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ALAN SOLOMON: CURRICULUM VITAE

Title: American Cancer Society Clinical Research Professor

Professor of Medicine and Head, Human Immunology & Cancer Program

University of Tennessee Graduate School of Medicine, Knoxville, TN

Birth Date: May 16, 1933

Citizenship: United States (born New York, NY)

Wife: Andrea G. Cartwright

Children: David A. Solomon

Joseph A. Solomon

Step Children: William (Woody) Cartwright

Michael A. Cartwright

Office: University of Tennessee Graduate School of Medicine

1924 Alcoa Highway

Knoxville, TN 37920

Tel: (865)·305·9167

Fax: (865)·305·6865

E-mail: asolomon@utmck.edu

Home: GATOP

2705 Riverside Drive

Knoxville, TN 37914

Tel: (865) 524-5087

Fax: (865) 523-3627

E-mail: asolomonmd@

Education: Bucknell University 1949-1953 Lewisburg, PA BS (Biology)

Duke University School of Medicine 1953-1957

Durham, NC BSM, MD

Military Status: Senior Assistant Surgeon, USPHS 1960-1962

Senior Surgeon, Inactive Reserve, USPHS 1962-1983

Board

Certification: Diplomat: National Board of Medical Examiners 1958

Diplomat: American Board of Internal Medicine 1964

Medical Licensure (active): Tennessee 1966-

Grants and

Awards: Special Fellowship 1963-1965

National Institute of Arthritis and Metabolic Diseases

National Institutes of Health, USPHS

USPHS Research Grant R01 CA-08354 1965-1966

Principal Investigator

American Cancer Society Research Grant T-420 1967-1973

Principal Investigator

National Science Foundation Research Grant GB-6036 1967-1973

Principal Investigator

Research Career Development Award CA-21229 1968-1972

National Cancer Institute

USPHS Research Grant R01 CA-15173 1974-1977

Co-Principal Investigator

American Cancer Society Research Grant IM-430 1985-1991

Principal Investigator

USPHS Research Grant R01 CA-10056 1966-2012

Principal Investigator

American Cancer Society Clinical 1992-2003

Research Professorship

USPHS Research Grant R21 CA-76630 1998-2000

Principal Investigator

USPHS Research Grant R21 CA-82609 1999-2001

Principal Investigator

USPHS (NCI) Rapid Access to Intervention 1999-2000

Development (RAID) Biologic Projects Award 049

Honors: Alpha Omega Alpha 1956

Duke University School of Medicine

C.V. Mosby Award for Scholastic Excellence 1957

Duke University School of Medicine

First Prize, Essay for Fourth Year Medical Students 1957

New England Journal of Medicine

Dr. Daniel Stats Memorial Award 1961

Editorial Board, Journal of the Mount Sinai Hospital

Fellow, American College of Physicians 1968

Second Prize, Henry L. Moses Award 1970

Montefiore Hospital, NY

Physician's Recognition Award 1971

American Medical Association

Third Prize, Henry L. Moses Award 1972

Montefiore Hospital, NY

President's Club 1981

University of Tennessee

The Davison Club 1981

Duke University School of Medicine

First Prize, Henry L. Moses Award 1983

Montefiore Hospital, NY

Laszlo Memorial Lecturer 1984

Montefiore Hospital, NY

The Founders' Society 1987

Duke University

Professor of Medicine Citation in Recognition 1989

of Extraordinary Leadership and Service

University of Tennessee Medical Center

Who's Who in America, 4th Edition 1995

Second Prize (Clinical Category), 2000

Henry L. Moses Award

Montefiore Hospital, NY

First Prize (Clinical Category) 2001

Henry L. Moses Award

Montefiore Hospital, NY

Excellence and Leadership in Basic Science and 2005

Research Award

University of Tennessee Graduate School of Medicine

First Prize (Basic Science Category)

Henry L. Moses Award

Montefiore Hospital, NY 2009

Professional

Organizations: American Federation for Clinical Research 1962-1996

American Association for Cancer Research 1963-

New York County and State Medical Societies 1963-1966

American Medical Association 1963-1995

Society for the Study of Blood 1964-1966

American Society of Hematology 1964-

American Association for Advancement of Science 1965-

Central Society for Clinical Research 1967-1990

American College of Physicians (Fellow) 1967-

American Association of Immunologists 1968-

Knoxville Academy of Medicine 1968-

Tennessee Medical Association 1968-

Sigma Xi 1968-1980

Southern Society for Clinical Investigation 1968-1978

American Society for Clinical Investigation 1971-

American Association for Cancer Education 1977-1982

American Society of Clinical Oncology 1977-

International Society of Hematology 1980-1998

International Society for Experimental Hematology 1981-1995

Clinical Immunology Society 1988-2000

American Society for Investigative Pathology 2002 -

Professional

Assignments

Since 1966: Tutor, Immunology Seminar 1968

University of Tennessee-

Oak Ridge Graduate School of Biomedical Sciences

Institutional Research Grant Committee 1968-1970

American Cancer Society, University of Tennessee

Faculty Council 1968-1975

University of Tennessee Memorial Research Center

Transfusion Committee 1969-1972

University of Tennessee Memorial Research Center

and Hospital

Library Committee 1970-1972

University of Tennessee Memorial Research Center

and Hospital

Southeastern Cancer Study Group 1970- 1980

Regional Representative, Admissions Committee 1970-1991

Duke University School of Medicine

Subcommittee on Nomenclature of 1971-1973

Human Immunoglobulins

International Union of Immunologic Societies

Chairman 1971-1974

Institutional Research Grant Committee

American Cancer Society

University of Tennessee Memorial Research Center

Seminar Chairman 1971-1974

University of Tennessee Memorial Research Center

Graduate Faculty 1971-1988

Department of Microbiology

Subcommittee on Multiple Myeloma 1971-1980

Southeastern Cancer Study Group

Project Coordinator 1972-1974

East Tennessee Cancer Research Center

Special Medical Committee 1973-1974

Comprehensive Health Planning,

Knoxville Academy of Medicine

Consulting Staff (Hematology/Oncology) 1974-1978

East Tennessee Chest Disease Hospital

Research Participation Committee 1974-1977

University of Tennessee-Knoxville

President 1974-1977

Knoxville-Oak Ridge Associated Researchers and

Clinicians in Cancer

Board of Directors 1974-1996

American Cancer Society - Knox County Unit

Professional Education Committee 1974-1990

American Cancer Society - Knox County Unit

Membership Committee 1974-1977

American Association of Immunologists

Secretary 1974-1977

Scientific Review Committee

East Tennessee Cancer Research Center

Chairman 1975-1977

Liaison Committee to the East Tennessee Cancer

Research Center, Knoxville Academy of Medicine

Subcommittee on Tumor Immunology 1975-1978

Southeastern Cancer Study Group

Continuing Medical Education Committee 1975-1978

Knoxville Academy of Medicine

Clinical Cancer Committee 1975-1980

University of Tennessee Medical Center at Knoxville

Consultant 1976-1983

Human Cancer Diagnostics and Therapeutics Unit,

Cancer and Toxicology Program, Biology Division,

Oak Ridge National Laboratory

Medical Director 1977-2004

Baptist Regional Cancer Center

Baptist Hospital of East Tennessee

Chairman 1977-1990

Oncology Committee

Baptist Regional Cancer Center

Consultant 1977-

Center for Mechanistic Biology and Biotechnology

Argonne National Laboratory

Advisory Panel 1978-1980

The American Board of Medical Laboratory Immunology

Research Committee 1978-1979

Tennessee Heart Association

Consultant 1978-1979

Clinical Cancer Program Project Review Committee

National Cancer Institute

National Institutes of Health

Credentials Committee, Medical Staff 1978-1980

East Tennessee Baptist Hospital

Treasurer 1979-1980

Knoxville Society of Internal Medicine

Clinical Cancer Program Project Review Committee 1979-1982

National Cancer Institute

National Institutes of Health

Chairman 1982-1983

Program Project Review Committee

National Cancer Institute

National Institutes of Health

Institutional Review Committee 1979-1982

East Tennessee Baptist Hospital

Special Committee on Blood Banks 1980-1982

Knoxville Academy of Medicine

Committee on Medicine and Religion 1980-1982

Knoxville Academy of Medicine

Consultant 1980-1983

Health and Safety Research Division

Nuclear Division, ORNL

Ad Hoc Subcommittee on Program Project Review 1982-1983

National Cancer Advisory Board

Board of Scientific Counselors 1993-1995

Division of Cancer Biology, Diagnosis, and Centers

National Cancer Institute, National Institutes of Health

Advisory Board 1991-2002

University of Tennessee Research Corporation

Professional Advisory Board 1993-2000

The Wellness Community—National

Editorial Board 1993-

Amyloid: The Journal of Protein Folding Disorders

AAI Committee on Public Affairs 1993-1995

American Association of Immunologists

Cancer Center Program Strategic Planning Task Force 1994-1995

University of Tennessee Medical Center

Knoxville, TN

Counselor 1997-2001

The Henry Kunkel Society,

Rockefeller University Hospital

New York, NY

`

Scientific Advisory Board, 1998-

International Myeloma Foundation

Research Targeting Advisory Group, 1998

American Cancer Society

Harry & Elsa Jiler American 1998-2002

Cancer Society International Visiting

Scientist Committee, Chairman

University of Tennessee Graduate School of Medicine

Scientific Advisory Board 2000-2004

Multiple Myeloma Research Foundation

Medical Advisory Board 2004-

Amyloidosis Research Foundation

Invited Participation in Scientific

Conferences

since 1992: Mechanisms in B-Cell Neoplasia Conference 4/21-23/92

sponsored by the National Cancer Institute's Laboratory

of Genetics, Division of Cancer Biology, Diagnosis and Centers

Bethesda, MD

Site-Visit Chairman, National Cancer Institute 4/29-30/92

Special Review Committee, Clinical Cancer Program Project Grant,

Bethesda, MD

American Cancer Society Cancernet Support Group 5/12/92

Park West Hospital

Knoxville, TN

83rd Annual Meeting of the American Association 5/20-23/92

for Cancer Research

San Diego, CA

25th Annual Meeting and Exposition, The American 11/15-18/92

Society of Nephrology

Baltimore, MD

Methodist Medical Center Staff and CME Committee 4/13/93

Oak Ridge, TN

Introductory Speaker, VII International Symposium 7/11-15/93

on Amyloidosis

Kingston, Ontario, Canada

IVth International Workshop on Multiple Myeloma 10/2-5/93

Mayo Foundation

Rochester, MN

Molecular Approaches to Cancer Immunotherapy, 11/7-11/93

American Association for Cancer Research

Asheville, NC

Markey Cancer Center Seminar Series, 11/12/93

Chandler Medical Center,

Lexington, KY

5th International Conference on Lymphocyte 2/4-6/94

Activation and Immune Regulation

Newport Beach, CA

Conference on Immunoglobulin Gene Expression 7/13-17/94

in Development and Disease, sponsored by

The New York Academy of Sciences

Montreal, Quebec, Canada

36th Annual Meeting and Exposition, 12/3-5/94

The American Society of Hematology

Nashville, TN

9th International Congress of Immunology, 7/23-29/95

San Francisco, CA

Session Chairman on "Major Amyloidoses", 8/20-25/95

FASEB Summer Research Conference on

"Amyloid and Other Abnormal Assembly Processes"

Copper Mountain, CO

Vth International Workshop on Multiple Myeloma 9/10-13/95

La Baule, France

Guest Lecturer commemorating the retirement of 3/23/96

Shiro Saito, MD, Dean and Professor of Medicine,

First Department of Internal Medicine,

School of Medicine,

The University of Tokushima, Japan

The Louisiana State University Medical Center 4/1/96

Seminar Series

Shreveport, LA

American Cancer Society Cancernet Support Group 4/16/96

Knoxville, TN

Internal Medical Ground Rounds, 4/18/96

University of Arkansas for Medical Sciences

Little Rock, AR

The Henry Kunkel Society Meeting 5/2-3/96

The Rockefeller University

New York, NY

VI International Workshop on Multiple Myeloma 6/14-18/97

Boston, MA

FASEB Summer Research Conference on 7/13-18/97

"Amyloid and Other Abnormal Assembly Processes"

Copper Mountain, CO

Center for the Study of Emerging Diseases, 11/8-12/98

International Workshop on Conformational Diseases,

Ein-Boqeq, Dead Sea, Israel

ACS Professors Meeting 10/10/99

White Planes, NY

FASEB Summer Research Conference on 6/11-15/00

“Amyloid and Other Protein Assembly Processes”

Copper Mountain, CO

Henry Kunkel Society Meeting 5/2-3/01

Rockefeller University

New York, NY

VIIIth International Myeloma Workshop 5/4-8/01

Banff, Alberta, Canada

IX International Amyloid Symposium 7/15-21/01

Budapest, Hungary

FASEB Summer Research Conference on 6/15-19/02

“Amyloids and Other Protein Assembly Processes”

Snowmass, CO

9th Conference on Cancer Therapy with Antibodies 10/24-26/02

and Immunoconjugates

Princeton, NJ

ACS Professor Meeting 10/30-11-1/03

Key Biscayne, FL

X International Amyloid Symposium 4/18-22/04

Tours, France

Protein Folding Disorders & Protein Therapeutics 1/11-12/05

San Diego, CA

Presentations

(Since 1991): “Human Light-Chain-Associated Diseases: 3/26/91

Myeloma (Cast) Nephropathy, Light-Chain

Deposition Disease, and Amyloidosis”

Medical Grand Rounds

University of Tennessee Medical Center

“Multiple Myeloma: Recent Advances in 1/16/92

Diagnosis and Treatment”

Cancer Committee Multidisciplinary Conference

University of Tennessee Medical Center

“Malignant Lymphoma” 5/12/92

American Cancer Society-Cancernet Group

Park West Hospital, Knoxville, TN

“Experimental Model of Human Light-Chain- 11/16/92

Associated Renal and Systemic Diseases”

25th Annual Meeting and Exposition

The American Society of Nephrology

Baltimore, MD

“Multiple Myeloma: Diagnosis and Treatment” 4/13/93

Methodist Medical Center Staff and CME Committee

Oak Ridge, TN

“Research Being Conducted in The Human 6/29/93

Immunology & Cancer Program at UTMC/K”

Board of Directors

American Cancer Society Knox County Unit

Knoxville, TN

“Heavy-Chain-Associated Amyloidosis 7/11-15/93

(AH Amyloidosis)”

VIIth International Symposium on Amyloidosis

Kingston, Ontario, Canada

“Multiple Myeloma and Related Diseases: 11/12/93

Clinical and Pathologic Implications of Monoclonal Immunoglobulins”

Markey Cancer Center Seminar Series

University of Kentucky Chandler Medical Center

Lexington, KY

“Plasma Cell Neoplasms and Amyloidosis” 1/21/94

Medical Residents Conference

University of Tennessee Medical Center

Knoxville, TN

“Immunoglobulin Pathophysiology in 4/16/94

B-Cell Malignancies”

American Cancer Society Research Professors' Meeting

Santa Cruz, CA

“Clinical Implications of Light-Chain Deposition” 9/13/94

Medical Grand Rounds

University of Tennessee Medical Center

Knoxville, TN

“Update on Light-Chain-Related Diseases” 11/18/94

Medical Residents Conference

University of Tennessee Medical Center

Knoxville, TN

“Light-Chain Amyloidosis and Deposition Diseases” 8/22/95

FASEB Summer Research Conference on

"Amyloid and Other Abnormal Assembly Processes"

Copper Mountain, CO

Poster: “Immunoglobulin Kappa Light Chain 8/20-25/95

Framework One (FR1) Peptide is Fibrillogenic”

Co-authored with Th. A. Niewold, C. Murphy, and J. Wood,

FASEB Summer Research Conference on

"Amyloid and Other Abnormal Assembly Processes"

Copper Mountain, CO

Poster: “Quantitation and Characterization of 8/20-25/95

the Binding of Thioflavin T (THT) and

Congo Red (CR) to Peptide Fibrils”

Co-authored with J. S. Wall, Th. A. Niewold, and C. Murphy,

FASEB Summer Research Conference on

"Amyloid and Other Abnormal Assembly Processes"

Copper Mountain, CO

“Pathologic Ramifications of Immunoglobulin 9/12/95

Deposition in Multiple Myeloma and Related Diseases”

Vth International Workshop on Multiple Myeloma

La Baule, France

“Human Light-Chain-Associated Renal and 10/24/95

Systemic Diseases: Myeloma (Cast) Nephropathy,

Light-Chain Deposition Disease, and AL Amyloidosis”

Medicine Grand Rounds

University of Tennessee Medical Center

Knoxville, TN

“Multiple Myeloma” 11/10,17/95

Healthline, Channel 12

Knoxville, TN

“Clinical and Experimental Features of the Human 3/23/96

Renal and Systemic Light-Chain-Associated Diseases”

Guest Lecture commemorating the retirement of Shiro Saito, MD

Dean and Professor of Medicine

First Department of Internal Medicine

School of Medicine

The University of Tokushima, Japan

“Clinical and Experimental Features of the Human 4/1/96

Renal and Systemic Light-Chain-Associated Diseases”

The Louisiana State University Medical Center Seminar Series

Shreveport, LA

“Facts About Leukemia, Lymphoma, 4/16/96

Multiple Myeloma, and Hodgkin's Disease-1995 Update”

American Cancer Society Cancernet Support Group

Knoxville, TN

“Clinical and Experimental Features of the Human 4/18/96

Renal and Systemic Light-Chain-Associated Diseases”

Internal Medical Grand Rounds

University of Arkansas for Medical Sciences,

Little Rock, AR

“Clinical and Experimental Features of the Human 5/2/96

Renal and Systemic Light-Chain-Associated Diseases”

The Kunkel Society Meeting

The Rockefeller University

New York, NY

“The Role of Aredia (Pamidronate) in Multiple 9/11/96

Myeloma and Metastatic Lytic Lesions”

Chiron Therapeutics

Knoxville, TN

"Clinical and experimental features of the Human 2/17/97

Renal and Systemic Light-Chain-Associated Diseases"

Guest Lecturer, Neuroscience Therapeutics Seminar

Parke-Davis

Ann Arbor, MI

”Myeloma Update” 4/16-19/98

Arizona Cancer Center

Tucson, AZ

"Comparison of Recombinant λ6 VL Proteins- 8/7 -11/98

Chemical and Thermal Stability Correlates with Fibrillogenesis Potential"

VIII International Symposium on Amyloidosis

Mayo Clinic

Rochester, MN

“Light Chain-Associated Conformational Diseases” 10/8-12/98

International Workshop on Conformational Diseases

The Center for the Study of Emerging Diseases

Ein-Boqeq, Israel

“Light Chain-Associated Conformational Diseases” 1/27/99

Advances in Immunology

University of Tennessee Medical Center

Knoxville, TN

“Immunotherapy in Patients with Light Chain 6/99

Associated (AL) Amyloidosis: Antibody-Mediated

Resolution of Pathologic Deposits”

Development Therapeutic Program

Division of Cancer Treatment and Diagnosis

National Cancer Institute

Frederick, MD

“Advances in the Diagnosis and Treatment 8/30/99

of Amyloid-Associated Diseases: Collaboration between

the Universities of Uppsala and Tennessee”

Guest Lecturer

Uppsala University

Uppsala, Sweden

Poster: “Extramedullary Production of 9/1-5/99

AL Amyloid Precursor Proteins”

VIIth International Workshop on Multiple Myeloma

Stockholm, Sweden

“Antibody-Mediated Resolution of Light Chain- 6/11-15/00

Associated (AL) Amyloid Deposits”

FASEB Summer Research Conference on “Amyloid and Other

Protein Assembly Processes”

Copper Mountain, CO

“Primary (AL) Amyloidosis: Diagnostic, Prognosis 7/15-21/01

and Therapeutic Strategies”

Keynote Lecturer

IXth International Symposium on Amyloidosis

Budapest, Hungary

“Primary (AL) Amyloidosis: Diagnostic, Prognostic, 8/17/01

and Therapeutic Strategies”

Department of Pathology

University of Tennessee Medical Center, Knoxville

Knoxville, TN

“Immunotherapy of Patients with Primary (AL) 4/3/02

Amyloidosis: Antibody-Mediated Resolution of

Pathologic Deposits”

Drug Development Group

Division of Cancer Treatment and Diagnosis

National Cancer Institute

Rockville, MD

“Primary Amyloidosis” 7/30/02 Department of Medicine Grand Rounds

University of Tennessee Medical Center, Knoxville

Knoxville, TN

“Immunotherapy in Primary (AL) Amyloidosis using 8-24-02

Amyloid-Reactive Monoclonal Antibodies”

Guest Lecturer

9th Conference on Cancer Therapy with Antibodies and

Immunoconjugates

Princeton, NJ

“Amyloid: The Curse of Old Age” 9-26-03

University of Tennessee Science Forum

University of Tennessee

Knoxville, TN

“The Amyloidoses: A Medical Curse “ 10-26-03

Council of Scientific Writers

Knoxville, TN

“Amyloid-Reactive Antibodies as Novel 10-30-03

Immunotherapeutic Agents for Patients with Primary

(AL) Amyloidosis”

American Cancer Society Professors Meeting

Key Biscayne, FL

“Immunotherapy in Systemic Primary (AL) Amyloidosis 2-25-04

using Amyloid-Reactive Monoclonal Antibodies”

Forum, University of Tennessee Department of

Biochemistry Molecular Biology

Knoxville, TN

“Immunotherapy in AL Amyloidosis” 4-21-04

Xth International Symposium on Amyloid and Amyloidosis

Tours, France

“Amyloid-Reactive Antibodies as Novel 10-26-04

Immunotherapeutic and Imaging Agents for

Patients with Primary (AL) Amyloidosis”

Hematology/Medical Oncology Grand Rounds

Memorial Sloan-Kettering Cancer Center

New York, NY

“Demonstration of the Efficacy of Passive 1-11-05

Immunotherapy of Peripheral Amyloid Diseases in

Animal Models”

San Diego, CA

“War on Amyloid: Diagnostic and Therapeutic 4-11-06

Strategies”

Internal Medicine Ground Rounds

The University of Tennessee Graduate School of Medicine

Knoxville, TN

Appointments: Intern 1957-1958

Mount Sinai Hospital, NY

Assistant Resident in Medicine (Dr. L. Leiter) 1958-1959

Montefiore Hospital, NY

Assistant Resident in Medicine (Dr. A. B. Gutman) 1959-1960

Mount Sinai Hospital, NY

Clinical Associate 1960-1962

Metabolism Service (Dr. J.L. Fahey)

National Cancer Institute, National Institutes of Health

Chief Resident in Medicine (Dr. A. B. Gutman) 1962-1963

Mount Sinai Hospital, NY

Research Assistant in Hematology 1963-1965

(Dr. L. R. Wasserman)

Mount Sinai Hospital, NY

Guest Investigator (Dr. H. G. Kunkel) and 1963-1965

Assistant Physician

The Rockefeller University, NY

Assistant Attending Hematologist 1965-1966

Mount Sinai Hospital, NY

Associate Physician and Guest Investigator 1965-1966

The Rockefeller University, NY

Associate Research Professor 1966-1969

University of Tennessee Memorial Research Center and Hospital

Knoxville, TN

Research Professor 1970-1978

University of Tennessee Memorial Research Center and Hospital

Knoxville, TN

Clinical Professor 1972-1980

Department of Medicine, Clinical Education Center

University of Tennessee Center for Health Sciences

Knoxville, TN

Professor of Medical Biology 1978-1980

Department of Medical Biology, Memorial Research Center

University of Tennessee Center for Health Sciences

Knoxville, TN

Professor of Medicine 1981- Department of Medicine

University of Tennessee Center for Health Sciences

Knoxville, TN

Head, Human Immunology & Cancer Program 1988- Department of Medicine

University of Tennessee Medical Center

Knoxville, TN

Guest Investigator 1990-

Argonne National Laboratory

Argonne, IL

American Cancer Society Clinical Research Professor 1992-

Hospital Staff Appointments

(Knoxville, TN): Active Medical Staff 1966-

Department of Medicine

University of Tennessee Medical Center

Active Medical Staff 1975-

Department of Medicine (Hematology/Oncology)

Baptist Hospital of East Tennessee

Courtesy Medical Staff 1975-2000

Department of Medicine (Hematology/Oncology)

Fort Sanders Regional Medical Center

Courtesy Medical Staff 1975-1993

Department of Medicine (Hematology/Oncology)

East Tennessee Children's Hospital

Courtesy Medical Staff 1976-1998

Department of Medicine (Hematology/Oncology)

St. Mary's Medical Center

Other Assignments

and Honors: Board of Visitors, College of Nursing 1997-

University of Tennessee

Board of Visitors 2004-

University of Tennessee Department of

Religious Studies

Advisory Board, Clarence Brown Theater 2000-

University of Tennessee

James L. Clayton Award, Knoxville Museum of Art 2007

Knoxville, TN

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