Imperial College London
Activated monocytes/macrophages in kidney biopsies of ANCA GN stain positive for TNFα and IL-1 (33). Both of these cytokines were demonstrated to mediate glomerular damage in experimental models of crescentic GN, where disease was prevented or halted by means of IL-1 receptor antagonists (69, 70) or TNFα blockade (71). ................
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