Original research Short term, high-dose vitamin D supplementation for ...
Postgrad Med J: first published as 10.1136/postgradmedj-2020-139065 on 12 November 2020. Downloaded from on October 7, 2022 by guest. Protected by copyright.
Original research
Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)
Ashu Rastogi,1 Anil Bhansali,1 Niranjan Khare,2 Vikas Suri,2 Narayana Yaddanapudi,3 Naresh Sachdeva,1 G D Puri,3 Pankaj Malhotra 2
Supplemental material is published online only. To view please visit the journal online ( postgradmedj-2020139065). 1Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India 2Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India 3Anaesthesia, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Correspondence to Pankaj Malhotra, Department Of Internal Medicine, Nehru Hospital, PGIMER, Chandigarh 160012, India; malhotrapankaj@hotmail. com
All the authors had access to the data and were involved in writing the manuscript as per ICMJE criteria.
Received 19 September 2020 Revised 19 October 2020 Accepted 29 October 2020
? Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
To cite: Rastogi A, Bhansali A, Khare N, et al. Postgrad Med J Epub ahead of print: [please include Day Month Year]. doi:10.1136/ postgradmedj-2020139065
ABSTRACT Background Vitamin D has an immunomodulatory role but the effect of therapeutic vitamin D supplementation in SARS-CoV-2 infection is not known. Aim Effect of high dose, oral cholecalciferol supplementation on SARS-CoV-2 viral clearance. Design Randomised, placebo-controlled. Participants Asymptomatic or mildly symptomatic SARS-CoV-2 RNA positive vitamin D deficient (25(OH) D50 ng/ml (intervention group) or placebo (control group). Patients requiring invasive ventilation or with significant comorbidities were excluded. 25(OH)D levels were assessed at day 7, and cholecalciferol supplementation was continued for those with 25(OH)D 50 ng/ml by day-7 and another two by day-14 [day-14 25(OH)D levels 51.7 (48.9 to 59.5) ng/ml and 15.2 (12.7 to 19.5) ng/ml (p50 ng/ml in 75% of participants by day-14.
Therapeutic, high-dose cholecalciferol supplementation led to SARS-CoV-2 RNA negative in additional 41.7% participants (p ................
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