Queen Elizabeth National Spinal Injuries Unit for …
Queen Elizabeth National Spinal Injuries Unit for Scotland
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Scottish Centre for Innovation in Spinal Cord Injury
Cumulative Research Profile January 2018
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Queen Elizabeth National Spinal Injuries Unit for Scotland:
Research Profile 2018
Research in basic sciences, clinical treatment and prevention including translational approaches is a fundamental and embedded function of the spinal injuries unit. The ultimate aim is to act as a host and supporter of all scientists who can have a positive impact on the care of the traumatic spinal cord injured.
We have set up SCI ².The Scottish Centre for Innovation in Spinal Cord Injury as an umbrella group to support translational research in a clinical setting. The unit is supported by Glasgow University, whose Centre for Rehabilitation Engineering is based in the SRIF and GRPE funded Research Mezzanine.
It is envisaged that the unit acts as an embedded research micro site within the NHS to promote research and to provide access and stimulation for clinicians, patients and researchers to work together. The group conducts research in all areas of spinal cord injury from clinical review and outcome through understanding and promoting neural repair and regeneration to active intervention assessment and treatment strategies all based on basic science. The research is patient orientated and extends from harvesting and growing olfactory stem cells to robotic walking and brain computer interfacing. Psychological studies and the impact of disability are equally important. Spinal Injuries Scotland is a collaborative partner within Scotland and the unit has links with ISRT, SIA, Aspire, Inspire and Back Up.
A detailed explanation of SCI² is available @ SCISCI.ac.uk
Scottish Centre for Innovation in Spinal Cord Injury
Glasgow University – NHS, GGC
– NHS Scotland
Queen Elizabeth National Spinal Injury Unit for Scotland
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GU Centre of Rehabilitation Engineering SU Dept of Bioengineering
GU Cellular Neuroscience
Glasgow School of Art, School of Design
School of Health & Life Sciences
Current Areas of Interest
BCI - FES- Control Systems - WBV – Locomotion --Osteoporosis
Primary Intervention – Psychology --OEC Stem Cell–Scaffolds –Pain –Imaging
Public Health
Team Leaders
Professor Manuel Salmerez-Sanchez (GU) Professor Bernie Conway(SU)
Professor Sue Barnett(GU)
John Riddell(GU) Professor Alastair Macdonald(GSA) Adele Dickson (HW)
Mariel Purcell (GGHB) Professor Lorna Paul (GCU)
Participants
NHS GGC Alan McLean Mathew Fraser Mariel Purcell Jon Hasler
David Allan
GU Professor Elizabeth Tanner Henrik Gollee Aleksandra Vuckovic
SU Sylvie Coupaud Helen Berry Heba Lakany
QMU Elaine Coulter
Plasticity Spinal Stimulation Sensors
Stem Cell Implantation
Multi Component Therapy Neural Protection- Neural Repair, Neural Plasticity Repetitive Stimulation and Training
Aberdeen, Edinburgh, EMSCI, Toledo, Balgrist, Sydney
Papers 2018
Vuckovic A, Gallardo V, Jarjees M, Fraser M, Purcell M. Prediction of Central Neuropathic Pain in Spinal Cord Injury Based on EEG. Clinical Neurophysiology. (In review 2018)
2017
Puentes F, Van der Star B, Boomkamp S, Kipp M, Boon L, Raffel J, Gnanapavan S, Van der Valk P, Stephenson J, Barnett S, Baker D, Amor S. Neurofilament Light as an Immune Target for Pathogenic Antibodies. Immunology July 2017 doi:10.111/imm. 12797
Vuckovic A, Al Taleb M, Purcell M, Fraser M. Home used, patient self-managed, brain-computer interface for treatment of central neuropathic pain in spinal cord injury: Feasibilty Study. September 2017. doi:10.3217/978-3 85125-533-1-93 Conference:BC12017, At Graz, Austria
McCaughey E, Borotkanics R, Gollee H, Folz R, McLachlan A. Abdominal functional electrical stimulation to improve respiratory function after spinal cord injury: a systematic review and meta-analysis free. Spinal Cord 55: 798, doi: 10.1038/sc.2017.2
Puentes F, van der Star BJ, Boomkamp SD, Kipp M, Boon L, Bosca I, Raffel J, Gnanapavan S, van der Valk P, Stephenson J, Barnett SC, Baker D, Amor S. Neurofilament light as an immune target for pathogenic antibodies. Immunology. 2017 Jul 17. doi:10/1111/imm.12797 Epub ahead of print
Gollee H, Gawthrop P, Lakie M, Loram I. Visuo-manual tracking: does intermittent control with aperiodic sampling explain linear power and non remnant without sensorimotor noise? Journal of Physiology Aug 2017 doi:10.1113/jp274288
Vuckovic A, Jarjees M, Purcell Berry H, M, Fraser M. Electroencephalographic Predictors of Neuropathic Pain in Subacute Spinal Cord Injury. Journal of Pain. (In submission)
Okoroafor F, Purcell M, Mathieson C. Impressive neurological recovery following C-spine dislocation in a patient with long term immunosuppression. British Journal of Neurosurgery. (in submission)
Meng L, Porr B, Gollee H. Technical developments of functional electrical stimulation to restore gait functions: sensing, control strategies and current commercial systems. Chinese Journal of Scientific Instrument. 6 (6) 1319-1334 July 2017
Osuagwu B, Zych M, Vuckovic A. Is implicit motor imagery a reliable strategy for a brain computer interface? IEEE Transactions on Neural Systems and Rehabilitation Engineering. PP(99(:1-1 June 2017 doi: 10.1109 TNSRE.2017.2712707
Hulme C, Brown S, Fuller H, Riddell J, Osman A, Chowdhury J, Kumar N, Johnson W, Wright K.
The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood. Spinal Cord (2017)55, 114-125; doi:10.1038/sc2016.174; published online 20 December 2016
Berry H, Tate RJ, Conway B.
Transcutaneous spinal direct current stimulation induces lasting fatigue resistance and enhances explosive vertical jump performance. doi:10.1371 journal.pone 0173846
Barnett S, Lindsay S, Ahmed M, Emraja M, Griffin J, Riddell J, Toft A.
Human olfactory mesenchymal stromal cell transplants promote remyelination and earlier improvement in gait co-ordination after spinal cord injury. GLIA 2017;65-65:639-656. doi:10.1002/glia. 23117
Augestad I, Nyman A, Costa A, Barnett S, Sandvig A, Haberg A, Sandvig I.
Effects of neural stem cell and olfactory ensheathing cell co-transplants on tissue remodelling after transient focal cerebral ischemia in the adult rat. Neurochem Res, 2017 Jan 24. doi: 10.1007/s11064-016-2098-3.
Dickson A, Karatzias T, Filmer A, Grandison G, Allan D, Flowers P. Negotiating boundaries of care following spinal cord injury: an interpretative phenomenological analysis. Psychology and Health Journal (in submission)
Papers 2016
Osuagwu B, Wallace L, Fraser M, Vuckovic A. Rehabilitation of hand in subacute tetraplegic patients based on brain computer interface and functional electrical stimulation: a randomised pilot study. J Neural Eng 2016 doi:10.1088/1741-2560/13/6/065002
McCaughey E, Borotkanics R, Gollee H, Folz R, McLachlan A.
Abdominal functional electrical stimulation to improve respiratory function after spinal cord injury: a systematic review and meta-analysis. Spinal Cord September 2016. doi:10.1038/sc2016.70
Allan D, Fairlie-Clarke K, Elliott C, Schuh C, Barnett S, Lassmann H, Linnington C, Jiang H. Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system. Acta Neuropathol Commun. 2016 Jul 26; doi: 10.1086/s40478-016-0344-1
Hasan M, Fraser M, Conway B, Allan D, Vuckovic A.
Reversed cortical over-activity during movement imagination following neurofeedback treatment
Clinical Neurophysiology. doi: 10.1016/jclinph 2016.06.12
Coupaud S, Gislason M, Purcell M, Sasagawa K, Tanner E. Patient-specific bone mineral density distribution in the tibia of individuals with chronic spinal cord injury, derived from multi-slice peripheral Quantitative Computed Tomography (pQCT) J.Bone December 16 doi:10.1016/j.bone.2016.12.014
Lindsay SL. Barnett SC. Are nestin-postive mesenchymal stromal cells a better source of cells for CNS repair? Neurochemistry International.
O’Neill P, Lindsay SL, Pantiru A, Guimond S, Turnbull JE, Verhaagen J, Fagoe N, Riddell JS, Barnett SC. Sulfatase mediated manipulation of the astrocyte-Schwann cell interface. J Neuroscience. doi: 10/1022/glia23047
Kiray H, Lindsay SL, Hosseinzadeh S, Barnett SC. The multifaceted role of astrocytes in regulating myelination. doi: 10.1016/j.expneurol.2016.03.009
Lindsay SL, Johnstone SA, McGrath, Mallinson D, Barnett SC. Comparitive miRNA-based fingerprinting reveals biological differences in human olfactory mucosa and bone marrow-derived mesenchymal stromal cells. Stem Cell Reports doi:
McCaughey E, Allan D B, Purcell M, Barnett S.
Spinal cord injuries caused by stab wounds: Incidence, natural history and relevance to future research. Journal of Neurotrauma 2016 Aug: doi: 10.1089/neu2015 4375 Epub 2016 March 18
Jarjees M, Vuckovic A.
The Effect of Voluntary Modulation of the Sensory-Motor Rhythm During Different Mental Tasks on H Reflex. Int J Psycholphysiol. doi: 10 1016 jipsycho 2016.06.005 Epub 2016 Jun 15
Coulter E, Paul L, McLean A, Hasler J, Allan DB, McFadyen A.
The effectiveness and satisfaction of web-based physiotherapy in people with spinal cord injury: a pilot randomised controlled trial. doi: 10.1038/sc2016.125
Papers 2015
Hasan M.A. Fraser M, Conway B.A. Allan D.B. Vuckovic A. (2015) The mechanism of neurofeedback training for treatment of central neuropathic pain in paraplegia: A Pilot Study BMC Neurology. Doi:10/1186/s12883-015-0445-7 Oct 2015
Osuagwa BCA, Wallace L, Fraser M, Vuckovic A. (2015) Brain-computer interface and functional electrical stimulation for neurorehabilitation of hand in sub-acute tetraplegic patients functional and neurological outcomes. In proceedings of 3rd Int cong on Neurotechnology Electronix and Informatix, NEUROTECHNIX 2015, Lisbon, November 2015 pp15-23. doi:10.5220/0005650500150023
McCaughey E, McLean A, Allan D, Gollee H.
Abdominal Functional Electrical Stimulation to enhance mechanical insufflation-exsufflation.
Journal of Spinal Cord Medicine. Doi:10/1080/10790268. 2015 1114226
Gislason MK, Coupaud S, Fogg Q, McNally S, Purcell M, Sasgawa K, Tanabe Y, Tanner KE.
Validation of Finite Element models predicting fracture in the osteoporotic tibia. Proc. of the 25th Congress of the International Society of Biomechanics (Glasgow UK) July 2015 (conference paper)
Varzi D, Coupaud S, Purcell M, Allan DB, Gregory JS. Barr RJ.
Bone morphology of the femur and tibia captured by statistical shape modelling predicts rapid bone loss in acute spinal cord injury patients. doi:10:1016. Bone Vol 81, pp495-501 (2015)
Wheeler G, Macdonald A.S, Purcell M, Diagrammatic exploration as a bridge between observation and intervention in design and healthcare research. Proceedings of the 3rd European Conference on Design4 Health 2015, Sheffield Hallam University. Available at:
McCaughey E, Purcell M, McLean A, Fraser M, Allan D B, Bewick A.
Changing demographics of spinal cord injury over a 20 year period: A longitudinal population based study in Scotland. doi:10:1038/sc2015. 167. Available at
McCaughey E, Berry H.R, McLean A.N, Allan D.B, Gollee H. “Abdominal Functional Electrical Stimulation to assist ventilator weaning in acute tetraplegia: A cohort study.” Critical Care. Published July 2015 doi:10:1371 journal.pone.0128589
Vuckovic A, Hasan M A, Osuagwu B, Fraser M, Allan D B, Conway B A, Nasseroleslami B.(2015)
The influence of central neuropathic pain in paraplegic patients on performance of a motor imagery based brain computer interface. Clinical Neurophsiology. doi:10.1016/j.clinph 2014.12.033
Johnstone SA, Liley M, Dalby MJ, Barnett SC.
Comparison of human olfactory and skeletal MSCs using osteogenic nanotopography to demonstrate bone-specific bioactivity of the surfaces.
Acta Biomater. 2015 Feb, 13:266-76. doi:10.1016/j.actbio.201411.027. Epub 2014 Nov 21
Coupaud S, McLean A.N, Purcell M, Fraser M.H, Allan D. B. “Decreases in bone mineral density at cortical and trabecular sites in the tibia and femur during the first year of spinal cord injury.” Bone Jan 2015. 74C:69-75.doi:10.1016
Papers 2014
Wheeler G, Macdonald A, Purcell M. Defining and Using Experience Goals to Enhance Patient Agency In Spinal Cord Injury Rehabilitation
Dickson A, Duffy L, Allan D.B. “Adjustment and coping in ventilator dependant patients following a traumatic spinal cord injury; an interpretive phenomenological analysis”. 14 Jun;15(6):645-55. doi: 10.1016/j.jpain.2014.02.005. Epub 2014 Mar 1
Hasan M.A, Vuckovic A, Fraser M, Conway B, Nasseroleslami B, Allan D.B. Reduced activation at the cortical level following neurofeedback treatment is associated with reduction in central neuropathic pain intensity. 6th International Brain-Computer Interface Conference, 16-19th September 2014, Graz University of Technology, Austria
Osuagwu B.A, Vuckovic A, Fraser M, Wallace L, Allan D.B. BCI-FES hand therapy for patients with sub-acute tetraplegia. 6th International Brain-Computer Interface Conference, 16-19th September 2014 Graz University of Technology, Austria
Nasserolami B, Lakany H, Conway B.A. EEG Signatures of Arm Isometric Exertions in Preparation, Planning and Execution. (In eng). Neuroimage 90 Apr 2014. P1-14. doi:10.1061
MacLeod C.A, Meng L, Conway B.A, Porr B. “Reflex Control of Robotic Gait Using Human Walking Data.” PLos ONE 9, No 10, (2014): e109959
Vuckovic Aleksandra, Hasan Muhammad Abdul, Fraser Mathew, Conway Bernard A, Nasseroleslami Bahman, Allan David B., “Dynamic Oscillatory Signatures of Central Neuropathic Pain in Spinal Cord Injury” Journal of Pain 2014 Jun;15(6):645-55. doi: 10.1016/j.jpain.2014.02.005. Epub 2014 Mar 1
D. Hansom, C. Mathieson, M. Purcell, and D. MacDonald, "Acute longitudinal ligament rupture following acute spinal trauma," Emergency Care Journal; vol 10:1903, 2014. doi:10.4081
McCaughey, E.J., McLachlan, A.J., Gollee, H., 2014. Non-intrusive real-time breathing pattern detection and classification for automatic abdominal functional electrical stimulation. Medical Engineering & Physics 36, 1057–1061. doi:10.1016/j.medengphy.2014.04.005
Fang J, Vuckovic A, Galen S, Cossar C, Conway BA, Hunt KJ. Design and evaluation of a prototype gait orthosis for early rehabilitation of walking. Technol Health Care. 2014 Jan 1;22(2):273-88.doi:10.3233/THC-140821
Fang J, Galen S, Vuckovic A, Conway BA, Hunt KJ. Kinetic analysis of supine stepping for early rehabilitation of walking. Proc Inst Mech Eng H. Jan 14;228(5):456-464. doi:10.1177
Fang J, Vuckovic A, Galen S, Conway BA, Hunt KJ. Foot trajectory approximation using the pendulum model of walking. Med Biol Eng Comput. 2014 Jan;52(1):45-52. doi:10.1007/s11517-013-1117-7.Epub 2013 Sep 21. Erratum in: Med Biol Eng Comput. 2014 May;52(5):509
Xu R, Jiang N, Vuckovic A, Hasan M, Mrachacz-Kersting N, Allan D, Fraser M, Naseroleslami B, Conway B, Dremstrup K, Farina D. Movement-related cortical potentials in paraplegic patients: abnormal patterns and considerations for BCI-rehabilitation. Front. Neuroeng.,27 August 2014. doi:10.3389/fneng.2014.00035
Vuckovic A, Wallace L, Allan D B. “Hybrid Brain Computer Interface and Functional Electrical Stimulation for Sensorimotor Training of Sub-acute Tetraplegic Patients” Journal of Neurological Physical Therapy. Jun 15(6):645-55. doi:10.1016/j.pain.2014.02.005. Epub 2014 Mar 1
Vuckovic A, Hasan M A, Fraser M, Conway B A, Nasseroleslami B, Allan D B, “ Motor Imagery in Spinal Cord Injury with Neuropathic Pain: A Component Clustering Method Con Paper ISBN: 978-1-4503-0913-4 doi 10.1145/2093698.2093866
Galen S.S., Clarke C.J., Mclean, A.N., Allan D.B., Conway B A, “Isometric Hip and Knee Torque measurements as an outcome measure in Robot Assisted Gait Training” Neuro Rehab 2014 doi: 10.3233/NRE-131042
Coupaud S, McLean A.N, Purcell M, Fraser M.H, Allan D.B. “Spatiotemporal patterns of epiphyseal bone loss after spinal cord injury – an investigation using peripheral Quantitative Computed Tomography (pQCT)”. In: Proc. Annual Meeting Bone Research Society; Sheffield, June 2014, P48, p32. doi:10.3389
Gislason M.K, Coupaud S, Sasagawa K, Purcell M.A, Allan D.B, Tanabe Y, Tanner E. “Prediction of risk of fracture in the tibia due to altered bone mineral density distribution resulting from disuse: a finite-element study”. Proc IMechE Part H: J. Eng. Medicine 2014, 228: 165-174 doi: 10.1177/0954411914522438
McCaughey E, McLean A.N, Allan D.B, Gollee H. “Detection of the motor points of the abdominal muscles,” Eur J Appl Physiol, Dec 2014 114(12):2483-9. doi: 10.1007/s00421-014-2966-y. Epub 2014 Aug 12
Ioannidou K, Anderson KI, Strachan D, Edgar JM, Barnett SC Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques. BMC Neurosci. 2014 May 2,15:59. doi:10.1186/1471-2202-15-59
Boomkamp SD, McGrath MA, Houslay MD, Barnett SC.
Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
Br J Pharmacol. 2014 May; 171(9):2385-98. doi:10.1111/bph.12588
Donoghue PS, Sun T, Gadegaard N, Riehle MO, Barnett SC Development of a Novel 3D Culture System for Screening Features of Complex Implantable Device for CNS Repair. .
Mol Pharm, 2014 Jul 7;11(7):2143-50. doi:10.1021/mp400526n
Papers 2013
Lamond R, Barnett SC.
Schwann cells but not olfactory ensheathing cells inhibit CNS myelination via the secretion of connective tissue growth factor.
J Neurosci, 2013 Nov 20;33(47):18686-97. doi:10.1523/JNEUROSCI.3233-13.2013
S. Coupaud, A.N. McLean, S.J. Grant, H.R. Berry and D.B .Allan “A model of incorporating a clinically-feasible exercise test in paraplegic annual reviews: a tool for stratified cardiopulmonary stress performance classification and monitoring” Int. J. Phys. Med. Rehabil. 2013, Issue 1, No. 9, pp 1-9. doi:10.4172/2329-9096
Bernard A. Conway, David B. Allan, Sujay S. Galen
‘Development and validation of a low-cost, portable and wireless gait assessment tool’Catherine A. Macleod, Med Eng & Phys doi: 10.1016/j medengphys.2013.11.011,
Vuckovic Aleksandra, Hasan Muhammad A, Fraser Mathew, Conway Bernie, Allan David B A Pilot Study on Clinical and Neurological Effects of Neurofeedback Training for Treatment of Central Neuropathic Pain Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation Volume 7, 2014, pp 823-831. doi:10.1007/978
Coupaud Sylvie, McLean Alan N, Grant Stanley J, Berry Helen R and Allan David B“A Model for incorporating a Clinically-feasible exercise Test in Paraplegic Annual Reviews: A tool for stratified Cardiopulmonary Stress Performance Classification and Monitoring’ Int J Phys Med & Rehabil Vol 1 Issue 9 2013. doi:10.1472
McLachlan, Angus J.; McLean, Alan N.; Allan, David B.; Gollee, H. “Changes in pulmonary function measures following a passive abdominal functional electrical stimulation training program” Journal of Spinal Cord Medicine MAR 2013 Volume: 36 Issue: 2 Pages: 97-103. doi:10.1179
Craven C.D., Gollee H., Coupaud S., Purcell M.,P., Allan, D.,B., “Investigation of robotic-assisted tilt-table therapy for early-stage spinal cord rehabilitation” J Rehab Res Dev 2013;50(3): Pages 367 – 378
Lindsay,S.L.,Johnston,S.A.,Mountford,J.C.,Sheikh,S.,.Allan,D.B.,Clark,L.and Barnett, S.C. 2013 “Human mesenchymal stem cells isolated from olfactory biopsies but not bone enhance CNS myelination in vitro” Glia,61(3).pp368-382 ISSN 0894-1491(doi:10.1002/glia.22440)
Macdonald, A.S. 2013 “The Inner Resource: enabling the designer within us all – a case study” The Design Journal Vol16,Issue 2 pp175-196
Campbell E.,Design and Rehabilitation ................
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