Attachment: Extract from Clinical Evaluation Ranolazine

ACS. Acute coronary syndrome. ACTH. ... Therefore ranolazine acts to reduce these intracellular ionic imbalances during ischemia. Reduction in cellular Ca2+ overload is expected to reduce myocardial stiffness, oxygen consumption, and adenosine triphosphate (ATP) utilisation, and to improve blood flow to the microvasculature. ... and sinus node ... ................
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