DEFINITION OF SIGNIFICANT CHANGES TO ANIMAL USE …
DEFINITION OF SIGNIFICANT CHANGES TO ANIMAL USE PROTOCOLS
Significant changes to animal use protocols REQUIRE approval by the Institutional Animal Care & Use Committee (IACUC) prior to the activities being performed. You may report changes to the Chair of the IACUC in a memo. To ensure that you provide the necessary detail, appropriate sections from the IACUC Assurance of Animal Care Form may be copied and pasted into your memo. The following is a list of changes which are considered significant by the IACUC. If there are questions regarding whether specific changes are significant, assistance can be obtained by contacting Dr. Eric S. Murphy, afesm@uaa.alaska.edu.
Significant changes include, but are not limited to, changes in/of:
• Genus or species of animal used: [provide a rationale for use of the new genus/species]
• Addition of animals to project which are being used or have been used on other projects: [note from which project and investigator the animals are being transferred]
• Increase in the number of previously approved animals to be used: [provide justification for the increase]
- A 10% increase or more in the number of rodents, fish, reptiles or amphibians to be used
- ANY increase in the number of rabbits, dogs, cats, or other larger species
• Addition of any procedure that may increase pain, distress, or discomfort: [provide a detailed description of the procedure(s)]
• Surgical procedure from terminal to survival; single to multiple; minor to major; change in facility where surgery is performed: [describe and justify changes]
• Adding or discontinuing anesthesia and/or analgesia; or changing agent, dose, or route: [describe and justify changes]
• Euthanasia method or use of death as an endpoint: [describe and justify changes]
• Antibody production and/or harvesting procedures: [describe changes in adjuvant used, volume, route, frequency of administration, harvest protocol - provide explanation/justification]
• Addition of any Research/Teaching personnel performing animal procedures: [Fill out new personnel form available on web]
• Changes in drug/reagent/chemical/cell type being administered: [describe and justify changes in agent, dose, volume, frequency of administration and alternation in anticipated side effect]
• Addition/changes in areas to which animals to be taken and held from animal housing area for more than 12 hours; e.g., labs, procedure rooms, surgeries: [describe location, length of time in study area - provide justification]
• Deprivation of food and/or water over 12 hours; change in diet producing a nutritional deficit: [describe and justify length of deprivation, change in diet]
• Behavioral testing and/or noxious stimulus applied: [describe and justify testing procedures, noxious stimuli]
• Blood sampling protocol: [describe and justify changes in withdrawal site, increase in frequency, increase in volume, especially when volume being drawn being greater than 10% of the animal’s blood volume]
• Restraint method: [describe changes in method, frequency, equipment used - provide justification]
• Use of paralytic agent: [describe agent, dose, frequency, monitoring protocol - provide justification]
• Involvement of another institution or agency in the project. [Fill out new personnel form available on web]
• Any alteration in live trapping or immobilization protocol: [describe and justify changes]
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