Position Posting: Clinical Scientist, Contract

Position Posting: Clinical Scientist, Contract (with potential for full-time)

Ripple Therapeutics Corporation is a clinical stage, privately held company that is focused on ophthalmic therapeutics with controllable, sustainable drug delivery. The core feature of Ripple's EpidelTM technology is the ability to engineer sustained-release pharmaceuticals with zero-order release kinetics without the use of polymers or excipients. Ripple has a full product pipeline in development.

Position Summary The Clinical Scientist is responsible for supporting the scientific analysis of the RIPPLE-1 Phase II Clinical Trial in ophthalmology. Responsibilities include managing aspects of the protocol that relate to the conduct of ophthalmological and imaging assessments, in combination with analysis, interpretation and presentation of the data. The Clinical Scientist is required to have experience in supporting early stage clinical trials, strong communication, analytical and organizational skills. Proficiency in Excel, PowerPoint, Word and experience with Medidata or other EDC platforms is required. This role requires frequent interaction with the internal Ripple Team (i.e. R&D, Quality, Management) along with Ripple's Clinical CRO (and associated vendors), external scientific and medical advisors.

Key Responsibilities Protocol Support o Field technical protocol-related queries from CRO and sites, liaising with team and external advisors as needed o Plan changes to EDC, incorporate user feedback, communicate to CRO, test updates

Data Management and Analysis o Review EDC and other data sources, raise queries on data as required o Maintain Excel dashboard and PowerPoint data summaries o Prepare graphs and presentations of data for internal and external use o Communicate results to internal team and external advisors o Prepare worksheets for clinical site use

Imaging (Reading Centre Liaison) o Field technical questions regarding imaging as they relate to the protocol o Liaise with Reading Centre Project Manager as needed on imaging and grading questions o Review updates to grading requirements

Recruitment and Retention o Provide scientific input on recruitment materials

MaRS Centre, South Tower, 101 College Street, Suite 300, Toronto, ON M5G 1L7

o Prepare training materials, including videos and presentations for sites on protocol/clinical data topics

o Present protocol and clinical data material during meetings with sites as needed and field questions on these topics

Ethics/Regulatory o Review draft regulatory and ethics submissions prepared by CRO o Contribute to responses to ethics and regulatory questions o Manage annual IB updates

Competitive Surveillance o Review news updates on competitive technologies and summarize for internal team

Education and Experience The ideal candidate will possess the following: 1. A minimum of a Masters, preferably a PhD, in a scientific field 2. A minimum of three years of experience in an early stage clinical research environment, preferably

includes ophthalmology experience 3. Ability to set priorities and creatively problem solve while working independently 4. English fluency including good written and verbal communication skills 5. Strong attention to detail and analytical skills

To Apply: ? Please submit resumes in confidence to careers@ with "Clinical Scientist" in the subject line. ? Ripple Therapeutics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. ? Compensation, including benefits and equity, is competitive and commensurate with experience. ? This is a great opportunity to work with engaged, committed and dedicated colleagues in an innovative and progressive environment. ? We thank you for your interest. Only those candidates selected for interviews will be contacted.

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MaRS Centre, South Tower, 101 College Street, Suite 300, Toronto, ON M5G 1L7

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