Cardiomyopathy delays disease onset Targeting MRTF/SRF in ...

Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset 1Yao Xiong, 2Kenneth Bedi, 3Simon Berritt, 1 ... including dilated cardiomyopathy (DCM), is responsible for 5-20% of these deaths. About half of the cases of DCM are caused by mutations in the cytoskeletal proteins of the sarcomere (2, 3). Heart disease can lead to remodeling of the heart, characterized by ... ................
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