Bio-Bibliography
Bio-BibliographyUniversity of California, Santa Cruz, CAGRANT A. HARTZOGProfessor of Molecular, Cell & Developmental BiologyEMPLOYMENT2018Associate Dean, Physical and Biological Sciences, University of California, Santa Cruz2009Professor of MCD Biology, University of California, Santa Cruz2004-2009Associate Professor of MCD Biology, University of California, Santa Cruz1998-2004Assistant Professor of MCD Biology, University of California, Santa Cruz 1992-98Postdoctoral Fellow, Laboratory of Fred Winston, Harvard Medical SchoolEDUCATION1986-92University of California, San Francisco Ph.D., Biochemistry and Biophysics1984-86University of California, San Francisco, Medical Student1984University of California, Berkeley, BA, BiophysicsHONORS AWARDS AND GRANTS2019-23NSF grant, Recruiting and Preparing STEM Teachers for High-Need Schools: Community College-University of California, Santa Cruz Partnerships (Co-PI with Gretchen Andreasen, Debra Lewis, Patricia Stoddart, David Belanger;$1.45M)2018-21NSF-MRI: Development of a Multifocus Structured Illumination Microscope (Co-PI with Sara Abrahmmson, Hinrich Boeger, Needhi Bhalla, Bill Sullivan; $1M)2016UCSC Disciplinary Communication Grant (from the VPDUE, Heather Shearer Co-PI)2014Academic Senate Committee on Research Special Research Grant (Grant Hartzog, Hinrich Boeger and Holger Schmidt, Co-PIs) $80002014NSF Noyce grant, Recruiting and Preparing STEM Teachers for High-NeedSchools: Community College-University of California, Santa Cruz Partnerships (Co-PI with Gretchen Andreasen, Debra Lewis, Patricia Stoddart, David Belanger; $1.45M)2013-19NSF grant, Investigation of the Causal Relationship Between Chromatin Structure Fluctuations and Gene Expression Noise by Electron and Fluorescence Microscopy (Co-PI with Hinrich Boeger; $902,588)2012-16NIH grant, (I was a subcontractor on this proposal, the PI is my collaborator, Jianhua Fu, Medical College of Wisconsin; ~$29,271/yr in direct costs to UCSC)2012Santa Cruz Cancer Benefit Group, $15,0002008Academic Senate Committee on Research Special Research Grant $8,0002006Supplement to NIH RO1 for training under-represented minority student: $33,8352005-9NIH RO1 23866-443656: current direct costs $176,0002002-2003Cancer Research Coordinating Committee: Direct Costs $50,0002002Non-tenured faculty development award $5,0002002Voted instructor of the year by graduating seniors in Biology.2001Nominated for Committee on Teaching’s Excellence in Teaching Award2001Keck Foundation Mass Spectrometry Instrumentation Grant: (Co-PI; $1M)2001Microarray supplement to NIH R01 ($35,000)2000-2001Non-tenured faculty development award ($5,000)1999-2004 NIH R01 23866-443656: Total Direct Costs ($770,354)1999-2000Cancer Research Coordinating Committee: Direct Costs ($40,000)1999-2000Non-tenured faculty development award ($4,900)1995-98Medical Foundation/Charles A. King Trust Postdoctoral Fellow1992-95NIH NRSA Postdoctoral Fellowship1984ARCS Foundation Scholar1983-84Highest Honors in Biophysics and Highest University HonorsPresident’s Undergraduate Scholarship, University of California, Berkeley1983Phi Beta KappaPUBLICATIONSPapers Published or In Press Hanauer D., et al.,?An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning.?Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13531-13536.Blythe AJ, Yazar-Klosinski B, Webster MW, Chen E, Vandevenne M, Bendak K, Mackay JP, Hartzog GA, Vrielink A.nThe yeast transcription elongation factor Spt4/5 is a sequence-specific RNA binding protein. Protein Sci. 2016 Sep;25(9):1710-21. doi: 10.1002/pro.2976. Meyer, P.A., Li S., Zhang, M., Yamada, K. Takagi, Y., Hartzog, G.A. and J. Fu, Structures and functions of the multiple KOW domains of transcription elongation factor Spt5. Mol. Cell. Biol. 2015 Oct; 35(19)3354-69. doi:10.1128/MCB.00520-15.Pope W, et al., Whole genome comparison of a large group of mycobacteriophages reveals a continuum of phage genetic diversity. Elife. 2015 Apr 28;4:e06416. doi: 10.7554/eLife.06416.Cresawn SG, et al., Comparitive Genomics of Cluster O Mycobacteriophages. PLoS One. 2015 Mar 5;10(3):e0118725. doi: 10.1371/journal.pone.0118725. eCollection 2015.Blythe A, Gunasekara S, Walshe J, Mackay JP, Hartzog GA, Vrielink A., Ubiquitin fusion constructs allow the expression and purification of multi-KOW domain complexes of the Saccharomyces cerevisiae transcription elongation factor Spt4/5. Protein Expr Purif. 2014 Aug;100:54-60. doi: 10.1016/j.pep.2014.05.005.Dustin A. Wride, Nader Pourmand, Walter M. Bray, Jacob J. Kosarchuk, Sean C. Nisam,Tiffani K. Quan, Ray F. Berkeley, Sol Katzman, Grant A. Hartzog, Carlos E. Dobkin, R. ScottLokey. Confirmation of the cellular targets of benomyl and rapamycin usingnext-generation sequencing of resistant mutants in S. cerevisiae. Molecular BioSystems, 2014, DOI: 10.1039/C4MB00146JHartzog GA, Fu J. The Spt4-Spt5 complex: a multi-faceted regulator of transcription elongation.Biochim Biophys Acta. 2013 Jan;1829(1):105-15. PMID: 22982195 (invited review)Jordan TC, et al. A Broadly Implementable Research Course in Phage Discovery and Genomics for First-Year Undergraduate Students. mBio. 2014, 5(1):e01051-13Pope WH et al., Cluster M mycobacteriophages Bongo, PegLeg, and Rey with unusually large repertoires of tRNA isotypes. J Virol. 2014, 88(5):2461-80.Radman-Livaja M, Quan TK, Valenzuela L, Armstrong JA, van Welsem T, Kim T, Lee LJ, Buratowski S, van Leeuwen F, Rando OJ, Hartzog GA. A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast. PLoS Genet. 2012;8(7):e1002811. doi:10.1371/journal.pgen.1002811. Epub 2012 Jul 12. PMID: 22807688Zuckerman NB, Myers AS, Quan TK, Bray WM, Lokey RS, Hartzog GA, Konopelski JP. Structural determination of NSC 670224, synthesis of analogues and biological evaluation. ChemMedChem. 2012 May;7(5):761-5. doi: 10.1002/cmdc.201200038. Epub 2012 Feb 29.PMID: 22378491Pope WH, et al., Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution. PLoS ONE, 2011; 6(1):e16329.Quan T.K., Hartzog G.A.. Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription. Genetics, 2010, 184: 321-334.Min Guo, Fei Xu, Jena Yamada, Thea Egelhofer, Yongxiang Gao, Grant A. Hartzog, Maikun Teng, Liwen Niu. Core Structure of the yeast Spt4-Spt5 Complex: A Conserved Module for Regulation of Transcription Elongation. Structure, 2008, 16(11):1649-58.Yuanyuan Xiao, Yee H Yang, Todd A Burckin, Lily Shiue, Grant A Hartzog and Mark R Segal. Analysis of a Splice Array Experiment Elucidates Roles of Chromatin Elongation Factor Spt4-5 in Splicing. PLOS Computational Biology, 2005, 1(4): e39.Todd Burckin, Roland Nagel, Yael Mandel-Gutfreund, Lily Shiue, Tyson A. Clark, Jean-Leon Chong Tien-Hsien Chang, Sharon Squazzo, Grant Hartzog and Manuel Ares, Jr. Exploring functional relationships between components of the transcription, splicing, and mRNA export machineries by gene expression phenotype analysis. Nature Structural and Molecular Biology, 12(2):175-82 (2005).Simic R., Lindstrom D.L., Tran H.G., Roinick K.L., Costa P.J., Johnson A.D., Hartzog G.A., Arndt K.M. The Saccharomyces cerevisiae chromatin-modifying protein Chd1 localizes to the transcribed regions of genes and interacts with transcription elongation factors. EMBO J. 22(8): 1846-1856 (2003).Lindstrom D.L., Squazzo S., Mustser N., Burckin T., Wachter K., Emigh C., McCleery J., Yates J., Hartzog G.A. 2003. The Spt4-Spt5 complex associates with multiple protein complexes invovled in transcription elongation and pre-mRNA processing. Molecular and Cellular Biology 23(4):1368-78.Squazzo S., Costa P.J., Lindstrom D.L., Kumer K.E., Simic R., Jennings J.L., Link A.J., Arndt K.M., Hartzog G.A. 2002 .The Paf1 complex physically and functionally associates with transcription elongation factors in vivo. EMBO J. 21(7): 1764-1774.Lindstrom, D.L., and Hartzog, G.A. 2001. Genetic interactions of Spt4-Spt5 and TFIIS with the RNA Polymerase II CTD and CTD modifying enzymes in Saccharomyces cerevisiae. Genetics, 159: 487-497.Murray S, Udupa R, Yao S, Hartzog G, Prelich G. 2001. Phosphorylation of the RNA Polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase. Molecular and Cellular Biology, 21(13):4089-96.Wada, T., Takagai, T., Yamaguchi, Y., Ferdous, A., Imai, T., Hirose, S., Sugimoto, S., Yano, K., Hartzog, G.A., Winston, F., Buratowski, S., and Handa, H. 1998. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes and Development 12: 343-356.Hartzog, G.A., Wada, T., Handa, H., and Winston, F. 1998. Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Genes and Development 12: 357-369.Hartzog, G.A., Basrai, M.A., Ricupero-Hovasse, S.L., Heiter, P., Winston, F. 1996. Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae. Molecular and Cellular Biology 16: 2848-2856.Hartzog, G.A., and Myers, R.M. 1993. Discrimination among potential activators of the -Globin CACCC element by correlation of binding and transcriptional properties. Molecular and Cellular Biology 13: 44-56.De Souza, Y.G., Greenspan, D., Felton, J.R., Hartzog, G.A., Hammer, M., and Greenspan, J. 1989. Localization of the Epstein Barr virus in the epithelial cells of oral hairy leukoplakia by in situ hybridization in tissue. New England Journal of Medicine 320: 1559 (letter)Reviews (published prior to the period under review)Hartzog GA and Kaplan CD. Competing for the clamp: promoting RNA polymerase processivity and managing the transition from intiation to elongation. Mol. Cell, 2011, 43(2):161-163. (invited review)Hartzog GA, Martens JA. ncRNA transcription makes its mark. EMBO J. 2009 Jun 17;28(12):1679-80.Hartzog GA, Quan TK. Just the FACTs:histone H2B ubiquitylation and nucleosome dynamics. Mol Cell. 2008 Jul 11;31(1):2-4.Hartzog GA, Tamkun JW. 2007. A new role for histone tail modifications in transcription elongation. Genes Dev. 2007 Dec 15;21(24):3209-13.Electronic lecture for Henry Stuart Talks, “Coupling Transcription, RNA Processing and RNA Export.” 2006Hartzog, G. A. Recent advances in transcription elongation. 2003 Current Opinions in Genetics and Development. 13(2): 119-126.Hartzog, G.A., Speer, J., Lindstom, D.L. 2002 Transcript elongation on a nucleoprotein template. Biochemica Biophysica Acta, 1577: 276-286. Hartzog, G.A., and Winston, F. 1997. Nucleosomes and transcription: recent lessons from genetics. Current Opinions in Genetics and Development 7: 192-198.Myers, R.M., Cowie, A., Stuvé, L., Hartzog, G., and Gaensler, K. 1989. Genetic and biochemical analysis of the mouse beta-major globin promoter. Progress in Clinical and Biological Research 316: 117-127.Book Chapters (published prior to the period under review)Hartzog, G.A. 1998. PCR mediated one-step gene disruption. In: Current Protocols in Molecular BiologyMehlhorn, R.J., Maguire, J.J., Hartzog, G.A., and Packer, L. 1987. Oxygen radicals and cancer: free radical generation and oxidative damage in mitochondria. In: Oxygen and Cancer: Free Radical Generation and Oxidative Damage in Mitochondria and Biomembranes in Cancer Cells. Editors: T. Galeotti, A. Cittadini, G. Neri, and S. Papa. Elsevior Science Publications, Amsterdam.Hartzog, G.A., Mehlhorn, R.J., and Packer, L. 1987. A re-evaluation of the surface potential of the inner mitochondrial membrane using ESR techniques. In: Ion Interactions in Energy Transport Systems. Editors: S. Papa, G. Papageorgio, J. Baker. Plenum Publishing Company, New York.UNIVERSITY SERVICEDepartment of Molecular, Cellular & Developmental Biology2017Chair, Curriculum Committee2016Chair, Curriculum CommitteeDiversity CommitteeSearch committees for 2 staff advisor positions2015on sabbatical (F)Personnel Committee (W,Sp)2014Personnel CommitteeGraduate Admissions CommitteeHealth Sciences Advisory Committee2013Personnel CommitteeSpecial Committee to Revise the Biochemistry Curriculum2012Personnel Committee2011Health Sciences Advisory CommitteeAd hoc member of Curriculum CommitteePresentation on Human Biology Major to Assemblyman Bill Monning2010Health Sciences Advisory CommitteeAd hoc member of Curriculum CommitteePresentation on Human Biology Major to Life-Long Learners2009Health Sciences Advisory CommitteeGraduate Advising CommitteePresentation to Biology Students during new student orientation2008Graduate Advising CommitteePresentation to Biology Students during new student orientation2007Health Sciences Advisory Committee2006Vice-chair, MCD BiologyCurriculum committeeHealth Sciences Advisory Committee2005on sabbatical2004Graduate Advising CommitteeHealth Sciences Advisory CommitteeDepartmental Disaster Preparedness RepresentativeFaculty Search Committee (Chair)2003Graduate Advising CommitteeHealth Sciences Advisory CommitteeDepartmental Disaster Preparedness Representative2002Presentation to potential Graduate Students at the University of PittsburghGraduate Advising CommitteeStructural Biology Faculty Search Committee2001Participated in site visit for IMSD (formerly MBRS) GrantDepartmental representative at Scholar’s DayCurriculum Committee2000Represented MCD Biology at undergraduate student orientationDepartmental representative at Scholar’s DayCurriculum CommitteeDepartment of Biology1999-2000Curriculum CommitteeDivision of Physical and Biological Sciences2018Associate Dean for Academic Planning2016-presentPresentation to entering biology students on majors and research opportunities with faculty2006-presentFaculty co-Director, Cal-Teach2015Undergraduate Affairs review committee2013Career talks to students in EOP, ACE programs. Presentation to transfer students in the sciences on strategies for productively accessing and reading academic literature.2012-19Taught ACCESS program Mini-Research Camp (a short lab class for community college student candidates for the ACCESS program) two weeks per year2011Helped prepare a successful proposal to the Astellas Foundation for a $25,000 scholarship to an undergraduate student in the sciences.2010Biomed Building Space Committee2010-2012Director, Biochemistry and Molecular Biology Major2009-10Member, Dean’s/Chancellor’s Award Selection Committee2006-7Member of Task Force on the Health Sciences Major and Language Program2004 Biomed Planning CommitteeParticipated in Site visit for MARC grant2003-2007Biomed Building Committee2001Faculty Search Committee for Department of Environmental ToxicologyUniversity2019Member of Search Committee for EOP STEM AdvisorsReviewer for GloCal fellowships2016-presentPresentations on biology majors and research opportunities at orientations for new freshmen and transfer students at Oakes College. Weekly advising for students at Oakes college2012-presentMember, Independent Substantive Review Committee for Conflict of Interest 2013Search Committee for University Registrar2012Member, Undergraduate Student Success Team2012-13Presentations (4 total) to Dean’s Advisory Council, PBSci and Arts Divisions Chairs meetings, and CEP on major mapping project.2011Search committee member for STEM career advisor2010Member of Health Careers Advising Committee2009Search committee member for STEM career advisor2006Academic Senate, Committee on ResearchPROFESSIONAL ACTIVITIESConsultative or Other Service to Civic, State, or National Government Agencies2016Ad hoc member, NIH F05 study section2010-16Wellcome Trust grant reviews2010Natural Sciences and Engineering Research Council of Canada2007Ad hoc member, NIH special emphasis grant review panel2006-2010Member, NIH Molecular Genetics A (MGA) study section2006-2017Ad hoc reviewer of grants for the NSF2005Ad hoc reviewer, The Biotechnology and Biological Sciences Research Council (U.K.).The Association for International Cancer Research (U.K.).The Israel Science FoundationAd hoc member, NCI Leukemogenesis P01 cluster reviewAd hoc member, Molecular Genetics A (MGA) study section2003Ad hoc member, NIH ZRG1 CDF4 special study section2002-04Ad hoc member, NIH ZRG1 F05 study section2002-04Ad hoc reviewer of grants for the NSF2001Ad hoc reviewer of grant for Fundacao para a Ciencia e a Technologia, Portugal1999Ad hoc reviewer of grant for the Joint Infrastructure Trust, U.K.Service to Staff or Editorial Board of Scholarly Journals or Publications2011-presentReviewer for ACS Chemical Biology, Cell, Cell Reports, EMBO Journal, EMBO Reports, Epigentics and Chromatin, Genetics, Journal of Basic Microbiology, Molecular and Cellular Biology, Molecular Cell, NAR, PLOS Genetics, PNASParticipation in Public Lectures or Forums2016Research Deconstruction: Building Knowledge and Self-Efficacy by Demystifying Sophisticated Science. UCSC Active Learning Seminar.2010UCSC MCD Biology Departmental seminar with Manny Ares.“Phage Genomics Project Lab: A Phreshman Phusion of Teaching and Research”2007West Coast Chromatin Meeting2006Panel member for Alliance for Graduate Education and the Professoriate (NSF-AGEP) workshop on fellowship writing.Guest Panelist in ETOX 205, Scientific Grant Writing2005Speaker at West Coast Chromatin MeetingCenter for Adaptive Optics Professional Development Workshop2004“Connecting transcription elongation, chromatin and RNA processing.” FASEB meeting on transcriptional regulation during cell growth, differentiation, and development. Saxton’s River, Vermont“Connecting transcription elongation, chromatin and RNA processing.” ASBMB meeting on transcriptional regulation by chromatin and RNA polymerase II. Lake Tahoe, California.2002“Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins.”11th Biennial Meeting On Post-Initiation Activities of RNAPolymerases. 2001“Genetic Interaction of the Spt4-Spt5 complex and TFIIS with the Pol II CTD and CTD modifying enzymes.” FASEB summer conference on chromatin and transcription. 2001“Spt4/Spt5 complex function depends on the Pol II CTD and CTD modifying enzymes.” Cold Spring Harbor meeting on the mechanisms of eukaryotic transcription. (Poster)1999“Genetic Analysis of SPT5 Function in Saccharomyces Cerevisiae.” ASBMB meeting on Mechanisms and Regulation of Transcription by RNA Polymerase II.1999“Genetic Analysis of SPT5 Function in Saccharomyces Cerevisiae” Meeting on mechanisms of eukaryotic transcription, Cold Spring Harbor. (Poster)1997“Genetic and biochemical evidence that an Spt4-Spt5 complex regulates transcription elongation in Saccharomyces cerevisiae”, Hartzog, G.A. and Winston, F. Meeting on mechanisms of eukaryotic transcription, Cold Spring Harbor 1995“Genetic Analysis of SPT4 and SPT5 in S. Cerevisiae”, Winston, G.A., and Winston, F. FASEB meeting on chromatin and transcription, Snowmass. (Poster)1994“Identification of a functional human homolog of SPT4”, Hartzog, G.A., Ricupero-Hovasse, S., Winston, F. Yeast genetics and molecular biology meeting, Seattle.Invited Research Seminars2011“Contending with Chromatin: Overcoming the Nucleosomal Barrier to Transcription” Elongation, CSUMB.2008“Genetic Analysis of Transcription Elongation in Yeast”, Medical College of Wisconsin2007“Genetic Analysis of Transcription Elongation in Yeast”, San Jose State University2005“Connecting transcription elongation, chromatin and RNA processing.” University of Virginia2004“Connecting transcription elongation, chromatin and RNA processing.” St. Louis University.2003“Bringing it all together: transcription elongation, pre-mRNA processing and chromatin remodeling” University of Utah.2002"Using genetics and biochemistry to find new protein partners for the Spt4-Spt5 transcription elongation factor" National Cancer Institute.2002“Genetic and Biochemical Analysis of Transcription Elongation” University of Pittsburgh.2000"Genetic and Biochemical Analyses of the Spt4/Spt5 Transcription Elongation Factor in Saccharomyces cerevisiae" Departmental Seminar, UC Davis.1999“Genetic Analysis of the Transcriptional Elongation Factors Spt4 and Spt5 in Saccharomyces Cerevisiae” Departmental Seminar, Tokyo University.1999“Genetic Analysis of the Transcriptional Elongation Factors Spt4 and Spt5 in Saccharomyces Cerevisiae” International Symposuim on Transcriptional Regulatrion in Eukaryotes, Frontier Collaborative Research Center, Tokyo Institute of Technology.TEACHING I have taught the following courses while at UCSC:BIOL 204*, ChromatinBIOL 200B, Advanced Molecular BiologyBIOL 189/W, Health Sciences InternshipBIOL 188*, A Life in MedicineBIOL 186L, MCD Biology Undergraduate ResearchBIOL 121L*, Environmental Phage Biology Lab (a redesign of BIOL 21L)BIOL 115, Eukaryotic Molecular BiologyBIOL 109L, Yeast Molecular Genetics LabBIOL 101*, Molecular BiologyBIOL 88*, Studies in MedicineBIOL 86*, Research DeconstructionBIOL 21L*, Genomics Lab* Course founderI currently supervise 2 graduate students in my lab, serve on several thesis advisory committees host 5-10 undergraduate researchers per year, host high school students in the summer and teach short courses for the ACCESS and STEM Diversity programs, which aim to increase opportunities for underrepresented students in the sciences.A full description of my teaching activities is available upon request. ................
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