β-blockers in Heart Failure
The dose of carvedilol used in COMET achieved a similar reduction in heart rate as seen in U.S. Carvedilol (i.e., 13 beats per minute). The mean dose of immediate-release metoprolol tartrate used in COMET was less than the mean dose in MDC (i.e., 85 vs. 108 mg per day), and resulted in less of … ................
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