COMPARATIVE EFFECTIVENESS OF MANAGEMENT …



SUPPLEMENTARY DATA

Manuscript title: Comparative clinical effectiveness of management strategies for sciatica: systematic review and mixed treatment comparisons meta-analyses.

INCLUDES:

Web appendix A (pg 3): Winbug codes.

Web appendix B (pg 6): Description of the interventions, population, study design and outcome data for the pairwise studies.

Table B1 (pg 6): Description of interventions.

Table B2 (pg 11): Description of participants.

Table B3 (pg 21): Summary of overall quality of included studies.

Table B4 (pg 25): Outcome data for global effect.

Table B5 (pg 33): Outcome data for pain intensity.

Web appendix C (pg 37): Results of inactive control comparisons from network meta-analyses.

Table C1 (pg 37): Probability of being best and the ORs of global effect for different treatment strategies compared with inactive control from the network meta-analysis and pairwise meta-analyses.

Table C2 (pg 38): Probability of being best and the ORs for global effect of different treatment strategies compared with inactive control from the network meta-analysis and pairwise meta-analyses based on RCTs and Q-RCTs only.

Figure C1 (pg 39): Plot of the ORs of global effects for the different treatment strategies compared with inactive control from the network meta-analysis, based on RCTs and Q-RCTs only.

Table C3 (pg 40): Probability of being best and the weighted mean difference for pain intensity for different treatment strategies compared with inactive control from the network meta-analysis and pairwise meta-analyses.

Table C4 (pg 41): Probability of being best and weighted mean difference for pain intensity of different treatment strategies compared with inactive control from the network meta-analysis and pairwise meta-analyses based on RCTs and Q-RCTs only.

Figure C2 (pg 42): Plot of the weighted mean difference for pain intensity for the different treatment strategies compared with inactive control from the MTC analysis, based on RCTs and Q-RCTs only.

Web appendix D (pg 43): Results of network meta-analyses restricted to RCTs and Q-RCTs.

Table D1 (pg 43): Results (odds ratios ORs, with 95% confidence intervals/credible intervals) of network meta-analysis for RCTs/Q-RCTs reporting global effect.

Table D2 (pg 45): Results (weighted mean difference WMD, with 95% confidence intervals/credible intervals) of network meta-analysis for RCTs/Q-RCTs reporting pain intensity.

Results of sensitivity analyses (pg 46) (a narrative summary)

Appendix E (pg 47): Assessment of model fit and between study heterogeneity

WEB APPENDIX A: WINBUG CODES

These are based on those published on the Bristol University network meta-analysis webpage ()

GLOBAL

#Random-effects model for multi-arm trials

model{

for(i in 1:NS){

w[i,1] ................
................

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