National PBM Monograph Template Rev20091005

CrCl Increase in AUC Increase in Cmax Half-life (hrs) 80 ml/min 1 (normal) 1 (normal) 13 50 ml/min 1.5x 1.1x 15 30 ml/min 3.2x 1.7x 18 Patients with moderate hepatic impairment (Child-Pugh B) displayed large inter-subject variability in dabigatran pharmacokinetics, although a consistent effect on pharmacodynamics was not seen.6 ................
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