Pathophysiology of Type 2 Diabetes Mellitus

Pathophysiology of type 2 diabetes mellitus

R. Leibel Naomi Berrie Diabetes Center 25 February 2008

Body Mass Index Chart

25-29.9 = overweight; 30-39.9= obese; >40= extreme obesity

Weight (lbs)

120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 5'0" 5'2" 5'4" 5'6"

Height

5'8" 5'10"

6'0" 6'2" 6'4"

1

Prevalence of Obesity and Diagnosed Diabetes Among US Adults, 1991 and 2001

1986 -> 2000. BMI > 30 2x; >40 4x; > 50 6x.

Mokdad, A. H. et al. JAMA 2003;289:76-79

Relative Risk of Type 2 Diabetes in US Women According to BMI

Relative risk 100 (age-adjusted)

80

60

40

20

0 Bars represent 95% ................
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