Local.brookings.k12.sd.us
NAME _____________________________ f12
Chapter 14 –HONORS GENETIC DISORDERS TEST
(2 points each)
MATCHING:
Match the genetic disorder with its description.
________ Change in hemoglobin gene causes red blood cells to
change shape causing circulatory problems A. ACHONDROPLASIA
B. HUNTINGTON’s
________ Degenerative brain disorder caused by extra CAG repeats C. COLORBLINDNESS
in the gene code whose symptoms appear around middle age D. TAY-SACHS
and result in nursing home care and eventually death E. HEMOPHILIA
F. SICKLE CELL DISEASE
________ Inability to distinguish between certain colors G. CYSTIC FIBROSIS
(especially red and green) H. PHENYLKETONURIA
I. TURNER SYMDROME
_______ Mutation in a blood clotting protein so individuals can’t stop J. DOWN SYNDROME
bleeding if injured K.KLINEFELTER SYNDROME
L. DUCHENNE MUSCULAR
_______ Mutation in gene that breaks down the amino acid phenylalanine DYSTROPHY
which accumulates in their brain and persons become retarded if
they eat foods containing phenylalanine.
_______ Mutation in muscle proteins that gradually weakens and
destroys muscle tissue
_______ Syndrome in which a person has an extra #21 chromosome
causing mental retardation and often heart defects
_______ Females with only one X chromosome (XO)
_______ Males with extra X chromosomes (XXy, XXXy, XXXXy)
_______ Defect in ion channels which transport Cl- ions causing mucous to build up
in lungs and digestive organs
_______ Enzyme defect that causes lipids to build up in the brain;
Results in blindness, retardation, and death by age 5
_______ Defect in bone formation resulting in a person with a normal size
head and torso, but short arms and legs
MATCHING:
Match the genetic disorder with its description.
________ Change in hemoglobin gene causes red blood cells to
change shape causing circulatory problems A. TAY-SACHS
B. ACHONDROPLASIA
________ Degenerative brain disorder caused by extra CAG repeats C. HUNTINGTON’s
in the gene code whose symptoms appear around middle age D. COLORBLINDNESS
and result in nursing home care and eventually death E. HEMOPHILIA
F. CYSTIC FIBROSIS
________ Inability to distinguish between certain colors G. DOWN SYNDROME
(especially red and green) H.KLINEFELTER SYMDROME
I. TURNER SYNDROME
_______ Mutation in a blood clotting protein so individuals can’t stop J. SICKLE CELL DISEASE
bleeding if injured K. PHENYLKETONURIA
L. DUCHENNE MUSCULAR
_______ Mutation in gene that breaks down the amino acid phenylalanine DYSTROPHY
which accumulates in their brain and persons become retarded if
they eat foods containing phenylalanine.
_______ Mutation in muscle proteins that gradually weakens and
destroys muscle tissue
_______ Enzyme defect that causes lipids to build up in the brain;
Results in blindness, retardation, and death by age 5
_______ Defect in bone formation resulting in a person with normal size
head and torso, but short arms and legs
_______ Syndrome in which a person has an extra #21 chromosome
causing mental retardation and often heart defects
_______ Females with only one X chromosome (XO)
_______ Males with extra X chromosomes (XXy, XXXy, XXXXy)
_______ Defect in ion channels which transport Cl- ions causing mucous to build up
in lungs and digestive organs
MATCHING:
Match the genetic disorder with its description.
________ Change in hemoglobin gene causes red blood cells to
change shape causing circulatory problems A. PHENYLKETONURIA
B. CYSTIC FIBROSIS
________ Degenerative brain disorder caused by extra CAG repeats C. HUNTINGTON’s
in the gene code whose symptoms appear around middle age D. COLORBLINDNESS
which results in nursing home care and eventually death E. HEMOPHILIA
F. SICKLE CELL DISEASE
________ Inability to distinguish between certain colors
(especially red and green)
_______ Mutation in a blood clotting protein so individuals can’t stop
bleeding if injured
_______ Mutation in gene that breaks down the amino acid phenylalanine
which accumulates in their brain and persons become retarded if
they eat foods containing phenylalanine.
_______ Defect in ion channels which transport Cl- ions causing mucous to build up
in lungs and digestive organs
* * * * * * * * * * * * * * *
_______ Mutation in muscle proteins that gradually weakens and
destroys muscle tissue A. TURNER SYNDROME
B. DOWN SYNDROME
_______ Enzyme defect that causes lipids to build up in the brain; C. TAY-SACHS
Results in blindness, retardation, and death by age 5 D.KLINEFELTER SYNDROME
E. ACHONDROPLASIA
_______ Defect in bone formation resulting in a person with a F. DUCHENNE MUSCULAR
normal size head and torso, but short arms and legs DYSTROPHY
_______ Syndrome in which a person has an extra #21 chromosome
causing mental retardation and often heart defects
_______ Females with only one X chromosome (XO)
_______ Males with extra X chromosomes (XXy, XXXy, XXXXy)
MULTIPLE CHOICE:
Tell how each of the following disorders is inherited:
_______ Achondroplasia ________ Sickle Cell Disease
A. autosomal dominant A. autosomal dominant
B. autosomal recessive B. autosomal recessive
C. autosomal COdominant C. autosomal COdominant
D. X-linked recessive D. X-linked recessive
E. nondisjunction E. nondisjunction
_______ Hemophilia ________ Tay-Sachs disease
A. autosomal dominant A. autosomal dominant
B. autosomal recessive B. autosomal recessive
C. autosomal COdominant C. autosomal COdominant
D. X-linked recessive D. X-linked recessive
E. nondisjunction E. nondisjunction
_______ Down syndrome ________ Colorblindness
A. autosomal dominant A. autosomal dominant
B. autosomal recessive B. autosomal recessive
C. autosomal COdominant C. autosomal COdominant
D. X-linked recessive D. X-linked recessive
E. nondisjunction E. nondisjunction
_______ Duchenne Muscular Dystrophy ________ Phenylketonuria (PKU)
A. autosomal dominant A. autosomal dominant
B. autosomal recessive B. autosomal recessive
C. autosomal COdominant C. autosomal COdominant
D. X-linked recessive D. X-linked recessive
E. nondisjunction E. nondisjunction
_______ Cystic Fibrosis ________ Turner syndrome
A. autosomal dominant A. autosomal dominant
B. autosomal recessive B. autosomal recessive
C. autosomal COdominant C. autosomal COdominant
D. X-linked recessive D. X-linked recessive
E. nondisjunction E. nondisjunction
_______ Klinefelter syndrome ________ Huntington’s disease
A. autosomal dominant A. autosomal dominant
B. autosomal recessive B. autosomal recessive
C. autosomal COdominant C. autosomal COdominant
D. X-linked recessive D. X-linked recessive
E. nondisjunction E. nondisjunction
NAME _____________________________ (f12)
Chapter 14 –HONORS GENETIC DISORDERS TEST
(2 points each)
MULTIPLE CHOICE:
Put the letter of the answer that best completes the statement on the blank at the left.
_______ In humans an XX genotype makes you a ___________________
A. male
B. female
C. mutant
D. carrier
________ __________________ cell mutations happen in sperm or eggs and can be passed on to the offspring.
A. body
B. somatic
C. germ
D. allele
________ ____________________ mutations cause death, often before birth.
A. Somatic cell
B. X-linked
C. Germ cell
D. Lethal
________ __________________ cell mutations happen in body cells so they affect the organism itself,
but are NOT passed on to offspring.
A. Gamete
B. Somatic
C. Germ
D. Allele
_______ In humans an Xy genotype makes you a ____________________.
A. male
B. female
C. mutant
D. carrier
________ A gene that is carried on an X or Y chromosome is called ______________________.
A. sex influenced
B. sex linked
C. autosomal
D. lethal
________ The failure of homologous chromosomes to separate during meiosis is called ______________
A. nondisjunction
B. frameshift
C. crossing over
D. synapsis
________ A family record that shows how a trait is inherited
over several generations is called a _____________
A. karyotype
B. Punnett square
C. pedigree
D. periodic table
________ A person that has one copy of a recessive autosomal allele and does not express the trait but can pass it on to his/her offspring is called a __________________.
A. mutant
B. carrier
C. hemophiliac
D. gene marker
________ _______________________ can be carriers for AUTOSOMAL RECESSIVE disorders.
A. Only males
B. Only females
C. Both males and females
________ _______________________ can be carriers for X-LINKED RECESSIVE disorders.
A. Only females
B. Only males
C. Both males and females
________ A human cell with 3 copies of a chromosome would have 47 chromosomes instead of 46. This condition is called ____________________.
A. monosomy
B. disomy
C. tetrads
D. trisomy
________ _____________________________ twins have identical DNA.
A. monozygotic
B. dizygotic
C. fraternal
D. trisomic
________ This picture of an organism’s chromosomes is called a ______________________
A. pedigree
B. Punnett square
C. karyotype
________ The chromosomes that DO NOT determine sex are called ____________________
A. sex chromosomes
B. autosomes
C. gene markers
D. pedigree partners
________ Which parent determines the sex of the baby?
A. father
B. mother
________ The dense region in the nucleus of female cells that forms when one of the X chromosomes is randomly inactivated is called a _____________________ body.
A. autosomal
B. sex-linked
C. nucleolus
D. Barr
______ Persons who are heterozygous for _____________________ are resistant to malaria.
A. hemophilia
B. Down syndrome
C. sickle cell
D. cystic fibrosis
________ Turner’s syndrome is an example of a _____________________ disorder.
A. trisomy
B. monosomy
C. somatic cell mutation
________ X-linked recessive disorders show up more frequently in ____________________.
A. females
B. males
________ Sickle cell disease is found more frequently in __________________________ populations.
A. Jewish
B. Caucasians
C. African American
________ Tay-Sachs disease is found more frequently in_________________________ populations.
A. male
B. Caucasion
C. African American
D. Jewish or Middle Eastern
________ Cystic fibrosis is found more frequently in _______________________ populations.
A. male
B. Caucasion
C. African American
D. Jewish or Middle Eastern
_________ Which food group must people with phenylketonuria avoid?
A. carbohydrates
B. proteins
C. lipids
_________ This shows a person with
A. Klinefelter syndrome
B. Down syndrome
C. Turner syndrome
_________ People who are heterozygous for the ________________ allele are resistant to malaria.
A. hemophilia
B. cystic fibrosis
C. sickle cell disease
D. Huntington’s disease
* * * * * * * * * * * * * * *
Match the symbol letter with the correct description
Which member of this family shows the trait?
A B C D E F
Which represents a male is a carrier for this trait?
A B C D E F
A and E in the diagram above are __________________
A. normal females
B. normal males
C. diseased males
D. diseased females
B and D in the diagram above are __________________
A. normal males
B. carrier males
C. diseased females
D. carrier females
BONUS
Think about it: Several genetic disorders you learned about result from the inability to break down some molecule. Which cell part do you think has lost its function?
_________________________
Name the autosomal recessive disorder carried on chromosome #21 mentioned in your book, that is named after a famous athlete who had the disorder.
__________________________________________
Tell how the disorder shown at the left is inherited
(HINT- look at A) Circle one
Autosomal recessive Autosomal dominant X-linked recessive
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