Possible Side Effects of EPOCH (Etoposide, Prednisone ...



Possible Side Effects of EPOCH (Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin) (Table Version Date: July 28, 2022)COMMON, SOME MAY BE SERIOUSIn 100 people receiving EPOCH (Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin), more than 20 and up to 100 may have:High blood pressure which may cause headaches, dizziness, blurred visionInfection, especially when white blood cell count is lowAnemia which may cause tiredness, or may require blood transfusionsBruising, bleedingBlood in urineSwelling of the body, tiredness, bruisingIn children and adolescents: decreased heightNausea, vomiting, diarrhea, loss of appetite, pain in bellyConstipation, which may be severe, as a result of a bowel blockageIncreased appetite and weight gain in the belly, face, back and shouldersSores in mouth or throat which may cause difficulty swallowingAbsence of menstrual period which may decrease the ability to have childrenLoss of bone tissueMuscle weakness and difficulty walkingNumbness and tingling of fingers or toesHeadache, jaw pain and/or muscle painDifficulty sleepingMood swingsSwelling of lower legsSwelling and redness at the site of the medication injection or area of previous radiationRed colored urine, saliva, or sweatHair loss, skin changes, rash, change in nailsOCCASIONAL, SOME MAY BE SERIOUSIn 100 people receiving EPOCH (Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin), from 4 to 20 may have:Heart failure or heart attack which may cause shortness of breath, swelling of ankles, cough or tiredness which may occur years after the doseAbnormal heartbeatFluid around the heartHigh blood pressure which may cause headaches, dizziness, blurred visionLow blood pressure which may cause feeling faintDamage to the lungs or scarring of the lungs which may cause shortness of breathBlood clot which may cause swelling, pain, shortness of breathKidney damage which may cause swelling, may require dialysisDifficulty emptying the bladder or urinating, excessive, frequent, or painful urinationSwelling of the body including the brain which may cause dizziness, confusionParalysisDamage to the bone marrow (irreversible) which may cause infection, bleeding, may require transfusionsDiabetesCloudiness of the eye, visual disturbances, blurred vision with chance of blindnessGlaucomaA tear or a hole in the bowels which may cause belly pain or that may require surgeryHeartburnDamage, loss or absence of sperm which may lead to an inability to father childrenDehydrationAllergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throatDamage to the bone which may cause joint pain and loss of motionNumbness and tingling of the arms, legs, and upper bodyDifficulty with balance and hearingWeight lossDarkening of the gumsDrooping eyelids, abnormal eye movementHoarsenessNon-healing woundRARE, AND SERIOUSIn 100 people receiving EPOCH (Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin), 3 or fewer may have:Sinusoidal obstructive syndrome (SOS) which may cause damage to the liver, yellowing of eyes and skin, and swellingSeizureComaVisual loss with a chance of blindnessBleeding from sores in the stomachA new cancer (including leukemia) resulting from treatment of a prior cancerStevens-Johnson syndrome which may cause severe skin rash with blisters and peeling which can involve mouth and other parts of the bodyBroken bones ................
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