BRO-ZEDEX RANGE Knowledge Express - Wockhardt -Login

[Pages:7]BRO-ZEDEX RANGE Knowledge Express

Composition:

Bro Zedex ? Terbutaline Sulphate 1.25mg + Bromhexine HCL 4 mg + Guaiphenesin 50 mg + Menthol 2.5mg/5ml

Bro Zedex SF - Terbutaline Sulphate 1.25mg + Bromhexine HCL 4 mg + Guaiphenesin 50 mg + Menthol 2.5mg/5ml (Sugar Free Base of Sucralose)

Bro Zedex LS Kid: Levosalbutamol Sulphate 1 mg + Ambroxol HCL 30 mg + Guaiphenesin 50 mg + mentholated base /5ml

Bro Zedex LS Plus: Levosalbutamol Sulphate 1 mg + Ambroxol HCL 30 mg + Guaiphenesin 50 mg + Mentholated sugar free base /5ml (Sugar Free Base of Sucralose)

Brozedex LS drops: Levosalbutamol Sulphate 0.25 mg + Ambroxol HCL7.5mg + Guaiphenesin 12.5mg /ml

Indication:

Composition Bro Zedex Bro Zedex SF

Bro Zedex LS Kid

Bro Zedex LS+

Brozedex LS drops

Indication

Productive Cough

Productive Cough in Diabetic Patients Bronchospastic Cough in Children associated with acute bronchitis and bronchial asthma Chronic Respiratory Conditions in elderly like COPD , Asthma , Bronchitis with comorbidity Wheezing and chest congestion in kids associated with bronchitis , bronchial asthma

Dose:

SR.NO 1

BRAND Bro ?Zedex

COMPOSITION / 5ml

Terbutaline Sulphate 1.25mg + Bromhexine HCL 4 mg + Guaiphenesin 50 mg + Menthol 2.5mg/5ml

INDICATION/POSITIONING

Moderate-Severe Productive/Bronchospastic cough

AGE GROUP & DOSING

Adults -10ml 2-3 times/day

6-12 years 5 ml TID

3 ? 6 years 2.5 ml TID

2 to 6 years 2.5 ml BID

6 ? 12 years: start with 2.5

ml thrice daily

Levosalbutamol

and increase to

Sulphate 1 mg +

5 ml of syrup 2-

Ambroxol HCL 30

3 times daily.

2

Brozedex LS kid

mg + Guaiphenesin 50 mg + Menthol 0.8 mg

Moderate-Severe Bronchospastic/Productive cough

in kids

Adults (>12 years) : 5ml

Expectorant/5ml

three times

daily. This may

be increased to

10 ml syrup

twice daily.

Adults (>12

Levosalbutamol Sulphate 1 mg +

years) : 5ml three times

3

Brozedex LS Plus

Ambroxol HCL 30 mg + Guaiphenesin 50 mg + Menthol

0.1 mg

Chronic Respiratory Conditions in elderly like COPD , Asthma , Bronchitis with co-morbidity

daily. This may be increased to 10 ml syrup

Expectorant/5ml (Sugar Free Base)

twice daily.

4

Brozedex LS drops

Levosalbutamol Sulphate 0.25 mg + Ambroxol

Wheezing and chest congestion in kids associated with bronchitis ,

bronchial asthma

2ml three times daily.

HCL7.5mg + Guaiphenesin 12.5mg /ml

Key Message:

Bro-Zedex

Nair Hospital Mumbai confirms that Brozedex is most viscous compared to other leading brands.

Bro Zedex is 100% more viscous compared to leading brands like Ascoril . Brozedex offers faster symptomatic relief in 30 mins Terbutaline in Brozedex relaxes airway muscles , improves pulmonary function & breathing Bromhexine in Brozedex is a mucolytic agent with antioxidant properties Guaiphenesin in Brozedex improves expectoration Menthol in Brozedex offers cooling soothing effect. Brozedex is celebrating 26 years of freedom to express in productive cough associated LRTI

and AECB Hence in productive cough Brozedex offers freedom from cough for last 26 years

Brozedex SF

Studies have shown that cough syrups contain substantial amount of sugar. Department of Clinical Pharmacology, Nair Hospital confirms, most commonly preferred brands like Asco, Gri_Lt, Or Bro-Zit, contains on an average 3 tsp sugar per 30 ml of syrup (per day dose) ie 48 gram sugar / 100 ml of conventional cough syrup.

Also conventional cough syrup contains 4 times more sugar then a cold drink ( 12 gm / 100 ml of sugar in cold drink versus 48 gm/ 100 ml of cough syrup ).

Therefore in diabetic and hypertensive patients, when every spoon of sugar counts, Brozedex SF is an ideal choice as it is available in sugar free form.

Bro Zedex LS Kid

Brozedex LS Kid in Bronchospatic cough, is the 1st Levosalbutamol syrup with calibrated patented spoon ie Brozedex LS Kid is exclusively designed to offer dosing convenience; accuracy and contamination free dosing tool to help mothers which is alo published in the form of CAPCON study in Indian Journal of Clinical Practise July 2015.

Brozedex LS kid has 1 mg of levosalbutmol with better bronchodilation & safety profile compared to salbutamol

Brozedex LS kid reduces need of nebulization& concomitant medication and has 95% more treatment satisfaction rates compared to salbutamol

 Brozedex LS kid formulation is DCGI approved with patented calibrated spoon that provides hygienic and accurate dosing to your patients

Bro Zedex LS+

? In chronic respiratory condition like Asthma , Bronchitis , COPD recommend Brozedex L S Plus which is the only sugar free form of Levosalbutamol combination available in India

? Brozedex LS Plus offers superior tolerability and safety compared to Salbutamol ? Brozedex LS Plus is an effective bronchodilator compared to Salbutamol ? Brozedex LS Plus formulation is DCGI approved with sugar free form , yet sweet

to taste . ? RX Brozedex LS Plus that offers sugar free safety , superior tolerability and

efficacy of levosalbutamol combination in chronic respiratory condition like Asthma , Bronchitis , COPD

Brozedex LS drops

Wheezing & chest congestion limits the expression of childhood, Brozedex LS drops offers cough relief for lasting smiles

Brozedex LS drops has 0.25 mg of levosalbutmol with better bronchodilation & safety profile compared to salbutamol

7.5mg of Ambroxol in Brozedex LS drops reduces sputum volume & viscosity 12.5 mg Guaiphenesin in Brozedex LS drops improves expectoration Brozedex LS drops comes along with a scientifically calibrated dropper for dosage accuracy .

Calibration in dropper of Brozedex LS drops starts from 0.1 ml to 1 ml . Rx Brozedex LS drops for cough relief with lasting smiles

Ingredient Guaiphenesin

Terbutaline Levosalbutamol

Pedia dose

Adult dose

Reference

2-6 years: 50 to 100 mg

orally every 4 hours; maximum 600 mg/day

6-12 years: 100 to 200 mg orally every 4 hours; maximum 1200 mg/day

12 years & above: 200 to 400 mg orally every 4 hours; maximum 2400 mg/day

Micromedex.

Along with terbutaline / levosalbutamol the Guaiphenesin requirement can correspondingly be reduced.

2.5 to 5 mg ORALLY every 6 hr 3 times daily, MAX 15 mg/day

50% of Salbutamol dosage

50% of Salbutamol dosage given 2 to 3 times daily.

0.05 mg to 0.2mg/kg/dose every 8 hour oral

As per text book Drug Dosages in Children, 8th ED ;Meharban Singh and Asok Deorari

Bromhexine Ambroxol

2-4 mg three times daily 8 to 16 milligrams orally

below 5 years of age

three times daily.

Micromedex

4 mg twice daily for

30 milligrams twice

children under 5 years of daily alternatively

age

4 mg four times daily for children 5 to 10 years of age

Up to 2 years - 15 milligrams (mg) daily;

2 to 5 years - 15 to 30 mg daily;

5 to 12 years - 30 to 45 mg daily

12 years and older - 60 to 90 mg daily

Oral adult doses of 60 to 180 milligrams/day in 2 or 3 divided doses. Average 120 mg/day.

Micromedex

Many doctors feel that the dosing of Ambroxol in this combination is on the higher side but as children are poor at expectorating sputum, additional

mucolytic support and dosing strength is now being widely accepted instead of a higher dosing strength of expectorant.

Competitor Knock out points :

Sr Brand no

Company Knock out point

1 Ascoril

Glenmark

- Sub therapeutic dose of Bromhexine of 2 mg / 5ml leads to compromised results.

- Micromedex recommends 8 to 16 mg TID of Bromhexine in adults and

- 4 mg twice daily for children under 5 years of age

- Menthol is only 0.5 mg / 5ml this may not lead to cooling soothing effect

- Viscosity of Ascoril is only 50.55centipoise compared to 144 centipoise of Brozedex

2 Ascoril LS

Glenmark

3 Brozeet LS

Alembic

- Very poor taste leads to non-compliance in Little ones

- Conventional method of dosage administration with caps leads to unhygienic and inaccurate dosing in little patients and is proven in CAPCON study publishes in IJCP ( Indian Journal of Clinical Practice )July 2015

- 0.5 mg of Levosalbutamol is not approved by DCGI

- Pineapple flavor has lot of after taste which leads to poor patient compliance

4 Brozeet LS Plus Alembic

5 Kufril LS drops Med manor

6 Kofarest PD drops

Centaur

- Very poor taste leads to non-compliance in patients

- Does not have sugar free formulae as 48 gm of sugar is there / 100 ml which may add complication in patients with co-morbidities associated with Asthma , COPD & Bronchitis

- Does not have accurately calibrated dropper ; calibration starts with 0.25 mg which may lead to inaccuracy of dosage administration

- Does not have accurately calibrated dropper ; calibration is not visible clearly which may mislead the patients / care takers

Pack/ MRP / NSV and Competition

Sr. Name of the No SKU

1

Brozedex

MRP in Rs.

82

NSV in Rs.

58.57

Pack

100 ml bottle

2

Brozedex SF

78.5

3

Brozedex LS kid

74.5

56.07 53.21

100 ml bottle

60 ml bottle

4 Brozedex LS Plus

88

60.34

100 ml bottle

5 Brozedex LS drops

15 ml

41

28.56 bottle

Competitor brand

Company

Ascoril Brozeet Macberry XT Soventus Tus Q X

Glenmark Alembic Macleods Emcure Blue cross

Ascoril SF Brozeet SF

Glenmark Alembic

Ascoril LS Brozeet LS Macberry Junior Chericof LS

Kufril LS

Glenmark Alembic Macleods

Sun Med manor

Ascoril LS Brozeet LS Plus Macberry LS Chericof LS Kufril LS

Glenmark Alembic Macleods Sun Med manor

Ascoril LS drops Kufril LS drops Kofarest PD drops

Glenmark Med manor Centaur

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