INFLAMMATORY DISEASES OF THE SKIN - Duke University
INFLAMMATORY DISEASES OF THE SKIN
M. Angelica Selim, M.D. Dermatopathology Unit Pathology Department
notice the 3 layers: epidermis, dermis and subcutaneous tissue
dermis (pink because it is collagen)
epidermis
fat (why white? lipids are dissolved when alcohol is added to the slide)
4 layers from bottom to top: - stratum basalis - stratum spinosum - stratum granulosum - stratum corneum
EPIDERMIS epidermis is like a wall with bricks. the bricks are the keratinocytes.
spinosumdesmosomes look like spines. form most of the epidermis.
keratinocytes die here.
Stratum corneum
Stratum spinosum (Lamellar granules)
filaggrin is the glue that keeps keratinocytes together.
Stratum granulosum (Filaggrin)
base: keratinocytes that
Stratum basalis
divide and will give origin to keratinocytes at the top
EPIDERMIS
KERATINOCYTES
Langerhans cells = immune system. APC cells of epidermis.
LANGERHANS CELLS
Merkel cells = neuroendocrine component. role not well known.
MERKEL CELLS
MELANOCYTES
"guys with the white cytoplasm". produce melanin "your natural sunscreen"
DERMIS collagenous tissue
SUBCUTANEOUS TISSUE fat. divided into lobules and septae. inflammation can include either lobules or septae.
ADNEXAL STRUCTURES
hair follicles with sebaceous glands hydtrate and protect your hair shaft.
sebaceous gland
apocrine gland"body odors" found in axilla for example
eccrine glandsmajor sweat gland found in virtually all skin
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