This is the control pathway for estrogen:



Anatomy: On the torso models, identify the gland that is secreting each hormone below.

Endocrine control: This is the negative feedback reflex loop for cortisol regulation.

CRH

( + -

ACTH

( + -

cortisol

1. CRH is an abbreviation for ____________________________.

2. CRH is secreted from which organ? ________________________

3. Is CRH a peptide, steroid, or amine?

4. What organ has cells with receptors for CRH?

5. What kind of receptor does CRH activate? intracellular or membrane-bound

6. When CRH binds to its receptors and initiates a response from a cell, what is the response (what is the end result)?

7. ACTH is an abbreviation for _______________________________.

8. How is ACTH stored in anterior pituitary cells before release? (hint: see text Fig. 7-3)

9. What organ has cells with receptors for ACTH?

10. Cortisol is a chemical made from ___________________.

11. Note that the control pathway above is incomplete in that it doesn’t include the target tissue for cortisol. Name an organ or tissue with receptors for cortisol.

12. Are cortisol receptors membrane or intracellular receptors?

13. What does cortisol do? What is its function?

14. If cortisol levels are very high due to a pituitary tumor, will CRH levels be high, low or no change?

(To try later: Answer these questions for other hypothalamic/anterior pituitary/end organ hormones.)

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