DRUGS CONTRAINDICATED IN PREGNANCY (part 1 of 2)

DRUGS CONTRAINDICATED IN PREGNANCY (part 1 of 2)

This chart represents information on select drugs that are contraindicated (Pregnancy category X) for women who are pregnant. This is not an inclusive list of products that carry that pregnancy category. Those drugs that are contraindicated at a certain phase of the pregnancy are listed next to the product name. For more information on specific drug monographs, see product entries or consult the manufacturer.

ALLERGIC DISORDERS

Vistaril (hydroxyzine) Early pregnancy

CARDIOVASCULAR SYSTEM

Advicor (niacin ext-rel/lovastatin) Aggrenox (dipyridamole/aspirin) 3rd trimester Altoprev (lovastatin) Bayer (aspirin) 3rd trimester Caduet (amlodipine/atorvastatin) Coumadin (warfarin sodium) Crestor (rosuvastatin) Ecotrin (aspirin) 3rd trimester Juvisync (sitagliptin/simvastatin) Lescol (fluvastatin) Lescol XL (fluvastatin) Letairis (ambrisentan) Lipitor (atorvastatin) Livalo (pitavastatin) Mevacor (lovastatin) Multaq (dronedarone) Pravachol (pravastatin) Simcor (niacin ext-rel/simvastatin) Tracleer (bosentan) Vytorin (ezetimibe/simvastatin) Zocor (simvastatin)

CENTRAL NERVOUS SYSTEM

Beyaz (drospirenone/ethinyl estradiol) Doral (quazepam) Estazolam Flurazepam Halcion (triazolam) Restoril (temazepam) Vistaril (hydroxyzine) Early pregnancy Yaz (drospirenone/ethinyl estradiol)

DERMATOLOGICAL DISORDERS

Amnesteem (isotretinoin) Avage (tazarotene) Beyaz (drospirenone/ethinyl estradiol) Carac (fluorouracil) Claravis (isotretinoin) Efudex (fluorouracil) Estrostep Fe (norethindrone acetate/ ethinyl estradiol) Fluoroplex (fluorouracil) Loryna (drospirenone/ethinyl estradiol) Ortho Tri-Cyclen 28 (norgestimate/ ethinyl estradiol) Propecia (finasteride) Silvadene (silver sulfadiazine) Late pregnancy Solage (mequinol/tretinoin) Solaraze (diclofenac sodium) 3rd trimester Soriatane (acitretin) Sotret (isotretinoin)

SSD (silver sulfadiazine) Late

Macrodantin (nitrofurantoin

pregnancy SSD AF (silver sulfadiazine) Late

macrocrystals) Pregnancy at term Rebetol (ribavirin)

pregnancy

Rebetron (ribavirin/interferon alfa -2b)

Tazorac (tazarotene)

Septra (sulfamethoxazole/trimethoprim)

Tilia Fe (norethindrone acetate/ethinyl 3rd trimester

estradiol)

Sulfadiazine Pregnancy at term

Tri-Legest 21 (norethindrone acetate/ Tindamax (tinidazole) 1st trimester

ethinyl estradiol)

Urobiotic-250 (oxytetracycline HCl/

Tri-Legest Fe (norethindrone acetate/ sulfamethizole/phenazopyridine) Late

ethinyl estradiol)

pregnancy

Tri-previfem (norgestimate/ethinyl

Virazole (ribavirin)

estradiol) Tri-sprintec (norgestimate/ethinyl estradiol) Yaz (drospirenone/ethinyl estradiol)

METABOLIC DISORDERS Zavesca (miglustat) MUSCULOSKELETAL DISORDERS

ENDOCRINE SYSTEM

Androderm (testosterone) Androgel (testosterone) Android (methyltestosterone) Axiron (testosterone) Delatestryl (testosterone enanthate) Depo-testosterone (testosterone cypionate) Egrifta (tesamorelin) Fluoxymesterone Fortesta (testosterone) Juvisync (sitagliptin/simvastatin) Lupron (leuprolide acetate) Methitest (methyltestosterone) Oxandrin (oxandrolone) Striant (testosterone) Supprelin LA (histrelin acetate) Synarel (nafarelin) Testim (testosterone) Testred (methyltestosterone) Virilon (methyltestosterone)

GASTROINTESTINAL TRACT

Bellergal-S (phenobarbital/ergotamine tar trate) Cytotec (misoprostol)

Advil (ibuprofen) 3rd trimester Aleve (naproxen sodium) 3rd trimester Ansaid (flurbiprofen) Late pregnancy Arava (leflunomide) Arthrotec (diclofenac sodium/ misoprostol) Bayer (aspirin) 3rd trimester BC Arthritis Strength (aspirin/caffeine/ salicylamide) 3rd trimester Cataflam (diclofenac potassium) Late pregnancy Celebrex (celecoxib) 3rd trimester Choline magnesium trisalicylate Pregnancy at term Dantrium (dantrolene) Daypro (oxaprozin) 3rd trimester Diclofenac sodium Late pregnancy Diflunisal 3rd trimester Duexis (ibuprofen/famotidine) Late pregnancy (30wks) Ecotrin (aspirin) 3rd trimester Etodolac Late pregnancy Evista (raloxifene HCl) Feldene (piroxicam) Late pregnancy Ketoprofen Late pregnancy Mobic (meloxicam) 3rd trimester Motrin (ibuprofen) 3rd trimester Nabumetone 3rd trimester

INFECTIONS & INFESTATIONS

Nalfon (fenoprofen calcium) 3rd

trimester

Bactrim (sulfamethoxazole/

Naprelan (naproxen) 3rd trimester

trimethoprim) 3rd trimester

Prevacid Naprapac (lansoprazole/

Copegus (ribavirin)

naproxen) 3rd trimester

Flagyl (metronidazole) 1st trimester for Probenecid + Colchicine

trichomoniasis

Prolia (denosumab)

Furadantin (nitrofurantoin) Pregnancy at Rheumatrex (methotrexate sodium)

term

Salsalate 3rd trimester

Gantrisin (sulfisoxazole) 3rd trimester Soma Compound w. Codeine

Grifulvin V (griseofulvin)

(carisoprodol/aspirin/codeine) 3rd trimester

Gris-Peg (griseofulvin)

Vimovo (naproxen/esomeprazole) Late

Macrobid (nitrofurantoin as

pregnancy (30wks)

macrocrystals and monohydrate)

Zipsor (diclofenac potassium) Late

Pregnancy at term

pregnancy

Not an inclusive list.

(continued)

DRUGS CONTRAINDICATED IN PREGNANCY (part 2 of 2)

NEOPLASMS

Flagyl (metronidazole) 1st trimester for Choline magnesium trisalicylate

Bexxar (tositumomab) Casodex (bicalutamide) Delestrogen (estradiol valerate) Efudex (fluorouracil) Eligard (leuprolide acetate) Estrace (estradiol) Evista (raloxifene HCl) Firmagon (degarelix) Fluoxymesterone Menest (esterified estrogens) Revlimid (lenalidomide) Targretin (bexarotene) Thalomid (thalidomide) Trelstar (triptorelan pamoate) Trexall (methotrexate) Vantas (histrelin acetate) Zytiga (abiraterone acetate)

trichomoniasis

Pregnancy at term

Follistim (follitropin beta)

Combunox (oxycodone/ibuprofen) 3rd

Ganirelix acetate

trimester

Gonal-F (follitropin alfa)

D.H.E. 45 (dihydroergotamine

Lupron Depot (leuprolide acetate)

mesylate)

Luveris (lutropin alfa)

Diflunisal 3rd trimester

Menopur (menoptropins)

Etodolac Late pregnancy

Methergine (methylergonovine)

Excedrin Migraine (acetaminophen/

Midol cramp (ibuprofen) 3rd trimester aspirin/ caffeine) 3rd trimester

Midol menstrual (acetaminophen/

Fiorinal (butalbital/aspirin/caffeine)

caffeine/pyrilamine) 3rd trimester

3rd trimester

Midol PMS (acetaminophen/

Fiorinal w. Codeine (butalbital/aspirin/

pamabrom/pyrilamine) 3rd trimester caffeine/codeine phosphate) 3rd

Midol teen (acetaminophen/pamabrom) trimester

3rd trimester)

Ibudone (hydrocodone bitartrate/

Mifeprex (mifepristone)

ibuprofen) 3rd trimester

Motrin (ibuprofen) 3rd trimester)

Ketorolac Late pregnancy

Naprelan (naproxen) 3rd trimester

Migranal (dihydroergotamine

NUTRITION Didrex (benzphetamine)

Ovidrel (choriogonadotropin alfa) Ponstel (mefenamic acid) Late pregnancy

mesylate) Motrin Migraine Pain (ibuprofen) 3rd trimester

Fosteum (genistein/citrated zinc/ cholecalciferol)

Repronex 75 IU (follicle-stimulating hormone/luteinizing hormone)

Nalfon (fenoprofen calcium) 3rd trimester

Megace ES (megestrol acetate)

Repronex 150 IU (follicle-stimulating Naprelan (naproxen) 3rd trimester

Megace Suspension (megestrol acetate) hormone/luteinizing hormone)

Xenical (orlistat)

Serophene (clomiphene citrate)

Percodan (oxycodone HCl/aspirin) 3rd trimester

OB/GYN

Synarel (nafarelin acetate) Tindamax (tinidazole) 1st trimester

Ponstel (mefenamic acid) Late pregnancy

ALL ORAL CONTRACEPTIVES

Zoladex (goserelin)

Synalgos-DC (dihydrocodeine bitartrate/

ALL HORMONE REPLACEMENT THERAPY

PAIN & PYREXIA

aspirin/caffeine) 3rd trimester Vicoprofen (hydrocodone bitartrate/

Advil (ibuprofen) 3rd trimester

Advil (ibuprofen) 3rd trimester

ibuprofen) 3rd trimester

Aleve (naproxen sodium) 3rd trimester Advil Migraine (ibuprofen) 3rd

Aygestin (norethindrone acetate)

trimester

RESPIRATORY TRACT

Betadine douche (povidone-iodine)

Aleve (naproxen sodium) 3rd

None available

Bravelle (urofollitropin)

trimester

Cataflam (diclofenac potassium) Late Bayer (aspirin) 3rd trimester

UROGENITAL SYSTEM

pregnancy

BC Original Formula (aspirin/caffeine/ Avodart (dutasteride HCl) AVOID

Celebrex (celecoxib) 3rd trimester

salicylamide) 3rd trimester

HANDLING CAPSULES

Cetrotide (cetrorelix)

Cafergot (ergotamine tartrate/

Caverject (alprostadil)

Clomid (clomiphene citrate)

caffeine)

Edex (alprostadil)

Depo-subQ provera

Caldolor (ibuprofen) 3rd trimester

Jalyn (dutasteride/tamsulosin HCl)

(medroxyprogesterone acetate)

Cataflam (diclofenac potassium) Late Lithostat (acetohydroxamic acid)

Endometrin (micronized progesterone) pregnancy

Proscar (finasteride) AVOID HANDLING

Ectopic pregnancy

Celebrex (celecoxib) 3rd trimester

CRUSHED/BROKEN TABLETS

Not an inclusive list.

(Rev. 10/2012)

PREGNANCY CATEGORIES

When pregnancy appears as a contraindication or precaution to the use of a drug it is usually qualified by a category.

Cat. A: Adequate studies in pregnant women have failed to show a risk to the fetus in the first trimester and there is no evidence of risk in later trimesters.

Cat. B: Animal studies have failed to show a risk to the fetus but there are no adequate studies in pregnant women; or animal studies have shown an adverse effect but human studies have not shown a risk to the fetus in the first trimester and there is no evidence of risk in later trimesters.

Cat. C: Animal studies have shown an adverse effect on the fetus but there are no adequate studies in humans, but the benefits may outweigh the risks; or there are no adequate human studies.

Cat. D: Positive evidence of human fetal risk but the benefits may outweigh the risks.

Cat. X: Animal or human studies have shown fetal abnormalities or toxicity and the risk outweighs the benefits.

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