Cough CER Final (3) Main Report



Table F-3. KQ 2—Study characteristicsStudyIntervention comparison(s)Geographic LocationCough/Population DescriptionIncluded DiseasesNumber of PatientsStudy QualityCass, 195379Antitussive (opiates) vs. Antitussive (other) vs. PlaceboU.S.Persistent coughNR69FairCass, 195480Antitussive (opiates) vs. Antitussive (other) vs. PlaceboU.S.Persistent coughNR65PoorCass, 195681Antitussive (opiates) vs. Antitussive (other) vs, Antitussive (other) PlaceboU.S.Persistent coughNR63FairSimon, 195782Antitussive (anesthetics) vs. Antitussive (anesthetics)U.S.Chronic asthmatic bronchitis/pulmonary emphysema COPD59PoorSimon, 196083Antitussive (anesthetics) vs. Antitussive (opiates) vs. PlaceboU.S.Chronic asthmatic bronchitis/pulmonary emphysemaChronic bronchitis, pulmonary emphysema45PoorWoolf, 196459Antitussive (opiates) vs. PlaceboCanadaChronic coughChronic bronchitis, emphysema10PoorVakil, 196684Antitussive (other) vs. PlaceboAsiaChronic coughChronic bronchitis, TB70FairSevelius, 197185Antitussive (opiates) vs. Antitussive (opiates) vs. PlaceboU.S.Chronic cough secondary to obstructive emphysema and chronic bronchitis COPD12FairWojcicki, 197586Antitussive (other) vs. Protussive (expectorants) vs. PlaceboEuropeCough and nocturnal paroxysms of coughingChronic bronchitis, cystic fibrosis, TB32GoodLilienfield, 197687Antihistamine vs. AntihistamineU.S.NRChronic bronchitis, cystic fibrosis, sarcoidosis, histoplasmosis13FairMatts, 197788Antitussive (other) vs. Protussive (expectorants)UKChronic cough.Post viral infection50FairSabot, 197789Antitussive (opiates) vs. Antitussive (opiates) vs. PlaceboEuropeChronic coughNR24FairClarke, 197990Protussive (mucolytic) vs. Protussive (mucolytic)UKChronic bronchitisChronic bronchitis11GoodDierckx, 198191Antitussive (opiates) vs. Antitussive (other) vs. PlaceboEuropeChronic coughAsthma, chronic bronchitis, cystic fibrosis, TB38FairDiwan, 198292Antitussive (anesthetics) vs. Antitussive (opiates)AsiaChronic coughCOPD, chronic bronchitis, TB60FairMatthys, 198393Antitussive (opiates) vs. Antitussive (other) vs. PlaceboEuropeChronic cough secondary to pulmonary TB, bronchial cancer, or obstructive lung diseaseTB, bronchial cancer, obstructive lung disease16FairGastpar, 198494Antitussive (opiates) vs. Antitussive (other)EuropeCough secondary to upper respiratory tract diseaseNR90PoorJackson, 198495Protussive (mucolytic) vs. PlaceboUKChronic bronchitisChronic bronchitis121PoorRuhle, 198496Antitussive (other) vs. Antitussive (other) vs. PlaceboEuropeChronic coughCOPD, asthma, chronic bronchitis, TB24FairGuyatt, 198797Protussive (mucolytic) vs. PlaceboCanadaChronic productive coughChronic bronchitis78Fairvan Hengstum, 198898Protussive (nonpharmacological) vs. Protussive (nonpharmacological)EuropeChronic bronchitis Chronic bronchitis8FairReid, 198999Antihistamine vs. PlaceboAustralia/ New ZealandChildren, chronic recurrent cough and/or wheeze with evidence of airway hyperreactivityAsthma189FairDueholm, 1992100Protussive (mucolytic) vs. PlaceboUKChronic bronchitis Chronic bronchitis51FairHolmes, 1992101Anticholinergic vs. PlaceboAustralia/ New ZealandPersistent cough secondary to prior upper respiratory tract infectionPost-viral URTI13Goodvan Asperen, 1992102Antihistamine vs. PlaceboAustralia/ New ZealandChildren, chronic cough and/or wheeze Unexplained cough112GoodAversa, 1993103Antitussive (other) vs. PlaceboEuropeChronic lung diseaseCOPD, unexplained cough, neoplasm, pulmonary fibrosis73FairDel Donno, 1994104Antitussive (other) vs. Antitussive (other)EuropeDry or slightly productive coughCOPD, unexplained cough, acute or unspecified bronchitis, other respiratory disease99GoodBarnabe, 19953Antitussive (opiates) vs. Antitussive (other)EuropeDry or slightly productive coughCOPD, unexplained cough, neoplasm, pulmonary fibrosis113FairParvez, 1996105 Study 1Protussive (expectorants) vs. PlaceboAsiaChronic productive cough secondary to bronchopulmonary diseaseCOPD, cystic fibrosis60GoodParvez, 1996105 Study 2Protussive (mucolytic) vs. PlaceboAsiaChronic productive cough secondary to bronchopulmonary diseaseCOPD, cystic fibrosis24GoodTanaka, 1996106Antihistamine vs. PlaceboAsiaChronic coughUACS17FairLuporini, 1998107Antitussive (opiates) vs. Antitussive (other)EuropePersistent, nonproductive cough Lung cancer124FairAliprandi, 2004108 Study 1Antitussive (other) vs. Antitussive (other)EuropeChronic nonproductive cough secondary to chronic bronchitis, bronchial asthma, COPD or medication.COPD, asthma, chronic bronchitis50PoorAliprandi, 2004108 Study 2Antitussive (other) vs. Antitussive (other)EuropeChronic nonproductive cough secondary to chronic bronchitis, bronchial asthma, COPD or medication.COPD, asthma, chronic bronchitis60FairAliprandi, 2004108 Study 3Antitussive (other) vs. Antitussive (other)EuropeChronic nonproductive cough secondary to chronic bronchitis, bronchial asthma, COPD or medication.COPD asthma, chronic bronchitis40FairAliprandi, 2004108 Study 4Antitussive (opiates) vs. Antitussive (other)EuropeChronic nonproductive cough secondary to chronic bronchitis, bronchial asthma, COPD or medication.COPD, asthma, chronic bronchitis120FairAliprandi, 2004108 Study 5Antitussive (opiates) vs. Antitussive (other)EuropeChronic nonproductive cough secondary to chronic bronchitis, bronchial asthma, COPD or medication.COPD, chronic bronchitis60FairAliprandi, 2004108 Study 6Antitussive (other) vs. Antitussive (other)EuropeChronic nonproductive cough secondary to chronic bronchitis, bronchial asthma, COPD or medication.Cough “of varying origin,” ACE inhibitor cough120FairChaudhuri, 2004109Corticosteroid vs. PlaceboUKChronic coughGERD, asthma, UACS, bronchiectasis, eosinophilic bronchitis, bronchitis88FairSmith, 200654Antitussive (opiate) vs. PlaceboUKCOPD with coughCOPD19FairVertigan, 2006110Antitussive (nonpharmacological) vs. PlaceboAustralia/ New ZealandChronic cough GERD, asthma, UACS, ACE inhibitor87FairMorice, 200740Antitussive (opiates) vs. PlaceboUKChronic coughUnexplained cough27PoorRibeiro, 200749Corticosteroid vs. PlaceboS. AmericaChronic coughUnexplained cough64GoodRamsay, 2008111Antitussive (other) vs. PlaceboUKChronic coughNone42GoodWei, 2010112Bronchodilator vs. BronchodilatorAsiaNon- or mildly productive coughCough variant asthma; GERD, nonasthmatic eosinophilic bronchitis;UACS214FairYousaf, 2010113Antibiotic vs. PlaceboUKChronic coughUnexplained cough30GoodMukaida, 2011114Antitussive (other) vs. PlaceboAsiaChronic cough secondary to COPDCOPD19FairMarchant, 2012115Antibiotic vs. PlaceboAustralia/ New ZealandChildren, chronic coughNR50GoodAbbreviations: ACE=angiotensin-converting enzyme; COPD=chronic obstructive pulmonary disease; GERD=gastroesophageal reflux disease; NR=not reported; TB=tuberculosis; UACS=upper airway cough syndrome; URTI=upper respiratory tract infection ................
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