Unboiling an Egg: Novel Approaches to Characterize Prion ...
PrP* is thought to be the state that PrP exists in before it refolds to either an aggregate or native form. It may be a structural “missing link’ that could offer some key insights into how to prevent PrPsc formation. PrP* has been studied by CD and other low-resolution spectroscopic methods [21,22,41] but it has not been studied by NMR or by computational MD simulations. PrP* (or variants ... ................
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