva2V5

d29yZD48a2V5d29yZD4qYWN1dGUgbGltYiBpc2NoZW1pYTwva2V5d29yZD48a2V5d29yZD4qY2Fy

ZGlvdmFzY3VsYXIgZXZlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+KmRpYWJldGVzPC9rZXl3b3JkPjxr

ZXl3b3JkPipsb3dlciBleHRyZW1pdHkgcmV2YXNjdWxhcml6YXRpb248L2tleXdvcmQ+PGtleXdv

cmQ+KnBlcmlwaGVyYWwgYXJ0ZXJ5IGRpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+KnNtb2tpbmc8

L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxk

YXRlPk9jdCAyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU1OC0zNTk3IChFbGVj

dHJvbmljKSYjeEQ7MDczNS0xMDk3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDI2

MTk1NTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzAyNjE5NTU8L3VybD48dXJsPmh0dHBzOi8vcGRmLnNj

aWVuY2VkaXJlY3Rhc3NldHMuY29tLzI3MTAyNy8xLXMyLjAtUzA3MzUxMDk3MTdYMDA0NDIvMS1z

Mi4wLVMwNzM1MTA5NzE4MzU3NDk4L21haW4ucGRmP1gtQW16LVNlY3VyaXR5LVRva2VuPUFnb0pi

M0pwWjJsdVgyVmpFRVFhQ1hWekxXVmhjM1F0TVNKSU1FWUNJUURaRzA4ZURNOGdVbFJwY3RrWVJn

Z2V2NkhzNUlCbTZialdqdVl3VEZmRXBBSWhBTUREaFRSZFE3cnhaYWdqamdWaVhpZyUyRnQxTEFi

RUVvbCUyRkxDbG8lMkZvcCUyRmMwS3RvRENDMFFBaG9NTURVNU1EQXpOVFEyT0RZMUlneU8xenFa

aDZZU1NYQ2Zya3dxdHdNUDkzbkh1ek9lbjNEZ2FKeGhVQ1NlZUs0MTl6RzBZZjV4ckJkaG9sVHY4

RVNkbGJsQ3pKb0l6TXdBbHgyZ1ZQdmg2TCUyRjhRMmp0MTAlMkIwalNMeGolMkJpaVclMkI1alNC

OWlFTWFjYXdBYm5qQW1uMktuWlAwall5eiUyQmptMkdhUks4c0FQNElDJTJCUW10aGFWSElERE1T

Mzh6ajQlMkZhVWw3SDFGRHV0UWpBM2dqZ2M3JTJGZjFtR01ocmo1aHliQ1ZzdU41N0ZmMDcyYkdV

aUpFRjd6anRFTnAwNUVBZmJyQTdtdHdvSHUlMkIlMkJMTEdYQ2pZdSUyQjY5NE9Ca2IyQlFrQ1Ml

MkZoVUV5VkJ1MUl6SUF6VEg0c1VzOVZNVThyR3IlMkZKZnhtTzQ5dWFFVzkzY3hBaFNVNmZWV2dN

dW1tNyUyQlNwYnVCeHZpQnowb3kyNXlhZiUyQiUyRnlobXV5SzdXSjBhZE1UJTJCVll4MDYxVDhL

aDVsSlF1Vmg0dENkdTJISHVwa3lKS0IxOTUzJTJGbHIwUFB0ZVRtT0J6ajJYenpUdHFIQzRrclF4

c3JlWkIlMkZNZnl5OGdsNjF0YTlFNlBQNTZUZ3JyN1p3RHlrVFZnbktkU3BWZ3E0NVg3MEVwaFV0

bDFEa3dDNzNHWkp1SUtTTVYwdThTNXRWVzhaWlhwbmU3cWtnMGlaaER3SzZzVjlMRlhBUTdGTjho

T1FJUWNSNDM4MzhYa1BnWkY3RnAwSGQyZnVkTTFhTE9rd1NTMEQ0R1lsRkk2WUliN0klMkZuYjRy

bFVhaDdPekVRVTJmbU1KblkzT3dGT3JNQiUyQiUyQmlQeGJRUFJWUyUyQiUyRm1EdWc3SVE0QUtG

blolMkZ2U3JLRTRKQlA5OGtJaVQwUWNWb3FTcFQ0ZlNNaktUVzdwWFhRMU1ZTnIwTWN3YmdRYWRS

NHNQOHlkaDRuMDElMkZjUENsNllZWDRVb2tNQ3FVazBPZzY2SXN1R0lzMEUxUXFnWkoxb2RNOXlt

NWdQWUlRcW81emJtS092YjdJRSUyQmZmR29CdURvRnlGTmk2U3cxVTl6SkVjYyUyQnBJQ2ptOTVF

RHdNdmNPTkVaJTJGUXNOTmlSck1NR3dMZEYwJTJCNWdHd0Q3SG1qVmJYakFxbkVlVFIwMHNrc2Ml

M0QmYW1wO1gtQW16LUFsZ29yaXRobT1BV1M0LUhNQUMtU0hBMjU2JmFtcDtYLUFtei1EYXRlPTIw

MTkxMDA0VDEzMDkwMlomYW1wO1gtQW16LVNpZ25lZEhlYWRlcnM9aG9zdCZhbXA7WC1BbXotRXhw

aXJlcz0zMDAmYW1wO1gtQW16LUNyZWRlbnRpYWw9QVNJQVEzUEhDVlRZUzVXTVk0RkklMkYyMDE5

MTAwNCUyRnVzLWVhc3QtMSUyRnMzJTJGYXdzNF9yZXF1ZXN0JmFtcDtYLUFtei1TaWduYXR1cmU9

Zjg2YjZmNjNlMjMwZmQxNjg2ZDFlZmRhNTgwN2RjMDNkYzc4NDk2MTE2NWM4ZjgyZGQzYTk3YmY1

ZGJjNGQ0NSZhbXA7aGFzaD05YzllNTI5NGQ5YmUyNGYzNDc4MjQ2ZDE2ZDJjNjFhMWIwZWZkZGE0

YmEyYTkzYjY1ZTg1ZTU2OTU2NzA0NDIyJmFtcDtob3N0PTY4MDQyYzk0MzU5MTAxM2FjMmIyNDMw

YTg5YjI3MGY2YWYyYzc2ZDhkZmQwODZhMDcxNzZhZmU3Yzc2YzJjNjEmYW1wO3BpaT1TMDczNTEw

OTcxODM1NzQ5OCZhbXA7dGlkPXNwZGYtMmI5NGE3ZTgtN2U1YS00NDkxLWE2MTMtNDdiMThhZGQ0

YmE2JmFtcDtzaWQ9NDQ0M2IwODgzMjYzZDQ0ZDA3NDlhNGMyMGU4Y2U1NDFmNTBmZ3hycWImYW1w

O3R5cGU9Y2xpZW50PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291

cmNlLW51bT4xMC4xMDE2L2ouamFjYy4yMDE4LjA3LjA0NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXVtZ2FydG5lcjwvQXV0aG9yPjxZZWFyPjIwMTg8L1ll

YXI+PFJlY051bT40MTE0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNj

cmlwdCI+MTk8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTE0PC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6

YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NzAxOTQ0MDQiPjQxMTQ8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJhdW1nYXJ0bmVyLCBJLjwvYXV0

aG9yPjxhdXRob3I+Tm9yZ3JlbiwgTC48L2F1dGhvcj48YXV0aG9yPkZvd2tlcywgRi4gRy4gUi48

L2F1dGhvcj48YXV0aG9yPk11bGRlciwgSC48L2F1dGhvcj48YXV0aG9yPlBhdGVsLCBNLiBSLjwv

YXV0aG9yPjxhdXRob3I+QmVyZ2VyLCBKLiBTLjwvYXV0aG9yPjxhdXRob3I+Sm9uZXMsIFcuIFMu

PC9hdXRob3I+PGF1dGhvcj5Sb2NraG9sZCwgRi4gVy48L2F1dGhvcj48YXV0aG9yPkthdG9uYSwg

Qi4gRy48L2F1dGhvcj48YXV0aG9yPk1haGFmZmV5LCBLLjwvYXV0aG9yPjxhdXRob3I+SGlhdHQs

IFcuIFIuPC9hdXRob3I+PGF1dGhvcj5FeGVjdXRpdmUsIENvbW1pdHRlZTwvYXV0aG9yPjxhdXRo

b3I+SW52ZXN0aWdhdG9ycyBvZiB0aGUsIEV1Y2xpZCBUcmlhbDwvYXV0aG9yPjwvYXV0aG9ycz48

L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlN3aXNzIENhcmRpb3Zhc2N1bGFyIENlbnRyZSwg

SW5zZWxzcGl0YWwsIERpdmlzaW9uIG9mIEFuZ2lvbG9neSwgQmVybiBVbml2ZXJzaXR5IEhvc3Bp

dGFsLCBVbml2ZXJzaXR5IG9mIEJlcm4sIEJlcm4sIFN3aXR6ZXJsYW5kLiYjeEQ7RmFjdWx0eSBv

ZiBNZWRpY2luZSBhbmQgSGVhbHRoLCBPcmVicm8gVW5pdmVyc2l0eSwgT3JlYnJvLCBTd2VkZW4u

JiN4RDtVc2hlciBJbnN0aXR1dGUgb2YgUG9wdWxhdGlvbiBIZWFsdGggU2NpZW5jZXMgYW5kIElu

Zm9ybWF0aWNzLCBVbml2ZXJzaXR5IG9mIEVkaW5idXJnaCwgRWRpbmJ1cmdoLCBVbml0ZWQgS2lu

Z2RvbS4mI3hEO0R1a2UgQ2xpbmljYWwgUmVzZWFyY2ggSW5zdGl0dXRlLCBEdWtlIFVuaXZlcnNp

dHkgU2Nob29sIG9mIE1lZGljaW5lLCBEdXJoYW0sIE5vcnRoIENhcm9saW5hLiYjeEQ7RGVwYXJ0

bWVudHMgb2YgTWVkaWNpbmUgYW5kIFN1cmdlcnksIE5ldyBZb3JrIFVuaXZlcnNpdHkgU2Nob29s

IG9mIE1lZGljaW5lLCBOZXcgWW9yaywgTmV3IFlvcmsuJiN4RDtBc3RyYVplbmVjYSBHYWl0aGVy

c2J1cmcsIEdhaXRoZXJzYnVyZywgTWFyeWxhbmQuJiN4RDtTdGFuZm9yZCBDZW50ZXIgZm9yIENs

aW5pY2FsIFJlc2VhcmNoLCBTdGFuZm9yZCBVbml2ZXJzaXR5LCBTY2hvb2wgb2YgTWVkaWNpbmUs

IFN0YW5mb3JkLCBDYWxpZm9ybmlhLiYjeEQ7RGl2aXNpb24gb2YgQ2FyZGlvbG9neSBhbmQgQ1BD

IENsaW5pY2FsIFJlc2VhcmNoLCBVbml2ZXJzaXR5IG9mIENvbG9yYWRvIFNjaG9vbCBvZiBNZWRp

Y2luZSwgQXVyb3JhLCBDb2xvcmFkby4gRWxlY3Ryb25pYyBhZGRyZXNzOiBXaWxsLkhpYXR0QFVD

RGVudmVyLmVkdS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5DYXJkaW92YXNjdWxhciBP

dXRjb21lcyBBZnRlciBMb3dlciBFeHRyZW1pdHkgRW5kb3Zhc2N1bGFyIG9yIFN1cmdpY2FsIFJl

dmFzY3VsYXJpemF0aW9uOiBUaGUgRVVDTElEIFRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

PkogQW0gQ29sbCBDYXJkaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjE1NjMt

MTU3MjwvcGFnZXM+PHZvbHVtZT43Mjwvdm9sdW1lPjxudW1iZXI+MTQ8L251bWJlcj48ZWRpdGlv

bj4yMDE4LzA5LzI5PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPkFtcHV0YXRpb24vc3RhdGlzdGljcyAmYW1wOyBudW1lcmljYWwgZGF0YTwva2V5d29y

ZD48a2V5d29yZD5CbG9vZCBWZXNzZWwgUHJvc3RoZXNpcyBJbXBsYW50YXRpb248L2tleXdvcmQ+

PGtleXdvcmQ+RW5kYXJ0ZXJlY3RvbXk8L2tleXdvcmQ+PGtleXdvcmQ+KkVuZG92YXNjdWxhciBQ

cm9jZWR1cmVzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GZW1v

cmFsIEFydGVyeS9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPkhlbW9ycmhhZ2UvZXBpZGVtaW9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5Jc2NoZW1pYS9l

cGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TG93ZXIgRXh0cmVtaXR5LypibG9vZCBzdXBw

bHkvKnN1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NeW9j

YXJkaWFsIEluZmFyY3Rpb24vZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBlcmlwaGVy

YWwgQXJ0ZXJpYWwgRGlzZWFzZS8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5Qb3BsaXRlYWwg

QXJ0ZXJ5L3N1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+U3Ryb2tlL2VwaWRlbWlvbG9neTwva2V5

d29yZD48a2V5d29yZD4qYWN1dGUgbGltYiBpc2NoZW1pYTwva2V5d29yZD48a2V5d29yZD4qY2Fy

ZGlvdmFzY3VsYXIgZXZlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+KmRpYWJldGVzPC9rZXl3b3JkPjxr

ZXl3b3JkPipsb3dlciBleHRyZW1pdHkgcmV2YXNjdWxhcml6YXRpb248L2tleXdvcmQ+PGtleXdv

cmQ+KnBlcmlwaGVyYWwgYXJ0ZXJ5IGRpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+KnNtb2tpbmc8

L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxk

YXRlPk9jdCAyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU1OC0zNTk3IChFbGVj

dHJvbmljKSYjeEQ7MDczNS0xMDk3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDI2

MTk1NTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzAyNjE5NTU8L3VybD48dXJsPmh0dHBzOi8vcGRmLnNj

aWVuY2VkaXJlY3Rhc3NldHMuY29tLzI3MTAyNy8xLXMyLjAtUzA3MzUxMDk3MTdYMDA0NDIvMS1z

Mi4wLVMwNzM1MTA5NzE4MzU3NDk4L21haW4ucGRmP1gtQW16LVNlY3VyaXR5LVRva2VuPUFnb0pi

M0pwWjJsdVgyVmpFRVFhQ1hWekxXVmhjM1F0TVNKSU1FWUNJUURaRzA4ZURNOGdVbFJwY3RrWVJn

Z2V2NkhzNUlCbTZialdqdVl3VEZmRXBBSWhBTUREaFRSZFE3cnhaYWdqamdWaVhpZyUyRnQxTEFi

RUVvbCUyRkxDbG8lMkZvcCUyRmMwS3RvRENDMFFBaG9NTURVNU1EQXpOVFEyT0RZMUlneU8xenFa

aDZZU1NYQ2Zya3dxdHdNUDkzbkh1ek9lbjNEZ2FKeGhVQ1NlZUs0MTl6RzBZZjV4ckJkaG9sVHY4

RVNkbGJsQ3pKb0l6TXdBbHgyZ1ZQdmg2TCUyRjhRMmp0MTAlMkIwalNMeGolMkJpaVclMkI1alNC

OWlFTWFjYXdBYm5qQW1uMktuWlAwall5eiUyQmptMkdhUks4c0FQNElDJTJCUW10aGFWSElERE1T

Mzh6ajQlMkZhVWw3SDFGRHV0UWpBM2dqZ2M3JTJGZjFtR01ocmo1aHliQ1ZzdU41N0ZmMDcyYkdV

aUpFRjd6anRFTnAwNUVBZmJyQTdtdHdvSHUlMkIlMkJMTEdYQ2pZdSUyQjY5NE9Ca2IyQlFrQ1Ml

MkZoVUV5VkJ1MUl6SUF6VEg0c1VzOVZNVThyR3IlMkZKZnhtTzQ5dWFFVzkzY3hBaFNVNmZWV2dN

dW1tNyUyQlNwYnVCeHZpQnowb3kyNXlhZiUyQiUyRnlobXV5SzdXSjBhZE1UJTJCVll4MDYxVDhL

aDVsSlF1Vmg0dENkdTJISHVwa3lKS0IxOTUzJTJGbHIwUFB0ZVRtT0J6ajJYenpUdHFIQzRrclF4

c3JlWkIlMkZNZnl5OGdsNjF0YTlFNlBQNTZUZ3JyN1p3RHlrVFZnbktkU3BWZ3E0NVg3MEVwaFV0

bDFEa3dDNzNHWkp1SUtTTVYwdThTNXRWVzhaWlhwbmU3cWtnMGlaaER3SzZzVjlMRlhBUTdGTjho

T1FJUWNSNDM4MzhYa1BnWkY3RnAwSGQyZnVkTTFhTE9rd1NTMEQ0R1lsRkk2WUliN0klMkZuYjRy

bFVhaDdPekVRVTJmbU1KblkzT3dGT3JNQiUyQiUyQmlQeGJRUFJWUyUyQiUyRm1EdWc3SVE0QUtG

blolMkZ2U3JLRTRKQlA5OGtJaVQwUWNWb3FTcFQ0ZlNNaktUVzdwWFhRMU1ZTnIwTWN3YmdRYWRS

NHNQOHlkaDRuMDElMkZjUENsNllZWDRVb2tNQ3FVazBPZzY2SXN1R0lzMEUxUXFnWkoxb2RNOXlt

NWdQWUlRcW81emJtS092YjdJRSUyQmZmR29CdURvRnlGTmk2U3cxVTl6SkVjYyUyQnBJQ2ptOTVF

RHdNdmNPTkVaJTJGUXNOTmlSck1NR3dMZEYwJTJCNWdHd0Q3SG1qVmJYakFxbkVlVFIwMHNrc2Ml

M0QmYW1wO1gtQW16LUFsZ29yaXRobT1BV1M0LUhNQUMtU0hBMjU2JmFtcDtYLUFtei1EYXRlPTIw

MTkxMDA0VDEzMDkwMlomYW1wO1gtQW16LVNpZ25lZEhlYWRlcnM9aG9zdCZhbXA7WC1BbXotRXhw

aXJlcz0zMDAmYW1wO1gtQW16LUNyZWRlbnRpYWw9QVNJQVEzUEhDVlRZUzVXTVk0RkklMkYyMDE5

MTAwNCUyRnVzLWVhc3QtMSUyRnMzJTJGYXdzNF9yZXF1ZXN0JmFtcDtYLUFtei1TaWduYXR1cmU9

Zjg2YjZmNjNlMjMwZmQxNjg2ZDFlZmRhNTgwN2RjMDNkYzc4NDk2MTE2NWM4ZjgyZGQzYTk3YmY1

ZGJjNGQ0NSZhbXA7aGFzaD05YzllNTI5NGQ5YmUyNGYzNDc4MjQ2ZDE2ZDJjNjFhMWIwZWZkZGE0

YmEyYTkzYjY1ZTg1ZTU2OTU2NzA0NDIyJmFtcDtob3N0PTY4MDQyYzk0MzU5MTAxM2FjMmIyNDMw

YTg5YjI3MGY2YWYyYzc2ZDhkZmQwODZhMDcxNzZhZmU3Yzc2YzJjNjEmYW1wO3BpaT1TMDczNTEw

OTcxODM1NzQ5OCZhbXA7dGlkPXNwZGYtMmI5NGE3ZTgtN2U1YS00NDkxLWE2MTMtNDdiMThhZGQ0

YmE2JmFtcDtzaWQ9NDQ0M2IwODgzMjYzZDQ0ZDA3NDlhNGMyMGU4Y2U1NDFmNTBmZ3hycWImYW1w

O3R5cGU9Y2xpZW50PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291

cmNlLW51bT4xMC4xMDE2L2ouamFjYy4yMDE4LjA3LjA0NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA 19 Independent predictors of post-randomization LER were prior history and type of prior LER (p<0.0001), living in North America or Europe (p<0.0001), presence of limb symptoms at baseline (HR 1.3; 95%CI 1.2–1.5), diabetes (HR 1.3; 95%CI 1.1–1.4), and smoking (HR 1.2; 95%CI 1.1–1.4). Cardiac and limb events were numerically higher in patients undergoing surgical procedures, but surgical patients experienced fewer LERs after the index LER.A growing proportion of ALI hospitalizations occurs in cancer patients who experience arterial thromboembolism. In the population-based Surveillance Epidemiology and End Results-Medicare linked dataset, 374,331 patients ≥67 years with primary diagnosis of breast, lung, prostate, colorectal, bladder, uterine, pancreatic, gastric cancer, or non-Hodgkin lymphoma were identified. ADDIN EN.CITE <EndNote><Cite><Author>Navi</Author><Year>2019</Year><RecNum>4084</RecNum><DisplayText><style face="superscript">20</style></DisplayText><record><rec-number>4084</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1569593653">4084</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Navi, B. B.</author><author>Reiner, A. S.</author><author>Kamel, H.</author><author>Iadecola, C.</author><author>Okin, P. M.</author><author>Tagawa, S. T.</author><author>Panageas, K. S.</author><author>DeAngelis, L. M.</author></authors></contributors><auth-address>Department of Neurology and.&#xD;Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY.&#xD;Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY.&#xD;Department of Medicine, Division of Cardiology, and.&#xD;Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY; and.&#xD;Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.</auth-address><titles><title>Arterial thromboembolic events preceding the diagnosis of cancer in older persons</title><secondary-title>Blood</secondary-title></titles><pages>781-789</pages><volume>133</volume><number>8</number><dates><year>2019</year><pub-dates><date>Feb 21</date></pub-dates></dates><isbn>1528-0020 (Electronic)&#xD;0006-4971 (Linking)</isbn><accession-num>30578253</accession-num><urls><related-urls><url> Risk of arterial thromboembolic events began to increase 150 days before date of cancer diagnosis in older patients and peaked in the 30 days before cancer diagnosis, when 0.62% of patients suffered an arterial thromboembolic event vs 0.11% in control subjects (odds ratio: 5.63; 95%CI 5.07-6.25).Lipid lowering is a key element of LEAD treatment PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYm95YW5zPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48

UmVjTnVtPjM2MTY8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij40PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MzYxNjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMy

cjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTI1MDg0MzQwIj4zNjE2PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BYm95YW5zLCBWLjwvYXV0aG9yPjxhdXRo

b3I+UmljY28sIEouIEIuPC9hdXRob3I+PGF1dGhvcj5CYXJ0ZWxpbmssIE0uIEUuIEwuPC9hdXRo

b3I+PGF1dGhvcj5Cam9yY2ssIE0uPC9hdXRob3I+PGF1dGhvcj5Ccm9kbWFubiwgTS48L2F1dGhv

cj48YXV0aG9yPkNvaG5lcnQsIFQuPC9hdXRob3I+PGF1dGhvcj5Db2xsZXQsIEouIFAuPC9hdXRo

b3I+PGF1dGhvcj5DemVybnksIE0uPC9hdXRob3I+PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhv

cj48YXV0aG9yPkRlYnVzLCBTLjwvYXV0aG9yPjxhdXRob3I+RXNwaW5vbGEtS2xlaW4sIEMuPC9h

dXRob3I+PGF1dGhvcj5LYWhhbiwgVC48L2F1dGhvcj48YXV0aG9yPktvd25hdG9yLCBTLjwvYXV0

aG9yPjxhdXRob3I+TWF6em9sYWksIEwuPC9hdXRob3I+PGF1dGhvcj5OYXlsb3IsIEEuIFIuPC9h

dXRob3I+PGF1dGhvcj5Sb2ZmaSwgTS48L2F1dGhvcj48YXV0aG9yPlJvdGhlciwgSi48L2F1dGhv

cj48YXV0aG9yPlNwcnluZ2VyLCBNLjwvYXV0aG9yPjxhdXRob3I+VGVuZGVyYSwgTS48L2F1dGhv

cj48YXV0aG9yPlRlcGUsIEcuPC9hdXRob3I+PGF1dGhvcj5WZW5lcm1vLCBNLjwvYXV0aG9yPjxh

dXRob3I+VmxhY2hvcG91bG9zLCBDLjwvYXV0aG9yPjxhdXRob3I+RGVzb3JtYWlzLCBJLjwvYXV0

aG9yPjxhdXRob3I+RS4gUy4gQy4gU2NpZW50aWZpYyBEb2N1bWVudCBHcm91cDwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE3IEVTQyBHdWlkZWxpbmVz

IG9uIHRoZSBEaWFnbm9zaXMgYW5kIFRyZWF0bWVudCBvZiBQZXJpcGhlcmFsIEFydGVyaWFsIERp

c2Vhc2VzLCBpbiBjb2xsYWJvcmF0aW9uIHdpdGggdGhlIEV1cm9wZWFuIFNvY2lldHkgZm9yIFZh

c2N1bGFyIFN1cmdlcnkgKEVTVlMpOiBEb2N1bWVudCBjb3ZlcmluZyBhdGhlcm9zY2xlcm90aWMg

ZGlzZWFzZSBvZiBleHRyYWNyYW5pYWwgY2Fyb3RpZCBhbmQgdmVydGVicmFsLCBtZXNlbnRlcmlj

LCByZW5hbCwgdXBwZXIgYW5kIGxvd2VyIGV4dHJlbWl0eSBhcnRlcmllc0VuZG9yc2VkIGJ5OiB0

aGUgRXVyb3BlYW4gU3Ryb2tlIE9yZ2FuaXphdGlvbiAoRVNPKVRoZSBUYXNrIEZvcmNlIGZvciB0

aGUgRGlhZ25vc2lzIGFuZCBUcmVhdG1lbnQgb2YgUGVyaXBoZXJhbCBBcnRlcmlhbCBEaXNlYXNl

cyBvZiB0aGUgRXVyb3BlYW4gU29jaWV0eSBvZiBDYXJkaW9sb2d5IChFU0MpIGFuZCBvZiB0aGUg

RXVyb3BlYW4gU29jaWV0eSBmb3IgVmFzY3VsYXIgU3VyZ2VyeSAoRVNWUyk8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1cm9w

ZWFuIGhlYXJ0IGpvdXJuYWw8L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+NzYzLTgxNjwvcGFn

ZXM+PHZvbHVtZT4zOTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE4

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48

aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjI4ODg2NjIwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI4ODg2NjIwPC91cmw+

PHVybD5odHRwczovL3dhdGVybWFyay5zaWx2ZXJjaGFpci5jb20vZWh4MDk1LnBkZj90b2tlbj1B

UUVDQUhpMjA4QkU0OU9vYW45a2toV19FcmN5N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQWNVd2dn

SEJCZ2txaGtpRzl3MEJCd2FnZ2dHeU1JSUJyZ0lCQURDQ0FhY0dDU3FHU0liM0RRRUhBVEFlQmds

Z2hrZ0JaUU1FQVM0d0VRUU1iY0Z6c081eWFfOWJIUlFCQWdFUWdJSUJlRjNmd2wxMGNIOU9pbFZR

VVJ5ZGcyTFVtT3hQdk1OcE1KdW4zdFM4MmVocnBheEZoZXFFa1hJOW9HT1FiZzRwVlgxSWpFTm15

LXNOLUd1Z0NxZDdFZDNqbF82R1RCd0t1aXJxdEpsWjZSc1ZfNG1DOE9qb21nOFZ4cGhzVWZMcWN0

bEZwZ29hVUNiVDlsQUNMbkNYajZfam1wbWc3Y3dqb005SldMRExEWTEzNmgzY2cwMDRxN1B6dW9y

clZidEJSbmNldjNFNlgwVXFPck5PY19xaXZoQUgwU2VFd1RvTF9jVTQ0dld3M3NXbkhBWlQ1YnRL

akx4Wm0yZWUzQmlNdjRJVGIyTE1vckpkZW90SFRsNXY1SWpxcFJlQ2hBcjY3LUd6NEo1NUlYX19K

dEdkdUF2bkNld0hWckpiWVVCRlc3UXFvckFJbGNzX19JNDdGYTJ5QkszV3VQN1BXbTBWTm4yXzBk

bHVvTFh2c2ktNE1vdTc3TWR2ZXVRb2pSN2RQS09WWk14Y1Rwb3diOVE5NUFYSzcxc05NcXhXMkg5

cHBUejd6aTk3T3ZDbEI5N24yZUk1alNsZkxYLVdYNEdYSGZwYlpsQXJ2UVBLS1lLbXpQUDNyZXBK

ckRKMm9XLU8tdGlWYm16MnlkbHM4LWM4TDRHZXJoczwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh4MDk1PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYm95YW5zPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48

UmVjTnVtPjM2MTY8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij40PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MzYxNjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMy

cjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTI1MDg0MzQwIj4zNjE2PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BYm95YW5zLCBWLjwvYXV0aG9yPjxhdXRo

b3I+UmljY28sIEouIEIuPC9hdXRob3I+PGF1dGhvcj5CYXJ0ZWxpbmssIE0uIEUuIEwuPC9hdXRo

b3I+PGF1dGhvcj5Cam9yY2ssIE0uPC9hdXRob3I+PGF1dGhvcj5Ccm9kbWFubiwgTS48L2F1dGhv

cj48YXV0aG9yPkNvaG5lcnQsIFQuPC9hdXRob3I+PGF1dGhvcj5Db2xsZXQsIEouIFAuPC9hdXRo

b3I+PGF1dGhvcj5DemVybnksIE0uPC9hdXRob3I+PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhv

cj48YXV0aG9yPkRlYnVzLCBTLjwvYXV0aG9yPjxhdXRob3I+RXNwaW5vbGEtS2xlaW4sIEMuPC9h

dXRob3I+PGF1dGhvcj5LYWhhbiwgVC48L2F1dGhvcj48YXV0aG9yPktvd25hdG9yLCBTLjwvYXV0

aG9yPjxhdXRob3I+TWF6em9sYWksIEwuPC9hdXRob3I+PGF1dGhvcj5OYXlsb3IsIEEuIFIuPC9h

dXRob3I+PGF1dGhvcj5Sb2ZmaSwgTS48L2F1dGhvcj48YXV0aG9yPlJvdGhlciwgSi48L2F1dGhv

cj48YXV0aG9yPlNwcnluZ2VyLCBNLjwvYXV0aG9yPjxhdXRob3I+VGVuZGVyYSwgTS48L2F1dGhv

cj48YXV0aG9yPlRlcGUsIEcuPC9hdXRob3I+PGF1dGhvcj5WZW5lcm1vLCBNLjwvYXV0aG9yPjxh

dXRob3I+VmxhY2hvcG91bG9zLCBDLjwvYXV0aG9yPjxhdXRob3I+RGVzb3JtYWlzLCBJLjwvYXV0

aG9yPjxhdXRob3I+RS4gUy4gQy4gU2NpZW50aWZpYyBEb2N1bWVudCBHcm91cDwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE3IEVTQyBHdWlkZWxpbmVz

IG9uIHRoZSBEaWFnbm9zaXMgYW5kIFRyZWF0bWVudCBvZiBQZXJpcGhlcmFsIEFydGVyaWFsIERp

c2Vhc2VzLCBpbiBjb2xsYWJvcmF0aW9uIHdpdGggdGhlIEV1cm9wZWFuIFNvY2lldHkgZm9yIFZh

c2N1bGFyIFN1cmdlcnkgKEVTVlMpOiBEb2N1bWVudCBjb3ZlcmluZyBhdGhlcm9zY2xlcm90aWMg

ZGlzZWFzZSBvZiBleHRyYWNyYW5pYWwgY2Fyb3RpZCBhbmQgdmVydGVicmFsLCBtZXNlbnRlcmlj

LCByZW5hbCwgdXBwZXIgYW5kIGxvd2VyIGV4dHJlbWl0eSBhcnRlcmllc0VuZG9yc2VkIGJ5OiB0

aGUgRXVyb3BlYW4gU3Ryb2tlIE9yZ2FuaXphdGlvbiAoRVNPKVRoZSBUYXNrIEZvcmNlIGZvciB0

aGUgRGlhZ25vc2lzIGFuZCBUcmVhdG1lbnQgb2YgUGVyaXBoZXJhbCBBcnRlcmlhbCBEaXNlYXNl

cyBvZiB0aGUgRXVyb3BlYW4gU29jaWV0eSBvZiBDYXJkaW9sb2d5IChFU0MpIGFuZCBvZiB0aGUg

RXVyb3BlYW4gU29jaWV0eSBmb3IgVmFzY3VsYXIgU3VyZ2VyeSAoRVNWUyk8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1cm9w

ZWFuIGhlYXJ0IGpvdXJuYWw8L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+NzYzLTgxNjwvcGFn

ZXM+PHZvbHVtZT4zOTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE4

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48

aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjI4ODg2NjIwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI4ODg2NjIwPC91cmw+

PHVybD5odHRwczovL3dhdGVybWFyay5zaWx2ZXJjaGFpci5jb20vZWh4MDk1LnBkZj90b2tlbj1B

UUVDQUhpMjA4QkU0OU9vYW45a2toV19FcmN5N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQWNVd2dn

SEJCZ2txaGtpRzl3MEJCd2FnZ2dHeU1JSUJyZ0lCQURDQ0FhY0dDU3FHU0liM0RRRUhBVEFlQmds

Z2hrZ0JaUU1FQVM0d0VRUU1iY0Z6c081eWFfOWJIUlFCQWdFUWdJSUJlRjNmd2wxMGNIOU9pbFZR

VVJ5ZGcyTFVtT3hQdk1OcE1KdW4zdFM4MmVocnBheEZoZXFFa1hJOW9HT1FiZzRwVlgxSWpFTm15

LXNOLUd1Z0NxZDdFZDNqbF82R1RCd0t1aXJxdEpsWjZSc1ZfNG1DOE9qb21nOFZ4cGhzVWZMcWN0

bEZwZ29hVUNiVDlsQUNMbkNYajZfam1wbWc3Y3dqb005SldMRExEWTEzNmgzY2cwMDRxN1B6dW9y

clZidEJSbmNldjNFNlgwVXFPck5PY19xaXZoQUgwU2VFd1RvTF9jVTQ0dld3M3NXbkhBWlQ1YnRL

akx4Wm0yZWUzQmlNdjRJVGIyTE1vckpkZW90SFRsNXY1SWpxcFJlQ2hBcjY3LUd6NEo1NUlYX19K

dEdkdUF2bkNld0hWckpiWVVCRlc3UXFvckFJbGNzX19JNDdGYTJ5QkszV3VQN1BXbTBWTm4yXzBk

bHVvTFh2c2ktNE1vdTc3TWR2ZXVRb2pSN2RQS09WWk14Y1Rwb3diOVE5NUFYSzcxc05NcXhXMkg5

cHBUejd6aTk3T3ZDbEI5N24yZUk1alNsZkxYLVdYNEdYSGZwYlpsQXJ2UVBLS1lLbXpQUDNyZXBK

ckRKMm9XLU8tdGlWYm16MnlkbHM4LWM4TDRHZXJoczwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh4MDk1PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA 4 The 2019 ESC guidelines recommend a LDL-cholesterol reduction of ≥50% and a goal of <55 mg/dL (1.4 mmol/L) for LEAD patients, to be achieved with statins, plus ezetimibe and PCSK9 inhibitors if needed.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWNoPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQwODc8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4x

MDwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwODc8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2VzMnI3

NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTYwNTQyNyI+NDA4Nzwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFjaCwgRi48L2F1dGhvcj48YXV0aG9yPkJh

aWdlbnQsIEMuPC9hdXRob3I+PGF1dGhvcj5DYXRhcGFubywgQS4gTC48L2F1dGhvcj48YXV0aG9y

Pktvc2tpbmFzLCBLLiBDLjwvYXV0aG9yPjxhdXRob3I+Q2FzdWxhLCBNLjwvYXV0aG9yPjxhdXRo

b3I+QmFkaW1vbiwgTC48L2F1dGhvcj48YXV0aG9yPkNoYXBtYW4sIE0uIEouPC9hdXRob3I+PGF1

dGhvcj5EZSBCYWNrZXIsIEcuIEcuPC9hdXRob3I+PGF1dGhvcj5EZWxnYWRvLCBWLjwvYXV0aG9y

PjxhdXRob3I+RmVyZW5jZSwgQi4gQS48L2F1dGhvcj48YXV0aG9yPkdyYWhhbSwgSS4gTS48L2F1

dGhvcj48YXV0aG9yPkhhbGxpZGF5LCBBLjwvYXV0aG9yPjxhdXRob3I+TGFuZG1lc3NlciwgVS48

L2F1dGhvcj48YXV0aG9yPk1paGF5bG92YSwgQi48L2F1dGhvcj48YXV0aG9yPlBlZGVyc2VuLCBU

LiBSLjwvYXV0aG9yPjxhdXRob3I+UmljY2FyZGksIEcuPC9hdXRob3I+PGF1dGhvcj5SaWNodGVy

LCBELiBKLjwvYXV0aG9yPjxhdXRob3I+U2FiYXRpbmUsIE0uIFMuPC9hdXRob3I+PGF1dGhvcj5U

YXNraW5lbiwgTS4gUi48L2F1dGhvcj48YXV0aG9yPlRva2dvem9nbHUsIEwuPC9hdXRob3I+PGF1

dGhvcj5XaWtsdW5kLCBPLjwvYXV0aG9yPjxhdXRob3I+RS4gUy4gQy4gU2NpZW50aWZpYyBEb2N1

bWVudCBHcm91cDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRs

ZT4yMDE5IEVTQy9FQVMgR3VpZGVsaW5lcyBmb3IgdGhlIG1hbmFnZW1lbnQgb2YgZHlzbGlwaWRh

ZW1pYXM6IGxpcGlkIG1vZGlmaWNhdGlvbiB0byByZWR1Y2UgY2FyZGlvdmFzY3VsYXIgcmlzazwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0

bGVzPjxrZXl3b3Jkcz48a2V5d29yZD5HdWlkZWxpbmVzPC9rZXl3b3JkPjxrZXl3b3JkPmFwb2xp

cG9wcm90ZWluIEI8L2tleXdvcmQ+PGtleXdvcmQ+Y2hvbGVzdGVyb2w8L2tleXdvcmQ+PGtleXdv

cmQ+ZHlzbGlwaWRhZW1pYXM8L2tleXdvcmQ+PGtleXdvcmQ+ZmFtaWxpYWwgaHlwZXJjaG9sZXN0

ZXJvbGFlbWlhPC9rZXl3b3JkPjxrZXl3b3JkPmhpZ2gtZGVuc2l0eSBsaXBvcHJvdGVpbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+bGlwb3Byb3RlaW4gcmVtbmFudHM8L2tleXdvcmQ+PGtleXdvcmQ+bGlw

b3Byb3RlaW4oYSk8L2tleXdvcmQ+PGtleXdvcmQ+bG93LWRlbnNpdHkgbGlwb3Byb3RlaW5zPC9r

ZXl3b3JkPjxrZXl3b3JkPnRvdGFsIGNhcmRpb3Zhc2N1bGFyIHJpc2s8L2tleXdvcmQ+PGtleXdv

cmQ+dHJlYXRtZW50IChhZGhlcmVuY2UpPC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCAoZHJ1

Z3MpPC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCAobGlmZXN0eWxlKTwva2V5d29yZD48a2V5

d29yZD50cmlnbHljZXJpZGVzPC9rZXl3b3JkPjxrZXl3b3JkPnZlcnkgbG93LWRlbnNpdHkgbGlw

b3Byb3RlaW5zPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1

Yi1kYXRlcz48ZGF0ZT5BdWcgMzE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIy

LTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Np

b24tbnVtPjMxNTA0NDE4PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMTUwNDQxODwvdXJsPjx1cmw+aHR0

cHM6Ly93YXRlcm1hcmsuc2lsdmVyY2hhaXIuY29tL2VoejQ1NS5wZGY/dG9rZW49QVFFQ0FIaTIw

OEJFNDlPb2FuOWtraFdfRXJjeTdEbTNaTF85Q2YzcWZLQWM0ODV5c2dBQUFvUXdnZ0tBQmdrcWhr

aUc5dzBCQndhZ2dnSnhNSUlDYlFJQkFEQ0NBbVlHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFN

RUFTNHdFUVFNY3h4cEllLWxreXJYSjNMLUFnRVFnSUlDTnpCaG1ySnc5UGhpcUVGR0NfZm90TXZk

a3hMNjRwd0o5dUdkeC1PNUpqWGpMUDR4SV8xQWl6RDVMcE1TNDR4d0VNUmYzMUFsX01sOHJrS3My

UzVPWl8ycFZ6SHNCSG50LWNkYkRIcERlcllYZ0w1eFB0MV8yMWVLS0J2eDJRMHo1VW5Ha2ZLeC1u

VDEzY29mS0Q3bXBnVnp4YnE2U2pORER5U0VSTm1HeXBRMkZvWllBbjFyMi11Z0hzTFd5TVk4eDdI

TzVwVnZTZXhDT3I0eE1rMGo5bC0zOFVhRFM5NzE3SGhES0ktbzZRNEFxNi1Jb3MtVWhWTnZKX292

eU56cHlqSWVMOG82MFRfTWdpZmZteEhnY3NXS1pBUGZhLVQ4N0tBOEJDSGNoeXpCejBRbmZWcUE5

VU5fRXZZVEVWb1pDYXNTLWZQU1MyZmNXbHc3OFNiVzk1ck1fMmoxVUFWRkw5cDVlLWoxMjdoR2hy

Sk9LUF9iM0hxOXdhcm5OREZRRGwwaWdJdlVzOTFFQ2RoWmVtaGh2c21Ka3Ixc2xQcTA2eEhpenI3

Mk5wcW41Z3E5WktycXhsZWNoekJaR0ktQjJhbEFpb280VmM4djF1YXU4blRrZzFQXzJzbDlsTmFF

QWFzdEtpM2owNmNZdVEzMjVVVGlSUjZRNlNPbjNiS0tnWGlVeVdELVFneFI2RHBxbER3MldRbXRx

OGtyR3VobTZETXY1OWE5VEZfWG85cE5FWXJFLVlVeXdObklkUE1ISnFjczFJLUtPQ1Z4dC1HNk9j

cF9nTFNRYkZzREJYWTVTTno4N19wSVBndTFYMnpWSnJNTGZyd1N1bzFUdnhsaWs1VUNVdHhxV1FQ

Y2tQb1c5SU5OUk5RcS0wVjFpbW9LUUJ2aC1Iel9NNUdqYVFsclNHS1BoT2QxY3ZVX0kxeHNXYVdn

LTBWT1RGTk9ScWQ1Z0JrdGlhVUpMQW11b0ViN1l6Z1VfLVZ6dDM0RnlwMjA3Nk1BMEE8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVy

aGVhcnRqL2VoejQ1NTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWNoPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQwODc8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4x

MDwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQwODc8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2VzMnI3

NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTYwNTQyNyI+NDA4Nzwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFjaCwgRi48L2F1dGhvcj48YXV0aG9yPkJh

aWdlbnQsIEMuPC9hdXRob3I+PGF1dGhvcj5DYXRhcGFubywgQS4gTC48L2F1dGhvcj48YXV0aG9y

Pktvc2tpbmFzLCBLLiBDLjwvYXV0aG9yPjxhdXRob3I+Q2FzdWxhLCBNLjwvYXV0aG9yPjxhdXRo

b3I+QmFkaW1vbiwgTC48L2F1dGhvcj48YXV0aG9yPkNoYXBtYW4sIE0uIEouPC9hdXRob3I+PGF1

dGhvcj5EZSBCYWNrZXIsIEcuIEcuPC9hdXRob3I+PGF1dGhvcj5EZWxnYWRvLCBWLjwvYXV0aG9y

PjxhdXRob3I+RmVyZW5jZSwgQi4gQS48L2F1dGhvcj48YXV0aG9yPkdyYWhhbSwgSS4gTS48L2F1

dGhvcj48YXV0aG9yPkhhbGxpZGF5LCBBLjwvYXV0aG9yPjxhdXRob3I+TGFuZG1lc3NlciwgVS48

L2F1dGhvcj48YXV0aG9yPk1paGF5bG92YSwgQi48L2F1dGhvcj48YXV0aG9yPlBlZGVyc2VuLCBU

LiBSLjwvYXV0aG9yPjxhdXRob3I+UmljY2FyZGksIEcuPC9hdXRob3I+PGF1dGhvcj5SaWNodGVy

LCBELiBKLjwvYXV0aG9yPjxhdXRob3I+U2FiYXRpbmUsIE0uIFMuPC9hdXRob3I+PGF1dGhvcj5U

YXNraW5lbiwgTS4gUi48L2F1dGhvcj48YXV0aG9yPlRva2dvem9nbHUsIEwuPC9hdXRob3I+PGF1

dGhvcj5XaWtsdW5kLCBPLjwvYXV0aG9yPjxhdXRob3I+RS4gUy4gQy4gU2NpZW50aWZpYyBEb2N1

bWVudCBHcm91cDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRs

ZT4yMDE5IEVTQy9FQVMgR3VpZGVsaW5lcyBmb3IgdGhlIG1hbmFnZW1lbnQgb2YgZHlzbGlwaWRh

ZW1pYXM6IGxpcGlkIG1vZGlmaWNhdGlvbiB0byByZWR1Y2UgY2FyZGlvdmFzY3VsYXIgcmlzazwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0

bGVzPjxrZXl3b3Jkcz48a2V5d29yZD5HdWlkZWxpbmVzPC9rZXl3b3JkPjxrZXl3b3JkPmFwb2xp

cG9wcm90ZWluIEI8L2tleXdvcmQ+PGtleXdvcmQ+Y2hvbGVzdGVyb2w8L2tleXdvcmQ+PGtleXdv

cmQ+ZHlzbGlwaWRhZW1pYXM8L2tleXdvcmQ+PGtleXdvcmQ+ZmFtaWxpYWwgaHlwZXJjaG9sZXN0

ZXJvbGFlbWlhPC9rZXl3b3JkPjxrZXl3b3JkPmhpZ2gtZGVuc2l0eSBsaXBvcHJvdGVpbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+bGlwb3Byb3RlaW4gcmVtbmFudHM8L2tleXdvcmQ+PGtleXdvcmQ+bGlw

b3Byb3RlaW4oYSk8L2tleXdvcmQ+PGtleXdvcmQ+bG93LWRlbnNpdHkgbGlwb3Byb3RlaW5zPC9r

ZXl3b3JkPjxrZXl3b3JkPnRvdGFsIGNhcmRpb3Zhc2N1bGFyIHJpc2s8L2tleXdvcmQ+PGtleXdv

cmQ+dHJlYXRtZW50IChhZGhlcmVuY2UpPC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCAoZHJ1

Z3MpPC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCAobGlmZXN0eWxlKTwva2V5d29yZD48a2V5

d29yZD50cmlnbHljZXJpZGVzPC9rZXl3b3JkPjxrZXl3b3JkPnZlcnkgbG93LWRlbnNpdHkgbGlw

b3Byb3RlaW5zPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1

Yi1kYXRlcz48ZGF0ZT5BdWcgMzE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIy

LTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Np

b24tbnVtPjMxNTA0NDE4PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMTUwNDQxODwvdXJsPjx1cmw+aHR0

cHM6Ly93YXRlcm1hcmsuc2lsdmVyY2hhaXIuY29tL2VoejQ1NS5wZGY/dG9rZW49QVFFQ0FIaTIw

OEJFNDlPb2FuOWtraFdfRXJjeTdEbTNaTF85Q2YzcWZLQWM0ODV5c2dBQUFvUXdnZ0tBQmdrcWhr

aUc5dzBCQndhZ2dnSnhNSUlDYlFJQkFEQ0NBbVlHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFN

RUFTNHdFUVFNY3h4cEllLWxreXJYSjNMLUFnRVFnSUlDTnpCaG1ySnc5UGhpcUVGR0NfZm90TXZk

a3hMNjRwd0o5dUdkeC1PNUpqWGpMUDR4SV8xQWl6RDVMcE1TNDR4d0VNUmYzMUFsX01sOHJrS3My

UzVPWl8ycFZ6SHNCSG50LWNkYkRIcERlcllYZ0w1eFB0MV8yMWVLS0J2eDJRMHo1VW5Ha2ZLeC1u

VDEzY29mS0Q3bXBnVnp4YnE2U2pORER5U0VSTm1HeXBRMkZvWllBbjFyMi11Z0hzTFd5TVk4eDdI

TzVwVnZTZXhDT3I0eE1rMGo5bC0zOFVhRFM5NzE3SGhES0ktbzZRNEFxNi1Jb3MtVWhWTnZKX292

eU56cHlqSWVMOG82MFRfTWdpZmZteEhnY3NXS1pBUGZhLVQ4N0tBOEJDSGNoeXpCejBRbmZWcUE5

VU5fRXZZVEVWb1pDYXNTLWZQU1MyZmNXbHc3OFNiVzk1ck1fMmoxVUFWRkw5cDVlLWoxMjdoR2hy

Sk9LUF9iM0hxOXdhcm5OREZRRGwwaWdJdlVzOTFFQ2RoWmVtaGh2c21Ka3Ixc2xQcTA2eEhpenI3

Mk5wcW41Z3E5WktycXhsZWNoekJaR0ktQjJhbEFpb280VmM4djF1YXU4blRrZzFQXzJzbDlsTmFF

QWFzdEtpM2owNmNZdVEzMjVVVGlSUjZRNlNPbjNiS0tnWGlVeVdELVFneFI2RHBxbER3MldRbXRx

OGtyR3VobTZETXY1OWE5VEZfWG85cE5FWXJFLVlVeXdObklkUE1ISnFjczFJLUtPQ1Z4dC1HNk9j

cF9nTFNRYkZzREJYWTVTTno4N19wSVBndTFYMnpWSnJNTGZyd1N1bzFUdnhsaWs1VUNVdHhxV1FQ

Y2tQb1c5SU5OUk5RcS0wVjFpbW9LUUJ2aC1Iel9NNUdqYVFsclNHS1BoT2QxY3ZVX0kxeHNXYVdn

LTBWT1RGTk9ScWQ1Z0JrdGlhVUpMQW11b0ViN1l6Z1VfLVZ6dDM0RnlwMjA3Nk1BMEE8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVy

aGVhcnRqL2VoejQ1NTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE.DATA 10 A recent pre-specified analysis of the Evaluation of CV Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab (ODYSSEY OUTCOMES) trial further supports these recommendations.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KdWtlbWE8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxS

ZWNOdW0+NDA3NjwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi

PjIxPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA3NjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMy

cjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDYyNjQ1Ij40MDc2PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5KdWtlbWEsIEouIFcuPC9hdXRob3I+PGF1

dGhvcj5TemFyZWssIE0uPC9hdXRob3I+PGF1dGhvcj5aaWpsc3RyYSwgTC4gRS48L2F1dGhvcj48

YXV0aG9yPmRlIFNpbHZhLCBILiBBLjwvYXV0aG9yPjxhdXRob3I+QmhhdHQsIEQuIEwuPC9hdXRo

b3I+PGF1dGhvcj5CaXR0bmVyLCBWLiBBLjwvYXV0aG9yPjxhdXRob3I+RGlheiwgUi48L2F1dGhv

cj48YXV0aG9yPkVkZWxiZXJnLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+R29vZG1hbiwgUy4gRy48

L2F1dGhvcj48YXV0aG9yPkhhbm90aW4sIEMuPC9hdXRob3I+PGF1dGhvcj5IYXJyaW5ndG9uLCBS

LiBBLjwvYXV0aG9yPjxhdXRob3I+S2FycG92LCBZLjwvYXV0aG9yPjxhdXRob3I+TW9yeXVzZWYs

IEEuPC9hdXRob3I+PGF1dGhvcj5Qb3JkeSwgUi48L2F1dGhvcj48YXV0aG9yPlByaWV0bywgSi4g

Qy48L2F1dGhvcj48YXV0aG9yPlJvZSwgTS4gVC48L2F1dGhvcj48YXV0aG9yPldoaXRlLCBILiBE

LjwvYXV0aG9yPjxhdXRob3I+WmVpaGVyLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+U2Nod2FydHos

IEcuIEcuPC9hdXRob3I+PGF1dGhvcj5TdGVnLCBQLiBHLjwvYXV0aG9yPjxhdXRob3I+T2R5c3Nl

eSBPdXRjb21lcyBDb21taXR0ZWVzPC9hdXRob3I+PGF1dGhvcj5JbnZlc3RpZ2F0b3JzLDwvYXV0

aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2Yg

Q2FyZGlvbG9neSwgTGVpZGVuIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIExlaWRlbiwgVGhl

IE5ldGhlcmxhbmRzLiBFbGVjdHJvbmljIGFkZHJlc3M6IGoudy5qdWtlbWFAbHVtYy5ubC4mI3hE

O1N0YXRlIFVuaXZlcnNpdHkgb2YgTmV3IFlvcmssIERvd25zdGF0ZSBTY2hvb2wgb2YgUHVibGlj

IEhlYWx0aCwgQnJvb2tseW4sIE5ldyBZb3JrLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5

LCBMZWlkZW4gVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciwgTGVpZGVuLCBUaGUgTmV0aGVybGFu

ZHMuJiN4RDtDbGluaWNhbCBUcmlhbHMgVW5pdCwgRmFjdWx0eSBvZiBNZWRpY2luZSwgVW5pdmVy

c2l0eSBvZiBLZWxhbml5YSwgS2VsYW5peWEsIFNyaSBMYW5rYS4mI3hEO0JyaWdoYW0gYW5kIFdv

bWVuJmFwb3M7cyBIb3NwaXRhbCBIZWFydCAmYW1wOyBWYXNjdWxhciBDZW50ZXIgYW5kIEhhcnZh

cmQgTWVkaWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0cy4mI3hEO0RpdmlzaW9uIG9m

IENhcmRpb3Zhc2N1bGFyIERpc2Vhc2UsIFVuaXZlcnNpdHkgb2YgQWxhYmFtYSBhdCBCaXJtaW5n

aGFtLCBCaXJtaW5naGFtLCBBbGFiYW1hLiYjeEQ7TGF0aW5vYW1lcmljYW4gQ2FyZGlvbG9naWNh

bCBTdHVkaWVzLCBDYXJkaW92YXNjdWxhciBJbnN0aXR1dGUgb2YgUm9zYXJpbywgUm9zYXJpbywg

QXJnZW50aW5hLiYjeEQ7U2Fub2ZpLCBCcmlkZ2V3YXRlciwgTmV3IEplcnNleS4mI3hEO0NhbmFk

aWFuIFZJR09VUiBDZW50cmUsIFVuaXZlcnNpdHkgb2YgQWxiZXJ0YSwgRWRtb250b24sIEFsYmVy

dGEsIENhbmFkYTsgU3QuIE1pY2hhZWwmYXBvcztzIEhvc3BpdGFsLCBVbml2ZXJzaXR5IG9mIFRv

cm9udG8sIFRvcm9udG8sIE9udGFyaW8sIENhbmFkYS4mI3hEO1Nhbm9maSwgUGFyaXMsIEZyYW5j

ZS4mI3hEO1N0YW5mb3JkIENlbnRlciBmb3IgQ2xpbmljYWwgUmVzZWFyY2gsIERlcGFydG1lbnQg

b2YgTWVkaWNpbmUsIFN0YW5mb3JkIFVuaXZlcnNpdHksIFN0YW5mb3JkLCBDYWxpZm9ybmlhLiYj

eEQ7UnVzc2lhbiBDYXJkaW9sb2dpY2FsIFNjaWVudGlmaWMtUHJvZHVjdGl2ZSBDb21wbGV4LCBN

b3Njb3csIFJ1c3NpYW4gRmVkZXJhdGlvbi4mI3hEO1JlZ2VuZXJvbiBQaGFybWFjZXV0aWNhbHMs

IEluYy4sIFRhcnJ5dG93biwgTmV3IFlvcmsuJiN4RDtVbml2ZXJzaXR5IG9mIENoaWxlIENsaW5p

Y2FsIEhvc3BpdGFsLCBTYW50aWFnbywgQ2hpbGUuJiN4RDtEdWtlIENsaW5pY2FsIFJlc2VhcmNo

IEluc3RpdHV0ZSwgRHVrZSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBEdXJoYW0sIE5vcnRo

IENhcm9saW5hOyBEaXZpc2lvbiBvZiBDYXJkaW9sb2d5LCBEZXBhcnRtZW50IG9mIE1lZGljaW5l

LCBEdWtlIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBEdXJoYW0sIE5vcnRoIENhcm9s

aW5hLiYjeEQ7R3JlZW4gTGFuZSBDYXJkaW92YXNjdWxhciBTZXJ2aWNlcyBBdWNrbGFuZCBDaXR5

IEhvc3BpdGFsLCBBdWNrbGFuZCwgTmV3IFplYWxhbmQuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGlj

aW5lIElJSSwgR29ldGhlIFVuaXZlcnNpdHksIEZyYW5rZnVydCBhbSBNYWluLCBHZXJtYW55LiYj

eEQ7RGl2aXNpb24gb2YgQ2FyZGlvbG9neSwgVW5pdmVyc2l0eSBvZiBDb2xvcmFkbyBTY2hvb2wg

b2YgTWVkaWNpbmUsIEF1cm9yYSwgQ29sb3JhZG8uJiN4RDtBc3Npc3RhbmNlIFB1YmxpcXVlLUhv

cGl0YXV4IGRlIFBhcmlzLCBIb3BpdGFsIEJpY2hhdCwgUGFyaXMgYW5kIFBhcmlzIERpZGVyb3Qg

VW5pdmVyc2l0eSwgU29yYm9ubmUgUGFyaXMgQ2l0ZSwgRkFDVCAoRnJlbmNoIEFsbGlhbmNlIGZv

ciBDYXJkaW92YXNjdWxhciBUcmlhbHMpLCBJTlNFUk0gVTExNDgsIFBhcmlzLCBGcmFuY2U7IE5h

dGlvbmFsIEhlYXJ0IGFuZCBMdW5nIEluc3RpdHV0ZSwgSW1wZXJpYWwgQ29sbGVnZSwgUm95YWwg

QnJvbXB0b24gSG9zcGl0YWwsIExvbmRvbiwgVW5pdGVkIEtpbmdkb20uPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+QWxpcm9jdW1hYiBpbiBQYXRpZW50cyBXaXRoIFBvbHl2YXNjdWxhciBE

aXNlYXNlIGFuZCBSZWNlbnQgQWN1dGUgQ29yb25hcnkgU3luZHJvbWU6IE9EWVNTRVkgT1VUQ09N

RVMgVHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBBbSBDb2xsIENhcmRpb2w8L3NlY29u

ZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+MTE2Ny0xMTc2PC9wYWdlcz48dm9sdW1lPjc0PC92

b2x1bWU+PG51bWJlcj45PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPmFjdXRlIGNvcm9uYXJ5

IHN5bmRyb21lPC9rZXl3b3JkPjxrZXl3b3JkPmFsaXJvY3VtYWI8L2tleXdvcmQ+PGtleXdvcmQ+

Y2VyZWJyb3Zhc2N1bGFyIGRpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+ZGVhdGg8L2tleXdvcmQ+

PGtleXdvcmQ+bWFqb3IgYWR2ZXJzZSBjYXJkaWFjIGV2ZW50czwva2V5d29yZD48a2V5d29yZD5w

ZXJpcGhlcmFsIGFydGVyeSBkaXNlYXNlPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXAgMzwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjE1NTgtMzU5NyAoRWxlY3Ryb25pYykmI3hEOzA3MzUtMTA5NyAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MzA4OTg2MDk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMwODk4NjA5

PC91cmw+PHVybD5odHRwczovL3BkZi5zY2llbmNlZGlyZWN0YXNzZXRzLmNvbS8yNzEwMjcvMS1z

Mi4wLVMwNzM1MTA5NzE4WDAwNDAwLzEtczIuMC1TMDczNTEwOTcxOTMzOTIxWC9tYWluLnBkZj9Y

LUFtei1TZWN1cml0eS1Ub2tlbj1BZ29KYjNKcFoybHVYMlZqRUFvYUNYVnpMV1ZoYzNRdE1TSkhN

RVVDSVFDNm1LckNhcmJsWEtRYm9DaEJrJTJGbmpUakw3dWdIMVg2ZGx2M0w3Q2Q3TGVBSWdZeW53

JTJCbXhCNHptU21hJTJGYmR3TFZNenJPYnZPbXpNdE9IazFpZWRvWkxaTXE0d01JMCUyRiUyRiUy

RiUyRiUyRiUyRiUyRiUyRiUyRiUyRiUyRkFSQUNHZ3d3TlRrd01ETTFORFk0TmpVaURFV0xWYk9U

b0ZXVlV0WHpUaXEzQTRrR3NlVG1PWGdUUndxeGN6STR3MDZtVTNwbjA0JTJGeUl3N2I3JTJCd05v

JTJCVCUyQmp4OHZRVTMybDglMkJqaXl6dENIaXQ1UFFFYmdPVHVEN0xyZDN0TGtLaWtaN2djWmRn

aHJGV29WdVRXSkRTSiUyQk5sNE13bFNRUGRqbXNaZnBvbVFITGxuZUU0clI1R3o0eERISHR5QzUx

JTJGJTJCOUkxQnJUOXkwJTJGdVhzcHE0cHhzVW1uWm1nYk5lTW5XbkM4MVZDVXQlMkI3eDVzaHJ1

TGNWbEhvamN1VzBUNk1XVWJCbml0ZnJYblhhUU8lMkI2RGVpaGw4JTJGUTJ5RXklMkZpVEpIRlls

SzhrVVFuVWhqcWlsTDdURWVOUmRucVppaXQ2RjFzU3NnU01MallNc1dqbnhSVU1UN005TWklMkJX

WW42bndHblIxZDNqSlY5ZUZBYjklMkY4VGpXem9QNFhDOE1tTmQlMkZEVFJFR1ZHJTJCQmljMUN5

d1VITHlDUTdMWVMlMkY1eHdIdyUyQjhZJTJCbHpzY1daZ2RoZTdsRmFuS2NndFo5MEpJZVJXREwz

RWJtZno3OUcxMnZORHZLdGVRMERFSmFaWkQ1OXQ4b3NRM2VhakpvR0hmaSUyQnZkS2tQTXBzYmM0

QUxHMXVmMUYlMkZJM2NWVm0lMkJVdXNYOVNlS3RTNWJxVW54eXAwUDB2NzhYczBSSjc0Sk5VM3lV

RGY5WlpyMWR4ZElqSjdvRktDRmczb3p2cjhYelRsUHhnZmN0JTJCczRmdSUyQjZEcGRwOEpzMEtU

T0p3UHp0OFd5JTJCWXRTVnZGd3k2OGhRd2hOeVg3QVU2dEFHc09yTm5PNVlLcGd1UDhLcHFDZTRO

bDVpWGJic1Fka3QlMkZMTHk1MzJ3dHpzQ0JISU1qeUZZbTNObVJjMzA5TENQUjRRbnNGcWs5REk0

Zm1TRjd6RFRuZThVMTR0eTdQMlZjeW1ZNFZzdDFnTmREUVk3MXVTMDI0WCUyQmJzR3RKaE9ZSzM0

dGVBQ0RWTlc3MllyTDNIMTYzeTc0NEkySEhQQXpoOEVxVGI1eHBGcDhRaHZLTHc2ZHV0TXZBYUJi

WUZoaHViYzZpSXROUkhxNFJSdEpheUwxcGluUENSJTJGektJUEhxVW5tcnFaU3BIVm9ybGc4JTNE

JmFtcDtYLUFtei1BbGdvcml0aG09QVdTNC1ITUFDLVNIQTI1NiZhbXA7WC1BbXotRGF0ZT0yMDE5

MDkyMVQxMDQ0MjdaJmFtcDtYLUFtei1TaWduZWRIZWFkZXJzPWhvc3QmYW1wO1gtQW16LUV4cGly

ZXM9MzAwJmFtcDtYLUFtei1DcmVkZW50aWFsPUFTSUFRM1BIQ1ZUWTZFSzVFUE4yJTJGMjAxOTA5

MjElMkZ1cy1lYXN0LTElMkZzMyUyRmF3czRfcmVxdWVzdCZhbXA7WC1BbXotU2lnbmF0dXJlPTIy

ODY5NzI3NWE1NmQyMjdmODQzYjU2MGIyYTkwYzViZTgyOTkyY2M4Y2IzMzU1MjRiZDBhZDgxZDFk

NGMzZWEmYW1wO2hhc2g9NTlkOTgwNTVlZDA0NWY3NDdlZDQ4MGE5NzEzOTk1NjEyM2Y5N2Y5MzY4

ZWI3MzEwMDE5ZWE2OTY2M2NmZjk2YiZhbXA7aG9zdD02ODA0MmM5NDM1OTEwMTNhYzJiMjQzMGE4

OWIyNzBmNmFmMmM3NmQ4ZGZkMDg2YTA3MTc2YWZlN2M3NmMyYzYxJmFtcDtwaWk9UzA3MzUxMDk3

MTkzMzkyMVgmYW1wO3RpZD1zcGRmLTYyODY4NjdlLTcyOGEtNDQzNy04NTMyLTU2Y2U2MzcxZDM1

YyZhbXA7c2lkPTEwMGNlNGZkMzlhZGM2NGEyMTRhYWEzNDdhMzg2ZmRiMTdhYmd4cnFiJmFtcDt0

eXBlPWNsaWVudDwvdXJsPjx1cmw+aHR0cHM6Ly93d3cuc2NpZW5jZWRpcmVjdC5jb20vc2NpZW5j

ZS9hcnRpY2xlL3BpaS9TMDczNTEwOTcxOTMzOTIxWD92aWElM0RpaHViPC91cmw+PC9yZWxhdGVk

LXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouamFjYy4yMDE5

LjAzLjAxMzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90

ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KdWtlbWE8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxS

ZWNOdW0+NDA3NjwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi

PjIxPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA3NjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMy

cjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDYyNjQ1Ij40MDc2PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5KdWtlbWEsIEouIFcuPC9hdXRob3I+PGF1

dGhvcj5TemFyZWssIE0uPC9hdXRob3I+PGF1dGhvcj5aaWpsc3RyYSwgTC4gRS48L2F1dGhvcj48

YXV0aG9yPmRlIFNpbHZhLCBILiBBLjwvYXV0aG9yPjxhdXRob3I+QmhhdHQsIEQuIEwuPC9hdXRo

b3I+PGF1dGhvcj5CaXR0bmVyLCBWLiBBLjwvYXV0aG9yPjxhdXRob3I+RGlheiwgUi48L2F1dGhv

cj48YXV0aG9yPkVkZWxiZXJnLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+R29vZG1hbiwgUy4gRy48

L2F1dGhvcj48YXV0aG9yPkhhbm90aW4sIEMuPC9hdXRob3I+PGF1dGhvcj5IYXJyaW5ndG9uLCBS

LiBBLjwvYXV0aG9yPjxhdXRob3I+S2FycG92LCBZLjwvYXV0aG9yPjxhdXRob3I+TW9yeXVzZWYs

IEEuPC9hdXRob3I+PGF1dGhvcj5Qb3JkeSwgUi48L2F1dGhvcj48YXV0aG9yPlByaWV0bywgSi4g

Qy48L2F1dGhvcj48YXV0aG9yPlJvZSwgTS4gVC48L2F1dGhvcj48YXV0aG9yPldoaXRlLCBILiBE

LjwvYXV0aG9yPjxhdXRob3I+WmVpaGVyLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+U2Nod2FydHos

IEcuIEcuPC9hdXRob3I+PGF1dGhvcj5TdGVnLCBQLiBHLjwvYXV0aG9yPjxhdXRob3I+T2R5c3Nl

eSBPdXRjb21lcyBDb21taXR0ZWVzPC9hdXRob3I+PGF1dGhvcj5JbnZlc3RpZ2F0b3JzLDwvYXV0

aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2Yg

Q2FyZGlvbG9neSwgTGVpZGVuIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIExlaWRlbiwgVGhl

IE5ldGhlcmxhbmRzLiBFbGVjdHJvbmljIGFkZHJlc3M6IGoudy5qdWtlbWFAbHVtYy5ubC4mI3hE

O1N0YXRlIFVuaXZlcnNpdHkgb2YgTmV3IFlvcmssIERvd25zdGF0ZSBTY2hvb2wgb2YgUHVibGlj

IEhlYWx0aCwgQnJvb2tseW4sIE5ldyBZb3JrLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5

LCBMZWlkZW4gVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciwgTGVpZGVuLCBUaGUgTmV0aGVybGFu

ZHMuJiN4RDtDbGluaWNhbCBUcmlhbHMgVW5pdCwgRmFjdWx0eSBvZiBNZWRpY2luZSwgVW5pdmVy

c2l0eSBvZiBLZWxhbml5YSwgS2VsYW5peWEsIFNyaSBMYW5rYS4mI3hEO0JyaWdoYW0gYW5kIFdv

bWVuJmFwb3M7cyBIb3NwaXRhbCBIZWFydCAmYW1wOyBWYXNjdWxhciBDZW50ZXIgYW5kIEhhcnZh

cmQgTWVkaWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0cy4mI3hEO0RpdmlzaW9uIG9m

IENhcmRpb3Zhc2N1bGFyIERpc2Vhc2UsIFVuaXZlcnNpdHkgb2YgQWxhYmFtYSBhdCBCaXJtaW5n

aGFtLCBCaXJtaW5naGFtLCBBbGFiYW1hLiYjeEQ7TGF0aW5vYW1lcmljYW4gQ2FyZGlvbG9naWNh

bCBTdHVkaWVzLCBDYXJkaW92YXNjdWxhciBJbnN0aXR1dGUgb2YgUm9zYXJpbywgUm9zYXJpbywg

QXJnZW50aW5hLiYjeEQ7U2Fub2ZpLCBCcmlkZ2V3YXRlciwgTmV3IEplcnNleS4mI3hEO0NhbmFk

aWFuIFZJR09VUiBDZW50cmUsIFVuaXZlcnNpdHkgb2YgQWxiZXJ0YSwgRWRtb250b24sIEFsYmVy

dGEsIENhbmFkYTsgU3QuIE1pY2hhZWwmYXBvcztzIEhvc3BpdGFsLCBVbml2ZXJzaXR5IG9mIFRv

cm9udG8sIFRvcm9udG8sIE9udGFyaW8sIENhbmFkYS4mI3hEO1Nhbm9maSwgUGFyaXMsIEZyYW5j

ZS4mI3hEO1N0YW5mb3JkIENlbnRlciBmb3IgQ2xpbmljYWwgUmVzZWFyY2gsIERlcGFydG1lbnQg

b2YgTWVkaWNpbmUsIFN0YW5mb3JkIFVuaXZlcnNpdHksIFN0YW5mb3JkLCBDYWxpZm9ybmlhLiYj

eEQ7UnVzc2lhbiBDYXJkaW9sb2dpY2FsIFNjaWVudGlmaWMtUHJvZHVjdGl2ZSBDb21wbGV4LCBN

b3Njb3csIFJ1c3NpYW4gRmVkZXJhdGlvbi4mI3hEO1JlZ2VuZXJvbiBQaGFybWFjZXV0aWNhbHMs

IEluYy4sIFRhcnJ5dG93biwgTmV3IFlvcmsuJiN4RDtVbml2ZXJzaXR5IG9mIENoaWxlIENsaW5p

Y2FsIEhvc3BpdGFsLCBTYW50aWFnbywgQ2hpbGUuJiN4RDtEdWtlIENsaW5pY2FsIFJlc2VhcmNo

IEluc3RpdHV0ZSwgRHVrZSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBEdXJoYW0sIE5vcnRo

IENhcm9saW5hOyBEaXZpc2lvbiBvZiBDYXJkaW9sb2d5LCBEZXBhcnRtZW50IG9mIE1lZGljaW5l

LCBEdWtlIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBEdXJoYW0sIE5vcnRoIENhcm9s

aW5hLiYjeEQ7R3JlZW4gTGFuZSBDYXJkaW92YXNjdWxhciBTZXJ2aWNlcyBBdWNrbGFuZCBDaXR5

IEhvc3BpdGFsLCBBdWNrbGFuZCwgTmV3IFplYWxhbmQuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGlj

aW5lIElJSSwgR29ldGhlIFVuaXZlcnNpdHksIEZyYW5rZnVydCBhbSBNYWluLCBHZXJtYW55LiYj

eEQ7RGl2aXNpb24gb2YgQ2FyZGlvbG9neSwgVW5pdmVyc2l0eSBvZiBDb2xvcmFkbyBTY2hvb2wg

b2YgTWVkaWNpbmUsIEF1cm9yYSwgQ29sb3JhZG8uJiN4RDtBc3Npc3RhbmNlIFB1YmxpcXVlLUhv

cGl0YXV4IGRlIFBhcmlzLCBIb3BpdGFsIEJpY2hhdCwgUGFyaXMgYW5kIFBhcmlzIERpZGVyb3Qg

VW5pdmVyc2l0eSwgU29yYm9ubmUgUGFyaXMgQ2l0ZSwgRkFDVCAoRnJlbmNoIEFsbGlhbmNlIGZv

ciBDYXJkaW92YXNjdWxhciBUcmlhbHMpLCBJTlNFUk0gVTExNDgsIFBhcmlzLCBGcmFuY2U7IE5h

dGlvbmFsIEhlYXJ0IGFuZCBMdW5nIEluc3RpdHV0ZSwgSW1wZXJpYWwgQ29sbGVnZSwgUm95YWwg

QnJvbXB0b24gSG9zcGl0YWwsIExvbmRvbiwgVW5pdGVkIEtpbmdkb20uPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+QWxpcm9jdW1hYiBpbiBQYXRpZW50cyBXaXRoIFBvbHl2YXNjdWxhciBE

aXNlYXNlIGFuZCBSZWNlbnQgQWN1dGUgQ29yb25hcnkgU3luZHJvbWU6IE9EWVNTRVkgT1VUQ09N

RVMgVHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBBbSBDb2xsIENhcmRpb2w8L3NlY29u

ZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+MTE2Ny0xMTc2PC9wYWdlcz48dm9sdW1lPjc0PC92

b2x1bWU+PG51bWJlcj45PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPmFjdXRlIGNvcm9uYXJ5

IHN5bmRyb21lPC9rZXl3b3JkPjxrZXl3b3JkPmFsaXJvY3VtYWI8L2tleXdvcmQ+PGtleXdvcmQ+

Y2VyZWJyb3Zhc2N1bGFyIGRpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+ZGVhdGg8L2tleXdvcmQ+

PGtleXdvcmQ+bWFqb3IgYWR2ZXJzZSBjYXJkaWFjIGV2ZW50czwva2V5d29yZD48a2V5d29yZD5w

ZXJpcGhlcmFsIGFydGVyeSBkaXNlYXNlPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXAgMzwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjE1NTgtMzU5NyAoRWxlY3Ryb25pYykmI3hEOzA3MzUtMTA5NyAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MzA4OTg2MDk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMwODk4NjA5

PC91cmw+PHVybD5odHRwczovL3BkZi5zY2llbmNlZGlyZWN0YXNzZXRzLmNvbS8yNzEwMjcvMS1z

Mi4wLVMwNzM1MTA5NzE4WDAwNDAwLzEtczIuMC1TMDczNTEwOTcxOTMzOTIxWC9tYWluLnBkZj9Y

LUFtei1TZWN1cml0eS1Ub2tlbj1BZ29KYjNKcFoybHVYMlZqRUFvYUNYVnpMV1ZoYzNRdE1TSkhN

RVVDSVFDNm1LckNhcmJsWEtRYm9DaEJrJTJGbmpUakw3dWdIMVg2ZGx2M0w3Q2Q3TGVBSWdZeW53

JTJCbXhCNHptU21hJTJGYmR3TFZNenJPYnZPbXpNdE9IazFpZWRvWkxaTXE0d01JMCUyRiUyRiUy

RiUyRiUyRiUyRiUyRiUyRiUyRiUyRiUyRkFSQUNHZ3d3TlRrd01ETTFORFk0TmpVaURFV0xWYk9U

b0ZXVlV0WHpUaXEzQTRrR3NlVG1PWGdUUndxeGN6STR3MDZtVTNwbjA0JTJGeUl3N2I3JTJCd05v

JTJCVCUyQmp4OHZRVTMybDglMkJqaXl6dENIaXQ1UFFFYmdPVHVEN0xyZDN0TGtLaWtaN2djWmRn

aHJGV29WdVRXSkRTSiUyQk5sNE13bFNRUGRqbXNaZnBvbVFITGxuZUU0clI1R3o0eERISHR5QzUx

JTJGJTJCOUkxQnJUOXkwJTJGdVhzcHE0cHhzVW1uWm1nYk5lTW5XbkM4MVZDVXQlMkI3eDVzaHJ1

TGNWbEhvamN1VzBUNk1XVWJCbml0ZnJYblhhUU8lMkI2RGVpaGw4JTJGUTJ5RXklMkZpVEpIRlls

SzhrVVFuVWhqcWlsTDdURWVOUmRucVppaXQ2RjFzU3NnU01MallNc1dqbnhSVU1UN005TWklMkJX

WW42bndHblIxZDNqSlY5ZUZBYjklMkY4VGpXem9QNFhDOE1tTmQlMkZEVFJFR1ZHJTJCQmljMUN5

d1VITHlDUTdMWVMlMkY1eHdIdyUyQjhZJTJCbHpzY1daZ2RoZTdsRmFuS2NndFo5MEpJZVJXREwz

RWJtZno3OUcxMnZORHZLdGVRMERFSmFaWkQ1OXQ4b3NRM2VhakpvR0hmaSUyQnZkS2tQTXBzYmM0

QUxHMXVmMUYlMkZJM2NWVm0lMkJVdXNYOVNlS3RTNWJxVW54eXAwUDB2NzhYczBSSjc0Sk5VM3lV

RGY5WlpyMWR4ZElqSjdvRktDRmczb3p2cjhYelRsUHhnZmN0JTJCczRmdSUyQjZEcGRwOEpzMEtU

T0p3UHp0OFd5JTJCWXRTVnZGd3k2OGhRd2hOeVg3QVU2dEFHc09yTm5PNVlLcGd1UDhLcHFDZTRO

bDVpWGJic1Fka3QlMkZMTHk1MzJ3dHpzQ0JISU1qeUZZbTNObVJjMzA5TENQUjRRbnNGcWs5REk0

Zm1TRjd6RFRuZThVMTR0eTdQMlZjeW1ZNFZzdDFnTmREUVk3MXVTMDI0WCUyQmJzR3RKaE9ZSzM0

dGVBQ0RWTlc3MllyTDNIMTYzeTc0NEkySEhQQXpoOEVxVGI1eHBGcDhRaHZLTHc2ZHV0TXZBYUJi

WUZoaHViYzZpSXROUkhxNFJSdEpheUwxcGluUENSJTJGektJUEhxVW5tcnFaU3BIVm9ybGc4JTNE

JmFtcDtYLUFtei1BbGdvcml0aG09QVdTNC1ITUFDLVNIQTI1NiZhbXA7WC1BbXotRGF0ZT0yMDE5

MDkyMVQxMDQ0MjdaJmFtcDtYLUFtei1TaWduZWRIZWFkZXJzPWhvc3QmYW1wO1gtQW16LUV4cGly

ZXM9MzAwJmFtcDtYLUFtei1DcmVkZW50aWFsPUFTSUFRM1BIQ1ZUWTZFSzVFUE4yJTJGMjAxOTA5

MjElMkZ1cy1lYXN0LTElMkZzMyUyRmF3czRfcmVxdWVzdCZhbXA7WC1BbXotU2lnbmF0dXJlPTIy

ODY5NzI3NWE1NmQyMjdmODQzYjU2MGIyYTkwYzViZTgyOTkyY2M4Y2IzMzU1MjRiZDBhZDgxZDFk

NGMzZWEmYW1wO2hhc2g9NTlkOTgwNTVlZDA0NWY3NDdlZDQ4MGE5NzEzOTk1NjEyM2Y5N2Y5MzY4

ZWI3MzEwMDE5ZWE2OTY2M2NmZjk2YiZhbXA7aG9zdD02ODA0MmM5NDM1OTEwMTNhYzJiMjQzMGE4

OWIyNzBmNmFmMmM3NmQ4ZGZkMDg2YTA3MTc2YWZlN2M3NmMyYzYxJmFtcDtwaWk9UzA3MzUxMDk3

MTkzMzkyMVgmYW1wO3RpZD1zcGRmLTYyODY4NjdlLTcyOGEtNDQzNy04NTMyLTU2Y2U2MzcxZDM1

YyZhbXA7c2lkPTEwMGNlNGZkMzlhZGM2NGEyMTRhYWEzNDdhMzg2ZmRiMTdhYmd4cnFiJmFtcDt0

eXBlPWNsaWVudDwvdXJsPjx1cmw+aHR0cHM6Ly93d3cuc2NpZW5jZWRpcmVjdC5jb20vc2NpZW5j

ZS9hcnRpY2xlL3BpaS9TMDczNTEwOTcxOTMzOTIxWD92aWElM0RpaHViPC91cmw+PC9yZWxhdGVk

LXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouamFjYy4yMDE5

LjAzLjAxMzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90

ZT4A

ADDIN EN.CITE.DATA 21 After a median follow-up of 2.8 years, the 1,554 patients with atherosclerotic disease in 2 or 3 vascular beds (coronary, lower limb and/or cerebrovascular) showed a significantly larger absolute risk reduction with alirocumab, as compared to patients with isolated coronary artery disease (CAD). The absolute risk reduction regarding MACE was 1.9% (95%CI -2.4–6.2%) and 13.0% (95%CI -2.0–28.0%) for two and three vascular beds, respectively, while regarding all-cause mortality was 1.3% (95%CI -1.8–4.3%) and 16.2% (95%CI 5.5–26.8%), respectively. Another pillar of the medical treatment of LEAD is optimal control of arterial hypertension.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XaWxsaWFtczwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+

PFJlY051bT40MTE1PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+NCwgMjI8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTE1PC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6

YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NzAxOTQ0MDUiPjQxMTU8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldpbGxpYW1zLCBCLjwvYXV0aG9y

PjxhdXRob3I+TWFuY2lhLCBHLjwvYXV0aG9yPjxhdXRob3I+U3BpZXJpbmcsIFcuPC9hdXRob3I+

PGF1dGhvcj5BZ2FiaXRpIFJvc2VpLCBFLjwvYXV0aG9yPjxhdXRob3I+QXppemksIE0uPC9hdXRo

b3I+PGF1dGhvcj5CdXJuaWVyLCBNLjwvYXV0aG9yPjxhdXRob3I+Q2xlbWVudCwgRC4gTC48L2F1

dGhvcj48YXV0aG9yPkNvY2EsIEEuPC9hdXRob3I+PGF1dGhvcj5kZSBTaW1vbmUsIEcuPC9hdXRo

b3I+PGF1dGhvcj5Eb21pbmljemFrLCBBLjwvYXV0aG9yPjxhdXRob3I+S2FoYW4sIFQuPC9hdXRo

b3I+PGF1dGhvcj5NYWhmb3VkLCBGLjwvYXV0aG9yPjxhdXRob3I+UmVkb24sIEouPC9hdXRob3I+

PGF1dGhvcj5SdWlsb3BlLCBMLjwvYXV0aG9yPjxhdXRob3I+WmFuY2hldHRpLCBBLjwvYXV0aG9y

PjxhdXRob3I+S2VyaW5zLCBNLjwvYXV0aG9yPjxhdXRob3I+S2plbGRzZW4sIFMuIEUuPC9hdXRo

b3I+PGF1dGhvcj5LcmV1dHosIFIuPC9hdXRob3I+PGF1dGhvcj5MYXVyZW50LCBTLjwvYXV0aG9y

PjxhdXRob3I+TGlwLCBHLiBZLiBILjwvYXV0aG9yPjxhdXRob3I+TWNNYW51cywgUi48L2F1dGhv

cj48YXV0aG9yPk5hcmtpZXdpY3osIEsuPC9hdXRob3I+PGF1dGhvcj5SdXNjaGl0emthLCBGLjwv

YXV0aG9yPjxhdXRob3I+U2NobWllZGVyLCBSLiBFLjwvYXV0aG9yPjxhdXRob3I+U2hseWFraHRv

LCBFLjwvYXV0aG9yPjxhdXRob3I+VHNpb3VmaXMsIEMuPC9hdXRob3I+PGF1dGhvcj5BYm95YW5z

LCBWLjwvYXV0aG9yPjxhdXRob3I+RGVzb3JtYWlzLCBJLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE4IEVTQy9FU0ggR3VpZGVsaW5lcyBmb3IgdGhl

IG1hbmFnZW1lbnQgb2YgYXJ0ZXJpYWwgaHlwZXJ0ZW5zaW9uPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+PHNob3J0LXRpdGxlPjIwMTggRVNDL0VT

SCBHdWlkZWxpbmVzIGZvciB0aGUgbWFuYWdlbWVudCBvZiBhcnRlcmlhbCBoeXBlcnRlbnNpb248

L3Nob3J0LXRpdGxlPjwvdGl0bGVzPjxwYWdlcz4zMDIxLTMxMDQ8L3BhZ2VzPjx2b2x1bWU+Mzk8

L3ZvbHVtZT48bnVtYmVyPjMzPC9udW1iZXI+PGVkaXRpb24+MjAxOC8wOC8zMTwvZWRpdGlvbj48

ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxkYXRlPlNlcCAxPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDE5NS02Njh4PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMwMTY1

NTE2PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9p

Lm9yZy8xMC4xMDkzL2V1cmhlYXJ0ai9laHkzMzk8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJr

LnNpbHZlcmNoYWlyLmNvbS9laHkzMzkucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hX

X0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBbXN3Z2dKbkJna3Foa2lHOXcwQkJ3YWdnZ0pZ

TUlJQ1ZBSUJBRENDQWswR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTWc1c3JX

cDdvdEZJaDBXYVFBZ0VRZ0lJQ0hua2drbFl4LU05S05LVmI5SGk5bk5FZUdXUFVnRmk3S1JTWVBU

bWRlUHMxNEtDaThPdVVtTTZhbHAxLVNRZnNRSHZ0aktJS0J4RkVDOXpOc25TMVpsNnJzMFY4WDBN

Nl9lbXJLdE53Q0hhbzFWdUN1TmhwdzRvTzZhWmt1VTRjWVlNSU9FRTFPd1kyLWtDMVkxdV9lSkJu

QlR4VUtEYzZjeG10VFppemtqRC1hakV0MTJqQzFQaDZBODVWcURScHpySE9BVER6Q0RQNkJSQ2ZV

OVcxYWhTWk5xMlVUWTVPOEIxZ01iZnpWQVI1anlFSk9MRXp2bkNDLW5GaEc0MUJ6NXJqYzZvQ2hT

aGlVUXFyQnR1Mk8zY0tISmt0UThLVkxBY05uWVExVTN2VUxKd3BVX2I3cXU2ZExJYk0wU2ZqdkJh

UVRWNjdlWXhIYkJWTERtQTdMa0tvVFBZbkl6MHd2RlFkZGR5VnRyTHBsYjJGeWt5Y1BQcFdYeXBJ

RlpOVUVmV1JKcGFSZ0NaU3FzamJKaGlWSlpUYnJrSmtLRF9IdW5vaGZvTS1sdEhaaGFfZWc2Uk5S

b1ZiY3hsSWFjeEFpVFhTZWoyVkp6Tk1CSDNKS3h0X0tpTzI0M2R4Y1JxRVZ3SGdYSEV1ZnI3VnQy

TS1TYlJHQWU0UHV6X3IzZlkxWUY0VmUtWnFOOFB2eDdfWk1ELWFybjlJXzNERGVhX1d4TmFDMTl5

ZDRON1JmZGpDWnoxOV9HUDA2TXhmTHlremk5WW9vc1I4THo0a2cyRGU4WUpUeWN0WFdYbzEzcHVn

d205RDdwdk04UFVYWGVJZy1JZnRoV0ptalVPcU9GN3dKSU9zSXN3dXFfZ1U2VUlEM3dRTkJrS0dX

bi05NUFMaUNaU2hadzdSbEZCbnJ1XzhVLTFfRXpEOWlCZVdzWE1LNDRPa0lSUUl5Zm5saUhpUGc1

blo8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjEwOTMvZXVyaGVhcnRqL2VoeTMzOTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj5ObG08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+

ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5BYm95YW5zPC9BdXRo

b3I+PFllYXI+MjAxODwvWWVhcj48UmVjTnVtPjM2MTY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjM2MTY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIy

ZWFwMDJmZmp4cHphc2VzMnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTUyNTA4NDM0

MCI+MzYxNjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QWJveWFucywg

Vi48L2F1dGhvcj48YXV0aG9yPlJpY2NvLCBKLiBCLjwvYXV0aG9yPjxhdXRob3I+QmFydGVsaW5r

LCBNLiBFLiBMLjwvYXV0aG9yPjxhdXRob3I+QmpvcmNrLCBNLjwvYXV0aG9yPjxhdXRob3I+QnJv

ZG1hbm4sIE0uPC9hdXRob3I+PGF1dGhvcj5Db2huZXJ0LCBULjwvYXV0aG9yPjxhdXRob3I+Q29s

bGV0LCBKLiBQLjwvYXV0aG9yPjxhdXRob3I+Q3plcm55LCBNLjwvYXV0aG9yPjxhdXRob3I+RGUg

Q2FybG8sIE0uPC9hdXRob3I+PGF1dGhvcj5EZWJ1cywgUy48L2F1dGhvcj48YXV0aG9yPkVzcGlu

b2xhLUtsZWluLCBDLjwvYXV0aG9yPjxhdXRob3I+S2FoYW4sIFQuPC9hdXRob3I+PGF1dGhvcj5L

b3duYXRvciwgUy48L2F1dGhvcj48YXV0aG9yPk1henpvbGFpLCBMLjwvYXV0aG9yPjxhdXRob3I+

TmF5bG9yLCBBLiBSLjwvYXV0aG9yPjxhdXRob3I+Um9mZmksIE0uPC9hdXRob3I+PGF1dGhvcj5S

b3RoZXIsIEouPC9hdXRob3I+PGF1dGhvcj5TcHJ5bmdlciwgTS48L2F1dGhvcj48YXV0aG9yPlRl

bmRlcmEsIE0uPC9hdXRob3I+PGF1dGhvcj5UZXBlLCBHLjwvYXV0aG9yPjxhdXRob3I+VmVuZXJt

bywgTS48L2F1dGhvcj48YXV0aG9yPlZsYWNob3BvdWxvcywgQy48L2F1dGhvcj48YXV0aG9yPkRl

c29ybWFpcywgSS48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIFNjaWVudGlmaWMgRG9jdW1lbnQg

R3JvdXA8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+MjAx

NyBFU0MgR3VpZGVsaW5lcyBvbiB0aGUgRGlhZ25vc2lzIGFuZCBUcmVhdG1lbnQgb2YgUGVyaXBo

ZXJhbCBBcnRlcmlhbCBEaXNlYXNlcywgaW4gY29sbGFib3JhdGlvbiB3aXRoIHRoZSBFdXJvcGVh

biBTb2NpZXR5IGZvciBWYXNjdWxhciBTdXJnZXJ5IChFU1ZTKTogRG9jdW1lbnQgY292ZXJpbmcg

YXRoZXJvc2NsZXJvdGljIGRpc2Vhc2Ugb2YgZXh0cmFjcmFuaWFsIGNhcm90aWQgYW5kIHZlcnRl

YnJhbCwgbWVzZW50ZXJpYywgcmVuYWwsIHVwcGVyIGFuZCBsb3dlciBleHRyZW1pdHkgYXJ0ZXJp

ZXNFbmRvcnNlZCBieTogdGhlIEV1cm9wZWFuIFN0cm9rZSBPcmdhbml6YXRpb24gKEVTTylUaGUg

VGFzayBGb3JjZSBmb3IgdGhlIERpYWdub3NpcyBhbmQgVHJlYXRtZW50IG9mIFBlcmlwaGVyYWwg

QXJ0ZXJpYWwgRGlzZWFzZXMgb2YgdGhlIEV1cm9wZWFuIFNvY2lldHkgb2YgQ2FyZGlvbG9neSAo

RVNDKSBhbmQgb2YgdGhlIEV1cm9wZWFuIFNvY2lldHkgZm9yIFZhc2N1bGFyIFN1cmdlcnkgKEVT

VlMpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5FdXJvcGVhbiBoZWFydCBqb3VybmFsPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBh

Z2VzPjc2My04MTY8L3BhZ2VzPjx2b2x1bWU+Mzk8L3ZvbHVtZT48bnVtYmVyPjk8L251bWJlcj48

ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1hciAxPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhY

IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yODg4NjYyMDwvYWNjZXNzaW9uLW51bT48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1l

ZC8yODg4NjYyMDwvdXJsPjx1cmw+aHR0cHM6Ly93YXRlcm1hcmsuc2lsdmVyY2hhaXIuY29tL2Vo

eDA5NS5wZGY/dG9rZW49QVFFQ0FIaTIwOEJFNDlPb2FuOWtraFdfRXJjeTdEbTNaTF85Q2YzcWZL

QWM0ODV5c2dBQUFjVXdnZ0hCQmdrcWhraUc5dzBCQndhZ2dnR3lNSUlCcmdJQkFEQ0NBYWNHQ1Nx

R1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFNRUFTNHdFUVFNYmNGenNPNXlhXzliSFJRQkFnRVFnSUlC

ZUYzZndsMTBjSDlPaWxWUVVSeWRnMkxVbU94UHZNTnBNSnVuM3RTODJlaHJwYXhGaGVxRWtYSTlv

R09RYmc0cFZYMUlqRU5teS1zTi1HdWdDcWQ3RWQzamxfNkdUQndLdWlycXRKbFo2UnNWXzRtQzhP

am9tZzhWeHBoc1VmTHFjdGxGcGdvYVVDYlQ5bEFDTG5DWGo2X2ptcG1nN2N3am9NOUpXTERMRFkx

MzZoM2NnMDA0cTdQenVvcnJWYnRCUm5jZXYzRTZYMFVxT3JOT2NfcWl2aEFIMFNlRXdUb0xfY1U0

NHZXdzNzV25IQVpUNWJ0S2pMeFptMmVlM0JpTXY0SVRiMkxNb3JKZGVvdEhUbDV2NUlqcXBSZUNo

QXI2Ny1HejRKNTVJWF9fSnRHZHVBdm5DZXdIVnJKYllVQkZXN1Fxb3JBSWxjc19fSTQ3RmEyeUJL

M1d1UDdQV20wVk5uMl8wZGx1b0xYdnNpLTRNb3U3N01kdmV1UW9qUjdkUEtPVlpNeGNUcG93YjlR

OTVBWEs3MXNOTXF4VzJIOXBwVHo3emk5N092Q2xCOTduMmVJNWpTbGZMWC1XWDRHWEhmcGJabEFy

dlFQS0tZS216UFAzcmVwSnJESjJvVy1PLXRpVmJtejJ5ZGxzOC1jOEw0R2VyaHM8L3VybD48L3Jl

bGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVh

cnRqL2VoeDA5NTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XaWxsaWFtczwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+

PFJlY051bT40MTE1PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+NCwgMjI8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTE1PC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6

YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NzAxOTQ0MDUiPjQxMTU8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldpbGxpYW1zLCBCLjwvYXV0aG9y

PjxhdXRob3I+TWFuY2lhLCBHLjwvYXV0aG9yPjxhdXRob3I+U3BpZXJpbmcsIFcuPC9hdXRob3I+

PGF1dGhvcj5BZ2FiaXRpIFJvc2VpLCBFLjwvYXV0aG9yPjxhdXRob3I+QXppemksIE0uPC9hdXRo

b3I+PGF1dGhvcj5CdXJuaWVyLCBNLjwvYXV0aG9yPjxhdXRob3I+Q2xlbWVudCwgRC4gTC48L2F1

dGhvcj48YXV0aG9yPkNvY2EsIEEuPC9hdXRob3I+PGF1dGhvcj5kZSBTaW1vbmUsIEcuPC9hdXRo

b3I+PGF1dGhvcj5Eb21pbmljemFrLCBBLjwvYXV0aG9yPjxhdXRob3I+S2FoYW4sIFQuPC9hdXRo

b3I+PGF1dGhvcj5NYWhmb3VkLCBGLjwvYXV0aG9yPjxhdXRob3I+UmVkb24sIEouPC9hdXRob3I+

PGF1dGhvcj5SdWlsb3BlLCBMLjwvYXV0aG9yPjxhdXRob3I+WmFuY2hldHRpLCBBLjwvYXV0aG9y

PjxhdXRob3I+S2VyaW5zLCBNLjwvYXV0aG9yPjxhdXRob3I+S2plbGRzZW4sIFMuIEUuPC9hdXRo

b3I+PGF1dGhvcj5LcmV1dHosIFIuPC9hdXRob3I+PGF1dGhvcj5MYXVyZW50LCBTLjwvYXV0aG9y

PjxhdXRob3I+TGlwLCBHLiBZLiBILjwvYXV0aG9yPjxhdXRob3I+TWNNYW51cywgUi48L2F1dGhv

cj48YXV0aG9yPk5hcmtpZXdpY3osIEsuPC9hdXRob3I+PGF1dGhvcj5SdXNjaGl0emthLCBGLjwv

YXV0aG9yPjxhdXRob3I+U2NobWllZGVyLCBSLiBFLjwvYXV0aG9yPjxhdXRob3I+U2hseWFraHRv

LCBFLjwvYXV0aG9yPjxhdXRob3I+VHNpb3VmaXMsIEMuPC9hdXRob3I+PGF1dGhvcj5BYm95YW5z

LCBWLjwvYXV0aG9yPjxhdXRob3I+RGVzb3JtYWlzLCBJLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE4IEVTQy9FU0ggR3VpZGVsaW5lcyBmb3IgdGhl

IG1hbmFnZW1lbnQgb2YgYXJ0ZXJpYWwgaHlwZXJ0ZW5zaW9uPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+PHNob3J0LXRpdGxlPjIwMTggRVNDL0VT

SCBHdWlkZWxpbmVzIGZvciB0aGUgbWFuYWdlbWVudCBvZiBhcnRlcmlhbCBoeXBlcnRlbnNpb248

L3Nob3J0LXRpdGxlPjwvdGl0bGVzPjxwYWdlcz4zMDIxLTMxMDQ8L3BhZ2VzPjx2b2x1bWU+Mzk8

L3ZvbHVtZT48bnVtYmVyPjMzPC9udW1iZXI+PGVkaXRpb24+MjAxOC8wOC8zMTwvZWRpdGlvbj48

ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxkYXRlPlNlcCAxPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDE5NS02Njh4PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMwMTY1

NTE2PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9p

Lm9yZy8xMC4xMDkzL2V1cmhlYXJ0ai9laHkzMzk8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJr

LnNpbHZlcmNoYWlyLmNvbS9laHkzMzkucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hX

X0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBbXN3Z2dKbkJna3Foa2lHOXcwQkJ3YWdnZ0pZ

TUlJQ1ZBSUJBRENDQWswR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTWc1c3JX

cDdvdEZJaDBXYVFBZ0VRZ0lJQ0hua2drbFl4LU05S05LVmI5SGk5bk5FZUdXUFVnRmk3S1JTWVBU

bWRlUHMxNEtDaThPdVVtTTZhbHAxLVNRZnNRSHZ0aktJS0J4RkVDOXpOc25TMVpsNnJzMFY4WDBN

Nl9lbXJLdE53Q0hhbzFWdUN1TmhwdzRvTzZhWmt1VTRjWVlNSU9FRTFPd1kyLWtDMVkxdV9lSkJu

QlR4VUtEYzZjeG10VFppemtqRC1hakV0MTJqQzFQaDZBODVWcURScHpySE9BVER6Q0RQNkJSQ2ZV

OVcxYWhTWk5xMlVUWTVPOEIxZ01iZnpWQVI1anlFSk9MRXp2bkNDLW5GaEc0MUJ6NXJqYzZvQ2hT

aGlVUXFyQnR1Mk8zY0tISmt0UThLVkxBY05uWVExVTN2VUxKd3BVX2I3cXU2ZExJYk0wU2ZqdkJh

UVRWNjdlWXhIYkJWTERtQTdMa0tvVFBZbkl6MHd2RlFkZGR5VnRyTHBsYjJGeWt5Y1BQcFdYeXBJ

RlpOVUVmV1JKcGFSZ0NaU3FzamJKaGlWSlpUYnJrSmtLRF9IdW5vaGZvTS1sdEhaaGFfZWc2Uk5S

b1ZiY3hsSWFjeEFpVFhTZWoyVkp6Tk1CSDNKS3h0X0tpTzI0M2R4Y1JxRVZ3SGdYSEV1ZnI3VnQy

TS1TYlJHQWU0UHV6X3IzZlkxWUY0VmUtWnFOOFB2eDdfWk1ELWFybjlJXzNERGVhX1d4TmFDMTl5

ZDRON1JmZGpDWnoxOV9HUDA2TXhmTHlremk5WW9vc1I4THo0a2cyRGU4WUpUeWN0WFdYbzEzcHVn

d205RDdwdk04UFVYWGVJZy1JZnRoV0ptalVPcU9GN3dKSU9zSXN3dXFfZ1U2VUlEM3dRTkJrS0dX

bi05NUFMaUNaU2hadzdSbEZCbnJ1XzhVLTFfRXpEOWlCZVdzWE1LNDRPa0lSUUl5Zm5saUhpUGc1

blo8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjEwOTMvZXVyaGVhcnRqL2VoeTMzOTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj5ObG08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+

ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5BYm95YW5zPC9BdXRo

b3I+PFllYXI+MjAxODwvWWVhcj48UmVjTnVtPjM2MTY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjM2MTY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIy

ZWFwMDJmZmp4cHphc2VzMnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTUyNTA4NDM0

MCI+MzYxNjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QWJveWFucywg

Vi48L2F1dGhvcj48YXV0aG9yPlJpY2NvLCBKLiBCLjwvYXV0aG9yPjxhdXRob3I+QmFydGVsaW5r

LCBNLiBFLiBMLjwvYXV0aG9yPjxhdXRob3I+QmpvcmNrLCBNLjwvYXV0aG9yPjxhdXRob3I+QnJv

ZG1hbm4sIE0uPC9hdXRob3I+PGF1dGhvcj5Db2huZXJ0LCBULjwvYXV0aG9yPjxhdXRob3I+Q29s

bGV0LCBKLiBQLjwvYXV0aG9yPjxhdXRob3I+Q3plcm55LCBNLjwvYXV0aG9yPjxhdXRob3I+RGUg

Q2FybG8sIE0uPC9hdXRob3I+PGF1dGhvcj5EZWJ1cywgUy48L2F1dGhvcj48YXV0aG9yPkVzcGlu

b2xhLUtsZWluLCBDLjwvYXV0aG9yPjxhdXRob3I+S2FoYW4sIFQuPC9hdXRob3I+PGF1dGhvcj5L

b3duYXRvciwgUy48L2F1dGhvcj48YXV0aG9yPk1henpvbGFpLCBMLjwvYXV0aG9yPjxhdXRob3I+

TmF5bG9yLCBBLiBSLjwvYXV0aG9yPjxhdXRob3I+Um9mZmksIE0uPC9hdXRob3I+PGF1dGhvcj5S

b3RoZXIsIEouPC9hdXRob3I+PGF1dGhvcj5TcHJ5bmdlciwgTS48L2F1dGhvcj48YXV0aG9yPlRl

bmRlcmEsIE0uPC9hdXRob3I+PGF1dGhvcj5UZXBlLCBHLjwvYXV0aG9yPjxhdXRob3I+VmVuZXJt

bywgTS48L2F1dGhvcj48YXV0aG9yPlZsYWNob3BvdWxvcywgQy48L2F1dGhvcj48YXV0aG9yPkRl

c29ybWFpcywgSS48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIFNjaWVudGlmaWMgRG9jdW1lbnQg

R3JvdXA8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+MjAx

NyBFU0MgR3VpZGVsaW5lcyBvbiB0aGUgRGlhZ25vc2lzIGFuZCBUcmVhdG1lbnQgb2YgUGVyaXBo

ZXJhbCBBcnRlcmlhbCBEaXNlYXNlcywgaW4gY29sbGFib3JhdGlvbiB3aXRoIHRoZSBFdXJvcGVh

biBTb2NpZXR5IGZvciBWYXNjdWxhciBTdXJnZXJ5IChFU1ZTKTogRG9jdW1lbnQgY292ZXJpbmcg

YXRoZXJvc2NsZXJvdGljIGRpc2Vhc2Ugb2YgZXh0cmFjcmFuaWFsIGNhcm90aWQgYW5kIHZlcnRl

YnJhbCwgbWVzZW50ZXJpYywgcmVuYWwsIHVwcGVyIGFuZCBsb3dlciBleHRyZW1pdHkgYXJ0ZXJp

ZXNFbmRvcnNlZCBieTogdGhlIEV1cm9wZWFuIFN0cm9rZSBPcmdhbml6YXRpb24gKEVTTylUaGUg

VGFzayBGb3JjZSBmb3IgdGhlIERpYWdub3NpcyBhbmQgVHJlYXRtZW50IG9mIFBlcmlwaGVyYWwg

QXJ0ZXJpYWwgRGlzZWFzZXMgb2YgdGhlIEV1cm9wZWFuIFNvY2lldHkgb2YgQ2FyZGlvbG9neSAo

RVNDKSBhbmQgb2YgdGhlIEV1cm9wZWFuIFNvY2lldHkgZm9yIFZhc2N1bGFyIFN1cmdlcnkgKEVT

VlMpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5FdXJvcGVhbiBoZWFydCBqb3VybmFsPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBh

Z2VzPjc2My04MTY8L3BhZ2VzPjx2b2x1bWU+Mzk8L3ZvbHVtZT48bnVtYmVyPjk8L251bWJlcj48

ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1hciAxPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhY

IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yODg4NjYyMDwvYWNjZXNzaW9uLW51bT48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1l

ZC8yODg4NjYyMDwvdXJsPjx1cmw+aHR0cHM6Ly93YXRlcm1hcmsuc2lsdmVyY2hhaXIuY29tL2Vo

eDA5NS5wZGY/dG9rZW49QVFFQ0FIaTIwOEJFNDlPb2FuOWtraFdfRXJjeTdEbTNaTF85Q2YzcWZL

QWM0ODV5c2dBQUFjVXdnZ0hCQmdrcWhraUc5dzBCQndhZ2dnR3lNSUlCcmdJQkFEQ0NBYWNHQ1Nx

R1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFNRUFTNHdFUVFNYmNGenNPNXlhXzliSFJRQkFnRVFnSUlC

ZUYzZndsMTBjSDlPaWxWUVVSeWRnMkxVbU94UHZNTnBNSnVuM3RTODJlaHJwYXhGaGVxRWtYSTlv

R09RYmc0cFZYMUlqRU5teS1zTi1HdWdDcWQ3RWQzamxfNkdUQndLdWlycXRKbFo2UnNWXzRtQzhP

am9tZzhWeHBoc1VmTHFjdGxGcGdvYVVDYlQ5bEFDTG5DWGo2X2ptcG1nN2N3am9NOUpXTERMRFkx

MzZoM2NnMDA0cTdQenVvcnJWYnRCUm5jZXYzRTZYMFVxT3JOT2NfcWl2aEFIMFNlRXdUb0xfY1U0

NHZXdzNzV25IQVpUNWJ0S2pMeFptMmVlM0JpTXY0SVRiMkxNb3JKZGVvdEhUbDV2NUlqcXBSZUNo

QXI2Ny1HejRKNTVJWF9fSnRHZHVBdm5DZXdIVnJKYllVQkZXN1Fxb3JBSWxjc19fSTQ3RmEyeUJL

M1d1UDdQV20wVk5uMl8wZGx1b0xYdnNpLTRNb3U3N01kdmV1UW9qUjdkUEtPVlpNeGNUcG93YjlR

OTVBWEs3MXNOTXF4VzJIOXBwVHo3emk5N092Q2xCOTduMmVJNWpTbGZMWC1XWDRHWEhmcGJabEFy

dlFQS0tZS216UFAzcmVwSnJESjJvVy1PLXRpVmJtejJ5ZGxzOC1jOEw0R2VyaHM8L3VybD48L3Jl

bGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVh

cnRqL2VoeDA5NTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT4A

ADDIN EN.CITE.DATA 4, 22 A recent analysis from the Atherosclerosis Risk in Communities (ARIC) study evaluated the impact of different stages of hypertension on the development of LEAD. ADDIN EN.CITE <EndNote><Cite><Author>Lu</Author><Year>2019</Year><RecNum>4116</RecNum><DisplayText><style face="superscript">23</style></DisplayText><record><rec-number>4116</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1570194405">4116</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lu, Y.</author><author>Ballew, S. H.</author><author>Tanaka, H.</author><author>Szklo, M.</author><author>Heiss, G.</author><author>Coresh, J.</author><author>Matsushita, K.</author></authors></contributors><auth-address>1 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. 2 Department of Kinesiology and Health Education, University of Texas at Austin, USA. 3 Department of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, USA.</auth-address><titles><title>2017 ACC/AHA blood pressure classification and incident peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study</title><secondary-title>Eur J Prev Cardiol</secondary-title><short-title>2017 ACC/AHA blood pressure classification and incident peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study</short-title></titles><pages>2047487319865378</pages><edition>2019/08/01</edition><keywords><keyword>Blood pressure</keyword><keyword>critical limb ischemia</keyword><keyword>peripheral artery disease</keyword></keywords><dates><year>2019</year><pub-dates><date>Jul 30</date></pub-dates></dates><isbn>2047-4873</isbn><accession-num>31362534</accession-num><urls></urls><electronic-resource-num>10.1177/2047487319865378</electronic-resource-num><remote-database-provider>Nlm</remote-database-provider><language>eng</language></record></Cite></EndNote>23 During a median follow-up of 25.4 years, a systolic blood pressure (BP) ≥140 mmHg or diastolic BP ≥90 mmHg was associated with higher rate of incident LEAD diagnosis (HR 2.40; 95%CI 1.72–3.34), independent of the use of anti-hypertensive medications. Higher BP categories showed significant associations with incident LEAD starting from 120-129 mmHg for systolic BP and ≥90mmHg for diastolic BP. These data emphasise the need for BP control to prevent the development of LEAD.While supervised exercise training is a mainstay of the management of claudication,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYm95YW5zPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48

UmVjTnVtPjM2MTY8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij40PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MzYxNjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMy

cjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTI1MDg0MzQwIj4zNjE2PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BYm95YW5zLCBWLjwvYXV0aG9yPjxhdXRo

b3I+UmljY28sIEouIEIuPC9hdXRob3I+PGF1dGhvcj5CYXJ0ZWxpbmssIE0uIEUuIEwuPC9hdXRo

b3I+PGF1dGhvcj5Cam9yY2ssIE0uPC9hdXRob3I+PGF1dGhvcj5Ccm9kbWFubiwgTS48L2F1dGhv

cj48YXV0aG9yPkNvaG5lcnQsIFQuPC9hdXRob3I+PGF1dGhvcj5Db2xsZXQsIEouIFAuPC9hdXRo

b3I+PGF1dGhvcj5DemVybnksIE0uPC9hdXRob3I+PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhv

cj48YXV0aG9yPkRlYnVzLCBTLjwvYXV0aG9yPjxhdXRob3I+RXNwaW5vbGEtS2xlaW4sIEMuPC9h

dXRob3I+PGF1dGhvcj5LYWhhbiwgVC48L2F1dGhvcj48YXV0aG9yPktvd25hdG9yLCBTLjwvYXV0

aG9yPjxhdXRob3I+TWF6em9sYWksIEwuPC9hdXRob3I+PGF1dGhvcj5OYXlsb3IsIEEuIFIuPC9h

dXRob3I+PGF1dGhvcj5Sb2ZmaSwgTS48L2F1dGhvcj48YXV0aG9yPlJvdGhlciwgSi48L2F1dGhv

cj48YXV0aG9yPlNwcnluZ2VyLCBNLjwvYXV0aG9yPjxhdXRob3I+VGVuZGVyYSwgTS48L2F1dGhv

cj48YXV0aG9yPlRlcGUsIEcuPC9hdXRob3I+PGF1dGhvcj5WZW5lcm1vLCBNLjwvYXV0aG9yPjxh

dXRob3I+VmxhY2hvcG91bG9zLCBDLjwvYXV0aG9yPjxhdXRob3I+RGVzb3JtYWlzLCBJLjwvYXV0

aG9yPjxhdXRob3I+RS4gUy4gQy4gU2NpZW50aWZpYyBEb2N1bWVudCBHcm91cDwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE3IEVTQyBHdWlkZWxpbmVz

IG9uIHRoZSBEaWFnbm9zaXMgYW5kIFRyZWF0bWVudCBvZiBQZXJpcGhlcmFsIEFydGVyaWFsIERp

c2Vhc2VzLCBpbiBjb2xsYWJvcmF0aW9uIHdpdGggdGhlIEV1cm9wZWFuIFNvY2lldHkgZm9yIFZh

c2N1bGFyIFN1cmdlcnkgKEVTVlMpOiBEb2N1bWVudCBjb3ZlcmluZyBhdGhlcm9zY2xlcm90aWMg

ZGlzZWFzZSBvZiBleHRyYWNyYW5pYWwgY2Fyb3RpZCBhbmQgdmVydGVicmFsLCBtZXNlbnRlcmlj

LCByZW5hbCwgdXBwZXIgYW5kIGxvd2VyIGV4dHJlbWl0eSBhcnRlcmllc0VuZG9yc2VkIGJ5OiB0

aGUgRXVyb3BlYW4gU3Ryb2tlIE9yZ2FuaXphdGlvbiAoRVNPKVRoZSBUYXNrIEZvcmNlIGZvciB0

aGUgRGlhZ25vc2lzIGFuZCBUcmVhdG1lbnQgb2YgUGVyaXBoZXJhbCBBcnRlcmlhbCBEaXNlYXNl

cyBvZiB0aGUgRXVyb3BlYW4gU29jaWV0eSBvZiBDYXJkaW9sb2d5IChFU0MpIGFuZCBvZiB0aGUg

RXVyb3BlYW4gU29jaWV0eSBmb3IgVmFzY3VsYXIgU3VyZ2VyeSAoRVNWUyk8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1cm9w

ZWFuIGhlYXJ0IGpvdXJuYWw8L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+NzYzLTgxNjwvcGFn

ZXM+PHZvbHVtZT4zOTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE4

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48

aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjI4ODg2NjIwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI4ODg2NjIwPC91cmw+

PHVybD5odHRwczovL3dhdGVybWFyay5zaWx2ZXJjaGFpci5jb20vZWh4MDk1LnBkZj90b2tlbj1B

UUVDQUhpMjA4QkU0OU9vYW45a2toV19FcmN5N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQWNVd2dn

SEJCZ2txaGtpRzl3MEJCd2FnZ2dHeU1JSUJyZ0lCQURDQ0FhY0dDU3FHU0liM0RRRUhBVEFlQmds

Z2hrZ0JaUU1FQVM0d0VRUU1iY0Z6c081eWFfOWJIUlFCQWdFUWdJSUJlRjNmd2wxMGNIOU9pbFZR

VVJ5ZGcyTFVtT3hQdk1OcE1KdW4zdFM4MmVocnBheEZoZXFFa1hJOW9HT1FiZzRwVlgxSWpFTm15

LXNOLUd1Z0NxZDdFZDNqbF82R1RCd0t1aXJxdEpsWjZSc1ZfNG1DOE9qb21nOFZ4cGhzVWZMcWN0

bEZwZ29hVUNiVDlsQUNMbkNYajZfam1wbWc3Y3dqb005SldMRExEWTEzNmgzY2cwMDRxN1B6dW9y

clZidEJSbmNldjNFNlgwVXFPck5PY19xaXZoQUgwU2VFd1RvTF9jVTQ0dld3M3NXbkhBWlQ1YnRL

akx4Wm0yZWUzQmlNdjRJVGIyTE1vckpkZW90SFRsNXY1SWpxcFJlQ2hBcjY3LUd6NEo1NUlYX19K

dEdkdUF2bkNld0hWckpiWVVCRlc3UXFvckFJbGNzX19JNDdGYTJ5QkszV3VQN1BXbTBWTm4yXzBk

bHVvTFh2c2ktNE1vdTc3TWR2ZXVRb2pSN2RQS09WWk14Y1Rwb3diOVE5NUFYSzcxc05NcXhXMkg5

cHBUejd6aTk3T3ZDbEI5N24yZUk1alNsZkxYLVdYNEdYSGZwYlpsQXJ2UVBLS1lLbXpQUDNyZXBK

ckRKMm9XLU8tdGlWYm16MnlkbHM4LWM4TDRHZXJoczwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh4MDk1PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYm95YW5zPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48

UmVjTnVtPjM2MTY8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij40PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MzYxNjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMy

cjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTI1MDg0MzQwIj4zNjE2PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BYm95YW5zLCBWLjwvYXV0aG9yPjxhdXRo

b3I+UmljY28sIEouIEIuPC9hdXRob3I+PGF1dGhvcj5CYXJ0ZWxpbmssIE0uIEUuIEwuPC9hdXRo

b3I+PGF1dGhvcj5Cam9yY2ssIE0uPC9hdXRob3I+PGF1dGhvcj5Ccm9kbWFubiwgTS48L2F1dGhv

cj48YXV0aG9yPkNvaG5lcnQsIFQuPC9hdXRob3I+PGF1dGhvcj5Db2xsZXQsIEouIFAuPC9hdXRo

b3I+PGF1dGhvcj5DemVybnksIE0uPC9hdXRob3I+PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhv

cj48YXV0aG9yPkRlYnVzLCBTLjwvYXV0aG9yPjxhdXRob3I+RXNwaW5vbGEtS2xlaW4sIEMuPC9h

dXRob3I+PGF1dGhvcj5LYWhhbiwgVC48L2F1dGhvcj48YXV0aG9yPktvd25hdG9yLCBTLjwvYXV0

aG9yPjxhdXRob3I+TWF6em9sYWksIEwuPC9hdXRob3I+PGF1dGhvcj5OYXlsb3IsIEEuIFIuPC9h

dXRob3I+PGF1dGhvcj5Sb2ZmaSwgTS48L2F1dGhvcj48YXV0aG9yPlJvdGhlciwgSi48L2F1dGhv

cj48YXV0aG9yPlNwcnluZ2VyLCBNLjwvYXV0aG9yPjxhdXRob3I+VGVuZGVyYSwgTS48L2F1dGhv

cj48YXV0aG9yPlRlcGUsIEcuPC9hdXRob3I+PGF1dGhvcj5WZW5lcm1vLCBNLjwvYXV0aG9yPjxh

dXRob3I+VmxhY2hvcG91bG9zLCBDLjwvYXV0aG9yPjxhdXRob3I+RGVzb3JtYWlzLCBJLjwvYXV0

aG9yPjxhdXRob3I+RS4gUy4gQy4gU2NpZW50aWZpYyBEb2N1bWVudCBHcm91cDwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE3IEVTQyBHdWlkZWxpbmVz

IG9uIHRoZSBEaWFnbm9zaXMgYW5kIFRyZWF0bWVudCBvZiBQZXJpcGhlcmFsIEFydGVyaWFsIERp

c2Vhc2VzLCBpbiBjb2xsYWJvcmF0aW9uIHdpdGggdGhlIEV1cm9wZWFuIFNvY2lldHkgZm9yIFZh

c2N1bGFyIFN1cmdlcnkgKEVTVlMpOiBEb2N1bWVudCBjb3ZlcmluZyBhdGhlcm9zY2xlcm90aWMg

ZGlzZWFzZSBvZiBleHRyYWNyYW5pYWwgY2Fyb3RpZCBhbmQgdmVydGVicmFsLCBtZXNlbnRlcmlj

LCByZW5hbCwgdXBwZXIgYW5kIGxvd2VyIGV4dHJlbWl0eSBhcnRlcmllc0VuZG9yc2VkIGJ5OiB0

aGUgRXVyb3BlYW4gU3Ryb2tlIE9yZ2FuaXphdGlvbiAoRVNPKVRoZSBUYXNrIEZvcmNlIGZvciB0

aGUgRGlhZ25vc2lzIGFuZCBUcmVhdG1lbnQgb2YgUGVyaXBoZXJhbCBBcnRlcmlhbCBEaXNlYXNl

cyBvZiB0aGUgRXVyb3BlYW4gU29jaWV0eSBvZiBDYXJkaW9sb2d5IChFU0MpIGFuZCBvZiB0aGUg

RXVyb3BlYW4gU29jaWV0eSBmb3IgVmFzY3VsYXIgU3VyZ2VyeSAoRVNWUyk8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1cm9w

ZWFuIGhlYXJ0IGpvdXJuYWw8L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+NzYzLTgxNjwvcGFn

ZXM+PHZvbHVtZT4zOTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE4

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48

aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjI4ODg2NjIwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI4ODg2NjIwPC91cmw+

PHVybD5odHRwczovL3dhdGVybWFyay5zaWx2ZXJjaGFpci5jb20vZWh4MDk1LnBkZj90b2tlbj1B

UUVDQUhpMjA4QkU0OU9vYW45a2toV19FcmN5N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQWNVd2dn

SEJCZ2txaGtpRzl3MEJCd2FnZ2dHeU1JSUJyZ0lCQURDQ0FhY0dDU3FHU0liM0RRRUhBVEFlQmds

Z2hrZ0JaUU1FQVM0d0VRUU1iY0Z6c081eWFfOWJIUlFCQWdFUWdJSUJlRjNmd2wxMGNIOU9pbFZR

VVJ5ZGcyTFVtT3hQdk1OcE1KdW4zdFM4MmVocnBheEZoZXFFa1hJOW9HT1FiZzRwVlgxSWpFTm15

LXNOLUd1Z0NxZDdFZDNqbF82R1RCd0t1aXJxdEpsWjZSc1ZfNG1DOE9qb21nOFZ4cGhzVWZMcWN0

bEZwZ29hVUNiVDlsQUNMbkNYajZfam1wbWc3Y3dqb005SldMRExEWTEzNmgzY2cwMDRxN1B6dW9y

clZidEJSbmNldjNFNlgwVXFPck5PY19xaXZoQUgwU2VFd1RvTF9jVTQ0dld3M3NXbkhBWlQ1YnRL

akx4Wm0yZWUzQmlNdjRJVGIyTE1vckpkZW90SFRsNXY1SWpxcFJlQ2hBcjY3LUd6NEo1NUlYX19K

dEdkdUF2bkNld0hWckpiWVVCRlc3UXFvckFJbGNzX19JNDdGYTJ5QkszV3VQN1BXbTBWTm4yXzBk

bHVvTFh2c2ktNE1vdTc3TWR2ZXVRb2pSN2RQS09WWk14Y1Rwb3diOVE5NUFYSzcxc05NcXhXMkg5

cHBUejd6aTk3T3ZDbEI5N24yZUk1alNsZkxYLVdYNEdYSGZwYlpsQXJ2UVBLS1lLbXpQUDNyZXBK

ckRKMm9XLU8tdGlWYm16MnlkbHM4LWM4TDRHZXJoczwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh4MDk1PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA 4 low adherence rates limit its clinical application. In a randomized study, 156 participants were allocated to supervised treadmill exercise, supervised resistance training, or oral advice about nutrition and training.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY0Rlcm1vdHQ8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFy

PjxSZWNOdW0+NDExNzwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3Jp

cHQiPjI0PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDExNzwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTcwMTk0NDA1Ij40MTE3PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NY0Rlcm1vdHQsIE0uIE0uPC9hdXRo

b3I+PGF1dGhvcj5LaWJiZSwgTS4gUi48L2F1dGhvcj48YXV0aG9yPkd1cmFsbmlrLCBKLiBNLjwv

YXV0aG9yPjxhdXRob3I+RmVycnVjY2ksIEwuPC9hdXRob3I+PGF1dGhvcj5DcmlxdWksIE0uIEgu

PC9hdXRob3I+PGF1dGhvcj5Eb21hbmNodWssIEsuPC9hdXRob3I+PGF1dGhvcj5UaWFuLCBMLjwv

YXV0aG9yPjxhdXRob3I+WmhhbywgTC48L2F1dGhvcj48YXV0aG9yPkxpLCBMLjwvYXV0aG9yPjxh

dXRob3I+UGF0ZWwsIEsuPC9hdXRob3I+PGF1dGhvcj5Qb2xvbnNreSwgVC4gUy48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz4xIERlcGFydG1lbnQgb2YgTWVk

aWNpbmUgTm9ydGh3ZXN0ZXJuIFVuaXZlcnNpdHkgRmVpbmJlcmcgU2Nob29sIG9mIE1lZGljaW5l

IENoaWNhZ28gSUwuIDIgRGVwYXJ0bWVudCBvZiBQcmV2ZW50aXZlIE1lZGljaW5lIE5vcnRod2Vz

dGVybiBVbml2ZXJzaXR5IEZlaW5iZXJnIFNjaG9vbCBvZiBNZWRpY2luZSBDaGljYWdvIElMLiAz

IERlcGFydG1lbnQgb2YgU3VyZ2VyeSBVbml2ZXJzaXR5IG9mIE5vcnRoIENhcm9saW5hIENoYXBl

bCBIaWxsIE5DLiA0IERlcGFydG1lbnQgb2YgRXBpZGVtaW9sb2d5IGFuZCBQdWJsaWMgSGVhbHRo

IFVuaXZlcnNpdHkgb2YgTWFyeWxhbmQgU2Nob29sIG9mIE1lZGljaW5lIEJhbHRpbW9yZSBNRC4g

NSBMb25naXR1ZGluYWwgU3R1ZGllcyBTZWN0aW9uIG9mIHRoZSBUcmFuc2xhdGlvbmFsIEdlcm9u

dG9sb2d5IEJyYW5jaCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcgQmFsdGltb3JlIE1ELiA2

IERlcGFydG1lbnQgb2YgRmFtaWx5IE1lZGljaW5lIGFuZCBQdWJsaWMgSGVhbHRoIFVuaXZlcnNp

dHkgb2YgQ2FsaWZvcm5pYSBTYW4gRGllZ28gTGEgSm9sbGEgQ0EuIDcgRGVwYXJ0bWVudCBvZiBC

aW9tZWRpY2FsIERhdGEgU2NpZW5jZSBTdGFuZm9yZCBVbml2ZXJzaXR5IFBhbG8gQWx0byBDQS4g

OCBVbml2ZXJzaXR5IG9mIElsbGlub2lzIENvbGxlZ2Ugb2YgTWVkaWNpbmUgYXQgQ2hpY2FnbyBJ

TC4gOSBEZXBhcnRtZW50IG9mIE1lZGljaW5lIFVuaXZlcnNpdHkgb2YgQ2hpY2FnbyBJTC48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EdXJhYmlsaXR5IG9mIEJlbmVmaXRzIEZyb20gU3Vw

ZXJ2aXNlZCBUcmVhZG1pbGwgRXhlcmNpc2UgaW4gUGVvcGxlIFdpdGggUGVyaXBoZXJhbCBBcnRl

cnkgRGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEFtIEhlYXJ0IEFzc29jPC9zZWNv

bmRhcnktdGl0bGU+PHNob3J0LXRpdGxlPkR1cmFiaWxpdHkgb2YgQmVuZWZpdHMgRnJvbSBTdXBl

cnZpc2VkIFRyZWFkbWlsbCBFeGVyY2lzZSBpbiBQZW9wbGUgV2l0aCBQZXJpcGhlcmFsIEFydGVy

eSBEaXNlYXNlPC9zaG9ydC10aXRsZT48L3RpdGxlcz48cGFnZXM+ZTAwOTM4MDwvcGFnZXM+PHZv

bHVtZT44PC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGVkaXRpb24+MjAxOC8xMi8yODwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+ZXhlcmNpc2U8L2tleXdvcmQ+PGtleXdvcmQ+ZXhlcmNp

c2UgdHJhaW5pbmc8L2tleXdvcmQ+PGtleXdvcmQ+ZnVuY3Rpb25hbCBjYXBhY2l0eSBpbXBhaXJt

ZW50PC9rZXl3b3JkPjxrZXl3b3JkPnBlcmlwaGVyYWwgYXJ0ZXJ5IGRpc2Vhc2U8L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbiA4

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MjA0Ny05OTgwPC9pc2JuPjxhY2Nlc3Np

b24tbnVtPjMwNTg3MDY2PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDU4NzA2NjwvdXJsPjx1cmw+aHR0

cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wbWMvYXJ0aWNsZXMvUE1DNjQwNTcwNS9wZGYvSkFI

My04LWUwMDkzODAucGRmPC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3Bt

Yy9hcnRpY2xlcy9QTUM2NDA1NzA1LzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9t

Mj5QTUM2NDA1NzA1PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTYxL2ph

aGEuMTE4LjAwOTM4MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj5ObG08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5n

dWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY0Rlcm1vdHQ8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFy

PjxSZWNOdW0+NDExNzwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3Jp

cHQiPjI0PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDExNzwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTcwMTk0NDA1Ij40MTE3PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NY0Rlcm1vdHQsIE0uIE0uPC9hdXRo

b3I+PGF1dGhvcj5LaWJiZSwgTS4gUi48L2F1dGhvcj48YXV0aG9yPkd1cmFsbmlrLCBKLiBNLjwv

YXV0aG9yPjxhdXRob3I+RmVycnVjY2ksIEwuPC9hdXRob3I+PGF1dGhvcj5DcmlxdWksIE0uIEgu

PC9hdXRob3I+PGF1dGhvcj5Eb21hbmNodWssIEsuPC9hdXRob3I+PGF1dGhvcj5UaWFuLCBMLjwv

YXV0aG9yPjxhdXRob3I+WmhhbywgTC48L2F1dGhvcj48YXV0aG9yPkxpLCBMLjwvYXV0aG9yPjxh

dXRob3I+UGF0ZWwsIEsuPC9hdXRob3I+PGF1dGhvcj5Qb2xvbnNreSwgVC4gUy48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz4xIERlcGFydG1lbnQgb2YgTWVk

aWNpbmUgTm9ydGh3ZXN0ZXJuIFVuaXZlcnNpdHkgRmVpbmJlcmcgU2Nob29sIG9mIE1lZGljaW5l

IENoaWNhZ28gSUwuIDIgRGVwYXJ0bWVudCBvZiBQcmV2ZW50aXZlIE1lZGljaW5lIE5vcnRod2Vz

dGVybiBVbml2ZXJzaXR5IEZlaW5iZXJnIFNjaG9vbCBvZiBNZWRpY2luZSBDaGljYWdvIElMLiAz

IERlcGFydG1lbnQgb2YgU3VyZ2VyeSBVbml2ZXJzaXR5IG9mIE5vcnRoIENhcm9saW5hIENoYXBl

bCBIaWxsIE5DLiA0IERlcGFydG1lbnQgb2YgRXBpZGVtaW9sb2d5IGFuZCBQdWJsaWMgSGVhbHRo

IFVuaXZlcnNpdHkgb2YgTWFyeWxhbmQgU2Nob29sIG9mIE1lZGljaW5lIEJhbHRpbW9yZSBNRC4g

NSBMb25naXR1ZGluYWwgU3R1ZGllcyBTZWN0aW9uIG9mIHRoZSBUcmFuc2xhdGlvbmFsIEdlcm9u

dG9sb2d5IEJyYW5jaCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcgQmFsdGltb3JlIE1ELiA2

IERlcGFydG1lbnQgb2YgRmFtaWx5IE1lZGljaW5lIGFuZCBQdWJsaWMgSGVhbHRoIFVuaXZlcnNp

dHkgb2YgQ2FsaWZvcm5pYSBTYW4gRGllZ28gTGEgSm9sbGEgQ0EuIDcgRGVwYXJ0bWVudCBvZiBC

aW9tZWRpY2FsIERhdGEgU2NpZW5jZSBTdGFuZm9yZCBVbml2ZXJzaXR5IFBhbG8gQWx0byBDQS4g

OCBVbml2ZXJzaXR5IG9mIElsbGlub2lzIENvbGxlZ2Ugb2YgTWVkaWNpbmUgYXQgQ2hpY2FnbyBJ

TC4gOSBEZXBhcnRtZW50IG9mIE1lZGljaW5lIFVuaXZlcnNpdHkgb2YgQ2hpY2FnbyBJTC48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EdXJhYmlsaXR5IG9mIEJlbmVmaXRzIEZyb20gU3Vw

ZXJ2aXNlZCBUcmVhZG1pbGwgRXhlcmNpc2UgaW4gUGVvcGxlIFdpdGggUGVyaXBoZXJhbCBBcnRl

cnkgRGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEFtIEhlYXJ0IEFzc29jPC9zZWNv

bmRhcnktdGl0bGU+PHNob3J0LXRpdGxlPkR1cmFiaWxpdHkgb2YgQmVuZWZpdHMgRnJvbSBTdXBl

cnZpc2VkIFRyZWFkbWlsbCBFeGVyY2lzZSBpbiBQZW9wbGUgV2l0aCBQZXJpcGhlcmFsIEFydGVy

eSBEaXNlYXNlPC9zaG9ydC10aXRsZT48L3RpdGxlcz48cGFnZXM+ZTAwOTM4MDwvcGFnZXM+PHZv

bHVtZT44PC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGVkaXRpb24+MjAxOC8xMi8yODwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+ZXhlcmNpc2U8L2tleXdvcmQ+PGtleXdvcmQ+ZXhlcmNp

c2UgdHJhaW5pbmc8L2tleXdvcmQ+PGtleXdvcmQ+ZnVuY3Rpb25hbCBjYXBhY2l0eSBpbXBhaXJt

ZW50PC9rZXl3b3JkPjxrZXl3b3JkPnBlcmlwaGVyYWwgYXJ0ZXJ5IGRpc2Vhc2U8L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbiA4

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MjA0Ny05OTgwPC9pc2JuPjxhY2Nlc3Np

b24tbnVtPjMwNTg3MDY2PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDU4NzA2NjwvdXJsPjx1cmw+aHR0

cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wbWMvYXJ0aWNsZXMvUE1DNjQwNTcwNS9wZGYvSkFI

My04LWUwMDkzODAucGRmPC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3Bt

Yy9hcnRpY2xlcy9QTUM2NDA1NzA1LzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9t

Mj5QTUM2NDA1NzA1PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTYxL2ph

aGEuMTE4LjAwOTM4MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj5ObG08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5n

dWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 24 After 6 months, the 6‐minute walk distance improved only in the treadmill exercise group (36.1 m, 95%CI 13.9-58.3), but at 12 months neither treadmill nor resistance significantly differed from baseline or control (walking distance: +7.5 m and +6.1 m). These results highlight the need for long-term supervised exercise programs to maintain benefits. Additionally, a systematic review of 84 studies reported that alternative training modalities (circuit exercise, low-pain and pain-free walking, resistance training, upper/lower limb ergometry and pole striding) had significantly higher adherence and completion rates versus traditional exercise training (85.5% vs. 77.6%, and 86.6% vs. 80.8%, respectively). ADDIN EN.CITE <EndNote><Cite><Author>Lin</Author><Year>2019</Year><RecNum>4118</RecNum><DisplayText><style face="superscript">25</style></DisplayText><record><rec-number>4118</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1570194405">4118</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lin, E.</author><author>Nguyen, C. H.</author><author>Thomas, S. G.</author></authors></contributors><auth-address>1 Training and Performance Laboratory, University of Toronto, Canada. 2 KITE, Toronto Rehab-University Health Network, Cardiovascular Prevention and Rehabilitation Program, Toronto, Canada.</auth-address><titles><title>Completion and adherence rates to exercise interventions in intermittent claudication: Traditional exercise versus alternative exercise - a systematic review</title><secondary-title>Eur J Prev Cardiol</secondary-title><short-title>Completion and adherence rates to exercise interventions in intermittent claudication: Traditional exercise versus alternative exercise - a systematic review</short-title></titles><pages>2047487319846997</pages><edition>2019/06/21</edition><keywords><keyword>Intermittent claudication</keyword><keyword>adherence</keyword><keyword>alternative</keyword><keyword>completion</keyword><keyword>exercise</keyword><keyword>peripheral arterial disease</keyword><keyword>systematic review</keyword><keyword>traditional</keyword></keywords><dates><year>2019</year><pub-dates><date>Jun 19</date></pub-dates></dates><isbn>2047-4873</isbn><accession-num>31216860</accession-num><urls></urls><electronic-resource-num>10.1177/2047487319846997</electronic-resource-num><remote-database-provider>Nlm</remote-database-provider><language>eng</language></record></Cite></EndNote>25 In lack of randomized controlled trials, a large gap in evidence regards the best revascularization strategy in chronic limb threatening ischaemia (CLTI). In a retrospective analysis, 16,800 patients with CLTI who had first surgical LER (36%) were compared to those with first endovascular LER (64%). ADDIN EN.CITE <EndNote><Cite><Author>Lin</Author><Year>2019</Year><RecNum>4119</RecNum><DisplayText><style face="superscript">26</style></DisplayText><record><rec-number>4119</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1570194405">4119</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lin, J. H.</author><author>Brunson, A.</author><author>Romano, P. S.</author><author>Mell, M. W.</author><author>Humphries, M. D.</author></authors></contributors><auth-address>Division of Vascular Surgery (J.H.L., M.W.M., M.D.H.), University of California Davis Medical Center, Sacramento. Division of Hematology-Oncology (A.B.), University of California Davis Medical Center, Sacramento. Department of Internal Medicine (P.S.R.), University of California Davis Medical Center, Sacramento.</auth-address><titles><title>Endovascular-First Treatment Is Associated With Improved Amputation-Free Survival in Patients With Critical Limb Ischemia</title><secondary-title>Circ Cardiovasc Qual Outcomes</secondary-title><short-title>Endovascular-First Treatment Is Associated With Improved Amputation-Free Survival in Patients With Critical Limb Ischemia</short-title></titles><pages>e005273</pages><volume>12</volume><number>8</number><edition>2019/07/31</edition><keywords><keyword>aging</keyword><keyword>amputation</keyword><keyword>diabetes mellitus</keyword><keyword>heart failure</keyword><keyword>peripheral arterial disease</keyword><keyword>vascular surgical procedures</keyword></keywords><dates><year>2019</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1941-7713</isbn><accession-num>31357888</accession-num><urls></urls><custom2>PMC6668925</custom2><custom6>NIHMS1531719</custom6><electronic-resource-num>10.1161/circoutcomes.118.005273</electronic-resource-num><remote-database-provider>Nlm</remote-database-provider><language>eng</language></record></Cite></EndNote>26 The endovascular group was younger, but suffered from more co-morbidities, including renal failure (36% vs. 24%), CAD (34% vs. 32%), heart failure (19% vs. 15%), and diabetes (65% vs. 58%; all p<0.05). In a propensity-matched analysis, a surgery-first strategy was associated with worse amputation-free survival (HR 1.16, 95%CI 1.13–1.20), while an endovascular-first strategy was associated with higher re-intervention rates (HR 1.19, 95%CI 1.14–1.23) after 80 months of follow-up. Mortality was similar between groups (HR 0.94, 95%CI 0.89–1.11). These results suggest that an endovascular-first approach might be preferable regarding amputation-free survival.Several trials have shown the superiority of drug-eluting stents (DES) and drug-coated balloons (DCBs) versus plain balloon angioplasty (PTA) in patients with femoropopliteal disease.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZSBDYXJsbzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+

PFJlY051bT40MDY0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+MS0zPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA2NDwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDU4MDU2Ij40MDY0PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhvcj48

YXV0aG9yPk1henpvbGFpLCBMLjwvYXV0aG9yPjxhdXRob3I+Qm9zc29uZSwgRS48L2F1dGhvcj48

YXV0aG9yPkJyb2RtYW5uLCBNLjwvYXV0aG9yPjxhdXRob3I+TWljYXJpLCBBLjwvYXV0aG9yPjxh

dXRob3I+TXVpZXNhbiwgTS4gTC48L2F1dGhvcj48YXV0aG9yPlJpY2NvLCBKLiBCLjwvYXV0aG9y

PjxhdXRob3I+U3RhYmlsZSwgRS48L2F1dGhvcj48YXV0aG9yPkFnbmVsbGksIEcuPC9hdXRob3I+

PGF1dGhvcj5BYm95YW5zLCBWLjwvYXV0aG9yPjxhdXRob3I+RS4gUy4gQy4gV29ya2luZyBHcm91

cCBvbiBBb3J0YTwvYXV0aG9yPjxhdXRob3I+UGVyaXBoZXJhbCBWYXNjdWxhciwgRGlzZWFzZXM8

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DYXJkaWFjIENh

dGhldGVyaXphdGlvbiBMYWJvcmF0b3J5LCBDYXJkaW90aG9yYWNpYyBhbmQgVmFzY3VsYXIgRGVw

YXJ0bWVudCwgQXppZW5kYSBPc3BlZGFsaWVyby1Vbml2ZXJzaXRhcmlhIFBpc2FuYSwgdmlhIFBh

cmFkaXNhIDIsIDU2MTAwIFBpc2EsIEl0YWx5LiYjeEQ7RGVwYXJ0bWVudCBvZiBBbmdpb2xvZ3ks

IExhdXNhbm5lIFVuaXZlcnNpdHkgSG9zcGl0YWwsIFJ1ZSBkdSBCdWdub24gNDYsIDEwMTEgTGF1

c2FubmUsIFN3aXR6ZXJsYW5kLiYjeEQ7Q2FyZGlvbG9neSBEaXZpc2lvbiwgJnF1b3Q7Q2F2YSBk

ZSZhcG9zOyBUaXJyZW5pIGFuZCBBbWFsZmkgQ29hc3QmcXVvdDssIEhlYXJ0IERlcGFydG1lbnQs

IFVuaXZlcnNpdHkgSG9zcGl0YWwsIFZpYSBFbnJpY28gZGUgTWFyaW5pcywgODQwMTMgQ2F2YSBk

ZSZhcG9zOyBUaXJyZW5pIChTQSksIEl0YWx5LiYjeEQ7RGl2aXNpb24gb2YgQW5naW9sb2d5LCBN

ZWRpY2FsIFVuaXZlcnNpdHkgR3JheiwgQXVlbmJydWdnZXJwbGF0eiAxNSwgODAzNiBHcmF6LCBB

dXN0cmlhLiYjeEQ7R1ZNIENhcmUgYW5kIFJlc2VhcmNoLCBNYXJpYSBDZWNpbGlhIEhvc3BpdGFs

LCB2aWEgQ29ycmllcmEgMSwgNDgwMzMgQ290aWdub2xhIChSQSksIEl0YWx5LiYjeEQ7Q2xpbmlj

YWwgYW5kIEV4cGVyaW1lbnRhbCBTY2llbmNlcyBEZXBhcnRtZW50LCBVbml2ZXJzaXR5IG9mIEJy

ZXNjaWEsIFBpYXp6YWxlIFNwZWRhbGkgQ2l2aWxpIDEsIDI1MTIzIEJyZXNjaWEsIEl0YWx5LiYj

eEQ7RGVwYXJ0bWVudCBvZiBWYXNjdWxhciBTdXJnZXJ5LCBVbml2ZXJzaXR5IEhvc3BpdGFsIG9m

IFBvaXRpZXJzLCAyIFJ1ZSBkZSBsYSBNaWxldHJpZSwgODYwMjEgUG9pdGllcnMsIEZyYW5jZS4m

I3hEO0RpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIERlcGFydG1lbnQgb2YgQWR2YW5jZWQgQmlvbWVk

aWNhbCBTY2llbmNlcywgVW5pdmVyc2l0eSBvZiBOYXBvbGkgJnF1b3Q7RmVkZXJpY28gSUkmcXVv

dDssIENvcnNvIFVtYmVydG8gSSA0MCwgODAxMzggTmFwb2xpLCBJdGFseS4mI3hEO0ludGVybmFs

IGFuZCBDYXJkaW92YXNjdWxhciBNZWRpY2luZSAtIFN0cm9rZSBVbml0LCBVbml2ZXJzaXR5IG9m

IFBlcnVnaWEsIFZpYWxlIFplZmZlcmlubyBGYWluYSA0LCAwNjEyMyBQZXJ1Z2lhLCBJdGFseS4m

I3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgRHVwdXl0cmVuIFVuaXZlcnNpdHkgSG9zcGl0

YWwsIExpbW9nZXMsIGFuZCBJbnNlcm0gMTA5NCwgVHJvcGljYWwgTmV1cm9lcGlkZW1pb2xvZ3ks

IFVuaXZlcnNpdHkgb2YgTGltb2dlcywgMzMgUnVlIEZyYW5jb2lzIE1pdHRlcnJhbmQsIDg3MDMy

IExpbW9nZXMsIEZyYW5jZS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgeWVhciBp

biBjYXJkaW9sb2d5IDIwMTY6IHBlcmlwaGVyYWwgY2lyY3VsYXRpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+MTAy

OC0xMDMzPC9wYWdlcz48dm9sdW1lPjM4PC92b2x1bWU+PG51bWJlcj4xNDwvbnVtYmVyPjxrZXl3

b3Jkcz48a2V5d29yZD5Bb3J0aWMgRGlzZWFzZXMvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+

Q2FyZGlvdmFzY3VsYXIgQWdlbnRzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5D

YXJvdGlkIEFydGVyeSBEaXNlYXNlcy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8

L2tleXdvcmQ+PGtleXdvcmQ+TGVnL2Jsb29kIHN1cHBseTwva2V5d29yZD48a2V5d29yZD5QZXJp

cGhlcmFsIFZhc2N1bGFyIERpc2Vhc2VzLyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlJhbmRv

bWl6ZWQgQ29udHJvbGxlZCBUcmlhbHMgYXMgVG9waWM8L2tleXdvcmQ+PGtleXdvcmQ+U3RlbnRz

PC9rZXl3b3JkPjxrZXl3b3JkPlZlbm91cyBUaHJvbWJvZW1ib2xpc20vKnRoZXJhcHk8L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkFw

ciA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmlj

KSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yODA0Mzk3OTwv

YWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5u

bG0ubmloLmdvdi9wdWJtZWQvMjgwNDM5Nzk8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNp

bHZlcmNoYWlyLmNvbS9laHc2NDMucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0Vy

Y3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJ

Q2FRSUJBRENDQW1JR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTVZ0WldSQ0xx

UUdhVHVaa3pBZ0VRZ0lJQ005RncxVHFHd2F4REtQalJId01ZR215eXZyTVI3dG1zTmVRWkVaNHRY

NVhuUzBGWF9vaVk2UktJZHVrRHVWSHdDZmtUSGxPQVExV08yQ0lvNk9FX1BTaGE5cHFoNDJlalZx

bkRraXVaNVdDSE9JWENoYk9DS2xCeHhwQVNmSlNudm9DWGM1bEg4dkducGxRQXVTRUg3bTR0STdS

VmdsSXdUYUFXYzV2a2doUHNwNlVPdTU1WEhvR2l1dUt2ZFF2cHRXNTZjWGYyMWJfcEV5ejFiaTRE

LU1fX3dHdFd1djBGemxUazBxR0hFX2lwbFo2X19zcEtTeEFNLW5EUnFtS3FpNXpfQmh6ejZpUmpz

QllYbVVOX2VXbDloUy0zb2Y1TFZqN0pidW80VUZ2NWlfNUVtYm1QVnJPa0NjNzRpN0szcU8wZkVO

NGw3UEgzSmlBWlRIT2JuWV9CVUNVRlVXbWtkZkl3UXpKanZXdWtLaUtmMGFDbWppZGx4T3ZYWXdC

VElWUnc3QWk1WnpNMV85bmp0TnF3R3BicC12Rmd6UlJ0YXBKVzJrYk5oN0dQakdKamhwUXpuZlFo

dG50RE11OGxnVEtZckhTMWE3SFd0cVYyRGE1WmgzRlVmNmlvampCYS1RR0lnQzBDdmVFN1hCVVFf

bHZKQk0wUFFKRmVVZHM1eUM2bnlHQXN6aWdtOUQwOXp4YTlRREdoYVkyLVZvTkI1UlBPR09SSFVa

ZEV0U0hUTVF6Y0lTamF5c2VoUHM5VnN1X1lXTzktM001NmlfLXNvSDVmLVlLQm1HWVFKQmVxTHUw

N1ZOV0p4S2tRSFlhN0tZUHF2ekpMa2FicWd3UDBaaC10NjhmSnJzM2Z6c3cwNmhZVWdNOWZINF9y

RVhlS1p5NUw0eHNIaVo1VDlnZGdKMmRzUEVwcWxsUzBoOGcwdWdmS0dOVmo1Z1ZhSWM0YkhmdmJS

d3U4UWpHeUtod1M2YXVjczgzYTVaTjdWOVJZPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHc2NDM8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkFib3lhbnM8L0F1

dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNOdW0+NDA2MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+NDA2MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjJlYXAwMmZmanhwemFzZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDU4

MDU2Ij40MDYzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BYm95YW5z

LCBWLjwvYXV0aG9yPjxhdXRob3I+QnJhZWtrYW4sIFMuPC9hdXRob3I+PGF1dGhvcj5NYXp6b2xh

aSwgTC48L2F1dGhvcj48YXV0aG9yPlNpbGxlc2VuLCBILjwvYXV0aG9yPjxhdXRob3I+VmVuZXJt

bywgTS48L2F1dGhvcj48YXV0aG9yPkRlIENhcmxvLCBNLjwvYXV0aG9yPjxhdXRob3I+RS4gUy4g

Qy4gV29ya2luZyBHcm91cCBvbiBBb3J0YTwvYXV0aG9yPjxhdXRob3I+UGVyaXBoZXJhbCBWYXNj

dWxhciwgRGlzZWFzZXM8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk

cmVzcz5EZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIER1cHV5dHJlbiBVbml2ZXJzaXR5IEhvc3Bp

dGFsLCAyLCBNYXJ0aW4gTHV0aGVyIEtpbmcgQXZlLiwgTGltb2dlcywgRnJhbmNlLiYjeEQ7SW5z

ZXJtIDEwOTQsIExpbW9nZXMgU2Nob29sIG9mIE1lZGljaW5lLCBBdmUgRHIuIE1hcmNsYW5kLCA4

NzAyNSBMaW1vZ2VzLCBGcmFuY2UuJiN4RDtLLkcuIEplYnNlbiBUaHJvbWJvc2lzIFJlc2VhcmNo

IGFuZCBFeHBlcnRpc2UgQ2VudGVyIChUUkVDKSwgRGVwYXJ0bWVudCBvZiBDbGluaWNhbCBNZWRp

Y2luZSwgVWlUIC0gVGhlIEFyY3RpYyBVbml2ZXJzaXR5IG9mIE5vcndheSwgSGFuc2luZSBIYW5z

ZW5zIHZlZyAxOCwgOTAzNywgVHJvbXNvLCBOb3J3YXkuJiN4RDtEaXZpc2lvbiBvZiBBbmdpb2xv

Z3ksIERlcGFydG1lbnQgb2YgSGVhcnQgYW5kIFZlc3NlbCwgTGF1c2FubmUgVW5pdmVyc2l0eSBI

b3NwaXRhbCwgQ2ggZHUgTW9udC1QYWlzaWJsZSAxOCwgTGF1c2FubmUsIDEwMTEsIFN3aXR6ZXJs

YW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBWYXNjdWxhciBTdXJnZXJ5LCBSaWdzaG9zcGl0YWxldCwg

VW5pdmVyc2l0eSBvZiBDb3BlbmhhZ2VuLCBCbGVnZGFtc3ZlaiA5LCBDb3BlbmhhZ2VuLCAyMTAw

LCBEZW5tYXJrLiYjeEQ7RGVwYXJ0bWVudCBvZiBWYXNjdWxhciBTdXJnZXJ5LCBIZWxzaW5raSBV

bml2ZXJzaXR5IEhvc3BpdGFsLCBIYWFydG1hbmlua2F0dSA0LCBGSS0wMDI5MCBIZWxzaW5raSwg

RmlubGFuZC4mI3hEO0NhcmRpYWMgQ2F0aGV0ZXJpemF0aW9uIExhYm9yYXRvcnksIENhcmRpb3Ro

b3JhY2ljIGFuZCBWYXNjdWxhciBEZXBhcnRtZW50LCBBemllbmRhIE9zcGVhbGllcm8tVW5pdmVy

c2l0YXJpYSBQaXNhbmEsIHZpYSBQYXJhZGlzYSwgUGlzYSwgSXRhbHkuPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+VGhlIHllYXIgMjAxNyBpbiBjYXJkaW9sb2d5OiBhb3J0YSBhbmQgcGVy

aXBoZXJhbCBjaXJjdWxhdGlvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwv

c2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwYWdlcz43MzAtNzM4PC9wYWdlcz48dm9sdW1lPjM5

PC92b2x1bWU+PG51bWJlcj45PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5NYXIgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjItOTY0

NSAoRWxlY3Ryb25pYykmI3hEOzAxOTUtNjY4WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MjkzMDA4Njg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBz

Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI5MzAwODY4PC91cmw+PHVybD5odHRwczov

L3dhdGVybWFyay5zaWx2ZXJjaGFpci5jb20vZWh4ODAwLnBkZj90b2tlbj1BUUVDQUhpMjA4QkU0

OU9vYW45a2toV19FcmN5N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQW53d2dnSjRCZ2txaGtpRzl3

MEJCd2FnZ2dKcE1JSUNaUUlCQURDQ0FsNEdDU3FHU0liM0RRRUhBVEFlQmdsZ2hrZ0JaUU1FQVM0

d0VRUU1YU0JIcU1RdXN6MUU5WFNfQWdFUWdJSUNMMGNYUEFUVk1tVkpRQl9CYW9hSEFWeGl3aW5R

M1hnWmJBbnd2Q0QxNXN0VzlReEpWVlpuVnBBZDE1d0tVRTh5N2p4RXlXREoxQlUtaGpCTkdDZGI2

Z0M3YWpIVFRYZGZqMjVyVktTazdqSF9ZV2xTYzJPaXpHWTdYYXE4aUx3S0dVY1QxY3oxSDhpT2ow

c3htT2RJMXpabmdSUDRLUk80LUlBMENzRldHRTZXOGp1Y0dybUNrOEw5dnVRc2tpQXllM3pXc2hQ

eVpvd25ZdnJJZFVjb0I2WExEbDJpYUNoWElXS0EzOU1NWGxGeTdDQ1JzTHlOdU1hUGRkeDNkSnYt

OVFKaFpmZ2tmNXAtY29hX2dRNnVfVzhrV19LeWNsUHpkYUVseUx6UThoTV8wNTQ0eERETnBiS0Y4

Umw1aFVYakV6cU8wRy1jVXRWSjBwWDR4WFFGdzQtei1MV0hqamdEVG5MNURLckYyRTYxRmhxQ1B0

VzZSb1J0ZlppUHBfSkxKSEtIUTFaemdMS2otakp2SFNjRHctbjZnZ2tHLUJFS25OSHI1b2FRd2p0

RV9mYm5LSWNZQVQ4dTk4WTE0dkd1TVhMOUliem1ibW1wSFdHRWRUQmtkTi1fQ1R1XzBZZmJzdk9W

WG1pZndiSjY2VVE3Ykw1TzE1aWVQZy1lblZpT0hBbzRjNEtTVDBzRDhZXzVTbUZuQWlhU0tPSzZh

NUNyUXo0aWtxSk9xNmpaZ3hBeE5INzRFbFQtV3RxNGN5Q1RtZlJGMFpuMVlzS25lSmIxUi1YT0FL

cWd1dUtwd1VfUk16QlZGcER0OXh1TEVHYnBCN0tING1qNllZUzNjejhIVGgxZXhBZVZJY0tmWXZJ

NDVwTExzZlVQNHhBdG9MdXEtQVN4UlJKNjZBVVNXWEt3RW9YaGFxYUlnU2pELXM3NzBYbUR5a2Zz

d0QydVNHZ3ZZbWlBZkZoY1VMMWpYSVdjSXlQdHc5a25wLTA8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVhcnRqL2VoeDgwMDwv

ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QWJv

eWFuczwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJlY051bT40MDYyPC9SZWNOdW0+PHJlY29y

ZD48cmVjLW51bWJlcj40MDYyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9

IjE1NjkwNTgwNTYiPjQwNjI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkFib3lhbnMsIFYuPC9hdXRob3I+PGF1dGhvcj5WcnNhbG92aWMsIE0uPC9hdXRob3I+PGF1dGhv

cj5NYWRhcmljLCBKLjwvYXV0aG9yPjxhdXRob3I+TWF6em9sYWksIEwuPC9hdXRob3I+PGF1dGhv

cj5EZSBDYXJsbywgTS48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIFdvcmtpbmcgR3JvdXAgb24g

QW9ydGE8L2F1dGhvcj48YXV0aG9yPlBlcmlwaGVyYWwgVmFzY3VsYXIsIERpc2Vhc2VzPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBD

YXJkaW9sb2d5LCBEdXB1eXRyZW4gVW5pdmVyc2l0eSBIb3NwaXRhbCwgMiwgTWFydGluIEx1dGhl

ciBLaW5nIEF2ZSwgTGltb2dlcywgRnJhbmNlLiYjeEQ7UmVzZWFyY2ggVW5pdCBJTlNFUk0gMTA5

NCwgTGltb2dlcyBTY2hvb2wgb2YgTWVkaWNpbmUsIDIsIGF2ZSBNYXJjbGFuZCwgTGltb2dlcywg

RnJhbmNlLiYjeEQ7VW5pdmVyc2l0eSBvZiBaYWdyZWIgU2Nob29sIG9mIE1lZGljaW5lLCBTYWxh

dGEgMywgWmFncmViLCBDcm9hdGlhLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBTZXN0

cmUgTWlsb3NyZG5pY2UgVW5pdmVyc2l0eSBIb3NwaXRhbCBDZW50cmUsIFZpbm9ncmFkc2thIDI5

LCBaYWdyZWIsIENyb2F0aWEuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3kgYW5kIEFuZ2lv

bG9neSwgTmF0aW9uYWwgSW5zdGl0dXRlIG9mIENhcmRpb3Zhc2N1bGFyIERpc2Vhc2VzLCBQb2Qg

S3Jhc25vdSBob3Jrb3UgMSwgQnJhdGlzbGF2YSwgU2xvdmFraWEuJiN4RDtEaXZpc2lvbiBvZiBB

bmdpb2xvZ3ksIEhlYXJ0IGFuZCBWZXNzZWwgRGVwYXJ0bWVudCwgTGF1c2FubmUgVW5pdmVyc2l0

eSBIb3NwaXRhbCwgUnVlIGR1IEJ1Z25vbiA0NiwgTGF1c2FubmUsIFN3aXR6ZXJsYW5kLiYjeEQ7

Q2FyZGlhYyBDYXRoZXRlcml6YXRpb24gTGFib3JhdG9yeSwgQ2FyZGlvdGhvcmFjaWMgYW5kIFZh

c2N1bGFyIERlcGFydG1lbnQsIEF6aWVuZGEgT3NwZWRhbGllcm8tVW5pdmVyc2l0YXJpYSBQaXNh

bmEsIHZpYSBQYXJhZGlzYSAyLCBQaXNhLCBJdGFseS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0

aXRsZT5UaGUgeWVhciAyMDE4IGluIGNhcmRpb2xvZ3k6IGFvcnRhIGFuZCBwZXJpcGhlcmFsIGNp

cmN1bGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnkt

dGl0bGU+PC90aXRsZXM+PHBhZ2VzPjg3Mi04Nzk8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48

bnVtYmVyPjExPC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5NYXIgMTQ8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0

cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMwNjAy

MDA1PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDYwMjAwNTwvdXJsPjx1cmw+aHR0cHM6Ly9hY2FkZW1p

Yy5vdXAuY29tL2V1cmhlYXJ0ai9hcnRpY2xlLWFic3RyYWN0LzQwLzExLzg3Mi81MjY3NDc2P3Jl

ZGlyZWN0ZWRGcm9tPWZ1bGx0ZXh0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHk4OTk8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZSBDYXJsbzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+

PFJlY051bT40MDY0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+MS0zPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA2NDwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDU4MDU2Ij40MDY0PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EZSBDYXJsbywgTS48L2F1dGhvcj48

YXV0aG9yPk1henpvbGFpLCBMLjwvYXV0aG9yPjxhdXRob3I+Qm9zc29uZSwgRS48L2F1dGhvcj48

YXV0aG9yPkJyb2RtYW5uLCBNLjwvYXV0aG9yPjxhdXRob3I+TWljYXJpLCBBLjwvYXV0aG9yPjxh

dXRob3I+TXVpZXNhbiwgTS4gTC48L2F1dGhvcj48YXV0aG9yPlJpY2NvLCBKLiBCLjwvYXV0aG9y

PjxhdXRob3I+U3RhYmlsZSwgRS48L2F1dGhvcj48YXV0aG9yPkFnbmVsbGksIEcuPC9hdXRob3I+

PGF1dGhvcj5BYm95YW5zLCBWLjwvYXV0aG9yPjxhdXRob3I+RS4gUy4gQy4gV29ya2luZyBHcm91

cCBvbiBBb3J0YTwvYXV0aG9yPjxhdXRob3I+UGVyaXBoZXJhbCBWYXNjdWxhciwgRGlzZWFzZXM8

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DYXJkaWFjIENh

dGhldGVyaXphdGlvbiBMYWJvcmF0b3J5LCBDYXJkaW90aG9yYWNpYyBhbmQgVmFzY3VsYXIgRGVw

YXJ0bWVudCwgQXppZW5kYSBPc3BlZGFsaWVyby1Vbml2ZXJzaXRhcmlhIFBpc2FuYSwgdmlhIFBh

cmFkaXNhIDIsIDU2MTAwIFBpc2EsIEl0YWx5LiYjeEQ7RGVwYXJ0bWVudCBvZiBBbmdpb2xvZ3ks

IExhdXNhbm5lIFVuaXZlcnNpdHkgSG9zcGl0YWwsIFJ1ZSBkdSBCdWdub24gNDYsIDEwMTEgTGF1

c2FubmUsIFN3aXR6ZXJsYW5kLiYjeEQ7Q2FyZGlvbG9neSBEaXZpc2lvbiwgJnF1b3Q7Q2F2YSBk

ZSZhcG9zOyBUaXJyZW5pIGFuZCBBbWFsZmkgQ29hc3QmcXVvdDssIEhlYXJ0IERlcGFydG1lbnQs

IFVuaXZlcnNpdHkgSG9zcGl0YWwsIFZpYSBFbnJpY28gZGUgTWFyaW5pcywgODQwMTMgQ2F2YSBk

ZSZhcG9zOyBUaXJyZW5pIChTQSksIEl0YWx5LiYjeEQ7RGl2aXNpb24gb2YgQW5naW9sb2d5LCBN

ZWRpY2FsIFVuaXZlcnNpdHkgR3JheiwgQXVlbmJydWdnZXJwbGF0eiAxNSwgODAzNiBHcmF6LCBB

dXN0cmlhLiYjeEQ7R1ZNIENhcmUgYW5kIFJlc2VhcmNoLCBNYXJpYSBDZWNpbGlhIEhvc3BpdGFs

LCB2aWEgQ29ycmllcmEgMSwgNDgwMzMgQ290aWdub2xhIChSQSksIEl0YWx5LiYjeEQ7Q2xpbmlj

YWwgYW5kIEV4cGVyaW1lbnRhbCBTY2llbmNlcyBEZXBhcnRtZW50LCBVbml2ZXJzaXR5IG9mIEJy

ZXNjaWEsIFBpYXp6YWxlIFNwZWRhbGkgQ2l2aWxpIDEsIDI1MTIzIEJyZXNjaWEsIEl0YWx5LiYj

eEQ7RGVwYXJ0bWVudCBvZiBWYXNjdWxhciBTdXJnZXJ5LCBVbml2ZXJzaXR5IEhvc3BpdGFsIG9m

IFBvaXRpZXJzLCAyIFJ1ZSBkZSBsYSBNaWxldHJpZSwgODYwMjEgUG9pdGllcnMsIEZyYW5jZS4m

I3hEO0RpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIERlcGFydG1lbnQgb2YgQWR2YW5jZWQgQmlvbWVk

aWNhbCBTY2llbmNlcywgVW5pdmVyc2l0eSBvZiBOYXBvbGkgJnF1b3Q7RmVkZXJpY28gSUkmcXVv

dDssIENvcnNvIFVtYmVydG8gSSA0MCwgODAxMzggTmFwb2xpLCBJdGFseS4mI3hEO0ludGVybmFs

IGFuZCBDYXJkaW92YXNjdWxhciBNZWRpY2luZSAtIFN0cm9rZSBVbml0LCBVbml2ZXJzaXR5IG9m

IFBlcnVnaWEsIFZpYWxlIFplZmZlcmlubyBGYWluYSA0LCAwNjEyMyBQZXJ1Z2lhLCBJdGFseS4m

I3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgRHVwdXl0cmVuIFVuaXZlcnNpdHkgSG9zcGl0

YWwsIExpbW9nZXMsIGFuZCBJbnNlcm0gMTA5NCwgVHJvcGljYWwgTmV1cm9lcGlkZW1pb2xvZ3ks

IFVuaXZlcnNpdHkgb2YgTGltb2dlcywgMzMgUnVlIEZyYW5jb2lzIE1pdHRlcnJhbmQsIDg3MDMy

IExpbW9nZXMsIEZyYW5jZS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgeWVhciBp

biBjYXJkaW9sb2d5IDIwMTY6IHBlcmlwaGVyYWwgY2lyY3VsYXRpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+MTAy

OC0xMDMzPC9wYWdlcz48dm9sdW1lPjM4PC92b2x1bWU+PG51bWJlcj4xNDwvbnVtYmVyPjxrZXl3

b3Jkcz48a2V5d29yZD5Bb3J0aWMgRGlzZWFzZXMvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+

Q2FyZGlvdmFzY3VsYXIgQWdlbnRzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5D

YXJvdGlkIEFydGVyeSBEaXNlYXNlcy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8

L2tleXdvcmQ+PGtleXdvcmQ+TGVnL2Jsb29kIHN1cHBseTwva2V5d29yZD48a2V5d29yZD5QZXJp

cGhlcmFsIFZhc2N1bGFyIERpc2Vhc2VzLyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlJhbmRv

bWl6ZWQgQ29udHJvbGxlZCBUcmlhbHMgYXMgVG9waWM8L2tleXdvcmQ+PGtleXdvcmQ+U3RlbnRz

PC9rZXl3b3JkPjxrZXl3b3JkPlZlbm91cyBUaHJvbWJvZW1ib2xpc20vKnRoZXJhcHk8L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkFw

ciA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmlj

KSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yODA0Mzk3OTwv

YWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5u

bG0ubmloLmdvdi9wdWJtZWQvMjgwNDM5Nzk8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNp

bHZlcmNoYWlyLmNvbS9laHc2NDMucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0Vy

Y3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJ

Q2FRSUJBRENDQW1JR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTVZ0WldSQ0xx

UUdhVHVaa3pBZ0VRZ0lJQ005RncxVHFHd2F4REtQalJId01ZR215eXZyTVI3dG1zTmVRWkVaNHRY

NVhuUzBGWF9vaVk2UktJZHVrRHVWSHdDZmtUSGxPQVExV08yQ0lvNk9FX1BTaGE5cHFoNDJlalZx

bkRraXVaNVdDSE9JWENoYk9DS2xCeHhwQVNmSlNudm9DWGM1bEg4dkducGxRQXVTRUg3bTR0STdS

VmdsSXdUYUFXYzV2a2doUHNwNlVPdTU1WEhvR2l1dUt2ZFF2cHRXNTZjWGYyMWJfcEV5ejFiaTRE

LU1fX3dHdFd1djBGemxUazBxR0hFX2lwbFo2X19zcEtTeEFNLW5EUnFtS3FpNXpfQmh6ejZpUmpz

QllYbVVOX2VXbDloUy0zb2Y1TFZqN0pidW80VUZ2NWlfNUVtYm1QVnJPa0NjNzRpN0szcU8wZkVO

NGw3UEgzSmlBWlRIT2JuWV9CVUNVRlVXbWtkZkl3UXpKanZXdWtLaUtmMGFDbWppZGx4T3ZYWXdC

VElWUnc3QWk1WnpNMV85bmp0TnF3R3BicC12Rmd6UlJ0YXBKVzJrYk5oN0dQakdKamhwUXpuZlFo

dG50RE11OGxnVEtZckhTMWE3SFd0cVYyRGE1WmgzRlVmNmlvampCYS1RR0lnQzBDdmVFN1hCVVFf

bHZKQk0wUFFKRmVVZHM1eUM2bnlHQXN6aWdtOUQwOXp4YTlRREdoYVkyLVZvTkI1UlBPR09SSFVa

ZEV0U0hUTVF6Y0lTamF5c2VoUHM5VnN1X1lXTzktM001NmlfLXNvSDVmLVlLQm1HWVFKQmVxTHUw

N1ZOV0p4S2tRSFlhN0tZUHF2ekpMa2FicWd3UDBaaC10NjhmSnJzM2Z6c3cwNmhZVWdNOWZINF9y

RVhlS1p5NUw0eHNIaVo1VDlnZGdKMmRzUEVwcWxsUzBoOGcwdWdmS0dOVmo1Z1ZhSWM0YkhmdmJS

d3U4UWpHeUtod1M2YXVjczgzYTVaTjdWOVJZPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHc2NDM8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkFib3lhbnM8L0F1

dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNOdW0+NDA2MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+NDA2MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjJlYXAwMmZmanhwemFzZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDU4

MDU2Ij40MDYzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BYm95YW5z

LCBWLjwvYXV0aG9yPjxhdXRob3I+QnJhZWtrYW4sIFMuPC9hdXRob3I+PGF1dGhvcj5NYXp6b2xh

aSwgTC48L2F1dGhvcj48YXV0aG9yPlNpbGxlc2VuLCBILjwvYXV0aG9yPjxhdXRob3I+VmVuZXJt

bywgTS48L2F1dGhvcj48YXV0aG9yPkRlIENhcmxvLCBNLjwvYXV0aG9yPjxhdXRob3I+RS4gUy4g

Qy4gV29ya2luZyBHcm91cCBvbiBBb3J0YTwvYXV0aG9yPjxhdXRob3I+UGVyaXBoZXJhbCBWYXNj

dWxhciwgRGlzZWFzZXM8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk

cmVzcz5EZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIER1cHV5dHJlbiBVbml2ZXJzaXR5IEhvc3Bp

dGFsLCAyLCBNYXJ0aW4gTHV0aGVyIEtpbmcgQXZlLiwgTGltb2dlcywgRnJhbmNlLiYjeEQ7SW5z

ZXJtIDEwOTQsIExpbW9nZXMgU2Nob29sIG9mIE1lZGljaW5lLCBBdmUgRHIuIE1hcmNsYW5kLCA4

NzAyNSBMaW1vZ2VzLCBGcmFuY2UuJiN4RDtLLkcuIEplYnNlbiBUaHJvbWJvc2lzIFJlc2VhcmNo

IGFuZCBFeHBlcnRpc2UgQ2VudGVyIChUUkVDKSwgRGVwYXJ0bWVudCBvZiBDbGluaWNhbCBNZWRp

Y2luZSwgVWlUIC0gVGhlIEFyY3RpYyBVbml2ZXJzaXR5IG9mIE5vcndheSwgSGFuc2luZSBIYW5z

ZW5zIHZlZyAxOCwgOTAzNywgVHJvbXNvLCBOb3J3YXkuJiN4RDtEaXZpc2lvbiBvZiBBbmdpb2xv

Z3ksIERlcGFydG1lbnQgb2YgSGVhcnQgYW5kIFZlc3NlbCwgTGF1c2FubmUgVW5pdmVyc2l0eSBI

b3NwaXRhbCwgQ2ggZHUgTW9udC1QYWlzaWJsZSAxOCwgTGF1c2FubmUsIDEwMTEsIFN3aXR6ZXJs

YW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBWYXNjdWxhciBTdXJnZXJ5LCBSaWdzaG9zcGl0YWxldCwg

VW5pdmVyc2l0eSBvZiBDb3BlbmhhZ2VuLCBCbGVnZGFtc3ZlaiA5LCBDb3BlbmhhZ2VuLCAyMTAw

LCBEZW5tYXJrLiYjeEQ7RGVwYXJ0bWVudCBvZiBWYXNjdWxhciBTdXJnZXJ5LCBIZWxzaW5raSBV

bml2ZXJzaXR5IEhvc3BpdGFsLCBIYWFydG1hbmlua2F0dSA0LCBGSS0wMDI5MCBIZWxzaW5raSwg

RmlubGFuZC4mI3hEO0NhcmRpYWMgQ2F0aGV0ZXJpemF0aW9uIExhYm9yYXRvcnksIENhcmRpb3Ro

b3JhY2ljIGFuZCBWYXNjdWxhciBEZXBhcnRtZW50LCBBemllbmRhIE9zcGVhbGllcm8tVW5pdmVy

c2l0YXJpYSBQaXNhbmEsIHZpYSBQYXJhZGlzYSwgUGlzYSwgSXRhbHkuPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+VGhlIHllYXIgMjAxNyBpbiBjYXJkaW9sb2d5OiBhb3J0YSBhbmQgcGVy

aXBoZXJhbCBjaXJjdWxhdGlvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwv

c2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwYWdlcz43MzAtNzM4PC9wYWdlcz48dm9sdW1lPjM5

PC92b2x1bWU+PG51bWJlcj45PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5NYXIgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjItOTY0

NSAoRWxlY3Ryb25pYykmI3hEOzAxOTUtNjY4WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MjkzMDA4Njg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBz

Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI5MzAwODY4PC91cmw+PHVybD5odHRwczov

L3dhdGVybWFyay5zaWx2ZXJjaGFpci5jb20vZWh4ODAwLnBkZj90b2tlbj1BUUVDQUhpMjA4QkU0

OU9vYW45a2toV19FcmN5N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQW53d2dnSjRCZ2txaGtpRzl3

MEJCd2FnZ2dKcE1JSUNaUUlCQURDQ0FsNEdDU3FHU0liM0RRRUhBVEFlQmdsZ2hrZ0JaUU1FQVM0

d0VRUU1YU0JIcU1RdXN6MUU5WFNfQWdFUWdJSUNMMGNYUEFUVk1tVkpRQl9CYW9hSEFWeGl3aW5R

M1hnWmJBbnd2Q0QxNXN0VzlReEpWVlpuVnBBZDE1d0tVRTh5N2p4RXlXREoxQlUtaGpCTkdDZGI2

Z0M3YWpIVFRYZGZqMjVyVktTazdqSF9ZV2xTYzJPaXpHWTdYYXE4aUx3S0dVY1QxY3oxSDhpT2ow

c3htT2RJMXpabmdSUDRLUk80LUlBMENzRldHRTZXOGp1Y0dybUNrOEw5dnVRc2tpQXllM3pXc2hQ

eVpvd25ZdnJJZFVjb0I2WExEbDJpYUNoWElXS0EzOU1NWGxGeTdDQ1JzTHlOdU1hUGRkeDNkSnYt

OVFKaFpmZ2tmNXAtY29hX2dRNnVfVzhrV19LeWNsUHpkYUVseUx6UThoTV8wNTQ0eERETnBiS0Y4

Umw1aFVYakV6cU8wRy1jVXRWSjBwWDR4WFFGdzQtei1MV0hqamdEVG5MNURLckYyRTYxRmhxQ1B0

VzZSb1J0ZlppUHBfSkxKSEtIUTFaemdMS2otakp2SFNjRHctbjZnZ2tHLUJFS25OSHI1b2FRd2p0

RV9mYm5LSWNZQVQ4dTk4WTE0dkd1TVhMOUliem1ibW1wSFdHRWRUQmtkTi1fQ1R1XzBZZmJzdk9W

WG1pZndiSjY2VVE3Ykw1TzE1aWVQZy1lblZpT0hBbzRjNEtTVDBzRDhZXzVTbUZuQWlhU0tPSzZh

NUNyUXo0aWtxSk9xNmpaZ3hBeE5INzRFbFQtV3RxNGN5Q1RtZlJGMFpuMVlzS25lSmIxUi1YT0FL

cWd1dUtwd1VfUk16QlZGcER0OXh1TEVHYnBCN0tING1qNllZUzNjejhIVGgxZXhBZVZJY0tmWXZJ

NDVwTExzZlVQNHhBdG9MdXEtQVN4UlJKNjZBVVNXWEt3RW9YaGFxYUlnU2pELXM3NzBYbUR5a2Zz

d0QydVNHZ3ZZbWlBZkZoY1VMMWpYSVdjSXlQdHc5a25wLTA8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVhcnRqL2VoeDgwMDwv

ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QWJv

eWFuczwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJlY051bT40MDYyPC9SZWNOdW0+PHJlY29y

ZD48cmVjLW51bWJlcj40MDYyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9

IjE1NjkwNTgwNTYiPjQwNjI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkFib3lhbnMsIFYuPC9hdXRob3I+PGF1dGhvcj5WcnNhbG92aWMsIE0uPC9hdXRob3I+PGF1dGhv

cj5NYWRhcmljLCBKLjwvYXV0aG9yPjxhdXRob3I+TWF6em9sYWksIEwuPC9hdXRob3I+PGF1dGhv

cj5EZSBDYXJsbywgTS48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIFdvcmtpbmcgR3JvdXAgb24g

QW9ydGE8L2F1dGhvcj48YXV0aG9yPlBlcmlwaGVyYWwgVmFzY3VsYXIsIERpc2Vhc2VzPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBD

YXJkaW9sb2d5LCBEdXB1eXRyZW4gVW5pdmVyc2l0eSBIb3NwaXRhbCwgMiwgTWFydGluIEx1dGhl

ciBLaW5nIEF2ZSwgTGltb2dlcywgRnJhbmNlLiYjeEQ7UmVzZWFyY2ggVW5pdCBJTlNFUk0gMTA5

NCwgTGltb2dlcyBTY2hvb2wgb2YgTWVkaWNpbmUsIDIsIGF2ZSBNYXJjbGFuZCwgTGltb2dlcywg

RnJhbmNlLiYjeEQ7VW5pdmVyc2l0eSBvZiBaYWdyZWIgU2Nob29sIG9mIE1lZGljaW5lLCBTYWxh

dGEgMywgWmFncmViLCBDcm9hdGlhLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBTZXN0

cmUgTWlsb3NyZG5pY2UgVW5pdmVyc2l0eSBIb3NwaXRhbCBDZW50cmUsIFZpbm9ncmFkc2thIDI5

LCBaYWdyZWIsIENyb2F0aWEuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3kgYW5kIEFuZ2lv

bG9neSwgTmF0aW9uYWwgSW5zdGl0dXRlIG9mIENhcmRpb3Zhc2N1bGFyIERpc2Vhc2VzLCBQb2Qg

S3Jhc25vdSBob3Jrb3UgMSwgQnJhdGlzbGF2YSwgU2xvdmFraWEuJiN4RDtEaXZpc2lvbiBvZiBB

bmdpb2xvZ3ksIEhlYXJ0IGFuZCBWZXNzZWwgRGVwYXJ0bWVudCwgTGF1c2FubmUgVW5pdmVyc2l0

eSBIb3NwaXRhbCwgUnVlIGR1IEJ1Z25vbiA0NiwgTGF1c2FubmUsIFN3aXR6ZXJsYW5kLiYjeEQ7

Q2FyZGlhYyBDYXRoZXRlcml6YXRpb24gTGFib3JhdG9yeSwgQ2FyZGlvdGhvcmFjaWMgYW5kIFZh

c2N1bGFyIERlcGFydG1lbnQsIEF6aWVuZGEgT3NwZWRhbGllcm8tVW5pdmVyc2l0YXJpYSBQaXNh

bmEsIHZpYSBQYXJhZGlzYSAyLCBQaXNhLCBJdGFseS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0

aXRsZT5UaGUgeWVhciAyMDE4IGluIGNhcmRpb2xvZ3k6IGFvcnRhIGFuZCBwZXJpcGhlcmFsIGNp

cmN1bGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnkt

dGl0bGU+PC90aXRsZXM+PHBhZ2VzPjg3Mi04Nzk8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48

bnVtYmVyPjExPC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5NYXIgMTQ8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0

cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMwNjAy

MDA1PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDYwMjAwNTwvdXJsPjx1cmw+aHR0cHM6Ly9hY2FkZW1p

Yy5vdXAuY29tL2V1cmhlYXJ0ai9hcnRpY2xlLWFic3RyYWN0LzQwLzExLzg3Mi81MjY3NDc2P3Jl

ZGlyZWN0ZWRGcm9tPWZ1bGx0ZXh0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHk4OTk8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA 1-3 The 5-year results of the IN.PACT SFA trial showed the persistence of clinical benefits, with 74.5% freedom from clinically-driven target lesion revascularization with DCBs vs. 65.3% with PTA (p=0.020), although this benefit was non-significant in diabetics (70.3 vs. 64.4%, p=0.24).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYWlyZDwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MTIwPC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

Mjc8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTIwPC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NzAxOTQ0MDYiPjQxMjA8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxhaXJkLCBKLiBBLjwvYXV0aG9yPjxhdXRo

b3I+U2NobmVpZGVyLCBQLiBBLjwvYXV0aG9yPjxhdXRob3I+SmFmZiwgTS4gUi48L2F1dGhvcj48

YXV0aG9yPkJyb2RtYW5uLCBNLjwvYXV0aG9yPjxhdXRob3I+WmVsbGVyLCBULjwvYXV0aG9yPjxh

dXRob3I+TWV0emdlciwgRC4gQy48L2F1dGhvcj48YXV0aG9yPktyaXNobmFuLCBQLjwvYXV0aG9y

PjxhdXRob3I+U2NoZWluZXJ0LCBELjwvYXV0aG9yPjxhdXRob3I+TWljYXJpLCBBLjwvYXV0aG9y

PjxhdXRob3I+V2FuZywgSC48L2F1dGhvcj48YXV0aG9yPk1hc3RlcnMsIE0uPC9hdXRob3I+PGF1

dGhvcj5UZXBlLCBHLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPkFkdmVudGlzdCBIZWFydCBhbmQgVmFzY3VsYXIgSW5zdGl0dXRlLCBTdCBIZWxlbmEsIENB

IChKLkEuTC4pLiBLYWlzZXIgRm91bmRhdGlvbiBIb3NwaXRhbCwgSG9ub2x1bHUsIEhJIChQLkEu

Uy4pLiBIYXJ2YXJkIE1lZGljYWwgU2Nob29sLCBCb3N0b24sIE1BIChNLlIuSi4pLiBNZWRpY2Fs

IFVuaXZlcnNpdHksIEdyYXosIEF1c3RyaWEgKE0uQi4pLiBVbml2ZXJzaXRhZXRzLUhlcnp6ZW50

cnVtIEZyZWlidXJnLUJhZCBLcm96aW5nZW4sIEdlcm1hbnkgKFQuWi4pLiBCYWxsYWQgSGVhbHRo

IFN5c3RlbXMgQ1ZBIEhlYXJ0ICZhbXA7IFZhc2N1bGFyIEluc3RpdHV0ZSwgS2luZ3Nwb3J0LCBU

TiAoRC5DLk0uKS4gVGhlIE1vdW50IFNpbmFpIEhvc3BpdGFsLCBOZXcgWW9yaywgTlkgKFAuSy4p

LiBVbml2ZXJzaXR5IEhvc3BpdGFsIExlaXB6aWcsIEdlcm1hbnkgKEQuUy4pLiBHYXZhenplbmkg

SG9zcGl0YWwgSHVtYW5pdGFzLCBCZXJnYW1vLCBJdGFseSAoQS5NLikuIE1lZHRyb25pYyBJbmMs

IFNhbnRhIFJvc2EsIENBIChILlcuLCBNLk0uKS4gUm8gTWVkIENsaW5pYyBSb3NlbmhlaW0sIEdl

cm1hbnkgKEcuVC4pLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkxvbmctVGVybSBDbGlu

aWNhbCBFZmZlY3RpdmVuZXNzIG9mIGEgRHJ1Zy1Db2F0ZWQgQmFsbG9vbiBmb3IgdGhlIFRyZWF0

bWVudCBvZiBGZW1vcm9wb3BsaXRlYWwgTGVzaW9uczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5D

aXJjIENhcmRpb3Zhc2MgSW50ZXJ2PC9zZWNvbmRhcnktdGl0bGU+PHNob3J0LXRpdGxlPkxvbmct

VGVybSBDbGluaWNhbCBFZmZlY3RpdmVuZXNzIG9mIGEgRHJ1Zy1Db2F0ZWQgQmFsbG9vbiBmb3Ig

dGhlIFRyZWF0bWVudCBvZiBGZW1vcm9wb3BsaXRlYWwgTGVzaW9uczwvc2hvcnQtdGl0bGU+PC90

aXRsZXM+PHBhZ2VzPmUwMDc3MDI8L3BhZ2VzPjx2b2x1bWU+MTI8L3ZvbHVtZT48bnVtYmVyPjY8

L251bWJlcj48ZWRpdGlvbj4yMDE5LzA2LzE1PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5h

bmdpb3BsYXN0eTwva2V5d29yZD48a2V5d29yZD5kcnVnLWNvYXRlZCBiYWxsb29uczwva2V5d29y

ZD48a2V5d29yZD5wYWNsaXRheGVsPC9rZXl3b3JkPjxrZXl3b3JkPnBlcmlwaGVyYWwgYXJ0ZXJ5

IGRpc2Vhc2U8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHVi

LWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE5NDEtNzY0

MDwvaXNibj48YWNjZXNzaW9uLW51bT4zMTE5NTgyNTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVs

YXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wbWMvYXJ0aWNsZXMv

UE1DNjYzNjc5NS9wZGYvaGN2LTEyLWUwMDc3MDIucGRmPC91cmw+PC9yZWxhdGVkLXVybHM+PC91

cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTYxL2NpcmNpbnRlcnZlbnRpb25zLjEx

OC4wMDc3MDI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlk

ZXI+TmxtPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+

PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYWlyZDwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MTIwPC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

Mjc8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTIwPC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NzAxOTQ0MDYiPjQxMjA8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxhaXJkLCBKLiBBLjwvYXV0aG9yPjxhdXRo

b3I+U2NobmVpZGVyLCBQLiBBLjwvYXV0aG9yPjxhdXRob3I+SmFmZiwgTS4gUi48L2F1dGhvcj48

YXV0aG9yPkJyb2RtYW5uLCBNLjwvYXV0aG9yPjxhdXRob3I+WmVsbGVyLCBULjwvYXV0aG9yPjxh

dXRob3I+TWV0emdlciwgRC4gQy48L2F1dGhvcj48YXV0aG9yPktyaXNobmFuLCBQLjwvYXV0aG9y

PjxhdXRob3I+U2NoZWluZXJ0LCBELjwvYXV0aG9yPjxhdXRob3I+TWljYXJpLCBBLjwvYXV0aG9y

PjxhdXRob3I+V2FuZywgSC48L2F1dGhvcj48YXV0aG9yPk1hc3RlcnMsIE0uPC9hdXRob3I+PGF1

dGhvcj5UZXBlLCBHLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPkFkdmVudGlzdCBIZWFydCBhbmQgVmFzY3VsYXIgSW5zdGl0dXRlLCBTdCBIZWxlbmEsIENB

IChKLkEuTC4pLiBLYWlzZXIgRm91bmRhdGlvbiBIb3NwaXRhbCwgSG9ub2x1bHUsIEhJIChQLkEu

Uy4pLiBIYXJ2YXJkIE1lZGljYWwgU2Nob29sLCBCb3N0b24sIE1BIChNLlIuSi4pLiBNZWRpY2Fs

IFVuaXZlcnNpdHksIEdyYXosIEF1c3RyaWEgKE0uQi4pLiBVbml2ZXJzaXRhZXRzLUhlcnp6ZW50

cnVtIEZyZWlidXJnLUJhZCBLcm96aW5nZW4sIEdlcm1hbnkgKFQuWi4pLiBCYWxsYWQgSGVhbHRo

IFN5c3RlbXMgQ1ZBIEhlYXJ0ICZhbXA7IFZhc2N1bGFyIEluc3RpdHV0ZSwgS2luZ3Nwb3J0LCBU

TiAoRC5DLk0uKS4gVGhlIE1vdW50IFNpbmFpIEhvc3BpdGFsLCBOZXcgWW9yaywgTlkgKFAuSy4p

LiBVbml2ZXJzaXR5IEhvc3BpdGFsIExlaXB6aWcsIEdlcm1hbnkgKEQuUy4pLiBHYXZhenplbmkg

SG9zcGl0YWwgSHVtYW5pdGFzLCBCZXJnYW1vLCBJdGFseSAoQS5NLikuIE1lZHRyb25pYyBJbmMs

IFNhbnRhIFJvc2EsIENBIChILlcuLCBNLk0uKS4gUm8gTWVkIENsaW5pYyBSb3NlbmhlaW0sIEdl

cm1hbnkgKEcuVC4pLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkxvbmctVGVybSBDbGlu

aWNhbCBFZmZlY3RpdmVuZXNzIG9mIGEgRHJ1Zy1Db2F0ZWQgQmFsbG9vbiBmb3IgdGhlIFRyZWF0

bWVudCBvZiBGZW1vcm9wb3BsaXRlYWwgTGVzaW9uczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5D

aXJjIENhcmRpb3Zhc2MgSW50ZXJ2PC9zZWNvbmRhcnktdGl0bGU+PHNob3J0LXRpdGxlPkxvbmct

VGVybSBDbGluaWNhbCBFZmZlY3RpdmVuZXNzIG9mIGEgRHJ1Zy1Db2F0ZWQgQmFsbG9vbiBmb3Ig

dGhlIFRyZWF0bWVudCBvZiBGZW1vcm9wb3BsaXRlYWwgTGVzaW9uczwvc2hvcnQtdGl0bGU+PC90

aXRsZXM+PHBhZ2VzPmUwMDc3MDI8L3BhZ2VzPjx2b2x1bWU+MTI8L3ZvbHVtZT48bnVtYmVyPjY8

L251bWJlcj48ZWRpdGlvbj4yMDE5LzA2LzE1PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5h

bmdpb3BsYXN0eTwva2V5d29yZD48a2V5d29yZD5kcnVnLWNvYXRlZCBiYWxsb29uczwva2V5d29y

ZD48a2V5d29yZD5wYWNsaXRheGVsPC9rZXl3b3JkPjxrZXl3b3JkPnBlcmlwaGVyYWwgYXJ0ZXJ5

IGRpc2Vhc2U8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHVi

LWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE5NDEtNzY0

MDwvaXNibj48YWNjZXNzaW9uLW51bT4zMTE5NTgyNTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVs

YXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wbWMvYXJ0aWNsZXMv

UE1DNjYzNjc5NS9wZGYvaGN2LTEyLWUwMDc3MDIucGRmPC91cmw+PC9yZWxhdGVkLXVybHM+PC91

cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTYxL2NpcmNpbnRlcnZlbnRpb25zLjEx

OC4wMDc3MDI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlk

ZXI+TmxtPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+

PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA 27 The clinical use of paclitaxel-eluting devices was dramatically interrupted in November 2018 by the unexpected results of a meta-analysis including 28 RCTs with a total of 4,432 patients. ADDIN EN.CITE <EndNote><Cite><Author>Katsanos</Author><Year>2018</Year><RecNum>4121</RecNum><DisplayText><style face="superscript">28</style></DisplayText><record><rec-number>4121</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1570194406">4121</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Katsanos, K.</author><author>Spiliopoulos, S.</author><author>Kitrou, P.</author><author>Krokidis, M.</author><author>Karnabatidis, D.</author></authors></contributors><auth-address>1 Patras University Hospital Rion Greece. 2 Attikon University Hospital Athens Greece. 3 Cambridge University Hospitals NHS Foundation Trust Cambridge UK.</auth-address><titles><title>Risk of Death Following Application of Paclitaxel-Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</title><secondary-title>J Am Heart Assoc</secondary-title><short-title>Risk of Death Following Application of Paclitaxel-Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</short-title></titles><pages>e011245</pages><volume>7</volume><number>24</number><edition>2018/12/19</edition><keywords><keyword>*balloon angioplasty</keyword><keyword>*paclitaxel</keyword><keyword>*paclitaxel-coated balloon</keyword><keyword>*paclitaxel-eluting stent</keyword></keywords><dates><year>2018</year><pub-dates><date>Dec 18</date></pub-dates></dates><isbn>2047-9980</isbn><accession-num>30561254</accession-num><urls><related-urls><url> The study described a 2-fold increase in all-cause mortality between 2 and 5 years of follow-up with paclitaxel-eluting DES/DCBs (HR 1.93, 95%CI 1.27-2.93), and a causal link between paclitaxel dose and mortality was hypothesized. These findings raised great concern, halted enrolment in RCTs on paclitaxel-eluting devices, and prompted a worldwide call for high-quality data collection and analysis. Most recently, a confutation of the above-mentioned study came from a large analysis of German health claims data, investigating long-term mortality with paclitaxel-eluting devices from 2007 until present in 64,771 patients undergoing 107,112 endovascular procedures. ADDIN EN.CITE <EndNote><Cite><Author>Freisinger</Author><Year>2019</Year><RecNum>4122</RecNum><DisplayText><style face="superscript">29</style></DisplayText><record><rec-number>4122</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1570194406">4122</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Freisinger, E.</author><author>Koeppe, J.</author><author>Gerss, J.</author><author>Goerlich, D.</author><author>Malyar, NM.</author><author>Marschall, U.</author><author>Faldum, A.</author><author>Reinecke, H.</author></authors></contributors><titles><title>Mortality after use of paclitaxel-based devices in peripheral arteries: a real-world safety analysis</title><secondary-title>Eur Heart J</secondary-title></titles><volume>Epub ahead of print</volume><dates><year>2019</year></dates><urls></urls></record></Cite></EndNote>29 The use of paclitaxel-eluting devices was not associated with any signal of increased mortality up to 10 years of follow-up (Figure 3).Aortic diseaseA common challenge in the emergency room is to distinguish patients with symptoms suggestive of acute aortic syndrome (AAS) requiring a CT scan, from others. In a study of 839 patients attending the emergency room with suspected AAS, focused cardiac ultrasound, integrated into a strategy including clinical assessment and (for low-risk patients) D-Dimer testing, enabled the correct identification of all patients with aortic dissection (AD), although the sample size meant that the upper border of the 95% confidence interval was 1.2%.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXplcmlhbjwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+

PFJlY051bT40MTA1PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+MzA8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA1PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNl

czJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc2MzIiPjQxMDU8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk5hemVyaWFuLCBQLjwvYXV0aG9yPjxh

dXRob3I+TXVlbGxlciwgQy48L2F1dGhvcj48YXV0aG9yPlZhbm5pLCBTLjwvYXV0aG9yPjxhdXRo

b3I+U29laXJvLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+TGVpZGVsLCBCLiBBLjwvYXV0aG9yPjxh

dXRob3I+Q2VyaW5pLCBHLjwvYXV0aG9yPjxhdXRob3I+THVwaWEsIEUuPC9hdXRob3I+PGF1dGhv

cj5QYWxhenpvLCBBLjwvYXV0aG9yPjxhdXRob3I+R3JpZm9uaSwgUy48L2F1dGhvcj48YXV0aG9y

Pk1vcmVsbG8sIEYuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl

c3M+RGVwYXJ0bWVudCBvZiBFbWVyZ2VuY3kgTWVkaWNpbmUsIENhcmVnZ2kgVW5pdmVyc2l0eSBI

b3NwaXRhbCwgTGFyZ28gQnJhbWJpbGxhIDMsIEZpcmVuemUsIEZpcmVuemUsIEl0YWx5LiYjeEQ7

RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5IGFuZCBDYXJkaW92YXNjdWxhciBSZXNlYXJjaCBJbnN0

aXR1dGUgQmFzZWwgKENSSUIpLCBVbml2ZXJzaXR5IEhvc3BpdGFsIG9mIEJhc2VsLCBQZXRlcnNn

cmFiZW4gNCwgQmFzZWwsIFN3aXR6ZXJsYW5kLiYjeEQ7RW1lcmdlbmN5IENhcmUgVW5pdCwgSGVh

cnQgSW5zdGl0dXRlLCBVbml2ZXJzaXR5IG9mIFNhbyBQYXVsbywgQXYuIERyLiBFbmVhcyBDYXJ2

YWxobyBkZSBBZ3VpYXIsIDQ0IC0gQ2VycXVlaXJhIENlc2FyLCBTYW8gUGF1bG8sIEJyYXppbC4m

I3hEO0RlcGFydG1lbnQgb2YgRW1lcmdlbmN5IE1lZGljaW5lLCBDYW1wdXMgQmVuamFtaW4gRnJh

bmtsaW4sIENoYXJpdGUgLSBVbml2ZXJzaXRhdHNtZWRpemluIEJlcmxpbiwgSGluZGVuYnVyZ2Rh

bW0gMzAsIEJlcmxpbiwgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgRW1lcmdlbmN5IE1lZGlj

aW5lLCBTLkMuVS4gTWVkaWNpbmEgZCZhcG9zO1VyZ2VuemEsIE1vbGluZXR0ZSBIb3NwaXRhbCwg

QS5PLlUuIENpdHRhIGRlbGxhIFNhbHV0ZSBlIGRlbGxhIFNjaWVuemEsIENvcnNvIEJyYW1hbnRl

IDg4LCBUb3Jpbm8sIEl0YWx5LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludGVncmF0

aW9uIG9mIHRyYW5zdGhvcmFjaWMgZm9jdXNlZCBjYXJkaWFjIHVsdHJhc291bmQgaW4gdGhlIGRp

YWdub3N0aWMgYWxnb3JpdGhtIGZvciBzdXNwZWN0ZWQgYWN1dGUgYW9ydGljIHN5bmRyb21lczwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0

bGVzPjxwYWdlcz4xOTUyLTE5NjA8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48bnVtYmVyPjI0

PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFvcnRpYyBkaXNzZWN0aW9uPC9rZXl3b3JkPjxr

ZXl3b3JkPkFvcnRpYyBzeW5kcm9tZTwva2V5d29yZD48a2V5d29yZD5EaWFnbm9zaXM8L2tleXdv

cmQ+PGtleXdvcmQ+RWNob2NhcmRpb2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5VbHRyYXNvdW5k

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48

ZGF0ZT5KdW4gMjE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVs

ZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMx

MjI2MjE0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3

dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMTIyNjIxNDwvdXJsPjx1cmw+aHR0cHM6Ly9hY2Fk

ZW1pYy5vdXAuY29tL2V1cmhlYXJ0ai9hcnRpY2xlLWFic3RyYWN0LzQwLzI0LzE5NTIvNTQ3OTg2

OT9yZWRpcmVjdGVkRnJvbT1mdWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh6MjA3PC9lbGVjdHJvbmlj

LXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXplcmlhbjwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+

PFJlY051bT40MTA1PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+MzA8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA1PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNl

czJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc2MzIiPjQxMDU8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk5hemVyaWFuLCBQLjwvYXV0aG9yPjxh

dXRob3I+TXVlbGxlciwgQy48L2F1dGhvcj48YXV0aG9yPlZhbm5pLCBTLjwvYXV0aG9yPjxhdXRo

b3I+U29laXJvLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+TGVpZGVsLCBCLiBBLjwvYXV0aG9yPjxh

dXRob3I+Q2VyaW5pLCBHLjwvYXV0aG9yPjxhdXRob3I+THVwaWEsIEUuPC9hdXRob3I+PGF1dGhv

cj5QYWxhenpvLCBBLjwvYXV0aG9yPjxhdXRob3I+R3JpZm9uaSwgUy48L2F1dGhvcj48YXV0aG9y

Pk1vcmVsbG8sIEYuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl

c3M+RGVwYXJ0bWVudCBvZiBFbWVyZ2VuY3kgTWVkaWNpbmUsIENhcmVnZ2kgVW5pdmVyc2l0eSBI

b3NwaXRhbCwgTGFyZ28gQnJhbWJpbGxhIDMsIEZpcmVuemUsIEZpcmVuemUsIEl0YWx5LiYjeEQ7

RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5IGFuZCBDYXJkaW92YXNjdWxhciBSZXNlYXJjaCBJbnN0

aXR1dGUgQmFzZWwgKENSSUIpLCBVbml2ZXJzaXR5IEhvc3BpdGFsIG9mIEJhc2VsLCBQZXRlcnNn

cmFiZW4gNCwgQmFzZWwsIFN3aXR6ZXJsYW5kLiYjeEQ7RW1lcmdlbmN5IENhcmUgVW5pdCwgSGVh

cnQgSW5zdGl0dXRlLCBVbml2ZXJzaXR5IG9mIFNhbyBQYXVsbywgQXYuIERyLiBFbmVhcyBDYXJ2

YWxobyBkZSBBZ3VpYXIsIDQ0IC0gQ2VycXVlaXJhIENlc2FyLCBTYW8gUGF1bG8sIEJyYXppbC4m

I3hEO0RlcGFydG1lbnQgb2YgRW1lcmdlbmN5IE1lZGljaW5lLCBDYW1wdXMgQmVuamFtaW4gRnJh

bmtsaW4sIENoYXJpdGUgLSBVbml2ZXJzaXRhdHNtZWRpemluIEJlcmxpbiwgSGluZGVuYnVyZ2Rh

bW0gMzAsIEJlcmxpbiwgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgRW1lcmdlbmN5IE1lZGlj

aW5lLCBTLkMuVS4gTWVkaWNpbmEgZCZhcG9zO1VyZ2VuemEsIE1vbGluZXR0ZSBIb3NwaXRhbCwg

QS5PLlUuIENpdHRhIGRlbGxhIFNhbHV0ZSBlIGRlbGxhIFNjaWVuemEsIENvcnNvIEJyYW1hbnRl

IDg4LCBUb3Jpbm8sIEl0YWx5LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludGVncmF0

aW9uIG9mIHRyYW5zdGhvcmFjaWMgZm9jdXNlZCBjYXJkaWFjIHVsdHJhc291bmQgaW4gdGhlIGRp

YWdub3N0aWMgYWxnb3JpdGhtIGZvciBzdXNwZWN0ZWQgYWN1dGUgYW9ydGljIHN5bmRyb21lczwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0

bGVzPjxwYWdlcz4xOTUyLTE5NjA8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48bnVtYmVyPjI0

PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFvcnRpYyBkaXNzZWN0aW9uPC9rZXl3b3JkPjxr

ZXl3b3JkPkFvcnRpYyBzeW5kcm9tZTwva2V5d29yZD48a2V5d29yZD5EaWFnbm9zaXM8L2tleXdv

cmQ+PGtleXdvcmQ+RWNob2NhcmRpb2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5VbHRyYXNvdW5k

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48

ZGF0ZT5KdW4gMjE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVs

ZWN0cm9uaWMpJiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMx

MjI2MjE0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3

dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMTIyNjIxNDwvdXJsPjx1cmw+aHR0cHM6Ly9hY2Fk

ZW1pYy5vdXAuY29tL2V1cmhlYXJ0ai9hcnRpY2xlLWFic3RyYWN0LzQwLzI0LzE5NTIvNTQ3OTg2

OT9yZWRpcmVjdGVkRnJvbT1mdWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh6MjA3PC9lbGVjdHJvbmlj

LXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA 30 These findings confirm the important role of TTE in the diagnostic strategy of AAS as suggested in the last ESC guidelines on the management of aortic diseases.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FcmJlbDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

Y051bT40MTA2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

MzE8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA2PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc2NzIiPjQxMDY8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkVyYmVsLCBSLjwvYXV0aG9yPjxhdXRob3I+

QWJveWFucywgVi48L2F1dGhvcj48YXV0aG9yPkJvaWxlYXUsIEMuPC9hdXRob3I+PGF1dGhvcj5C

b3Nzb25lLCBFLjwvYXV0aG9yPjxhdXRob3I+QmFydG9sb21lbywgUi4gRC48L2F1dGhvcj48YXV0

aG9yPkVnZ2VicmVjaHQsIEguPC9hdXRob3I+PGF1dGhvcj5FdmFuZ2VsaXN0YSwgQS48L2F1dGhv

cj48YXV0aG9yPkZhbGssIFYuPC9hdXRob3I+PGF1dGhvcj5GcmFuaywgSC48L2F1dGhvcj48YXV0

aG9yPkdhZW1wZXJsaSwgTy48L2F1dGhvcj48YXV0aG9yPkdyYWJlbndvZ2VyLCBNLjwvYXV0aG9y

PjxhdXRob3I+SGF2ZXJpY2gsIEEuPC9hdXRob3I+PGF1dGhvcj5JdW5nLCBCLjwvYXV0aG9yPjxh

dXRob3I+TWFub2xpcywgQS4gSi48L2F1dGhvcj48YXV0aG9yPk1laWpib29tLCBGLjwvYXV0aG9y

PjxhdXRob3I+TmllbmFiZXIsIEMuIEEuPC9hdXRob3I+PGF1dGhvcj5Sb2ZmaSwgTS48L2F1dGhv

cj48YXV0aG9yPlJvdXNzZWF1LCBILjwvYXV0aG9yPjxhdXRob3I+U2VjaHRlbSwgVS48L2F1dGhv

cj48YXV0aG9yPlNpcm5lcywgUC4gQS48L2F1dGhvcj48YXV0aG9yPkFsbG1lbiwgUi4gUy48L2F1

dGhvcj48YXV0aG9yPlZyaW50cywgQy4gSi48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIENvbW1p

dHRlZSBmb3IgUHJhY3RpY2UgR3VpZGVsaW5lczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE0IEVTQyBHdWlkZWxpbmVzIG9uIHRoZSBkaWFnbm9zaXMg

YW5kIHRyZWF0bWVudCBvZiBhb3J0aWMgZGlzZWFzZXM6IERvY3VtZW50IGNvdmVyaW5nIGFjdXRl

IGFuZCBjaHJvbmljIGFvcnRpYyBkaXNlYXNlcyBvZiB0aGUgdGhvcmFjaWMgYW5kIGFiZG9taW5h

bCBhb3J0YSBvZiB0aGUgYWR1bHQuIFRoZSBUYXNrIEZvcmNlIGZvciB0aGUgRGlhZ25vc2lzIGFu

ZCBUcmVhdG1lbnQgb2YgQW9ydGljIERpc2Vhc2VzIG9mIHRoZSBFdXJvcGVhbiBTb2NpZXR5IG9m

IENhcmRpb2xvZ3kgKEVTQyk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3Nl

Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+Mjg3My05MjY8L3BhZ2VzPjx2b2x1bWU+MzU8

L3ZvbHVtZT48bnVtYmVyPjQxPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIERpc2Vh

c2U8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+QW5ldXJ5

c20sIERpc3NlY3RpbmcvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+QW5ldXJ5

c20sIEZhbHNlL2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPipBb3J0YSwgQWJk

b21pbmFsL2luanVyaWVzPC9rZXl3b3JkPjxrZXl3b3JkPipBb3J0YSwgVGhvcmFjaWMvaW5qdXJp

ZXM8L2tleXdvcmQ+PGtleXdvcmQ+QW9ydGljIERpc2Vhc2VzL2NvbXBsaWNhdGlvbnMvKmRpYWdu

b3Npcy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5Bb3J0aWMgVmFsdmU8L2tleXdvcmQ+PGtl

eXdvcmQ+QXRoZXJvc2NsZXJvc2lzL2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3Jk

PkNhcmRpb3Zhc2N1bGFyIEFnZW50cy90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+

Q2xpbmljYWwgTGFib3JhdG9yeSBUZWNobmlxdWVzL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+

RGlhZ25vc3RpYyBJbWFnaW5nL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RWFybHkgRGlhZ25v

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkVuZG92YXNjdWxhciBQcm9jZWR1cmVzL21ldGhvZHM8L2tl

eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgRGlzZWFzZXMs

IEluYm9ybi9jb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPkhlYXJ0IERlZmVjdHMsIENv

bmdlbml0YWwvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcnQgVmFsdmUg

RGlzZWFzZXMvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvbWEvZGlh

Z25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3Jk

PkxvbmctVGVybSBDYXJlL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48

a2V5d29yZD5OZW9wbGFzbXMsIFZhc2N1bGFyIFRpc3N1ZS9kaWFnbm9zaXMvdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5QaHlzaWNhbCBFeGFtaW5hdGlvbi9tZXRob2RzPC9rZXl3b3JkPjxrZXl3

b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5WYXNjdWxhciBDYWxjaWZpY2F0aW9u

L2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlZhc2N1bGFyIFN0aWZmbmVzcy9w

aHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlZhc2N1bGFyIFN1cmdpY2FsIFByb2NlZHVyZXMv

bWV0aG9kczwva2V5d29yZD48a2V5d29yZD5BYmRvbWluYWwgYW9ydGljIGFuZXVyeXNtPC9rZXl3

b3JkPjxrZXl3b3JkPkFjdXRlIGFvcnRpYyBzeW5kcm9tZTwva2V5d29yZD48a2V5d29yZD5Bb3J0

aWMgYW5ldXJ5c208L2tleXdvcmQ+PGtleXdvcmQ+QW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxr

ZXl3b3JkPkFvcnRpYyBkaXNzZWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkFvcnRpYyB0dW1vdXJz

PC9rZXl3b3JkPjxrZXl3b3JkPkFvcnRpdGlzPC9rZXl3b3JkPjxrZXl3b3JkPkNvbmdlbml0YWwg

YW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxrZXl3b3JkPkVuZG92YXNjdWxhciB0aGVyYXB5PC9r

ZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgYW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxrZXl3b3Jk

Pkd1aWRlbGluZXM8L2tleXdvcmQ+PGtleXdvcmQ+SW50cmFtdXJhbCBoYWVtYXRvbWE8L2tleXdv

cmQ+PGtleXdvcmQ+UGVuZXRyYXRpbmcgYW9ydGljIHVsY2VyPC9rZXl3b3JkPjxrZXl3b3JkPlRo

cm9tYm9lbWJvbGljIGFvcnRpYyBkaXNlYXNlczwva2V5d29yZD48a2V5d29yZD5UcmF1bWF0aWMg

YW9ydGljIGluanVyeTwva2V5d29yZD48a2V5d29yZD5WYXNjdWxhciBzdXJnZXJ5PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3Yg

MTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjItOTY0NSAoRWxlY3Ryb25pYykm

I3hEOzAxOTUtNjY4WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjUxNzMzNDA8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzI1MTczMzQwPC91cmw+PHVybD5odHRwczovL3dhdGVybWFyay5zaWx2

ZXJjaGFpci5jb20vZWh1MjgxLnBkZj90b2tlbj1BUUVDQUhpMjA4QkU0OU9vYW45a2toV19FcmN5

N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQW4wd2dnSjVCZ2txaGtpRzl3MEJCd2FnZ2dKcU1JSUNa

Z0lCQURDQ0FsOEdDU3FHU0liM0RRRUhBVEFlQmdsZ2hrZ0JaUU1FQVM0d0VRUU1Cd2c1LVE5YW5V

QThJQkdIQWdFUWdJSUNNQmFVTUd4WjlJOFdNd0lOQ3llNmliTEVhTlh4NFp5YXRrZzdaTDdCUVpQ

MUtyR083MmVoM1ZZZnJhQWNBR2xiUFNoS3phdWNFYk9Gb3pQV08tazVYVzZFRE9oWF9lSWoxNUZJ

bFFOQzBOV3ZzRWFDWnNVc2o5aWJqbmN2dkViY09KVXBVYWQxQnJnT1lncmpXREhxNEU1VjdRdGlj

TnJ4QkRoMkw1cV9sWnZTa2hrN0V2UU5hc3NMb0VwbjNYbERhbHpJWHlIS2Z6OFlHNUFjTWxtcGxm

dVBIeUtSN2ZFR0pRc2xVbE1rUXVjb3ppeHB1Q1FhTEIxenFJTjB5MENVUWRZeWlabVhfaHI5bmJL

cWh3ZjRXNldCT19FU3BrS2RzWDgtVVZPbVA1M2w2UnllbWNLblU1STJJZWJUUnh0Yk9DamJxa0g3

VUNUWXR2VDVQQzlZR1I2cGpfNEJseU1ZcEotTlZVMmNXTU1FZHlteDYzRHFYSVZWXzMySU1UWVJj

OC1WVW84aG1VWU9UWVJFWlV6MmIzVmdoa21BcFlPdEI1M1ozMWJ2R0xSc29VMXFQS2pITXlMQlh2

elpJc3Q3Y2Q5cWtFZ3drVG1PN1cwSjJWT25XU1JlTERwR3U2dnlfNlVtMFEzQzlwZ3hKR0wyMUxC

Y0RabW41VWkybWdJd2xBb3pmZGpIRUdwbFVoZ1prVEk0UVktM3ZfSjFtOEo5SGkwV1N1dmFEeFVB

WlJpMktfQXlRbWxJZ1BRTWZ2X28tQk9wSVZIY1h3ME9VaF91bEdUVTZ0ZHdxNXQ4STAzenNxU2M5

TEdsQV9wUk5naWJ4Q0hmNW9HSjZXVVAzVEozV0daM1NYMkZncVBidEtob2lBLWN2VGJRNlFSR2dX

TmhnZ05jRkotTzlROE5WMG9ES3I4aUpnSFlxTXNpV3lGVnZfQ0ZEUk9YMEdLOWtvOTduRENlUVZB

a2Q0OUh2cHBLNlR2c0U3d0ZUcWFlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHUyODE8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FcmJlbDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

Y051bT40MTA2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

MzE8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA2PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc2NzIiPjQxMDY8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkVyYmVsLCBSLjwvYXV0aG9yPjxhdXRob3I+

QWJveWFucywgVi48L2F1dGhvcj48YXV0aG9yPkJvaWxlYXUsIEMuPC9hdXRob3I+PGF1dGhvcj5C

b3Nzb25lLCBFLjwvYXV0aG9yPjxhdXRob3I+QmFydG9sb21lbywgUi4gRC48L2F1dGhvcj48YXV0

aG9yPkVnZ2VicmVjaHQsIEguPC9hdXRob3I+PGF1dGhvcj5FdmFuZ2VsaXN0YSwgQS48L2F1dGhv

cj48YXV0aG9yPkZhbGssIFYuPC9hdXRob3I+PGF1dGhvcj5GcmFuaywgSC48L2F1dGhvcj48YXV0

aG9yPkdhZW1wZXJsaSwgTy48L2F1dGhvcj48YXV0aG9yPkdyYWJlbndvZ2VyLCBNLjwvYXV0aG9y

PjxhdXRob3I+SGF2ZXJpY2gsIEEuPC9hdXRob3I+PGF1dGhvcj5JdW5nLCBCLjwvYXV0aG9yPjxh

dXRob3I+TWFub2xpcywgQS4gSi48L2F1dGhvcj48YXV0aG9yPk1laWpib29tLCBGLjwvYXV0aG9y

PjxhdXRob3I+TmllbmFiZXIsIEMuIEEuPC9hdXRob3I+PGF1dGhvcj5Sb2ZmaSwgTS48L2F1dGhv

cj48YXV0aG9yPlJvdXNzZWF1LCBILjwvYXV0aG9yPjxhdXRob3I+U2VjaHRlbSwgVS48L2F1dGhv

cj48YXV0aG9yPlNpcm5lcywgUC4gQS48L2F1dGhvcj48YXV0aG9yPkFsbG1lbiwgUi4gUy48L2F1

dGhvcj48YXV0aG9yPlZyaW50cywgQy4gSi48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIENvbW1p

dHRlZSBmb3IgUHJhY3RpY2UgR3VpZGVsaW5lczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE0IEVTQyBHdWlkZWxpbmVzIG9uIHRoZSBkaWFnbm9zaXMg

YW5kIHRyZWF0bWVudCBvZiBhb3J0aWMgZGlzZWFzZXM6IERvY3VtZW50IGNvdmVyaW5nIGFjdXRl

IGFuZCBjaHJvbmljIGFvcnRpYyBkaXNlYXNlcyBvZiB0aGUgdGhvcmFjaWMgYW5kIGFiZG9taW5h

bCBhb3J0YSBvZiB0aGUgYWR1bHQuIFRoZSBUYXNrIEZvcmNlIGZvciB0aGUgRGlhZ25vc2lzIGFu

ZCBUcmVhdG1lbnQgb2YgQW9ydGljIERpc2Vhc2VzIG9mIHRoZSBFdXJvcGVhbiBTb2NpZXR5IG9m

IENhcmRpb2xvZ3kgKEVTQyk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3Nl

Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+Mjg3My05MjY8L3BhZ2VzPjx2b2x1bWU+MzU8

L3ZvbHVtZT48bnVtYmVyPjQxPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIERpc2Vh

c2U8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+QW5ldXJ5

c20sIERpc3NlY3RpbmcvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+QW5ldXJ5

c20sIEZhbHNlL2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPipBb3J0YSwgQWJk

b21pbmFsL2luanVyaWVzPC9rZXl3b3JkPjxrZXl3b3JkPipBb3J0YSwgVGhvcmFjaWMvaW5qdXJp

ZXM8L2tleXdvcmQ+PGtleXdvcmQ+QW9ydGljIERpc2Vhc2VzL2NvbXBsaWNhdGlvbnMvKmRpYWdu

b3Npcy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5Bb3J0aWMgVmFsdmU8L2tleXdvcmQ+PGtl

eXdvcmQ+QXRoZXJvc2NsZXJvc2lzL2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3Jk

PkNhcmRpb3Zhc2N1bGFyIEFnZW50cy90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+

Q2xpbmljYWwgTGFib3JhdG9yeSBUZWNobmlxdWVzL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+

RGlhZ25vc3RpYyBJbWFnaW5nL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RWFybHkgRGlhZ25v

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkVuZG92YXNjdWxhciBQcm9jZWR1cmVzL21ldGhvZHM8L2tl

eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgRGlzZWFzZXMs

IEluYm9ybi9jb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPkhlYXJ0IERlZmVjdHMsIENv

bmdlbml0YWwvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcnQgVmFsdmUg

RGlzZWFzZXMvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvbWEvZGlh

Z25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3Jk

PkxvbmctVGVybSBDYXJlL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48

a2V5d29yZD5OZW9wbGFzbXMsIFZhc2N1bGFyIFRpc3N1ZS9kaWFnbm9zaXMvdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5QaHlzaWNhbCBFeGFtaW5hdGlvbi9tZXRob2RzPC9rZXl3b3JkPjxrZXl3

b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5WYXNjdWxhciBDYWxjaWZpY2F0aW9u

L2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlZhc2N1bGFyIFN0aWZmbmVzcy9w

aHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlZhc2N1bGFyIFN1cmdpY2FsIFByb2NlZHVyZXMv

bWV0aG9kczwva2V5d29yZD48a2V5d29yZD5BYmRvbWluYWwgYW9ydGljIGFuZXVyeXNtPC9rZXl3

b3JkPjxrZXl3b3JkPkFjdXRlIGFvcnRpYyBzeW5kcm9tZTwva2V5d29yZD48a2V5d29yZD5Bb3J0

aWMgYW5ldXJ5c208L2tleXdvcmQ+PGtleXdvcmQ+QW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxr

ZXl3b3JkPkFvcnRpYyBkaXNzZWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkFvcnRpYyB0dW1vdXJz

PC9rZXl3b3JkPjxrZXl3b3JkPkFvcnRpdGlzPC9rZXl3b3JkPjxrZXl3b3JkPkNvbmdlbml0YWwg

YW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxrZXl3b3JkPkVuZG92YXNjdWxhciB0aGVyYXB5PC9r

ZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgYW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxrZXl3b3Jk

Pkd1aWRlbGluZXM8L2tleXdvcmQ+PGtleXdvcmQ+SW50cmFtdXJhbCBoYWVtYXRvbWE8L2tleXdv

cmQ+PGtleXdvcmQ+UGVuZXRyYXRpbmcgYW9ydGljIHVsY2VyPC9rZXl3b3JkPjxrZXl3b3JkPlRo

cm9tYm9lbWJvbGljIGFvcnRpYyBkaXNlYXNlczwva2V5d29yZD48a2V5d29yZD5UcmF1bWF0aWMg

YW9ydGljIGluanVyeTwva2V5d29yZD48a2V5d29yZD5WYXNjdWxhciBzdXJnZXJ5PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3Yg

MTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjItOTY0NSAoRWxlY3Ryb25pYykm

I3hEOzAxOTUtNjY4WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjUxNzMzNDA8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzI1MTczMzQwPC91cmw+PHVybD5odHRwczovL3dhdGVybWFyay5zaWx2

ZXJjaGFpci5jb20vZWh1MjgxLnBkZj90b2tlbj1BUUVDQUhpMjA4QkU0OU9vYW45a2toV19FcmN5

N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQW4wd2dnSjVCZ2txaGtpRzl3MEJCd2FnZ2dKcU1JSUNa

Z0lCQURDQ0FsOEdDU3FHU0liM0RRRUhBVEFlQmdsZ2hrZ0JaUU1FQVM0d0VRUU1Cd2c1LVE5YW5V

QThJQkdIQWdFUWdJSUNNQmFVTUd4WjlJOFdNd0lOQ3llNmliTEVhTlh4NFp5YXRrZzdaTDdCUVpQ

MUtyR083MmVoM1ZZZnJhQWNBR2xiUFNoS3phdWNFYk9Gb3pQV08tazVYVzZFRE9oWF9lSWoxNUZJ

bFFOQzBOV3ZzRWFDWnNVc2o5aWJqbmN2dkViY09KVXBVYWQxQnJnT1lncmpXREhxNEU1VjdRdGlj

TnJ4QkRoMkw1cV9sWnZTa2hrN0V2UU5hc3NMb0VwbjNYbERhbHpJWHlIS2Z6OFlHNUFjTWxtcGxm

dVBIeUtSN2ZFR0pRc2xVbE1rUXVjb3ppeHB1Q1FhTEIxenFJTjB5MENVUWRZeWlabVhfaHI5bmJL

cWh3ZjRXNldCT19FU3BrS2RzWDgtVVZPbVA1M2w2UnllbWNLblU1STJJZWJUUnh0Yk9DamJxa0g3

VUNUWXR2VDVQQzlZR1I2cGpfNEJseU1ZcEotTlZVMmNXTU1FZHlteDYzRHFYSVZWXzMySU1UWVJj

OC1WVW84aG1VWU9UWVJFWlV6MmIzVmdoa21BcFlPdEI1M1ozMWJ2R0xSc29VMXFQS2pITXlMQlh2

elpJc3Q3Y2Q5cWtFZ3drVG1PN1cwSjJWT25XU1JlTERwR3U2dnlfNlVtMFEzQzlwZ3hKR0wyMUxC

Y0RabW41VWkybWdJd2xBb3pmZGpIRUdwbFVoZ1prVEk0UVktM3ZfSjFtOEo5SGkwV1N1dmFEeFVB

WlJpMktfQXlRbWxJZ1BRTWZ2X28tQk9wSVZIY1h3ME9VaF91bEdUVTZ0ZHdxNXQ4STAzenNxU2M5

TEdsQV9wUk5naWJ4Q0hmNW9HSjZXVVAzVEozV0daM1NYMkZncVBidEtob2lBLWN2VGJRNlFSR2dX

TmhnZ05jRkotTzlROE5WMG9ES3I4aUpnSFlxTXNpV3lGVnZfQ0ZEUk9YMEdLOWtvOTduRENlUVZB

a2Q0OUh2cHBLNlR2c0U3d0ZUcWFlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHUyODE8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA 31The term AAS has become commonplace, but constitutes a range of disease entities, which may not have the same pathophysiological mechanisms, responses to treatment or outlook. Among 1,012 patients, those with intra-mural haematoma (IMH) (n=340) had a much better short- and long-term mortality than those patients with AD (n=672).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BaG48L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNO

dW0+NDEwNzwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQiPjMy

PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDEwNzwvcmVjLW51bWJl

cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMycjc1

MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5OTM3NzI0Ij40MTA3PC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BaG4sIEouIE0uPC9hdXRob3I+PGF1dGhvcj5L

aW0sIEguPC9hdXRob3I+PGF1dGhvcj5Ld29uLCBPLjwvYXV0aG9yPjxhdXRob3I+T20sIFMuIFku

PC9hdXRob3I+PGF1dGhvcj5IZW8sIFIuPC9hdXRob3I+PGF1dGhvcj5MZWUsIFMuPC9hdXRob3I+

PGF1dGhvcj5LaW0sIEQuIEguPC9hdXRob3I+PGF1dGhvcj5LaW0sIEguIEouPC9hdXRob3I+PGF1

dGhvcj5LaW0sIEouIEIuPC9hdXRob3I+PGF1dGhvcj5KdW5nLCBTLiBILjwvYXV0aG9yPjxhdXRo

b3I+Q2hvbywgUy4gSi48L2F1dGhvcj48YXV0aG9yPlNvbmcsIEouIE0uPC9hdXRob3I+PGF1dGhv

cj5LYW5nLCBELiBILjwvYXV0aG9yPjxhdXRob3I+Q2h1bmcsIEMuIEguPC9hdXRob3I+PGF1dGhv

cj5MZWUsIEouIFcuPC9hdXRob3I+PGF1dGhvcj5Tb25nLCBKLiBLLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIEhl

YXJ0IEluc3RpdHV0ZSwgQXNhbiBNZWRpY2FsIENlbnRlciwgVW5pdmVyc2l0eSBvZiBVbHNhbiBD

b2xsZWdlIG9mIE1lZGljaW5lLCA4OCwgT2x5bXBpYy1ybyA0My1naWwsIFNvbmdwYS1ndSwgU2Vv

dWwgMDU1MDUsIFJlcHVibGljIG9mIEtvcmVhLiYjeEQ7RGl2aXNpb24gb2YgQ2FyZGlhYyBTdXJn

ZXJ5LCBIZWFydCBJbnN0aXR1dGUsIEFzYW4gTWVkaWNhbCBDZW50ZXIsIFVuaXZlcnNpdHkgb2Yg

VWxzYW4gQ29sbGVnZSBvZiBNZWRpY2luZSwgODgsIE9seW1waWMtcm8gNDMtZ2lsLCBTb25ncGEt

Z3UsIFNlb3VsIDA1NTA1LCBSZXB1YmxpYyBvZiBLb3JlYS48L2F1dGgtYWRkcmVzcz48dGl0bGVz

Pjx0aXRsZT5EaWZmZXJlbnRpYWwgY2xpbmljYWwgZmVhdHVyZXMgYW5kIGxvbmctdGVybSBwcm9n

bm9zaXMgb2YgYWN1dGUgYW9ydGljIHN5bmRyb21lIGFjY29yZGluZyB0byBkaXNlYXNlIGVudGl0

eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwYWdlcz4yNzI3LTI3MzY8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48bnVtYmVy

PjMyPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIGFvcnRpYyBzeW5kcm9tZTwva2V5

d29yZD48a2V5d29yZD5Bb3J0aWMgZGlzc2VjdGlvbjwva2V5d29yZD48a2V5d29yZD5Bb3J0aWMg

aW50cmFtdXJhbCBoYWVtYXRvbWE8L2tleXdvcmQ+PGtleXdvcmQ+T3V0Y29tZTwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDIx

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYj

eEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMTIyMDIzMjwvYWNj

ZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0u

bmloLmdvdi9wdWJtZWQvMzEyMjAyMzI8L3VybD48dXJsPmh0dHBzOi8vYWNhZGVtaWMub3VwLmNv

bS9ldXJoZWFydGovYXJ0aWNsZS1hYnN0cmFjdC80MC8zMi8yNzI3LzU0MzI3MTk/cmVkaXJlY3Rl

ZEZyb209ZnVsbHRleHQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVhcnRqL2VoejE1MzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BaG48L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNO

dW0+NDEwNzwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQiPjMy

PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDEwNzwvcmVjLW51bWJl

cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMycjc1

MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5OTM3NzI0Ij40MTA3PC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BaG4sIEouIE0uPC9hdXRob3I+PGF1dGhvcj5L

aW0sIEguPC9hdXRob3I+PGF1dGhvcj5Ld29uLCBPLjwvYXV0aG9yPjxhdXRob3I+T20sIFMuIFku

PC9hdXRob3I+PGF1dGhvcj5IZW8sIFIuPC9hdXRob3I+PGF1dGhvcj5MZWUsIFMuPC9hdXRob3I+

PGF1dGhvcj5LaW0sIEQuIEguPC9hdXRob3I+PGF1dGhvcj5LaW0sIEguIEouPC9hdXRob3I+PGF1

dGhvcj5LaW0sIEouIEIuPC9hdXRob3I+PGF1dGhvcj5KdW5nLCBTLiBILjwvYXV0aG9yPjxhdXRo

b3I+Q2hvbywgUy4gSi48L2F1dGhvcj48YXV0aG9yPlNvbmcsIEouIE0uPC9hdXRob3I+PGF1dGhv

cj5LYW5nLCBELiBILjwvYXV0aG9yPjxhdXRob3I+Q2h1bmcsIEMuIEguPC9hdXRob3I+PGF1dGhv

cj5MZWUsIEouIFcuPC9hdXRob3I+PGF1dGhvcj5Tb25nLCBKLiBLLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIEhl

YXJ0IEluc3RpdHV0ZSwgQXNhbiBNZWRpY2FsIENlbnRlciwgVW5pdmVyc2l0eSBvZiBVbHNhbiBD

b2xsZWdlIG9mIE1lZGljaW5lLCA4OCwgT2x5bXBpYy1ybyA0My1naWwsIFNvbmdwYS1ndSwgU2Vv

dWwgMDU1MDUsIFJlcHVibGljIG9mIEtvcmVhLiYjeEQ7RGl2aXNpb24gb2YgQ2FyZGlhYyBTdXJn

ZXJ5LCBIZWFydCBJbnN0aXR1dGUsIEFzYW4gTWVkaWNhbCBDZW50ZXIsIFVuaXZlcnNpdHkgb2Yg

VWxzYW4gQ29sbGVnZSBvZiBNZWRpY2luZSwgODgsIE9seW1waWMtcm8gNDMtZ2lsLCBTb25ncGEt

Z3UsIFNlb3VsIDA1NTA1LCBSZXB1YmxpYyBvZiBLb3JlYS48L2F1dGgtYWRkcmVzcz48dGl0bGVz

Pjx0aXRsZT5EaWZmZXJlbnRpYWwgY2xpbmljYWwgZmVhdHVyZXMgYW5kIGxvbmctdGVybSBwcm9n

bm9zaXMgb2YgYWN1dGUgYW9ydGljIHN5bmRyb21lIGFjY29yZGluZyB0byBkaXNlYXNlIGVudGl0

eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwYWdlcz4yNzI3LTI3MzY8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48bnVtYmVy

PjMyPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIGFvcnRpYyBzeW5kcm9tZTwva2V5

d29yZD48a2V5d29yZD5Bb3J0aWMgZGlzc2VjdGlvbjwva2V5d29yZD48a2V5d29yZD5Bb3J0aWMg

aW50cmFtdXJhbCBoYWVtYXRvbWE8L2tleXdvcmQ+PGtleXdvcmQ+T3V0Y29tZTwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDIx

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYj

eEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMTIyMDIzMjwvYWNj

ZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0u

bmloLmdvdi9wdWJtZWQvMzEyMjAyMzI8L3VybD48dXJsPmh0dHBzOi8vYWNhZGVtaWMub3VwLmNv

bS9ldXJoZWFydGovYXJ0aWNsZS1hYnN0cmFjdC80MC8zMi8yNzI3LzU0MzI3MTk/cmVkaXJlY3Rl

ZEZyb209ZnVsbHRleHQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVhcnRqL2VoejE1MzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA 32 The overall crude in-hospital mortality of type A AD was 15.0% with an adjusted hazard ratio (aHR) of 30.4; compared to type A IMH mortality of 8.0% with aHR of 4.85. Mortality of type B AD was 5.0%, with aHR?of 3.51, compared to type B IMH 1.5% with aHR of 1.00 (the reference group).Identifying patients with Marfan syndrome who are at particular risk of AD is currently based on the absolute diameter of the aorta, the growth rate, and the presence/absence of a family history of AD. A novel additional approach may be evaluation of the longitudinal strain of the proximal aorta by magnetic resonance imaging (MRI, Figure 4A).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdWFsYTwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MTA4PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

MzM8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA4PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc3NTQiPjQxMDg8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkd1YWxhLCBBLjwvYXV0aG9yPjxhdXRob3I+

VGVpeGlkby1UdXJhLCBHLjwvYXV0aG9yPjxhdXRob3I+Um9kcmlndWV6LVBhbG9tYXJlcywgSi48

L2F1dGhvcj48YXV0aG9yPlJ1aXotTXVub3osIEEuPC9hdXRob3I+PGF1dGhvcj5EdXgtU2FudG95

LCBMLjwvYXV0aG9yPjxhdXRob3I+VmlsbGFsdmEsIE4uPC9hdXRob3I+PGF1dGhvcj5HcmFuYXRv

LCBDLjwvYXV0aG9yPjxhdXRob3I+R2FsaWFuLCBMLjwvYXV0aG9yPjxhdXRob3I+R3V0aWVycmV6

LCBMLjwvYXV0aG9yPjxhdXRob3I+R29uemFsZXotQWx1amFzLCBULjwvYXV0aG9yPjxhdXRob3I+

U2FuY2hleiwgVi48L2F1dGhvcj48YXV0aG9yPkZvcnRlemEsIEEuPC9hdXRob3I+PGF1dGhvcj5H

YXJjaWEtRG9yYWRvLCBELjwvYXV0aG9yPjxhdXRob3I+RXZhbmdlbGlzdGEsIEEuPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJk

aW9sb2d5LCBIb3NwaXRhbCBVbml2ZXJzaXRhcmkgVmFsbCBkJmFwb3M7SGVicm9uLCBDSUJFUi1D

ViwgVmFsbCBkJmFwb3M7SGVicm9uIGluc3RpdHV0IGRlIFJlY2VyY2EsIFVuaXZlcnNpdGF0IEF1

dG9ub21hIGRlIEJhcmNlbG9uYSwgUGFzZW8gVmFsbCBkJmFwb3M7SGVicm9uIDExOS0xMjksIEJh

cmNlbG9uYSwgU3BhaW4uJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIEhvc3BpdGFsIGRv

Y2UgZGUgT2N0dWJyZSwgQXZlbmlkYSBDb3Jkb2JhLCBNYWRyaWQsIFNwYWluLiYjeEQ7RGVwYXJ0

bWVudCBvZiBDYXJkaWFjIFN1cmdlcnksIEhvc3BpdGFsIFB1ZXJ0YSBkZSBIaWVycm8uIENhbGxl

IE1hbnVlbCBkZSBGYWxsYSwgMSwgTWFqYWRhaG9uZGEsIFNwYWluLjwvYXV0aC1hZGRyZXNzPjx0

aXRsZXM+PHRpdGxlPlByb3hpbWFsIGFvcnRhIGxvbmdpdHVkaW5hbCBzdHJhaW4gcHJlZGljdHMg

YW9ydGljIHJvb3QgZGlsYXRpb24gcmF0ZSBhbmQgYW9ydGljIGV2ZW50cyBpbiBNYXJmYW4gc3lu

ZHJvbWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+MjA0Ny0yMDU1PC9wYWdlcz48dm9sdW1lPjQwPC92b2x1bWU+PG51

bWJlcj4yNTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Bb3J0aWMgZGlsYXRpb248L2tleXdv

cmQ+PGtleXdvcmQ+QW9ydGljIHN0cmFpbjwva2V5d29yZD48a2V5d29yZD5Mb25naXR1ZGluYWwg

c3RyYWluPC9rZXl3b3JkPjxrZXl3b3JkPk1hcmZhbiBzeW5kcm9tZTwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsIDE8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1

LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMwOTc3NzgzPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8zMDk3Nzc4MzwvdXJsPjx1cmw+aHR0cHM6Ly9hY2FkZW1pYy5vdXAuY29tL2V1cmhl

YXJ0ai9hcnRpY2xlLWFic3RyYWN0LzQwLzI1LzIwNDcvNTQ0ODg4MT9yZWRpcmVjdGVkRnJvbT1m

dWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTA5My9ldXJoZWFydGovZWh6MTkxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3Jl

Y29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdWFsYTwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MTA4PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

MzM8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA4PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc3NTQiPjQxMDg8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkd1YWxhLCBBLjwvYXV0aG9yPjxhdXRob3I+

VGVpeGlkby1UdXJhLCBHLjwvYXV0aG9yPjxhdXRob3I+Um9kcmlndWV6LVBhbG9tYXJlcywgSi48

L2F1dGhvcj48YXV0aG9yPlJ1aXotTXVub3osIEEuPC9hdXRob3I+PGF1dGhvcj5EdXgtU2FudG95

LCBMLjwvYXV0aG9yPjxhdXRob3I+VmlsbGFsdmEsIE4uPC9hdXRob3I+PGF1dGhvcj5HcmFuYXRv

LCBDLjwvYXV0aG9yPjxhdXRob3I+R2FsaWFuLCBMLjwvYXV0aG9yPjxhdXRob3I+R3V0aWVycmV6

LCBMLjwvYXV0aG9yPjxhdXRob3I+R29uemFsZXotQWx1amFzLCBULjwvYXV0aG9yPjxhdXRob3I+

U2FuY2hleiwgVi48L2F1dGhvcj48YXV0aG9yPkZvcnRlemEsIEEuPC9hdXRob3I+PGF1dGhvcj5H

YXJjaWEtRG9yYWRvLCBELjwvYXV0aG9yPjxhdXRob3I+RXZhbmdlbGlzdGEsIEEuPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJk

aW9sb2d5LCBIb3NwaXRhbCBVbml2ZXJzaXRhcmkgVmFsbCBkJmFwb3M7SGVicm9uLCBDSUJFUi1D

ViwgVmFsbCBkJmFwb3M7SGVicm9uIGluc3RpdHV0IGRlIFJlY2VyY2EsIFVuaXZlcnNpdGF0IEF1

dG9ub21hIGRlIEJhcmNlbG9uYSwgUGFzZW8gVmFsbCBkJmFwb3M7SGVicm9uIDExOS0xMjksIEJh

cmNlbG9uYSwgU3BhaW4uJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIEhvc3BpdGFsIGRv

Y2UgZGUgT2N0dWJyZSwgQXZlbmlkYSBDb3Jkb2JhLCBNYWRyaWQsIFNwYWluLiYjeEQ7RGVwYXJ0

bWVudCBvZiBDYXJkaWFjIFN1cmdlcnksIEhvc3BpdGFsIFB1ZXJ0YSBkZSBIaWVycm8uIENhbGxl

IE1hbnVlbCBkZSBGYWxsYSwgMSwgTWFqYWRhaG9uZGEsIFNwYWluLjwvYXV0aC1hZGRyZXNzPjx0

aXRsZXM+PHRpdGxlPlByb3hpbWFsIGFvcnRhIGxvbmdpdHVkaW5hbCBzdHJhaW4gcHJlZGljdHMg

YW9ydGljIHJvb3QgZGlsYXRpb24gcmF0ZSBhbmQgYW9ydGljIGV2ZW50cyBpbiBNYXJmYW4gc3lu

ZHJvbWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+MjA0Ny0yMDU1PC9wYWdlcz48dm9sdW1lPjQwPC92b2x1bWU+PG51

bWJlcj4yNTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Bb3J0aWMgZGlsYXRpb248L2tleXdv

cmQ+PGtleXdvcmQ+QW9ydGljIHN0cmFpbjwva2V5d29yZD48a2V5d29yZD5Mb25naXR1ZGluYWwg

c3RyYWluPC9rZXl3b3JkPjxrZXl3b3JkPk1hcmZhbiBzeW5kcm9tZTwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsIDE8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1

LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMwOTc3NzgzPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8zMDk3Nzc4MzwvdXJsPjx1cmw+aHR0cHM6Ly9hY2FkZW1pYy5vdXAuY29tL2V1cmhl

YXJ0ai9hcnRpY2xlLWFic3RyYWN0LzQwLzI1LzIwNDcvNTQ0ODg4MT9yZWRpcmVjdGVkRnJvbT1m

dWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTA5My9ldXJoZWFydGovZWh6MTkxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3Jl

Y29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 33 Higher strain rates were associated with more rapid aortic expansion and appeared to predict clinical outcomes. If proximal aortic strain can be shown to be reproducible and if these findings are replicated in larger cohorts, this may help to inform the need for, and timing of, surgery in patients with Marfan syndrome.Pregnancy is associated with a spectacularly increased risk of aortic dissection (AD) in patients with Marfan syndrome compared to the normal population, particularly in the post-partum state. Oxytocin levels have been implicated in the pathogenesis of peri-partum AD in patients with Marfan syndrome. Antagonism of oxytocin signalling in a mouse model of Marfan syndrome protected pregnant mice from AD. ADDIN EN.CITE <EndNote><Cite><Author>Habashi</Author><Year>2019</Year><RecNum>4109</RecNum><DisplayText><style face="superscript">34</style></DisplayText><record><rec-number>4109</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1569937789">4109</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Habashi, J. P.</author><author>MacFarlane, E. G.</author><author>Bagirzadeh, R.</author><author>Bowen, C.</author><author>Huso, N.</author><author>Chen, Y.</author><author>Bedja, D.</author><author>Creamer, T. J.</author><author>Rykiel, G.</author><author>Manning, M.</author><author>Huso, D.</author><author>Dietz, H. C.</author></authors></contributors><auth-address>Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA.&#xD;Center for Medical Genetics, Johns Hopkins University, Baltimore, MD 21287, USA.&#xD;Division of Comparative Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.&#xD;Department of Surgery, Johns Hopkins University, Baltimore, MD 21287, USA.&#xD;Department of Cancer Biology, University of Toledo College of Medicine, Toledo, OH 43614, USA.&#xD;Center for Medical Genetics, Johns Hopkins University, Baltimore, MD 21287, USA. hdietz@jhmi.edu.&#xD;Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.</auth-address><titles><title>Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome</title><secondary-title>Sci Transl Med</secondary-title></titles><volume>11</volume><number>490</number><dates><year>2019</year><pub-dates><date>May 1</date></pub-dates></dates><isbn>1946-6242 (Electronic)&#xD;1946-6234 (Linking)</isbn><accession-num>31043570</accession-num><urls><related-urls><url> The implications of this finding require clinical studies.Aortic dissection is accompanied by complex flow patterns in the true and often the false lumen. Better understanding of the dynamics of this process may help to explain the widely differing behaviour of ADs seen over the long term. Recent insights into this process have become available from detailed study of flow patterns using echo Doppler. This approach allows the systematic identification of categorisation of abnormal flow patterns, and the potential for prognostic implications is discussed (Figure 4B). ADDIN EN.CITE <EndNote><Cite><Author>Desai</Author><Year>2019</Year><RecNum>4092</RecNum><DisplayText><style face="superscript">35</style></DisplayText><record><rec-number>4092</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1569929744">4092</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Desai, D.</author><author>Miranda, W.</author><author>Connolly, H.</author><author>Tajik, A. J.</author></authors></contributors><auth-address>Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke&apos;s Medical Centers, University of Wisconsin School of Medicine and Public Health, 2801 W. Kinnickinnic River Parkway, Ste 840, Milwaukee, WI, USA.&#xD;Department of Cardiovascular Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.</auth-address><titles><title>Flow dynamics in the false lumen in distal aorta following surgery for type A aortic dissection</title><secondary-title>Eur Heart J</secondary-title></titles><pages>561</pages><volume>40</volume><number>6</number><dates><year>2019</year><pub-dates><date>Feb 7</date></pub-dates></dates><isbn>1522-9645 (Electronic)&#xD;0195-668X (Linking)</isbn><accession-num>30085046</accession-num><urls><related-urls><url> The optimal management of descending thoracic aortic aneurysms is controversial. A recent US study, based on a retrospective, propensity-adjusted population of Medicare beneficiaries found lower perioperative mortality in patients undergoing thoracic endovascular aortic repair (TEVAR) compared to open repair (particularly when low volume centres were evaluated) but with a higher risk of re-intervention. Overall mortality appeared to be lower in those undergoing TEVAR.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGl1PC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQxMTE8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4z

Njwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQxMTE8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2VzMnI3

NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTkzNzg2MCI+NDExMTwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q2hpdSwgUC48L2F1dGhvcj48YXV0aG9yPkdv

bGRzdG9uZSwgQS4gQi48L2F1dGhvcj48YXV0aG9yPlNjaGFmZmVyLCBKLiBNLjwvYXV0aG9yPjxh

dXRob3I+TGluZ2FsYSwgQi48L2F1dGhvcj48YXV0aG9yPk1pbGxlciwgRC4gQy48L2F1dGhvcj48

YXV0aG9yPk1pdGNoZWxsLCBSLiBTLjwvYXV0aG9yPjxhdXRob3I+V29vLCBZLiBKLjwvYXV0aG9y

PjxhdXRob3I+RmlzY2hiZWluLCBNLiBQLjwvYXV0aG9yPjxhdXRob3I+RGFrZSwgTS4gRC48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9m

IENhcmRpb3Rob3JhY2ljIFN1cmdlcnksIFN0YW5mb3JkIFVuaXZlcnNpdHksIFNjaG9vbCBvZiBN

ZWRpY2luZSwgU3RhbmZvcmQsIENhbGlmb3JuaWE7IERlcGFydG1lbnQgb2YgSGVhbHRoIGFuZCBS

ZXNlYXJjaCBQb2xpY3ksIFN0YW5mb3JkIFVuaXZlcnNpdHksIFNjaG9vbCBvZiBNZWRpY2luZSwg

U3RhbmZvcmQsIENhbGlmb3JuaWEuJiN4RDtUaGUgSGVhcnQgSG9zcGl0YWwgQmF5bG9yIFBsYW5v

LCBQbGFubywgVGV4YXMuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb3Rob3JhY2ljIFN1cmdlcnks

IFN0YW5mb3JkIFVuaXZlcnNpdHksIFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQsIENhbGlm

b3JuaWEuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb3Rob3JhY2ljIFN1cmdlcnksIFN0YW5mb3Jk

IFVuaXZlcnNpdHksIFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQsIENhbGlmb3JuaWEuIEVs

ZWN0cm9uaWMgYWRkcmVzczogbWRkYWtlQHN0YW5mb3JkLmVkdS48L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5FbmRvdmFzY3VsYXIgVmVyc3VzIE9wZW4gUmVwYWlyIG9mIEludGFjdCBEZXNj

ZW5kaW5nIFRob3JhY2ljIEFvcnRpYyBBbmV1cnlzbXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+

SiBBbSBDb2xsIENhcmRpb2w8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+NjQzLTY1

MTwvcGFnZXM+PHZvbHVtZT43Mzwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5UZXZhcjwva2V5d29yZD48a2V5d29yZD5hb3J0aWMgc3VyZ2VyeTwva2V5d29yZD48

a2V5d29yZD5kZXNjZW5kaW5nIGFvcnRhPC9rZXl3b3JkPjxrZXl3b3JkPmVuZG92YXNjdWxhciBz

dXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPnRob3JhY2ljIGFvcnRhPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWIgMTk8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTU4LTM1OTcgKEVsZWN0cm9uaWMpJiN4RDswNzM1

LTEwOTcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMwNzY1MDI5PC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8zMDc2NTAyOTwvdXJsPjx1cmw+aHR0cHM6Ly93d3cuc2NpZW5jZWRpcmVjdC5jb20v

c2NpZW5jZS9hcnRpY2xlL3BpaS9TMDczNTEwOTcxODM5NDQ3Nj92aWElM0RpaHViPC91cmw+PC9y

ZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzY2NzU0NTg8L2N1c3RvbTI+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5qYWNjLjIwMTguMTAuMDg2PC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGl1PC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj

TnVtPjQxMTE8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4z

Njwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQxMTE8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2VzMnI3

NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTkzNzg2MCI+NDExMTwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q2hpdSwgUC48L2F1dGhvcj48YXV0aG9yPkdv

bGRzdG9uZSwgQS4gQi48L2F1dGhvcj48YXV0aG9yPlNjaGFmZmVyLCBKLiBNLjwvYXV0aG9yPjxh

dXRob3I+TGluZ2FsYSwgQi48L2F1dGhvcj48YXV0aG9yPk1pbGxlciwgRC4gQy48L2F1dGhvcj48

YXV0aG9yPk1pdGNoZWxsLCBSLiBTLjwvYXV0aG9yPjxhdXRob3I+V29vLCBZLiBKLjwvYXV0aG9y

PjxhdXRob3I+RmlzY2hiZWluLCBNLiBQLjwvYXV0aG9yPjxhdXRob3I+RGFrZSwgTS4gRC48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9m

IENhcmRpb3Rob3JhY2ljIFN1cmdlcnksIFN0YW5mb3JkIFVuaXZlcnNpdHksIFNjaG9vbCBvZiBN

ZWRpY2luZSwgU3RhbmZvcmQsIENhbGlmb3JuaWE7IERlcGFydG1lbnQgb2YgSGVhbHRoIGFuZCBS

ZXNlYXJjaCBQb2xpY3ksIFN0YW5mb3JkIFVuaXZlcnNpdHksIFNjaG9vbCBvZiBNZWRpY2luZSwg

U3RhbmZvcmQsIENhbGlmb3JuaWEuJiN4RDtUaGUgSGVhcnQgSG9zcGl0YWwgQmF5bG9yIFBsYW5v

LCBQbGFubywgVGV4YXMuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb3Rob3JhY2ljIFN1cmdlcnks

IFN0YW5mb3JkIFVuaXZlcnNpdHksIFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQsIENhbGlm

b3JuaWEuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb3Rob3JhY2ljIFN1cmdlcnksIFN0YW5mb3Jk

IFVuaXZlcnNpdHksIFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQsIENhbGlmb3JuaWEuIEVs

ZWN0cm9uaWMgYWRkcmVzczogbWRkYWtlQHN0YW5mb3JkLmVkdS48L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5FbmRvdmFzY3VsYXIgVmVyc3VzIE9wZW4gUmVwYWlyIG9mIEludGFjdCBEZXNj

ZW5kaW5nIFRob3JhY2ljIEFvcnRpYyBBbmV1cnlzbXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+

SiBBbSBDb2xsIENhcmRpb2w8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+NjQzLTY1

MTwvcGFnZXM+PHZvbHVtZT43Mzwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5UZXZhcjwva2V5d29yZD48a2V5d29yZD5hb3J0aWMgc3VyZ2VyeTwva2V5d29yZD48

a2V5d29yZD5kZXNjZW5kaW5nIGFvcnRhPC9rZXl3b3JkPjxrZXl3b3JkPmVuZG92YXNjdWxhciBz

dXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPnRob3JhY2ljIGFvcnRhPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWIgMTk8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTU4LTM1OTcgKEVsZWN0cm9uaWMpJiN4RDswNzM1

LTEwOTcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMwNzY1MDI5PC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8zMDc2NTAyOTwvdXJsPjx1cmw+aHR0cHM6Ly93d3cuc2NpZW5jZWRpcmVjdC5jb20v

c2NpZW5jZS9hcnRpY2xlL3BpaS9TMDczNTEwOTcxODM5NDQ3Nj92aWElM0RpaHViPC91cmw+PC9y

ZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzY2NzU0NTg8L2N1c3RvbTI+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5qYWNjLjIwMTguMTAuMDg2PC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 36 The odds of perioperative mortality were greater for open surgical repair and depended on the centre volume: high-volume centre, odds ratio (OR): 1.97 (95%CI 1.5 – 2.6); low-volume centre, OR: 3.62 (95%CI 2.9 – 4.5). The restricted mean survival time difference favoured TEVAR at 9 years,?-209?days (95%CI?-299 –?-120 days) for open surgical repair. Risk of re-intervention was lower for open surgical repair, hazard ratio: 0.40 (95%CI 0.34 – 0.60).In the last ESC guidelines on the management of aortic diseases,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FcmJlbDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

Y051bT40MTA2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

MzE8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA2PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc2NzIiPjQxMDY8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkVyYmVsLCBSLjwvYXV0aG9yPjxhdXRob3I+

QWJveWFucywgVi48L2F1dGhvcj48YXV0aG9yPkJvaWxlYXUsIEMuPC9hdXRob3I+PGF1dGhvcj5C

b3Nzb25lLCBFLjwvYXV0aG9yPjxhdXRob3I+QmFydG9sb21lbywgUi4gRC48L2F1dGhvcj48YXV0

aG9yPkVnZ2VicmVjaHQsIEguPC9hdXRob3I+PGF1dGhvcj5FdmFuZ2VsaXN0YSwgQS48L2F1dGhv

cj48YXV0aG9yPkZhbGssIFYuPC9hdXRob3I+PGF1dGhvcj5GcmFuaywgSC48L2F1dGhvcj48YXV0

aG9yPkdhZW1wZXJsaSwgTy48L2F1dGhvcj48YXV0aG9yPkdyYWJlbndvZ2VyLCBNLjwvYXV0aG9y

PjxhdXRob3I+SGF2ZXJpY2gsIEEuPC9hdXRob3I+PGF1dGhvcj5JdW5nLCBCLjwvYXV0aG9yPjxh

dXRob3I+TWFub2xpcywgQS4gSi48L2F1dGhvcj48YXV0aG9yPk1laWpib29tLCBGLjwvYXV0aG9y

PjxhdXRob3I+TmllbmFiZXIsIEMuIEEuPC9hdXRob3I+PGF1dGhvcj5Sb2ZmaSwgTS48L2F1dGhv

cj48YXV0aG9yPlJvdXNzZWF1LCBILjwvYXV0aG9yPjxhdXRob3I+U2VjaHRlbSwgVS48L2F1dGhv

cj48YXV0aG9yPlNpcm5lcywgUC4gQS48L2F1dGhvcj48YXV0aG9yPkFsbG1lbiwgUi4gUy48L2F1

dGhvcj48YXV0aG9yPlZyaW50cywgQy4gSi48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIENvbW1p

dHRlZSBmb3IgUHJhY3RpY2UgR3VpZGVsaW5lczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE0IEVTQyBHdWlkZWxpbmVzIG9uIHRoZSBkaWFnbm9zaXMg

YW5kIHRyZWF0bWVudCBvZiBhb3J0aWMgZGlzZWFzZXM6IERvY3VtZW50IGNvdmVyaW5nIGFjdXRl

IGFuZCBjaHJvbmljIGFvcnRpYyBkaXNlYXNlcyBvZiB0aGUgdGhvcmFjaWMgYW5kIGFiZG9taW5h

bCBhb3J0YSBvZiB0aGUgYWR1bHQuIFRoZSBUYXNrIEZvcmNlIGZvciB0aGUgRGlhZ25vc2lzIGFu

ZCBUcmVhdG1lbnQgb2YgQW9ydGljIERpc2Vhc2VzIG9mIHRoZSBFdXJvcGVhbiBTb2NpZXR5IG9m

IENhcmRpb2xvZ3kgKEVTQyk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3Nl

Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+Mjg3My05MjY8L3BhZ2VzPjx2b2x1bWU+MzU8

L3ZvbHVtZT48bnVtYmVyPjQxPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIERpc2Vh

c2U8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+QW5ldXJ5

c20sIERpc3NlY3RpbmcvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+QW5ldXJ5

c20sIEZhbHNlL2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPipBb3J0YSwgQWJk

b21pbmFsL2luanVyaWVzPC9rZXl3b3JkPjxrZXl3b3JkPipBb3J0YSwgVGhvcmFjaWMvaW5qdXJp

ZXM8L2tleXdvcmQ+PGtleXdvcmQ+QW9ydGljIERpc2Vhc2VzL2NvbXBsaWNhdGlvbnMvKmRpYWdu

b3Npcy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5Bb3J0aWMgVmFsdmU8L2tleXdvcmQ+PGtl

eXdvcmQ+QXRoZXJvc2NsZXJvc2lzL2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3Jk

PkNhcmRpb3Zhc2N1bGFyIEFnZW50cy90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+

Q2xpbmljYWwgTGFib3JhdG9yeSBUZWNobmlxdWVzL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+

RGlhZ25vc3RpYyBJbWFnaW5nL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RWFybHkgRGlhZ25v

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkVuZG92YXNjdWxhciBQcm9jZWR1cmVzL21ldGhvZHM8L2tl

eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgRGlzZWFzZXMs

IEluYm9ybi9jb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPkhlYXJ0IERlZmVjdHMsIENv

bmdlbml0YWwvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcnQgVmFsdmUg

RGlzZWFzZXMvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvbWEvZGlh

Z25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3Jk

PkxvbmctVGVybSBDYXJlL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48

a2V5d29yZD5OZW9wbGFzbXMsIFZhc2N1bGFyIFRpc3N1ZS9kaWFnbm9zaXMvdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5QaHlzaWNhbCBFeGFtaW5hdGlvbi9tZXRob2RzPC9rZXl3b3JkPjxrZXl3

b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5WYXNjdWxhciBDYWxjaWZpY2F0aW9u

L2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlZhc2N1bGFyIFN0aWZmbmVzcy9w

aHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlZhc2N1bGFyIFN1cmdpY2FsIFByb2NlZHVyZXMv

bWV0aG9kczwva2V5d29yZD48a2V5d29yZD5BYmRvbWluYWwgYW9ydGljIGFuZXVyeXNtPC9rZXl3

b3JkPjxrZXl3b3JkPkFjdXRlIGFvcnRpYyBzeW5kcm9tZTwva2V5d29yZD48a2V5d29yZD5Bb3J0

aWMgYW5ldXJ5c208L2tleXdvcmQ+PGtleXdvcmQ+QW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxr

ZXl3b3JkPkFvcnRpYyBkaXNzZWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkFvcnRpYyB0dW1vdXJz

PC9rZXl3b3JkPjxrZXl3b3JkPkFvcnRpdGlzPC9rZXl3b3JkPjxrZXl3b3JkPkNvbmdlbml0YWwg

YW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxrZXl3b3JkPkVuZG92YXNjdWxhciB0aGVyYXB5PC9r

ZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgYW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxrZXl3b3Jk

Pkd1aWRlbGluZXM8L2tleXdvcmQ+PGtleXdvcmQ+SW50cmFtdXJhbCBoYWVtYXRvbWE8L2tleXdv

cmQ+PGtleXdvcmQ+UGVuZXRyYXRpbmcgYW9ydGljIHVsY2VyPC9rZXl3b3JkPjxrZXl3b3JkPlRo

cm9tYm9lbWJvbGljIGFvcnRpYyBkaXNlYXNlczwva2V5d29yZD48a2V5d29yZD5UcmF1bWF0aWMg

YW9ydGljIGluanVyeTwva2V5d29yZD48a2V5d29yZD5WYXNjdWxhciBzdXJnZXJ5PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3Yg

MTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjItOTY0NSAoRWxlY3Ryb25pYykm

I3hEOzAxOTUtNjY4WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjUxNzMzNDA8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzI1MTczMzQwPC91cmw+PHVybD5odHRwczovL3dhdGVybWFyay5zaWx2

ZXJjaGFpci5jb20vZWh1MjgxLnBkZj90b2tlbj1BUUVDQUhpMjA4QkU0OU9vYW45a2toV19FcmN5

N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQW4wd2dnSjVCZ2txaGtpRzl3MEJCd2FnZ2dKcU1JSUNa

Z0lCQURDQ0FsOEdDU3FHU0liM0RRRUhBVEFlQmdsZ2hrZ0JaUU1FQVM0d0VRUU1Cd2c1LVE5YW5V

QThJQkdIQWdFUWdJSUNNQmFVTUd4WjlJOFdNd0lOQ3llNmliTEVhTlh4NFp5YXRrZzdaTDdCUVpQ

MUtyR083MmVoM1ZZZnJhQWNBR2xiUFNoS3phdWNFYk9Gb3pQV08tazVYVzZFRE9oWF9lSWoxNUZJ

bFFOQzBOV3ZzRWFDWnNVc2o5aWJqbmN2dkViY09KVXBVYWQxQnJnT1lncmpXREhxNEU1VjdRdGlj

TnJ4QkRoMkw1cV9sWnZTa2hrN0V2UU5hc3NMb0VwbjNYbERhbHpJWHlIS2Z6OFlHNUFjTWxtcGxm

dVBIeUtSN2ZFR0pRc2xVbE1rUXVjb3ppeHB1Q1FhTEIxenFJTjB5MENVUWRZeWlabVhfaHI5bmJL

cWh3ZjRXNldCT19FU3BrS2RzWDgtVVZPbVA1M2w2UnllbWNLblU1STJJZWJUUnh0Yk9DamJxa0g3

VUNUWXR2VDVQQzlZR1I2cGpfNEJseU1ZcEotTlZVMmNXTU1FZHlteDYzRHFYSVZWXzMySU1UWVJj

OC1WVW84aG1VWU9UWVJFWlV6MmIzVmdoa21BcFlPdEI1M1ozMWJ2R0xSc29VMXFQS2pITXlMQlh2

elpJc3Q3Y2Q5cWtFZ3drVG1PN1cwSjJWT25XU1JlTERwR3U2dnlfNlVtMFEzQzlwZ3hKR0wyMUxC

Y0RabW41VWkybWdJd2xBb3pmZGpIRUdwbFVoZ1prVEk0UVktM3ZfSjFtOEo5SGkwV1N1dmFEeFVB

WlJpMktfQXlRbWxJZ1BRTWZ2X28tQk9wSVZIY1h3ME9VaF91bEdUVTZ0ZHdxNXQ4STAzenNxU2M5

TEdsQV9wUk5naWJ4Q0hmNW9HSjZXVVAzVEozV0daM1NYMkZncVBidEtob2lBLWN2VGJRNlFSR2dX

TmhnZ05jRkotTzlROE5WMG9ES3I4aUpnSFlxTXNpV3lGVnZfQ0ZEUk9YMEdLOWtvOTduRENlUVZB

a2Q0OUh2cHBLNlR2c0U3d0ZUcWFlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHUyODE8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FcmJlbDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

Y051bT40MTA2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

MzE8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA2PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc2NzIiPjQxMDY8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkVyYmVsLCBSLjwvYXV0aG9yPjxhdXRob3I+

QWJveWFucywgVi48L2F1dGhvcj48YXV0aG9yPkJvaWxlYXUsIEMuPC9hdXRob3I+PGF1dGhvcj5C

b3Nzb25lLCBFLjwvYXV0aG9yPjxhdXRob3I+QmFydG9sb21lbywgUi4gRC48L2F1dGhvcj48YXV0

aG9yPkVnZ2VicmVjaHQsIEguPC9hdXRob3I+PGF1dGhvcj5FdmFuZ2VsaXN0YSwgQS48L2F1dGhv

cj48YXV0aG9yPkZhbGssIFYuPC9hdXRob3I+PGF1dGhvcj5GcmFuaywgSC48L2F1dGhvcj48YXV0

aG9yPkdhZW1wZXJsaSwgTy48L2F1dGhvcj48YXV0aG9yPkdyYWJlbndvZ2VyLCBNLjwvYXV0aG9y

PjxhdXRob3I+SGF2ZXJpY2gsIEEuPC9hdXRob3I+PGF1dGhvcj5JdW5nLCBCLjwvYXV0aG9yPjxh

dXRob3I+TWFub2xpcywgQS4gSi48L2F1dGhvcj48YXV0aG9yPk1laWpib29tLCBGLjwvYXV0aG9y

PjxhdXRob3I+TmllbmFiZXIsIEMuIEEuPC9hdXRob3I+PGF1dGhvcj5Sb2ZmaSwgTS48L2F1dGhv

cj48YXV0aG9yPlJvdXNzZWF1LCBILjwvYXV0aG9yPjxhdXRob3I+U2VjaHRlbSwgVS48L2F1dGhv

cj48YXV0aG9yPlNpcm5lcywgUC4gQS48L2F1dGhvcj48YXV0aG9yPkFsbG1lbiwgUi4gUy48L2F1

dGhvcj48YXV0aG9yPlZyaW50cywgQy4gSi48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIENvbW1p

dHRlZSBmb3IgUHJhY3RpY2UgR3VpZGVsaW5lczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48dGl0bGVzPjx0aXRsZT4yMDE0IEVTQyBHdWlkZWxpbmVzIG9uIHRoZSBkaWFnbm9zaXMg

YW5kIHRyZWF0bWVudCBvZiBhb3J0aWMgZGlzZWFzZXM6IERvY3VtZW50IGNvdmVyaW5nIGFjdXRl

IGFuZCBjaHJvbmljIGFvcnRpYyBkaXNlYXNlcyBvZiB0aGUgdGhvcmFjaWMgYW5kIGFiZG9taW5h

bCBhb3J0YSBvZiB0aGUgYWR1bHQuIFRoZSBUYXNrIEZvcmNlIGZvciB0aGUgRGlhZ25vc2lzIGFu

ZCBUcmVhdG1lbnQgb2YgQW9ydGljIERpc2Vhc2VzIG9mIHRoZSBFdXJvcGVhbiBTb2NpZXR5IG9m

IENhcmRpb2xvZ3kgKEVTQyk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3Nl

Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+Mjg3My05MjY8L3BhZ2VzPjx2b2x1bWU+MzU8

L3ZvbHVtZT48bnVtYmVyPjQxPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIERpc2Vh

c2U8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+QW5ldXJ5

c20sIERpc3NlY3RpbmcvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+QW5ldXJ5

c20sIEZhbHNlL2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPipBb3J0YSwgQWJk

b21pbmFsL2luanVyaWVzPC9rZXl3b3JkPjxrZXl3b3JkPipBb3J0YSwgVGhvcmFjaWMvaW5qdXJp

ZXM8L2tleXdvcmQ+PGtleXdvcmQ+QW9ydGljIERpc2Vhc2VzL2NvbXBsaWNhdGlvbnMvKmRpYWdu

b3Npcy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5Bb3J0aWMgVmFsdmU8L2tleXdvcmQ+PGtl

eXdvcmQ+QXRoZXJvc2NsZXJvc2lzL2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3Jk

PkNhcmRpb3Zhc2N1bGFyIEFnZW50cy90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+

Q2xpbmljYWwgTGFib3JhdG9yeSBUZWNobmlxdWVzL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+

RGlhZ25vc3RpYyBJbWFnaW5nL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RWFybHkgRGlhZ25v

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkVuZG92YXNjdWxhciBQcm9jZWR1cmVzL21ldGhvZHM8L2tl

eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgRGlzZWFzZXMs

IEluYm9ybi9jb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPkhlYXJ0IERlZmVjdHMsIENv

bmdlbml0YWwvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcnQgVmFsdmUg

RGlzZWFzZXMvZGlhZ25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvbWEvZGlh

Z25vc2lzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3Jk

PkxvbmctVGVybSBDYXJlL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48

a2V5d29yZD5OZW9wbGFzbXMsIFZhc2N1bGFyIFRpc3N1ZS9kaWFnbm9zaXMvdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5QaHlzaWNhbCBFeGFtaW5hdGlvbi9tZXRob2RzPC9rZXl3b3JkPjxrZXl3

b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5WYXNjdWxhciBDYWxjaWZpY2F0aW9u

L2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlZhc2N1bGFyIFN0aWZmbmVzcy9w

aHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlZhc2N1bGFyIFN1cmdpY2FsIFByb2NlZHVyZXMv

bWV0aG9kczwva2V5d29yZD48a2V5d29yZD5BYmRvbWluYWwgYW9ydGljIGFuZXVyeXNtPC9rZXl3

b3JkPjxrZXl3b3JkPkFjdXRlIGFvcnRpYyBzeW5kcm9tZTwva2V5d29yZD48a2V5d29yZD5Bb3J0

aWMgYW5ldXJ5c208L2tleXdvcmQ+PGtleXdvcmQ+QW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxr

ZXl3b3JkPkFvcnRpYyBkaXNzZWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkFvcnRpYyB0dW1vdXJz

PC9rZXl3b3JkPjxrZXl3b3JkPkFvcnRpdGlzPC9rZXl3b3JkPjxrZXl3b3JkPkNvbmdlbml0YWwg

YW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxrZXl3b3JkPkVuZG92YXNjdWxhciB0aGVyYXB5PC9r

ZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgYW9ydGljIGRpc2Vhc2VzPC9rZXl3b3JkPjxrZXl3b3Jk

Pkd1aWRlbGluZXM8L2tleXdvcmQ+PGtleXdvcmQ+SW50cmFtdXJhbCBoYWVtYXRvbWE8L2tleXdv

cmQ+PGtleXdvcmQ+UGVuZXRyYXRpbmcgYW9ydGljIHVsY2VyPC9rZXl3b3JkPjxrZXl3b3JkPlRo

cm9tYm9lbWJvbGljIGFvcnRpYyBkaXNlYXNlczwva2V5d29yZD48a2V5d29yZD5UcmF1bWF0aWMg

YW9ydGljIGluanVyeTwva2V5d29yZD48a2V5d29yZD5WYXNjdWxhciBzdXJnZXJ5PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3Yg

MTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjItOTY0NSAoRWxlY3Ryb25pYykm

I3hEOzAxOTUtNjY4WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjUxNzMzNDA8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzI1MTczMzQwPC91cmw+PHVybD5odHRwczovL3dhdGVybWFyay5zaWx2

ZXJjaGFpci5jb20vZWh1MjgxLnBkZj90b2tlbj1BUUVDQUhpMjA4QkU0OU9vYW45a2toV19FcmN5

N0RtM1pMXzlDZjNxZktBYzQ4NXlzZ0FBQW4wd2dnSjVCZ2txaGtpRzl3MEJCd2FnZ2dKcU1JSUNa

Z0lCQURDQ0FsOEdDU3FHU0liM0RRRUhBVEFlQmdsZ2hrZ0JaUU1FQVM0d0VRUU1Cd2c1LVE5YW5V

QThJQkdIQWdFUWdJSUNNQmFVTUd4WjlJOFdNd0lOQ3llNmliTEVhTlh4NFp5YXRrZzdaTDdCUVpQ

MUtyR083MmVoM1ZZZnJhQWNBR2xiUFNoS3phdWNFYk9Gb3pQV08tazVYVzZFRE9oWF9lSWoxNUZJ

bFFOQzBOV3ZzRWFDWnNVc2o5aWJqbmN2dkViY09KVXBVYWQxQnJnT1lncmpXREhxNEU1VjdRdGlj

TnJ4QkRoMkw1cV9sWnZTa2hrN0V2UU5hc3NMb0VwbjNYbERhbHpJWHlIS2Z6OFlHNUFjTWxtcGxm

dVBIeUtSN2ZFR0pRc2xVbE1rUXVjb3ppeHB1Q1FhTEIxenFJTjB5MENVUWRZeWlabVhfaHI5bmJL

cWh3ZjRXNldCT19FU3BrS2RzWDgtVVZPbVA1M2w2UnllbWNLblU1STJJZWJUUnh0Yk9DamJxa0g3

VUNUWXR2VDVQQzlZR1I2cGpfNEJseU1ZcEotTlZVMmNXTU1FZHlteDYzRHFYSVZWXzMySU1UWVJj

OC1WVW84aG1VWU9UWVJFWlV6MmIzVmdoa21BcFlPdEI1M1ozMWJ2R0xSc29VMXFQS2pITXlMQlh2

elpJc3Q3Y2Q5cWtFZ3drVG1PN1cwSjJWT25XU1JlTERwR3U2dnlfNlVtMFEzQzlwZ3hKR0wyMUxC

Y0RabW41VWkybWdJd2xBb3pmZGpIRUdwbFVoZ1prVEk0UVktM3ZfSjFtOEo5SGkwV1N1dmFEeFVB

WlJpMktfQXlRbWxJZ1BRTWZ2X28tQk9wSVZIY1h3ME9VaF91bEdUVTZ0ZHdxNXQ4STAzenNxU2M5

TEdsQV9wUk5naWJ4Q0hmNW9HSjZXVVAzVEozV0daM1NYMkZncVBidEtob2lBLWN2VGJRNlFSR2dX

TmhnZ05jRkotTzlROE5WMG9ES3I4aUpnSFlxTXNpV3lGVnZfQ0ZEUk9YMEdLOWtvOTduRENlUVZB

a2Q0OUh2cHBLNlR2c0U3d0ZUcWFlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHUyODE8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA 31 both open surgery and endovascular aneurysm repair (EVAR) therapy received class I recommendation, based on several head-to-head trials enrolling patients with suitable anatomy for both options. While, in the short term, EVAR was associated with less mortality, this difference was gradually annihilated over time, while in turn, EVAR requested repeated (irradiating) imaging and re-interventions for endoleaks. The results of very long-term follow-up (14 years) of the Open Versus Endovascular Repair (OVER) trialPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWRlcmxlPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjQxMTI8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4zNzwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQxMTI8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2Vz

MnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTkzNzg4OSI+NDExMjwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TGVkZXJsZSwgRi4gQS48L2F1dGhvcj48

YXV0aG9yPkt5cmlha2lkZXMsIFQuIEMuPC9hdXRob3I+PGF1dGhvcj5TdHJvdXBlLCBLLiBULjwv

YXV0aG9yPjxhdXRob3I+RnJlaXNjaGxhZywgSi4gQS48L2F1dGhvcj48YXV0aG9yPlBhZGJlcmcs

IEYuIFQuLCBKci48L2F1dGhvcj48YXV0aG9yPk1hdHN1bXVyYSwgSi4gUy48L2F1dGhvcj48YXV0

aG9yPkh1bywgWi48L2F1dGhvcj48YXV0aG9yPkpvaG5zb24sIEcuIFIuPC9hdXRob3I+PGF1dGhv

cj5PdmVyIFZldGVyYW5zIEFmZmFpcnMgQ29vcGVyYXRpdmUgU3R1ZHkgR3JvdXA8L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Gcm9tIHRoZSBWZXRlcmFucyBB

ZmZhaXJzIChWQSkgTWVkaWNhbCBDZW50ZXIsIE1pbm5lYXBvbGlzIChGLkEuTC4pOyBWQSBIZWFs

dGhjYXJlIFN5c3RlbSwgV2VzdCBIYXZlbiwgQ1QgKFQuQy5LLiwgRy5SLkouKTsgRWR3YXJkIEhp

bmVzLCBKci4gVkEgSG9zcGl0YWwsIEhpbmVzLCBJTCAoSy5ULlMuLCBaLkguKTsgV2FrZSBGb3Jl

c3QgQmFwdGlzdCBIZWFsdGgsIFdpbnN0b24tU2FsZW0sIE5DIChKLkEuRi4pOyBWQSBNZWRpY2Fs

IENlbnRlciwgRWFzdCBPcmFuZ2UsIE5KIChGLlQuUC4pOyBhbmQgVkEgTWVkaWNhbCBDZW50ZXIs

IE1hZGlzb24sIFdJIChKLlMuTS4pLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk9wZW4g

dmVyc3VzIEVuZG92YXNjdWxhciBSZXBhaXIgb2YgQWJkb21pbmFsIEFvcnRpYyBBbmV1cnlzbTwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5OIEVuZ2wgSiBNZWQ8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGFnZXM+MjEyNi0yMTM1PC9wYWdlcz48dm9sdW1lPjM4MDwvdm9sdW1lPjxudW1iZXI+

MjI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5Bb3J0

YSwgQWJkb21pbmFsLypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPkFvcnRpYyBBbmV1cnlzbSwg

QWJkb21pbmFsL21vcnRhbGl0eS8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5DYXVzZSBvZiBE

ZWF0aDwva2V5d29yZD48a2V5d29yZD5FbGVjdGl2ZSBTdXJnaWNhbCBQcm9jZWR1cmVzL21ldGhv

ZHM8L2tleXdvcmQ+PGtleXdvcmQ+KkVuZG92YXNjdWxhciBQcm9jZWR1cmVzL21ldGhvZHM8L2tl

eXdvcmQ+PGtleXdvcmQ+Rm9sbG93LVVwIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z

PC9rZXl3b3JkPjxrZXl3b3JkPkthcGxhbi1NZWllciBFc3RpbWF0ZTwva2V5d29yZD48a2V5d29y

ZD5Qb3N0b3BlcmF0aXZlIENvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50

IE91dGNvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHVi

LWRhdGVzPjxkYXRlPk1heSAzMDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMt

NDQwNiAoRWxlY3Ryb25pYykmI3hEOzAwMjgtNDc5MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MzExNDE2MzQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMxMTQxNjM0PC91cmw+PHVybD5odHRw

czovL3d3dy5uZWptLm9yZy9kb2kvcGRmLzEwLjEwNTYvTkVKTW9hMTcxNTk1NT9hcnRpY2xlVG9v

bHM9dHJ1ZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTA1Ni9ORUpNb2ExNzE1OTU1PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWRlcmxlPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjQxMTI8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4zNzwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQxMTI8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2Vz

MnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTkzNzg4OSI+NDExMjwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TGVkZXJsZSwgRi4gQS48L2F1dGhvcj48

YXV0aG9yPkt5cmlha2lkZXMsIFQuIEMuPC9hdXRob3I+PGF1dGhvcj5TdHJvdXBlLCBLLiBULjwv

YXV0aG9yPjxhdXRob3I+RnJlaXNjaGxhZywgSi4gQS48L2F1dGhvcj48YXV0aG9yPlBhZGJlcmcs

IEYuIFQuLCBKci48L2F1dGhvcj48YXV0aG9yPk1hdHN1bXVyYSwgSi4gUy48L2F1dGhvcj48YXV0

aG9yPkh1bywgWi48L2F1dGhvcj48YXV0aG9yPkpvaG5zb24sIEcuIFIuPC9hdXRob3I+PGF1dGhv

cj5PdmVyIFZldGVyYW5zIEFmZmFpcnMgQ29vcGVyYXRpdmUgU3R1ZHkgR3JvdXA8L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Gcm9tIHRoZSBWZXRlcmFucyBB

ZmZhaXJzIChWQSkgTWVkaWNhbCBDZW50ZXIsIE1pbm5lYXBvbGlzIChGLkEuTC4pOyBWQSBIZWFs

dGhjYXJlIFN5c3RlbSwgV2VzdCBIYXZlbiwgQ1QgKFQuQy5LLiwgRy5SLkouKTsgRWR3YXJkIEhp

bmVzLCBKci4gVkEgSG9zcGl0YWwsIEhpbmVzLCBJTCAoSy5ULlMuLCBaLkguKTsgV2FrZSBGb3Jl

c3QgQmFwdGlzdCBIZWFsdGgsIFdpbnN0b24tU2FsZW0sIE5DIChKLkEuRi4pOyBWQSBNZWRpY2Fs

IENlbnRlciwgRWFzdCBPcmFuZ2UsIE5KIChGLlQuUC4pOyBhbmQgVkEgTWVkaWNhbCBDZW50ZXIs

IE1hZGlzb24sIFdJIChKLlMuTS4pLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk9wZW4g

dmVyc3VzIEVuZG92YXNjdWxhciBSZXBhaXIgb2YgQWJkb21pbmFsIEFvcnRpYyBBbmV1cnlzbTwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5OIEVuZ2wgSiBNZWQ8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGFnZXM+MjEyNi0yMTM1PC9wYWdlcz48dm9sdW1lPjM4MDwvdm9sdW1lPjxudW1iZXI+

MjI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5Bb3J0

YSwgQWJkb21pbmFsLypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPkFvcnRpYyBBbmV1cnlzbSwg

QWJkb21pbmFsL21vcnRhbGl0eS8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5DYXVzZSBvZiBE

ZWF0aDwva2V5d29yZD48a2V5d29yZD5FbGVjdGl2ZSBTdXJnaWNhbCBQcm9jZWR1cmVzL21ldGhv

ZHM8L2tleXdvcmQ+PGtleXdvcmQ+KkVuZG92YXNjdWxhciBQcm9jZWR1cmVzL21ldGhvZHM8L2tl

eXdvcmQ+PGtleXdvcmQ+Rm9sbG93LVVwIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z

PC9rZXl3b3JkPjxrZXl3b3JkPkthcGxhbi1NZWllciBFc3RpbWF0ZTwva2V5d29yZD48a2V5d29y

ZD5Qb3N0b3BlcmF0aXZlIENvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50

IE91dGNvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHVi

LWRhdGVzPjxkYXRlPk1heSAzMDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMt

NDQwNiAoRWxlY3Ryb25pYykmI3hEOzAwMjgtNDc5MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MzExNDE2MzQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMxMTQxNjM0PC91cmw+PHVybD5odHRw

czovL3d3dy5uZWptLm9yZy9kb2kvcGRmLzEwLjEwNTYvTkVKTW9hMTcxNTk1NT9hcnRpY2xlVG9v

bHM9dHJ1ZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTA1Ni9ORUpNb2ExNzE1OTU1PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 37 are interesting in that they show no mortality or secondary procedure difference beyond the first years. These results support the recommendations made, although they contrast somehow with long-term results in other trials more in favour of open surgery. It is however noteworthy that most deaths in these patients were not aneurysm-related (only 2.7%, mostly post-operative), and that the first cause of death is cardiovascular, emphasizing the crucial necessity for maximal preventive measures in these patients. Last not least, significant evidence is still lacking in women as they constituted only for <10% of all participants.Cerebrovascular diseaseExcessive arterial pulsatility may contribute to cognitive decline and risk of dementia via damage to the fragile cerebral microcirculation. As part of the Whitehall II studyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGllc2E8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxS

ZWNOdW0+NDA3ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi

PjM4PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA3ODwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMy

cjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MjUxODU1Ij40MDc4PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DaGllc2EsIFMuIFQuPC9hdXRob3I+PGF1

dGhvcj5NYXNpLCBTLjwvYXV0aG9yPjxhdXRob3I+U2hpcGxleSwgTS4gSi48L2F1dGhvcj48YXV0

aG9yPkVsbGlucywgRS4gQS48L2F1dGhvcj48YXV0aG9yPkZyYXNlciwgQS4gRy48L2F1dGhvcj48

YXV0aG9yPkh1Z2hlcywgQS4gRC48L2F1dGhvcj48YXV0aG9yPlBhdGVsLCBSLiBTLjwvYXV0aG9y

PjxhdXRob3I+S2hpciwgQS4gVy48L2F1dGhvcj48YXV0aG9yPkhhbGNveCwgSi4gUC48L2F1dGhv

cj48YXV0aG9yPlNpbmdoLU1hbm91eCwgQS48L2F1dGhvcj48YXV0aG9yPktpdmltYWtpLCBNLjwv

YXV0aG9yPjxhdXRob3I+Q2VsZXJtYWplciwgRC4gUy48L2F1dGhvcj48YXV0aG9yPkRlYW5maWVs

ZCwgSi4gRS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5O

YXRpb25hbCBDZW50cmUgZm9yIENhcmRpb3Zhc2N1bGFyIFByZXZlbnRpb25zIGFuZCBPdXRjb21l

cywgVUNMIEluc3RpdHV0ZSBvZiBDYXJkaW92YXNjdWxhciBTY2llbmNlLCAxIFN0LiBNYXJ0aW4m

YXBvcztzIExlIEdyYW5kLCBMb25kb24sIFVLLiYjeEQ7RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBh

bmQgRXhwZXJpbWVudGFsIE1lZGljaW5lLCBVbml2ZXJzaXRhIGRpIFBpc2EsIEJ1aWxkaW5nIDgs

IFMuIENoaWFyYSBIb3NwaXRhbCwgVmlhIFJvbWEgNjcsIFBpc2EsIEl0YWx5LiYjeEQ7RGVwYXJ0

bWVudCBvZiBFcGlkZW1pb2xvZ3kgYW5kIFB1YmxpYyBIZWFsdGgsIFVDTCwgMS0xOSBUb3JyaW5n

dG9uIFBsYWNlLCBMb25kb24sIFVLLiYjeEQ7SW5zdGl0dXRlIG9mIExpZmUgU2NpZW5jZSwgU3dh

bnNlYSBVbml2ZXJzaXR5IE1lZGljYWwgU2Nob29sLCBTd2Fuc2VhIFVuaXZlcnNpdHksIFNpbmds

ZXRvbiBQYXJrLCBTd2Fuc2VhLCBVSy4mI3hEO1NjaG9vbCBvZiBNZWRpY2luZSwgSGVhdGggUGFy

aywgQ2FyZGlmZiwgVUsuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIFVuaXZlcnNpdHkg

SG9zcGl0YWwgb2YgV2FsZXMsIEhlYXRoIFBhcmssIENhcmRpZmYsIFVLLiYjeEQ7RGVwYXJ0bWVu

dCBvZiBQb3B1bGF0aW9uIFNjaWVuY2UgYW5kIEV4cGVyaW1lbnRhbCBNZWRpY2luZSwgVUNMIElu

c3RpdHV0ZSBvZiBDYXJkaW92YXNjdWxhciBTY2llbmNlLCA2OS03NSBDaGVuaWVzIE1ld3MsIExv

bmRvbiwgVUsuJiN4RDtNZWRpY2FsIFJlc2VhcmNoIENvdW5jaWwgVW5pdCBmb3IgTGlmZWxvbmcg

SGVhbHRoIGFuZCBBZ2VpbmcgYXQgVUNMLCAzMyBCZWRmb3JkIFBsYWNlLCBMb25kb24sIFVLLiYj

eEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBCYXJ0JmFwb3M7cyBIZWFydCBDZW50cmUsIFN0

IEJhcnRob2xvbWV3JmFwb3M7cyBIb3NwaXRhbCwgVyBTbWl0aGZpZWxkLCBMb25kb24sIFVLLiYj

eEQ7QmlvbWVkaWNhbCBFbmdpbmVlcmluZyBSZXNlYXJjaCBUaGVtZSwgQnJ1bmVsIFVuaXZlcnNp

dHkgTG9uZG9uLCBLaW5nc3RvbiBMYW5lLCBVeGJyaWRnZSwgVUsuJiN4RDtJbnNlcm0gVTExNTMs

IEVwaWRlbWlvbG9neSBvZiBBZ2VpbmcgYW5kIE5ldXJvZGVnZW5lcmF0aXZlIERpc2Vhc2VzLCBG

YWN1bHR5IG9mIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIFBhcmlzLCAxMCBBdmVudWUgZGUgVmVy

ZHVuLCBQYXJpcywgRnJhbmNlLiYjeEQ7SGVhcnQgUmVzZWFyY2ggSW5zdGl0dXRlLCBFbGl6YSBT

dHJlZXQsIE5ld3Rvd24sIE5TVywgQXVzdHJhbGlhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPkNhcm90aWQgYXJ0ZXJ5IHdhdmUgaW50ZW5zaXR5IGluIG1pZC0gdG8gbGF0ZS1saWZlIHBy

ZWRpY3RzIGNvZ25pdGl2ZSBkZWNsaW5lOiB0aGUgV2hpdGVoYWxsIElJIHN0dWR5PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBh

Z2VzPjIzMDAtMjMwOTwvcGFnZXM+PHZvbHVtZT40MDwvdm9sdW1lPjxudW1iZXI+Mjg8L251bWJl

cj48a2V5d29yZHM+PGtleXdvcmQ+Q2FyZGlvdmFzY3VsYXIgcmlzayBmYWN0b3JzPC9rZXl3b3Jk

PjxrZXl3b3JkPkNvZ25pdGl2ZSBkZWNsaW5lPC9rZXl3b3JkPjxrZXl3b3JkPldhdmUgaW50ZW5z

aXR5PC9rZXl3b3JkPjxrZXl3b3JkPldoaXRlaGFsbCBJSSBzdHVkeTwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsIDIxPC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5

NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDk1Nzg2MzwvYWNjZXNzaW9u

LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMzA5NTc4NjM8L3VybD48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3Yv

cG1jL2FydGljbGVzL1BNQzY2NDI3MjcvcGRmL2VoejE4OS5wZGY8L3VybD48dXJsPmh0dHBzOi8v

d2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9laHoxODkucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5

T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBbXd3Z2dKb0Jna3Foa2lHOXcw

QkJ3YWdnZ0paTUlJQ1ZRSUJBRENDQWs0R0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3

RVFRTWRWdk15c3NoUXF3XzJsZVJBZ0VRZ0lJQ0g0aFlCa1d6WUxiU1hTX0dfdWFOUV95STRaa0Nx

YXVsc0tDQTFPMmt2Zko0Zy1nY2FaalZwRG8zcDR5bnpud0FGU2lncHZsdXBWdlQ3VE1MWXAxOE03

dVdxSjBkcHI4VEdfcGpycmMyMTIxNV92Ym55MVZ5Qkl0NFMwb09mR3AwZEl0QlFHcWNhSkdRZDc3

OXc0WUo2cGlvZUdkQXpFdk41UHhDb2N3UWtCMWVzNjIyUlFDSEp3RVFnZ2k1NWUwMC1JNEhvZ3dX

cERtTzlZeks1VjA3U09QWlduYldpZkpBQTNtYTROOFl3VkZVY1l1d0VJZ3dxdmR1a2dYWmNZWVV1

N2R5ZTRXOGY2UGNzUlota1p2aTBua0t3U19yRW9CbXN1bXdZbFpTVWo5YV9ka3FFeTlMNGpqSkF5

Tkdha3VmLVMyaHRHQ1c3NGRVRzJEODd6dFlnYm8weENQUGZtUU5HeG9TVHNkZ2RKOHVpTU5DYmp1

Z0s0WHBISGxualNCdE10N25MUmEzUkp5R1VvTExYSlgtWEdTYnVBNlZqakh0d0o0VXdRNG1zdzl1

Rk5pVG81OE93RFRGR0Y4bVJtOTFHbDVWVW9ra214OTU4amQtWnd4M212RHFoaTBPSlUzbXBxa2M0

aW1DVlBIX2kyQkZ2cE94M0xfTkRNUkx1dW81bWd4c1dyNWxTSkUxZW1mVmdRcU5vUjFQWTFMWEFF

eDFuSWFRTGxMZzdxaU9INjNPQzVFVlQ4aWxSR1pPbnhoRi0tVnRUNlpqNExON01KQ2w1RWhFVTBf

VnlqMmp1N1JmRUtfcUw2ay1Kd1RDOTFyN1lzeGpWTEJkeDhDYmhMQ09mVHlLM3lBSGRwX2dtZVk3

SmhzczdVRTkwY2JsLUNfcm56TmNhR094MkUtV2lhVi1QWHR4TlBReGJZZmNHa3VpV1ozNW9uTWtQ

OWtwWE9teGJNV2R5UTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM2NjQy

NzI3PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9l

aHoxODk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGllc2E8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxS

ZWNOdW0+NDA3ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi

PjM4PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA3ODwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFzZXMy

cjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MjUxODU1Ij40MDc4PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DaGllc2EsIFMuIFQuPC9hdXRob3I+PGF1

dGhvcj5NYXNpLCBTLjwvYXV0aG9yPjxhdXRob3I+U2hpcGxleSwgTS4gSi48L2F1dGhvcj48YXV0

aG9yPkVsbGlucywgRS4gQS48L2F1dGhvcj48YXV0aG9yPkZyYXNlciwgQS4gRy48L2F1dGhvcj48

YXV0aG9yPkh1Z2hlcywgQS4gRC48L2F1dGhvcj48YXV0aG9yPlBhdGVsLCBSLiBTLjwvYXV0aG9y

PjxhdXRob3I+S2hpciwgQS4gVy48L2F1dGhvcj48YXV0aG9yPkhhbGNveCwgSi4gUC48L2F1dGhv

cj48YXV0aG9yPlNpbmdoLU1hbm91eCwgQS48L2F1dGhvcj48YXV0aG9yPktpdmltYWtpLCBNLjwv

YXV0aG9yPjxhdXRob3I+Q2VsZXJtYWplciwgRC4gUy48L2F1dGhvcj48YXV0aG9yPkRlYW5maWVs

ZCwgSi4gRS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5O

YXRpb25hbCBDZW50cmUgZm9yIENhcmRpb3Zhc2N1bGFyIFByZXZlbnRpb25zIGFuZCBPdXRjb21l

cywgVUNMIEluc3RpdHV0ZSBvZiBDYXJkaW92YXNjdWxhciBTY2llbmNlLCAxIFN0LiBNYXJ0aW4m

YXBvcztzIExlIEdyYW5kLCBMb25kb24sIFVLLiYjeEQ7RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBh

bmQgRXhwZXJpbWVudGFsIE1lZGljaW5lLCBVbml2ZXJzaXRhIGRpIFBpc2EsIEJ1aWxkaW5nIDgs

IFMuIENoaWFyYSBIb3NwaXRhbCwgVmlhIFJvbWEgNjcsIFBpc2EsIEl0YWx5LiYjeEQ7RGVwYXJ0

bWVudCBvZiBFcGlkZW1pb2xvZ3kgYW5kIFB1YmxpYyBIZWFsdGgsIFVDTCwgMS0xOSBUb3JyaW5n

dG9uIFBsYWNlLCBMb25kb24sIFVLLiYjeEQ7SW5zdGl0dXRlIG9mIExpZmUgU2NpZW5jZSwgU3dh

bnNlYSBVbml2ZXJzaXR5IE1lZGljYWwgU2Nob29sLCBTd2Fuc2VhIFVuaXZlcnNpdHksIFNpbmds

ZXRvbiBQYXJrLCBTd2Fuc2VhLCBVSy4mI3hEO1NjaG9vbCBvZiBNZWRpY2luZSwgSGVhdGggUGFy

aywgQ2FyZGlmZiwgVUsuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIFVuaXZlcnNpdHkg

SG9zcGl0YWwgb2YgV2FsZXMsIEhlYXRoIFBhcmssIENhcmRpZmYsIFVLLiYjeEQ7RGVwYXJ0bWVu

dCBvZiBQb3B1bGF0aW9uIFNjaWVuY2UgYW5kIEV4cGVyaW1lbnRhbCBNZWRpY2luZSwgVUNMIElu

c3RpdHV0ZSBvZiBDYXJkaW92YXNjdWxhciBTY2llbmNlLCA2OS03NSBDaGVuaWVzIE1ld3MsIExv

bmRvbiwgVUsuJiN4RDtNZWRpY2FsIFJlc2VhcmNoIENvdW5jaWwgVW5pdCBmb3IgTGlmZWxvbmcg

SGVhbHRoIGFuZCBBZ2VpbmcgYXQgVUNMLCAzMyBCZWRmb3JkIFBsYWNlLCBMb25kb24sIFVLLiYj

eEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBCYXJ0JmFwb3M7cyBIZWFydCBDZW50cmUsIFN0

IEJhcnRob2xvbWV3JmFwb3M7cyBIb3NwaXRhbCwgVyBTbWl0aGZpZWxkLCBMb25kb24sIFVLLiYj

eEQ7QmlvbWVkaWNhbCBFbmdpbmVlcmluZyBSZXNlYXJjaCBUaGVtZSwgQnJ1bmVsIFVuaXZlcnNp

dHkgTG9uZG9uLCBLaW5nc3RvbiBMYW5lLCBVeGJyaWRnZSwgVUsuJiN4RDtJbnNlcm0gVTExNTMs

IEVwaWRlbWlvbG9neSBvZiBBZ2VpbmcgYW5kIE5ldXJvZGVnZW5lcmF0aXZlIERpc2Vhc2VzLCBG

YWN1bHR5IG9mIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIFBhcmlzLCAxMCBBdmVudWUgZGUgVmVy

ZHVuLCBQYXJpcywgRnJhbmNlLiYjeEQ7SGVhcnQgUmVzZWFyY2ggSW5zdGl0dXRlLCBFbGl6YSBT

dHJlZXQsIE5ld3Rvd24sIE5TVywgQXVzdHJhbGlhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPkNhcm90aWQgYXJ0ZXJ5IHdhdmUgaW50ZW5zaXR5IGluIG1pZC0gdG8gbGF0ZS1saWZlIHBy

ZWRpY3RzIGNvZ25pdGl2ZSBkZWNsaW5lOiB0aGUgV2hpdGVoYWxsIElJIHN0dWR5PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBh

Z2VzPjIzMDAtMjMwOTwvcGFnZXM+PHZvbHVtZT40MDwvdm9sdW1lPjxudW1iZXI+Mjg8L251bWJl

cj48a2V5d29yZHM+PGtleXdvcmQ+Q2FyZGlvdmFzY3VsYXIgcmlzayBmYWN0b3JzPC9rZXl3b3Jk

PjxrZXl3b3JkPkNvZ25pdGl2ZSBkZWNsaW5lPC9rZXl3b3JkPjxrZXl3b3JkPldhdmUgaW50ZW5z

aXR5PC9rZXl3b3JkPjxrZXl3b3JkPldoaXRlaGFsbCBJSSBzdHVkeTwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsIDIxPC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5

NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDk1Nzg2MzwvYWNjZXNzaW9u

LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMzA5NTc4NjM8L3VybD48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3Yv

cG1jL2FydGljbGVzL1BNQzY2NDI3MjcvcGRmL2VoejE4OS5wZGY8L3VybD48dXJsPmh0dHBzOi8v

d2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9laHoxODkucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5

T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBbXd3Z2dKb0Jna3Foa2lHOXcw

QkJ3YWdnZ0paTUlJQ1ZRSUJBRENDQWs0R0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3

RVFRTWRWdk15c3NoUXF3XzJsZVJBZ0VRZ0lJQ0g0aFlCa1d6WUxiU1hTX0dfdWFOUV95STRaa0Nx

YXVsc0tDQTFPMmt2Zko0Zy1nY2FaalZwRG8zcDR5bnpud0FGU2lncHZsdXBWdlQ3VE1MWXAxOE03

dVdxSjBkcHI4VEdfcGpycmMyMTIxNV92Ym55MVZ5Qkl0NFMwb09mR3AwZEl0QlFHcWNhSkdRZDc3

OXc0WUo2cGlvZUdkQXpFdk41UHhDb2N3UWtCMWVzNjIyUlFDSEp3RVFnZ2k1NWUwMC1JNEhvZ3dX

cERtTzlZeks1VjA3U09QWlduYldpZkpBQTNtYTROOFl3VkZVY1l1d0VJZ3dxdmR1a2dYWmNZWVV1

N2R5ZTRXOGY2UGNzUlota1p2aTBua0t3U19yRW9CbXN1bXdZbFpTVWo5YV9ka3FFeTlMNGpqSkF5

Tkdha3VmLVMyaHRHQ1c3NGRVRzJEODd6dFlnYm8weENQUGZtUU5HeG9TVHNkZ2RKOHVpTU5DYmp1

Z0s0WHBISGxualNCdE10N25MUmEzUkp5R1VvTExYSlgtWEdTYnVBNlZqakh0d0o0VXdRNG1zdzl1

Rk5pVG81OE93RFRGR0Y4bVJtOTFHbDVWVW9ra214OTU4amQtWnd4M212RHFoaTBPSlUzbXBxa2M0

aW1DVlBIX2kyQkZ2cE94M0xfTkRNUkx1dW81bWd4c1dyNWxTSkUxZW1mVmdRcU5vUjFQWTFMWEFF

eDFuSWFRTGxMZzdxaU9INjNPQzVFVlQ4aWxSR1pPbnhoRi0tVnRUNlpqNExON01KQ2w1RWhFVTBf

VnlqMmp1N1JmRUtfcUw2ay1Kd1RDOTFyN1lzeGpWTEJkeDhDYmhMQ09mVHlLM3lBSGRwX2dtZVk3

SmhzczdVRTkwY2JsLUNfcm56TmNhR094MkUtV2lhVi1QWHR4TlBReGJZZmNHa3VpV1ozNW9uTWtQ

OWtwWE9teGJNV2R5UTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM2NjQy

NzI3PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9l

aHoxODk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

AG==

ADDIN EN.CITE.DATA 38, peak forward-travelling compression wave intensity (FCWI) was assessed using Duplex ultrasound within the common carotid arteries in 3,191 individuals [mean age = 61 years; 75% male] and serial measures of cognitive function were taken at baseline and almost 10 years later. Higher FCWI at baseline was associated with accelerated cognitive decline during follow-up and this association was largely driven by cognitive changes in individuals with the highest FCWI. Compared to other participants, this group was approximately 50% more likely to exhibit cognitive decline, even after adjustments for multiple potential confounding factors. Patients with high stroke risk and atrial fibrillation who are unsuitable to oral anticoagulants (OACs) require other stroke prevention strategies. The multicenter, non-randomized, first-in-human clinical Carotid Artery Implant for Trapping Upstream Emboli for Preventing Stroke in Atrial Fibrillation Patients (CAPTURE) trial sought to determine the feasibility and safety of a novel permanent coil filter directly placed into both common carotid arteries designed to capture emboli >1.4 mm in diameter.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWRkeTwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MDc5PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

Mzk8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDc5PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkyNTIwMTEiPjQwNzk8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJlZGR5LCBWLiBZLjwvYXV0aG9yPjxhdXRo

b3I+TmV1emlsLCBQLjwvYXV0aG9yPjxhdXRob3I+ZGUgUG90dGVyLCBULjwvYXV0aG9yPjxhdXRo

b3I+dmFuIGRlciBIZXlkZW4sIEouPC9hdXRob3I+PGF1dGhvcj5Ucm9tcCwgUy4gQy48L2F1dGhv

cj48YXV0aG9yPlJlbnNpbmcsIEIuPC9hdXRob3I+PGF1dGhvcj5KaXJlc292YSwgRS48L2F1dGhv

cj48YXV0aG9yPkR1amthLCBMLjwvYXV0aG9yPjxhdXRob3I+TGVrZXNvdmEsIFYuPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJk

aW9sb2d5LCBIb21vbGthIEhvc3BpdGFsLCBQcmFndWUsIEN6ZWNoIFJlcHVibGljOyBEZXBhcnRt

ZW50IG9mIENhcmRpb2xvZ3ksIEljYWhuIFNjaG9vbCBvZiBNZWRpY2luZSBhdCBNb3VudCBTaW5h

aSwgTmV3IFlvcmssIE5ldyBZb3JrLiBFbGVjdHJvbmljIGFkZHJlc3M6IHZpdmVrLnJlZGR5QG1v

dW50c2luYWkub3JnLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBIb21vbGthIEhvc3Bp

dGFsLCBQcmFndWUsIEN6ZWNoIFJlcHVibGljLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5

LCBPTFYgWmlla2VuaHVpcywgQWFsc3QsIEJlbGdpdW0uJiN4RDtEZXBhcnRtZW50IG9mIENhcmRp

b2xvZ3ksIFNpbnQtQW50b25pdXMgWmlla2VuaHVpcywgTmlldXdlZ2VpbiwgdGhlIE5ldGhlcmxh

bmRzLiYjeEQ7RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBOZXVyb3BoeXNpb2xvZ3ksIFNpbnQtQW50

b25pdXMgWmlla2VuaHVpcywgTmlldXdlZ2VpbiwgdGhlIE5ldGhlcmxhbmRzLjwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPlBlcm1hbmVudCBQZXJjdXRhbmVvdXMgQ2Fyb3RpZCBBcnRlcnkg

RmlsdGVyIHRvIFByZXZlbnQgU3Ryb2tlIGluIEF0cmlhbCBGaWJyaWxsYXRpb24gUGF0aWVudHM6

IFRoZSBDQVBUVVJFIFRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQW0gQ29sbCBDYXJk

aW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjgyOS04Mzk8L3BhZ2VzPjx2b2x1

bWU+NzQ8L3ZvbHVtZT48bnVtYmVyPjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+YXRyaWFs

IGZpYnJpbGxhdGlvbjwva2V5d29yZD48a2V5d29yZD5jYXJvdGlkIGZpbHRlcjwva2V5d29yZD48

a2V5d29yZD5jb21tb24gY2Fyb3RpZCBhcnRlcnk8L2tleXdvcmQ+PGtleXdvcmQ+ZW1ib2xpYyBw

cm90ZWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPm9yYWwgYW50aWNvYWd1bGF0aW9uPC9rZXl3b3Jk

PjxrZXl3b3JkPnN0cm9rZSBwcmV2ZW50aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5

ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWcgMjA8L2RhdGU+PC9wdWItZGF0ZXM+

PC9kYXRlcz48aXNibj4xNTU4LTM1OTcgKEVsZWN0cm9uaWMpJiN4RDswNzM1LTEwOTcgKExpbmtp

bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMxMDg1MzIwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMTA4

NTMyMDwvdXJsPjx1cmw+aHR0cHM6Ly9wZGYuc2NpZW5jZWRpcmVjdGFzc2V0cy5jb20vMjcxMDI3

LzEtczIuMC1TMDczNTEwOTcxOFgwMDM4Mi8xLXMyLjAtUzA3MzUxMDk3MTkzNTAwNjUvbWFpbi5w

ZGY/WC1BbXotU2VjdXJpdHktVG9rZW49QWdvSmIzSnBaMmx1WDJWakVEOGFDWFZ6TFdWaGMzUXRN

U0pJTUVZQ0lRQ3pneUk0YUxGdVhsNGI1bUgyOSUyQm9jdjd4UFBtbnZLTmp6Nk1zNnBtdFQzZ0lo

QU1uRkolMkZDcUFWdEt0bUUlMkZpejhQdUVNOCUyRnNZdU5sUWlkZVFNSHRxcnJ5bnBLdG9EQ0Jn

UUFob01NRFU1TURBek5UUTJPRFkxSWd3Y1ElMkZYaUxTUENsSWo2Rng0cXR3UFlZQW5RVE5iYWxl

b01LZ2NUQmt5MmJtUzNlJTJCMnlWUUNvSk1wQlRXWXNuWlk0ajcyYjlMRTRJdWZramVNSExRM0Rs

a3Jrc2hGMUVBZkMxbEphc041TVNpN3N0bDhnaVFZRW9oY3BoaGEzd0ZzcDVoSjBBMFdoeEQ3OTd5

M3RWcTNKTzIlMkZlWUpLb1BLR3VGRG1vbFB5Rk5NVUxGazVQUXc3QVpHYWl1dEZpbnNralk5RmQ1

aWVobGVjWGdrc1klMkYyWTN5MGlIbTJ3NzZsQkF3dEtBTGtQR0h3R2JVc3V1UFhuZlFxUHQlMkZq

dm15NzNJbmt3SlFOJTJCSGhCU2pFdlp2eUJzZkJzc0FyVmVYcTZFZk10bzNybFhkamdGR003VHhT

bXJiTXFQM0haT0RVdTZGeXEzOGtxTTNHMGhUcGpVUmklMkJ2aE92RGk0VUN4d3BpZXppUG1iZlBv

ZU40dTRPMVJsM1RHbnhEb01LdWFzSDFlcDBoQUtaTXlXd0VidWwyckUlMkJLQSUyQmJGMzN5UyUy

RmtnZG83RWduTFVsclNVR2JmJTJGcjNCWEc3elBRWmlJcG10R3VpZ3FJZnRwRXZNUlhyU1RKZkFj

c0REWW1aQUdyakNUNzN2bE9hJTJCMkRyZlFBZjJuVVFQZmdYMUhKS1pTdzZFc084VDZJV1l6S2Ja

cEdaUkRmeWpPTDRZc3Y0cUdhUVJhSWs2TEtCTnJFMUZtbHR0YkEwMm1CTFdPMGt4T1BhRzZQck9a

b3NJVWsxb25Eek5lQnVocERCM0FMJTJGakZZNk1OZXVvJTJCd0ZPck1CblFkQXNsU0JSTnNBWERj

Q1JFTnBvVjNBMXRBT1BNMkNsdFlld3pKaGVXaE51SmxDQmFLeklwWWdQT0dOZ1FXTGdlZDI4aDZy

d2hvWlRIM2xqVzNPJTJCbk1peUp3RnNjRkFhU05ZQzM1aTFtS2JCOG0wJTJCUWRKNlklMkJxUmQ0

bmR3TWFoQnRoY0I5Q2t2a2d2V0NJWFZEa1k1cEFMb1VEUWwyb2x0a0t6VnBIVm1qRjc4UWxSdlZn

MDdzdXglMkIwWHN3S3d5ZERNSzBtUVdMY1RzTGtXNCUyQnJNdVgxdmJYNmdXV0dVRmxhMVNqVnNP

SzU3VjV3JTNEJmFtcDtYLUFtei1BbGdvcml0aG09QVdTNC1ITUFDLVNIQTI1NiZhbXA7WC1BbXot

RGF0ZT0yMDE5MDkyM1QxNTIwMzVaJmFtcDtYLUFtei1TaWduZWRIZWFkZXJzPWhvc3QmYW1wO1gt

QW16LUV4cGlyZXM9MzAwJmFtcDtYLUFtei1DcmVkZW50aWFsPUFTSUFRM1BIQ1ZUWVlZWko0NFlV

JTJGMjAxOTA5MjMlMkZ1cy1lYXN0LTElMkZzMyUyRmF3czRfcmVxdWVzdCZhbXA7WC1BbXotU2ln

bmF0dXJlPWZmYzkxOGU2MjZmOWM1MTllZjMzNmY4YzcxZmQ1OTE2MTU4ZGUzOGU1MThkMjU5NWE3

NGY3YTRjNDBjYjQ2MWUmYW1wO2hhc2g9Zjg5YzdjMzQzYzMwYjg1NjllNGExOTk5YWZiZGJjMjll

OTMzMzJmMjk3ZDU5MmI1MzQwZGFmYmM1NzBiNGYxNSZhbXA7aG9zdD02ODA0MmM5NDM1OTEwMTNh

YzJiMjQzMGE4OWIyNzBmNmFmMmM3NmQ4ZGZkMDg2YTA3MTc2YWZlN2M3NmMyYzYxJmFtcDtwaWk9

UzA3MzUxMDk3MTkzNTAwNjUmYW1wO3RpZD1zcGRmLWE5YTNmMWQwLTgyMzYtNDcwNC1iYzc1LTg0

MzQ3OWMxYzkzNiZhbXA7c2lkPWI0MTNkMDA0M2IxNjAxNDdkYTViM2E0Mjc0ZTM2YzBkOWRkNmd4

cnFiJmFtcDt0eXBlPWNsaWVudDwvdXJsPjx1cmw+aHR0cHM6Ly93d3cuc2NpZW5jZWRpcmVjdC5j

b20vc2NpZW5jZS9hcnRpY2xlL3BpaS9TMDczNTEwOTcxOTM1MDA2NT92aWElM0RpaHViPC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ou

amFjYy4yMDE5LjA0LjAzNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWRkeTwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MDc5PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

Mzk8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDc5PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkyNTIwMTEiPjQwNzk8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJlZGR5LCBWLiBZLjwvYXV0aG9yPjxhdXRo

b3I+TmV1emlsLCBQLjwvYXV0aG9yPjxhdXRob3I+ZGUgUG90dGVyLCBULjwvYXV0aG9yPjxhdXRo

b3I+dmFuIGRlciBIZXlkZW4sIEouPC9hdXRob3I+PGF1dGhvcj5Ucm9tcCwgUy4gQy48L2F1dGhv

cj48YXV0aG9yPlJlbnNpbmcsIEIuPC9hdXRob3I+PGF1dGhvcj5KaXJlc292YSwgRS48L2F1dGhv

cj48YXV0aG9yPkR1amthLCBMLjwvYXV0aG9yPjxhdXRob3I+TGVrZXNvdmEsIFYuPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJk

aW9sb2d5LCBIb21vbGthIEhvc3BpdGFsLCBQcmFndWUsIEN6ZWNoIFJlcHVibGljOyBEZXBhcnRt

ZW50IG9mIENhcmRpb2xvZ3ksIEljYWhuIFNjaG9vbCBvZiBNZWRpY2luZSBhdCBNb3VudCBTaW5h

aSwgTmV3IFlvcmssIE5ldyBZb3JrLiBFbGVjdHJvbmljIGFkZHJlc3M6IHZpdmVrLnJlZGR5QG1v

dW50c2luYWkub3JnLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBIb21vbGthIEhvc3Bp

dGFsLCBQcmFndWUsIEN6ZWNoIFJlcHVibGljLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5

LCBPTFYgWmlla2VuaHVpcywgQWFsc3QsIEJlbGdpdW0uJiN4RDtEZXBhcnRtZW50IG9mIENhcmRp

b2xvZ3ksIFNpbnQtQW50b25pdXMgWmlla2VuaHVpcywgTmlldXdlZ2VpbiwgdGhlIE5ldGhlcmxh

bmRzLiYjeEQ7RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBOZXVyb3BoeXNpb2xvZ3ksIFNpbnQtQW50

b25pdXMgWmlla2VuaHVpcywgTmlldXdlZ2VpbiwgdGhlIE5ldGhlcmxhbmRzLjwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPlBlcm1hbmVudCBQZXJjdXRhbmVvdXMgQ2Fyb3RpZCBBcnRlcnkg

RmlsdGVyIHRvIFByZXZlbnQgU3Ryb2tlIGluIEF0cmlhbCBGaWJyaWxsYXRpb24gUGF0aWVudHM6

IFRoZSBDQVBUVVJFIFRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQW0gQ29sbCBDYXJk

aW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjgyOS04Mzk8L3BhZ2VzPjx2b2x1

bWU+NzQ8L3ZvbHVtZT48bnVtYmVyPjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+YXRyaWFs

IGZpYnJpbGxhdGlvbjwva2V5d29yZD48a2V5d29yZD5jYXJvdGlkIGZpbHRlcjwva2V5d29yZD48

a2V5d29yZD5jb21tb24gY2Fyb3RpZCBhcnRlcnk8L2tleXdvcmQ+PGtleXdvcmQ+ZW1ib2xpYyBw

cm90ZWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPm9yYWwgYW50aWNvYWd1bGF0aW9uPC9rZXl3b3Jk

PjxrZXl3b3JkPnN0cm9rZSBwcmV2ZW50aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5

ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWcgMjA8L2RhdGU+PC9wdWItZGF0ZXM+

PC9kYXRlcz48aXNibj4xNTU4LTM1OTcgKEVsZWN0cm9uaWMpJiN4RDswNzM1LTEwOTcgKExpbmtp

bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMxMDg1MzIwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMTA4

NTMyMDwvdXJsPjx1cmw+aHR0cHM6Ly9wZGYuc2NpZW5jZWRpcmVjdGFzc2V0cy5jb20vMjcxMDI3

LzEtczIuMC1TMDczNTEwOTcxOFgwMDM4Mi8xLXMyLjAtUzA3MzUxMDk3MTkzNTAwNjUvbWFpbi5w

ZGY/WC1BbXotU2VjdXJpdHktVG9rZW49QWdvSmIzSnBaMmx1WDJWakVEOGFDWFZ6TFdWaGMzUXRN

U0pJTUVZQ0lRQ3pneUk0YUxGdVhsNGI1bUgyOSUyQm9jdjd4UFBtbnZLTmp6Nk1zNnBtdFQzZ0lo

QU1uRkolMkZDcUFWdEt0bUUlMkZpejhQdUVNOCUyRnNZdU5sUWlkZVFNSHRxcnJ5bnBLdG9EQ0Jn

UUFob01NRFU1TURBek5UUTJPRFkxSWd3Y1ElMkZYaUxTUENsSWo2Rng0cXR3UFlZQW5RVE5iYWxl

b01LZ2NUQmt5MmJtUzNlJTJCMnlWUUNvSk1wQlRXWXNuWlk0ajcyYjlMRTRJdWZramVNSExRM0Rs

a3Jrc2hGMUVBZkMxbEphc041TVNpN3N0bDhnaVFZRW9oY3BoaGEzd0ZzcDVoSjBBMFdoeEQ3OTd5

M3RWcTNKTzIlMkZlWUpLb1BLR3VGRG1vbFB5Rk5NVUxGazVQUXc3QVpHYWl1dEZpbnNralk5RmQ1

aWVobGVjWGdrc1klMkYyWTN5MGlIbTJ3NzZsQkF3dEtBTGtQR0h3R2JVc3V1UFhuZlFxUHQlMkZq

dm15NzNJbmt3SlFOJTJCSGhCU2pFdlp2eUJzZkJzc0FyVmVYcTZFZk10bzNybFhkamdGR003VHhT

bXJiTXFQM0haT0RVdTZGeXEzOGtxTTNHMGhUcGpVUmklMkJ2aE92RGk0VUN4d3BpZXppUG1iZlBv

ZU40dTRPMVJsM1RHbnhEb01LdWFzSDFlcDBoQUtaTXlXd0VidWwyckUlMkJLQSUyQmJGMzN5UyUy

RmtnZG83RWduTFVsclNVR2JmJTJGcjNCWEc3elBRWmlJcG10R3VpZ3FJZnRwRXZNUlhyU1RKZkFj

c0REWW1aQUdyakNUNzN2bE9hJTJCMkRyZlFBZjJuVVFQZmdYMUhKS1pTdzZFc084VDZJV1l6S2Ja

cEdaUkRmeWpPTDRZc3Y0cUdhUVJhSWs2TEtCTnJFMUZtbHR0YkEwMm1CTFdPMGt4T1BhRzZQck9a

b3NJVWsxb25Eek5lQnVocERCM0FMJTJGakZZNk1OZXVvJTJCd0ZPck1CblFkQXNsU0JSTnNBWERj

Q1JFTnBvVjNBMXRBT1BNMkNsdFlld3pKaGVXaE51SmxDQmFLeklwWWdQT0dOZ1FXTGdlZDI4aDZy

d2hvWlRIM2xqVzNPJTJCbk1peUp3RnNjRkFhU05ZQzM1aTFtS2JCOG0wJTJCUWRKNlklMkJxUmQ0

bmR3TWFoQnRoY0I5Q2t2a2d2V0NJWFZEa1k1cEFMb1VEUWwyb2x0a0t6VnBIVm1qRjc4UWxSdlZn

MDdzdXglMkIwWHN3S3d5ZERNSzBtUVdMY1RzTGtXNCUyQnJNdVgxdmJYNmdXV0dVRmxhMVNqVnNP

SzU3VjV3JTNEJmFtcDtYLUFtei1BbGdvcml0aG09QVdTNC1ITUFDLVNIQTI1NiZhbXA7WC1BbXot

RGF0ZT0yMDE5MDkyM1QxNTIwMzVaJmFtcDtYLUFtei1TaWduZWRIZWFkZXJzPWhvc3QmYW1wO1gt

QW16LUV4cGlyZXM9MzAwJmFtcDtYLUFtei1DcmVkZW50aWFsPUFTSUFRM1BIQ1ZUWVlZWko0NFlV

JTJGMjAxOTA5MjMlMkZ1cy1lYXN0LTElMkZzMyUyRmF3czRfcmVxdWVzdCZhbXA7WC1BbXotU2ln

bmF0dXJlPWZmYzkxOGU2MjZmOWM1MTllZjMzNmY4YzcxZmQ1OTE2MTU4ZGUzOGU1MThkMjU5NWE3

NGY3YTRjNDBjYjQ2MWUmYW1wO2hhc2g9Zjg5YzdjMzQzYzMwYjg1NjllNGExOTk5YWZiZGJjMjll

OTMzMzJmMjk3ZDU5MmI1MzQwZGFmYmM1NzBiNGYxNSZhbXA7aG9zdD02ODA0MmM5NDM1OTEwMTNh

YzJiMjQzMGE4OWIyNzBmNmFmMmM3NmQ4ZGZkMDg2YTA3MTc2YWZlN2M3NmMyYzYxJmFtcDtwaWk9

UzA3MzUxMDk3MTkzNTAwNjUmYW1wO3RpZD1zcGRmLWE5YTNmMWQwLTgyMzYtNDcwNC1iYzc1LTg0

MzQ3OWMxYzkzNiZhbXA7c2lkPWI0MTNkMDA0M2IxNjAxNDdkYTViM2E0Mjc0ZTM2YzBkOWRkNmd4

cnFiJmFtcDt0eXBlPWNsaWVudDwvdXJsPjx1cmw+aHR0cHM6Ly93d3cuc2NpZW5jZWRpcmVjdC5j

b20vc2NpZW5jZS9hcnRpY2xlL3BpaS9TMDczNTEwOTcxOTM1MDA2NT92aWElM0RpaHViPC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ou

amFjYy4yMDE5LjA0LjAzNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA 39 Patients received aspirin/clopidogrel for 3 months, and aspirin thereafter. In 3 centres, 25 patients with atrial fibrillation, with CHA2DS2-VASc ≥2, who were unsuitable for OACs and had no carotid stenosis >30% were enrolled. The procedure success was 92%; 1 patient had unilateral deployment. There were no device/procedure-related major adverse events. After 6-month mean follow-up, asymptomatic thrombi were detected in 4 patients (1 bilateral, 4 unilateral) and the thrombi dissolved with subcutaneous heparin. Permanent carotid filter placement for stroke prophylaxis seems technically feasible and safe. Larger studies and a comparison with the use of left atrial appendage occluders are necessary.Venous thromboembolism (VTE)In 2019, the ESC issued updated guidelines for management of patients with acute pulmonary embolism (PE).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb25zdGFudGluaWRlczwvQXV0aG9yPjxZZWFyPjIwMTk8

L1llYXI+PFJlY051bT40MDkzPC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBl

cnNjcmlwdCI+NDA8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDkz

PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZq

eHB6YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5MzU5NzMiPjQwOTM8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktvbnN0YW50aW5pZGVzLCBT

LiBWLjwvYXV0aG9yPjxhdXRob3I+TWV5ZXIsIEcuPC9hdXRob3I+PGF1dGhvcj5CZWNhdHRpbmks

IEMuPC9hdXRob3I+PGF1dGhvcj5CdWVubywgSC48L2F1dGhvcj48YXV0aG9yPkdlZXJzaW5nLCBH

LiBKLjwvYXV0aG9yPjxhdXRob3I+SGFyam9sYSwgVi4gUC48L2F1dGhvcj48YXV0aG9yPkh1aXNt

YW4sIE0uIFYuPC9hdXRob3I+PGF1dGhvcj5IdW1iZXJ0LCBNLjwvYXV0aG9yPjxhdXRob3I+SmVu

bmluZ3MsIEMuIFMuPC9hdXRob3I+PGF1dGhvcj5KaW1lbmV6LCBELjwvYXV0aG9yPjxhdXRob3I+

S3VjaGVyLCBOLjwvYXV0aG9yPjxhdXRob3I+TGFuZywgSS4gTS48L2F1dGhvcj48YXV0aG9yPkxh

bmtlaXQsIE0uPC9hdXRob3I+PGF1dGhvcj5Mb3J1c3NvLCBSLjwvYXV0aG9yPjxhdXRob3I+TWF6

em9sYWksIEwuPC9hdXRob3I+PGF1dGhvcj5NZW5ldmVhdSwgTi48L2F1dGhvcj48YXV0aG9yPk5p

IEFpbmxlLCBGLjwvYXV0aG9yPjxhdXRob3I+UHJhbmRvbmksIFAuPC9hdXRob3I+PGF1dGhvcj5Q

cnVzemN6eWssIFAuPC9hdXRob3I+PGF1dGhvcj5SaWdoaW5pLCBNLjwvYXV0aG9yPjxhdXRob3I+

VG9yYmlja2ksIEEuPC9hdXRob3I+PGF1dGhvcj5WYW4gQmVsbGUsIEUuPC9hdXRob3I+PGF1dGhv

cj5aYW1vcmFubywgSi4gTC48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIFNjaWVudGlmaWMgRG9j

dW1lbnQgR3JvdXA8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0

bGU+MjAxOSBFU0MgR3VpZGVsaW5lcyBmb3IgdGhlIGRpYWdub3NpcyBhbmQgbWFuYWdlbWVudCBv

ZiBhY3V0ZSBwdWxtb25hcnkgZW1ib2xpc20gZGV2ZWxvcGVkIGluIGNvbGxhYm9yYXRpb24gd2l0

aCB0aGUgRXVyb3BlYW4gUmVzcGlyYXRvcnkgU29jaWV0eSAoRVJTKTwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxrZXl3b3Jkcz48

a2V5d29yZD5HdWlkZWxpbmVzPC9rZXl3b3JkPjxrZXl3b3JkPmFudGljb2FndWxhdGlvbjwva2V5

d29yZD48a2V5d29yZD5iaW9tYXJrZXJzPC9rZXl3b3JkPjxrZXl3b3JkPmRpYWdub3Npczwva2V5

d29yZD48a2V5d29yZD5keXNwbm9lYTwva2V5d29yZD48a2V5d29yZD5lY2hvY2FyZGlvZ3JhcGh5

PC9rZXl3b3JkPjxrZXl3b3JkPmVtYm9sZWN0b215PC9rZXl3b3JkPjxrZXl3b3JkPmhlYXJ0IGZh

aWx1cmU8L2tleXdvcmQ+PGtleXdvcmQ+cHJlZ25hbmN5PC9rZXl3b3JkPjxrZXl3b3JkPnB1bG1v

bmFyeSBlbWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5yaWdodCB2ZW50cmljbGU8L2tleXdvcmQ+

PGtleXdvcmQ+cmlzayBhc3Nlc3NtZW50PC9rZXl3b3JkPjxrZXl3b3JkPnNob2NrPC9rZXl3b3Jk

PjxrZXl3b3JkPnRocm9tYm9seXNpczwva2V5d29yZD48a2V5d29yZD50cmVhdG1lbnQ8L2tleXdv

cmQ+PGtleXdvcmQ+dmVub3VzIHRocm9tYm9lbWJvbGlzbTwva2V5d29yZD48a2V5d29yZD52ZW5v

dXMgdGhyb21ib3Npczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+QXVnIDMxPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNj

ZXNzaW9uLW51bT4zMTUwNDQyOTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1

cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzE1MDQ0Mjk8L3VybD48dXJs

Pmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9laHo0MDUucGRmP3Rva2VuPUFRRUNB

SGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBcFl3Z2dLU0Jn

a3Foa2lHOXcwQkJ3YWdnZ0tETUlJQ2Z3SUJBRENDQW5nR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtn

QlpRTUVBUzR3RVFRTUVRanRfQUoxTkNxSzlWdk1BZ0VRZ0lJQ1NmOXE4YlQ2bENJc1BRTHlfTXU1

bTNhR2RlQjJBd0FNakFGS3VuajFUZm9CVWc5dmEwM1pab0RlREFYYWVaZ1JNbnpac2JGcUlZbHpm

a2x0UWdieUQ2YU12Q1dtMWRoTGVtSEVqRnZjNVNqY09qUGZjeTZocExyTzNGaE5XYUtXMF9mWGdD

djlWRWJ5MDByWDM3Q3VPME4tMmU0RDY2al9VRVBxQ25NMGI5eVFCOHV3ZkIxenhtaWdPX2RSLUxD

em1mbTcyWjVocjkteXY3RzR0SHExMFdBME04dWgzdnE4WnBSSV9aNXpPRHl5eWdxU1BCSXk2TTBP

LXRRQ2JMRmlTWXU5WWQ3SHhENkhVY0ZfZklvU0NPd3EwSGZFRlVRUW1yNlBkX3lLeE5qVThjbkFo

blN2Rjc2WVRfYnE2aXhyRzFDZWhwc2JSNndjVmhjZnRGUW03VHpWZkRrbEkydG9VTnFDUkViYVRk

WlkwUDI4LTlSblJENjhES044aUNodEdpQmowdFpjdUttazdUc0tZenVrZVh2YzRmamRoMm5nVTQw

NlpHbWRfQ2Y4MkhuNWRxV1pYMF9INDlGalZZcVJFYzlFUkVaOXFuYzdzdG9JYzZGejZvd0hGNHlE

eHJQYUxUZXlMYU82bk9wV3BUeTNjdzF1NkgxdkNBRG5mWWEwN0t1WnZwREhTR2tkZnc0bHQzd3pu

XzUtSmg4REw5X3BPRjVWSjJJZEpuMk9Za3A4c2Z0Tms1Q3BpSGJYMTByYkM2S2Vta1NuQWtibnZ1

Y0VsWEstQUdPTG80RTMxOVNJejVGZzdtRmlqTWpHaHdaRFVKc1JRYTB3aEpCRjVldkFVeU14NHRk

UjJ0eUZMVm05aWZBQ2xvb1VZU20xbGMycURidzVGck9nRURRV0xHcjdlQ1VNOHNsNHAyaTA2M05Q

akxwTXZHOER3clIxbW9sVFZXVkk3d0dJMU9Da2JaWVF2RTV1UkNWUVloa0pXaWV6aEZsb0k2WWlk

OUZNcW0tZ1JRQTBxZTNCZS10cjV3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHo0MDU8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb25zdGFudGluaWRlczwvQXV0aG9yPjxZZWFyPjIwMTk8

L1llYXI+PFJlY051bT40MDkzPC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBl

cnNjcmlwdCI+NDA8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDkz

PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZq

eHB6YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5MzU5NzMiPjQwOTM8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktvbnN0YW50aW5pZGVzLCBT

LiBWLjwvYXV0aG9yPjxhdXRob3I+TWV5ZXIsIEcuPC9hdXRob3I+PGF1dGhvcj5CZWNhdHRpbmks

IEMuPC9hdXRob3I+PGF1dGhvcj5CdWVubywgSC48L2F1dGhvcj48YXV0aG9yPkdlZXJzaW5nLCBH

LiBKLjwvYXV0aG9yPjxhdXRob3I+SGFyam9sYSwgVi4gUC48L2F1dGhvcj48YXV0aG9yPkh1aXNt

YW4sIE0uIFYuPC9hdXRob3I+PGF1dGhvcj5IdW1iZXJ0LCBNLjwvYXV0aG9yPjxhdXRob3I+SmVu

bmluZ3MsIEMuIFMuPC9hdXRob3I+PGF1dGhvcj5KaW1lbmV6LCBELjwvYXV0aG9yPjxhdXRob3I+

S3VjaGVyLCBOLjwvYXV0aG9yPjxhdXRob3I+TGFuZywgSS4gTS48L2F1dGhvcj48YXV0aG9yPkxh

bmtlaXQsIE0uPC9hdXRob3I+PGF1dGhvcj5Mb3J1c3NvLCBSLjwvYXV0aG9yPjxhdXRob3I+TWF6

em9sYWksIEwuPC9hdXRob3I+PGF1dGhvcj5NZW5ldmVhdSwgTi48L2F1dGhvcj48YXV0aG9yPk5p

IEFpbmxlLCBGLjwvYXV0aG9yPjxhdXRob3I+UHJhbmRvbmksIFAuPC9hdXRob3I+PGF1dGhvcj5Q

cnVzemN6eWssIFAuPC9hdXRob3I+PGF1dGhvcj5SaWdoaW5pLCBNLjwvYXV0aG9yPjxhdXRob3I+

VG9yYmlja2ksIEEuPC9hdXRob3I+PGF1dGhvcj5WYW4gQmVsbGUsIEUuPC9hdXRob3I+PGF1dGhv

cj5aYW1vcmFubywgSi4gTC48L2F1dGhvcj48YXV0aG9yPkUuIFMuIEMuIFNjaWVudGlmaWMgRG9j

dW1lbnQgR3JvdXA8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0

bGU+MjAxOSBFU0MgR3VpZGVsaW5lcyBmb3IgdGhlIGRpYWdub3NpcyBhbmQgbWFuYWdlbWVudCBv

ZiBhY3V0ZSBwdWxtb25hcnkgZW1ib2xpc20gZGV2ZWxvcGVkIGluIGNvbGxhYm9yYXRpb24gd2l0

aCB0aGUgRXVyb3BlYW4gUmVzcGlyYXRvcnkgU29jaWV0eSAoRVJTKTwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxrZXl3b3Jkcz48

a2V5d29yZD5HdWlkZWxpbmVzPC9rZXl3b3JkPjxrZXl3b3JkPmFudGljb2FndWxhdGlvbjwva2V5

d29yZD48a2V5d29yZD5iaW9tYXJrZXJzPC9rZXl3b3JkPjxrZXl3b3JkPmRpYWdub3Npczwva2V5

d29yZD48a2V5d29yZD5keXNwbm9lYTwva2V5d29yZD48a2V5d29yZD5lY2hvY2FyZGlvZ3JhcGh5

PC9rZXl3b3JkPjxrZXl3b3JkPmVtYm9sZWN0b215PC9rZXl3b3JkPjxrZXl3b3JkPmhlYXJ0IGZh

aWx1cmU8L2tleXdvcmQ+PGtleXdvcmQ+cHJlZ25hbmN5PC9rZXl3b3JkPjxrZXl3b3JkPnB1bG1v

bmFyeSBlbWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5yaWdodCB2ZW50cmljbGU8L2tleXdvcmQ+

PGtleXdvcmQ+cmlzayBhc3Nlc3NtZW50PC9rZXl3b3JkPjxrZXl3b3JkPnNob2NrPC9rZXl3b3Jk

PjxrZXl3b3JkPnRocm9tYm9seXNpczwva2V5d29yZD48a2V5d29yZD50cmVhdG1lbnQ8L2tleXdv

cmQ+PGtleXdvcmQ+dmVub3VzIHRocm9tYm9lbWJvbGlzbTwva2V5d29yZD48a2V5d29yZD52ZW5v

dXMgdGhyb21ib3Npczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+QXVnIDMxPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNj

ZXNzaW9uLW51bT4zMTUwNDQyOTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1

cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzE1MDQ0Mjk8L3VybD48dXJs

Pmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9laHo0MDUucGRmP3Rva2VuPUFRRUNB

SGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBcFl3Z2dLU0Jn

a3Foa2lHOXcwQkJ3YWdnZ0tETUlJQ2Z3SUJBRENDQW5nR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtn

QlpRTUVBUzR3RVFRTUVRanRfQUoxTkNxSzlWdk1BZ0VRZ0lJQ1NmOXE4YlQ2bENJc1BRTHlfTXU1

bTNhR2RlQjJBd0FNakFGS3VuajFUZm9CVWc5dmEwM1pab0RlREFYYWVaZ1JNbnpac2JGcUlZbHpm

a2x0UWdieUQ2YU12Q1dtMWRoTGVtSEVqRnZjNVNqY09qUGZjeTZocExyTzNGaE5XYUtXMF9mWGdD

djlWRWJ5MDByWDM3Q3VPME4tMmU0RDY2al9VRVBxQ25NMGI5eVFCOHV3ZkIxenhtaWdPX2RSLUxD

em1mbTcyWjVocjkteXY3RzR0SHExMFdBME04dWgzdnE4WnBSSV9aNXpPRHl5eWdxU1BCSXk2TTBP

LXRRQ2JMRmlTWXU5WWQ3SHhENkhVY0ZfZklvU0NPd3EwSGZFRlVRUW1yNlBkX3lLeE5qVThjbkFo

blN2Rjc2WVRfYnE2aXhyRzFDZWhwc2JSNndjVmhjZnRGUW03VHpWZkRrbEkydG9VTnFDUkViYVRk

WlkwUDI4LTlSblJENjhES044aUNodEdpQmowdFpjdUttazdUc0tZenVrZVh2YzRmamRoMm5nVTQw

NlpHbWRfQ2Y4MkhuNWRxV1pYMF9INDlGalZZcVJFYzlFUkVaOXFuYzdzdG9JYzZGejZvd0hGNHlE

eHJQYUxUZXlMYU82bk9wV3BUeTNjdzF1NkgxdkNBRG5mWWEwN0t1WnZwREhTR2tkZnc0bHQzd3pu

XzUtSmg4REw5X3BPRjVWSjJJZEpuMk9Za3A4c2Z0Tms1Q3BpSGJYMTByYkM2S2Vta1NuQWtibnZ1

Y0VsWEstQUdPTG80RTMxOVNJejVGZzdtRmlqTWpHaHdaRFVKc1JRYTB3aEpCRjVldkFVeU14NHRk

UjJ0eUZMVm05aWZBQ2xvb1VZU20xbGMycURidzVGck9nRURRV0xHcjdlQ1VNOHNsNHAyaTA2M05Q

akxwTXZHOER3clIxbW9sVFZXVkk3d0dJMU9Da2JaWVF2RTV1UkNWUVloa0pXaWV6aEZsb0k2WWlk

OUZNcW0tZ1JRQTBxZTNCZS10cjV3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHo0MDU8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA 40 Key points include use of age-adjusted D-dimer cut-off in preclinical risk assessment. Furthermore, categorization of PE events in “provoked” and “unprovoked” is no longer suggested. Rather, occurrence of index event in presence of “reversible risk factor,” or in absence of any “identifiable risk factor” is suggested for patient stratification and guidance of treatment duration. For the first time, direct oral anti-coagulants (DOACs) are recommended over vitamin K antagonists for PE treatment in eligible patients as for patients with atrial fibrillation. A reduced dose of apixaban or rivaroxaban for extended anticoagulation should be considered after the first 6 months of treatment. Edoxaban or rivaroxaban should be considered as an alternative to low molecular weight heparin in patients with non-gastrointestinal cancer who experience VTE. A new recommendation (class IIa, level A) proposes that carefully selected, low-risk PE patients should be considered for early discharge and home treatment, as long as proper outpatient care and anticoagulant therapy are possible (Figure 5). A recent prospective multicentre single-arm trial further corroborates this recommendation. Low-risk PE patients (no HESTIA criteria present, and absence of right ventricle enlargement/dysfunction) were early discharged (maximum of 2 nights in hospital) for home treatment with rivaroxaban. The study was prematurely terminated because of low symptomatic VTE recurrence and PE-related death rates (0.6%; one-sided upper 99.6% CI 2.1%), and low bleeding episodes (1.2%) at 3-months from diagnosis.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJjbzwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MDk0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

NDE8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDk0PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5MzYxNDEiPjQwOTQ8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJhcmNvLCBTLjwvYXV0aG9yPjxhdXRob3I+

U2NobWlkdG1hbm4sIEkuPC9hdXRob3I+PGF1dGhvcj5BZ2VubywgVy48L2F1dGhvcj48YXV0aG9y

PkJhdWVyc2FjaHMsIFIuIE0uPC9hdXRob3I+PGF1dGhvcj5CZWNhdHRpbmksIEMuPC9hdXRob3I+

PGF1dGhvcj5CZXJuYXJkaSwgRS48L2F1dGhvcj48YXV0aG9yPkJleWVyLVdlc3RlbmRvcmYsIEou

PC9hdXRob3I+PGF1dGhvcj5Cb25hY2NoaW5pLCBMLjwvYXV0aG9yPjxhdXRob3I+QnJhY2htYW5u

LCBKLjwvYXV0aG9yPjxhdXRob3I+Q2hyaXN0LCBNLjwvYXV0aG9yPjxhdXRob3I+Q3ppaGFsLCBN

LjwvYXV0aG9yPjxhdXRob3I+RHVlcnNjaG1pZWQsIEQuPC9hdXRob3I+PGF1dGhvcj5FbXBlbiwg

Sy48L2F1dGhvcj48YXV0aG9yPkVzcGlub2xhLUtsZWluLCBDLjwvYXV0aG9yPjxhdXRob3I+Rmlj

a2VyLCBKLiBILjwvYXV0aG9yPjxhdXRob3I+Rm9uc2VjYSwgQy48L2F1dGhvcj48YXV0aG9yPkdl

bnRoLVpvdHosIFMuPC9hdXRob3I+PGF1dGhvcj5KaW1lbmV6LCBELjwvYXV0aG9yPjxhdXRob3I+

SGFyam9sYSwgVi4gUC48L2F1dGhvcj48YXV0aG9yPkhlbGQsIE0uPC9hdXRob3I+PGF1dGhvcj5J

b2duYSBQcmF0LCBMLjwvYXV0aG9yPjxhdXRob3I+TGFuZ2UsIFQuIEouPC9hdXRob3I+PGF1dGhv

cj5NYW5vbGlzLCBBLjwvYXV0aG9yPjxhdXRob3I+TWV5ZXIsIEEuPC9hdXRob3I+PGF1dGhvcj5N

dXN0b25lbiwgUC48L2F1dGhvcj48YXV0aG9yPlJhdWNoLUtyb2VobmVydCwgVS48L2F1dGhvcj48

YXV0aG9yPlJ1aXotQXJ0YWNobywgUC48L2F1dGhvcj48YXV0aG9yPlNjaGVsbG9uZywgUy48L2F1

dGhvcj48YXV0aG9yPlNjaHdhaWJsbWFpciwgTS48L2F1dGhvcj48YXV0aG9yPlN0YWhyZW5iZXJn

LCBSLjwvYXV0aG9yPjxhdXRob3I+V2VzdGVyd2VlbCwgUC4gRS48L2F1dGhvcj48YXV0aG9yPldp

bGQsIFAuIFMuPC9hdXRob3I+PGF1dGhvcj5Lb25zdGFudGluaWRlcywgUy4gVi48L2F1dGhvcj48

YXV0aG9yPkxhbmtlaXQsIE0uPC9hdXRob3I+PGF1dGhvcj5IbywgVC4gUC4gRS4gSW52ZXN0aWdh

dG9yczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNlbnRl

ciBmb3IgVGhyb21ib3NpcyBhbmQgSGVtb3N0YXNpcyAoQ1RIKSwgVW5pdmVyc2l0eSBNZWRpY2Fs

IENlbnRlciBvZiB0aGUgSm9oYW5uZXMgR3V0ZW5iZXJnIFVuaXZlcnNpdHksIExhbmdlbmJlY2tz

dHJhc3NlIDEsIEJ1aWxkaW5nIDQwMywgNTUxMzEgTWFpbnosIEdlcm1hbnkuJiN4RDtJbnN0aXR1

dGUgb2YgTWVkaWNhbCBCaW9zdGF0aXN0aWNzLCBFcGlkZW1pb2xvZ3kgYW5kIEluZm9ybWF0aWNz

IChJTUJFSSksIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIgTWFpbnosIE9iZXJlIFphaGxiYWNo

ZXIgU3RyYXNzZSA2OSwgNTUxMzEgTWFpbnosIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIE1l

ZGljaW5lIGFuZCBTdXJnZXJ5LCBSZXNlYXJjaCBDZW50ZXIgb24gVGhyb21ib2VtYm9saWMgRGlz

ZWFzZXMgYW5kIEFudGl0aHJvbWJvdGljIFRoZXJhcGllcywgVW5pdmVyc2l0eSBvZiBJbnN1YnJp

YSwgVmlhbGUgTHVpZ2kgQm9ycmkgNTcsIDIxMTAwIFZhcmVzZSwgSXRhbHkuJiN4RDtEZXBhcnRt

ZW50IG9mIFZhc2N1bGFyIE1lZGljaW5lLCBLbGluaWt1bSBEYXJtc3RhZHQsIEdyYWZlbnN0cmFz

c2UgOSwgNjQyODMgRGFybXN0YWR0LCBHZXJtYW55LiYjeEQ7SW50ZXJuYWwgYW5kIENhcmRpb3Zh

c2N1bGFyIE1lZGljaW5lIC0gU3Ryb2tlIFVuaXQsIFVuaXZlcnNpdHkgb2YgUGVydWdpYSwgVmlh

IEcuIERvdHRvcmkgMSwgMDYxMjkgUGVydWdpYSwgSXRhbHkuJiN4RDtEZXBhcnRtZW50IG9mIEVt

ZXJnZW5jeSBNZWRpY2luZSwgVUxTUyBuLjcsIFZpYSBCcmlnYXRhIEJpc2Fnbm8gNCwgMzEwMTUg

Q29uZWdsaWFubyAoVHJldmlzbyksIEl0YWx5LiYjeEQ7VGhyb21ib3NpcyBSZXNlYXJjaCBVbml0

LCBEaXZpc2lvbiBvZiBIZW1hdG9sb2d5LCBEZXBhcnRtZW50IG9mIE1lZGljaW5lIEksIFVuaXZl

cnNpdHkgSG9zcGl0YWwgJnF1b3Q7Q2FybCBHdXN0YXYgQ2FydXMmcXVvdDssIEZldHNjaGVyc3Ry

YXNzZSA3NCwgMDEzMDcgRHJlc2RlbiwgR2VybWFueS4mI3hEO0tpbmdzIFRocm9tYm9zaXMgU2Vy

dmljZSwgRGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5LCBLaW5ncyBDb2xsZWdlIExvbmRvbiwgRGVu

bWFyayBIaWxsLCBCcml4dG9uLCBTRTUgOVJTLCBMb25kb24sIFVLLiYjeEQ7Uy5DLiBNZWRpY2lu

YSBkJmFwb3M7VXJnZW56YSBlIFByb250byBTb2Njb3JzbywgQVNTVCBHcmFuZGUgT3NwZWRhbGUg

TWV0cm9wb2xpdGFubyBOaWd1YXJkYSwgUGlhenphIGRlbGwmYXBvcztPc3BlZGFsZSBNYWdnaW9y

ZSAzLCAyMDE2MiBNaWxhbm8sIEl0YWx5LiYjeEQ7SUkgTWVkaWNhbCBEZXBhcnRtZW50LCBDb2J1

cmcgSG9zcGl0YWwsIEtldHNjaGVuZG9yZmVyIFN0cmFzc2UgMzMsIDk2NDUwIENvYnVyZywgR2Vy

bWFueS4mI3hEO0VtZXJnZW5jeSBDYXJlIChOb3RmYWxsemVudHJ1bSksIEx1emVybmVyIEthbnRv

bnNzcGl0YWwsIDYwMDAgTHV6ZXJuLCBTd2l0emVybGFuZC4mI3hEO0RpdmlzaW9uIG9mIFZhc2N1

bGFyIE1lZGljaW5lLCBIb3NwaXRhbCBvZiB0aGUgTHVkd2lnLU1heGltaWxpYW5zLVVuaXZlcnNp

dHksIEdlb3JnZW5zdHJhc3NlIDUsIDgwNzk5IE11bmljaCwgR2VybWFueS4mI3hEO0RlcGFydG1l

bnQgb2YgQ2FyZGlvbG9neSBhbmQgQW5naW9sb2d5IEksIEhlYXJ0IENlbnRlciwgRmFjdWx0eSBv

ZiBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBGcmVpYnVyZywgSHVnc3RldHRlciBTdHJhc3NlIDU1

LCA3OTEwNiBGcmVpYnVyZywgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVk

aWNpbmUsIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIEZsZWlzY2htYW5uc3RyYXNzZSA2LCAx

NzQ4OSBHcmVpZnN3YWxkLCBHZXJtYW55LiYjeEQ7Q2VudGVyIGZvciBDYXJkaW9sb2d5LCBDYXJk

aW9sb2d5IDEsIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIgb2YgdGhlIEpvaGFubmVzIEd1dGVu

YmVyZy1Vbml2ZXJzaXR5LCBMYW5nZW5iZWNrc3RyYXNzZSAxLCA1NTEzMSBNYWlueiwgR2VybWFu

eS4mI3hEO0RlcGFydG1lbnQgb2YgUmVzcGlyYXRvcnkgTWVkaWNpbmUsIE51cmVtYmVyZyBHZW5l

cmFsIEhvc3BpdGFsL1BhcmFjZWxzdXMgTWVkaWNhbCBVbml2ZXJzaXR5LCBQcm9mLi1Fcm5zdC1O

YXRoYW4tU3RyYXNzZSAxLCA5MDQxOSBOdXJlbWJlcmcsIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50

IG9mIEludGVybmFsIE1lZGljaW5lLCBIb3NwaXRhbCBTLiBGcmFuY2lzY28gWGF2aWVyL0NITE8s

IE5PVkEgTWVkaWNhbCBTY2hvb2wsIEZhY3VsZGFkZSBkZSBDaWVuY2lhcyBNZWRpY2FzLCBVbml2

ZXJzaWRhZGUgTm92YSBkZSBMaXNib2EsIENhbXBvIE1hcnRpcmVzIGRhIFBhdHJpYSAxMzAsIDEx

NjktMDU2IExpc2JvbiwgUG9ydHVnYWwuJiN4RDtEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGlj

aW5lIEksIEthdGhvbGlzY2hlcyBLbGluaWt1bSBNYWlueiwgQW4gZGVyIEdvbGRydWJlIDExLCA1

NTEzMSBNYWlueiwgR2VybWFueS4mI3hEO1Jlc3BpcmF0b3J5IERlcGFydG1lbnQsIFJhbW9uIHkg

Q2FqYWwgSG9zcGl0YWwsIFVuaXZlcnNpZGFkIGRlIEFsY2FsYSwgSVJZQ0lTLCBDdHJhLiBDb2xt

ZW5hciBWaWVqbywga20uIDksIDEwMCwgMjgwMzQgTWFkcmlkLCBTcGFpbi4mI3hEO0VtZXJnZW5j

eSBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBIZWxzaW5raSwgRGVwYXJ0bWVudCBvZiBFbWVyZ2Vu

Y3kgTWVkaWNpbmUgYW5kIFNlcnZpY2VzLCBIZWxzaW5raSBVbml2ZXJzaXR5IEhvc3BpdGFsLCBU

dWtob2xtYW5rYXR1IDhBLCAwMDI5MCBIZWxzaW5raSwgRmlubGFuZC4mI3hEO0RlcGFydG1lbnQg

b2YgSW50ZXJuYWwgTWVkaWNpbmUsIE1lZGljYWwgTWlzc2lvbiBIb3NwaXRhbCwgQWNhZGVtaWMg

VGVhY2hpbmcgSG9zcGl0YWwgb2YgdGhlIEp1bGl1cy1NYXhpbWlsaWFuIFVuaXZlcnNpdHkgb2Yg

V3VlcnpidXJnLCBKb3NlZi1TY2huZWlkZXItU3RyYXNzZSAyLCA5NzA4MCBXdWVyemJ1cmcsIEdl

cm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIEVtZXJnZW5jeSBNZWRpY2luZSwgU2FudGEgTWFyaWEg

ZGVsbGEgTWlzZXJpY29yZGlhIEhvc3BpdGFsLCBQaWF6emFsZSBTYW50YSBNYXJpYSBkZWxsYSBN

aXNlcmljb3JkaWEgMTUsIDMzMTAwIFVkaW5lLCBJdGFseS4mI3hEO0RlcGFydG1lbnQgb2YgSW50

ZXJuYWwgTWVkaWNpbmUgSUksIERpdmlzaW9uIG9mIFBuZXVtb2xvZ3ksIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIgUmVnZW5zYnVyZywgRnJhbnotSm9zZWYtU3RyYXVzcy1BbGxlZSAxMSwgOTMw

NTMgUmVnZW5zYnVyZywgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgR2Vu

ZXJhbCBIb3NwaXRhbCAmYXBvcztBc2tsZXBlaW9uIFZvdWxhcyZhcG9zOywgTGVvZi4gVmFzaWxl

b3MgUGF2bG91IDEsIDE2NiA3MyBBdGhlbnMsIEdyZWVjZS4mI3hEO0tsaW5pa2VuIE1hcmlhIEhp

bGYsIEtsaW5payBmdXIgUG5ldW1vbG9naWUsIEtyYW5rZW5oYXVzIFN0LiBGcmFuemlza3VzLCBW

aWVyc2VuZXIgU3RyLiA0NTAsIDQxMDYzIE1vbmNoZW5nbGFkYmFjaCwgR2VybWFueS4mI3hEO0Rl

cGFydG1lbnQgb2YgTWVkaWNpbmUsIEtlc2tpLVN1b21pIENlbnRyYWwgSG9zcGl0YWwgYW5kIFVu

aXZlcnNpdHkgb2YgSnl2YXNreWxhLCBLZXNrdXNzYWlyYWFsYW50aWUgMTksIDQwNjIwIEp5dmFz

a3lsYSwgRmlubGFuZC4mI3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgVW5pdmVyc2l0eSBI

ZWFydCBDZW50ZXIgQmVybGluLCBDaGFyaXRlIFVuaXZlcnNpdGF0c21lZGl6aW4gQmVybGluLCBD

aGFyaXRlcGxhdHogMSwgMTAxMTcgQmVybGluLCBHZXJtYW55OyBHZXJtYW4gQ2VudGVyIGZvciBD

YXJkaW92YXNjdWxhciBSZXNlYXJjaCAoRFpISyksIEJlcmxpbiwgR2VybWFueS4mI3hEO0VtZXJn

ZW5jeSBEZXBhcnRtZW50LCBDbGluaWNvIFNhbiBDYXJsb3MgSG9zcGl0YWwsIElkSVNTQywgYWxs

ZSBkZWwgUHJvZiBNYXJ0aW4gTGFnb3MsIHMvbiwgMjgwNDAgTWFkcmlkLCBTcGFpbi4mI3hEO0lu

dGVybmFsIE1lZGljaW5lIERlcGFydG1lbnQsIFVuaXZlcnNpdHkgQ2xpbmljIG9mIE5hdmFycmEs

IENhbGxlIE1hcnF1ZXNhZG8gZGUgU3RhLiBNYXJ0YSAxLCAyODAyNyBNYWRyaWQsIFNwYWluLiYj

eEQ7VmFzY3VsYXIgQ2VudGVyLCBNdW5pY2lwYWwgSG9zcGl0YWwgb2YgRHJlc2Rlbi1GcmllZHJp

Y2hzdGFkdCwgRnJpZWRyaWNoc3RyYXNzZSA0MSwgMDEwNjcgRHJlc2RlbiwgR2VybWFueS4mI3hE

O0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgUmVzcGlyYXRvcnkgTWVkaWNpbmUgYW5kIEludGVu

c2l2ZSBDYXJlLCBLbGluaWt1bSBBdWdzYnVyZywgTHVkd2lnLU1heGltaWxpYW5zLVVuaXZlcnNp

dHkgTXVuaWNoLCBTdGVuZ2xpbnN0cmFzc2UgMiwgODYxNTYgTXVuaWNoLCBHZXJtYW55LiYjeEQ7

SGVsaW9zIEFsYmVydC1TY2h3ZWl0emVyLUtsaW5paywgQWxiZXJ0LVNjaHdlaXR6ZXItV2VnIDEs

IDM3MTU0IE5vcnRoZWltLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRp

Y2luZSwgQWxiZXJ0IFNjaHdlaXR6ZXIgSG9zcGl0YWwsIEFsYmVydCBTY2h3ZWl0emVycGxhYXRz

IDI1LCAzMzE4IEFUIERvcmRyZWNodCwgVGhlIE5ldGhlcmxhbmRzLiYjeEQ7R2VybWFuIENlbnRl

ciBmb3IgQ2FyZGlvdmFzY3VsYXIgUmVzZWFyY2ggKERaSEspLCBQYXJ0bmVyIFNpdGUgUmhpbmUg

TWFpbiwgTWFpbnosIEdlcm1hbnkuJiN4RDtDZW50ZXIgZm9yIENhcmRpb2xvZ3ksIFByZXZlbnRp

dmUgQ2FyZGlvbG9neSBhbmQgUHJldmVudGl2ZSBNZWRpY2luZSwgVW5pdmVyc2l0eSBNZWRpY2Fs

IENlbnRlciBvZiB0aGUgSm9oYW5uZXMgR3V0ZW5iZXJnIFVuaXZlcnNpdHksIExhbmdlbmJlY2tz

dHJhc3NlIDEsIDU1MTMxIE1haW56LCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9s

b2d5LCBEZW1vY3JpdHVzIFVuaXZlcnNpdHkgb2YgVGhyYWNlLCA2ODEwMCBBbGV4YW5kcm91cG9s

aXMsIEdyZWVjZS4mI3hEO0RlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUgYW5kIENhcmRp

b2xvZ3ksIENhbXB1cyBWaXJjaG93IEtsaW5pa3VtLCBDaGFyaXRlIC0gVW5pdmVyc2l0eSBNZWRp

Y2luZSBCZXJsaW4sIEF1Z3VzdGVuYnVyZ2VycGxhdHogMSwgMTMzNTMgQmVybGluLCBHZXJtYW55

LiYjeEQ7Q2xpbmljIG9mIENhcmRpb2xvZ3kgYW5kIFBuZXVtb2xvZ3ksIEhlYXJ0IENlbnRlciwg

VW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciBHb2V0dGluZ2VuLCBSb2JlcnQtS29jaC1TdHJhc3Nl

IDQwLCAzNzA3NSBHb2V0dGluZ2VuLCBHZXJtYW55LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPkVhcmx5IGRpc2NoYXJnZSBhbmQgaG9tZSB0cmVhdG1lbnQgb2YgcGF0aWVudHMgd2l0aCBs

b3ctcmlzayBwdWxtb25hcnkgZW1ib2xpc20gd2l0aCB0aGUgb3JhbCBmYWN0b3IgWGEgaW5oaWJp

dG9yIHJpdmFyb3hhYmFuOiBhbiBpbnRlcm5hdGlvbmFsIG11bHRpY2VudHJlIHNpbmdsZS1hcm0g

Y2xpbmljYWwgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29u

ZGFyeS10aXRsZT48L3RpdGxlcz48a2V5d29yZHM+PGtleXdvcmQ+SG9tZSB0cmVhdG1lbnQ8L2tl

eXdvcmQ+PGtleXdvcmQ+TWFuYWdlbWVudCB0cmlhbDwva2V5d29yZD48a2V5d29yZD5QdWxtb25h

cnkgZW1ib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+UmlnaHQgdmVudHJpY3VsYXIgZHlzZnVuY3Rp

b248L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBzdHJhdGlmaWNhdGlvbjwva2V5d29yZD48a2V5d29y

ZD5SaXZhcm94YWJhbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+TWF5IDIzPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNj

ZXNzaW9uLW51bT4zMTEyMDExODwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1

cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzExMjAxMTg8L3VybD48dXJs

Pmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9laHozNjcucGRmP3Rva2VuPUFRRUNB

SGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBcFl3Z2dLU0Jn

a3Foa2lHOXcwQkJ3YWdnZ0tETUlJQ2Z3SUJBRENDQW5nR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtn

QlpRTUVBUzR3RVFRTTlqVmYzWlhYd3hVb3RLZ2FBZ0VRZ0lJQ1NXMm9MblZONThuLUVyNHlyVE9n

dHdTSWJEbFRzNElTN29STFRKS0JtYmJPMWwxNFk0Yk1LLUJqQkF0LXZvN2s2YUtHbWN2UFJiTU44

dktfWU1tNUdzYl9ZZ2dFU0NFTXhzRl9nM2lJWkgtNC1xZUUtc3V3Qlktb2I3STdGdGNPUHVTQ3k3

RUo1SkNaRTYycHJSRVdvTzNEcEFrZFhvOWN0ZVQxTVdta0xGYWJhMW9fMkVZM0prZW4tVjhmeGNa

WUxfNUpTdHRMTDV0Zjkta2E0aWs2NGg4R19Bd0FYclY3c3ViVXp3YzFCcUxEWktjRk54Y29GY0FW

TGktMFlRYkVXSElNWE5ta3VsT0tvM0l3Ulh0N2xYdzVYWWdKQ2Nsa3V4WGg0VXpWTzdSZFVZR0Et

MU1TaVctZmozTEJsd3E1X2tKa3dWM09YTTByZFZJUDVmTjR4Z3ZFNVkxLTUtOVBmVmxUZC1tZ01D

VXVjWW1qR2hNcUJWRkVIRV9vTXJRS2xtN3R0VDlZU3JOd2I0V1NtNDJqYzM2Q18zMDgyOXBUSjRJ

QWtONVE2S1RFMHlpNHRIWmdqUHA3NTRGT2xCY1M5YTdKUEs0UkxkajI1SHdtNFU2WlNhTjIxZEl4

RWdObzM0R1hveDZkQkwwd2Vaa0tUblNmbDFIMFNPV1kzNEt3c0pJU3M2NFltd3FjTk55RmJyYnds

UjRaUnFCMnE4dDdhS1FQa0hROW14cm53SzhFSXJraVpBNUtUbk5mZHBqNHpCOHZ6NFNueWNzNjhT

cDFjbGNEOVJUTEtJTHQ4UDhuWGg2RE1xOXpKSXFIN0dkelBxQ202eS11eVpYRFAyMTNlcXFQc1pG

WnFJMllnMmF0c1Y5Y2g4LVNudVJVVU92bW1oQkpXdmJ3Q3lUMnNwcXRMYk96cjdyV1J3ZmRka19I

eU9wd3RwOWxSS0MteUFjRU80UGJWTHFHdHZkREI0QVpKOUFvZktfUHNtODYyVDJnVkpXd04wNEpF

TUhnVkhRSHh1MWpQT0ZEdHlybEd3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHozNjc8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJjbzwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MDk0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

NDE8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDk0PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5MzYxNDEiPjQwOTQ8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJhcmNvLCBTLjwvYXV0aG9yPjxhdXRob3I+

U2NobWlkdG1hbm4sIEkuPC9hdXRob3I+PGF1dGhvcj5BZ2VubywgVy48L2F1dGhvcj48YXV0aG9y

PkJhdWVyc2FjaHMsIFIuIE0uPC9hdXRob3I+PGF1dGhvcj5CZWNhdHRpbmksIEMuPC9hdXRob3I+

PGF1dGhvcj5CZXJuYXJkaSwgRS48L2F1dGhvcj48YXV0aG9yPkJleWVyLVdlc3RlbmRvcmYsIEou

PC9hdXRob3I+PGF1dGhvcj5Cb25hY2NoaW5pLCBMLjwvYXV0aG9yPjxhdXRob3I+QnJhY2htYW5u

LCBKLjwvYXV0aG9yPjxhdXRob3I+Q2hyaXN0LCBNLjwvYXV0aG9yPjxhdXRob3I+Q3ppaGFsLCBN

LjwvYXV0aG9yPjxhdXRob3I+RHVlcnNjaG1pZWQsIEQuPC9hdXRob3I+PGF1dGhvcj5FbXBlbiwg

Sy48L2F1dGhvcj48YXV0aG9yPkVzcGlub2xhLUtsZWluLCBDLjwvYXV0aG9yPjxhdXRob3I+Rmlj

a2VyLCBKLiBILjwvYXV0aG9yPjxhdXRob3I+Rm9uc2VjYSwgQy48L2F1dGhvcj48YXV0aG9yPkdl

bnRoLVpvdHosIFMuPC9hdXRob3I+PGF1dGhvcj5KaW1lbmV6LCBELjwvYXV0aG9yPjxhdXRob3I+

SGFyam9sYSwgVi4gUC48L2F1dGhvcj48YXV0aG9yPkhlbGQsIE0uPC9hdXRob3I+PGF1dGhvcj5J

b2duYSBQcmF0LCBMLjwvYXV0aG9yPjxhdXRob3I+TGFuZ2UsIFQuIEouPC9hdXRob3I+PGF1dGhv

cj5NYW5vbGlzLCBBLjwvYXV0aG9yPjxhdXRob3I+TWV5ZXIsIEEuPC9hdXRob3I+PGF1dGhvcj5N

dXN0b25lbiwgUC48L2F1dGhvcj48YXV0aG9yPlJhdWNoLUtyb2VobmVydCwgVS48L2F1dGhvcj48

YXV0aG9yPlJ1aXotQXJ0YWNobywgUC48L2F1dGhvcj48YXV0aG9yPlNjaGVsbG9uZywgUy48L2F1

dGhvcj48YXV0aG9yPlNjaHdhaWJsbWFpciwgTS48L2F1dGhvcj48YXV0aG9yPlN0YWhyZW5iZXJn

LCBSLjwvYXV0aG9yPjxhdXRob3I+V2VzdGVyd2VlbCwgUC4gRS48L2F1dGhvcj48YXV0aG9yPldp

bGQsIFAuIFMuPC9hdXRob3I+PGF1dGhvcj5Lb25zdGFudGluaWRlcywgUy4gVi48L2F1dGhvcj48

YXV0aG9yPkxhbmtlaXQsIE0uPC9hdXRob3I+PGF1dGhvcj5IbywgVC4gUC4gRS4gSW52ZXN0aWdh

dG9yczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNlbnRl

ciBmb3IgVGhyb21ib3NpcyBhbmQgSGVtb3N0YXNpcyAoQ1RIKSwgVW5pdmVyc2l0eSBNZWRpY2Fs

IENlbnRlciBvZiB0aGUgSm9oYW5uZXMgR3V0ZW5iZXJnIFVuaXZlcnNpdHksIExhbmdlbmJlY2tz

dHJhc3NlIDEsIEJ1aWxkaW5nIDQwMywgNTUxMzEgTWFpbnosIEdlcm1hbnkuJiN4RDtJbnN0aXR1

dGUgb2YgTWVkaWNhbCBCaW9zdGF0aXN0aWNzLCBFcGlkZW1pb2xvZ3kgYW5kIEluZm9ybWF0aWNz

IChJTUJFSSksIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIgTWFpbnosIE9iZXJlIFphaGxiYWNo

ZXIgU3RyYXNzZSA2OSwgNTUxMzEgTWFpbnosIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIE1l

ZGljaW5lIGFuZCBTdXJnZXJ5LCBSZXNlYXJjaCBDZW50ZXIgb24gVGhyb21ib2VtYm9saWMgRGlz

ZWFzZXMgYW5kIEFudGl0aHJvbWJvdGljIFRoZXJhcGllcywgVW5pdmVyc2l0eSBvZiBJbnN1YnJp

YSwgVmlhbGUgTHVpZ2kgQm9ycmkgNTcsIDIxMTAwIFZhcmVzZSwgSXRhbHkuJiN4RDtEZXBhcnRt

ZW50IG9mIFZhc2N1bGFyIE1lZGljaW5lLCBLbGluaWt1bSBEYXJtc3RhZHQsIEdyYWZlbnN0cmFz

c2UgOSwgNjQyODMgRGFybXN0YWR0LCBHZXJtYW55LiYjeEQ7SW50ZXJuYWwgYW5kIENhcmRpb3Zh

c2N1bGFyIE1lZGljaW5lIC0gU3Ryb2tlIFVuaXQsIFVuaXZlcnNpdHkgb2YgUGVydWdpYSwgVmlh

IEcuIERvdHRvcmkgMSwgMDYxMjkgUGVydWdpYSwgSXRhbHkuJiN4RDtEZXBhcnRtZW50IG9mIEVt

ZXJnZW5jeSBNZWRpY2luZSwgVUxTUyBuLjcsIFZpYSBCcmlnYXRhIEJpc2Fnbm8gNCwgMzEwMTUg

Q29uZWdsaWFubyAoVHJldmlzbyksIEl0YWx5LiYjeEQ7VGhyb21ib3NpcyBSZXNlYXJjaCBVbml0

LCBEaXZpc2lvbiBvZiBIZW1hdG9sb2d5LCBEZXBhcnRtZW50IG9mIE1lZGljaW5lIEksIFVuaXZl

cnNpdHkgSG9zcGl0YWwgJnF1b3Q7Q2FybCBHdXN0YXYgQ2FydXMmcXVvdDssIEZldHNjaGVyc3Ry

YXNzZSA3NCwgMDEzMDcgRHJlc2RlbiwgR2VybWFueS4mI3hEO0tpbmdzIFRocm9tYm9zaXMgU2Vy

dmljZSwgRGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5LCBLaW5ncyBDb2xsZWdlIExvbmRvbiwgRGVu

bWFyayBIaWxsLCBCcml4dG9uLCBTRTUgOVJTLCBMb25kb24sIFVLLiYjeEQ7Uy5DLiBNZWRpY2lu

YSBkJmFwb3M7VXJnZW56YSBlIFByb250byBTb2Njb3JzbywgQVNTVCBHcmFuZGUgT3NwZWRhbGUg

TWV0cm9wb2xpdGFubyBOaWd1YXJkYSwgUGlhenphIGRlbGwmYXBvcztPc3BlZGFsZSBNYWdnaW9y

ZSAzLCAyMDE2MiBNaWxhbm8sIEl0YWx5LiYjeEQ7SUkgTWVkaWNhbCBEZXBhcnRtZW50LCBDb2J1

cmcgSG9zcGl0YWwsIEtldHNjaGVuZG9yZmVyIFN0cmFzc2UgMzMsIDk2NDUwIENvYnVyZywgR2Vy

bWFueS4mI3hEO0VtZXJnZW5jeSBDYXJlIChOb3RmYWxsemVudHJ1bSksIEx1emVybmVyIEthbnRv

bnNzcGl0YWwsIDYwMDAgTHV6ZXJuLCBTd2l0emVybGFuZC4mI3hEO0RpdmlzaW9uIG9mIFZhc2N1

bGFyIE1lZGljaW5lLCBIb3NwaXRhbCBvZiB0aGUgTHVkd2lnLU1heGltaWxpYW5zLVVuaXZlcnNp

dHksIEdlb3JnZW5zdHJhc3NlIDUsIDgwNzk5IE11bmljaCwgR2VybWFueS4mI3hEO0RlcGFydG1l

bnQgb2YgQ2FyZGlvbG9neSBhbmQgQW5naW9sb2d5IEksIEhlYXJ0IENlbnRlciwgRmFjdWx0eSBv

ZiBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBGcmVpYnVyZywgSHVnc3RldHRlciBTdHJhc3NlIDU1

LCA3OTEwNiBGcmVpYnVyZywgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVk

aWNpbmUsIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIEZsZWlzY2htYW5uc3RyYXNzZSA2LCAx

NzQ4OSBHcmVpZnN3YWxkLCBHZXJtYW55LiYjeEQ7Q2VudGVyIGZvciBDYXJkaW9sb2d5LCBDYXJk

aW9sb2d5IDEsIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIgb2YgdGhlIEpvaGFubmVzIEd1dGVu

YmVyZy1Vbml2ZXJzaXR5LCBMYW5nZW5iZWNrc3RyYXNzZSAxLCA1NTEzMSBNYWlueiwgR2VybWFu

eS4mI3hEO0RlcGFydG1lbnQgb2YgUmVzcGlyYXRvcnkgTWVkaWNpbmUsIE51cmVtYmVyZyBHZW5l

cmFsIEhvc3BpdGFsL1BhcmFjZWxzdXMgTWVkaWNhbCBVbml2ZXJzaXR5LCBQcm9mLi1Fcm5zdC1O

YXRoYW4tU3RyYXNzZSAxLCA5MDQxOSBOdXJlbWJlcmcsIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50

IG9mIEludGVybmFsIE1lZGljaW5lLCBIb3NwaXRhbCBTLiBGcmFuY2lzY28gWGF2aWVyL0NITE8s

IE5PVkEgTWVkaWNhbCBTY2hvb2wsIEZhY3VsZGFkZSBkZSBDaWVuY2lhcyBNZWRpY2FzLCBVbml2

ZXJzaWRhZGUgTm92YSBkZSBMaXNib2EsIENhbXBvIE1hcnRpcmVzIGRhIFBhdHJpYSAxMzAsIDEx

NjktMDU2IExpc2JvbiwgUG9ydHVnYWwuJiN4RDtEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGlj

aW5lIEksIEthdGhvbGlzY2hlcyBLbGluaWt1bSBNYWlueiwgQW4gZGVyIEdvbGRydWJlIDExLCA1

NTEzMSBNYWlueiwgR2VybWFueS4mI3hEO1Jlc3BpcmF0b3J5IERlcGFydG1lbnQsIFJhbW9uIHkg

Q2FqYWwgSG9zcGl0YWwsIFVuaXZlcnNpZGFkIGRlIEFsY2FsYSwgSVJZQ0lTLCBDdHJhLiBDb2xt

ZW5hciBWaWVqbywga20uIDksIDEwMCwgMjgwMzQgTWFkcmlkLCBTcGFpbi4mI3hEO0VtZXJnZW5j

eSBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBIZWxzaW5raSwgRGVwYXJ0bWVudCBvZiBFbWVyZ2Vu

Y3kgTWVkaWNpbmUgYW5kIFNlcnZpY2VzLCBIZWxzaW5raSBVbml2ZXJzaXR5IEhvc3BpdGFsLCBU

dWtob2xtYW5rYXR1IDhBLCAwMDI5MCBIZWxzaW5raSwgRmlubGFuZC4mI3hEO0RlcGFydG1lbnQg

b2YgSW50ZXJuYWwgTWVkaWNpbmUsIE1lZGljYWwgTWlzc2lvbiBIb3NwaXRhbCwgQWNhZGVtaWMg

VGVhY2hpbmcgSG9zcGl0YWwgb2YgdGhlIEp1bGl1cy1NYXhpbWlsaWFuIFVuaXZlcnNpdHkgb2Yg

V3VlcnpidXJnLCBKb3NlZi1TY2huZWlkZXItU3RyYXNzZSAyLCA5NzA4MCBXdWVyemJ1cmcsIEdl

cm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIEVtZXJnZW5jeSBNZWRpY2luZSwgU2FudGEgTWFyaWEg

ZGVsbGEgTWlzZXJpY29yZGlhIEhvc3BpdGFsLCBQaWF6emFsZSBTYW50YSBNYXJpYSBkZWxsYSBN

aXNlcmljb3JkaWEgMTUsIDMzMTAwIFVkaW5lLCBJdGFseS4mI3hEO0RlcGFydG1lbnQgb2YgSW50

ZXJuYWwgTWVkaWNpbmUgSUksIERpdmlzaW9uIG9mIFBuZXVtb2xvZ3ksIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIgUmVnZW5zYnVyZywgRnJhbnotSm9zZWYtU3RyYXVzcy1BbGxlZSAxMSwgOTMw

NTMgUmVnZW5zYnVyZywgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgR2Vu

ZXJhbCBIb3NwaXRhbCAmYXBvcztBc2tsZXBlaW9uIFZvdWxhcyZhcG9zOywgTGVvZi4gVmFzaWxl

b3MgUGF2bG91IDEsIDE2NiA3MyBBdGhlbnMsIEdyZWVjZS4mI3hEO0tsaW5pa2VuIE1hcmlhIEhp

bGYsIEtsaW5payBmdXIgUG5ldW1vbG9naWUsIEtyYW5rZW5oYXVzIFN0LiBGcmFuemlza3VzLCBW

aWVyc2VuZXIgU3RyLiA0NTAsIDQxMDYzIE1vbmNoZW5nbGFkYmFjaCwgR2VybWFueS4mI3hEO0Rl

cGFydG1lbnQgb2YgTWVkaWNpbmUsIEtlc2tpLVN1b21pIENlbnRyYWwgSG9zcGl0YWwgYW5kIFVu

aXZlcnNpdHkgb2YgSnl2YXNreWxhLCBLZXNrdXNzYWlyYWFsYW50aWUgMTksIDQwNjIwIEp5dmFz

a3lsYSwgRmlubGFuZC4mI3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgVW5pdmVyc2l0eSBI

ZWFydCBDZW50ZXIgQmVybGluLCBDaGFyaXRlIFVuaXZlcnNpdGF0c21lZGl6aW4gQmVybGluLCBD

aGFyaXRlcGxhdHogMSwgMTAxMTcgQmVybGluLCBHZXJtYW55OyBHZXJtYW4gQ2VudGVyIGZvciBD

YXJkaW92YXNjdWxhciBSZXNlYXJjaCAoRFpISyksIEJlcmxpbiwgR2VybWFueS4mI3hEO0VtZXJn

ZW5jeSBEZXBhcnRtZW50LCBDbGluaWNvIFNhbiBDYXJsb3MgSG9zcGl0YWwsIElkSVNTQywgYWxs

ZSBkZWwgUHJvZiBNYXJ0aW4gTGFnb3MsIHMvbiwgMjgwNDAgTWFkcmlkLCBTcGFpbi4mI3hEO0lu

dGVybmFsIE1lZGljaW5lIERlcGFydG1lbnQsIFVuaXZlcnNpdHkgQ2xpbmljIG9mIE5hdmFycmEs

IENhbGxlIE1hcnF1ZXNhZG8gZGUgU3RhLiBNYXJ0YSAxLCAyODAyNyBNYWRyaWQsIFNwYWluLiYj

eEQ7VmFzY3VsYXIgQ2VudGVyLCBNdW5pY2lwYWwgSG9zcGl0YWwgb2YgRHJlc2Rlbi1GcmllZHJp

Y2hzdGFkdCwgRnJpZWRyaWNoc3RyYXNzZSA0MSwgMDEwNjcgRHJlc2RlbiwgR2VybWFueS4mI3hE

O0RlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgUmVzcGlyYXRvcnkgTWVkaWNpbmUgYW5kIEludGVu

c2l2ZSBDYXJlLCBLbGluaWt1bSBBdWdzYnVyZywgTHVkd2lnLU1heGltaWxpYW5zLVVuaXZlcnNp

dHkgTXVuaWNoLCBTdGVuZ2xpbnN0cmFzc2UgMiwgODYxNTYgTXVuaWNoLCBHZXJtYW55LiYjeEQ7

SGVsaW9zIEFsYmVydC1TY2h3ZWl0emVyLUtsaW5paywgQWxiZXJ0LVNjaHdlaXR6ZXItV2VnIDEs

IDM3MTU0IE5vcnRoZWltLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRp

Y2luZSwgQWxiZXJ0IFNjaHdlaXR6ZXIgSG9zcGl0YWwsIEFsYmVydCBTY2h3ZWl0emVycGxhYXRz

IDI1LCAzMzE4IEFUIERvcmRyZWNodCwgVGhlIE5ldGhlcmxhbmRzLiYjeEQ7R2VybWFuIENlbnRl

ciBmb3IgQ2FyZGlvdmFzY3VsYXIgUmVzZWFyY2ggKERaSEspLCBQYXJ0bmVyIFNpdGUgUmhpbmUg

TWFpbiwgTWFpbnosIEdlcm1hbnkuJiN4RDtDZW50ZXIgZm9yIENhcmRpb2xvZ3ksIFByZXZlbnRp

dmUgQ2FyZGlvbG9neSBhbmQgUHJldmVudGl2ZSBNZWRpY2luZSwgVW5pdmVyc2l0eSBNZWRpY2Fs

IENlbnRlciBvZiB0aGUgSm9oYW5uZXMgR3V0ZW5iZXJnIFVuaXZlcnNpdHksIExhbmdlbmJlY2tz

dHJhc3NlIDEsIDU1MTMxIE1haW56LCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9s

b2d5LCBEZW1vY3JpdHVzIFVuaXZlcnNpdHkgb2YgVGhyYWNlLCA2ODEwMCBBbGV4YW5kcm91cG9s

aXMsIEdyZWVjZS4mI3hEO0RlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUgYW5kIENhcmRp

b2xvZ3ksIENhbXB1cyBWaXJjaG93IEtsaW5pa3VtLCBDaGFyaXRlIC0gVW5pdmVyc2l0eSBNZWRp

Y2luZSBCZXJsaW4sIEF1Z3VzdGVuYnVyZ2VycGxhdHogMSwgMTMzNTMgQmVybGluLCBHZXJtYW55

LiYjeEQ7Q2xpbmljIG9mIENhcmRpb2xvZ3kgYW5kIFBuZXVtb2xvZ3ksIEhlYXJ0IENlbnRlciwg

VW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciBHb2V0dGluZ2VuLCBSb2JlcnQtS29jaC1TdHJhc3Nl

IDQwLCAzNzA3NSBHb2V0dGluZ2VuLCBHZXJtYW55LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPkVhcmx5IGRpc2NoYXJnZSBhbmQgaG9tZSB0cmVhdG1lbnQgb2YgcGF0aWVudHMgd2l0aCBs

b3ctcmlzayBwdWxtb25hcnkgZW1ib2xpc20gd2l0aCB0aGUgb3JhbCBmYWN0b3IgWGEgaW5oaWJp

dG9yIHJpdmFyb3hhYmFuOiBhbiBpbnRlcm5hdGlvbmFsIG11bHRpY2VudHJlIHNpbmdsZS1hcm0g

Y2xpbmljYWwgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29u

ZGFyeS10aXRsZT48L3RpdGxlcz48a2V5d29yZHM+PGtleXdvcmQ+SG9tZSB0cmVhdG1lbnQ8L2tl

eXdvcmQ+PGtleXdvcmQ+TWFuYWdlbWVudCB0cmlhbDwva2V5d29yZD48a2V5d29yZD5QdWxtb25h

cnkgZW1ib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+UmlnaHQgdmVudHJpY3VsYXIgZHlzZnVuY3Rp

b248L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBzdHJhdGlmaWNhdGlvbjwva2V5d29yZD48a2V5d29y

ZD5SaXZhcm94YWJhbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+TWF5IDIzPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNj

ZXNzaW9uLW51bT4zMTEyMDExODwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1

cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzExMjAxMTg8L3VybD48dXJs

Pmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9laHozNjcucGRmP3Rva2VuPUFRRUNB

SGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3FmS0FjNDg1eXNnQUFBcFl3Z2dLU0Jn

a3Foa2lHOXcwQkJ3YWdnZ0tETUlJQ2Z3SUJBRENDQW5nR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtn

QlpRTUVBUzR3RVFRTTlqVmYzWlhYd3hVb3RLZ2FBZ0VRZ0lJQ1NXMm9MblZONThuLUVyNHlyVE9n

dHdTSWJEbFRzNElTN29STFRKS0JtYmJPMWwxNFk0Yk1LLUJqQkF0LXZvN2s2YUtHbWN2UFJiTU44

dktfWU1tNUdzYl9ZZ2dFU0NFTXhzRl9nM2lJWkgtNC1xZUUtc3V3Qlktb2I3STdGdGNPUHVTQ3k3

RUo1SkNaRTYycHJSRVdvTzNEcEFrZFhvOWN0ZVQxTVdta0xGYWJhMW9fMkVZM0prZW4tVjhmeGNa

WUxfNUpTdHRMTDV0Zjkta2E0aWs2NGg4R19Bd0FYclY3c3ViVXp3YzFCcUxEWktjRk54Y29GY0FW

TGktMFlRYkVXSElNWE5ta3VsT0tvM0l3Ulh0N2xYdzVYWWdKQ2Nsa3V4WGg0VXpWTzdSZFVZR0Et

MU1TaVctZmozTEJsd3E1X2tKa3dWM09YTTByZFZJUDVmTjR4Z3ZFNVkxLTUtOVBmVmxUZC1tZ01D

VXVjWW1qR2hNcUJWRkVIRV9vTXJRS2xtN3R0VDlZU3JOd2I0V1NtNDJqYzM2Q18zMDgyOXBUSjRJ

QWtONVE2S1RFMHlpNHRIWmdqUHA3NTRGT2xCY1M5YTdKUEs0UkxkajI1SHdtNFU2WlNhTjIxZEl4

RWdObzM0R1hveDZkQkwwd2Vaa0tUblNmbDFIMFNPV1kzNEt3c0pJU3M2NFltd3FjTk55RmJyYnds

UjRaUnFCMnE4dDdhS1FQa0hROW14cm53SzhFSXJraVpBNUtUbk5mZHBqNHpCOHZ6NFNueWNzNjhT

cDFjbGNEOVJUTEtJTHQ4UDhuWGg2RE1xOXpKSXFIN0dkelBxQ202eS11eVpYRFAyMTNlcXFQc1pG

WnFJMllnMmF0c1Y5Y2g4LVNudVJVVU92bW1oQkpXdmJ3Q3lUMnNwcXRMYk96cjdyV1J3ZmRka19I

eU9wd3RwOWxSS0MteUFjRU80UGJWTHFHdHZkREI0QVpKOUFvZktfUHNtODYyVDJnVkpXd04wNEpF

TUhnVkhRSHh1MWpQT0ZEdHlybEd3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDkzL2V1cmhlYXJ0ai9laHozNjc8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA 41 Careful selection of low-risk PE patients is key in successful home-treatment; in this regard, clinical severity scores alone may not be sufficient to identify such low-risk group especially with regard to subclinical RV dysfunction exclusion. Therefore, combining right ventricle assessment to clinical criteria further allow proper risk stratification as recently suggested by Barco et al..PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJjbzwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MDk2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

NDI8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDk2PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5MzY2NjkiPjQwOTY8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJhcmNvLCBTLjwvYXV0aG9yPjxhdXRob3I+

TWFobW91ZHBvdXIsIFMuIEguPC9hdXRob3I+PGF1dGhvcj5QbGFucXVldHRlLCBCLjwvYXV0aG9y

PjxhdXRob3I+U2FuY2hleiwgTy48L2F1dGhvcj48YXV0aG9yPktvbnN0YW50aW5pZGVzLCBTLiBW

LjwvYXV0aG9yPjxhdXRob3I+TWV5ZXIsIEcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+Q2VudGVyIGZvciBUaHJvbWJvc2lzIGFuZCBIYWVtb3N0YXNpcyAo

Q1RIKSwgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRyZSBvZiB0aGUgSm9oYW5uZXMgR3V0ZW5iZXJn

IFVuaXZlcnNpdHksIExhbmdlbmJlY2tzdHJhc3NlIDEsIE1haW56LCBHZXJtYW55LiYjeEQ7RGVw

YXJ0bWVudCBvZiBCaW9tZXRyeSBhbmQgQmlvaW5mb3JtYXRpY3MsIEluc3RpdHV0ZSBmb3IgTWVk

aWNhbCBCaW9zdGF0aXN0aWNzLCBFcGlkZW1pb2xvZ3ksIGFuZCBJbmZvcm1hdGljcyAoSU1CRUkp

LCBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudHJlIG9mIHRoZSBKb2hhbm5lcyBHdXRlbmJlcmcgVW5p

dmVyc2l0eSwgT2JlcmUgWmFobGJhY2hlciBTdHJhc3NlIDY5LCBNYWlueiwgR2VybWFueS4mI3hE

O0YtQ1JJTiBJTk5PVlRFLCBIb3BpdGFsIE5vcmQsIENIVSBTYWludCBFdGllbm5lLCBBdmVudWUg

QWxiZXJ0IFJhaW1vbmQsIFNhaW50IFByaWVzdCBlbiBKYXJleiAoU2FpbnQgRXRpZW5uZSksIEZy

YW5jZS4mI3hEO1NlcnZpY2UgZGUgUG5ldW1vbG9naWUgZXQgZGUgU29pbnMgSW50ZW5zaWZzLCBI

b3BpdGFsIEV1cm9wZWVuIEdlb3JnZXMgUG9tcGlkb3UsIEFQLUhQLCBVbml2ZXJzaXRlIFBhcmlz

IERlc2NhcnRlcywgU29yYm9ubmUgUGFyaXMgQ2l0ZSwgSU5TRVJNIFVNUiBTIDExNDAsIDIwIHJ1

ZSBMZWJsYW5jLCBQYXJpcywgRnJhbmNlLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBE

ZW1vY3JpdHVzIFVuaXZlcnNpdHkgb2YgVGhyYWNlLCBVbml2ZXJzaXR5IEdlbmVyYWwgSG9zcGl0

YWwsIEFsZXhhbmRyb3Vwb2xpcywgR3JlZWNlLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PlByb2dub3N0aWMgdmFsdWUgb2YgcmlnaHQgdmVudHJpY3VsYXIgZHlzZnVuY3Rpb24gb3IgZWxl

dmF0ZWQgY2FyZGlhYyBiaW9tYXJrZXJzIGluIHBhdGllbnRzIHdpdGggbG93LXJpc2sgcHVsbW9u

YXJ5IGVtYm9saXNtOiBhIHN5c3RlbWF0aWMgcmV2aWV3IGFuZCBtZXRhLWFuYWx5c2lzPC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBhZ2VzPjkwMi05MTA8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48bnVtYmVyPjExPC9udW1i

ZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFudGljb2FndWxhdGlvbjwva2V5d29yZD48a2V5d29yZD5I

b21lIHRyZWF0bWVudDwva2V5d29yZD48a2V5d29yZD5Nb3J0YWxpdHk8L2tleXdvcmQ+PGtleXdv

cmQ+UHVsbW9uYXJ5IGVtYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlJpZ2h0IHZlbnRyaWN1bGFy

IGR5c2Z1bmN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgc3RyYXRpZmljYXRpb248L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1h

ciAxNDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjItOTY0NSAoRWxlY3Ryb25p

YykmI3hEOzAxOTUtNjY4WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MzA1OTA1MzE8

L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmku

bmxtLm5paC5nb3YvcHVibWVkLzMwNTkwNTMxPC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3BtYy9hcnRpY2xlcy9QTUM2NDE2NTMzL3BkZi9laHk4NzMucGRmPC91cmw+PC9y

ZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzY0MTY1MzM8L2N1c3RvbTI+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVhcnRqL2VoeTg3MzwvZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJjbzwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MDk2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

NDI8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDk2PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5MzY2NjkiPjQwOTY8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJhcmNvLCBTLjwvYXV0aG9yPjxhdXRob3I+

TWFobW91ZHBvdXIsIFMuIEguPC9hdXRob3I+PGF1dGhvcj5QbGFucXVldHRlLCBCLjwvYXV0aG9y

PjxhdXRob3I+U2FuY2hleiwgTy48L2F1dGhvcj48YXV0aG9yPktvbnN0YW50aW5pZGVzLCBTLiBW

LjwvYXV0aG9yPjxhdXRob3I+TWV5ZXIsIEcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+Q2VudGVyIGZvciBUaHJvbWJvc2lzIGFuZCBIYWVtb3N0YXNpcyAo

Q1RIKSwgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRyZSBvZiB0aGUgSm9oYW5uZXMgR3V0ZW5iZXJn

IFVuaXZlcnNpdHksIExhbmdlbmJlY2tzdHJhc3NlIDEsIE1haW56LCBHZXJtYW55LiYjeEQ7RGVw

YXJ0bWVudCBvZiBCaW9tZXRyeSBhbmQgQmlvaW5mb3JtYXRpY3MsIEluc3RpdHV0ZSBmb3IgTWVk

aWNhbCBCaW9zdGF0aXN0aWNzLCBFcGlkZW1pb2xvZ3ksIGFuZCBJbmZvcm1hdGljcyAoSU1CRUkp

LCBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudHJlIG9mIHRoZSBKb2hhbm5lcyBHdXRlbmJlcmcgVW5p

dmVyc2l0eSwgT2JlcmUgWmFobGJhY2hlciBTdHJhc3NlIDY5LCBNYWlueiwgR2VybWFueS4mI3hE

O0YtQ1JJTiBJTk5PVlRFLCBIb3BpdGFsIE5vcmQsIENIVSBTYWludCBFdGllbm5lLCBBdmVudWUg

QWxiZXJ0IFJhaW1vbmQsIFNhaW50IFByaWVzdCBlbiBKYXJleiAoU2FpbnQgRXRpZW5uZSksIEZy

YW5jZS4mI3hEO1NlcnZpY2UgZGUgUG5ldW1vbG9naWUgZXQgZGUgU29pbnMgSW50ZW5zaWZzLCBI

b3BpdGFsIEV1cm9wZWVuIEdlb3JnZXMgUG9tcGlkb3UsIEFQLUhQLCBVbml2ZXJzaXRlIFBhcmlz

IERlc2NhcnRlcywgU29yYm9ubmUgUGFyaXMgQ2l0ZSwgSU5TRVJNIFVNUiBTIDExNDAsIDIwIHJ1

ZSBMZWJsYW5jLCBQYXJpcywgRnJhbmNlLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBE

ZW1vY3JpdHVzIFVuaXZlcnNpdHkgb2YgVGhyYWNlLCBVbml2ZXJzaXR5IEdlbmVyYWwgSG9zcGl0

YWwsIEFsZXhhbmRyb3Vwb2xpcywgR3JlZWNlLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PlByb2dub3N0aWMgdmFsdWUgb2YgcmlnaHQgdmVudHJpY3VsYXIgZHlzZnVuY3Rpb24gb3IgZWxl

dmF0ZWQgY2FyZGlhYyBiaW9tYXJrZXJzIGluIHBhdGllbnRzIHdpdGggbG93LXJpc2sgcHVsbW9u

YXJ5IGVtYm9saXNtOiBhIHN5c3RlbWF0aWMgcmV2aWV3IGFuZCBtZXRhLWFuYWx5c2lzPC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBIZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBhZ2VzPjkwMi05MTA8L3BhZ2VzPjx2b2x1bWU+NDA8L3ZvbHVtZT48bnVtYmVyPjExPC9udW1i

ZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFudGljb2FndWxhdGlvbjwva2V5d29yZD48a2V5d29yZD5I

b21lIHRyZWF0bWVudDwva2V5d29yZD48a2V5d29yZD5Nb3J0YWxpdHk8L2tleXdvcmQ+PGtleXdv

cmQ+UHVsbW9uYXJ5IGVtYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlJpZ2h0IHZlbnRyaWN1bGFy

IGR5c2Z1bmN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgc3RyYXRpZmljYXRpb248L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1h

ciAxNDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjItOTY0NSAoRWxlY3Ryb25p

YykmI3hEOzAxOTUtNjY4WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MzA1OTA1MzE8

L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmku

bmxtLm5paC5nb3YvcHVibWVkLzMwNTkwNTMxPC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3BtYy9hcnRpY2xlcy9QTUM2NDE2NTMzL3BkZi9laHk4NzMucGRmPC91cmw+PC9y

ZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzY0MTY1MzM8L2N1c3RvbTI+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVhcnRqL2VoeTg3MzwvZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA 42The diagnosis of PE during pregnancy is challenging with wide pregnancy-related and PE suspicion symptoms overlap. Overall PE prevalence is however low thus exposing patients to unnecessary imaging tests. The 2019 ESC PE guidelines propose a dedicated diagnostic algorithm for suspected PE in pregnancy using stratification tools based on clinical presentation, D-Dimer testing, and compression ultrasonography of lower extremities. The pregnancy adapted YEARS algorithm, which takes into account these three parameters, was recently shown to safely rule out PE across all trimesters of pregnancy avoiding a significant number of imaging tests.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIFBvbDwvQXV0aG9yPjxZZWFyPjIwMTk8L1ll

YXI+PFJlY051bT40MDk5PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNj

cmlwdCI+NDM8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDk5PC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6

YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5MzY4OTciPjQwOTk8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPnZhbiBkZXIgUG9sLCBMLiBNLjwv

YXV0aG9yPjxhdXRob3I+VHJvbWV1ciwgQy48L2F1dGhvcj48YXV0aG9yPkJpc3RlcnZlbHMsIEku

IE0uPC9hdXRob3I+PGF1dGhvcj5OaSBBaW5sZSwgRi48L2F1dGhvcj48YXV0aG9yPnZhbiBCZW1t

ZWwsIFQuPC9hdXRob3I+PGF1dGhvcj5CZXJ0b2xldHRpLCBMLjwvYXV0aG9yPjxhdXRob3I+Q291

dHVyYXVkLCBGLjwvYXV0aG9yPjxhdXRob3I+dmFuIERvb3JlbiwgWS4gUC4gQS48L2F1dGhvcj48

YXV0aG9yPkVsaWFzLCBBLjwvYXV0aG9yPjxhdXRob3I+RmFiZXIsIEwuIE0uPC9hdXRob3I+PGF1

dGhvcj5Ib2ZzdGVlLCBILiBNLiBBLjwvYXV0aG9yPjxhdXRob3I+dmFuIGRlciBIdWxsZSwgVC48

L2F1dGhvcj48YXV0aG9yPktydWlwLCBNamhhPC9hdXRob3I+PGF1dGhvcj5NYWlnbmFuLCBNLjwv

YXV0aG9yPjxhdXRob3I+TWFpcnVodSwgQS4gVC4gQS48L2F1dGhvcj48YXV0aG9yPk1pZGRlbGRv

cnAsIFMuPC9hdXRob3I+PGF1dGhvcj5OaWprZXV0ZXIsIE0uPC9hdXRob3I+PGF1dGhvcj5Sb3ks

IFAuIE0uPC9hdXRob3I+PGF1dGhvcj5TYW5jaGV6LCBPLjwvYXV0aG9yPjxhdXRob3I+U2NobWlk

dCwgSi48L2F1dGhvcj48YXV0aG9yPlRlbiBXb2xkZSwgTS48L2F1dGhvcj48YXV0aG9yPktsb2ss

IEYuIEEuPC9hdXRob3I+PGF1dGhvcj5IdWlzbWFuLCBNLiBWLjwvYXV0aG9yPjxhdXRob3I+QXJ0

ZW1pcyBTdHVkeSwgSW52ZXN0aWdhdG9yczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPkZyb20gdGhlIERlcGFydG1lbnQgb2YgVGhyb21ib3NpcyBhbmQgSGVt

b3N0YXNpcywgTGVpZGVuIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIExlaWRlbiAoTC5NLlAu

LCBULkguLCBGLkEuSy4sIE0uVi5ILiksIHRoZSBEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGlj

aW5lLCBIYWdhIFRlYWNoaW5nIEhvc3BpdGFsIChMLk0uUC4sIEEuVC5BLk0uKSwgYW5kIHRoZSBE

ZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBIYWFnbGFuZGVuIE1lZGljYWwgQ2VudGVy

IChILk0uQS5ILiksIHRoZSBEZXBhcnRtZW50IG9mIFZhc2N1bGFyIE1lZGljaW5lLCBBbXN0ZXJk

YW0gVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciwgVW5pdmVyc2l0eSBvZiBBbXN0ZXJkYW0sIEFt

c3RlcmRhbSBDYXJkaW92YXNjdWxhciBTY2llbmNlcywgQW1zdGVyZGFtIChJLk0uQi4sIFMuTS4p

LCB0aGUgRGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2luZSwgRmxldm8gSG9zcGl0YWwsIEFs

bWVyZSAoSS5NLkIuLCBNLlcuKSwgdGhlIERlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUs

IEdlbHJlIEhvc3BpdGFsLCBBcGVsZG9vcm4gKFQuQi4pLCB0aGUgRGVwYXJ0bWVudCBvZiBQdWxt

b25vbG9neSwgR3JvZW5lIEhhcnQgSG9zcGl0YWwsIEdvdWRhIChZLlAuQS5ELiksIHRoZSBEZXBh

cnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBSZWQgQ3Jvc3MgSG9zcGl0YWwsIEJldmVyd2lq

ayAoTC5NLkYuKSwgdGhlIERlcGFydG1lbnQgb2YgSGVtYXRvbG9neSwgRXJhc211cyBVbml2ZXJz

aXR5IE1lZGljYWwgQ2VudGVyLCBSb3R0ZXJkYW0gKE0uSi5ILkEuSy4pLCBhbmQgdGhlIERlcGFy

dG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUsIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIgVXRy

ZWNodCwgVXRyZWNodCAoTS5OLiksIGFsbCBvZiB3aGljaCBhcmUgcGFydCBvZiB0aGUgRHV0Y2gg

VGhyb21ib3NpcyBOZXR3b3JrIChEVE4pIC0gYWxsIGluIHRoZSBOZXRoZXJsYW5kczsgdGhlIERl

cGFydG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUgYW5kIENoZXN0IERpc2Vhc2VzLCBCcmVzdCBI

b3NwaXRhbCBDZW50ZXIsIEdyb3VwZSBkJmFwb3M7RXR1ZGUgZGUgVGhyb21ib3NlIGRlIEJyZXRh

Z25lIE9jY2lkZW50YWxlLCBVbml2ZXJzaXR5IG9mIEJyZXN0LCBFQSAzODc4LCBDSUMtSU5TRVJN

IDE0MTIsIFVuaXZlcnNpdHkgb2YgQnJlc3QsIEJyZXN0IChDLlQuLCBGLkMuKSwgU2VydmljZSBk

ZSBtZWRlY2luZSB2YXNjdWxhaXJlIGV0IHRoZXJhcGV1dGlxdWUsIENlbnRyZSBIb3NwaXRhbGll

ciBVbml2ZXJzaXRhaXJlIChDSFUpIFNhaW50IEV0aWVubmUsIElOU0VSTSBDSUMtMTQwOCwgSU5T

RVJNIFVuaXRlIDEwNTksIEVxdWlwZSBEeXNmb25jdGlvbiBWYXNjdWxhaXJlIGV0IEhlbW9zdGFz

ZSwgVW5pdmVyc2l0ZSBKZWFuLU1vbm5ldCwgU2FpbnQgRXRpZW5uZSAoTC5CLiksIHRoZSBEZXBh

cnRtZW50IG9mIFZhc2N1bGFyIE1lZGljaW5lLCBTYWludGUgTXVzc2UgSG9zcGl0YWwsIFRvdWxv

biAoQS5FLiksIHRoZSBFbWVyZ2VuY3kgRGVwYXJ0bWVudCwgQ0hVIEdyZW5vYmxlLUFscGVzLCBI

eXBveHktUGh5c2lvcGF0aG9sb2d5IGxhYm9yYXRvcnkgSFAyIElOU0VSTSAxMDQyLCBHcmVub2Js

ZSAoTS5NLiksIHRoZSBFbWVyZ2VuY3kgRGVwYXJ0bWVudCwgQ0hVIGQmYXBvcztBbmdlcnMsIFVG

UiBTYW50ZSwgVW5pdmVyc2l0ZSBkJmFwb3M7QW5nZXJzLCBJbnN0aXR1dCBNaXRvdmFzYywgVU1S

IENOUlMgNjAxNSBVTVIgSU5TRVJNIDEwODMsIEFuZ2VycyAoUC4tTS5SLiksIHRoZSBEZXBhcnRt

ZW50IG9mIFB1bG1vbmFyeSBEaXNlYXNlIGFuZCBJbnRlbnNpdmUgQ2FyZSBVbml0LCBIb3BpdGFs

IEV1cm9wZWVuIEdlb3JnZXMgUG9tcGlkb3UsIEFzc2lzdGFuY2UgUHVibGlxdWUtSG9waXRhdXgg

ZGUgUGFyaXMsIFVuaXZlcnNpdGUgUGFyaXMgRGVzY2FydGVzLCBGYWN1bHRlIGRlIE1lZGVjaW5l

LCBVbml2ZXJzaXRlIFNvcmJvbm5lIFBhcmlzIENpdGUsIElOU0VSTSBVTVIgUyAxMTQwLCBQYXJp

cyAoTy5TLiksIGFuZCB0aGUgRW1lcmdlbmN5IERlcGFydG1lbnQsIENIVSBkZSBDbGVybW9udC1G

ZXJyYW5kLCBDbGVybW9udC1GZXJyYW5kIChKLlMuKSwgYWxsIG9mIHdoaWNoIGFyZSBwYXJ0IG9m

IHRoZSBGcmVuY2ggQ2xpbmljYWwgUmVzZWFyY2ggSW5mcmFzdHJ1Y3R1cmUgTmV0d29yay1JbnZl

c3RpZ2F0aW9uIE5ldHdvcmsgb24gVmVub3VzIFRocm9tYm8tRW1ib2xpc20gKEYtQ1JJTiBJTk5P

VlRFIE5ldHdvcmssIFNhaW50IEV0aWVubmUpIC0gYWxsIGluIEZyYW5jZTsgYW5kIHRoZSBTY2hv

b2wgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgQ29sbGVnZSBEdWJsaW4sIGFuZCB0aGUgRGVwYXJ0

bWVudCBvZiBIYWVtYXRvbG9neSwgUm90dW5kYSBIb3NwaXRhbCBEdWJsaW4sIElOVmlURSBOZXR3

b3JrLCBEdWJsaW4gKEYuTi5BLikuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UHJlZ25h

bmN5LUFkYXB0ZWQgWUVBUlMgQWxnb3JpdGhtIGZvciBEaWFnbm9zaXMgb2YgU3VzcGVjdGVkIFB1

bG1vbmFyeSBFbWJvbGlzbTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OIEVuZ2wgSiBNZWQ8L3Nl

Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+MTEzOS0xMTQ5PC9wYWdlcz48dm9sdW1lPjM4

MDwvdm9sdW1lPjxudW1iZXI+MTI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWN1dGUgRGlz

ZWFzZTwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD4qQWxnb3JpdGht

czwva2V5d29yZD48a2V5d29yZD4qQ29tcHV0ZWQgVG9tb2dyYXBoeSBBbmdpb2dyYXBoeTwva2V5

d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+RmlicmluIEZpYnJpbm9nZW4g

RGVncmFkYXRpb24gUHJvZHVjdHMvKmFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPipIZW1vcHR5

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5QcmVnbmFuY3k8

L2tleXdvcmQ+PGtleXdvcmQ+UHJlZ25hbmN5IENvbXBsaWNhdGlvbnMsIENhcmRpb3Zhc2N1bGFy

LypkaWFnbm9zaXMvZGlhZ25vc3RpYyBpbWFnaW5nPC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0

aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+UHVsbW9uYXJ5IEVtYm9saXNtLypkaWFnbm9z

aXMvZGlhZ25vc3RpYyBpbWFnaW5nPC9rZXl3b3JkPjxrZXl3b3JkPipWZW5vdXMgVGhyb21ib2Vt

Ym9saXNtL2RpYWdub3Npczwva2V5d29yZD48a2V5d29yZD5WZW5vdXMgVGhyb21ib3Npcy9kaWFn

bm9zaXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHViLWRh

dGVzPjxkYXRlPk1hciAyMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMtNDQw

NiAoRWxlY3Ryb25pYykmI3hEOzAwMjgtNDc5MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MzA4OTM1MzQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBz

Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMwODkzNTM0PC91cmw+PHVybD5odHRwczov

L3d3dy5uZWptLm9yZy9kb2kvcGRmLzEwLjEwNTYvTkVKTW9hMTgxMzg2NT9hcnRpY2xlVG9vbHM9

dHJ1ZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTA1Ni9ORUpNb2ExODEzODY1PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48

L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIFBvbDwvQXV0aG9yPjxZZWFyPjIwMTk8L1ll

YXI+PFJlY051bT40MDk5PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNj

cmlwdCI+NDM8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDk5PC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6

YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5MzY4OTciPjQwOTk8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPnZhbiBkZXIgUG9sLCBMLiBNLjwv

YXV0aG9yPjxhdXRob3I+VHJvbWV1ciwgQy48L2F1dGhvcj48YXV0aG9yPkJpc3RlcnZlbHMsIEku

IE0uPC9hdXRob3I+PGF1dGhvcj5OaSBBaW5sZSwgRi48L2F1dGhvcj48YXV0aG9yPnZhbiBCZW1t

ZWwsIFQuPC9hdXRob3I+PGF1dGhvcj5CZXJ0b2xldHRpLCBMLjwvYXV0aG9yPjxhdXRob3I+Q291

dHVyYXVkLCBGLjwvYXV0aG9yPjxhdXRob3I+dmFuIERvb3JlbiwgWS4gUC4gQS48L2F1dGhvcj48

YXV0aG9yPkVsaWFzLCBBLjwvYXV0aG9yPjxhdXRob3I+RmFiZXIsIEwuIE0uPC9hdXRob3I+PGF1

dGhvcj5Ib2ZzdGVlLCBILiBNLiBBLjwvYXV0aG9yPjxhdXRob3I+dmFuIGRlciBIdWxsZSwgVC48

L2F1dGhvcj48YXV0aG9yPktydWlwLCBNamhhPC9hdXRob3I+PGF1dGhvcj5NYWlnbmFuLCBNLjwv

YXV0aG9yPjxhdXRob3I+TWFpcnVodSwgQS4gVC4gQS48L2F1dGhvcj48YXV0aG9yPk1pZGRlbGRv

cnAsIFMuPC9hdXRob3I+PGF1dGhvcj5OaWprZXV0ZXIsIE0uPC9hdXRob3I+PGF1dGhvcj5Sb3ks

IFAuIE0uPC9hdXRob3I+PGF1dGhvcj5TYW5jaGV6LCBPLjwvYXV0aG9yPjxhdXRob3I+U2NobWlk

dCwgSi48L2F1dGhvcj48YXV0aG9yPlRlbiBXb2xkZSwgTS48L2F1dGhvcj48YXV0aG9yPktsb2ss

IEYuIEEuPC9hdXRob3I+PGF1dGhvcj5IdWlzbWFuLCBNLiBWLjwvYXV0aG9yPjxhdXRob3I+QXJ0

ZW1pcyBTdHVkeSwgSW52ZXN0aWdhdG9yczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPkZyb20gdGhlIERlcGFydG1lbnQgb2YgVGhyb21ib3NpcyBhbmQgSGVt

b3N0YXNpcywgTGVpZGVuIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIExlaWRlbiAoTC5NLlAu

LCBULkguLCBGLkEuSy4sIE0uVi5ILiksIHRoZSBEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGlj

aW5lLCBIYWdhIFRlYWNoaW5nIEhvc3BpdGFsIChMLk0uUC4sIEEuVC5BLk0uKSwgYW5kIHRoZSBE

ZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBIYWFnbGFuZGVuIE1lZGljYWwgQ2VudGVy

IChILk0uQS5ILiksIHRoZSBEZXBhcnRtZW50IG9mIFZhc2N1bGFyIE1lZGljaW5lLCBBbXN0ZXJk

YW0gVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciwgVW5pdmVyc2l0eSBvZiBBbXN0ZXJkYW0sIEFt

c3RlcmRhbSBDYXJkaW92YXNjdWxhciBTY2llbmNlcywgQW1zdGVyZGFtIChJLk0uQi4sIFMuTS4p

LCB0aGUgRGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2luZSwgRmxldm8gSG9zcGl0YWwsIEFs

bWVyZSAoSS5NLkIuLCBNLlcuKSwgdGhlIERlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUs

IEdlbHJlIEhvc3BpdGFsLCBBcGVsZG9vcm4gKFQuQi4pLCB0aGUgRGVwYXJ0bWVudCBvZiBQdWxt

b25vbG9neSwgR3JvZW5lIEhhcnQgSG9zcGl0YWwsIEdvdWRhIChZLlAuQS5ELiksIHRoZSBEZXBh

cnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBSZWQgQ3Jvc3MgSG9zcGl0YWwsIEJldmVyd2lq

ayAoTC5NLkYuKSwgdGhlIERlcGFydG1lbnQgb2YgSGVtYXRvbG9neSwgRXJhc211cyBVbml2ZXJz

aXR5IE1lZGljYWwgQ2VudGVyLCBSb3R0ZXJkYW0gKE0uSi5ILkEuSy4pLCBhbmQgdGhlIERlcGFy

dG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUsIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIgVXRy

ZWNodCwgVXRyZWNodCAoTS5OLiksIGFsbCBvZiB3aGljaCBhcmUgcGFydCBvZiB0aGUgRHV0Y2gg

VGhyb21ib3NpcyBOZXR3b3JrIChEVE4pIC0gYWxsIGluIHRoZSBOZXRoZXJsYW5kczsgdGhlIERl

cGFydG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUgYW5kIENoZXN0IERpc2Vhc2VzLCBCcmVzdCBI

b3NwaXRhbCBDZW50ZXIsIEdyb3VwZSBkJmFwb3M7RXR1ZGUgZGUgVGhyb21ib3NlIGRlIEJyZXRh

Z25lIE9jY2lkZW50YWxlLCBVbml2ZXJzaXR5IG9mIEJyZXN0LCBFQSAzODc4LCBDSUMtSU5TRVJN

IDE0MTIsIFVuaXZlcnNpdHkgb2YgQnJlc3QsIEJyZXN0IChDLlQuLCBGLkMuKSwgU2VydmljZSBk

ZSBtZWRlY2luZSB2YXNjdWxhaXJlIGV0IHRoZXJhcGV1dGlxdWUsIENlbnRyZSBIb3NwaXRhbGll

ciBVbml2ZXJzaXRhaXJlIChDSFUpIFNhaW50IEV0aWVubmUsIElOU0VSTSBDSUMtMTQwOCwgSU5T

RVJNIFVuaXRlIDEwNTksIEVxdWlwZSBEeXNmb25jdGlvbiBWYXNjdWxhaXJlIGV0IEhlbW9zdGFz

ZSwgVW5pdmVyc2l0ZSBKZWFuLU1vbm5ldCwgU2FpbnQgRXRpZW5uZSAoTC5CLiksIHRoZSBEZXBh

cnRtZW50IG9mIFZhc2N1bGFyIE1lZGljaW5lLCBTYWludGUgTXVzc2UgSG9zcGl0YWwsIFRvdWxv

biAoQS5FLiksIHRoZSBFbWVyZ2VuY3kgRGVwYXJ0bWVudCwgQ0hVIEdyZW5vYmxlLUFscGVzLCBI

eXBveHktUGh5c2lvcGF0aG9sb2d5IGxhYm9yYXRvcnkgSFAyIElOU0VSTSAxMDQyLCBHcmVub2Js

ZSAoTS5NLiksIHRoZSBFbWVyZ2VuY3kgRGVwYXJ0bWVudCwgQ0hVIGQmYXBvcztBbmdlcnMsIFVG

UiBTYW50ZSwgVW5pdmVyc2l0ZSBkJmFwb3M7QW5nZXJzLCBJbnN0aXR1dCBNaXRvdmFzYywgVU1S

IENOUlMgNjAxNSBVTVIgSU5TRVJNIDEwODMsIEFuZ2VycyAoUC4tTS5SLiksIHRoZSBEZXBhcnRt

ZW50IG9mIFB1bG1vbmFyeSBEaXNlYXNlIGFuZCBJbnRlbnNpdmUgQ2FyZSBVbml0LCBIb3BpdGFs

IEV1cm9wZWVuIEdlb3JnZXMgUG9tcGlkb3UsIEFzc2lzdGFuY2UgUHVibGlxdWUtSG9waXRhdXgg

ZGUgUGFyaXMsIFVuaXZlcnNpdGUgUGFyaXMgRGVzY2FydGVzLCBGYWN1bHRlIGRlIE1lZGVjaW5l

LCBVbml2ZXJzaXRlIFNvcmJvbm5lIFBhcmlzIENpdGUsIElOU0VSTSBVTVIgUyAxMTQwLCBQYXJp

cyAoTy5TLiksIGFuZCB0aGUgRW1lcmdlbmN5IERlcGFydG1lbnQsIENIVSBkZSBDbGVybW9udC1G

ZXJyYW5kLCBDbGVybW9udC1GZXJyYW5kIChKLlMuKSwgYWxsIG9mIHdoaWNoIGFyZSBwYXJ0IG9m

IHRoZSBGcmVuY2ggQ2xpbmljYWwgUmVzZWFyY2ggSW5mcmFzdHJ1Y3R1cmUgTmV0d29yay1JbnZl

c3RpZ2F0aW9uIE5ldHdvcmsgb24gVmVub3VzIFRocm9tYm8tRW1ib2xpc20gKEYtQ1JJTiBJTk5P

VlRFIE5ldHdvcmssIFNhaW50IEV0aWVubmUpIC0gYWxsIGluIEZyYW5jZTsgYW5kIHRoZSBTY2hv

b2wgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgQ29sbGVnZSBEdWJsaW4sIGFuZCB0aGUgRGVwYXJ0

bWVudCBvZiBIYWVtYXRvbG9neSwgUm90dW5kYSBIb3NwaXRhbCBEdWJsaW4sIElOVmlURSBOZXR3

b3JrLCBEdWJsaW4gKEYuTi5BLikuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UHJlZ25h

bmN5LUFkYXB0ZWQgWUVBUlMgQWxnb3JpdGhtIGZvciBEaWFnbm9zaXMgb2YgU3VzcGVjdGVkIFB1

bG1vbmFyeSBFbWJvbGlzbTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OIEVuZ2wgSiBNZWQ8L3Nl

Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGFnZXM+MTEzOS0xMTQ5PC9wYWdlcz48dm9sdW1lPjM4

MDwvdm9sdW1lPjxudW1iZXI+MTI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWN1dGUgRGlz

ZWFzZTwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD4qQWxnb3JpdGht

czwva2V5d29yZD48a2V5d29yZD4qQ29tcHV0ZWQgVG9tb2dyYXBoeSBBbmdpb2dyYXBoeTwva2V5

d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+RmlicmluIEZpYnJpbm9nZW4g

RGVncmFkYXRpb24gUHJvZHVjdHMvKmFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPipIZW1vcHR5

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5QcmVnbmFuY3k8

L2tleXdvcmQ+PGtleXdvcmQ+UHJlZ25hbmN5IENvbXBsaWNhdGlvbnMsIENhcmRpb3Zhc2N1bGFy

LypkaWFnbm9zaXMvZGlhZ25vc3RpYyBpbWFnaW5nPC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0

aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+UHVsbW9uYXJ5IEVtYm9saXNtLypkaWFnbm9z

aXMvZGlhZ25vc3RpYyBpbWFnaW5nPC9rZXl3b3JkPjxrZXl3b3JkPipWZW5vdXMgVGhyb21ib2Vt

Ym9saXNtL2RpYWdub3Npczwva2V5d29yZD48a2V5d29yZD5WZW5vdXMgVGhyb21ib3Npcy9kaWFn

bm9zaXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHViLWRh

dGVzPjxkYXRlPk1hciAyMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMtNDQw

NiAoRWxlY3Ryb25pYykmI3hEOzAwMjgtNDc5MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MzA4OTM1MzQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBz

Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMwODkzNTM0PC91cmw+PHVybD5odHRwczov

L3d3dy5uZWptLm9yZy9kb2kvcGRmLzEwLjEwNTYvTkVKTW9hMTgxMzg2NT9hcnRpY2xlVG9vbHM9

dHJ1ZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTA1Ni9ORUpNb2ExODEzODY1PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48

L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA 43 Management of vein thrombosis at unusual sites is challenging in practice. Whether patients with isolated distal DVT (IDDVT) should be systematically treated with anticoagulation is still questioned. It is suggested to stratify patients with IDDVT in high- and low-risk of recurrence.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYWxlcmlvPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjQxMDA8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij40NDwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQxMDA8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2Vz

MnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTkzNjk5NiI+NDEwMDwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VmFsZXJpbywgTC48L2F1dGhvcj48YXV0

aG9yPkFtYmFnbGlvLCBDLjwvYXV0aG9yPjxhdXRob3I+QmFyb25lLCBNLjwvYXV0aG9yPjxhdXRo

b3I+Q2lvbGEsIE0uPC9hdXRob3I+PGF1dGhvcj5Lb25zdGFudGluaWRlcywgUy4gVi48L2F1dGhv

cj48YXV0aG9yPk1haG1vdWRwb3VyLCBTLiBILjwvYXV0aG9yPjxhdXRob3I+UGljY2hpLCBDLjwv

YXV0aG9yPjxhdXRob3I+UGllcmVzY2EsIEMuPC9hdXRob3I+PGF1dGhvcj5UcmluY2hlcm8sIEEu

PC9hdXRob3I+PGF1dGhvcj5CYXJjbywgUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5DZW50ZXIgZm9yIFRocm9tYm9zaXMgYW5kIEhlbW9zdGFzaXMsIFVu

aXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIgb2YgdGhlIEpvaGFubmVzIEd1dGVuYmVyZyBVbml2ZXJz

aXR5LU1haW56LCBNYWlueiwgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVk

aWNpbmUsIEZvbmRhemlvbmUgSVJDQ1MgUG9saWNsaW5pY28gJnF1b3Q7U2FuIE1hdHRlbywmcXVv

dDsgUGF2aWEsIEl0YWx5LiYjeEQ7VGhyb21ib2VtYm9saWMgRGlzZWFzZSBVbml0LCBJc3RpdHV0

aSBDbGluaWNpIFNjaWVudGlmaWNpIFNwYSBTQiBJUkNDUyBNYXVnZXJpLCBQYXZpYSwgSXRhbHku

JiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIERlbW9jcml0dXMgVW5pdmVyc2l0eSBvZiBU

aHJhY2UsIEFsZXhhbmRyb3Vwb2xpcywgR3JlZWNlLiYjeEQ7RGVwYXJ0bWVudCBvZiBCaW9tZXRy

eSBhbmQgQmlvaW5mb3JtYXRpY3MsIEluc3RpdHV0ZSBmb3IgTWVkaWNhbCBCaW9zdGF0aXN0aWNz

LCBFcGlkZW1pb2xvZ3ksIGFuZCBJbmZvcm1hdGljcyAoSU1CRUkpLCBVbml2ZXJzaXR5IE1lZGlj

YWwgQ2VudGVyIG9mIHRoZSBKb2hhbm5lcyBHdXRlbmJlcmcgVW5pdmVyc2l0eSwgTWFpbnosIEdl

cm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBQcmVzaWRpbyBPc3Bl

ZGFsaWVybyAmcXVvdDtNYWNlZG9uaW8gTWVsbG9uaSZxdW90OyBBU1NUIEZCRiAmcXVvdDtTYWNj

bywmcXVvdDsgTWlsYW5vLCBJdGFseS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5SZWN1

cnJlbmNlIFJpc2sgYWZ0ZXIgRmlyc3QgU3ltcHRvbWF0aWMgRGlzdGFsIHZlcnN1cyBQcm94aW1h

bCBEZWVwIFZlaW4gVGhyb21ib3NpcyBBY2NvcmRpbmcgdG8gQmFzZWxpbmUgUmlzayBGYWN0b3Jz

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlRIIE9wZW48L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGFnZXM+ZTU4LWU2MzwvcGFnZXM+PHZvbHVtZT4zPC92b2x1bWU+PG51bWJlcj4xPC9udW1i

ZXI+PGtleXdvcmRzPjxrZXl3b3JkPmVwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5wcm9n

bm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+cHVsbW9uYXJ5IGVtYm9saXNtPC9rZXl3b3JkPjxrZXl3

b3JkPnZlbm91cyB0aHJvbWJvZW1ib2xpc208L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHll

YXI+MjAxOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbjwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjI1MTItOTQ2NSAoRWxlY3Ryb25pYykmI3hEOzI1MTItOTQ2NSAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MzEyNDk5ODM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMxMjQ5OTgz

PC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3BtYy9hcnRpY2xlcy9QTUM2

NTI0OTA5L3BkZi8xMC0xMDU1LXMtMDAzOS0xNjgzMzc0LnBkZjwvdXJsPjwvcmVsYXRlZC11cmxz

PjwvdXJscz48Y3VzdG9tMj5QTUM2NTI0OTA5PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNl

LW51bT4xMC4xMDU1L3MtMDAzOS0xNjgzMzc0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3Jl

Y29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYWxlcmlvPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjQxMDA8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij40NDwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQxMDA8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyZWFwMDJmZmp4cHphc2Vz

MnI3NTBhZGdmZmR2ZjV4ZWZ2cHAiIHRpbWVzdGFtcD0iMTU2OTkzNjk5NiI+NDEwMDwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VmFsZXJpbywgTC48L2F1dGhvcj48YXV0

aG9yPkFtYmFnbGlvLCBDLjwvYXV0aG9yPjxhdXRob3I+QmFyb25lLCBNLjwvYXV0aG9yPjxhdXRo

b3I+Q2lvbGEsIE0uPC9hdXRob3I+PGF1dGhvcj5Lb25zdGFudGluaWRlcywgUy4gVi48L2F1dGhv

cj48YXV0aG9yPk1haG1vdWRwb3VyLCBTLiBILjwvYXV0aG9yPjxhdXRob3I+UGljY2hpLCBDLjwv

YXV0aG9yPjxhdXRob3I+UGllcmVzY2EsIEMuPC9hdXRob3I+PGF1dGhvcj5UcmluY2hlcm8sIEEu

PC9hdXRob3I+PGF1dGhvcj5CYXJjbywgUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5DZW50ZXIgZm9yIFRocm9tYm9zaXMgYW5kIEhlbW9zdGFzaXMsIFVu

aXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIgb2YgdGhlIEpvaGFubmVzIEd1dGVuYmVyZyBVbml2ZXJz

aXR5LU1haW56LCBNYWlueiwgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVk

aWNpbmUsIEZvbmRhemlvbmUgSVJDQ1MgUG9saWNsaW5pY28gJnF1b3Q7U2FuIE1hdHRlbywmcXVv

dDsgUGF2aWEsIEl0YWx5LiYjeEQ7VGhyb21ib2VtYm9saWMgRGlzZWFzZSBVbml0LCBJc3RpdHV0

aSBDbGluaWNpIFNjaWVudGlmaWNpIFNwYSBTQiBJUkNDUyBNYXVnZXJpLCBQYXZpYSwgSXRhbHku

JiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIERlbW9jcml0dXMgVW5pdmVyc2l0eSBvZiBU

aHJhY2UsIEFsZXhhbmRyb3Vwb2xpcywgR3JlZWNlLiYjeEQ7RGVwYXJ0bWVudCBvZiBCaW9tZXRy

eSBhbmQgQmlvaW5mb3JtYXRpY3MsIEluc3RpdHV0ZSBmb3IgTWVkaWNhbCBCaW9zdGF0aXN0aWNz

LCBFcGlkZW1pb2xvZ3ksIGFuZCBJbmZvcm1hdGljcyAoSU1CRUkpLCBVbml2ZXJzaXR5IE1lZGlj

YWwgQ2VudGVyIG9mIHRoZSBKb2hhbm5lcyBHdXRlbmJlcmcgVW5pdmVyc2l0eSwgTWFpbnosIEdl

cm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBQcmVzaWRpbyBPc3Bl

ZGFsaWVybyAmcXVvdDtNYWNlZG9uaW8gTWVsbG9uaSZxdW90OyBBU1NUIEZCRiAmcXVvdDtTYWNj

bywmcXVvdDsgTWlsYW5vLCBJdGFseS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5SZWN1

cnJlbmNlIFJpc2sgYWZ0ZXIgRmlyc3QgU3ltcHRvbWF0aWMgRGlzdGFsIHZlcnN1cyBQcm94aW1h

bCBEZWVwIFZlaW4gVGhyb21ib3NpcyBBY2NvcmRpbmcgdG8gQmFzZWxpbmUgUmlzayBGYWN0b3Jz

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlRIIE9wZW48L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGFnZXM+ZTU4LWU2MzwvcGFnZXM+PHZvbHVtZT4zPC92b2x1bWU+PG51bWJlcj4xPC9udW1i

ZXI+PGtleXdvcmRzPjxrZXl3b3JkPmVwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5wcm9n

bm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+cHVsbW9uYXJ5IGVtYm9saXNtPC9rZXl3b3JkPjxrZXl3

b3JkPnZlbm91cyB0aHJvbWJvZW1ib2xpc208L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHll

YXI+MjAxOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbjwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjI1MTItOTQ2NSAoRWxlY3Ryb25pYykmI3hEOzI1MTItOTQ2NSAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MzEyNDk5ODM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMxMjQ5OTgz

PC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3BtYy9hcnRpY2xlcy9QTUM2

NTI0OTA5L3BkZi8xMC0xMDU1LXMtMDAzOS0xNjgzMzc0LnBkZjwvdXJsPjwvcmVsYXRlZC11cmxz

PjwvdXJscz48Y3VzdG9tMj5QTUM2NTI0OTA5PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNl

LW51bT4xMC4xMDU1L3MtMDAzOS0xNjgzMzc0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3Jl

Y29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 44 Those at high risk should be anticoagulated as for proximal DVT.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXp6b2xhaTwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+

PFJlY051bT40MTA0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+NDU8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA0PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNl

czJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc0MjYiPjQxMDQ8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1henpvbGFpLCBMLjwvYXV0aG9yPjxh

dXRob3I+QWJveWFucywgVi48L2F1dGhvcj48YXV0aG9yPkFnZW5vLCBXLjwvYXV0aG9yPjxhdXRo

b3I+QWduZWxsaSwgRy48L2F1dGhvcj48YXV0aG9yPkFsYXRyaSwgQS48L2F1dGhvcj48YXV0aG9y

PkJhdWVyc2FjaHMsIFIuPC9hdXRob3I+PGF1dGhvcj5CcmVrZWxtYW5zLCBNLiBQLiBBLjwvYXV0

aG9yPjxhdXRob3I+QnVsbGVyLCBILiBSLjwvYXV0aG9yPjxhdXRob3I+RWxpYXMsIEEuPC9hdXRo

b3I+PGF1dGhvcj5GYXJnZSwgRC48L2F1dGhvcj48YXV0aG9yPktvbnN0YW50aW5pZGVzLCBTLjwv

YXV0aG9yPjxhdXRob3I+UGFsYXJldGksIEcuPC9hdXRob3I+PGF1dGhvcj5QcmFuZG9uaSwgUC48

L2F1dGhvcj48YXV0aG9yPlJpZ2hpbmksIE0uPC9hdXRob3I+PGF1dGhvcj5Ub3JiaWNraSwgQS48

L2F1dGhvcj48YXV0aG9yPlZsYWNob3BvdWxvcywgQy48L2F1dGhvcj48YXV0aG9yPkJyb2RtYW5u

LCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlz

aW9uIG9mIEFuZ2lvbG9neSwgSGVhcnQgYW5kIFZlc3NlbCBEZXBhcnRtZW50LCBMYXVzYW5uZSBV

bml2ZXJzaXR5IEhvc3BpdGFsLCBDaCBkdSBNb250LVBhaXNpYmxlIDE4LCBMYXVzYW5uZSwgU3dp

dHplcmxhbmQuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIER1cHV5dHJlbiBVbml2ZXJz

aXR5IEhvc3BpdGFsLCBhbmQsIEluc2VybSAxMDk4LCBUcm9waWNhbCBOZXVyb2VwaWRlbWlvbG9n

eSwgU2Nob29sIG9mIE1lZGljaW5lLCAyIGF2ZW51ZSBtYXJ0aW4gTHV0aGVyLUtpbmcsIExpbW9n

ZXMgY2VkZXgsIEZyYW5jZS4mI3hEO0RlcGFydG1lbnQgb2YgQ2xpbmljYWwgYW5kIEV4cGVyaW1l

bnRhbCBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBJbnN1YnJpYSwgVmlhIFJhdmFzaSAyLCBWYXJl

c2UsIEl0YWx5LiYjeEQ7SW50ZXJuYWwgYW5kIENhcmRpb3Zhc2N1bGFyIE1lZGljaW5lIC0gU3Ry

b2tlIFVuaXQsIFVuaXZlcnNpdHkgb2YgUGVydWdpYSwgUy4gQW5kcmVhIGRlbGxlIEZyYXR0ZSwg

UGVydWdpYSwgSXRhbHkuJiN4RDtEZXBhcnRtZW50IG9mIFZhc2N1bGFyIE1lZGljaW5lLCBLbGlu

aWt1bSBEYXJtc3RhZHQgR21iSCwgR3JhZmVuc3RyYXNzZSA5LCBEYXJtc3RhZHQsIEdlcm1hbnku

JiN4RDtDZW50ZXIgZm9yIFRocm9tYm9zaXMgYW5kIEhlbW9zdGFzaXMsIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIgTWFpbnosIExhbmdlbmJlY2tzdHIuIDEsIE1haW56LCBHZXJtYW55LiYjeEQ7

RGVwYXJ0bWVudCBvZiBWYXNjdWxhciBNZWRpY2luZSwgQWNhZGVtaWMgTWVkaWNhbCBDZW50ZXIs

IE1laWJlcmdkcmVlZiA5LCBBWiwgQW1zdGVyZGFtLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtDYXJk

aW9sb2d5IGFuZCBWYXNjdWxhciBNZWRpY2luZSwgVG91bG9uIEhvc3BpdGFsIENlbnRyZSwgNTQg

UnVlIEhlbnJpIFNhaW50ZS1DbGFpcmUgRGV2aWxsZSwgVG91bG9uLCBGcmFuY2UuJiN4RDtBc3Np

c3RhbmNlIFB1YmxpcXVlLUhvcGl0YXV4IGRlIFBhcmlzLCBTYWludC1Mb3VpcyBIb3NwaXRhbCwg

SW50ZXJuYWwgTWVkaWNpbmUgYW5kIFZhc2N1bGFyIERpc2Vhc2UgVW5pdCBhbmQgR3JvdXBlIEZy

YW5jb3Bob25lIG9uIFRocm9tYm9zaXMgYW5kIENhbmNlciwgUGFyaXMgNyBEaWRlcm90IFVuaXZl

cnNpdHksIFNvcmJvbm5lIFBhcmlzIENpdGUsIDEsIEF2ZW51ZSBDbGF1ZGUgVmVsbGVmYXV4LCBQ

YXJpcywgRnJhbmNlLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBEZW1vY3JpdHVzIFVu

aXZlcnNpdHkgb2YgVGhyYWNlLCBHcmVlY2UuJiN4RDtDYXJkaW92YXNjdWxhciBEaXNlYXNlcywg

VW5pdmVyc2l0eSBvZiBCb2xvZ25hLCBWaWEgQWxiZXJ0b25pIDE1LCBCb2xvZ25hLCBJdGFseS4m

I3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvdmFzY3VsYXIgU2NpZW5jZXMsIFZhc2N1bGFyIE1lZGlj

aW5lIFVuaXQsIFVuaXZlcnNpdHkgb2YgUGFkdWEsIFZpYSBOaWNvbG8gR2l1c3RpbmlhbmksIDIs

IFBhZHVhLCBJdGFseS4mI3hEO0RpdmlzaW9uIG9mIEFuZ2lvbG9neSBhbmQgSGVtb3N0YXNpcywg

RGVwYXJ0bWVudCBvZiBNZWRpY2FsIFNwZWNpYWx0aWVzLCBHZW5ldmEgVW5pdmVyc2l0eSBIb3Nw

aXRhbCwgUnVlIEdhYnJpZWxsZSBQZXJyZXQtR2VudGlsIDQsIEdlbmV2YSwgU3dpdHplcmxhbmQu

JiN4RDtEZXBhcnRtZW50IG9mIFB1bG1vbmFyeSBDaXJjdWxhdGlvbiBhbmQgVGhyb21ib2VtYm9s

aWMgRGlzZWFzZXMsIE1lZGljYWwgQ2VudGVyIGZvciBQb3N0Z3JhZHVhdGUgRWR1Y2F0aW9uLCB1

bCBQbG9ja2EgMjYsIFdhcnN6YXdhLCBPdHdvY2ssIFBvbGFuZC4mI3hEO0RlcGFydG1lbnQgb2Yg

Q2FyZGlvbG9neSwgQXRoZW5zIE1lZGljYWwgU2Nob29sLCBQcm9maXRpIGVsaWEgMjQsIEF0aGVu

cywgR3JlZWNlLiYjeEQ7RGl2aXNpb24gb2YgQW5naW9sb2d5LCBNZWRpY2FsIFVuaXZlcnNpdHkg

R3JheiwgR3JheiwgQXVzdHJpYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EaWFnbm9z

aXMgYW5kIG1hbmFnZW1lbnQgb2YgYWN1dGUgZGVlcCB2ZWluIHRocm9tYm9zaXM6IGEgam9pbnQg

Y29uc2Vuc3VzIGRvY3VtZW50IGZyb20gdGhlIEV1cm9wZWFuIFNvY2lldHkgb2YgQ2FyZGlvbG9n

eSB3b3JraW5nIGdyb3VwcyBvZiBhb3J0YSBhbmQgcGVyaXBoZXJhbCB2YXNjdWxhciBkaXNlYXNl

cyBhbmQgcHVsbW9uYXJ5IGNpcmN1bGF0aW9uIGFuZCByaWdodCB2ZW50cmljdWxhciBmdW5jdGlv

bjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwYWdlcz40MjA4LTQyMTg8L3BhZ2VzPjx2b2x1bWU+Mzk8L3ZvbHVtZT48bnVtYmVy

PjQ3PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWMg

MTQ8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMp

JiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI4MzI5MjYyPC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3B1Ym1lZC8yODMyOTI2MjwvdXJsPjx1cmw+aHR0cHM6Ly9hY2FkZW1pYy5vdXAu

Y29tL2V1cmhlYXJ0ai9hcnRpY2xlLWFic3RyYWN0LzM5LzQ3LzQyMDgvMzAwMjY0Nz9yZWRpcmVj

dGVkRnJvbT1mdWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh4MDAzPC9lbGVjdHJvbmljLXJlc291cmNl

LW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXp6b2xhaTwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+

PFJlY051bT40MTA0PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlw

dCI+NDU8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA0PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNl

czJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc0MjYiPjQxMDQ8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1henpvbGFpLCBMLjwvYXV0aG9yPjxh

dXRob3I+QWJveWFucywgVi48L2F1dGhvcj48YXV0aG9yPkFnZW5vLCBXLjwvYXV0aG9yPjxhdXRo

b3I+QWduZWxsaSwgRy48L2F1dGhvcj48YXV0aG9yPkFsYXRyaSwgQS48L2F1dGhvcj48YXV0aG9y

PkJhdWVyc2FjaHMsIFIuPC9hdXRob3I+PGF1dGhvcj5CcmVrZWxtYW5zLCBNLiBQLiBBLjwvYXV0

aG9yPjxhdXRob3I+QnVsbGVyLCBILiBSLjwvYXV0aG9yPjxhdXRob3I+RWxpYXMsIEEuPC9hdXRo

b3I+PGF1dGhvcj5GYXJnZSwgRC48L2F1dGhvcj48YXV0aG9yPktvbnN0YW50aW5pZGVzLCBTLjwv

YXV0aG9yPjxhdXRob3I+UGFsYXJldGksIEcuPC9hdXRob3I+PGF1dGhvcj5QcmFuZG9uaSwgUC48

L2F1dGhvcj48YXV0aG9yPlJpZ2hpbmksIE0uPC9hdXRob3I+PGF1dGhvcj5Ub3JiaWNraSwgQS48

L2F1dGhvcj48YXV0aG9yPlZsYWNob3BvdWxvcywgQy48L2F1dGhvcj48YXV0aG9yPkJyb2RtYW5u

LCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlz

aW9uIG9mIEFuZ2lvbG9neSwgSGVhcnQgYW5kIFZlc3NlbCBEZXBhcnRtZW50LCBMYXVzYW5uZSBV

bml2ZXJzaXR5IEhvc3BpdGFsLCBDaCBkdSBNb250LVBhaXNpYmxlIDE4LCBMYXVzYW5uZSwgU3dp

dHplcmxhbmQuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIER1cHV5dHJlbiBVbml2ZXJz

aXR5IEhvc3BpdGFsLCBhbmQsIEluc2VybSAxMDk4LCBUcm9waWNhbCBOZXVyb2VwaWRlbWlvbG9n

eSwgU2Nob29sIG9mIE1lZGljaW5lLCAyIGF2ZW51ZSBtYXJ0aW4gTHV0aGVyLUtpbmcsIExpbW9n

ZXMgY2VkZXgsIEZyYW5jZS4mI3hEO0RlcGFydG1lbnQgb2YgQ2xpbmljYWwgYW5kIEV4cGVyaW1l

bnRhbCBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBJbnN1YnJpYSwgVmlhIFJhdmFzaSAyLCBWYXJl

c2UsIEl0YWx5LiYjeEQ7SW50ZXJuYWwgYW5kIENhcmRpb3Zhc2N1bGFyIE1lZGljaW5lIC0gU3Ry

b2tlIFVuaXQsIFVuaXZlcnNpdHkgb2YgUGVydWdpYSwgUy4gQW5kcmVhIGRlbGxlIEZyYXR0ZSwg

UGVydWdpYSwgSXRhbHkuJiN4RDtEZXBhcnRtZW50IG9mIFZhc2N1bGFyIE1lZGljaW5lLCBLbGlu

aWt1bSBEYXJtc3RhZHQgR21iSCwgR3JhZmVuc3RyYXNzZSA5LCBEYXJtc3RhZHQsIEdlcm1hbnku

JiN4RDtDZW50ZXIgZm9yIFRocm9tYm9zaXMgYW5kIEhlbW9zdGFzaXMsIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIgTWFpbnosIExhbmdlbmJlY2tzdHIuIDEsIE1haW56LCBHZXJtYW55LiYjeEQ7

RGVwYXJ0bWVudCBvZiBWYXNjdWxhciBNZWRpY2luZSwgQWNhZGVtaWMgTWVkaWNhbCBDZW50ZXIs

IE1laWJlcmdkcmVlZiA5LCBBWiwgQW1zdGVyZGFtLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtDYXJk

aW9sb2d5IGFuZCBWYXNjdWxhciBNZWRpY2luZSwgVG91bG9uIEhvc3BpdGFsIENlbnRyZSwgNTQg

UnVlIEhlbnJpIFNhaW50ZS1DbGFpcmUgRGV2aWxsZSwgVG91bG9uLCBGcmFuY2UuJiN4RDtBc3Np

c3RhbmNlIFB1YmxpcXVlLUhvcGl0YXV4IGRlIFBhcmlzLCBTYWludC1Mb3VpcyBIb3NwaXRhbCwg

SW50ZXJuYWwgTWVkaWNpbmUgYW5kIFZhc2N1bGFyIERpc2Vhc2UgVW5pdCBhbmQgR3JvdXBlIEZy

YW5jb3Bob25lIG9uIFRocm9tYm9zaXMgYW5kIENhbmNlciwgUGFyaXMgNyBEaWRlcm90IFVuaXZl

cnNpdHksIFNvcmJvbm5lIFBhcmlzIENpdGUsIDEsIEF2ZW51ZSBDbGF1ZGUgVmVsbGVmYXV4LCBQ

YXJpcywgRnJhbmNlLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBEZW1vY3JpdHVzIFVu

aXZlcnNpdHkgb2YgVGhyYWNlLCBHcmVlY2UuJiN4RDtDYXJkaW92YXNjdWxhciBEaXNlYXNlcywg

VW5pdmVyc2l0eSBvZiBCb2xvZ25hLCBWaWEgQWxiZXJ0b25pIDE1LCBCb2xvZ25hLCBJdGFseS4m

I3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlvdmFzY3VsYXIgU2NpZW5jZXMsIFZhc2N1bGFyIE1lZGlj

aW5lIFVuaXQsIFVuaXZlcnNpdHkgb2YgUGFkdWEsIFZpYSBOaWNvbG8gR2l1c3RpbmlhbmksIDIs

IFBhZHVhLCBJdGFseS4mI3hEO0RpdmlzaW9uIG9mIEFuZ2lvbG9neSBhbmQgSGVtb3N0YXNpcywg

RGVwYXJ0bWVudCBvZiBNZWRpY2FsIFNwZWNpYWx0aWVzLCBHZW5ldmEgVW5pdmVyc2l0eSBIb3Nw

aXRhbCwgUnVlIEdhYnJpZWxsZSBQZXJyZXQtR2VudGlsIDQsIEdlbmV2YSwgU3dpdHplcmxhbmQu

JiN4RDtEZXBhcnRtZW50IG9mIFB1bG1vbmFyeSBDaXJjdWxhdGlvbiBhbmQgVGhyb21ib2VtYm9s

aWMgRGlzZWFzZXMsIE1lZGljYWwgQ2VudGVyIGZvciBQb3N0Z3JhZHVhdGUgRWR1Y2F0aW9uLCB1

bCBQbG9ja2EgMjYsIFdhcnN6YXdhLCBPdHdvY2ssIFBvbGFuZC4mI3hEO0RlcGFydG1lbnQgb2Yg

Q2FyZGlvbG9neSwgQXRoZW5zIE1lZGljYWwgU2Nob29sLCBQcm9maXRpIGVsaWEgMjQsIEF0aGVu

cywgR3JlZWNlLiYjeEQ7RGl2aXNpb24gb2YgQW5naW9sb2d5LCBNZWRpY2FsIFVuaXZlcnNpdHkg

R3JheiwgR3JheiwgQXVzdHJpYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EaWFnbm9z

aXMgYW5kIG1hbmFnZW1lbnQgb2YgYWN1dGUgZGVlcCB2ZWluIHRocm9tYm9zaXM6IGEgam9pbnQg

Y29uc2Vuc3VzIGRvY3VtZW50IGZyb20gdGhlIEV1cm9wZWFuIFNvY2lldHkgb2YgQ2FyZGlvbG9n

eSB3b3JraW5nIGdyb3VwcyBvZiBhb3J0YSBhbmQgcGVyaXBoZXJhbCB2YXNjdWxhciBkaXNlYXNl

cyBhbmQgcHVsbW9uYXJ5IGNpcmN1bGF0aW9uIGFuZCByaWdodCB2ZW50cmljdWxhciBmdW5jdGlv

bjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSGVhcnQgSjwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwYWdlcz40MjA4LTQyMTg8L3BhZ2VzPjx2b2x1bWU+Mzk8L3ZvbHVtZT48bnVtYmVy

PjQ3PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWMg

MTQ8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMp

JiN4RDswMTk1LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI4MzI5MjYyPC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3B1Ym1lZC8yODMyOTI2MjwvdXJsPjx1cmw+aHR0cHM6Ly9hY2FkZW1pYy5vdXAu

Y29tL2V1cmhlYXJ0ai9hcnRpY2xlLWFic3RyYWN0LzM5LzQ3LzQyMDgvMzAwMjY0Nz9yZWRpcmVj

dGVkRnJvbT1mdWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh4MDAzPC9lbGVjdHJvbmljLXJlc291cmNl

LW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA 45 With this regard, recent prospective registries suggested that patients with IDDVT may be treated with DOACs although data from clinical trials are still missing.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZ2VubzwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MTAxPC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

NDYsIDQ3PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDEwMTwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5OTM3MDk5Ij40MTAxPC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BZ2VubywgVy48L2F1dGhvcj48YXV0

aG9yPk1hbnRvdmFuaSwgTC4gRy48L2F1dGhvcj48YXV0aG9yPkhhYXMsIFMuPC9hdXRob3I+PGF1

dGhvcj5LcmV1dHosIFIuPC9hdXRob3I+PGF1dGhvcj5Nb25qZSwgRC48L2F1dGhvcj48YXV0aG9y

PlNjaG5laWRlciwgSi48L2F1dGhvcj48YXV0aG9yPkJ1Z2dlLCBKLiBQLjwvYXV0aG9yPjxhdXRo

b3I+R2ViZWwsIE0uPC9hdXRob3I+PGF1dGhvcj5UdXJwaWUsIEEuIEcuIEcuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2lu

ZSBhbmQgU3VyZ2VyeSwgVW5pdmVyc2l0eSBvZiBJbnN1YnJpYSwgVmFyZXNlLCBJdGFseS4mI3hE

O0NFU1AtQ2VudGVyIGZvciBQdWJsaWMgSGVhbHRoIFJlc2VhcmNoLCBVbml2ZXJzaXR5IG9mIE1p

bGFuby1CaWNvY2NhLCBNb256YSwgSXRhbHkuJiN4RDtGb3JtZXJseSBJbnN0aXR1dGUgZm9yIEV4

cGVyaW1lbnRhbCBPbmNvbG9neSBhbmQgVGhlcmFweSBSZXNlYXJjaCwgVGVjaG5pY2FsIFVuaXZl

cnNpdHkgb2YgTXVuaWNoLCBNdW5pY2gsIEdlcm1hbnkuJiN4RDtDaGFyaXRlLVVuaXZlcnNpdGF0

c21lZGl6aW4gQmVybGluLCBjb3Jwb3JhdGUgbWVtYmVyIG9mIEZyZWllIFVuaXZlcnNpdGF0IEJl

cmxpbiwgSHVtYm9sZHQtVW5pdmVyc2l0YXQgenUgQmVybGluLCBhbmQgQmVybGluIEluc3RpdHV0

ZSBvZiBIZWFsdGgsIEluc3RpdHV0ZSBvZiBDbGluaWNhbCBQaGFybWFjb2xvZ3kgYW5kIFRveGlj

b2xvZ3ksIEJlcmxpbiwgR2VybWFueS4mI3hEO0JheWVyIEFHLCBCZXJsaW4sIEdlcm1hbnkuJiN4

RDtCYXllciBBRywgV3VwcGVydGFsLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2lu

ZSwgSGFtaWx0b24gSGVhbHRoIFNjaWVuY2VzLCBIYW1pbHRvbiwgT250YXJpbywgQ2FuYWRhLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlBhdGllbnQgTWFuYWdlbWVudCBTdHJhdGVnaWVz

IGFuZCBMb25nLVRlcm0gT3V0Y29tZXMgaW4gSXNvbGF0ZWQgRGlzdGFsIERlZXAtVmVpbiBUaHJv

bWJvc2lzIHZlcnN1cyBQcm94aW1hbCBEZWVwLVZlaW4gVGhyb21ib3NpczogRmluZGluZ3MgZnJv

bSBYQUxJQTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5USCBPcGVuPC9zZWNvbmRhcnktdGl0bGU+

PC90aXRsZXM+PHBhZ2VzPmU4NS1lOTM8L3BhZ2VzPjx2b2x1bWU+Mzwvdm9sdW1lPjxudW1iZXI+

MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5kZWVwLXZlaW4gdGhyb21ib3Npczwva2V5d29y

ZD48a2V5d29yZD5yaXZhcm94YWJhbjwva2V5d29yZD48a2V5d29yZD5yb3V0aW5lIGNsaW5pY2Fs

IHByYWN0aWNlPC9rZXl3b3JkPjxrZXl3b3JkPnZlbm91cyB0aHJvbWJvZW1ib2xpc208L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkph

bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjI1MTItOTQ2NSAoRWxlY3Ryb25pYykm

I3hEOzI1MTItOTQ2NSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MzEyNDk5ODc8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzMxMjQ5OTg3PC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5u

aWguZ292L3BtYy9hcnRpY2xlcy9QTUM2NTI0OTEzL3BkZi8xMC0xMDU1LXMtMDAzOS0xNjgzOTY4

LnBkZjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM2NTI0OTEzPC9jdXN0

b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDU1L3MtMDAzOS0xNjgzOTY4PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5TY2hlbGxv

bmc8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNOdW0+NDEwMjwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+NDEwMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjJlYXAwMmZmanhwemFzZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIx

NTY5OTM3MTI5Ij40MTAyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5T

Y2hlbGxvbmcsIFMuIE0uPC9hdXRob3I+PGF1dGhvcj5Hb2xkaGFiZXIsIFMuIFouPC9hdXRob3I+

PGF1dGhvcj5XZWl0eiwgSi4gSS48L2F1dGhvcj48YXV0aG9yPkFnZW5vLCBXLjwvYXV0aG9yPjxh

dXRob3I+Qm91bmFtZWF1eCwgSC48L2F1dGhvcj48YXV0aG9yPlR1cnBpZSwgQS4gRy4gRy48L2F1

dGhvcj48YXV0aG9yPkFuZ2NoYWlzdWtzaXJpLCBQLjwvYXV0aG9yPjxhdXRob3I+SGFhcywgUy48

L2F1dGhvcj48YXV0aG9yPkdvdG8sIFMuPC9hdXRob3I+PGF1dGhvcj5aYWdoZG91biwgQS48L2F1

dGhvcj48YXV0aG9yPkZhcmphdCwgQS48L2F1dGhvcj48YXV0aG9yPk5pZWxzZW4sIEouIEQuPC9h

dXRob3I+PGF1dGhvcj5LYXlhbmksIEcuPC9hdXRob3I+PGF1dGhvcj5NYW50b3ZhbmksIEwuIEcu

PC9hdXRob3I+PGF1dGhvcj5QcmFuZG9uaSwgUC48L2F1dGhvcj48YXV0aG9yPktha2thciwgQS4g

Sy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NZWRpY2Fs

IERpdmlzaW9uIDIsIE11bmljaXBhbCBIb3NwaXRhbCBEcmVzZGVuLUZyaWVkcmljaHN0YWR0LCBE

cmVzZGVuLCBHZXJtYW55LiYjeEQ7SGFydmFyZCBNZWRpY2FsIFNjaG9vbCwgSGFydmFyZCBVbml2

ZXJzaXR5LCBCb3N0b24sIE1hc3NhY2h1c2V0dHMsIFVuaXRlZCBTdGF0ZXMuJiN4RDtUaHJvbWJv

c2lzIGFuZCBBdGhlcm9zY2xlcm9zaXMgUmVzZWFyY2ggSW5zdGl0dXRlLCBNY01hc3RlciBVbml2

ZXJzaXR5LCBIYW1pbHRvbiwgT250YXJpbywgQ2FuYWRhLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRp

Y2luZSBhbmQgU3VyZ2VyeSwgVW5pdmVyc2l0eSBvZiBJbnN1YnJpYSwgVmFyZXNlLCBJdGFseS4m

I3hEO0ZhY3VsdHkgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgSG9zcGl0YWxzIG9mIEdlbmV2YSwg

R2VuZXZhLCBTd2l0emVybGFuZC4mI3hEO01jTWFzdGVyIFVuaXZlcnNpdHksIEhhbWlsdG9uLCBP

bnRhcmlvLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBSYW1hdGhpYm9kaSBI

b3NwaXRhbCwgTWFoaWRvbCBVbml2ZXJzaXR5LCBCYW5na29rLCBUaGFpbGFuZC4mI3hEO0RlcGFy

dG1lbnQgb2YgTWVkaWNpbmUsIFRlY2huaWNhbCBVbml2ZXJzaXR5IG9mIE11bmljaCwgTXVuaWNo

LCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSAoQ2FyZGlvbG9neSksIFRva2Fp

IFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBUb2t5bywgSmFwYW4uJiN4RDtUaHJvbWJv

c2lzIFJlc2VhcmNoIEluc3RpdHV0ZSwgTG9uZG9uLCBVbml0ZWQgS2luZ2RvbS4mI3hEO0NvcGVu

aGFnZW4gVW5pdmVyc2l0eSBIb3NwaXRhbCwgQ29wZW5oYWdlbiwgRGVubWFyay4mI3hEO1VuaXZl

cnNpdHkgRGVnbGkgU3R1ZGkgZGkgTWlsYW5vIEJpY29jY2EsIE1pbGFuLCBJdGFseS4mI3hEO0Fy

aWFubmEgRm91bmRhdGlvbiBvbiBBbnRpY29hZ3VsYXRpb24sIEJvbG9nbmEsIEl0YWx5LiYjeEQ7

VGhyb21ib3NpcyBSZXNlYXJjaCBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgQ29sbGVnZSBMb25kb24s

IExvbmRvbiwgVW5pdGVkIEtpbmdkb20uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SXNv

bGF0ZWQgRGlzdGFsIERlZXAgVmVpbiBUaHJvbWJvc2lzOiBQZXJzcGVjdGl2ZXMgZnJvbSB0aGUg

R0FSRklFTEQtVlRFIFJlZ2lzdHJ5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlRocm9tYiBIYWVt

b3N0PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjE2NzUtMTY4NTwvcGFnZXM+PHZv

bHVtZT4xOTwvdm9sdW1lPjxudW1iZXI+MTA8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxOTwveWVh

cj48cHViLWRhdGVzPjxkYXRlPk9jdDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjI1

NjctNjg5WCAoRWxlY3Ryb25pYykmI3hEOzAzNDAtNjI0NSAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MzEzNzAwNzU8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMxMzcwMDc1PC91cmw+PHVybD5o

dHRwczovL3d3dy50aGllbWUtY29ubmVjdC5jb20vcHJvZHVjdHMvZWpvdXJuYWxzL3BkZi8xMC4x

MDU1L3MtMDAzOS0xNjkzNDYxLnBkZjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+MTAuMTA1NS9zLTAwMzktMTY5MzQ2MTwvZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZ2VubzwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MTAxPC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

NDYsIDQ3PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDEwMTwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5OTM3MDk5Ij40MTAxPC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BZ2VubywgVy48L2F1dGhvcj48YXV0

aG9yPk1hbnRvdmFuaSwgTC4gRy48L2F1dGhvcj48YXV0aG9yPkhhYXMsIFMuPC9hdXRob3I+PGF1

dGhvcj5LcmV1dHosIFIuPC9hdXRob3I+PGF1dGhvcj5Nb25qZSwgRC48L2F1dGhvcj48YXV0aG9y

PlNjaG5laWRlciwgSi48L2F1dGhvcj48YXV0aG9yPkJ1Z2dlLCBKLiBQLjwvYXV0aG9yPjxhdXRo

b3I+R2ViZWwsIE0uPC9hdXRob3I+PGF1dGhvcj5UdXJwaWUsIEEuIEcuIEcuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2lu

ZSBhbmQgU3VyZ2VyeSwgVW5pdmVyc2l0eSBvZiBJbnN1YnJpYSwgVmFyZXNlLCBJdGFseS4mI3hE

O0NFU1AtQ2VudGVyIGZvciBQdWJsaWMgSGVhbHRoIFJlc2VhcmNoLCBVbml2ZXJzaXR5IG9mIE1p

bGFuby1CaWNvY2NhLCBNb256YSwgSXRhbHkuJiN4RDtGb3JtZXJseSBJbnN0aXR1dGUgZm9yIEV4

cGVyaW1lbnRhbCBPbmNvbG9neSBhbmQgVGhlcmFweSBSZXNlYXJjaCwgVGVjaG5pY2FsIFVuaXZl

cnNpdHkgb2YgTXVuaWNoLCBNdW5pY2gsIEdlcm1hbnkuJiN4RDtDaGFyaXRlLVVuaXZlcnNpdGF0

c21lZGl6aW4gQmVybGluLCBjb3Jwb3JhdGUgbWVtYmVyIG9mIEZyZWllIFVuaXZlcnNpdGF0IEJl

cmxpbiwgSHVtYm9sZHQtVW5pdmVyc2l0YXQgenUgQmVybGluLCBhbmQgQmVybGluIEluc3RpdHV0

ZSBvZiBIZWFsdGgsIEluc3RpdHV0ZSBvZiBDbGluaWNhbCBQaGFybWFjb2xvZ3kgYW5kIFRveGlj

b2xvZ3ksIEJlcmxpbiwgR2VybWFueS4mI3hEO0JheWVyIEFHLCBCZXJsaW4sIEdlcm1hbnkuJiN4

RDtCYXllciBBRywgV3VwcGVydGFsLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2lu

ZSwgSGFtaWx0b24gSGVhbHRoIFNjaWVuY2VzLCBIYW1pbHRvbiwgT250YXJpbywgQ2FuYWRhLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlBhdGllbnQgTWFuYWdlbWVudCBTdHJhdGVnaWVz

IGFuZCBMb25nLVRlcm0gT3V0Y29tZXMgaW4gSXNvbGF0ZWQgRGlzdGFsIERlZXAtVmVpbiBUaHJv

bWJvc2lzIHZlcnN1cyBQcm94aW1hbCBEZWVwLVZlaW4gVGhyb21ib3NpczogRmluZGluZ3MgZnJv

bSBYQUxJQTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5USCBPcGVuPC9zZWNvbmRhcnktdGl0bGU+

PC90aXRsZXM+PHBhZ2VzPmU4NS1lOTM8L3BhZ2VzPjx2b2x1bWU+Mzwvdm9sdW1lPjxudW1iZXI+

MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5kZWVwLXZlaW4gdGhyb21ib3Npczwva2V5d29y

ZD48a2V5d29yZD5yaXZhcm94YWJhbjwva2V5d29yZD48a2V5d29yZD5yb3V0aW5lIGNsaW5pY2Fs

IHByYWN0aWNlPC9rZXl3b3JkPjxrZXl3b3JkPnZlbm91cyB0aHJvbWJvZW1ib2xpc208L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkph

bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjI1MTItOTQ2NSAoRWxlY3Ryb25pYykm

I3hEOzI1MTItOTQ2NSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MzEyNDk5ODc8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzMxMjQ5OTg3PC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5u

aWguZ292L3BtYy9hcnRpY2xlcy9QTUM2NTI0OTEzL3BkZi8xMC0xMDU1LXMtMDAzOS0xNjgzOTY4

LnBkZjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM2NTI0OTEzPC9jdXN0

b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDU1L3MtMDAzOS0xNjgzOTY4PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5TY2hlbGxv

bmc8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNOdW0+NDEwMjwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+NDEwMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjJlYXAwMmZmanhwemFzZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIx

NTY5OTM3MTI5Ij40MTAyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5T

Y2hlbGxvbmcsIFMuIE0uPC9hdXRob3I+PGF1dGhvcj5Hb2xkaGFiZXIsIFMuIFouPC9hdXRob3I+

PGF1dGhvcj5XZWl0eiwgSi4gSS48L2F1dGhvcj48YXV0aG9yPkFnZW5vLCBXLjwvYXV0aG9yPjxh

dXRob3I+Qm91bmFtZWF1eCwgSC48L2F1dGhvcj48YXV0aG9yPlR1cnBpZSwgQS4gRy4gRy48L2F1

dGhvcj48YXV0aG9yPkFuZ2NoYWlzdWtzaXJpLCBQLjwvYXV0aG9yPjxhdXRob3I+SGFhcywgUy48

L2F1dGhvcj48YXV0aG9yPkdvdG8sIFMuPC9hdXRob3I+PGF1dGhvcj5aYWdoZG91biwgQS48L2F1

dGhvcj48YXV0aG9yPkZhcmphdCwgQS48L2F1dGhvcj48YXV0aG9yPk5pZWxzZW4sIEouIEQuPC9h

dXRob3I+PGF1dGhvcj5LYXlhbmksIEcuPC9hdXRob3I+PGF1dGhvcj5NYW50b3ZhbmksIEwuIEcu

PC9hdXRob3I+PGF1dGhvcj5QcmFuZG9uaSwgUC48L2F1dGhvcj48YXV0aG9yPktha2thciwgQS4g

Sy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NZWRpY2Fs

IERpdmlzaW9uIDIsIE11bmljaXBhbCBIb3NwaXRhbCBEcmVzZGVuLUZyaWVkcmljaHN0YWR0LCBE

cmVzZGVuLCBHZXJtYW55LiYjeEQ7SGFydmFyZCBNZWRpY2FsIFNjaG9vbCwgSGFydmFyZCBVbml2

ZXJzaXR5LCBCb3N0b24sIE1hc3NhY2h1c2V0dHMsIFVuaXRlZCBTdGF0ZXMuJiN4RDtUaHJvbWJv

c2lzIGFuZCBBdGhlcm9zY2xlcm9zaXMgUmVzZWFyY2ggSW5zdGl0dXRlLCBNY01hc3RlciBVbml2

ZXJzaXR5LCBIYW1pbHRvbiwgT250YXJpbywgQ2FuYWRhLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRp

Y2luZSBhbmQgU3VyZ2VyeSwgVW5pdmVyc2l0eSBvZiBJbnN1YnJpYSwgVmFyZXNlLCBJdGFseS4m

I3hEO0ZhY3VsdHkgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgSG9zcGl0YWxzIG9mIEdlbmV2YSwg

R2VuZXZhLCBTd2l0emVybGFuZC4mI3hEO01jTWFzdGVyIFVuaXZlcnNpdHksIEhhbWlsdG9uLCBP

bnRhcmlvLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBSYW1hdGhpYm9kaSBI

b3NwaXRhbCwgTWFoaWRvbCBVbml2ZXJzaXR5LCBCYW5na29rLCBUaGFpbGFuZC4mI3hEO0RlcGFy

dG1lbnQgb2YgTWVkaWNpbmUsIFRlY2huaWNhbCBVbml2ZXJzaXR5IG9mIE11bmljaCwgTXVuaWNo

LCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSAoQ2FyZGlvbG9neSksIFRva2Fp

IFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBUb2t5bywgSmFwYW4uJiN4RDtUaHJvbWJv

c2lzIFJlc2VhcmNoIEluc3RpdHV0ZSwgTG9uZG9uLCBVbml0ZWQgS2luZ2RvbS4mI3hEO0NvcGVu

aGFnZW4gVW5pdmVyc2l0eSBIb3NwaXRhbCwgQ29wZW5oYWdlbiwgRGVubWFyay4mI3hEO1VuaXZl

cnNpdHkgRGVnbGkgU3R1ZGkgZGkgTWlsYW5vIEJpY29jY2EsIE1pbGFuLCBJdGFseS4mI3hEO0Fy

aWFubmEgRm91bmRhdGlvbiBvbiBBbnRpY29hZ3VsYXRpb24sIEJvbG9nbmEsIEl0YWx5LiYjeEQ7

VGhyb21ib3NpcyBSZXNlYXJjaCBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgQ29sbGVnZSBMb25kb24s

IExvbmRvbiwgVW5pdGVkIEtpbmdkb20uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SXNv

bGF0ZWQgRGlzdGFsIERlZXAgVmVpbiBUaHJvbWJvc2lzOiBQZXJzcGVjdGl2ZXMgZnJvbSB0aGUg

R0FSRklFTEQtVlRFIFJlZ2lzdHJ5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlRocm9tYiBIYWVt

b3N0PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjE2NzUtMTY4NTwvcGFnZXM+PHZv

bHVtZT4xOTwvdm9sdW1lPjxudW1iZXI+MTA8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxOTwveWVh

cj48cHViLWRhdGVzPjxkYXRlPk9jdDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjI1

NjctNjg5WCAoRWxlY3Ryb25pYykmI3hEOzAzNDAtNjI0NSAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MzEzNzAwNzU8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMxMzcwMDc1PC91cmw+PHVybD5o

dHRwczovL3d3dy50aGllbWUtY29ubmVjdC5jb20vcHJvZHVjdHMvZWpvdXJuYWxzL3BkZi8xMC4x

MDU1L3MtMDAzOS0xNjkzNDYxLnBkZjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+MTAuMTA1NS9zLTAwMzktMTY5MzQ2MTwvZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA 46, 47PerspectivesAll these new and exciting scientific data published in 2019 shed more light on the subtle, yet important, differences between atherosclerosis affecting the different peripheral vascular territories that have already started to change our clinical practice. The year 2020 is highly awaited for vascular specialists, with the completion of the Vascular Outcomes study of ASA along with rivaroxaban in endovascular or surgical limb revascularization for peripheral artery disease (VOYAGER PAD) study, that currently evaluates the efficacy and safety of bi-daily rivaroxaban at 2.5 mg in reducing the risk of major thrombotic vascular events in subjects with symptomatic peripheral artery disease undergoing peripheral revascularization procedures of the lower extremities (NCT02504216). Also a number trial data will become available addressing the safety of paclitaxel coated stents and balloons that will hopefully let us rest a peace again when using these devices. In the field of VTE, data from the CARAVAGGIO study (NCT03045406), comparing apixaban to dalteparin, for the treatment of acute VTE in cancer patients are awaited.Conflict of interestDr. Heiss reports research grants from Deutsche Forschungsgemeinschaft, Mitsubishi Cleansui, Wild Blueberry Association of North America, National Processed Raspberry Council, University of Surrey, Philips, Cranberry Institute, Rheacell; personal fees from Bayer, Novo Nordisk, Profil Institute outside the submitted work. Dr. Belch reports grants and personal fees from Bayer and Rexgenero, personal fees from Amgen, outside the submitted work. Dr. De Carlo reports personal fees from Bayer and Sanofi, outside the submitted work. Dr. Reinecke reports grants from Bard, Biotronik, Bayer, personal fees from Diaplan, MedUpdate, Daichi Sankyo, and NeoVasc, personal fees and other support from NovoNordisk ; other support from Bristol Myers Squibb and Pfizer; grants, personal fees, and other support from Pluristem outside the submitted work and is the senior author of a manuscript which is presented/reviewed in this article. Dr. Pitcher reports personal fees from Actelion Pharmaceuticals Ltd and from Bristol-Myers Squibb Pharmaceuticals Limited, outside the submitted work. Dr. Aboyans declares personal fees from Amgen, Bayer, Novartis, NovoNordisk, BMS/Pfizer alliance and Sanofi, as speaker or advisor. Dr. Mazzolai and Dr. Baumgartner have nothing to disclose. References ADDIN EN.REFLIST 1.De Carlo M, Mazzolai L, Bossone E, Brodmann M, Micari A, Muiesan ML, Ricco JB, Stabile E, Agnelli G, Aboyans V, Aorta ESCWGo, Peripheral Vascular D. The year in cardiology 2016: peripheral circulation. Eur Heart J 2017;38:1028-1033.2.Aboyans V, Vrsalovic M, Madaric J, Mazzolai L, De Carlo M, Aorta ESCWGo, Peripheral Vascular D. The year 2018 in cardiology: aorta and peripheral circulation. Eur Heart J 2019;40:872-879.3.Aboyans V, Braekkan S, Mazzolai L, Sillesen H, Venermo M, De Carlo M, Aorta ESCWGo, Peripheral Vascular D. The year 2017 in cardiology: aorta and peripheral circulation. Eur Heart J 2018;39:730-738.4.Aboyans V, Ricco JB, Bartelink MEL, Bjorck M, Brodmann M, Cohnert T, Collet JP, Czerny M, De Carlo M, Debus S, Espinola-Klein C, Kahan T, Kownator S, Mazzolai L, Naylor AR, Roffi M, Rother J, Sprynger M, Tendera M, Tepe G, Venermo M, Vlachopoulos C, Desormais I, Group ESCSD. 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed by: the European Stroke Organization (ESO)The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS). Eur Heart J 2018;39:763-816.5.Klarin D, Lynch J, Aragam K, Chaffin M, Assimes TL, Huang J, Lee KM, Shao Q, Huffman JE, Natarajan P, Arya S, Small A, Sun YV, Vujkovic M, Freiberg MS, Wang L, Chen J, Saleheen D, Lee JS, Miller DR, Reaven P, Alba PR, Patterson OV, DuVall SL, Boden WE, Beckman JA, Gaziano JM, Concato J, Rader DJ, Cho K, Chang KM, Wilson PWF, O'Donnell CJ, Kathiresan S, Program VAMV, Tsao PS, Damrauer SM. Genome-wide association study of peripheral artery disease in the Million Veteran Program. Nat Med 2019;25:1274-1279.6.Leisegang MS, Bibli SI, Gunther S, Pfluger-Muller B, Oo JA, Hoper C, Seredinski S, Yekelchyk M, Schmitz-Rixen T, Schurmann C, Hu J, Looso M, Sigala F, Boon RA, Fleming I, Brandes RP. Pleiotropic effects of laminar flow and statins depend on the Kruppel-like factor-induced lncRNA MANTIS. Eur Heart J 2019;40:2523-2533.7.Oppi S, Nusser-Stein S, Blyszczuk P, Wang X, Jomard A, Marzolla V, Yang K, Velagapudi S, Ward LJ, Yuan XM, Geiger MA, Guillaumon AT, Othman A, Hornemann T, Rancic Z, Ryu D, Oosterveer MH, Osto E, Luscher TF, Stein S. Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARgamma signature. Eur Heart J 2019.8.Christersdottir T, Pirault J, Gistera A, Bergman O, Gallina AL, Baumgartner R, Lundberg AM, Eriksson P, Yan ZQ, Paulsson-Berne G, Hansson GK, Olofsson PS, Halle M. Prevention of radiotherapy-induced arterial inflammation by interleukin-1 blockade. Eur Heart J 2019;40:2495-2503.9.Stiekema LCA, Stroes ESG, Verweij SL, Kassahun H, Chen L, Wasserman SM, Sabatine MS, Mani V, Fayad ZA. Persistent arterial wall inflammation in patients with elevated lipoprotein(a) despite strong low-density lipoprotein cholesterol reduction by proprotein convertase subtilisin/kexin type 9 antibody treatment. Eur Heart J 2019;40:2775-2781.10.Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, Chapman MJ, De Backer GG, Delgado V, Ference BA, Graham IM, Halliday A, Landmesser U, Mihaylova B, Pedersen TR, Riccardi G, Richter DJ, Sabatine MS, Taskinen MR, Tokgozoglu L, Wiklund O, Group ESCSD. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J 2019.11.Tzoulaki I, Castagne R, Boulange CL, Karaman I, Chekmeneva E, Evangelou E, Ebbels TMD, Kaluarachchi MR, Chadeau-Hyam M, Mosen D, Dehghan A, Moayyeri A, Ferreira DLS, Guo X, Rotter JI, Taylor KD, Kavousi M, de Vries PS, Lehne B, Loh M, Hofman A, Nicholson JK, Chambers J, Gieger C, Holmes E, Tracy R, Kooner J, Greenland P, Franco OH, Herrington D, Lindon JC, Elliott P. Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease. Eur Heart J 2019;40:2883-2896.12.Fernandez-Friera L, Fuster V, Lopez-Melgar B, Oliva B, Sanchez-Gonzalez J, Macias A, Perez-Asenjo B, Zamudio D, Alonso-Farto JC, Espana S, Mendiguren J, Bueno H, Garcia-Ruiz JM, Ibanez B, Fernandez-Ortiz A, Sanz J. Vascular Inflammation in Subclinical Atherosclerosis Detected by Hybrid PET/MRI. J Am Coll Cardiol 2019;73:1371-1382.13.Charakida M, Georgiopoulos G, Dangardt F, Chiesa ST, Hughes AD, Rapala A, Davey Smith G, Lawlor D, Finer N, Deanfield JE. Early vascular damage from smoking and alcohol in teenage years: the ALSPAC study. Eur Heart J 2019;40:345-353.14.Mortensen MB, Fuster V, Muntendam P, Mehran R, Baber U, Sartori S, Falk E. Negative Risk Markers for Cardiovascular Events in the Elderly. J Am Coll Cardiol 2019;74:1-11.15.Naslund U, Ng N, Lundgren A, Fharm E, Gronlund C, Johansson H, Lindahl B, Lindahl B, Lindvall K, Nilsson SK, Nordin M, Nordin S, Nyman E, Rocklov J, Vanoli D, Weinehall L, Wennberg P, Wester P, Norberg M, group Vt. Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA): a pragmatic, open-label, randomised controlled trial. Lancet 2019;393:133-142.16.Song P, Rudan D, Zhu Y, Fowkes FJI, Rahimi K, Fowkes FGR, Rudan I. Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis. Lancet Glob Health 2019;7:e1020-e1030.17.Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS. Microvascular Disease, Peripheral Artery Disease, and Amputation. Circulation 2019;140:449-458.18.Hess CN, Huang Z, Patel MR, Baumgartner I, Berger JS, Blomster JI, Fowkes FGR, Held P, Jones WS, Katona B, Mahaffey KW, Norgren L, Rockhold FW, Hiatt WR. Acute Limb Ischemia in Peripheral Artery Disease. Circulation 2019;140:556-565.19.Baumgartner I, Norgren L, Fowkes FGR, Mulder H, Patel MR, Berger JS, Jones WS, Rockhold FW, Katona BG, Mahaffey K, Hiatt WR, Executive C, Investigators of the ET. Cardiovascular Outcomes After Lower Extremity Endovascular or Surgical Revascularization: The EUCLID Trial. J Am Coll Cardiol 2018;72:1563-1572.20.Navi BB, Reiner AS, Kamel H, Iadecola C, Okin PM, Tagawa ST, Panageas KS, DeAngelis LM. Arterial thromboembolic events preceding the diagnosis of cancer in older persons. Blood 2019;133:781-789.21.Jukema JW, Szarek M, Zijlstra LE, de Silva HA, Bhatt DL, Bittner VA, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Karpov Y, Moryusef A, Pordy R, Prieto JC, Roe MT, White HD, Zeiher AM, Schwartz GG, Steg PG, Committees OO, Investigators. Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial. J Am Coll Cardiol 2019;74:1167-1176.22.Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J 2018;39:3021-3104.23.Lu Y, Ballew SH, Tanaka H, Szklo M, Heiss G, Coresh J, Matsushita K. 2017 ACC/AHA blood pressure classification and incident peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study. Eur J Prev Cardiol 2019:2047487319865378.24.McDermott MM, Kibbe MR, Guralnik JM, Ferrucci L, Criqui MH, Domanchuk K, Tian L, Zhao L, Li L, Patel K, Polonsky TS. Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease. J Am Heart Assoc 2019;8:e009380.25.Lin E, Nguyen CH, Thomas SG. Completion and adherence rates to exercise interventions in intermittent claudication: Traditional exercise versus alternative exercise - a systematic review. Eur J Prev Cardiol 2019:2047487319846997.26.Lin JH, Brunson A, Romano PS, Mell MW, Humphries MD. Endovascular-First Treatment Is Associated With Improved Amputation-Free Survival in Patients With Critical Limb Ischemia. Circ Cardiovasc Qual Outcomes 2019;12:e005273.27.Laird JA, Schneider PA, Jaff MR, Brodmann M, Zeller T, Metzger DC, Krishnan P, Scheinert D, Micari A, Wang H, Masters M, Tepe G. Long-Term Clinical Effectiveness of a Drug-Coated Balloon for the Treatment of Femoropopliteal Lesions. Circ Cardiovasc Interv 2019;12:e007702.28.Katsanos K, Spiliopoulos S, Kitrou P, Krokidis M, Karnabatidis D. Risk of Death Following Application of Paclitaxel-Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc 2018;7:e011245.29.Freisinger E, Koeppe J, Gerss J, Goerlich D, Malyar N, Marschall U, Faldum A, Reinecke H. Mortality after use of paclitaxel-based devices in peripheral arteries: a real-world safety analysis. Eur Heart J 2019;Epub ahead of print.30.Nazerian P, Mueller C, Vanni S, Soeiro AM, Leidel BA, Cerini G, Lupia E, Palazzo A, Grifoni S, Morello F. Integration of transthoracic focused cardiac ultrasound in the diagnostic algorithm for suspected acute aortic syndromes. Eur Heart J 2019;40:1952-1960.31.Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwoger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, Allmen RS, Vrints CJ, Guidelines ESCCfP. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur Heart J 2014;35:2873-2926.32.Ahn JM, Kim H, Kwon O, Om SY, Heo R, Lee S, Kim DH, Kim HJ, Kim JB, Jung SH, Choo SJ, Song JM, Kang DH, Chung CH, Lee JW, Song JK. Differential clinical features and long-term prognosis of acute aortic syndrome according to disease entity. Eur Heart J 2019;40:2727-2736.33.Guala A, Teixido-Tura G, Rodriguez-Palomares J, Ruiz-Munoz A, Dux-Santoy L, Villalva N, Granato C, Galian L, Gutierrez L, Gonzalez-Alujas T, Sanchez V, Forteza A, Garcia-Dorado D, Evangelista A. Proximal aorta longitudinal strain predicts aortic root dilation rate and aortic events in Marfan syndrome. Eur Heart J 2019;40:2047-2055.34.Habashi JP, MacFarlane EG, Bagirzadeh R, Bowen C, Huso N, Chen Y, Bedja D, Creamer TJ, Rykiel G, Manning M, Huso D, Dietz HC. Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome. Sci Transl Med 2019;11.35.Desai D, Miranda W, Connolly H, Tajik AJ. Flow dynamics in the false lumen in distal aorta following surgery for type A aortic dissection. Eur Heart J 2019;40:561.36.Chiu P, Goldstone AB, Schaffer JM, Lingala B, Miller DC, Mitchell RS, Woo YJ, Fischbein MP, Dake MD. Endovascular Versus Open Repair of Intact Descending Thoracic Aortic Aneurysms. J Am Coll Cardiol 2019;73:643-651.37.Lederle FA, Kyriakides TC, Stroupe KT, Freischlag JA, Padberg FT, Jr., Matsumura JS, Huo Z, Johnson GR, Group OVACS. Open versus Endovascular Repair of Abdominal Aortic Aneurysm. N Engl J Med 2019;380:2126-2135.38.Chiesa ST, Masi S, Shipley MJ, Ellins EA, Fraser AG, Hughes AD, Patel RS, Khir AW, Halcox JP, Singh-Manoux A, Kivimaki M, Celermajer DS, Deanfield JE. Carotid artery wave intensity in mid- to late-life predicts cognitive decline: the Whitehall II study. Eur Heart J 2019;40:2300-2309.39.Reddy VY, Neuzil P, de Potter T, van der Heyden J, Tromp SC, Rensing B, Jiresova E, Dujka L, Lekesova V. Permanent Percutaneous Carotid Artery Filter to Prevent Stroke in Atrial Fibrillation Patients: The CAPTURE Trial. J Am Coll Cardiol 2019;74:829-839.40.Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, Huisman MV, Humbert M, Jennings CS, Jimenez D, Kucher N, Lang IM, Lankeit M, Lorusso R, Mazzolai L, Meneveau N, Ni Ainle F, Prandoni P, Pruszczyk P, Righini M, Torbicki A, Van Belle E, Zamorano JL, Group ESCSD. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 2019.41.Barco S, Schmidtmann I, Ageno W, Bauersachs RM, Becattini C, Bernardi E, Beyer-Westendorf J, Bonacchini L, Brachmann J, Christ M, Czihal M, Duerschmied D, Empen K, Espinola-Klein C, Ficker JH, Fonseca C, Genth-Zotz S, Jimenez D, Harjola VP, Held M, Iogna Prat L, Lange TJ, Manolis A, Meyer A, Mustonen P, Rauch-Kroehnert U, Ruiz-Artacho P, Schellong S, Schwaiblmair M, Stahrenberg R, Westerweel PE, Wild PS, Konstantinides SV, Lankeit M, Ho TPEI. Early discharge and home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban: an international multicentre single-arm clinical trial. Eur Heart J 2019.42.Barco S, Mahmoudpour SH, Planquette B, Sanchez O, Konstantinides SV, Meyer G. Prognostic value of right ventricular dysfunction or elevated cardiac biomarkers in patients with low-risk pulmonary embolism: a systematic review and meta-analysis. Eur Heart J 2019;40:902-910.43.van der Pol LM, Tromeur C, Bistervels IM, Ni Ainle F, van Bemmel T, Bertoletti L, Couturaud F, van Dooren YPA, Elias A, Faber LM, Hofstee HMA, van der Hulle T, Kruip M, Maignan M, Mairuhu ATA, Middeldorp S, Nijkeuter M, Roy PM, Sanchez O, Schmidt J, Ten Wolde M, Klok FA, Huisman MV, Artemis Study I. Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism. N Engl J Med 2019;380:1139-1149.44.Valerio L, Ambaglio C, Barone M, Ciola M, Konstantinides SV, Mahmoudpour SH, Picchi C, Pieresca C, Trinchero A, Barco S. Recurrence Risk after First Symptomatic Distal versus Proximal Deep Vein Thrombosis According to Baseline Risk Factors. TH Open 2019;3:e58-e63.45.Mazzolai L, Aboyans V, Ageno W, Agnelli G, Alatri A, Bauersachs R, Brekelmans MPA, Buller HR, Elias A, Farge D, Konstantinides S, Palareti G, Prandoni P, Righini M, Torbicki A, Vlachopoulos C, Brodmann M. Diagnosis and management of acute deep vein thrombosis: a joint consensus document from the European Society of Cardiology working groups of aorta and peripheral vascular diseases and pulmonary circulation and right ventricular function. Eur Heart J 2018;39:4208-4218.46.Ageno W, Mantovani LG, Haas S, Kreutz R, Monje D, Schneider J, Bugge JP, Gebel M, Turpie AGG. Patient Management Strategies and Long-Term Outcomes in Isolated Distal Deep-Vein Thrombosis versus Proximal Deep-Vein Thrombosis: Findings from XALIA. TH Open 2019;3:e85-e93.47.Schellong SM, Goldhaber SZ, Weitz JI, Ageno W, Bounameaux H, Turpie AGG, Angchaisuksiri P, Haas S, Goto S, Zaghdoun A, Farjat A, Nielsen JD, Kayani G, Mantovani LG, Prandoni P, Kakkar AK. Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry. Thromb Haemost 2019;19:1675-1685.48.Torbicki A. Assessing the severity of acute pulmonary embolism: back to the future? Eur Heart J 2019;40:911-913.Figure legendsFigure 1. A translational model for therapeutic target discovery in radiation injury. Clinical event: Increased risk for cardiovascular disease at the site of previous radiotherapy. Human biobank: Gene expression array of paired (irradiated and non-irradiated) human arteries retrieved at the same time during microvascular autologous free tissue transfers for reconstructive cancer surgery. Radiotherapy induces a sustained inflammatory response in human arteries. Animal model: Establishment of an animal model of local irradiation with similar inflammatory patterns as observed in the human biobank. Treatment: Treatment with anakinra (IL-1R antagonist) reduced radiation-induced vascular inflammation in our Apoe-/- mouse model of local irradiation. Ctl, non-irradiated; Ccl2/Mcp-1, chemokine (C-C motif) ligand2/monocyte chemoattractant protein-1; DAMP, dam- age associated molecular pattern; IL-1R, interleukin-1 receptor; ROS, reactive oxygen species; VCAM1, vascular cell adhesion molecule-1; XRT, irradiated.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaHJpc3RlcnNkb3R0aXI8L0F1dGhvcj48WWVhcj4yMDE5

PC9ZZWFyPjxSZWNOdW0+NDA3MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3Vw

ZXJzY3JpcHQiPjg8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDcy

PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZq

eHB6YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkwNjE2MDkiPjQwNzI8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNocmlzdGVyc2RvdHRpciwg

VC48L2F1dGhvcj48YXV0aG9yPlBpcmF1bHQsIEouPC9hdXRob3I+PGF1dGhvcj5HaXN0ZXJhLCBB

LjwvYXV0aG9yPjxhdXRob3I+QmVyZ21hbiwgTy48L2F1dGhvcj48YXV0aG9yPkdhbGxpbmEsIEEu

IEwuPC9hdXRob3I+PGF1dGhvcj5CYXVtZ2FydG5lciwgUi48L2F1dGhvcj48YXV0aG9yPkx1bmRi

ZXJnLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+RXJpa3Nzb24sIFAuPC9hdXRob3I+PGF1dGhvcj5Z

YW4sIFouIFEuPC9hdXRob3I+PGF1dGhvcj5QYXVsc3Nvbi1CZXJuZSwgRy48L2F1dGhvcj48YXV0

aG9yPkhhbnNzb24sIEcuIEsuPC9hdXRob3I+PGF1dGhvcj5PbG9mc3NvbiwgUC4gUy48L2F1dGhv

cj48YXV0aG9yPkhhbGxlLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgTW9sZWN1bGFyIE1lZGljaW5lIGFuZCBTdXJnZXJ5LCBL

YXJvbGluc2thIEluc3RpdHV0ZXQsIEthcm9saW5za2EgVW5pdmVyc2l0eSBIb3NwaXRhbCwgU3Rv

Y2tob2xtLCBTd2VkZW4uJiN4RDtTdC4gRXJpayBFeWUgSG9zcGl0YWwsIFN0b2NraG9sbSwgU3dl

ZGVuLiYjeEQ7Q2FyZGlvdmFzY3VsYXIgTWVkaWNpbmUgVW5pdCwgRGVwYXJ0bWVudCBvZiBNZWRp

Y2luZSwgQ2VudGVyIGZvciBNb2xlY3VsYXIgTWVkaWNpbmUsIEthcm9saW5za2EgSW5zdGl0dXRl

dCBhbmQgS2Fyb2xpbnNrYSBVbml2ZXJzaXR5IEhvc3BpdGFsLCBCaW9jbGluaWN1bSBKODoyMCwg

VmlzaW9uc2dhdGFuIDQsIFN0b2NraG9sbSwgU3dlZGVuLiYjeEQ7UmVjb25zdHJ1Y3RpdmUgUGxh

c3RpYyBTdXJnZXJ5LCBLYXJvbGluc2thIFVuaXZlcnNpdHkgSG9zcGl0YWwsIFN0b2NraG9sbSwg

U3dlZGVuLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlByZXZlbnRpb24gb2YgcmFkaW90

aGVyYXB5LWluZHVjZWQgYXJ0ZXJpYWwgaW5mbGFtbWF0aW9uIGJ5IGludGVybGV1a2luLTEgYmxv

Y2thZGU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+MjQ5NS0yNTAzPC9wYWdlcz48dm9sdW1lPjQwPC92b2x1bWU+PG51

bWJlcj4zMDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbmFraW5yYTwva2V5d29yZD48a2V5

d29yZD5DY2wyPC9rZXl3b3JkPjxrZXl3b3JkPkludGVybGV1a2luLTE8L2tleXdvcmQ+PGtleXdv

cmQ+TWNwLTE8L2tleXdvcmQ+PGtleXdvcmQ+UmFkaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlZh

c2N1bGFyIGRpc2Vhc2U8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVh

cj48cHViLWRhdGVzPjxkYXRlPkF1ZyA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNj

ZXNzaW9uLW51bT4zMTA4MTAzODwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1

cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzEwODEwMzg8L3VybD48dXJs

Pmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcG1jL2FydGljbGVzL1BNQzY2ODUzMjgvcGRm

L2VoejIwNi5wZGY8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9l

aHoyMDYucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3Fm

S0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJBRENDQW1JR0NT

cUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTVFEeDJfSjE1cFRyUnV4MEhBZ0VRZ0lJ

Q002WW5aTGhocnpuenBsay1XQjl1Zzg5QkNfaDgxUDhqSDBqaVBGZGY4ekNkZkE4d1h0aG1ZaTJF

em5aVFl2QmIxZmRQbE4xT0I3ZmR3Ui1jeXNpa19FUVA2R1Y3NUw2Z0FOT1lfamVteUYxaHM3LUdU

Y0FlVHFkOXN5aDFmbThTMkQta01SdXd6eVBJYURQUUI3dlBLQTJvYzNBWENUM2lzajE2WEh0VFpN

dUxBVUxXSGY1WkpqdkpUbXdlamVWb0VnODI5Q2o4VGhBTG5YSU5WY19MQWRrVGdKbTV1TTFKcnRI

ZDZOeks5X0hIR2VISjVld1VxMWR2LXI1d0FrcXdNQUt0LU9JRl9UejBvZWJRb2lYX1RhLThGdmF1

OXFrU1Fzcjg0dEpkTmxkUGxaM1VaZmlwQy1uOVlTUkdtU0I3RFlpbHdGV2FuQXdvSHZXUHBGWDVG

WHh0anNzX0xiVjZIWEc3UmlUcE1IT2VVdXlXZEZfSWd2eFRvd1ZVRDRMcU5DVkJSa0dZd2twSDBW

NW9wd3VIUzlLM3ZWbC1IZE1iOC1GckZnUnUwRkM1SUR3WHp2cXZwOGVOcmZTbzZZeHd1SUpqZjFz

eURlS3JlVlpOc3ZKTGgyU1V4c1ZxRFZRaDFfeG43Xzl3WHp4STdiRklmY2ZuNE1FSGV2cjdrMFhz

VVNMUzJicm1vUGljRkhVZkJ1RURiMDFseHM4NHFua2NLNjd0eTduTFhnTjh3MGJxMzNGZEVBV3JK

RnRNMTVIWVlNTm54VzV3TXhxbi1oeVBZcm54MXJzM2tHd2xWbDlCcXhFVTZDeU9TZDNJZ3QtdDBf

Mm1KRWRxYlJuTlUtQjhSWG1tSUw1UWVtUThSVXB1Y1JTdkZLS2VzQk9aWkRIT0ZtbmZEb1JxWDVN

MENNN0hjVWJzNnhydklQdGc1cXdzUWIzQV9nVTREdV9hZHBQdjhtWEhHc3pQOVoxR1lpemNqNFE1

SjVEZElZV1h0cWdpPC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3BtYy9h

cnRpY2xlcy9QTUM2Njg1MzI4LzwvdXJsPjx1cmw+aHR0cHM6Ly93YXRlcm1hcmsuc2lsdmVyY2hh

aXIuY29tL2VoejIwNi5wZGY/dG9rZW49QVFFQ0FIaTIwOEJFNDlPb2FuOWtraFdfRXJjeTdEbTNa

TF85Q2YzcWZLQWM0ODV5c2dBQUFvQXdnZ0o4QmdrcWhraUc5dzBCQndhZ2dnSnRNSUlDYVFJQkFE

Q0NBbUlHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFNRUFTNHdFUVFNSVpKSENLU0NKUG5MTm9l

QUFnRVFnSUlDTTM3dlJ6bjlYT2cwVHhyS0o4NzhsWXJQNi1jUHNyN3oydHhXX0hlV1J4NkZkTnFS

a2RwWFVicjd5WDEzTWxWREszMFRNUTVDRnJsR2ttQUh4c1lOM0JsTGZTUlhGcEFhZFpTcXNTTEYx

b0pVR3lha2FRWUFKM216WUVieDhEN1d2Z213Y0xjSUtuek5Ic1ZUc3Vha2dUSzZfbk9Cd0ZzY2Iw

TEZNam01R2lHdjVqN1YzN3J1eDlTZDBWWUpqcC1Vd0pTTWtvMGQyR1pwcXhGZmFCcWtTaUZiYklP

d2lNdlhoS2h0bmtYcHk5QmRDdXZBZkRuMWRZTXlaY25xX3VGZlpzSWF5VWZSRGhNZzN2cGhOZUtR

SUFSNXg0RUVfWmRfREM1YjhMa2QxTUpiemF3N003VkN1WDhRV2ZwMEFYbW1McUk5bGtDVlN2cGRX

VUFWVDVCZkg4V2NPLVNER19UQms3UWxIYkttbGxjNWhZR0t0czR0NGhzVDBxVXhyYm1jZFlGc2hl

d3J0NDhVRHY1UlEwbGpZZHIwMXZkQ1JfZEZGU21WZWpuaWhtU0diNHYtaFlkM1d5ZU1oZUtCWHVM

Y2R4aEVic1NjSW1kUENteTBTZGpyWHFHQkZFX2dMdElXVE1tYWlDT2NJYUwtWGFjVDloZWNDM2pE

bnIxUTlaZzdranM3aEtpR3dUVTg5YVUtWXBjck9OX2VtVkZRVTRaYTBaZDZxdVB6ZXlsVmpYSnVw

eXZEVVZRZ0Iyb3JSRHdId25yTjlKU1hzcUctcGFqSm9oTk5vS3gwRHI0M2NTd21jTGI2eUxIM29s

b3VuMHVMc25kUlYzV2lNaVlpOUFIR2laTTFJdzdCbUs2SWFXVEd0cVE0Qk55dG9kdy13NFc1NWFt

ckJCTlk2ZkprdENmWHlhekZrSFBTTWh2dllCanBVS29icWlQbnV2N0I1Ni1PcW5iM284NjFoYWQw

YXMweVlLWmlXWDNBSG1TVmNpWlc8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNo

YWlyLmNvbS9laHoyMDYucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0z

WkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJB

RENDQW1JR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTXF0OUk4Mmd2X3IxRjlo

VUVBZ0VRZ0lJQ002SnAxcmxjSE81aGkyN0Z0aXVtZFBoSFdGWDBYNDZGSVUtS2hRTG1FTUh1aERZ

dzZxbDd3R05Wc2k2X2lKMm16N1dhNjhUdHBiZkM2WGM3Z3pJaHpEOFBwNTdFV3k5a3c1Qi0yckNl

dFA3cmVkQ05ORFU5c3NhalY4S3FfcGx4T2FxUk51MVhXRzZMc2hWOXhuZy1sa2VnaXowMHUzbENv

amRhZGVGMjV2UUlaYmJIRGk1ZEthV2xCcmFMMW9EZU0zWWZUajQ0elUzUDk1cTRCOEVTMnp1QjVj

dDJ0UGpDX3pVNHQzbU5nUjVoMmpUakJsQ0twME9PbjlhcXBhSFBNRkZULVRRaVVqMHpzQ3lsVWJZ

MzBXMEU1c09lMUZuaXVzMlR2NEpqLTZHZFdmRmlUZGcxOHU5NXNMUGJoM3h0NC1IbjJXMUtBcTFX

NjF3V2lxcXN2eVVpYjdXYTdBeFZTQnU0Q3dVakdqc0FSXzNvRG9mQ0l5Qm0wUHZDbndhSEU0WHZp

d2lJeHhIdGxVM3hNVHVvbXVidk84QzJtcUVrQ3BTMXpGYUgxOHVaWHNVWDd0Qk1SRk5lclVpQmhk

Zk9rYlM4aGZIVTNJYVhZUXdXSzBZRzBXLTJ1Q0NaeEJVdnR0UW1vUDhwZTlhbndDVVlaeTVaTlRV

YWhaeHRnUE4tVkpScklBT28xZUhGU0w3V0lIZDRKbzdRS2xEbEtYVU44TG02SDBndGpZcXM0R3U0

RnROcG8wYmJPRVZLZ29SM0NaTFhsU1djNERGN3ctbEVJVThPOXZrX29NNTU0UWdrRjNJU2kxSThU

SVNuVFVYOTAwYzc3Um80TmUzZ0l6M3FTeGJNUC1kaTFrdTk2dHcwTDN5ZkZ2alR3blhhLU93cU5p

QTg2SHFhR2pUY0lGT3E3VXc3NUlnQ0JOdVJHLXFyTlpqcDRUVGFiWlQ1VzZ2WEdoTWRyQk5MYVZL

UG5UVVloRG1ZTXRZVWxHVTZCRGR2PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20y

PlBNQzY2ODUzMjg8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVy

aGVhcnRqL2VoejIwNjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaHJpc3RlcnNkb3R0aXI8L0F1dGhvcj48WWVhcj4yMDE5

PC9ZZWFyPjxSZWNOdW0+NDA3MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3Vw

ZXJzY3JpcHQiPjg8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MDcy

PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZq

eHB6YXNlczJyNzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1NjkwNjE2MDkiPjQwNzI8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNocmlzdGVyc2RvdHRpciwg

VC48L2F1dGhvcj48YXV0aG9yPlBpcmF1bHQsIEouPC9hdXRob3I+PGF1dGhvcj5HaXN0ZXJhLCBB

LjwvYXV0aG9yPjxhdXRob3I+QmVyZ21hbiwgTy48L2F1dGhvcj48YXV0aG9yPkdhbGxpbmEsIEEu

IEwuPC9hdXRob3I+PGF1dGhvcj5CYXVtZ2FydG5lciwgUi48L2F1dGhvcj48YXV0aG9yPkx1bmRi

ZXJnLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+RXJpa3Nzb24sIFAuPC9hdXRob3I+PGF1dGhvcj5Z

YW4sIFouIFEuPC9hdXRob3I+PGF1dGhvcj5QYXVsc3Nvbi1CZXJuZSwgRy48L2F1dGhvcj48YXV0

aG9yPkhhbnNzb24sIEcuIEsuPC9hdXRob3I+PGF1dGhvcj5PbG9mc3NvbiwgUC4gUy48L2F1dGhv

cj48YXV0aG9yPkhhbGxlLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgTW9sZWN1bGFyIE1lZGljaW5lIGFuZCBTdXJnZXJ5LCBL

YXJvbGluc2thIEluc3RpdHV0ZXQsIEthcm9saW5za2EgVW5pdmVyc2l0eSBIb3NwaXRhbCwgU3Rv

Y2tob2xtLCBTd2VkZW4uJiN4RDtTdC4gRXJpayBFeWUgSG9zcGl0YWwsIFN0b2NraG9sbSwgU3dl

ZGVuLiYjeEQ7Q2FyZGlvdmFzY3VsYXIgTWVkaWNpbmUgVW5pdCwgRGVwYXJ0bWVudCBvZiBNZWRp

Y2luZSwgQ2VudGVyIGZvciBNb2xlY3VsYXIgTWVkaWNpbmUsIEthcm9saW5za2EgSW5zdGl0dXRl

dCBhbmQgS2Fyb2xpbnNrYSBVbml2ZXJzaXR5IEhvc3BpdGFsLCBCaW9jbGluaWN1bSBKODoyMCwg

VmlzaW9uc2dhdGFuIDQsIFN0b2NraG9sbSwgU3dlZGVuLiYjeEQ7UmVjb25zdHJ1Y3RpdmUgUGxh

c3RpYyBTdXJnZXJ5LCBLYXJvbGluc2thIFVuaXZlcnNpdHkgSG9zcGl0YWwsIFN0b2NraG9sbSwg

U3dlZGVuLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlByZXZlbnRpb24gb2YgcmFkaW90

aGVyYXB5LWluZHVjZWQgYXJ0ZXJpYWwgaW5mbGFtbWF0aW9uIGJ5IGludGVybGV1a2luLTEgYmxv

Y2thZGU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+MjQ5NS0yNTAzPC9wYWdlcz48dm9sdW1lPjQwPC92b2x1bWU+PG51

bWJlcj4zMDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbmFraW5yYTwva2V5d29yZD48a2V5

d29yZD5DY2wyPC9rZXl3b3JkPjxrZXl3b3JkPkludGVybGV1a2luLTE8L2tleXdvcmQ+PGtleXdv

cmQ+TWNwLTE8L2tleXdvcmQ+PGtleXdvcmQ+UmFkaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlZh

c2N1bGFyIGRpc2Vhc2U8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVh

cj48cHViLWRhdGVzPjxkYXRlPkF1ZyA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNj

ZXNzaW9uLW51bT4zMTA4MTAzODwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1

cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzEwODEwMzg8L3VybD48dXJs

Pmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcG1jL2FydGljbGVzL1BNQzY2ODUzMjgvcGRm

L2VoejIwNi5wZGY8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNvbS9l

aHoyMDYucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNmM3Fm

S0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJBRENDQW1JR0NT

cUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTVFEeDJfSjE1cFRyUnV4MEhBZ0VRZ0lJ

Q002WW5aTGhocnpuenBsay1XQjl1Zzg5QkNfaDgxUDhqSDBqaVBGZGY4ekNkZkE4d1h0aG1ZaTJF

em5aVFl2QmIxZmRQbE4xT0I3ZmR3Ui1jeXNpa19FUVA2R1Y3NUw2Z0FOT1lfamVteUYxaHM3LUdU

Y0FlVHFkOXN5aDFmbThTMkQta01SdXd6eVBJYURQUUI3dlBLQTJvYzNBWENUM2lzajE2WEh0VFpN

dUxBVUxXSGY1WkpqdkpUbXdlamVWb0VnODI5Q2o4VGhBTG5YSU5WY19MQWRrVGdKbTV1TTFKcnRI

ZDZOeks5X0hIR2VISjVld1VxMWR2LXI1d0FrcXdNQUt0LU9JRl9UejBvZWJRb2lYX1RhLThGdmF1

OXFrU1Fzcjg0dEpkTmxkUGxaM1VaZmlwQy1uOVlTUkdtU0I3RFlpbHdGV2FuQXdvSHZXUHBGWDVG

WHh0anNzX0xiVjZIWEc3UmlUcE1IT2VVdXlXZEZfSWd2eFRvd1ZVRDRMcU5DVkJSa0dZd2twSDBW

NW9wd3VIUzlLM3ZWbC1IZE1iOC1GckZnUnUwRkM1SUR3WHp2cXZwOGVOcmZTbzZZeHd1SUpqZjFz

eURlS3JlVlpOc3ZKTGgyU1V4c1ZxRFZRaDFfeG43Xzl3WHp4STdiRklmY2ZuNE1FSGV2cjdrMFhz

VVNMUzJicm1vUGljRkhVZkJ1RURiMDFseHM4NHFua2NLNjd0eTduTFhnTjh3MGJxMzNGZEVBV3JK

RnRNMTVIWVlNTm54VzV3TXhxbi1oeVBZcm54MXJzM2tHd2xWbDlCcXhFVTZDeU9TZDNJZ3QtdDBf

Mm1KRWRxYlJuTlUtQjhSWG1tSUw1UWVtUThSVXB1Y1JTdkZLS2VzQk9aWkRIT0ZtbmZEb1JxWDVN

MENNN0hjVWJzNnhydklQdGc1cXdzUWIzQV9nVTREdV9hZHBQdjhtWEhHc3pQOVoxR1lpemNqNFE1

SjVEZElZV1h0cWdpPC91cmw+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3BtYy9h

cnRpY2xlcy9QTUM2Njg1MzI4LzwvdXJsPjx1cmw+aHR0cHM6Ly93YXRlcm1hcmsuc2lsdmVyY2hh

aXIuY29tL2VoejIwNi5wZGY/dG9rZW49QVFFQ0FIaTIwOEJFNDlPb2FuOWtraFdfRXJjeTdEbTNa

TF85Q2YzcWZLQWM0ODV5c2dBQUFvQXdnZ0o4QmdrcWhraUc5dzBCQndhZ2dnSnRNSUlDYVFJQkFE

Q0NBbUlHQ1NxR1NJYjNEUUVIQVRBZUJnbGdoa2dCWlFNRUFTNHdFUVFNSVpKSENLU0NKUG5MTm9l

QUFnRVFnSUlDTTM3dlJ6bjlYT2cwVHhyS0o4NzhsWXJQNi1jUHNyN3oydHhXX0hlV1J4NkZkTnFS

a2RwWFVicjd5WDEzTWxWREszMFRNUTVDRnJsR2ttQUh4c1lOM0JsTGZTUlhGcEFhZFpTcXNTTEYx

b0pVR3lha2FRWUFKM216WUVieDhEN1d2Z213Y0xjSUtuek5Ic1ZUc3Vha2dUSzZfbk9Cd0ZzY2Iw

TEZNam01R2lHdjVqN1YzN3J1eDlTZDBWWUpqcC1Vd0pTTWtvMGQyR1pwcXhGZmFCcWtTaUZiYklP

d2lNdlhoS2h0bmtYcHk5QmRDdXZBZkRuMWRZTXlaY25xX3VGZlpzSWF5VWZSRGhNZzN2cGhOZUtR

SUFSNXg0RUVfWmRfREM1YjhMa2QxTUpiemF3N003VkN1WDhRV2ZwMEFYbW1McUk5bGtDVlN2cGRX

VUFWVDVCZkg4V2NPLVNER19UQms3UWxIYkttbGxjNWhZR0t0czR0NGhzVDBxVXhyYm1jZFlGc2hl

d3J0NDhVRHY1UlEwbGpZZHIwMXZkQ1JfZEZGU21WZWpuaWhtU0diNHYtaFlkM1d5ZU1oZUtCWHVM

Y2R4aEVic1NjSW1kUENteTBTZGpyWHFHQkZFX2dMdElXVE1tYWlDT2NJYUwtWGFjVDloZWNDM2pE

bnIxUTlaZzdranM3aEtpR3dUVTg5YVUtWXBjck9OX2VtVkZRVTRaYTBaZDZxdVB6ZXlsVmpYSnVw

eXZEVVZRZ0Iyb3JSRHdId25yTjlKU1hzcUctcGFqSm9oTk5vS3gwRHI0M2NTd21jTGI2eUxIM29s

b3VuMHVMc25kUlYzV2lNaVlpOUFIR2laTTFJdzdCbUs2SWFXVEd0cVE0Qk55dG9kdy13NFc1NWFt

ckJCTlk2ZkprdENmWHlhekZrSFBTTWh2dllCanBVS29icWlQbnV2N0I1Ni1PcW5iM284NjFoYWQw

YXMweVlLWmlXWDNBSG1TVmNpWlc8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNo

YWlyLmNvbS9laHoyMDYucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0z

WkxfOUNmM3FmS0FjNDg1eXNnQUFBb0F3Z2dKOEJna3Foa2lHOXcwQkJ3YWdnZ0p0TUlJQ2FRSUJB

RENDQW1JR0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTXF0OUk4Mmd2X3IxRjlo

VUVBZ0VRZ0lJQ002SnAxcmxjSE81aGkyN0Z0aXVtZFBoSFdGWDBYNDZGSVUtS2hRTG1FTUh1aERZ

dzZxbDd3R05Wc2k2X2lKMm16N1dhNjhUdHBiZkM2WGM3Z3pJaHpEOFBwNTdFV3k5a3c1Qi0yckNl

dFA3cmVkQ05ORFU5c3NhalY4S3FfcGx4T2FxUk51MVhXRzZMc2hWOXhuZy1sa2VnaXowMHUzbENv

amRhZGVGMjV2UUlaYmJIRGk1ZEthV2xCcmFMMW9EZU0zWWZUajQ0elUzUDk1cTRCOEVTMnp1QjVj

dDJ0UGpDX3pVNHQzbU5nUjVoMmpUakJsQ0twME9PbjlhcXBhSFBNRkZULVRRaVVqMHpzQ3lsVWJZ

MzBXMEU1c09lMUZuaXVzMlR2NEpqLTZHZFdmRmlUZGcxOHU5NXNMUGJoM3h0NC1IbjJXMUtBcTFX

NjF3V2lxcXN2eVVpYjdXYTdBeFZTQnU0Q3dVakdqc0FSXzNvRG9mQ0l5Qm0wUHZDbndhSEU0WHZp

d2lJeHhIdGxVM3hNVHVvbXVidk84QzJtcUVrQ3BTMXpGYUgxOHVaWHNVWDd0Qk1SRk5lclVpQmhk

Zk9rYlM4aGZIVTNJYVhZUXdXSzBZRzBXLTJ1Q0NaeEJVdnR0UW1vUDhwZTlhbndDVVlaeTVaTlRV

YWhaeHRnUE4tVkpScklBT28xZUhGU0w3V0lIZDRKbzdRS2xEbEtYVU44TG02SDBndGpZcXM0R3U0

RnROcG8wYmJPRVZLZ29SM0NaTFhsU1djNERGN3ctbEVJVThPOXZrX29NNTU0UWdrRjNJU2kxSThU

SVNuVFVYOTAwYzc3Um80TmUzZ0l6M3FTeGJNUC1kaTFrdTk2dHcwTDN5ZkZ2alR3blhhLU93cU5p

QTg2SHFhR2pUY0lGT3E3VXc3NUlnQ0JOdVJHLXFyTlpqcDRUVGFiWlQ1VzZ2WEdoTWRyQk5MYVZL

UG5UVVloRG1ZTXRZVWxHVTZCRGR2PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20y

PlBNQzY2ODUzMjg8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVy

aGVhcnRqL2VoejIwNjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE.DATA 8Figure 2. (A) The combined effect of smoking over lifetime and intensity of drinking on arterial stiffness. The combination of high-intensity drinking with lifetime smoking exposure is shown. Pulse wave velocity measurements are expressed as mean values and 95% confidences intervals around the mean on the x-axis. The participants who had ?high‘ drinking intensity and ?high‘ smoking exposure had the highest pulse wave velocity compared with the ?low lifetime smoking exposure‘ and ?low drinking intensity‘. * p<0.05. (B) Unhealthy behaviours in adolescents (drinking and cigarette smoking) are associated with increased carotid to femoral pulse wave velocity (stiffer arteries) and accelerated atherosclerosis. Stopping smoking in adolescents and reducing binge drinking has potential for reversibility of arterial stiffening.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGFyYWtpZGE8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFy

PjxSZWNOdW0+NDA2ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3Jp

cHQiPjEzPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA2ODwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDYwOTU3Ij40MDY4PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DaGFyYWtpZGEsIE0uPC9hdXRob3I+

PGF1dGhvcj5HZW9yZ2lvcG91bG9zLCBHLjwvYXV0aG9yPjxhdXRob3I+RGFuZ2FyZHQsIEYuPC9h

dXRob3I+PGF1dGhvcj5DaGllc2EsIFMuIFQuPC9hdXRob3I+PGF1dGhvcj5IdWdoZXMsIEEuIEQu

PC9hdXRob3I+PGF1dGhvcj5SYXBhbGEsIEEuPC9hdXRob3I+PGF1dGhvcj5EYXZleSBTbWl0aCwg

Ry48L2F1dGhvcj48YXV0aG9yPkxhd2xvciwgRC48L2F1dGhvcj48YXV0aG9yPkZpbmVyLCBOLjwv

YXV0aG9yPjxhdXRob3I+RGVhbmZpZWxkLCBKLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPkluc3RpdHV0ZSBvZiBDYXJkaW92YXNjdWxhciBTY2llbmNl

LCBVbml2ZXJzaXR5IENvbGxlZ2UgTG9uZG9uLCBVSy4mI3hEO0RpdmlzaW9uIG9mIEltYWdpbmcg

U2NpZW5jZXMgJmFtcDsgQmlvbWVkaWNhbCBFbmdpbmVlcmluZywgS2luZyZhcG9zO3MgQ29sbGVn

ZSBMb25kb24sIExhbWJldGggV2luZywgU3QgVGhvbWFzJmFwb3M7IEhvc3BpdGFsLCBVSy4mI3hE

O0RlcGFydG1lbnQgb2YgUGFlZGlhdHJpYyBDbGluaWNhbCBQaHlzaW9sb2d5LiBUaGUgUXVlZW4g

U2lsdmlhIENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCwgR290aGVuYnVyZywgU3dlZGVuLiYjeEQ7

TVJDIEludGVncmF0aXZlIEVwaWRlbWlvbG9neSBVbml0IGF0IHRoZSBVbml2ZXJzaXR5IG9mIEJy

aXN0b2wsIEJyaXN0b2wsIFVLLiYjeEQ7UG9wdWxhdGlvbiBIZWFsdGggU2NpZW5jZSwgQnJpc3Rv

bCBNZWRpY2FsIFNjaG9vbCwgVW5pdmVyc2l0eSBvZiBCcmlzdG9sLCBCcmlzdG9sLCBVSy48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FYXJseSB2YXNjdWxhciBkYW1hZ2UgZnJvbSBzbW9r

aW5nIGFuZCBhbGNvaG9sIGluIHRlZW5hZ2UgeWVhcnM6IHRoZSBBTFNQQUMgc3R1ZHk8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48

cGFnZXM+MzQ1LTM1MzwvcGFnZXM+PHZvbHVtZT40MDwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVy

PjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuIDIxPC9kYXRlPjwv

cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02

NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDE2OTU4MTwvYWNjZXNzaW9uLW51

bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w

dWJtZWQvMzAxNjk1ODE8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNv

bS9laHk1MjQucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNm

M3FmS0FjNDg1eXNnQUFBbjB3Z2dKNUJna3Foa2lHOXcwQkJ3YWdnZ0pxTUlJQ1pnSUJBRENDQWw4

R0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTUZzRHU0SmgyeGM0VUJiX3NBZ0VR

Z0lJQ01FNnRBR1JIekVWVHBkQjdhd2M5Zjg3Y2xyU2RyQWllZW9lSTBCQTNiNnZKV2J6Q1Q1THhy

QXV1YTZtTk9sNkE5TnNMNDZreEJIZHViNVpuMHcxTkUxOVZ2X0JSWUJzTFdwYmFfVklZMFVpdTJC

VTFGcXRqNW50RlhlSWZvYnlsTWFBaG8zNDJLWUtjN2dKbGNHV2IzR3RxbXR4anAzc1lUSUVBclFK

aG0zTS1Zejg0V201dXRLLU9Sdi1lbC1nU3MzSG04TXJpNlc1S0JMNzNjaHYxR0ZVRDg3eHdvSENk

Z0lVcm9QNzVzaFBxcWU2RVFWOXBHZ1RmcEJ3VHFvNUY2dFpnSmhtTmdKclRXOW40R25xTmNPMGhZ

eGNUdnYwTm9LVGZSRkNjUnRnbUJzR09sNHFjaFFURHFOVWZ6ekhWUjY2TjlRODVJc2hVYXlYX2JB

Q1Q0c2lPQjd5cW5NSnlsNktCZF9ZdlJFYU91SzNyZEZDMDZHekRFREZSdU1sMFl3Y3J0VGNWWkJ2

T1NHemZ2dFF5MUJwZDRKdGJNME5kU0JzcFRDYVpiTWVhWTY1MTdsZVZTRjJ2SF9vUnZpbkhLZkRl

V0w4TTVlUUZSZjNfSGdmS0hiZTdyOFNKWmthMkYxSlRlNDhiLVYyWl8wd2MzN0FSMkI4aGZCR0x5

and2a1lma3lSOU82REJkWHEwVndPZkUtSm1lTzVobFZERkRfUjB3UlJGVi1MV3Blc1YxSFcwVFAy

MzMwU0pBbENIdHF1Sm11cUozTDNJRXBoLVhEQ1RWREU3TjZrSkM5ZGV2OTdwRTRybjdmZ0tEemJy

WVpZX1FzUGRMS29SZW1LMkZfLWtwUldIbWVrYWFmU0RwelJFUnlnYkZ4NHdYbkd6cjRrMlNocTdH

SXdXN0FmU2VZZGl2UURhX0tISTYtQWNHblo3OXh6OVI4c25tVTdmZmdyNFN0SGFFS2FfS3F6QTA4

Vl9raWVOMmJnalA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNjM0MDEw

MDwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh5

NTI0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGFyYWtpZGE8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFy

PjxSZWNOdW0+NDA2ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3Jp

cHQiPjEzPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDA2ODwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJlYXAwMmZmanhwemFz

ZXMycjc1MGFkZ2ZmZHZmNXhlZnZwcCIgdGltZXN0YW1wPSIxNTY5MDYwOTU3Ij40MDY4PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DaGFyYWtpZGEsIE0uPC9hdXRob3I+

PGF1dGhvcj5HZW9yZ2lvcG91bG9zLCBHLjwvYXV0aG9yPjxhdXRob3I+RGFuZ2FyZHQsIEYuPC9h

dXRob3I+PGF1dGhvcj5DaGllc2EsIFMuIFQuPC9hdXRob3I+PGF1dGhvcj5IdWdoZXMsIEEuIEQu

PC9hdXRob3I+PGF1dGhvcj5SYXBhbGEsIEEuPC9hdXRob3I+PGF1dGhvcj5EYXZleSBTbWl0aCwg

Ry48L2F1dGhvcj48YXV0aG9yPkxhd2xvciwgRC48L2F1dGhvcj48YXV0aG9yPkZpbmVyLCBOLjwv

YXV0aG9yPjxhdXRob3I+RGVhbmZpZWxkLCBKLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPkluc3RpdHV0ZSBvZiBDYXJkaW92YXNjdWxhciBTY2llbmNl

LCBVbml2ZXJzaXR5IENvbGxlZ2UgTG9uZG9uLCBVSy4mI3hEO0RpdmlzaW9uIG9mIEltYWdpbmcg

U2NpZW5jZXMgJmFtcDsgQmlvbWVkaWNhbCBFbmdpbmVlcmluZywgS2luZyZhcG9zO3MgQ29sbGVn

ZSBMb25kb24sIExhbWJldGggV2luZywgU3QgVGhvbWFzJmFwb3M7IEhvc3BpdGFsLCBVSy4mI3hE

O0RlcGFydG1lbnQgb2YgUGFlZGlhdHJpYyBDbGluaWNhbCBQaHlzaW9sb2d5LiBUaGUgUXVlZW4g

U2lsdmlhIENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCwgR290aGVuYnVyZywgU3dlZGVuLiYjeEQ7

TVJDIEludGVncmF0aXZlIEVwaWRlbWlvbG9neSBVbml0IGF0IHRoZSBVbml2ZXJzaXR5IG9mIEJy

aXN0b2wsIEJyaXN0b2wsIFVLLiYjeEQ7UG9wdWxhdGlvbiBIZWFsdGggU2NpZW5jZSwgQnJpc3Rv

bCBNZWRpY2FsIFNjaG9vbCwgVW5pdmVyc2l0eSBvZiBCcmlzdG9sLCBCcmlzdG9sLCBVSy48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FYXJseSB2YXNjdWxhciBkYW1hZ2UgZnJvbSBzbW9r

aW5nIGFuZCBhbGNvaG9sIGluIHRlZW5hZ2UgeWVhcnM6IHRoZSBBTFNQQUMgc3R1ZHk8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48

cGFnZXM+MzQ1LTM1MzwvcGFnZXM+PHZvbHVtZT40MDwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVy

PjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuIDIxPC9kYXRlPjwv

cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5NS02

NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDE2OTU4MTwvYWNjZXNzaW9uLW51

bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w

dWJtZWQvMzAxNjk1ODE8L3VybD48dXJsPmh0dHBzOi8vd2F0ZXJtYXJrLnNpbHZlcmNoYWlyLmNv

bS9laHk1MjQucGRmP3Rva2VuPUFRRUNBSGkyMDhCRTQ5T29hbjlra2hXX0VyY3k3RG0zWkxfOUNm

M3FmS0FjNDg1eXNnQUFBbjB3Z2dKNUJna3Foa2lHOXcwQkJ3YWdnZ0pxTUlJQ1pnSUJBRENDQWw4

R0NTcUdTSWIzRFFFSEFUQWVCZ2xnaGtnQlpRTUVBUzR3RVFRTUZzRHU0SmgyeGM0VUJiX3NBZ0VR

Z0lJQ01FNnRBR1JIekVWVHBkQjdhd2M5Zjg3Y2xyU2RyQWllZW9lSTBCQTNiNnZKV2J6Q1Q1THhy

QXV1YTZtTk9sNkE5TnNMNDZreEJIZHViNVpuMHcxTkUxOVZ2X0JSWUJzTFdwYmFfVklZMFVpdTJC

VTFGcXRqNW50RlhlSWZvYnlsTWFBaG8zNDJLWUtjN2dKbGNHV2IzR3RxbXR4anAzc1lUSUVBclFK

aG0zTS1Zejg0V201dXRLLU9Sdi1lbC1nU3MzSG04TXJpNlc1S0JMNzNjaHYxR0ZVRDg3eHdvSENk

Z0lVcm9QNzVzaFBxcWU2RVFWOXBHZ1RmcEJ3VHFvNUY2dFpnSmhtTmdKclRXOW40R25xTmNPMGhZ

eGNUdnYwTm9LVGZSRkNjUnRnbUJzR09sNHFjaFFURHFOVWZ6ekhWUjY2TjlRODVJc2hVYXlYX2JB

Q1Q0c2lPQjd5cW5NSnlsNktCZF9ZdlJFYU91SzNyZEZDMDZHekRFREZSdU1sMFl3Y3J0VGNWWkJ2

T1NHemZ2dFF5MUJwZDRKdGJNME5kU0JzcFRDYVpiTWVhWTY1MTdsZVZTRjJ2SF9vUnZpbkhLZkRl

V0w4TTVlUUZSZjNfSGdmS0hiZTdyOFNKWmthMkYxSlRlNDhiLVYyWl8wd2MzN0FSMkI4aGZCR0x5

and2a1lma3lSOU82REJkWHEwVndPZkUtSm1lTzVobFZERkRfUjB3UlJGVi1MV3Blc1YxSFcwVFAy

MzMwU0pBbENIdHF1Sm11cUozTDNJRXBoLVhEQ1RWREU3TjZrSkM5ZGV2OTdwRTRybjdmZ0tEemJy

WVpZX1FzUGRMS29SZW1LMkZfLWtwUldIbWVrYWFmU0RwelJFUnlnYkZ4NHdYbkd6cjRrMlNocTdH

SXdXN0FmU2VZZGl2UURhX0tISTYtQWNHblo3OXh6OVI4c25tVTdmZmdyNFN0SGFFS2FfS3F6QTA4

Vl9raWVOMmJnalA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNjM0MDEw

MDwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9ldXJoZWFydGovZWh5

NTI0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 13Figure 3. Long-term mortality after use of paclitaxel-based devices in LEAD. A multivariable Cox regression analysis was developed including numerous comorbidities and all devices that were applied in each treated patient. For each distinct device, the analysis accounted for its type (DES, DCB, BMS, and POBA) and application date. The model took also concern of any non-constant time-dependent effects: thus, a potentially detrimental effect of DED in the later course of time would become verifiable despite a potentially beneficial effect in the early years, or also any potential aggregation of subsequently applied devices. Combined HRs for any scenario including multiple devices that were applied various years ago can be determined as the product of elementary HRs. In summary, there was no signal that paclitaxel DCBs or DES were associated with increased mortality up to 11 years of Follow-up. ADDIN EN.CITE <EndNote><Cite><Author>Freisinger</Author><Year>2019</Year><RecNum>4122</RecNum><DisplayText><style face="superscript">29</style></DisplayText><record><rec-number>4122</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1570194406">4122</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Freisinger, E.</author><author>Koeppe, J.</author><author>Gerss, J.</author><author>Goerlich, D.</author><author>Malyar, NM.</author><author>Marschall, U.</author><author>Faldum, A.</author><author>Reinecke, H.</author></authors></contributors><titles><title>Mortality after use of paclitaxel-based devices in peripheral arteries: a real-world safety analysis</title><secondary-title>Eur Heart J</secondary-title></titles><volume>Epub ahead of print</volume><dates><year>2019</year></dates><urls></urls></record></Cite></EndNote>29 Figure 4. New imaging techniques for risk stratification in patients with aortic diseases (A) Methods for proximal longitudinal strain measurement by MRI,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdWFsYTwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MTA4PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

MzM8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA4PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc3NTQiPjQxMDg8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkd1YWxhLCBBLjwvYXV0aG9yPjxhdXRob3I+

VGVpeGlkby1UdXJhLCBHLjwvYXV0aG9yPjxhdXRob3I+Um9kcmlndWV6LVBhbG9tYXJlcywgSi48

L2F1dGhvcj48YXV0aG9yPlJ1aXotTXVub3osIEEuPC9hdXRob3I+PGF1dGhvcj5EdXgtU2FudG95

LCBMLjwvYXV0aG9yPjxhdXRob3I+VmlsbGFsdmEsIE4uPC9hdXRob3I+PGF1dGhvcj5HcmFuYXRv

LCBDLjwvYXV0aG9yPjxhdXRob3I+R2FsaWFuLCBMLjwvYXV0aG9yPjxhdXRob3I+R3V0aWVycmV6

LCBMLjwvYXV0aG9yPjxhdXRob3I+R29uemFsZXotQWx1amFzLCBULjwvYXV0aG9yPjxhdXRob3I+

U2FuY2hleiwgVi48L2F1dGhvcj48YXV0aG9yPkZvcnRlemEsIEEuPC9hdXRob3I+PGF1dGhvcj5H

YXJjaWEtRG9yYWRvLCBELjwvYXV0aG9yPjxhdXRob3I+RXZhbmdlbGlzdGEsIEEuPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJk

aW9sb2d5LCBIb3NwaXRhbCBVbml2ZXJzaXRhcmkgVmFsbCBkJmFwb3M7SGVicm9uLCBDSUJFUi1D

ViwgVmFsbCBkJmFwb3M7SGVicm9uIGluc3RpdHV0IGRlIFJlY2VyY2EsIFVuaXZlcnNpdGF0IEF1

dG9ub21hIGRlIEJhcmNlbG9uYSwgUGFzZW8gVmFsbCBkJmFwb3M7SGVicm9uIDExOS0xMjksIEJh

cmNlbG9uYSwgU3BhaW4uJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIEhvc3BpdGFsIGRv

Y2UgZGUgT2N0dWJyZSwgQXZlbmlkYSBDb3Jkb2JhLCBNYWRyaWQsIFNwYWluLiYjeEQ7RGVwYXJ0

bWVudCBvZiBDYXJkaWFjIFN1cmdlcnksIEhvc3BpdGFsIFB1ZXJ0YSBkZSBIaWVycm8uIENhbGxl

IE1hbnVlbCBkZSBGYWxsYSwgMSwgTWFqYWRhaG9uZGEsIFNwYWluLjwvYXV0aC1hZGRyZXNzPjx0

aXRsZXM+PHRpdGxlPlByb3hpbWFsIGFvcnRhIGxvbmdpdHVkaW5hbCBzdHJhaW4gcHJlZGljdHMg

YW9ydGljIHJvb3QgZGlsYXRpb24gcmF0ZSBhbmQgYW9ydGljIGV2ZW50cyBpbiBNYXJmYW4gc3lu

ZHJvbWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+MjA0Ny0yMDU1PC9wYWdlcz48dm9sdW1lPjQwPC92b2x1bWU+PG51

bWJlcj4yNTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Bb3J0aWMgZGlsYXRpb248L2tleXdv

cmQ+PGtleXdvcmQ+QW9ydGljIHN0cmFpbjwva2V5d29yZD48a2V5d29yZD5Mb25naXR1ZGluYWwg

c3RyYWluPC9rZXl3b3JkPjxrZXl3b3JkPk1hcmZhbiBzeW5kcm9tZTwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsIDE8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1

LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMwOTc3NzgzPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8zMDk3Nzc4MzwvdXJsPjx1cmw+aHR0cHM6Ly9hY2FkZW1pYy5vdXAuY29tL2V1cmhl

YXJ0ai9hcnRpY2xlLWFic3RyYWN0LzQwLzI1LzIwNDcvNTQ0ODg4MT9yZWRpcmVjdGVkRnJvbT1m

dWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTA5My9ldXJoZWFydGovZWh6MTkxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3Jl

Y29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdWFsYTwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+PFJl

Y051bT40MTA4PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

MzM8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40MTA4PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMmVhcDAyZmZqeHB6YXNlczJy

NzUwYWRnZmZkdmY1eGVmdnBwIiB0aW1lc3RhbXA9IjE1Njk5Mzc3NTQiPjQxMDg8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkd1YWxhLCBBLjwvYXV0aG9yPjxhdXRob3I+

VGVpeGlkby1UdXJhLCBHLjwvYXV0aG9yPjxhdXRob3I+Um9kcmlndWV6LVBhbG9tYXJlcywgSi48

L2F1dGhvcj48YXV0aG9yPlJ1aXotTXVub3osIEEuPC9hdXRob3I+PGF1dGhvcj5EdXgtU2FudG95

LCBMLjwvYXV0aG9yPjxhdXRob3I+VmlsbGFsdmEsIE4uPC9hdXRob3I+PGF1dGhvcj5HcmFuYXRv

LCBDLjwvYXV0aG9yPjxhdXRob3I+R2FsaWFuLCBMLjwvYXV0aG9yPjxhdXRob3I+R3V0aWVycmV6

LCBMLjwvYXV0aG9yPjxhdXRob3I+R29uemFsZXotQWx1amFzLCBULjwvYXV0aG9yPjxhdXRob3I+

U2FuY2hleiwgVi48L2F1dGhvcj48YXV0aG9yPkZvcnRlemEsIEEuPC9hdXRob3I+PGF1dGhvcj5H

YXJjaWEtRG9yYWRvLCBELjwvYXV0aG9yPjxhdXRob3I+RXZhbmdlbGlzdGEsIEEuPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJk

aW9sb2d5LCBIb3NwaXRhbCBVbml2ZXJzaXRhcmkgVmFsbCBkJmFwb3M7SGVicm9uLCBDSUJFUi1D

ViwgVmFsbCBkJmFwb3M7SGVicm9uIGluc3RpdHV0IGRlIFJlY2VyY2EsIFVuaXZlcnNpdGF0IEF1

dG9ub21hIGRlIEJhcmNlbG9uYSwgUGFzZW8gVmFsbCBkJmFwb3M7SGVicm9uIDExOS0xMjksIEJh

cmNlbG9uYSwgU3BhaW4uJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIEhvc3BpdGFsIGRv

Y2UgZGUgT2N0dWJyZSwgQXZlbmlkYSBDb3Jkb2JhLCBNYWRyaWQsIFNwYWluLiYjeEQ7RGVwYXJ0

bWVudCBvZiBDYXJkaWFjIFN1cmdlcnksIEhvc3BpdGFsIFB1ZXJ0YSBkZSBIaWVycm8uIENhbGxl

IE1hbnVlbCBkZSBGYWxsYSwgMSwgTWFqYWRhaG9uZGEsIFNwYWluLjwvYXV0aC1hZGRyZXNzPjx0

aXRsZXM+PHRpdGxlPlByb3hpbWFsIGFvcnRhIGxvbmdpdHVkaW5hbCBzdHJhaW4gcHJlZGljdHMg

YW9ydGljIHJvb3QgZGlsYXRpb24gcmF0ZSBhbmQgYW9ydGljIGV2ZW50cyBpbiBNYXJmYW4gc3lu

ZHJvbWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEhlYXJ0IEo8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGFnZXM+MjA0Ny0yMDU1PC9wYWdlcz48dm9sdW1lPjQwPC92b2x1bWU+PG51

bWJlcj4yNTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Bb3J0aWMgZGlsYXRpb248L2tleXdv

cmQ+PGtleXdvcmQ+QW9ydGljIHN0cmFpbjwva2V5d29yZD48a2V5d29yZD5Mb25naXR1ZGluYWwg

c3RyYWluPC9rZXl3b3JkPjxrZXl3b3JkPk1hcmZhbiBzeW5kcm9tZTwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsIDE8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTIyLTk2NDUgKEVsZWN0cm9uaWMpJiN4RDswMTk1

LTY2OFggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjMwOTc3NzgzPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8zMDk3Nzc4MzwvdXJsPjx1cmw+aHR0cHM6Ly9hY2FkZW1pYy5vdXAuY29tL2V1cmhl

YXJ0ai9hcnRpY2xlLWFic3RyYWN0LzQwLzI1LzIwNDcvNTQ0ODg4MT9yZWRpcmVjdGVkRnJvbT1m

dWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTA5My9ldXJoZWFydGovZWh6MTkxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3Jl

Y29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 33 (B) Doppler approach to flow in aortic dissection ADDIN EN.CITE <EndNote><Cite><Author>Desai</Author><Year>2019</Year><RecNum>4092</RecNum><DisplayText><style face="superscript">35</style></DisplayText><record><rec-number>4092</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1569929744">4092</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Desai, D.</author><author>Miranda, W.</author><author>Connolly, H.</author><author>Tajik, A. J.</author></authors></contributors><auth-address>Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke&apos;s Medical Centers, University of Wisconsin School of Medicine and Public Health, 2801 W. Kinnickinnic River Parkway, Ste 840, Milwaukee, WI, USA.&#xD;Department of Cardiovascular Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.</auth-address><titles><title>Flow dynamics in the false lumen in distal aorta following surgery for type A aortic dissection</title><secondary-title>Eur Heart J</secondary-title></titles><pages>561</pages><volume>40</volume><number>6</number><dates><year>2019</year><pub-dates><date>Feb 7</date></pub-dates></dates><isbn>1522-9645 (Electronic)&#xD;0195-668X (Linking)</isbn><accession-num>30085046</accession-num><urls><related-urls><url> 5. Pulmonary embolism management algorithm. ADDIN EN.CITE <EndNote><Cite><Author>Torbicki</Author><Year>2019</Year><RecNum>4097</RecNum><DisplayText><style face="superscript">48</style></DisplayText><record><rec-number>4097</rec-number><foreign-keys><key app="EN" db-id="2eap02ffjxpzases2r750adgffdvf5xefvpp" timestamp="1569936726">4097</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Torbicki, A.</author></authors></contributors><auth-address>Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Center for Postgraduate Medical Education, ECZ-Otwock, Otwock, Poland.</auth-address><titles><title>Assessing the severity of acute pulmonary embolism: back to the future?</title><secondary-title>Eur Heart J</secondary-title></titles><pages>911-913</pages><volume>40</volume><number>11</number><dates><year>2019</year><pub-dates><date>Mar 14</date></pub-dates></dates><isbn>1522-9645 (Electronic)&#xD;0195-668X (Linking)</isbn><accession-num>30726904</accession-num><urls><related-urls><url> Figure 1Figure 2Figure 3Figure 4 Figure 5 ................
................