CV - University of Colorado Denver
Brian L. Stauffer, MD, FACC, FACP
January 8, 2020
Research Addresses Hospital Address
Univ. of Colorado at Boulder Univ. of Colorado Denver Denver Health
Integrative Vascular Biology Laboratory Medicine/Cardiology 777 Bannock Street, MS 0960
Campus Box 354 12700 E. 19th Ave, Rm 8011 Dept. of Cardiology
Boulder, CO 80309-0354 RC2, B139 Denver, CO 80204
Ph: 303-735-3605 Aurora, CO 80045 Phone: 303-602-3858
Email: brian.stauffer@ucdenver.edu Ph: 303-724-5440
Education and Professional Experience:
Eastern Mennonite University, Harrisonburg, Virginia
Attendance: August 1987 through May 1991
Degree: Bachelor of Science in Biology, Minor in Computer Science,
Summa Cum Laude, GPA: 4.0, Class Rank: 1
The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA
Attendance: August 1991 through June 1993
June 1994 through May 1996
Degree: MD conferred May 19, 1996
Howard Hughes Medical Student Research Training Fellowship. Mentors: Dr. Russell L. Moore, Ph.D., Professor, Dept.
of Kinesiology, University of Colorado at Boulder, and Dr. Joseph Y. Cheung M.D., Ph.D., Professor of Medicine & Cellular and Molecular Physiology, Penn State University, College of Medicine. June 1993 through June 1994.
Resident, Internal Medicine Training Program, University Hospitals of Cleveland, Cleveland, OH
Employment: June 1996 through June 1999
Board Eligible in Internal Medicine July 1, 1999
Board Certified in Internal Medicine October 1999
Clinical Fellow, Cardiology Fellowship Training Program, University of Colorado Health Sciences Center, Denver, CO
Employment: July 1999 through June 2005
Postdoctoral Fellow, University of Colorado at Boulder, Department of Molecular, Cellular and Developmental Biology.
Mentor: Leslie A. Leinwand, Professor and Chair, Department of Molecular, Cellular and Developmental Biology.
October 1999 through June 2004
Instructor, University of Colorado Health Sciences Center, Department of Medicine, Denver, CO
Appointment: August 2000 through June 2005
Member, General Advisory Committee and Scientific Advisory Committee, Adult General Clinical Research Center, UCDHSC
Appointment: September 2005 through 2008
Medical Director, University of Colorado at Boulder, Integrative Vascular Biology Laboratory. Department of Integrative Physiology.
Appointment: August 2000 through Present
Graduate Faculty, University of Colorado at Boulder, Department of Integrative Physiology.
Appointment: January 2003 through Present
Assistant Professor, Denver Health and University of Colorado at Denver and the Health Sciences Center, Department of Medicine, Division of Cardiology, Denver, CO.
Appointment: July 2005 through June 2011
Assistant Professor Adjunct, University of Colorado at Boulder, Department of Integrative Physiology.
Appointment: April 2006 through May 2014
Member, Scientific Advisory Research Committee, Colorado Clinical Translational Sciences Institute, UCDSOM
Appointment: 2008 through Present
Co-founder and PI, Pediatric Cardiovascular Research Laboratory (PCRL). The mission of this multidisciplinary research group is to perform translational and molecular research focused on children with heart disease. Expertise within the laboratory spans the cardiovascular field from pediatric to adult disease and from basic molecular biology to cardiovascular physiology and clinical translation. The PCRL consists of 15-20 individuals directed by the multidisciplinary faculty (Dr. Miyamoto, Stauffer and Sucharov). July, 2009 through Present
Associate Professor, Denver Health and University of Colorado at Denver Anschutz Medical Campus,
Department of Medicine, Division of Cardiology, Denver, CO.
Appointment: July 2011 through 2019
Department of Integrated Physiology, University of Colorado at Denver Anschutz Medical Campus
Appointment: January 2014 through Present
Associate Professor Adjunct, University of Colorado at Boulder, Department of Integrative Physiology.
Appointment: June 2014 through Present
Medical Director, CU Boulder Clinical Translational Research Center, Colorado Clinical Translational Sciences Institute, UCDSOM
Appointment: April 2016-present
Interim Chief, Division of Cardiology, Denver Health Medical Center,
Appointment: June 1, 2017-September 30, 2017
Chief, Division of Cardiology, Denver Health Medical Center
Appointment: October 1, 2017-present
Professor, Denver Health and University of Colorado at Denver Anschutz Medical Campus,
Department of Medicine, Division of Cardiology, Denver, CO.
Department of Integrated Physiology, University of Colorado at Denver Anschutz Medical Campus
Appointment: July 2019 to Present
Honors:
Board Certified in Cardiology (2005)
Jacqueline Marie Leaffer CWHR Travel Award, UCHSC Center for Women’s Health Research (2006)
ASG/ASP/AHA T. Franklin William Scholar (2007-2009)
Fellow, American College of Cardiology (FACC) (2007)
Travel Award, Donald W. Reynolds FD~AGE Consensus Conference on Developing Core Curricula in Geriatrics for
Subspecialty Residents, Duke University School of Medicine (2007)
Finalist, Northwestern Cardiovascular Young Investigators’ Forum (2008)
Travel Award, American Physiologic Society – Sex Steroids and Gender in Cardiovascular-Renal Physiology and Pathophysiology (2009)
Finalist, Northwestern Cardiovascular Young Investigators’ Forum (2009)
CWHR Travel Award, UCD Center for Women’s Health Research (2012)
T. Franklin Williams/Dennis W. Jahnigen Leadership Retreat (2013)
Fellow, American College of Physicians (FACP) (2014)
2015 Academic Excellence Award, Denver Health Medical Staff, Denver Health and Hospital Authority (2015)
Recertified Boards in Cardiovascular Disease (2015)
Cardiology Fellowship
Board Certified in Internal Medicine (1999)
Outstanding Research Fellow Award, (2000) Univ. of Colorado Health Sciences Center, Dept. of Cardiology
Harvey Proctor fellowship award, (2001) American College of Cardiology
Outstanding Research Fellow Award, (2001) Univ. of Colorado Health Sciences Center, Dept. of Cardiology
Heart Failure Society of America Travel Grant, (2001)
GSK Research & Education Foundation for Cardiovascular Disease, Travel Award, (2002)
Heart Failure Society of America Travel Grant, (2002)
Finalist, AstraZeneca Cardiovascular Young Investigators Forum (2003)
Burroughs Wellcome Foundation/Howard Hughes Medical Institute Laboratory Management Course Travel Grant (2004)
Medical School
The Howard E. Morgan Award, (1996): For outstanding achievement in basic research
The Merck Manual Award, (1996): For excellence in academic performance
Basic Science Award, (1996): For the Annual Student Research Symposium
Howard Hughes Medical Student Research Training Fellowship (1993-1994)
Undergraduate:
Menno Simons Scholarship, (1987-1991) Academic Excellence Award
Lehman Scholarship, (1989-1990) Biological Science Achievement Award
Collins Scholarship, (1990-1991) Biological Science Achievement Award
Dean's List, (1987-1991)
Professional Organizations
American Physiological Society (1994-present)
American College of Physicians/American Society of Internal Medicine (1997-present); Fellow (2014-present)
American College of Cardiology (1999-present); Fellow (2007-present)
American Heart Association (2001-present)
Service
Education Committee, UCD HSC Cardiovascular Training Program 2006-present
Co-Director: Cardiovascular Training Program Core Curriculum, UCD Div. of Cardiology, 2006-2007
Director: Cardiovascular Training Program Core Curriculum, UCD Div. of Cardiology, 2007-2017
Member, General Advisory Committee and Scientific Advisory Committee, Adult General Clinical Research Center, UCDHSC Appointment: September 2005 through 2008
Member, Scientific Advisory Research Committee, Colorado Clinical Translational Sciences Institute, UCDHSC
Appointment: 2008 through present
Small Group Preceptor: UCD Medical Student Curriculum: Cardiovascular Sub-block. 2010-Present
Invited Abstract Reviewer: American Federation for Medical Research, Western Regional Meeting, 2006-2010
Invited Member: AHA Study Section, March 2010
Ad Hoc Member: CICS NIH Study Section, 2011
Safety Officer: POEM Study, Pioglitazone and Exercise Effects on Older Adults with Mild Cognitive Impairment and Metabolic Syndrome, PI: Robert Schwartz, MD. 2011-2013
Member, National CardioSurve Research Panel, American College of Cardiology, 2011-2013
Member, University of Colorado Center For Women’s Health Research: Grant Review Committee, 2012-Present
International Reviewer, GACR, Czech Science Foundation grant program (2012 and 2013 programs)
Faculty, “Florence International Symposium on Advances in Cardiomyopathies”, European Society of Cardiology, Myocardial and Pericardial Disease working group symposium, Florence, Italy, September 2012
Abstract Reviewer, American College of Cardiology Annual Meeting, 2012
Inaugural Member, Geriatric Cardiology Research Working Group, American College of Cardiology, 2012-2015
Member, NIA GEMSSTAR Study Section, January 2013
Member, NHLBI Pediatric Heart Failure Working Group, April 2013
Member, AHA Cardiac Bio Reg Study Section, October 2013-2015
Peer Evaluator, Center for Personalized Education for Physicians, Denver, Colorado, 2014
Ad Hoc member, VA CARD-B study section, December 2014 and 2015
Ad Hoc member, clinical pediatric and fetal study section, ZRG1 SBIB-V (82), June 2015, February 2016
Member, AHA National Vascular Strategic Focused Research Network (SFRN) Clinical and Population Study section, November, 2017
International Reviewer, American University of Beirut, Lebanon, Fall 2017 Grant program
Member, Fellows’ Research Oversight Committee, Pediatric Cardiology, Childrens’ Hospital Colorado, 2017-present
Member, Assistant to Associate Promotions Committee, Department of Medicine, University of Colorado Anschutz Medical Campus, 2019-present
Doctoral Committee Member:
Derek Smith 2003
Greta Hoetzer 2004
Gary VanGuilder 2006
Craig Emter 2006
Christian Westby 2009
Matthew Bell 2009
Erich Kushner 2010
Andrew Edwards 2010
Owen MacEneaney 2010
Kyle Diehl-Sutton 2015
Jamie Hijmans 2018
Tyler Bammert 2018
Comprehensive Committee Member:
Greta Hoetzer 2003
Craig Emter 2004
Gary VanGuilder 2004
Andrew Edwards 2007
Owen MacEneaney 2007
Christian Westby 2008
Erich Kushner 2009
Brian Weil 2009
Kyle Diehl-Sutton 2013
Jamie Hijmans 2016
Tyler Bammert 2016
Kelly Stockelman 2019
Peer Reviewer for:
The Journal of Applied Physiology
The American Journal of Physiology: Heart Circ; Endo and Metab; Cell.
Maturitas
Journal of Clinical Psychopharmacology
Clinical Physiology and Functional Imaging
Journal of Clinical Cardiology
Diabetologia
Frontiers in Physiology
Journal of the American Heart Association
Lancet
Editor Board Member:
Journal of Applied Physiology 2010-present
Frontiers in Physiology 2010-present
AJP: Heart Circ Physiol – Guest Editor 2019
Guest Lecture: Graduate Seminar KAPH 6640 ‘Pathophysiology of Ischemic Heart Disease and Congestive Heart Failure’
Guest Lecture: AED, the Undergraduate Medical Honors Society. Physician Career Description and Discussion
Guest Lecture: Undergraduate MCDB Club. Career Panel Discussion
Invited Lecture: Cardiology Research Conference, UCHSC, November 2007
Invited Lecture: Wardenburg Health Center, CME. “Syncope, Palpitations, Chest Pain—Things that make students go bump in the night”, March 2006
Invited Lecture: Teachers minicourse. Molecular, Cellular and Developmental Biology, CU Boulder July 2006
Invited Lecture: Junior League of Denver, “Preventing Heart Disease in Women”, February 2007
Invited Lecture: Wardenburg Health Center, CME. “Critical review of the Literature”, November 2007
Invited Moderator: American Federation for Medical Research, Annual Western Regional Meeting, Cardiovascular session, 2008-present
Invited Panelist: Introduction to Academic Careers, 4th Year Medical School Curriculum, UC Denver, February 2008
Invited Lecture: Cardiology Research Conference, February 2008
Invited Lecture: UCH Division of Geriatrics, Research Conference, February 2008
Invited Lecture: American Aging Association, National Conference, “Aging, Exercise and Endothelial Fibrinolytic Function”, June 2008
Invited Speaker: Northwestern Cardiovascular Young Investigators’ Forum, “Vascular Function and the Metabolic Syndrome in Older adults”, October 2008
Moderator: Cardiology II Session, Western Regional Meeting, American Federation of Medical Research, January 2009.
Invited Speaker: State-of-the-Art Lecture: Western Regional Meeting of the American Federation for Medical Research, “Exercise, Estrogen and Vascular Function”, January 2009
Invited Speaker: APS Sex Steroids and Gender in Cardiovascular-Renal Physiology and Pathophysiology Conference, “Sex-differences in Endothelin-1 Mediated Vasoconstrictor Tone in Middle-aged Adults”, July 2009
Invited Speaker: Northwestern Cardiovascular Young Investigators’ Forum, “Adaptation of the beta-Adrenergic System in Pediatric Heart Failure”, September 2009
Invited Speaker: UC Denver Cardiology Grand Rounds, “Fatty Acids and Cardiovascular Disease”, May 2010
Invited Speaker: Colorado State University, Department of Health and Exercise Science, 2010-11 Seminar Series, “Age-Related Differences in the Molecular Mechanisms of Heart Failure in Humans.” October 29, 2010
Invited Speaker: 8th Annual Women and Cardiovascular Disease Symposium. “Hormones and Heart Failure.” March 12, 2011.
Commencement Address: Integrative Physiology, UC Boulder, Winter Convocation, December 2011.
Moderator: Cardiology I Session, Western Regional Meeting, American Federation of Medical Research, January 2012.
Invited Speaker: 38th Annual Barbara Joyce Symposium, New Horizons of Cardiac Research: From Laboratory to Clinical Application. Colorado State University, February 2012.
Invited Speaker. European Society of Cardiology, Myocardial and Pericardial Disease working group symposium. “Florence International Symposium on Advances in Cardiomyopathies.” Talk title “Unique Myocardial Remodeling in Children with Heart Failure.” Florence, Italy, September 2012.
Guest Lecturer: Exercise Physiology course, UC Boulder, “Sudden Cardiac Death in Exercise”, March 14, 2013.
Invited Speaker: Vascular Biology Working Group, “Invasive Indicators of Vascular Health or Disease in Humans”, February 4, 2014.
Invited Speaker: CWHR ARCS Foundation visit, “Heart Disease in Women”, February 21, 2014.
Invited Speaker: CWHR community outreach at the Denver Country Club, “Heart Disease and Diabetes – How do these diseases affect women and men differently across the lifespan?”, March 2014.
Invited Speaker: 11th Annual Women and Cardiovascular Disease Symposium. “Heart Disease in Women.” March 1, 2014.
Guest Lecturer: Graduate Seminar series, UC Boulder, “Cardiovascular Disease and Aging”, December 3, 2014.
Invited Speaker: Cardiology Research Conference, UCD, “Age, Sex and Heart Failure”, February 9, 2015
Invited Speaker: CWHR program for Hind Financial Group, “Heart Disease and Women”, June 18, 2015
Invited Speaker: Physiology Seminar series, UCD, “Age, Sex and Heart Failure”, November 2, 2015
Invited Speaker: Cardiology Grand Rounds, University of Arizona, “Age and Heart Failure: What can we learn from Children”, March 25, 2016
Invited Speaker: European Society of Cardiology: Satellite Symposium: Targeting mitochondria to improve outcomes in heart failure, “Elamipretide improves mitochondrial activity in the failing human heart”, May 22, 2016, Florence, Italy.
Invited Speaker: Cardiology Research Conference, Pennsylvania State University College of Medicine, “Heart Failure in Children: Clinical Phenotypes to Molecular Mechanisms”, August 26, 2016.
Invited Speaker: Department of Medicine: Research and Innovation Conference, “Mitochondrial Function in the Human Heart”, February 9, 2017.
Invited Speaker: European Society of Cardiology: Satellite Symposium: A mitochondrial approach to heart failure, “Elamipretide improves mitochondrial activity in the failing human heart”, April 30, 2017, Paris, France.
Panel Member, AHA Early Career Session, How to get a K Award, AHA annual meeting, Anaheim, November 2017
Invited Faculty, 2018 GEMSTAR conference, “The impact of cognitive impairment across specialties”, March 2018
Invited Speaker: Cardiology Research Conference, UCD, “Beta-blockers for Hypertension: A Novel Look at the Vascular Endothelium”, January 13, 2020
Invited Speaker: Suter Science Seminar, Eastern Mennonite University, “Cardiology: One way to get there from here”, February 12, 2020
Undergraduate Student Trainees Current Position
Laura Edgerley-Gibb, MD Emergency Medicine Physician, Denver, CO
Natalia Flores, MD Gyn Onc, NYU
Jamie Schulz, DO Internal Medicine Resident, University of Cincinnati
Molly Taylor, PhD Postdoctoral Scientist, AstraZeneca, UK
Marilyn Ng, MD Plastic Surgeon, Temple University
Erin McCardle, PA Physician Assistant
Jamie Hijmans, PhD Medical Writer, Global Medical Writing & Translation
Kyle Diehl-Sutton, PhD Dental Student, University of Colorado Denver, Dental School
Scott Tarrant Undergraduate Student, UC Denver
Rob Van Dusen Undergraduate Student, Duke University
William Melhado Undergraduate Student, Middlebury College
Juliana Sucharov-Costa Professional Research Assistant, CU Anschutz
Brian Thomas Undergraduate Student, UC Boulder
Graduate/Postdoctoral Trainees Current Position
Derek Smith, PhD Associate Professor, University of Wyoming
Greta Hoetzer, PhD Executive Regional Scientific Manager, AstraZeneca
Gary Van Guilder, PhD Associate Professor, South Dakota State University
Jane Nydam, MD Pediatric Cardiologist, Rocky Mountain Pediatric Cardiology, Denver
Shayanne Lajud, MD ENT Resident, University of Puerto Rico
Christian Westby, PhD IRB Chair, Advarra
Michael Mestek, PhD Senior Program Manager, Medtronic
Erich Kushner, PhD Assistant Professor, University of Denver
Brian Weil, PhD Research Assistant Professor, University at Buffalo
Owen MacEneaney, PhD Medical Student, University of Ireland
Garrett Morgan, PhD Senior Fellow, University of Washington
Danielle (Templeton) Brunjes, PhD Clinical Trials Manager, Mount Sinai Health System
Stephanie Nakano, MD Assistant Professor, Children’s Hospital Colorado
Kathryn Chatfield, MD, PhD Assistant Professor, Children’s Hospital Colorado
Gloria Russell, MD Medical Assistant, Hospital Metropolitano de Santiago
Matthew Madsen, MS Educational Consultant, Moser Educational Services
Jonathan Grudis, MD Resident, University of Colorado School of Medicine
Kyle Diehl-Sutton, PhD Dental Student, University of Colorado Denver, Dental School
Elizabeth Medina, PhD Affiliate Faculty, Regis University, MSU, FRCC
Shane Nau, MD Resident, UC School of Medicine
Jamie Hijmans, PhD Free Lance Medical Writer
Kathleen Woulfe, PhD Assistant Professor, UC School of Medicine
Jennifer Jarvie, MD Cardiology Fellow, UC School of Medicine
Research:
Grants Pending:
Transformational Project award Miyamoto, PI (Stauffer co-I) Period: 1/1/20-12/31/22
Agency: AHA
“Targeting Mitochondria in Single Ventricle Heart Disease”
The general aim of this project is to determine the role of mitochondrial function on myocardial function in children with single ventricle heart disease.
R01 HL Moreau, PI (Stauffer, Co-I) Period: 4/1/20-3/31/25
Agency: NIH NIA
“Role of SIRT3 and Mitochondrial Dysfunction in Vascular Aging in Women”
The general aim of this project is to determine key biological mechanisms underlying accelerated vascular aging with the menopause transition and declines in estradiol (E2) in women.
Research Projects Ongoing:
Transformative Research Program, Stauffer, PI Period: 7/1/19-6/30/21
Agency: American Heart Association
“Bioenergetics and Myofibril Function in Pediatric Dilated Cardiomyopathy”
The general aim of this project is to identify novel mitochondrial interventions for heart failure in children.
R01 HL139968 Lipshulz, Sucharov, Myamoto, Shi MPI, (Stauffer, Co-I) Period: 2/17/18-1/31/22
Agency: NIH NHLBI
“Prognostic Significance of microRNA Expression in Children with Cardiomyopathy.”
The general aim of this project is to validate a laboratory test to predict myocardial recovery or need for heart transplant in children with dilated cardiomyopathy.
R01 HL135598 Stauffer, PI (MPI, DeSouza, Wright) Period: 12/20/16-12/19/20
Agency: NIH NHLBI
“Sleep and Blood Pressure-Related Endothelial Abnormalities”
The general aim of this project is to determine whether improving a sleep deficit improves vascular function in patients with elevated blood pressure.
R01 AG049762 Moreau, PI (Stauffer, Co-I) Period: 2/1/16-1/31/21
Agency: NIH NIA
“Cardiovascular Consequences of Hypogonadism in Men”
The general aim of this project is to determine cardiovascular effects of short-term testosterone deficiency.
R01 HL131458 DeSouza, Connick, Co-PI (Stauffer, Co-I) Period: 1/1/16-12/31/19
Agency: NIH NHLBI
“HIV-1, Insufficient Sleep and Vascular Endothelial Dysfunction”
The general aim of this project is to determine whether improving a sleep deficit improves vascular function in patients with HIV-1 infection.
R01HL126928 Miyamoto, PI, (Stauffer, Co-I) Period: 4/1/15-3/31/20
Agency: NIH NHLBI
“Myocardial Effects of Phosphodiesterase-5 Inhibition in Single Ventricle Heart Disease”
The general aim of this project is to determine the effects of PDE5 in the myocardium.
K08HL127294 Chatfield, PI (Stauffer, Mentor) Period: 4/5/15-3/31/20
Agency: NIH/NHLBI
“Cardiolipin Biosynthesis and Mitochondrial Energy Production in Pediatric Idiopathic Dilated Cardiomyopathy”
The general aim of this project is to determine mitochondrial function and energy metabolism in pediatric idiopathic dilated cardiomyopathy.
Research Projects Completed (Stauffer, PI):
R41 HL137564 Sucharov, PI, (Stauffer, Co-I) Period: 9/1/17-12/28/18 (NCE)
Agency: NIH NHLBI
“Non-invasive risk assessment tool for pediatric heart failure.”
The general aim of this project is to develop a laboratory test to predict myocardial recovery or need for heart transplant in children with dilated cardiomyopathy.
R01HL107715. Stauffer, PI Period: 12/1/11-11/30/17 (NCE)
Agency: NIH NHLBI
“Molecular and Functional Mechanisms of Pediatric Heart Failure”
The general aim of this project is to understand how the myocardial response to heart failure in children is different from the response in adults. Molecular, epigenetic, and trabeculae and sarcomere functional mechanisms will be addressed.
Advanced Industries Accelerator Grant, Miyamoto and Sucharov, PIs (Stauffer, Co-I) Period: 6/1/16-5/31/17
Agency: CU TTO/State of Colorado
“Biomarker test for pediatric Cardiac Allograft Vasculopathy”
The general aim of this project is to develop a diagnostic test to determine cardiac rejection in humans post heart transplant.
BYS-MD-72, Investigator Initiated Study. Stauffer, PI (MPI, DeSouza) Period: 1/1/12-12/30/17
Forest Laboratories, Inc.
“Nebivolol and Endothelial Regulation of Fibrinolysis (NERF Study)”
The goal of this study is to determine the influence of nebivolol on vascular endothelial tissue-type plasminogen activator release in adults with prehypertension.
Investigator Initiated award, Stauffer, PI Period: 12/1/15-11/30/17
Stealth Peptides, Inc.
“Bendavia and Mitochondria Function in Human Heart Failure: Phase II”
The general aim of this contract is to determine the influence of Bendavia on mitochondrial function in the explanted failing human heart.
3R01HL107715-01A1S1. Stauffer, PI Period: 10/1/12-9/30/16
Agency: NIH NHLBI
“Molecular and Functional Mechanisms of Pediatric Heart Failure”
The general aim of this project is to support a minority post-doctoral research fellow and determine the interaction between histone deacetylase 6 and GRK2 in heart failure.
BYS-MD-57, Investigator Initiated Study. Stauffer, PI (MPI, DeSouza) Period 6/1/11-5/31/16
Forest Research Institute, Inc.
“Nebivolol and the Endothelin (ET)-1 System (NETS Study)”
The goal of this study is to determine the influence of nebivolol on ET-1 mediated vascular endothelial tone in adults with prehypertension.
Mentored Junior Faculty Development Award. Chatfield, PI (Stauffer, Mentor) Period: 10/01/14-9/30/15
Agency: CU Center for Women’s Health Research
“Dysregulated Cardiolipin Biosynthesis and Altered Mitochondrial Energy Production in Pediatric Idiopathic Dilated Cardiomyopathy”
The general aim of this project is to determine whether there are sex differences in cardiac mitochondrial function in children with idiopathic dilated cardiomyopathy.
R01HL098052. DeSouza, PI (Stauffer, co-I) Period: 7/1/11-6/30/15
Agency: NIH NHLBI
“HIV-1, Exercise and Endothelial Function”
The general aim of this project is to determine whether exercise can improve the endothelial dysfunction associated with HIV-1 infection.
Investigator Initiated award, Stauffer, PI Period: 9/1/14-6/1/15
Stealth Peptides, Inc.
“Bendavia and Mitochondria Function in Human Heart Failure”
The general aim of this contract is to determine the influence of Bendavia on mitochondrial function in the explanted failing human heart.
3R01HL107715-03S1. Stauffer, PI Period: 7/22/14-7/21/15
Agency: NIH NHLBI
“Molecular and Functional Mechanisms of Pediatric Heart Failure”
The general aim of this project is evaluate sex differences in the failing human pediatric heart.
Colorado Biodiscovery and Evaluation Grant. Stauffer, PI (MPI, Miyamoto, Sucharov) Period 6/9/11-4/30/13
State of Colorado
Selective β1-adrenergic blockade in children with heart failure
The general aim of this project is to demonstrate in vivo benefit of beta1 selective adrenergic antagonism in an animal model of pediatric heart failure.
M-11-80. Chatfield, PI. (Stauffer, Mentor) Period: 1/2/12-5/1/13
Agency: NIH/NCRR Colorado CTSI (UL1 RR025790) Mentored Pilot Grant
“Cardiolipin Metabolism in Pediatric Heart Failure”
The general aim of this study is to determine cardiolipin abnormalities in the failing pediatric heart.
T32 HL007822 Buttrick, PI; Nakano, Trainee, Stauffer, mentor Period: 7/1/11-6/30/13
Agency: NIH/NHLBI
Phosphodiesterase System in Pediatric Heart Failure
The general aim of this study is to determine changes in phosphodiesterase expression with heart failure in children.
Junior Faculty Pilot Grant. Miyamoto, PI (Stauffer, co-I) Period: 1/2/12-1/1/13
Agency: NIH/NCRR Colorado CTSI (UL1 RR025790)
“cAMP Expression in Hypoplastic Left Heart Syndrome”
The general aim of this study is to determine cAMP levels in cardiac tissue from pediatric patients with hypoplastic left heart syndrome.
NORC Pilot Grant. Stauffer, PI Period 6/15/10-6/14/11
CU Center for Human Nutrition
“Dietary Linoleic Acid for the Treatment of Chronic Heart Failure”
The general aim of this project is to determine whether the omega-6 fatty acid, linoleic acid, improves cardiac and vascular function in patients with LV systolic dysfunction heart failure.
K08 HL080212. Stauffer, PI Period 2/1/07 – 1/31/12
Agency: NIH NHLBI
“Diet, Sex Steroids, and Cardiomyopathy”
The general aim of this project is to determine the mechanism behind the effect of sex and diet on sex-dependent differences in hypertrophic cardiac disease in a mouse model.
R21 HL097123. Stauffer, PI (MPI, Miyamoto, Sucharov) Period 9/1/09-8/31/11
Agency: NIH NHLBI
“Cardiac Beta-Adrenergic Adaptation in Pediatric Heart Failure”
The general aim of this project is to determine whether the beta-adrenergic receptor changes in response to heart failure are similar between children and adults.
0765482Z Beginning Grant-in-Aid. Stauffer, PI
Agency: American Heart Association Period 7/1/07-6/30/09
“Metabolic Syndrome and t-PA release in Older Adults”
The general aim of this project is to determine if endothelial t-PA release is impaired in older adults with the metabolic syndrome and if the hypothesized impairment is due to oxidant and inflammatory stress.
Pathway Medical Technologies Research Award. Stauffer, PI Period 7/1/06-12/30/07
Pathway Medical Technologies, Inc.
“Feasibility of Molecular Plaque Analysis”
The general aim of this project is to determine whether peripheral vascular plaque samples obtained by a percutaneous atherectomy device can be utilized to identify vascular gene and protein expression.
NIH Loan Repayment Award. Stauffer, PI Period: 06/01/03-5/31/05
Agency: NIH NHLBI
“Obesity/Insulin Resistance and Endothelial Dysfunction”
The general aim of this project is to determine if the decline in endothelial vasodilatory response to acetylcholine that is seen in the obese/insulin resistant population is due to a specific agonist related defect or a more general endothelial vasodilator abnormality.
Postdoctoral Fellowship. Stauffer, PI Period: 07/01/01-06/30/04
Agency: American Heart Association
“The Effect of Gender on Hypertrophic Cardiac Disease”
The general aim of this project is to determine if sex hormones contribute to the development of specific phenotypes of Hypertrophic Cardiomyopathy in a mouse model of the clinical disease.
Postdoctoral Research Fellowship. Stauffer, PI Period: 6/1/01-5/31/02 Returned: 6/30/01
NIH/NHLBI “The Effect of Gender on Hypertrophic Cardiac Disease”
The general aim of this project was to determine if sex hormones contribute to the development of specific phenotypes of Hypertrophic Cardiomyopathy in a mouse model of the clinical disease.
Research Projects Completed (Stauffer, Co-I/Consultant):
CCTSI Child and Maternal Health Junior Faculty Pilot Award (Stauffer, Co-I) Period 1/11/10-1/10/11
Agency: UCDenver CCTSI
“β-Adrenergic Receptor Regulation in Pediatric Heart Failure”
The general aim of this project is to determine whether myocardial cyclic AMP levels are different between adults and children with heart failure.
R01 HL077450 DeSouza, PI (Stauffer, Consultant) Period 7/1/04-6/30/09
NIH NHLBI
“Aging, Exercise, and Endothelin-1 Vasoconstrictor Tone”
The general aim of this project is to determine whether there is an increase in endothelin-1 vasoconstrictor activity associated with aging and whether physical activity improves the endothelial dysfunction associated with increased endothelin-1.
R01 HL076434 DeSouza, PI (Stauffer, Consultant) Period 6/1/04-5/31/09
NIH NHLBI
“Obesity/Insulin Resistance, Vitamin C and Endothelin-1”
The general aim of this project is to determine whether there is an increase in endothelin-1 vasoconstrictor activity associated with obesity/insulin resistance and whether antioxidant therapy is comparable to physical activity in improving the endothelial dysfunction associated with increased endothelin-1.
R21 HL88911. DeSouza, PI (Stauffer, Consultant) Period 7/1/07-6/30/09
Agency: NIH NHLBI
“HIV-1 Infection and Endothelial t-PA Release”
The general aim of this project is to determine whether HIV-1 infection impairs endothelial t-PA release in adult humans.
R01 HL075752 Annex, PI (Stauffer, Consultant) Period 9/25/03-7/31/08
NIH NHLBI
“Angiogenesis and Mechanisms of Exercise Training in PAD”
The general aim of this project is to determine the impact of exercise training on peripheral arterial disease.
U01 HL079160 Havrenek, PI DHHA, Steiner, PI UCHSC (Stauffer, Consultant) Period 9/1/04-8/31/09
NIH NHLBI
“Latinos Using Cardio Health Actions to Reduce Risk”
The general aim of this project is to improve the primary prevention of cardiovascular disease in Hispanics.
CFAR Pilot Project Award. DeSouza, PI (Stauffer, Co-I) Period 7/1/06-6/30/07
Agency: Colorado Center for Aids Research
“HIV-1 and Endothelial Progenitor Cells”
The general aim of this project is to determine whether HIV-1 impairs endothelial progenitor cell number and function in adult humans.
R01 HL068030 DeSouza, PI (Stauffer, Co.I.) Period: 8/1/02-7/31/06
NIH NHLBI/NIDDK Direct Costs: $225,000/yr
“Endothelial Abnormalities in Obesity/Insulin Resistance”
The general aim of this project is to determine if the decline in endothelial vasodilatory response to acetylcholine that is seen in the obese/insulin resistant population is due to a specific agonist related defect or a more general endothelial vasodilator abnormality.
Clinical Research Award. DeSouza PI (Stauffer, Co.I.) Period: 7/1/02-6/30/05
American Diabetes Association
Direct Costs: $100,000/yr
“Effects of Vitamin C Supplementation on Endothelial Function in Obese/insulin Resistant Adults”
The general aim of this project is to determine if oxidative stress contributes to the endothelial vasodilator abnormalities in the obese/insulin resistant population.
R03 AG023857. DeSouza, PI (Stauffer, Co.I) Returned in lieu of RO1 HL077450
NIH NIA
“Human Aging and Endothelin-1 Vasoconstrictor Activity”
The general aim of this project is to collect pilot data regarding the effect of endothelin-1on the vascular endothelium with age in healthy men and women.
R03 DK62061. DeSouza, PI (Stauffer, Co.I.) Period: 8/1/02-7/31/04
NIH NIDDK
“Obesity/Insulin Resistance and Endothelial t-PA Release”
The general aim of this project is to determine whether there is a decline in endothelial tissue plasminogen activator release in the obese/insulin resistant population and whether this hypothesized decline can be reversed with acute antioxidant therapy.
Grant-In-Aid. DeSouza, PI (Stauffer, Co.I.) Period: 7/1/02-6/30/04
American Heart Association
“Hormone Replacement and Fibrinolytic Capacity of the Vascular Endothelium”
The general aim of this project is to determine the effect of estrogen and estrogen receptor polymorphisms on the capacity of the vascular endothelium to release tissue plasminogen activator.
Clinical Research Award. DeSouza, PI (Stauffer, Medical Director) Period: 7/1/99-6/30/02
American Diabetes Association
“Effects of Exercise on Vascular Endothelial Health and Function in Older Obese/Insulin Resistant Adults”
The general aim of this project was to determine if regular aerobic exercise increases tonic and stimulated endothelial nitric oxide bioavailability and improves hemostatic function in older obese/insulin resistant adults
Beginning Grant-in-Aid. DeSouza, PI (Stauffer, Medical Director) Period: 7/1/00-6/30/02
American Heart Association
“Aging, Regular Physical Activity and Fibrinolytic Capacity of the Endothelium”
The general aim of this project was to determine if aging causes a decline in endothelial t-PA production sedentary and physically active adults.
Patents
US Application No. 13/817,969 “Selective Inhibition of beta1-adrenergic receptors for the treatment of pediatric heart failure” Granted: June 23, 2016.
US Application No. 14/203,022 “miRNAs as a prognostic biomarker in pediatric heart failure”
Provisional application filed: March 10, 2014.
“Prognosis of Vascular Disease, Graft Loss and Transplant Rejection in Pediatric Heart Transplant Recipients”
Provisional application filed: 11-10-2015
Peer Reviewed Publications
1. McPhaul, JC, AM Garcia, GC Sparagna, S Patel, CC Sucharov, BL Stauffer, SD Miyamoto, KC Chatfield. Alteration of Cardiolipin Biosynthesis and Remodeling in Single Right Ventricle Congenital Heart Disease. AJP: Heart Circ Physiol. In Revision.
2. Stockelman, KA, J Hijmans, T Bammert, JJ Greiner, BL Stauffer, CA DeSouza. Circulating Endothelial Cell-Derived Microvesicles are Elevated with Hypertension and Associated with Endothelial Dysfunction. Int J Card. In Review.
3. Nakano, SJ, JS Walker, LA Walker, X Li, Y Du, SD Miyamoto, CC Sucharov, AM Garcia, MB Mitchell, AV Ambardekar, BL Stauffer. Increased Myocyte Calcium Sensitivity in End-Stage Pediatric Dilated Cardiomyopathy. AJP: Heart Circ Physiol. 2019 Oct 18. doi: 10.1152/ajpheart.00409.2019. (PMID: 31625780)
4. Catenacci, VA, DM Ostendorf, Z Pan, K Bing, LT Wayland, E Seyoum, BL Stauffer, S Phelan, SA Creasy, AE Caldwell, HR Wyatt, DH Bessesen, EL Melanson. The Impact of Timing of Exercise Initiation on Weight Loss: An 18-Month Randomized Clinical Trial. Obesity. 27(11):1828-1838, 2019. (PMID: 31565869)
5. Kelley, GA, KS Kelley, BL Stauffer. Obesity and cardiovascular outcomes: Another look at a meta-analysis of mendelian randomization studies. J Investig Med. 2019 Jul 21. pii: jim-2019-001069. doi: 10.1136/jim-2019-001069. (PMID: 31331941)
6. Hijmans, JG, MV Levy, GM Lincenberg, KJ Diehl, JJ Greiner, BL Stauffer and CA DeSouza. Insufficient sleep is associated with a proatherogenic circulating microRNA signature. Experimental Physiology. 104(6):975-982, 2019. (PMID: 31016755)
7. Chatfield, KC*#, GC Sparagna*, S Chau, EK Phillips, AV Ambardekar, M Aftab, MB Mitchell, CC Sucharov, SD Miyamoto and BL Stauffer. Elamipretide Improves Mitochondrial Function in the Failing Human Heart. 4(2):147-157, 2019. JACC: Basic and Translational. *Co-First Authors. (PMID: 31061916, PMCID: PMC6488757) #2019 Young Author Achievement Award, ACC 2020.
8. Hijmans, J, T Bammert, P Kavlich, K Diehl, G Lincenberg, JJ Greiner, BL Stauffer, E Connick and CA DeSouza. Circulating microparticles are elevated in treated HIV-1 infection and are deleterious to endothelial cell function. JAHA. 8(4):e011134, 2019. . (PMID: 30779672, PMCID: PMC6405669)
9. Toni, LS*, AM Garcia*, DA Jeffrey, X Jiang, BL Stauffer, SD Miyamoto, and CC Sucharov. Optimization of Phenol-Chloroform RNA Extraction. MethodsX. May 30; 5:599-608, 2019. doi: 10.1016/j.mex.2018.05.011. eCollection 2018. (PMID: 29984193, PMCID: PMC6031757)
10. Woulfe, KC, S Chau, C Wilson, S Nau, EK Phillips, S Zang, C Tompkins, CC Sucharov, SD Miyamoto, BL Stauffer, Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs. Am J Physiol Heart Circ Physiol. Oct 1; 315(4):H1051-H1062, 2018. doi: 10.1152/ajpheart.00061.2018 (PMID: 30028197, PMCID: PMC6230911).
11. Garcia, AM, SJ Nakano, A Karimpour-Fard, K Nunley, P Nelson, NM Stafford, BL Stauffer, CC Sucharov, and SD Miyamoto. Phosphodiesterase-5 is elevated in failing single ventricle myocardium and affects cardiomyocyte remodeling in vitro. Circ HF. Sep; 11(9):e004571, doi: 10.1161/CIRCHEARTFAILURE.117.004571, 2018 (PMID: 30354365, PMCID: PMC6206883).
12. Mariner, PD, A Korst, A Karimpour-Fard, BL Stauffer, SD Miyamoto, CC Sucharov. Improved detection of circulating miRNAs in serum and plasma following rapid heat/freeze cycling. MicroRNA. Apr 16, 2018. doi: 10.2174/2211536607666180416152112 (PMID: 29658445, PMCID: PMC6198569).
13. Hijmans, J, T Bammert, P Kavlich, K Diehl, G Lincenberg, JJ Greiner, BL Stauffer, and CA DeSouza. Influence of overweight and obesity on circulating inflammation-related microRNA. MicroRNA. 7(2): 148-154, 2018. doi: 10.2174/2211536607666180402120806 (PMID: 29607782).
14. Hijmans, J, K Diehl, T Bammert, P Kavlich, G Lincenberg, JJ Greiner, BL Stauffer, and CA DeSouza. Association between hypertension and circulating vascular-related microRNA. J Human Hypertension. Jun; 32(6):440-447, 2018. doi: 10.1038/s41371-018-0061-2 (PMID: 29615793, PMCID: PMC6026553).
15. Stauffer, BL, CA Dow, KJ Diehl, TD Bammert, JJ Greiner, and CA DeSouza. Nebivolol, but not metoprolol, treatment improves endothelial fibrinolytic capacity in adults with elevated blood pressure. Journal of the American Heart Association, Nov 9; 6(11). Pii e007437. doi: 10.1161/JAHA.117.007437, 2017 (PMID: 29122812, PMCID: PMC5721799).
16. Nakano, SJ, AK Siomos, AM Garcia, H Nguyen, M SooHoo, C Galambos, K Nunley, BL Stauffer, CC Sucharov, SD Miyamoto. Fibrosis-related gene expression in single ventricle heart disease. J Pediatrics, Dec; 191:82-90.e2, 2017 (PMID: 29050751, PMCID: PMC5705574).
17. Bain, AR, BR Weil, KJ Diehl, JJ Greiner, BL Stauffer, CA DeSouza. Insufficient sleep is associated with impaired nitric oxide-mediated endothelium- dependent vasodilation. Atherosclerosis, Oct;265:41-46. doi: 10.1016/j.atherosclerosis.2017.08.001, 2017 (PMID: 28846879).
18. Dow, C, BL Stauffer, D Brunjes, JJ Greiner, and CA DeSouza. Regular aerobic exercise reduces endothelin-1 mediated vasoconstrictor tone in overweight and obese adults. Experimental Physiology, Sep 1;102(9):1133-1142, 2017 (PMID: 28635124).
19. Tatman, P*, KC Woulfe*, A Karimpour-Fard, DA Jeffrey, J Jaggers, JC Cleveland, K Nunley, MRG Taylor, SD Miyamoto, BL Stauffer#, CC Sucharov#. Pediatric dilated cardiomyopathy hearts display a unique gene expression profile. JCI Insight, July 20; 2(14), 2017 pii: 94249. doi: 10.1172/jci.insight.94249 (PMID: 28724804, PMCID: PMC5518568). *Co-First Authors, #Co-corresponding Authors.
20. Bammert, T, J Hijmans, P Kavlich, G Lincenberg, W Reiakvam, R Fay, J Greiner, BL Stauffer, CA DeSouza. Influence of sex on the number of circulating endothelial microparticles and microRNA expression in middle-aged adults. Experimental Physiology, 102(8):894-900, 2017 (PMID: 28568648).
21. Jiang, X, J Sucharov-Costa, BL Stauffer, SD Miyamoto, CC Sucharov. Exosomes from pediatric dilated cardiomyopathy patients modulate a pathological response in cardiomyocytes. Am J Physiol Heart Circ Physiol, 312(4):H818-H826, 2017 (PMID: 28130338, PMCID: PMC5407162).
22. Held, N, N Little, MJ Krantz, BL Stauffer. Refractory cardiogenic shock from right ventricular infarction successfully managed with inhaled epoprostenol. Am J Case Reports, 18:271-275, 2017 (PMID: 28298620, PMCID: PMC5363174).
23. Brown, DA, JB Perry, ME Allen, HN Sabbah, BL Stauffer, SR Shaikh, JGF Cleland, WS Colucci, J Butler, AA Voors, SD Anker, B Pitt, B Pieske, G Filippatos, SJ Greene, M Gheorghiade. Mitochondrial function as a therapeutic target in heart failure. Nature Rev Cardiology, 14(4):238-250, 2017 (PMID: 28004807, PMCID: PMC5350035).
24. Medina, E, CC Sucharov, P Nelson, SD Miyamoto, BL Stauffer. Molecular changes in children with heart failure undergoing LVAD therapy. J Pediatr, 182:184-189.e1, 2017 (PMID: 27908653, PMCID: PMC5328921).
25. Woulfe, KC, AK Siomos, H Nguyen, M SooHoo, C Galambo, BL Stauffer, CC Sucharov, SD Miyamoto. Fibrosis and fibrotic gene expression in pediatric and adult patients with idiopathic dilated cardiomyopathy. J Card Failure, 23(4):314-324, 2017 (PMID: 27890770, PMCID: PMC5380509).
26. Nakano, SJ, J Sucharov, R Van Dusen, M Cecil, K Nunley, ST Wickers, BL Stauffer, SD Miyamoto, CC Sucharov. Cardiac adenylyl cyclase and phosphodiesterase expression profiles vary by age, disease, and chronic phosphodiesterase inhibitor treatment. J Card Failure, 23(1):72-80, 2017 (PMID: 27427220, PMCID: PMC5384997).
27. Dow, CA, GM Lincenberg, JJ Greiner, BL Stauffer, CA DeSouza. Endothelial vasodilator function in normal-weight adults with metabolic syndrome. Applied Physiology, Nutrition, and Metabolism, 41(10):1013-1017, 2016 (PMID: 27643673).
28. Diehl, KJ, BL Stauffer, CA Dow, TD Bammert, DL Templeton, JJ Greiner, CA DeSouza. Chronic nebivololol treatment suppresses endothelin-1-mediated vasoconstrictor tone in adults with elevated blood pressure. Hypertension, 67(6):1196-204, 2016 (PMID: 27113048, PMCID: PMC4871319).
29. Dow, CA, DL Templeton, GM Lincenberg, JJ Greiner, BL Stauffer, CA DeSouza. Elevations in C-reactive protein and endothelin-1 system activity in humans. Life Sci, 159:66-70, 2016 (PMID: 26685760, PMCID: PMC4903088).
30. Stauffer, BL, K Dockstader, G Russell, J Hijmans, L Walker, M Cecil, K Demos-Davies, A Medway, TA McKinsey, CC Sucharov. Transgenic over-expression of YY1 induces pathologic cardiac hypertrophy in a sex-specific manner. Biochemical and Biophysical Research Communications, 462(2):131-137, 2015 (PMID: 25935483, PMCID: PMC4449792).
31. Dow, CA, BL Stauffer, JJ Greiner, CA DeSouza. Influence of habitual high dietary fat intake on endothelium-dependent vasodilation. Applied Physiology, Nutrition and Metabolism, 40(7):711-5, 2015 (PMID: 26058441, PMCID: PMC4864433).
32. Miyamoto, SD, A Karimpour-Fard, V Peterson, SR Auerbach, KR Stenmark, BL Stauffer, CC Sucharov. Circulating miRNA as a biomarker for recovery in pediatric dilated cardiomyopathy. Journal of Heart and Lung Transplantation, 34(5):724-33, 2015 (PMID: 25840506).*2015 Best paper of the year International Society of Heart and Lung Transplantation*
33. Konhilas J, H Chen, E Luczak, L McKee, J Regan, P Watson, B Stauffer, Z Khalpey, T Mckinsey, T Horn, B LaFleur, L Leinwand. Diet and sex modify exercise and cardiac adaptation in the mouse. Am J Physiol Heart Circ Physiol, 308:H135-45, 2015 (PMID: 25398983, PMCID: PMC4338936)
34. Diehl, KJ, BR Weil, JJ Greiner, KP Wright, BL Stauffer, CA DeSouza. Impaired endogenous fibrinolytic capacity in prehypertensive men. J Human Hypertension, 2015 Jan 8. Doi: 10/1038/jhh.2014.120 (PMID: 25566873, PMCID: PMC4762274).
35. Nakano, SJ, SD Miyamoto, M Movsesian, P Nelson, BL Stauffer, CC Sucharov. Age-related differences in phosphodiesterase activity and effects of chronic phosphodiesterase inhibition in idiopathic dilated cardiomyopathy. Circ HF, 8(1):57-63, 2015 (PMID: 25278000, PMCID: PMC4303519).
36. Sucharov, CC, J Sucharov-Costa, A Karimpour-Fard, K Nunley, BL Stauffer, SD Miyamoto. miRNA expression in hypoplastic left heart syndrome. J Cardiac Failure, 21:83-8, 2015 (PMID: 25291457, PMCID: PMC4276459).
37. Diehl, KJ, JJ Greiner, BL Stauffer, CA DeSouza. Endothelin-1 system activity in adults with borderline high LDL-cholesterol. Artery Res, 8:115-8, 2014 (PMID: 25267931, PMCID: PMC4175439).
38. Dow, CA, BL Stauffer, JJ Greiner, CA DeSouza. Influence of dietary saturated fat intake on endothelial fibrinolytic capacity. Am J Card, 114:783-8, 2014 (PMID: 25052545, PMCID: PMC4357274).
39. Chatfield, KC, GC Sparagna, CC Sucharov, SD Miyamoto, RD Sobus, J Hijmans, BL Stauffer. Dysregulation of cardiolipin biosynthesis in pediatric and adult heart failure. JMCC, 74:251-259, 2014 (PMID: 24937604, PMCID: PMC4114989).
40. Rocha, NG, DL Templeton, JJ Greiner, BL Stauffer, CA DeSouza. Metabolic syndrome and endothelin-1 mediated vasoconstrictor tone in overweight/obese adults. Metabolism, 63:951-6, 2014 (PMID: 24856242, PMCID: PMC4074589).
41. Burns, KM, BJ Byrne, BD Gelb, JR Kaltman, B Kuhn, LA Leinwand, S Mital, GD Pearson, M Rodefeld, JW Rossano, BL Stauffer, MD Taylor, JA Towbin, AN Redington. New Targets for Pediatric Heart Failure: Report from a National Heart Lung and Blood Institute Working Group. Circulation, 130:79-86, 2014 (PMID: 24982119, PMCID: PMC4554711).
42. Miyamoto, SD, BL Stauffer, J Polk, A Medway, M Friedrich, K Haubold, V Peterson, K Nunley, P Nelson, R Sobus, KS Stenmark, CC Sucharov. Gene expression and beta-adrenergic signaling are altered in hypoplastic left heart syndrome. Journal of Heart and Lung Transplantation, 33:785-793, 2014 (PMID: 24793904, PMCID: PMC4111994).
43. Miyamoto, SD*, BL Stauffer*#, S. Nakano, R Sobus, K Nunley, P Nelson, CC Sucharov. Beta-adrenergic adaptation in paediatric idiopathic dilated cardiomyopathy. Eur Heart J. 35(1):33-41, 2014 (PMID: 22843448, PMCID: PMC3877432).
*Authors contributed equally, #Corresponding Author.
44. Fasing, KA, B Nissan, JJ Greiner, BL Stauffer, CA DeSouza. Influence of elevated levels of c-reactive protein on circulating endothelial progenitor cell function. Clinical and Translational Science, 7:137-140, 2014 (PMID: 24422709, PMCID: PMC4113468).
45. Sucharov, CC, J Hijmans, RD Sobus, SD, Melhado, WFA, Miyamoto, BL Stauffer. Beta adrenergic receptor antagonism in mice: a model for pediatric heart disease. Journal of Applied Physiology, 115:979-987, 2013 (PMID: 23887897, PMCID: PMC3798823).
46. Moreau, KL, BL Stauffer, WM Kohrt, DR Seals. Essential role of estrogen for improvements in vascular endothelial function with endurance exercise in postmenopausal women. Journal of Clinical Endocrinology & Metabolism, 98:4507-4515, 2013 (PMID: 24092827, PMCID: PMC3816259).
47. Diehl, K, DL Templeton, J Ma, BR Weil, JJ Greiner, BL Stauffer, CA DeSouza. Impaired fasting plasma glucose is associated with increased endothelin-1 vasoconstrictor tone. Atherosclerosis 229:130-3, 2013 (PMID: 236430512, PMCID: PMC3726033).
48. Stauffer, BL, G Russell, K Nunley, SD Miyamoto, CC Sucharov. miRNA Expression in the pediatric failing human heart. J Mol Cell Cardiol. 57:43-6, 2013 (PMID: 23333438, PMCID: PMC3694420).
49. Weil, BR, JJ Greiner, BL Stauffer, CA DeSouza. Self-reported habitual Short sleep duration is associated with endothelial fibrinolytic dysfunction: A preliminary report. Sleep 36:183-8, 2013 (PMID: 23372265, PMCID: PMC3543061).
50. Diehl, KJ, BR Weil, JJ Greiner, BL Stauffer, CA DeSouza. White blood cell count and endothelin-1 vasoconstrictor tone in middle-aged and older adults. Artery Research 6:65-70, 2012 (PMID: 23908675, PMCID: PMC3727287).
51. Haines CD, ED Luczak, PA Harvey, KK Barthel, JP Konhilas, PA Watson, BL Stauffer, LA Leinwand. Estrogenic compounds are not always cardioprotective and can be lethal in males with genetic heart disease. Endocrinology 153:4470-9, 2012 (PMID: 22778230, PMCID: PMC3423614).
52. Gavin, KM, C Jankowski, WM Kohrt, BL Stauffer, DR Seals, KL Moreau. Hysterectomy is associated with large artery stiffening in estrogen-deficient postmenopausal women. Menopause 19:100-7, 2012 (PMID: 22692329, PMCID: PMC3428437).
53. Diehl, KJ, BL Stauffer, JJ Greiner, BR Weil, CA DeSouza. Nitric oxide-mediated endothelium-dependent vasodilation is impaired with borderline high LDL-cholesterol. Clinical and Translational Science 5:21-26, 2012 (PMID: 22376252, PMCID: PMC5439912).
54. Weil BR, CM Westby, JJ Greiner, BL Stauffer, CA DeSouza. Elevated endothelin-1 vasoconstrictor tone in prehypertensive adults. Canadian J Cardiology 28:347-353, 2012 (PMID: 22244775).
55. Weil BR, CM Westby, GP Van Guilder, JJ Greiner, BL Stauffer, CA DeSouza. Enhanced endothelin-1 system activity with overweight and obesity. AJP: Heart Circ. 301:H689-95, 2011 (PMID: 21666117, PMCID: PMC3191085).
56. Weil BR, BL Stauffer, ML Mestek, CA DeSouza. Influence of abdominal obesity on vascular endothelial function in overweight/obese adult men. Obesity 19:1742-1746, 2011 (PMID: 21738236).
57. Weil BR, EJ Kushner, KJ Diehl, JJ Greiner, BL Stauffer, CA DeSouza. CD31+ T cells, endothelial function and cardiovascular risk. Heart Lung Circ. 20:659-662, 2011 (PMID: 21767986, PMCID: PMC3176953).
58. Weil BR, JJ Greiner, CA DeSouza, BL Stauffer. Relation of C-reactive protein to endothelial fibrinolytic function in healthy adults. Am J Cardiology 108:1675-1679, 2011 (PMID: 21890088, PMCID: PMC3285466).
59. Weil BR, BL Stauffer, JJ Greiner, CA DeSouza. Prehypertension is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation in sedentary adults. Am J Hypertens. 24:976-981, 2011 (PMID: 21633396).
60. Kushner EJ, OJ MacEneaney, RG Morgan, BR Weil, JJ Greiner, BL Stauffer, CA DeSouza. Aging is associated with a pro-apoptotic endothelial progenitor cell phenotype. J Vasc Res. 48:408-414, 2011 (PMID: 21625174, PMCID: PMC3121552).
61. Luczak E, K Barthel, B Stauffer, J Konhilas, T Cheung, and L Leinwand. Remodeling the cardiac transcriptional landscape with diet. Physiol Genomics. 43:772-80, 2011 (PMID: 21487031, PMCID: PMC3121157).
62. Weil BR, OJ MacEneaney, JJ Greiner, BL Stauffer, CA DeSouza. Habitual short sleep duration and circulating endothelial progenitor cells. J Cardiovasc Dis Res. 2:110-114, 2011 (PMID: 21814415, PMCID: PMC3144618).
63. Stauffer BL#, R Sobus, CC Sucharov. Sex differences in cardiomyocyte connexin43 expression. J Cardiovasc Pharmacol. 58:32-39, 2011 (PMID: 21753256, PMCID: PMC3136750). #Corresponding Author.
64. Westby CM, BR Weil, JJ Greiner, BL Stauffer, CA DeSouza. Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilation in men. Clinical Science(Lond). 120:485-91, 2011 (PMID: 21143196).
65. Kushner EJ, BR Weil, OJ MacEneaney, RG Morgan, ML Mestek, GP Van Guilder, KJ Diehl, BL Stauffer, CA DeSouza. Human aging and CD31+ T cell number, migration, apoptotic susceptibility and telomere length. J Applied Physiol. 109:1756-1761, 2010 (PMID: 20864561, PMCID: PMC3006402).
66. Stauffer BL, CA DeSouza. Epigenetics: An emerging player in health and disease. Journal of Applied Physiology, 109:230-231, 2010 (PMID: 20489037).
67. Mestek ML, BR Weil, JJ Greiner, CM Westby, CA DeSouza, BL Stauffer. Osteopenia and endothelin-1-mediated vasoconstrictor tone in postmenopausal women. Bone, 47:542-545, 2010 (PMID: 20685405, PMCID: PMC2926281).
68. MacEneaney OJ, CA DeSouza, BR Weil, EJ Kushner, GP Van Guilder, M Mestek, JJ Greiner, BL Stauffer. Prehypertension and endothelial progenitor cell function. J. Human Hypertension. 25:57-62, 2010 (PMID: 20336149, PMCID: PMC2895004).
69. Weil BR, ML Mestek, CM Westby, GP Van Guilder, JJ Greiner, BL Stauffer, CA DeSouza. Short sleep duration is associated with enhanced endothelin-1 vasoconstrictor tone. Canadian Journal of Physiology and Pharmacology, 88:777-781, 2010 (PMID: 20725134).
70. Kushner EJ, GP Van Guilder, OJ MacEneaney, JJ Greiner, JN Cech, BL Stauffer, CA DeSouza. Aging and endothelial progenitor cell release of proangiogenic cytokines. Age and Aging. 1-4, 2009 (doi: 10.1093/ageing/afp244).
71. Stauffer BL, CM Westby, JJ Greiner, GP Van Guilder, CA DeSouza. Sex-differences in endothelin-1 mediated vasoconstrictor tone in middle-aged adults. AJP: Regul Integr Comp Physiol, 298:R261-5, 2010 (PMID: 19939973, PMCID: PMC2828167).
72. Mestek ML, CM Westby, GP Van Guilder, JJ Greiner, BL Stauffer, CA DeSouza. Regular aerobic exercise, without weight loss, improves endothelium-dependent vasodilation in overweight and obese adults. Obesity, 18:1667-9, 2010 (PMID: 20057377).
73. MacEneaney OJ, EJ Kushner, CM Westby, JN Cech, JJ Greiner, BL Stauffer, CA DeSouza. Endothelial progenitor cell function, apoptosis and telomere length in overweight/obese humans. Obesity. 18:1677-82, 2010 (PMID: 20057362).
74. MacEneaney OJ, Kushner EJ, Van Guilder GP, Greiner JJ, Stauffer BL, DeSouza CA. Endothelial progenitor cell number and colony-forming capacity in overweight and obese adults. Int J Obes (Lond). 33:219-225, 2009 (PMID: 19079361, PMCID: PMC2643316).
75. Kushner, E, GP Van Guilder, OJ MacEneaney, JN Cech, BL Stauffer, CA DeSouza. Aging and Endothelial Progenitor Cell Telomere Length in Healthy Men, Clinical Chemistry and Laboratory Medicine, 47: 47-50, 2009 (PMID: 19055473, PMCID: PMC2646422).
76. Stauffer, BL, EJ Kushner, T Wulfman, T Zeller, R Sobus, CM Westby. Transcriptional Regulation of β2-Microglobulin Demonstrated Via a Novel Genomic and Proteomic Analysis of Percutaneously Collected Peripheral Atheroma. Clinical and Translational Science, 1:240-244, 2008 (PMID: 20443854).
77. Stauffer, BL, OJ MacEneaney, EJ Kushner, JN Cech, JJ Greiner, CM Westby, CA DeSouza. Gender and Endothelial Progenitor Cell Number in Middle-Aged Adults. Artery Research, 2:156-160, 2008 (PMID: 19884973, PMCID: PMC2636711).
78. Van Guilder, GP, GL Hoetzer, JJ Greiner, BL Stauffer and CA DeSouza. Acute and chronic effects of vitamin C on endothelial fibrinolytic function in overweight and obese adult humans, J. Physiol., 586:3525-3535, 2008 (PMID: 18499730, PMCID: PMC2538820).
79. Stauffer, BL, CM Westby, CA DeSouza. Endothelin-1, Aging and Hypertension. Current Opinions in Cardiology, 23:350-355, 2008 (PMID: 18520719, PMCID: PMC2430763).
80. Van Guilder, GP BL Stauffer, JJ Greiner, and CA DeSouza. Impaired Endothelium-Dependent Vasodilation in Overweight and Obese Adult Humans is not Limited to Muscarinic Receptor Agonists, American Journal of Physiology:Heart, 294:H1685-H1692, 2008 (PMID: 18281379).
81. Van Guilder, GP, GL Hoetzer, JJ Greiner, BL Stauffer and CA DeSouza. Metabolic Syndrome and Endothelial Fibrinolytic Capacity in Obese Adults, American Journal of Physiology:Regul Integr Comp Physiol, 294:R39-44, 2008 (PMID: 17959703).
82. Van Guilder, GP, C Westby, JJ Greiner, BL Stauffer and CA DeSouza. Endothelin-1 Vasoconstrictor Tone Increases with Age in Healthy Men but can be Reduced by Regular Aerobic Exercise. Hypertension, 50:403-409, 2007 (PMID: 17576858).
83. Hoetzer, GL, GP Van Guilder, HM Irmiger, RS Keith, BL Stauffer, CA DeSouza. Aging, Exercise and Endothelial Progenitor Cell Colonogenic and Migratory Capacity in Men. Journal of Applied Physiology, 102:847-852, 2007 (PMID: 17158243).
84. Hoetzer, GL, OJ MacEneaney, HM Irmiger, R Keith, GP Van Guilder, BL Stauffer, CA DeSouza. Gender Differences in Circulating Endothelial Progenitor Cell Colony-Forming Capacity and Migratory Activity in Middle-Aged Adults. American Journal of Cardiology, 99:46-48, 2007 (PMID: 17196460, PMCID: PMC1894898).
85. Van Guilder, GP, GL Hoetzer, JJ Greiner, BL Stauffer and CA DeSouza. Influence of Metabolic Syndrome on Biomarkers of Oxidative Stress and Inflammation in Obese Adults. Obesity(Silver Spring), 14:2127-2131, 2006 (PMID: 17189537).
86. Van Guilder, GP, GL Hoetzer, DR Dengel, BL Stauffer and CA DeSouza. Impaired Endothelium-Dependent Vasodilation in Normotensive and Normoglycemic Obese Adult Humans. Journal of Cardiovascular Pharmacology, 47: 310-313, 2006 (PMID: 16495771).
87. Konhilas, JP, PA Watson, A Maass, DM Boucek, T Horn, BL Stauffer, SW Luckey, P Rosenberg, LA Leinwand. Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. Circulation Research, 98: 540-548, 2006 (PMID: 16439687).
88. Stauffer, BL, JP Konhilas, ED Luczak, LA Leinwand. Soy diet worsens heart disease in mice. The Journal of Clinical Investigation, 116(1): 209-216. 2006 (PMID: 16395406, PMCID: PMC1323247).
89. Van Guilder, GP, DT Smith, GL Hoetzer, BL Stauffer and CA DeSouza. Endothelial t-PA release is impaired in overweight and obese adults but can be improved by regular aerobic exercise. American Journal of Physiology:Endo, 289(5): E807-13, 2005 (PMID: 15985456).
90. DeSouza, CA, GP Van Guilder, JJ Greiner, DT Smith, GL Hoetzer, BL Stauffer. Basal endothelial nitric oxide release is preserved in overweight and obese adults. Obesity Research, 13(8): 1303-6, 2005 (PMID: 16129710, PMCID: PMC1361285).
91. Hoetzer, GL, GP Van Guilder, BL Stauffer, CA DeSouza. Estrogen receptor-alpha thymidine and adenine repeat polymorphism and endothelial fibrinolytic regulation in postmenopausal women. American Journal of Obstetrics and Gynecology, 193/2: 366-370, 2005 (PMID: 16098857).
92. Stauffer, BL, GL Hoetzer, GP Van Guilder, CA DeSouza. Gender differences in endothelial tissue-type plasminogen activator release in middle-aged adults. Journal of the American College of Cardiology, 45(9): 1547-1549, 2005 (PMID: 15862434).
93. Konhilas, JP, SW Luckey, A Maass, K Ikeda, BL Stauffer, EN Olson, LA Leinwand. Sex modifies exercise and cardiac adaptation in the mouse. American Journal of Physiology: Heart and Circulatory Physiology, 287: H2768-76, 2004 (PMID: 15319208, PMCID: PMC2637113).
94. Olsson, MC, BM Palmer, BL Stauffer, LA Leinwand, RL Moore. Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy. Circulation Research, 94: 201-207, 2004 (PMID: 14670849).
95. Stauffer BL, DT Smith, GL Hoetzer, JJ Greiner, CA DeSouza. Plasma C-reactive protein is not elevated in physically active postmenopausal women taking hormone replacement therapy. Journal of Applied Physiology, 96: 143-148, 2004 (PMID: 12949021).
96. Hoetzer GL, BL Stauffer, HM Irmiger, M Ng, DT Smith, CA DeSouza. Acute and chronic effects of oestrogen on endothelial tissue-type plasminogen activator release in postmenopausal women. Journal of Physiology, 551.2:721-728, 2003 (PMID: 12815179, PMCID: PMC2343226).
97. Smith, DT, GL Hoetzer, JJ Greiner, BL Stauffer, CA DeSouza. Endothelial release of tissue-type plasminogen activator in the human forearm: role of nitric oxide. Journal of Cardiovascular Pharmacology; 42(2):311-314, 2003 (PMID: 12883337).
98. Smith, DT, GL Hoetzer, JJ Greiner, BL Stauffer, CA DeSouza. Effects of ageing and regular aerobic exercise on endothelial fibrinolytic capacity in humans. Journal of Physiology, 546.1:289-298, 2003 (PMID: 12509496, PMCID: PMC2342457).
99. Hoetzer, GL, BL Stauffer, JJ Greiner, Y Casas, DT Smith, CA DeSouza. Influence of oral contraceptive use on endothelial t-PA release in healthy premenopausal women. American Journal of Physiology:Endo, 284:E90-E95, 2003 (PMID: 12388132).
100. Capell, WH, CA DeSouza, P Poirier, ML Bell, BL Stauffer, KM Weil, TL Hernandez, RH Eckel. Short-term triglyceride lowering with fenofibrate improves vasodilator function in subjects with hypertriglyceridemia. Arterioscler. Thromb. Vasc. Biol., 23:307-313, 2003 (PMID: 12588776).
101. Maass, A, JP Konhilas, BL Stauffer, LA Leinwand. From sarcomeric mutations to heart disease: understanding familial hypertrophic cardiomyopathy. Cold Spring Harbor Symposium on Quantitative Biology: The Cardiovascular System, 67:409-415, 2002 (PMID: 12858566).
102. Petersen, HH, J Choy, B Stauffer, FM Afshari, C Aalkjaer, L Leinwand, B McManus, I Laher. Coronary artery myogenic response in a genetic model of hypertrophic cardiomyopathy. Am. J. Physiology:Heart, 283:H2244-2249, 2002 (PMID: 12388227).
103. DeSouza CA, CM Clevenger, JJ Greiner, DT Smith, GL Hoetzer, LF Shapiro, BL Stauffer. Evidence for agonist specific endothelial vasodilator dysfunction with ageing in healthy humans. Journal of Physiology, 542.1: 255-262, 2002 (PMID: 12096067, PMCID: PMC2290401).
104. Dinenno FA, H Tanaka, BL Stauffer and DR Seals. Reductions in Basal Limb Blood Flow and Vascular Conductance with Human Ageing: Role for Augmented Alpha-Adrenergic Vasoconstriction. Journal of Physiology, 536.3:977-983, 2001 (PMID: 11691889, PMCID: PMC2278891).
105. Lankford, E, DH Korzick, BM Palmer, BL Stauffer, JY Cheung, RL Moore. Endurance exercise alters the contractile responsiveness of rat myocardium to extracellular Na+, and Ca2+. Med. Sci. Sports Exerc., 30(10)1502-9, 1998 (PMID: 9789850).
106. Stauffer, BL, BM Palmer, JY Cheung, RL Moore. Hypertension alters rapid cooling contractures in single rat cardiocytes. Am. J. Physiology, 272(3 Pt. 1):C1000-6, 1997 (PMID: 9124502).
Book Chapters
1. Stauffer BL and LA Leinwand. ‘Sex-differences in cardiac muscle and remodeling’. Principles of Sex-Based Differences in Physiology. Virginia Miller and Meredith Hay, Ed., Advances in Molecular and Cell Biology, Vol. 34, Chapter 10, pg. 131-145, 2004.
2. Miyamoto SD, BL Stauffer, CC Sucharov. ‘Molecular Pathways in Cardiomyopathies’. Cardioskeletal Myopathies in Children and Young Adults. JL Jeffries, BC Blaxall, JA Towbin, J Robbins, Ed., Elsevier, 2016.
Abstracts/Presentations
1. Jeffrey, DA, AM Garcia, GC Sparagna, BL Stauffer, SD Miyamoto, and CC Sucharov. Very Long Chain Ceramides are Increased in Pediatric Heart Failure and Promote Pathologic Remodeling. Keystone Symposium. Lipidomics and Functional Metabolic Pathways in Disease, March 2019.
2. Garcia, AM, GC Sparagna, DA Jeffrey, BL Stauffer, CC Sucharov and SD Miyamoto. Alterations in Sphingolipid Composition in the Pediatric Failing Single Ventricle Contribute to Pathological Myocardial Remodeling and Mitochondrial Dysfunction. Keystone Symposium. Lipidomics and Functional Metabolic Pathways in Disease, March 2019.
3. Sparagna, GC, HL Chapman, VL Warkins, GB Hardwick, DR Brown, EK Phillips, AM Garcia, D Jeffrey, I San-Millán, CC Sucharov, SD Miyamoto, BL Stauffer, and KC Chatfield. Cardiolipin Side Chain Composition May Control Oxidative Phosphorylation Through Lactate Signaling. Keystone Symposium. Lipidomics and Functional Metabolic Pathways in Disease, March 2019.
4. Garcia, AM, KC Chatfield, GC Sparagna, EK. Phillips, A Karimpour-Fard, BL Stauffer, CC Sucharov and SD Miyamoto. Metabolic Gene Expression and Mitochondrial Function are Altered in the Failing Single Ventricle Myocardium. Keystone Symposium. Mitochondrial Biology in Heart and Skeletal Muscle, January 2019.
5. Garcia, AM, KC Chatfield, GC Sparagna, EK Phillips, A Karimpour-Fard, BL Stauffer, CC Sucharov and SD Miyamoto. Metabolic Gene Expression and Mitochondrial Function are Altered in the Failing Single Ventricle Myocardium. National AHA meeting, November 2018.
6. Stockelman KA, Bammert TD, Dow CA, Diehl KJ, Garcia VP, Greiner JJ, Stauffer BL, DeSouza CA. Effects of Lowering Blood Pressure on Circulating Danger-Associated Molecular Patterns in Hypertensive Adults. April 2018. Presented at the Experimental Biology meeting, San Diego, CA. FASEB. 2018; 32(1 Suppl): A715.15. Presented at the annual Experimental Biology meeting, April 2018.
7. Goldthwaite ZA, Hijmans JG, Diehl KJ, Bammert TD, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Influence of Insufficient Sleep On Circulating microRNAs in Middle-Aged Adults. April 2018. Presented at the Experimental Biology meeting, San Diego, CA. FASEB. 2018; 32(1 Suppl): A905.5. Presented at the annual Experimental Biology meeting, April 2018.
8. Ostendorf, DM, Z Pan, SA Creasy, E Seyoum, K Bing, LT Wayland, BL Stauffer, S Phelan, HR Wyatt, DH Bessesen, EL Melanson, and VA Catenacci. The Impact of Timing of Exercise Initiation on Exercise Adherence and Long-term Weight Loss. The Obesity Society, ObesityWeek. Nov 2017.
9. Chatfield, KC, GC Sparagna, S Chau, MJ Bennet, AJ Chicco, J Van Hove, SD Miyamoto, BL Stauffer. Alterations in the Mitochondrial Supercomplex in Pediatric Dilated Cardiomyopathy. AHA BCVS meeting. July 2017.
10. Sparagna, GC, KC Chatfield, S Chau, DA Brown, E Phillips, N Stafford, A Ambardekar, A Korst, SD Miyamoto, CC Sucharov, BL Stauffer. Elamipretide, a cardiolipin-targeting peptide, decreases mitochondrial oxidant stress in the failing human heart. Oral Abstract. ESC Acute HF meeting. May 2017.
11. Perry, JB, EM Sullivan, ME Allen, AB Bandara, F Moukdar, BL Stauffer, SR Shaikh, DA Brown. Supercomplex-dependent improvements in mitochondrial function with the mitochondria-targeting peptide elamipretide. Oral Abstract. ESC Acute HF meeting. May 2017.
12. Hijmans JG, M Levy, JJ Greiner, BL Stauffer, E Connick, CA DeSouza. HIV-1 infection and circulating inflammation-related microRNAs. FASEB J 31:1015.33, 2017. Presented at the annual Experimental Biology meeting Chicago, IL, April, 2017.
13. Hijmans, JG, ML Levy, JJ Greiner, BL Stauffer, E Connick, CA DeSouza. Exercise, Oxidative Stress and Fibrinolytic Function in HIV-1 Infected adults. CROI. April 2017.
14. Runchey, S, KL Hildreth, AC Keller, TL Witten, E Crow, B Stauffer, WM Kohrt, RS Schwartz, KL Moreau. Oxidative Stress Contributes to Age-Associated Reduced Left Ventricular Diastolic Function in Men. APS Cardiovascular Aging meeting, August 2017.
15. Watanabe K, SR Auerbach, BL Stauffer, CC Sucharov, SD Miyamoto, A Karimpour-Fard, P Jone. MicroRNA-376a and 381 Correlate with Echocardiographic Indices of Graft Function in Pediatric Heart Transplant Recipients with Cardiac Allograft Vasculopathy. Oral abstract. International Society of Heart and Lung Transplantation annual Meeting, April 8, 2017.
16. Lincenberg, G, J Hijmans, P Kavlich, J Greiner, B Stauffer, E Connick, C DeSouza. Influence of HIV-1 on circulating vascular-related microRNAs. The Physiologist, 59:6, 2016, Poster 4.15. APS conference: Inflammation, Immunity and Cardiovascular Disease. August 24 to 27, 2016, Westminister, CO.
17. Fay, R, B Weil, J Greiner, B Stauffer, E Connick, C DeSouza. HIV-1, inflammation and endothelia dysfunction. The Physiologist, 59:6, 2016, Poster 4.16. APS conference: Inflammation, Immunity and Cardiovascular Disease. August 24 to 27, 2016, Westminister, CO.
18. Hijmans, J, T Bammert, P Kavlich, G Lincenberg, K Diehl, J Greiner, B Stauffer, C DeSouza. Obesity and circulating inflammation-related microRNAs. The Physiologist, 59:6, 2016, Poster 10.2. APS conference: Inflammation, Immunity and Cardiovascular Disease. August 24 to 27, 2016, Westminister, CO.
19. Chatfield, K, G Sparagna, S Chau, J Rodegheri-Brito, A Ambardekar, A Korst, S Miyamoto, C Sucharov, B Stauffer. MTP-131, a cardiolipin-targeting peptide, improves mitochondrial activity in the failing human heart. Rapid Fire Oral abstract at European Society of Cardiology, 3rd World Congress on Acute Heart Failure, May 2016, Florence, IT.
20. Woulfe, KC, S Chau, S Nau, LA Walker , C Tompkins, CC Sucharov , SD Miyamoto, and BL Stauffer. Age-specific differences in outcomes following isoproterenol (ISO)-induced sudden cardiac death in guinea pigs. Poster presentation at AHA Basic Cardiovascular Science Meeting, August 2016, Phoenix, AZ.
21. Hijmans, J, T Bammert, G Lincenberg, K Diehl, W Reiakvam, C Dow, J Greiner, B Stauffer, C DeSouza. Gender and Circulating Vascular Micro-RNAs in Middle-Aged Adults. Poster Presentation (4.10) at 2015 APS Conference, Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender, November 17 to 20, 2015 in Annapolis, MD.
22. Diehl, K, T Bammert, B Weil, J Greiner, B Stauffer, C DeSouza. Prehypertension and Endothelial Fibrinolytic Function in Middle-Aged Women. Poster Presentation (17.1) at 2015 APS Conference, Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender, November 17 to 20, 2015 in Annapolis, MD.
23. Bammert, T, J Hijmans, C Dow, W Reiakvam, G Lincenberg, J Greiner, B Stauffer, C DeSouza. Gender Differennces in Circulating Micro-Particles in Middle-Aged Adults. Poster Presentation (17.2) at 2015 APS Conference, Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender, November 17 to 20, 2015 in Annapolis, MD.
24. Auerbach S, Miyamoto SD, Karimpour-Fard A, Gralla J, Stauffer BL, Sucharov CC. Circulating miRNAs Can Predict Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients in a Sex-Dependent Manner. eAbstract Presentation, 2015 American Heart Association Annual Meeting, November 2015.
25. Dow, C, J Greiner, N Schuette, B Stauffer, C DeSouza. High Dietary Fat Intake is Associated with Enhanced Endothelin-1 Vasoconstrictor Tone. Poster Presentation (3.35) at 2015 APS Conference, 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, September 2 to 5, 2015 in Savannah, Georgia.
26. Dow, C, J Greiner, D Templeton, B Stauffer, C DeSouza. Vitamin C Supplementation Reduces ET-1 System Activity in Overweight and Obese Adults. Poster Presentation (3.36) at 2015 APS Conference, 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, September 2 to 5, 2015 in Savannah, Georgia.
27. Dow, C, J Greiner, K Diehl, B Stauffer, C DeSouza. Borderline-High Triglycerides and Endothelin-1 Vasoconstrictor Tone. Poster Presentation (3.37) at 2015 APS Conference, 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, September 2 to 5, 2015 in Savannah, Georgia.
28. Dow, C, J Greiner, G Lincenberg, B Stauffer, C DeSouza. C-Reactive Protein does not Influence Endothelin-1 System Activity in Healthy Adults. Poster Presentation (3.38) at 2015 APS Conference, 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, September 2 to 5, 2015 in Savannah, Georgia.
29. Changstrom B, Blaker B, Valle J, Stauffer B. A Prescription for Exercise Avoidance. Clinical Journal of Sports Medicine. Case Podium Presentations, 2015American Medical Society for Sports Medicine Annual Meeting, April 14 to 17, 2015 Volume 25(2), March 2015, p e32–e42.
30. Sucharov J, Sucharov CC, Miyamoto SD, Walker L, Stauffer BL. Hypertrophy Inducing Factor in Pediatric Idiopathic Dilated Cardiomyopathy Serum. Poster Presentation 2015 APS Experimental Biology Meeting, March 28 – April 1 in Boston, Massachusetts.
31. Stauffer, BL, Diehl KJ, Dow CA, Templeton DL, Greiner JJ, DeSouza CA. Chronic Nebivolol Treatment Supresses Endothelin-1-Mediated Vasoconstrictor Tone in Adults with Elevated Blood Pressure. Poster presentation at 2014 American Heart Association Annual Meeting, Chicago, IL, November 2014.
32. Grudis, JE, Chatfield KC, Sparagna GC, Hijmans J, Sobus RD, Sucharov CC, Miyamoto SD, Stauffer BL. Expression of Cardiolipin Biosynthesis and Remodeling Enzymes In Adult Heart Failure. Poster presentation at 2013 American College of Cardiology Meeting, San Francisco, California. The Journal of the American College of Cardiology, March; 61(Suppl 10): E698, 2013.
33. Grudis, JE, Chatfield KC, Sparagna GC, Hijmans J, Sobus RD, Sucharov CC, Miyamoto SD, Stauffer BL. Expression of Cardiolipin Biosynthesis and Remodeling Enzymes In Adult Heart Failure. Oral Plenary Presentation at 2013 American Federation for Medical Research Eastern Region Meeting, Washington, District of Columbia.
34. Grudis, JE, Chatfield KC, Sparagna GC, Hijmans J, Sobus RD, Sucharov CC, Miyamoto SD, Stauffer BL. Expression of Cardiolipin Biosynthesis and Remodeling Enzymes In Adult Heart Failure. Oral Presentation at 2013 American Physiological Society Pre-Experimental Biology Epithelial Transport Meeting, Boston, Massachusetts.
35. Grudis, JE, Chatfield KC, Sparagna GC, Hijmans J, Sobus RD, Sucharov CC, Miyamoto SD, Stauffer BL. Expression of Cardiolipin Biosynthesis and Remodeling Enzymes In Adult Heart Failure. Poster presentation at 2013 American Physiological Social Experimental Biology Meeting, Boston, Massachusetts.
36. Grudis, JE, Chatfield KC, Sparagna GC, Hijmans J, Sobus RD, Sucharov CC, Miyamoto SD, Stauffer BL. Expression of Cardiolipin Biosynthesis and Remodeling Enzymes In Adult Heart Failure. Oral presentation at 2013 International Society for Heart & Lung Transplantation Meeting, Montreal, Quebec. The Journal of Heart and Lung Transplantation, April; 32(Suppl 4): S97-S98, 2013.
37. Nakano, SJ, Movsesian M, Stauffer BL, Miyamoto SD, Sucharov CC. Regulation of Phosphodiesterase Activity in Pediatric Heart Failure. Presented at 2012 Paediatric Heart Failure Summit, Toronto, Ontario.
38. Chatfield, KC, Sparagna GC, Sucharov CC, Miyamoto SD, Sobus RD, Hijmans J, Stauffer BL. Dysregulation of Cardiolipin Biosynthesis in Pediatric Heart Failure. Presented at 2012 Paediatric Heart Failure Summit, Toronto, Ontario.
39. Ma J, Diehl KJ, Templeton DL, Greiner JJ, Stauffer BL, DeSouza CA. Impaired Fasting Glucose and Enhanced Endothelin-1 Vasoconstrictor Tone. FASEB Journal. 26; 869.17, 2012. Presented at Experimental Biology, San Diego, CA, April, 2012
40. Nissen BJ, Fasing KA, Greiner JJ, Stauffer BL, DeSouza CA. Effects Of Circulating C-Reactive Protein Levels On EPC Function. FASEB Journal. 26; 680.1, 2012. Presented at Experimental Biology, San Diego, CA, April, 2012.
41. Templeton DL, BR Weil, JJ Greiner, BL Stauffer, CA DeSouza. Regular aerobic exercise reduces endothelin-1 vasoconstrictor activity in overweight/obese adults. Journal of Clinical Hypertension, Apr; 14(Suppl 1): A52, 2012.
42. Hijmans JG, S Miyamoto, R Sobus, C Sucharov, B Stauffer. A Novel Animal Model of Pediatric Heart Failure. Journal of Investigative Medicine. 2012;60(1):135. Presented at the Western Regional Meeting of the American Federation of Medical Research.
43. Weil BR, Mestek ML, Greiner JJ, Stauffer BL, DeSouza CA. Increased endothelin-1 vasoconstrictor tone with prehypertension. The Journal of Clinical Hypertension. 2011; 13(1): A33. Presented at the American Society of Hypertension meeting.
44. Diehl KJ, BR Weil, JJ Greiner, BL Stauffer and CA DeSouza. Impaired Nitric Oxide-Mediated Endothelium-Dependent Vasodilation with Suboptimal LDL Cholesterol. Presented at the 2011 Experimental Biology Conference, Washington D.C.
45. Walker JS, LA Walker, SD Miyamoto, CC Sucharov and BL Stauffer. Skinned myocytes from children in heart failure show normal responses to PKA treatment. Circulation, 23 November, 2010; 122: A20803; oral.
46. Miyamoto SD, Stauffer BL, Haubold K, Nelson P, Medway A, Friedrich M, Stenmark KR, Sucharov CC. Beta-adrenergic Receptors are Downregulated in Hypoplastic Left Heart Syndrome. Circulation, 23 November, 2010; 122: A18448; oral.
47. MacEneaney OJ, EJ Kushner, J Stoner, BL Stauffer, E Connick, CA DeSouza. HIV-1 viral proteins gp120 and Tat impair endothelial progenitor cell function. American Physiological Society meeting: Inflammation, Immunity and Cardiovascular Disease, Westminster, CO, 2010. Poster.
48. MacEneaney OJ, EJ Kushner, JN Cech, RG Morgan, ML Mestek, BR Weil, JJ Greiner, BL Stauffer, E Connick, CA DeSouza. Influence of HIV-1 and HAART therapy on endothelial progenitor cell number and function. American Physiological Society meeting: Inflammation, Immunity and Cardiovascular Disease, Westminster, CO, 2010. Poster.
49. Weil BR, BL Stauffer, ML Mestek, JJ Greiner, E Connick, CA DeSouza. Impaired endothelium-dependent vasodilation with HIV-1 infection is due to oxidative stress. American Physiological Society meeting: Inflammation, Immunity and Cardiovascular Disease, Westminster, CO, 2010. Poster.
50. Diehl KJ, BR Weil, JJ Greiner, BL Stauffer, CA DeSouza. Higher white blood cell count is associated with enhanced endothelin-1 system activity in adult humans. American Physiological Society meeting: Inflammation, Immunity and Cardiovascular Disease, Westminster, CO, 2010. Poster.
51. Kushner EJ, RG Morgan, OJ MacEneaney, BR Weil, BL Stauffer, CA DeSouza. CD31+ T cells, endothelial function and cardiovascular disease risk. American Physiological Society meeting: Inflammation, Immunity and Cardiovascular Disease, Westminster, CO, 2010. Poster.
52. Weil BR, KJ Diehl, JJ Greiner, BL Stauffer, CA DeSouza. C-Reactive Protein and Endothelial Fibrinolytic Dysfunction. American Physiological Society meeting: Inflammation, Immunity and Cardiovascular Disease, Westminster, CO, 2010. Poster.
53. Kushner EJ, OJ MacEneaney, BR Weil, RG Morgan, ML Mestek, GP Van Guilder, JJ Greiner, KJ Diehl, BL Stauffer and CA DeSouza. Influence of Aging on Angiogenic T Cells. FASEB Journal. 24: 774.18. Presented at the annual Experimental Biology meeting, Anaheim, CA 2010.
54. Morgan RG, BR Weil, OJ MacEneaney, EJ Kushner, JJ Greiner, BL Stauffer and CA DeSouza. Short Sleep Duration and Endothelial Progenitor Cell Function. FASEB Journal. 24: 1058.13. Presented at the 2010 Experimental Biology Meeting, Anaheim, CA 2010.
55. Hijmans J, S Miyamoto, B Sobus, C Sucharov, B Stauffer. Development of a Mouse Model of Pediatric Heart Failure. Presented at the University of Colorado Denver, Research and Creative Activities Annual Symposium, April 30, 2010.
56. Miyamoto, S, C Sucharov, P Nelson, R Sobus, B Stauffer. Regulation of β-adrenergic receptors in pediatric heart failure. Journal of Cardiac Failure, 15:6(Suppl 1), S40, 2009. Presented at the Heart Failure Society annual meeting, Boston, MA, September 2009.
57. Mestek, M, Westby C, Van Guilder G, Greiner J, Stauffer B, DeSouza C. The metabolic syndrome is associated with greater ET-1 mediated vasoconstrictor tone in older men. The Physiologist 52:6 6.6, 2009. Presented at the 2009 American Physiological Society Conference, “ET-11: APS International Conference on Endothelin”.
58. Weil B, Mestek, M, Westby C, Van Guilder G, Greiner J, Stauffer B, DeSouza C. Short sleep duration is associated with greater endothelin-1 vasoconstrictor tone. The Physiologist 52:6 11.13, 2009. Presented at the 2009 American Physiological Society Conference, “ET-11: APS International Conference on Endothelin”.
59. Sucharov, C. S Miyamoto, P Nelson, R Sobus, B Stauffer. Regulation of beta-adrenergic receptors in pediatric heart failure. Circ. Res. 105:e31, 2009. Presented at the American Heart Association Basic Cardiovascular Science Conference 2009 – Molecular Mechanisms of Cardiovascular Disease, July, 2009.
60. Stauffer, BL, CM Westby, GP Van Guilder, JJ Greiner, CA DeSouza. Sex differences in endothelin-1 mediated vasoconstrictor tone in middle-aged adults. The Physiologist 52:6 9.2, 2009. Presented at the 2009 American Physiological Society Conference, “Sex Steroids and Gender in Cardiovascular-Renal Physiology and Pathophysiology”.
61. Mestek, M.L., Weil, B.R., Westby, C.M., Van Guilder, G.P., Greiner, J.J., Stauffer, B.L., and DeSouza, C.A. Osteopenia is associated with increased endothelin-1 vasoconstrictor tone in postmenopausal women. The Physiologist 52:6 9.6, 2009. Presented at the 2009 American Physiological Society Conference, “Sex Steroids and Gender in Cardiovascular-Renal Physiology and Pathophysiology”.
62. Mestek ML, Van Guilder GP, Westby CM, Greiner JJ, Stauffer BL, DeSouza, CA. Influence of abdominal adiposity on endothelial fibrinolytic capacity in overweight and obese adults. Diabetes, 58 (Supplement 1): A449, 2009. Presented at the American Diabetes Association Scientific Sessions, New Orleans, LA 2009.
63. Mestek ML, Van Guilder GP, Westby CM, Greiner JJ, Casas YG, Stauffer BL, DeSouza CA. Influence of abdominal adiposity on endothelium-dependent vasodilation in overweight and obese adults. Vascular Medicine. 2009;14:174
64. MacEneaney OJ, Westby CM, Kushner EJ, Cech JN, Stauffer BL, DeSouza CA. Influence of adiposity on endothelial progenitor cell function, apoptosis and telomere length in humans. Vascular Medicine. 2009;14:181
65. Stauffer, BL, GP Van Guilder, JJ Greiner, CA DeSouza, Endothelial tissue-type plasminogen activator release is reduced in older adults with metabolic syndrome. Presented at the Williams Symposium at the American Geriatrics Society Annual meeting, Chicago, IL, May 2009.
66. Stauffer, BL, GP Van Guilder, JJ Greiner, CA DeSouza, Endothelial tissue-type plasminogen activator release is reduced in older adults with metabolic syndrome. Circulation, 119:10, e291, P39, 2009. Presented at the Nutrition, Physical Activity and Metabolism conference, March 2009, Palm Harbor, FL.
67. Mestek, M.L., Stauffer, B.L., Westby, C.M., Weil, B.R., Van Guilder, G.P., Greiner, J.J., Connick, E., and DeSouza, C.A. Endothelial fibrinolytic capacity is impaired in HIV-1 infected men and is associated with oxidative stress. Abstract 728, Presented at the 16th Conference on Retroviruses and Opportunistic Infections, Montreal, Canada, 2009.
68. Van Guilder, G.P., Stauffer, B.L., Mestek, M.M., Westby, C.M., Greiner, J.J., Connick, E., and DeSouza, C.A. HIV-1 Infection is associated with accelerated vascular aging. Abstract 731, Presented at the 16th Conference on Retroviruses and Opportunistic Infections, Montreal, Canada, 2009.
69. Stauffer, BL, GP Van Guilder, JJ Greiner, CA DeSouza. Metabolic Syndrome and Endothelial Tissue-type Plasminogen Activator (t-PA) Release in Older Adults. Presented at the T. Franklin Williams Scholars Symposium, Austin, TX, January 2009.
70. Stauffer, BL, GP Van Guilder, JJ Greiner, CA DeSouza. Metabolic Syndrome Impairs Endothelial Tissue-type Plasminogen Activator (t-PA) Release in Older Adults. Presented at the Northwestern Cardiovascular Young Investigators’ Forum, October 4, 2008.
71. Stauffer BL, R Sobus. Sex Differences in Connexin 43 in a Model of Pathologic Hypertrophy. Circulation Research, 103:e45, 2008. Presented at the 2008 American Heart Association Basic Cardiovascular Sciences Conference: Heart Failure: Molecular Mechanisms and Therapeutic Targets.
72. Stauffer, BL, GP Van Guilder, JJ Greiner, CA DeSouza. Metabolic Syndrome and Endothelial Tissue-type Plasminogen Activator (t-PA) Release in Older Adults. Presented at the Williams Symposium at the American Geriatrics Society Annual meeting, Washington DC, May 2008.
73. EJ Kushner, GL Hoetzer, OJ MacEneaney, JJ Greiner, JN Cech, BL Stauffer, CA DeSouza. Aging and EPC release of proangiogenic factors. FASEB Journal. 22: 746.11. Presented at the annual Experimental Biology meeting, San Diego, CA 2008.
74. EJ Kushner, GP Van Guilder, OJ MacEneaney, JN Cech, AJ Zaug, BL Stauffer, CA DeSouza. Shortened telomere length in endothelial progenitor cells with age. Arteriosclerosis, Thrombosis and Vascular Biology, 28:e105, 2008. Presented at the annual Arteriosclerosis, Thrombosis and Vascular Biology meeting, Atlanta, GA, 2008.
75. EJ Kushner, RG Morgan, JN Cech, CM Westby, JJ Greiner, BL Stauffer, CA DeSouza. Aging is associated with a proapoptotic endothelial progenitor cell phenotype. Arteriosclerosis, Thrombosis and Vascular Biology, 28:e140, 2008. Presented at the annual Arteriosclerosis, Thrombosis and Vascular Biology meeting, Atlanta, GA, 2008.
76. OJ MacEneaney, EJ Kushner, CM Westby, JJ Greiner, JN Cech, BL Stauffer, CA DeSouza. Influence of adiposity on endothelial prognitor cell number and clonogenic capacity. Arteriosclerosis, Thrombosis and Vascular Biology, 28:e145, 2008. Presented at the annual Arteriosclerosis, Thrombosis and Vascular Biology meeting, Atlanta, GA, 2008.
77. GP Van Guilder, OJ MacEneaney, CM Westby, EJ Kushner, JJ Greiner, BL Stauffer, CA DeSouza. Prehypertension and circulating endothelial progenitor cell function. Arteriosclerosis, Thrombosis and Vascular Biology, 28:e146, 2008. Presented at the annual Arteriosclerosis, Thrombosis and Vascular Biology meeting, Atlanta, GA, 2008.
78. Van Guilder GP, CM Westby, JJ Greiner, BL Stauffer, CA DeSouza. Prehypertension and endothelium-dependent vasodilation. Vascular Medicine, 13:26, 2008. Presented at the annual meeting of the Society for Vascular Medicine, Minneapolis, MN, 2008.
79. Westby CM, GP Van Guilder, JJ Greiner, BL Stauffer, CA DeSouza. ET-1 mediated vasoconstrictor tone is equally elevated in overweight and obese adults. Vascular Medicine, 13:31, 2008. Presented at the annual meeting of the Society for Vascular Medicine, Minneapolis, MN, 2008.
80. Miyamoto, SD, P Lampe, BD Sobus, JE Nydam, BL Stauffer. Myocardial Gene Expression in Children with Dilated Cardiomyopathy. Presented at the AHA The Scientific Basis of Heart Failure in Children Conference, May 2008.
81. Stauffer, BL. R Sobus, E Kushner, C Westby, S Lajud, T Zeller, T Wulfman, CA DeSouza. Feasibility of molecular analysis of percutaneously collected peripheral atheroma, American Journal of Cardiology. The American Journal of Cardiology. 100(8):Suppl.: 83L, Presented at the Transcatheter Cardiovascular Therapeutics annual conference, Washington DC, October, 2007.
82. Stauffer, B, O MacEneaney, G Hoetzer, E Kushner, J Cech, C Westby, C DeSouza. Gender and Circulating Endothelial Progenitor Cell Number and Apoptosis. Sex and Gender in Cardiovascular-Renal Physiology and Pathophysiology, Austin, TX, August, 2007.
83. Konhilas, JP, ED Luczak, TH Cheung, BL Stauffer, LA Leinwand. Plant estrogens in the rodent diet negatively impact genetic heart disease in males. Circulation Research, 2007. Presented at the American Heart Association conference, Keystone CO, 2007.
84. MacEneaney OJ, GL Hoetzer, HM Irmiger, J Stoner, C Westby, JJ Greiner, BL Stauffer, CA DeSouza. Aging, Exercise and Endothelial Progenitor Cell Apoptosis. Circulation, 115, e257:P137, 2007. Presented at the American Heart Association 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention, Orlando FL, 2007.
85. Westby C, GP Van Guilder, JJ Greiner, Y Casas, BL Stauffer, CA DeSouza. Endothelin-1 vasoconstrictor activity contributes to impaired acetylcholine-mediated vasodilation in obesity. Circulation, 115, e242:091, 2007. Presented at the American Heart Association 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention, Orlando FL, 2007.
86. Van Guilder GP, GL Hoetzer, JJ Greiner, BL Stauffer and CA DeSouza. Influence of the metabolic syndrome on endothelium-dependent vasodilation in obese adults. Presented at the Metabolic Syndrome/metabolic risks: Implications for diabetes and cardiovascular risk reduction symposia, San Francisco CA, 2006, 57, P-11.
87. Van Guilder GP, GL Hoetzer, CM Westby, JJ Greiner, YG Casas, BL Stauffer, and CA DeSouza. Effects of vitamin C supplementation on endogenous endothelin-1 vasoconstrictor activity in overweight/obese adults. Presented at the Society for Vascular Medicine and Biology annual Scientific Sessions, Philadelphia, PA, 2006.
88. Westby CM, GP Van Guilder, JJ Greiner, YG Casas, BL Stauffer, and CA DeSouza. Endothelin receptor blockade improves endothelium-dependent vasodilation in older men. Presented at the Society for Vascular Medicine and Biology annual Scientific Sessions, Philadelphia, PA, 2006.
89. Van Guilder GP, JJ Greiner, Y Casas, BL Stauffer, CA DeSouza. Greater oxidative stress and inflammatory burden in obese adults with the metabolic syndrome. Arteriosclerosis, Thrombosis and Vascular Biology, 26(5):e84, p179, 2006. Presented at the annual Arteriosclerosis, Thrombosis and Vascular Biology meeting, Denver, CO, 2006.
90. Van Guilder GP, CM Westby, GL Hoetzer, JJ Greiner, Y Casas, BL Stauffer, DeSouza CA. Regular aerobic exercise alleviates the age-related increase in ednothelin-1 mediated vasoconstrictor tone. Arteriosclerosis, Thrombosis and Vascular Biology, 26(5):e99, p204, 2006. Presented at the annual Arteriosclerosis, Thrombosis and Vascular Biology meeting, Denver, CO, 2006.
91. Van Guilder GP, GL Hoetzer, JJ Greiner, Y Casas, BL Stauffer, DeSouza CA. Vitamin C supplementation improves endothelial t-PA release in obese adults. Arteriosclerosis, Thrombosis and Vascular Biology, 26(5):e103, p280, 2006. Presented at the annual Arteriosclerosis, Thrombosis and Vascular Biology meeting, Denver, CO, 2006.
92. Van Guilder GP, GL Hoetzer, JJ Greiner, YG Casas, BL Stauffer, and CA Desouza. Impaired endothelium-dependent vasodilation with obesity is not limited to muscarinic receptor agonists. Obesity Research Program Abstract Supplement, September 2005; 13: A5.
93. Van Guilder GP, GL Hoetzer, JJ Greiner, HM Irmiger, BL Stauffer, and CA Desouza. Influence of the metabolic syndrome on endothelial t-PA release in obese adults. Obesity Research Program Abstract Supplement, September 2005; 13: A125.
94. Hoetzer GL, HM Irmiger, GP Van Guilder, RS Keith, JJ Greiner, BL Stauffer, CA DeSouza. Beneficial effects of exercise on age-related reductions in endothelial progenitor cell number and migratory activity. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(5):e43-e109, 2005.
95. RS Keith, KM Westbrook, GL Hoetzer, GP Van Guilder, JJ Greiner, HM Irmiger, BL Stauffer, CA DeSouza. Effects of vitamin C supplementation on inflammatory markers in obese men. Presented at the 2004 American Diabetes Association Symposium: Inflammation, Diabetes and Cardiovascular Disease: Emerging Science and Clinical Implications, Chicago, IL.
96. GL Hoetzer, BL Stauffer, GP Van Guilder, JJ Greiner, CA DeSouza. Endothelial dysfunction and markers of systemic inflammation in obese adults. Presented at the 2004 American Diabetes Association Symposium: Inflammation, Diabetes and Cardiovascular Disease: Emerging Science and Clinical Implications, Chicago, IL.
97. GP Van Guilder, GL Hoetzer, DT Smith, JJ Greiner, YG Casas, HM Irmiger, BL Stauffer, CA DeSouza. Impaired endothelial fibrinolytic capacity with obesity is associated with oxidative stress. Presented at the annual Arteriosclerosis, Thrombosis and Vascular Biology Spring Conference, 2004; San Francisco, CA.
98. GL Hoetzer, GP Van Guilder, JJ Greiner, YG Casas, RS Keith, BL Stauffer, CA DeSouza. Impaired acetylcholine-mediated vasodilation in obesity is not due to reduced responsiveness or increased cholinesterase activity. Presented at the annual Arteriosclerosis, Thrombosis and Vascular Biology Spring Conference, 2004; San Francisco, CA.
99. GP Van Guilder, DT Smith, GL Hoetzer, HM Irmiger, BL Stauffer, CA DeSouza. Exercise without weight loss does not lower plasma C-reactive protein in obese adults. FASEB J: 2004. Presented at the annual Experimental Biology Spring Conference, 2004; Washington, D.C.
100. GL Hoetzer, CM Clevenger, DT Smith, JJ Greiner, BL Stauffer, CA DeSouza. Basal endothelial release of nitric oxide is preserved in uncomplicated obesity. FASEB J: 2004. Presented at the annual Experimental Biology Spring Conference, 2004; Washington, D.C.
101. Stauffer BL, GL Hoetzer, DT Smith, JJ Greiner, Y Casas, CA DeSouza. Influence of age and sex on the capacity of the endothelium to release tissue-type plasminogen activator. Circ, 108(Suppl. IV): IV-190, 2003. Presented at the 2003 AHA annual meeting, Orlando, FL.
102. Stauffer BL, GL Hoetzer, DT Smith, JJ Greiner, Y Casas, CA DeSouza. Influence of age and sex on the capacity of the endothelium to release tissue-type plasminogen activator. Presented at the 2003 AstraZeneca Cardiovascular Young Investigators Forum, Savannah, GA.
103. Stauffer BL, LA Leinwand. Diet is a potent sex-dependent modifier of cardiac hypertrophy in a mouse model of hypertrophic cardiomyopathy. Presented at the 2003 AHA meeting “Molecular mechanisms of growth, death, & regeneration in the myocardium”, Snowbird, UT.
104. NC Flores, BL Stauffer, LA Leinwand. GSK-3B activation is a potential mechanism for sex-dependent phenotypic variability in a mouse model of hypertrophic cardiomyopathy. Presented at the 2003 AHA meeting “Molecular mechanisms of growth, death, & regeneration in the myocardium”, Snowbird, UT.
105. Ng M, DT Smith, GL Hoetzer, HM Irmiger, JJ Greiner, Y Casas, BL Stauffer, CA DeSouza. Lack of an age-related increase in plasma C-reactive protein in endurance-trained men. Presented at the 2003 American College of Sports Medicine meeting in San Francisco, CA.
106. Vance J, DT Smith, GL Hoetzer, JJ Greiner, BL Stauffer, CA DeSouza. Capacity of the vascular endothelium to release t-PA: effect of gender. The FASEB Journal Presented at the 2003 Experimental Biology Annual meeting in San Diego, CA..
107. Smith DT, GL Hoetzer, JJ Greiner, BL Stauffer, CA DeSouza. Endothelial t-PA release: role of nitric oxide. The FASEB Journal Presented at the 2003 Experimental Biology Annual meeting in San Diego, CA.
108. Hoetzer GL, DT Smith, HM Irmiger, M Ng, BL Stauffer, CA DeSouza. Plasma C-reactive protein is elevated in premenopausal women taking oral contraceptives. The FASEB Journal Presented at the 2003 Experimental Biology Annual meeting in San Diego, CA.
109. Irmiger HM, GL Hoetzer, DT Smith, M Ng, Y Casas, JJ Greiner, BL Stauffer, CA DeSouza. Regular exercise improves endothelium-dependent vasodilation in obese adults. The FASEB Journal Presented at the 2003 Experimental Biology Annual meeting in San Diego, CA.
110. Hoetzer GL, BL Stauffer, HM Irmiger, DT Smith, CA DeSouza. Postmenopausal hormone replacement therapy and endothelial fibrinolytic capacity. ATVB, 23:a-8, 44, 2003. Presented at the 2003 AHA annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology in Washington, DC.
111. Smith DT, M Ng, GP Van Guilder, HM Irmiger, GL Hoetzer, BL Stauffer, CA DeSouza. Obesity-related impairment in endothelial t-PA release is reserved with exercise. ATVB, 23:a-22, P124, 2003. Presented at the 2003 AHA annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology in Washington, DC.
112. Stauffer BL, DT Smith, GL Hoetzer, JJ Greiner, CA DeSouza. Plasma C-reactive protein is not elevated in physically active postmenopausal women taking hormone replacement therapy. JACC, 41:6(Suppl. A):283A. Oral abstract, Presented at the 2003 American College of Cardiology annual meeting.
113. Stauffer BL, LP Edgerley, LA Leinwand. Age and gender-associated gene expression profiles in a mouse model of hypertrophic cardiomyopathy. Circulation, 106:19(Suppl.):II-208, 2002. Presented at the 2002 American Heart Association annual meeting.
114. Edgerley LP, BL Stauffer, LA Leinwand. Age-associated gene expression profiles in a mouse model of hypertrophic cardiomyopathy. Journal of Cardiac Failure, 8(4 Suppl.):S7, 2002. Presented at the 2002 Heart Failure Society of America annual meeting.
115. Smith DT, JJ Greiner, GL Hoetzer, BL Stauffer, CA DeSouza. Regular aerobic exercise prevents and reverses the age related decline in endothelial t-PA release. Circulation, 106:19(Suppl.):II-615, 2002. Presented at the 2002 American Heart Association annual meeting.
116. Smith DT, JJ Greiner, GL Hoetzer, Y Casas, BL Stauffer, CA DeSouza. Capacity of the vascular endothelium to release tissue-type plasminogen activator declines with age in healthy adult humans. The FASEB Journal 16:381.19, 2002. Presented at the 2002 Experimental Biology annual meeting in New Orleans, LA.
117. DeSouza CA, CM Clevenger, JJ Greiner, DT Smith, LF Shapiro, BL Stauffer. Impaired forearm endothelium-dependent vasodilation with age: evidence for an agonist-specific defect and not a more general endothelial vasomotor abnormality. The FASEB Journal 16:381.15, 2002. Presented at the 2002 Experimental Biology annual meeting in New Orleans, LA.
118. Hoetzer GL, DT Smith, JJ Greiner, M Ng,Y Casas, BL Stauffer, CA DeSouza. Influence of oral contraception on endothelial release of tissue-type plasminogen activator in vivo. The FASEB Journal 16:181.2, 2002. Presented at the 2002 Experimental Biology annual meeting in New Orleans, LA.
119. Greiner JJ, SD Blackett, Y Casas, GL Hoetzer, DT Smith, KL Moreau, BL Stauffer, CA DeSouza. Nitric oxide bioavailabity and hormone replacement therapy in postmenopausal women. The FASEB Journal 16:182.4, 2002. Presented at the 2002 Experimental Biology annual meeting in New Orleans, LA.
120. Smith DT, JJ Greiner, GL Hoetzer, Y Casas, BL Stauffer, CA DeSouza. Impaired endothelial t-PA release in obese/insulin resistant men. Presented at the American Diabetes Association Conference on Understanding the Metabolic Syndrome: Effect on Diabetes and Cardiovascular Disease, Tempe, AZ, 2001.
121. Stauffer BL, RL Moore, LA Leinwand. Sex Hormones Influence the Phenotype of Hypertrophic Cardiomyopathy in a Transgenic Mouse Model, Poster and Oral Abstract, Circulation 104(17 Suppl.):II-308, 2001, American Heart Association annual meeting, Anaheim, CA, November, 2001.
122. Capell WH, CA Desouza, KM Weil, BL Stauffer, P Poirier, RH Eckel. Triglyceride Lowering with Fenofibrate Improves Endothelial Vasodilator Function in Patients with Hypertriglyceridemia. Poster Abstract, Circulation 104(17 Suppl.):II-240, 2001. American Heart Association annual meeting, Anaheim, CA, November, 2001.
123. Stauffer BL, RL Moore, LA Leinwand. Testosterone influences the phenotype of hypertrophic cardiomyopathy in a sex dependent fashion in a transgenic mouse model. Abstract, The Physiologist, 44(4):274, 2001. Presented at the American Physiological Society, Genome and Hormones meeting October, 2001.
124. Stauffer BL, RL Moore, LA Leinwand. Sex Hormones Influence the Phenotype of Hypertrophic Cardiomyopathy in a Transgenic Mouse Model, Abstract, Journal of Cardiac Failure, 7(3, Suppl.2) 7, 2001. Presented at the Heart Failure Society of America annual meeting, Washington, DC, September, 2001.
125. Dinenno FA, H Tanaka, BL Stauffer, DR Seals Age-related reductions in basal limb blood flow and vascular conductance are mediated by increases in sympathetic-alpha adrenergic vasoconstrictor tone in healthy men. Abstract, The FASEB Journal 15(5 Suppl.):A1127, 2001. Poster abstract, the 2001 Experimental Biology meeting in Orlando, FL.
126. Hoetzer GL, BL Stauffer, JJ Greiner, YG Casas, DT Smith, CA DeSouza. Impaired endothelial vasodilator response to muscarinic but not beta-adrenoceptor stimulation in older men. Abstract, The FASEB Journal 15(5):886.8, 2001. Poster abstract, the 2001 Experimental Biology annual meeting in Orlando, FL.
127. Smith DT, JJ Greiner, GL Hoetzer, SD Blackett, YG Casas, BL Stauffer, CA DeSouza. Greater endothelial release of tissue plasminogen activator in endurance-trained vs. sedentary middle-aged and older men. Med. Sci. Sports Exerc., 33:S270, 2001. Presented at the 2001 American College of Sports Medicine annual meeting in Baltimore, MD.
128. WH Capell, P Poirier, CA DeSouza, KM Weil, BL Stauffer, RH Eckel. Effect of triglyceride lowering on endothelial dysfunction in patients with hypertriglyceridemia, Poster Abstract, the 2001 APOR meeting.
129. Stauffer, B., G. Mitro, and R.L. Moore. Chronic treadmill training does not influence ryanodine binding to rat myocardium. Med. Sci. Sports Exerc. 25(5 Suppl.):S98, 1993. Presented at the 1993 American College of Sports Medicine annual meeting.
130. Hass, E.E., J.T. Cope, B. Stauffer, J. Blauth, A.M. Semanchick, and R.L. Moore. Effect of endurance training and hypertension on rat cardiac ryanodine receptor number. Med. Sci. Sports Exerc. 24(5 Suppl.):S20, 1992. Presented at the 1992 American College of Sports Medicine annual meeting.
131. Moore, R.L., B.M. Palmer, E. Snell, B. Stauffer, R. Grange, and M.E. Houston. Manipulation of the 'P-light chain phosphate vs. isometric tension potentiation' relationship in mouse EDL muscle. Biophys. J. 55(2)263a, 1989. Presented at the 1989 Biophysical Society annual meeting.
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