IMMEDIATE VERSUS EARLY VERSUS
VOLUME 01
NUMBER 1
DECEMBER 2019
IMMEDIATE VERSUS EARLY VERSUS DELAYED POST-EXTRACTIVE IMPLANTS
4 X 4 MM VERSUS LONGER IMPLANTS IN POSTERIOR JAWS
3 MM VERSUS 4 MM DIAMETER IMPLANTS IN HORIZONTALLY AUGMENTED BONE
Clinical Trials in Dentistry
Editorial
CLINICAL TRIALS IN DENTISTRY, A NEW EVIDENCE-BASED JOURNAL FOR THE DENTAL PROFESSION
I am proud to present a new scientific clinical journal "Clinical Trials in Dentistry". The focus of this new journal is to provide reliable scientific evidence to clinicians and patients on the most effective interventions in dentistry. Why a new journal? This is the most common question I am asked. A new journal is needed because there are no other journals in dentistry specifically publishing reliable clinical trials in a broad range of dental specialties, keeping in mind that the relevance of clinical research will increase in the near future also for the industry due to new European regulations soon to be implemented. Relevant and transparent randomised controlled trials, cohort studies, case-control studies and systematic reviews focussing on patient treatments in dentistry are warmly welcomed. The journal will be published by the Italian publisher EDRA. EDRA is an emerging publishing house in the scientific world that strongly believes in this project, sharing our vision and ambitions and is courageously supporting us in this new adventure. Our aim is not to publish a mass of articles but filter relevant and honest papers that will help all of us in taking evidence-informed clinical decisions for better patient care. It will take some time to be listed in Scopus, Science Citation Index, Medline and to obtain an impact factor, but as we did it before, we shall do it again. I will be assisted by two valid and prepared Associate Editors: Michele Nieri and Jacopo Buti. Both have an extensive experience in international research, additional degrees in statistics and are from the town where Renaissance was born, Florence. We shall try our best to select impartially and promote the best manuscripts according to scientific standards. We are optimistic and strongly motivated so time will tell about this new adventure, hoping that the loyal, the brave and the bold readers will follow us.
Happy reading Marco, Michele and Jacopo
Clinical Trials in Dentistry 2019;01(1):1
Doi: 10.36130/CTD.01.2019.01
1
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NEWSLETTER Editor in Chief Prof. LORENZO BRESCHI
Biomedical and Neuromotor Science Department, University of Bologna ? president AIC, EFCD, IAAD and Past president IADR e ADM
Clinical Trials in Dentistry
CTD
CONTENTS
EDITORIAL Clinical Trials in Dentistry, a new evidence-based journal for the dental profession
Marco Esposito, Michele Nieri, Jacopo Buti
1
RANDOMISED CONTROLLED TRIALS Immediate, early (6 weeks) and delayed (4 months) single post-extractive
implants: 3-year post-loading data from a randomised controlled trial
Pietro Felice, Carlo Barausse, Jacopo Buti, Manlio Gessaroli, Marco Esposito
5
Posterior jaw rehabilitation using partial prostheses supported by impants 4.0 x 4.0 mm
or longer: three-year post-loading results of a multicentre randomised controlled trial
Carlo Barausse, Pietro Felice, Roberto Pistilli, Jacopo Buti, Marco Esposito
25
Immediate, early (6 weeks) and delayed loading (3 months) of single, partial and full fixed
implat-supported prostheses: three-year post-loading data from a multicentre
randomisez controlled trial
Roberto Pistilli, Miltiadis Mitsias, Marco Esposito, Konstantinos Siormpas, Luca Sbricoli,
Jacopo Buti, Hassan Maghaireh
37
Immediate loading of 3 mm-diameter implants as an alternative to horizontal bone
augmentation for placing normal diameter implants: four-month post-loading results
from a multicentre randomised controlled trial
Carlo Barausse, Marco Esposito, Roberto Pistilli, Jacopo Buti, Pietro Felice
51
Crestal versus lateral sinus lift: one-year results from a within-patient
randomised controlled trial
Erta Xhanari, Marco Tallarico, Silvio Mario Meloni, Zamira Kalemaj,
Francesco Mattia Ceruso, Edlira Dedaj, Marco Esposito
67
Efficacy of four motivational techniques for improving oral hygiene.
One-year follow-up of a randomised controlled trial
Monica Giani, Umberto Pagliaro, Lorenzo Franchi, Roberto Rotundo, Michele Nieri
79
Clinical Trials in Dentistry 2019;01(1)
3
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?2019 EDRA SpA CLINICAL TRIALS IN DENTISTRY - Frequency: Quarterly Registered at Tribunale di Milano, n. 151 on 3.7.2019
Editor in Chief
Marco Esposito
Associate Editors
Jacopo Buti Michele Nieri
Editorial Board
Gil Alcoforado Giulio Alessandri Bonetti Carlo Barausse Antonio Barone Caroline Bolle Lorenzo Breschi Francesco Cairo Gioacchino Cannizzaro Paolo Cappar? Pietro Felice Federica Fonzar Lorenzo Franchi Massimo Gagliani
Roberta Gasparro Enrico Gherlone Amerigo Giudice Giovanna Iezzi Zamira Kalemaj Stavros Kiliaridis Thomas Kvist Giovanni Lodi David Madruga Hassan Maghaireh Zeina Majzoub Daniele Manfredini Gaetano Marenzi
Annalisa Mazzoni Silvio Mario Meloni Eitan Mijiritsky Umberto Pagliaro David Pe?arrocha Paolo Pera Roberto Pistilli Carlo Poggio Roberto Rotundo Gilberto Sammartino Luigi Stefanelli Marco Tallarico
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Pietro Felice, Carlo Barausse, Jacopo Buti, Manlio Gessaroli, Marco Esposito
KEY WORDS delayed implants, early implants, immediate post-extraction implants, single implants, socket preservation
Randomised controlled trial
IMMEDIATE, EARLY (6 WEEKS) AND DELAYED (4 MONTHS) SINGLE POSTEXTRACTIVE IMPLANTS: 3-YEAR POST-LOADING DATA FROM A RANDOMISED CONTROLLED TRIAL
PIETRO FELICE, MD, DDS, PHD
Associate Professor, Odontostomatologic Surgery, Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy
CARLO BARAUSSE, DDS, PHD
Research Fellow, Odontostomatologic Surgery, Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy
JACOPO BUTI, DDS, PHD, MPERIO RCSED
Associate Professor, Unit of Periodontology, UCL Eastman Dental Institute, London, UK
MANLIO GESSAROLI, MD, PHD
Resident, Unit of Maxillofacial Surgery, AUSL Romagna, Bufalini Hospital, Cesena, Italy
MARCO ESPOSITO, DDS, PHD
Freelance researcher and Associate Professor, Department of Biomaterials, The Sahlgrenska Academy at G?teborg University, G?teborg, Sweden
Correspondence to: Marco Esposito Casella Postale 34, 20862 Arcore (MB), Italy E-mail: espositomarco@
PURPOSE. To compare the clinical outcome of single implants placed immediately after tooth extraction with those placed 6 weeks after tooth extraction (early placement), and those placed 4 months after extraction and socket healing (delayed placement).
MATERIALS AND METHODS. Two hundred and ten patients requiring one single implant-supported crown to replace a tooth to be extracted were randomised into 3 groups of 70 patients each to receive immediate, early (at 6 weeks), or delayed (after 4 months of healing) post-extraction implants, according to a parallel-group design. When needed, patients from the immediate and early groups had bone substitute grafts in the extraction socket, covered with a resorbable membrane, at implant placement. Sockets randomised to delayed implants were grafted in the same manner if poorly preserved, or in the "aesthetic" areas (from second upper premolar to second upper premolar). Implants inserted with at least 25 Ncm torque were left to heal unloaded for 4 months, whereas those inserted with less than 25 Ncm were left to heal unloaded for 6 months. Temporary crowns were delivered, and were to be replaced by definitive ones after 4 months. Outcome measures were crown and implant failures; complications; peri-implant marginal bone level changes; aesthetics, as assessed using the pink aesthetic score (PES); and patient satisfaction, recorded by blinded assessors. Patients were followed-up for 3 years post-loading.
RESULTS. Three years after loading, drop-outs were: five (7.1%) patients from the immediate, nine (12.9%) from the early, and eight (11.4%) from the delayed group. Five implants (9.2%) failed in the immediate, four (6.6%) in the early, and one (1.6%) in the delayed group (P [Freeman-Halton] = 0.282). Apart from the crowns that failed due to implant losses, no other definitive crown had to be remade. Complications affected eleven patients from the immediate group, 12 from the early, and eight from the delayed group (P [chi-square test] = 0.596). Mean peri-implant marginal bone loss after 3 years was -0.33 ? 0.22 mm at immediate, -0.43 ? 0.26 mm at early, and -0.49 ? 0.30 at delayed implants; (P [Kruskal Wallis test] ................
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