Webinar - The End of Statistical Significance Testing
March 28, 2019
The End of Statistical Significance Testing
Meet Our Team
Kenneth J. Rothman, DrPH Distinguished Fellow, Vice President of Epidemiology Research
Heather Danysh, PhD Research Epidemiologist
2
Physician's Health Study
Acute MI Stroke Ischemic Heart Disease Sudden Death Other Cardiovascular Other Cerebrovascular
Aspirin N= 11,037
5 6
9
13
10
1
Placebo N=11,034 RR 95% CI
18
0.25 0.11--0.56
2
3.00 0.75--12.0
8
1.08 0.42--2.8
9
1.49 0.65--3.4
6
1.79 0.67--4.76
1
1.00 0.06--16.0
"Furthermore, among the six categories of deaths from vascular causes, there was no significant excess in the aspirin group within any single category that would counterbalance the deficit in fatal myocardial infarction (5 in the aspirin group and 18 in the placebo group)."
NEJM 1988; 318:262-264
3
Physician's Health Study
Acute MI Stroke Ischemic Heart Disease Sudden Death Other Cardiovascular Other Cerebrovascular Total Cardiovascular
Aspirin N= 11,037
5 6
9 13 10 1 44
Placebo N=11,034 RR 95% CI
18
0.25 0.11--0.56
2
3.00 0.75--12.0
8
1.08 0.42--2.8
9
1.49 0.65--3.4
6
1.79 0.67--4.76
1
1.00 0.06--16.0
44
0.99 0.65--1.5
"Furthermore, among the six categories of deaths from vascular causes, there was no significant excess in the aspirin group within any single category that would counterbalance the deficit in fatal myocardial infarction (5 in the aspirin group and 18 in the placebo group)."
NEJM 1988; 318:262-264
4
Physician's Health Study
Acute MI Stroke Ischemic Heart Disease Sudden Death Other Cardiovascular Other Cerebrovascular Total Cardiovascular
Aspirin N= 11,037
5 6
9 13 10 1 44
Placebo N=11,034
18 2
8 9 6 1 44
RR 95% CI
0.25 0.11--0.56 3.00 0.75--12.0 1.08 0.42--2.8 1.49 0.65--3.4 1.79 0.67--4.76 1.00 0.06--16.0 0.99 0.65--1.5
P-value 0.006 0.16 0.81 0.40 0.31 1.00 0.99
"Furthermore, among the six categories of deaths from vascular causes, there was no significant excess in the aspirin group within any single category that would counterbalance the deficit in fatal myocardial infarction (5 in the aspirin group and 18 in the placebo group)."
NEJM 1988; 318:262-264
5
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