Drug-Induced Hepatotoxicity
is a tricyclic related drug and therefore has cautions similar to the TCAs [13]. Trazodone is extensively metabolised by the CYP450 pathway to active metabolites which are renally excreted [20,35]. In general, doses do not need to be reduced in RI but it is advisable to start with a low dose and increase the dose cautiously [4,5,35]. ................
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