Agonist & Antagonist Actions
Apomorphine is a dopaminergic agonist. At very low doses, apomorphine has a son noradrenergic autoreceptors) and decreases dopamine release (behaviorally, it produces sedation). But at most doses apomorphine's postsynaptic action on dopamine receptors dominates, so it produces behavioral stimulation similar to amphetamine and cocaine. ................
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