Protecting our way of life | EPA
Please use this document for guidance on how to provide the filenames for the data included with your application and to confirm what you have provided. This completed document must be submitted along with the main application form for chemical pesticides containing a new active ingredient or for any application with supporting studies.Applicants making an application for a substance other than a chemical pesticide that contains a new active ingredient (e.g. a new veterinary medicine, pure chemical, or biological pesticide), should consult with the EPA with respect to the data requirements needed to support such applications. Name of the substance to be approved FORMTEXT ?????Date FORMTEXT ?????GuidelinesThis document outlines the specific data requirements for approval of a chemical pesticide with a new active ingredient. It is intended to be used as a checklist for applicants to confirm that all data have been provided, and to serve as an index which EPA staff can use to readily identify studies in the supplied dossier. Recommendations for how files should be named are made below, however if you choose to use your own naming system, you must ensure that files are named in a systematic, logical and informative manner. Recommended filenamesFiles should be named as follows: Category_SectionRowNumber_Title_SubstanceType_UniqueIdentifier.pdfWhere: Category: Substance Type: T – Toxicology studies; AI – Active ingredient E – Ecotoxicology studies; F – FormulationEF – Environmental Fate M – Metabolite P – Physico-chemical studies For example: T_3.1_Acute_oral_toxicity_AI_Study1.pdfIf multiple studies are supplied, unique identifiers (such as the laboratory study number OR company study number) must be included at the end of the file name e.g. T_3.2_Genotoxicity_in_vitro_F_bacteria.pdfTo increase process efficiency, after a single unique identifier is selected, please ensure naming consistency throughout all files you may also want to include in the file name the organism name/type used in the study.If a substance has multiple active ingredients, or an active ingredient has multiple metabolites, numbers can be used to differentiate these (e.g. AI1, AI2, M1, M2). Please ensure that you provide the code names for the active ingredients, formulation and metabolites. Conditionally required (CR) studies must be provided if they are already available. If CR studies are not provided, these may be requested by the EPA. Studies should be performed according to GLP (Good Laboratory Practice). Non-GLP studies will be evaluated on a case by case basis.Not all studies and available guidelines are listed below. When studies have been conducted with other test methods, reports of these studies must also be provided to the EPA. Studies have to be performed according to the most recent version of the guideline. General notesPlease note that new studies may not be the only way of meeting the data requirements, but all endpoints that are indicated as ‘required’ must be addressed. If you consider that a study is not required then you must provide a statement to justify why the information is not necessary. This statement should have a logical and informative file name. EPA policy is to minimise the use of animals in mammalian toxicology studies wherever technically and scientifically feasible. You should gather and evaluate all available information before considering further testing. These data include physico-chemical properties, (Q)SAR, read-across, in vitro data, animal studies, and human data. If you want us to read-across information from another (similar) substance then you will need to justify why it is scientifically valid to read across the information. Tests on vertebrate animals should be undertaken only where no other validated methods are available. Alternative methods to be considered include in vitro methods and in silico/(Q)SAR methods. Reduction and refinement methods for in vivo testing are also encouraged to minimise the number of animals used in testing.Toxicological information can be obtained from unpublished studies, databases and publications such as books, scientific journals, criteria documents, monographs and other publications. If you do not own the data that you want to use to support your application, you will need to supply a Letter of Access signed by the owner of the data so that we can use the data to assess your product. You may need a letter of access for reports produced by other regulators such as an EU Draft Assessment Report (DAR).Before you conduct new tests to determine the hazardous properties of a substance, you should assess all the information that is available for that substance. You should also consider the possible effects of components on the toxic potential of the total mixture. You should avoid conducting new in vivo testing with corrosive substances at concentration/dose levels that are known to cause corrosivity. Specific test strategies for skin and eye corrosion/irritation testing are included in the EPA’s User Guide to Thresholds and Classifications under the HSNO Act (t.nz/Publications/ER-UG-03-2.pdf). We encourage you to discuss the need to perform supplementary studies with us before conducting the studies, so that the studies meet our needs. For instance, we can discuss the parameters to be investigated and the objectives to be achieved (for example, for products containing active ingredients or other components suspected of having synergistic or additive toxicological effects).We expect applicants to provide a quantitative risk assessment (modelling) to support their application. In the event that these data are not available, the EPA will use default values for the exposure modelling. Endpoint & Test titleTested “Substance”A.I. - Active ingredient F - Formulation M - Metabolite Code name(A.I., F, M)Required (R) orConditionally Required (CR) Recommended guideline(s)ChecklistFilename(s)Identification1A. Discussion of formation of impuritiesA.I.ROPPTS 830.1670 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????1B. Certified limitsA.I.ROPPTS 830.1750 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????1C. Identity of the active substanceA.I.RWHO/FAO 2010 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Physical/chemical properties2A. ColourA.I. FROPPTS 830.6302 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2B. Physical stateA.I. FROPPTS 830.6303 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2C. OdourA.I. FROPPTS 830.6304 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2D. Self-heatingA.I. FRA.15/A16/Test N.4 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2E. Flammability / Flash pointA.I. FROPPTS 830.6315/A.9/A.10/A.11/ A.12/ Test N.1 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2F. Explosive propertiesA.I. FROPPTS 830.6316/A.14 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2G. pHA.I. FROECD 122/ OPPTS 830.7000/ CIPAC MT 75.3/ CIPAC MT 31/CIPAC MT 191 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2H. Melting pointA.I.ROECD 102/ OPPTS 830.7200 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2I. Boiling point/boiling rangeA.I.ROECD 103/ OPPTS 830.7220 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2J. Density/relative density/bulk densityA.I. FROPPTS 830.7300/ OECD 109/ CIPAC MT 186 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2K. Dissociation constants in waterA.I.ROECD 112/ OPPTS 830.7370 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2L. Partition coefficient (n-octanol/water),A.I.ROECD 107/ OPPTS 830.7550/ OECD 117/ OPPTS 830.7570/ OECD 123 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2M. Water solubilityA.I.ROECD 105/ OPPTS 830.7840 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2N. Vapour pressureA.I.ROECD 104/ OPPTS 830.7950 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????20. Corrosion characteristicsFCROPPTS 830.6320 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2Q. ViscosityFCROECD 114/ OPPTS 830.7100 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2R. Solubility in organic solventsA.I.RCIPAC Method MT 181 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2S. Surface tensionA.I.ROECD 115/Method A.5 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2T. Oxidising propertiesA.I. FRA.17/ A.21/ Test O.1/: Test O.3/ Test O.2 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????2U. Particle size distributionA.I. FCROECD 110/ OPPTS 830.7520/ CIPAC MT 185/ CIPAC MT 187/ CIPAC MT 170/CIPAC MT 187 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Toxicological studiesAcute toxicity3.1A. Acute oral toxicityA.I. FMRRCROPPTS 870.1100/ OECD 401/ OECD 420/ OECD 423/ OECD 425 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.1B. Acute dermal toxicityA.I. FMRRCROPPTS 870.1200/ OECD 402 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.1C. Acute inhalation toxicityA.I. FMRRCROPPTS 870.1300/ OECD 403/ OECD 436 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.1D/ Acute skin irritation/corrosionA.I. FMRRCROPPTS 870.2500/ OECD 404/ OECD 430/ OECD 431/ OECD 435/ OECD 439 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.1E. Acute eye irritationA.I. FMRRCROPPTS 870.2400/ OECD 405/ OECD 437/ OECD 438/ OECD 491/ OECD 492 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.1F. Skin sensitizationA.I. FMRRCROPPTS 798.4100/ OECD 406/ OECD 429/ OECD 442A/ OECD 442B/ OECD 442C/ OECD 442D FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Genotoxicity3.2A. In vitro studiesA.I.MRCROPPTS 870.5100/ OECD 471/OECD 487/ OPPTS 870.5300/ OECD 476/ OECD 490 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.2B. In vivo studies in somatic cellsA.I.MRCROPPTS 870.5395/ OECD 474/ OPPTS 870.5385OECD 475/ OECD 488/ OECD 489 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.2C. In vivo studies in germ cellsA.I. F MCROPPTS 870.5380/ OECD 483/ OECD 478 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Short term toxicity3.3A. Repeated dose 28-day toxicity study in rodentsA.I. FMCROPPTS 870.3050/ OECD 407/ OPPTS 870.3200/ OECD 410/ OECD 412 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.3B. Repeated dose 90-day oral toxicity study in rodentsA.I.MRCROPPTS 870.3100/ OPPTS 712-C-98-199/ OECD 408 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.3C. Repeated dose 90-day oral toxicity study in non-rodentsA.I.MRCROPPTS 870.3150/ OECD 409 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.3D. Repeated dose 90-day inhalation toxicity study in rodentsA.I.MCROPPTS 870.3465/ OECD 413 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.3E. Repeated dose 90-day dermal toxicity study in rodentsA.I. MCROPPTS 870.3250/ OECD 411 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Reproductive and developmental toxicity3.4A. Reproduction/ Developmental Toxicity Screening TestA.I. MCROPPTS 870.3550/ OECD 421 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.4B. Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test A.I. MCROPPTS 870.3650/ OECD 422 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.4C. Prenatal Developmental Toxicity StudyA.I. MRCROPPTS 870.3700/ OECD 414 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.4D. One-Generation Reproduction Toxicity StudyA.I.MRCROECD 415 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.4E. Two-Generation Reproduction ToxicityA.I.MRCROECD 416 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Long term toxicity and carcinogenicity3.5A. Chronic Toxicity/carcinogenicityA.I.MRCROPPTS 870.4200/ OECD 451/ OPPTS 870.4100/ OECD 452/ OPPTS 870.4300/ OECD 453 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Neurotoxicity3.6A. Neurotoxicity studies in rodentsA.I. MCROPPTS 870.6200/ OECD 424 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.6B. Delayed polyneuropathy studiesA.I. MCROPPTS 835.6100/ OECD 418/ OPPTS 835.6100/ OECD 419 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Absorption, distribution, metabolism and excretion3.7A. ToxicokineticsA.I.CROPPTS 870.7485/ OECD 417 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.7B. Dermal absorptionA.I. FMRRCROECD 428/ OECD 427 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????3.7D. The screening and testing of potential endocrine disruptersA.I.MCROECD 455/ OECD 457/ OECD 493 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Exposure monitoringApplicator exposure monitoring4.1A. Dermal exposure - outdoorFROPPTS 875.1100 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????4.1B. Dermal exposure - indoorFROPPTS 875.1200 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????4.1C. Inhalation exposure - outdoorFROPPTS 875.1300 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????4.1D. Inhalation exposure - indoorFROPPTS 875.1300 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????4.1E. Biological monitoringFCROPPTS 875.1500 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Post-application exposure monitoring4.2A. Foliar Dislodgeable Residue DissipationFROPPTS 875.2100 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????4.2B. Soil Residue DissipationFCROPPTS 875.2200 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????4.2C. Dermal ExposureFROPPTS 875.2400 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????4.2D. Inhalation ExposureFCROPPTS 875.2500 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????4.2E. Biological monitoringFCROPPTS 875.2600 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Bystander exposure 4.3A. Dermal ExposureFR FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????4.3B. Inhalation ExposureFR FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????4.3C. Oral ExposureFR FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Transport in environmental mediaMobility in soil5.1A. Adsorption/desorption batch equilibriumA.I. MRCROECD 106/ OPPTS 835.1230 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.1B. Leaching studies in soil columnA.I. MCROECD 312/ OPPTS 835.1240 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.1C. Lysimeter studiesA.I. MCROECD Series on Testing an Assessment No. 22. Guidance Document for the Performance of Out-door Monolith Lysimeter Studies (2000). FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.1D. Field leaching studies A.I. MCR FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Abiotic degradation5.2A. Hydrolysis as function of pHA.I. ROECD 111/ OPPTS 835.2120 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.2B. Photodegradation in water (photolysis)A.I. ROECD 316/ OPPTS 835.2240 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.2C. Photodegradation on soil (photolysis)A.I. ROPPTS 835.2410 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.2D. Photodegradation in airA.I. CROPPTS 835.2370 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Biological degradationBiodegradation in water5.3.1A. Ready biodegradabilityA.I. ROECD 301/ OECD 310/ OPPTS 835.3110/ OPPTS 835.3140 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.1B. Aerobic mineralization in surface water – simulation biodegradation testA.I.MCROECD 309/ OPPTS 835.3190 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.1C. Biodegradability in sea waterA.I. CROECD 306/ OPPTS 835.3160 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.1D. Aerobic aquatic metabolismA.I.MROECD 308/ OPPTS 835.4300 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.1E. Anaerobic aquatic metabolismA.I.MCROECD 308/ OPPTS 835.4400 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.1F. Aquatic (sediment) field dissipationA.I.MCROPPTS 835.6200 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Biodegradation in soil5.3.2A. Inherent biodegradation in soilA.I. MRCROECD 304A/ OPPTS 835.3300 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.2B. Aerobic soil metabolismA.I.M CROECD 307/ OPPTS 835.4100/ ISO 10381-6:2009 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.2C. Anaerobic soil metabolismA.I.MCROECD 307/ OPPTS 835.4200 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.2D. Rate of degradation in soilA.I.MRCRBased on the results of the above mentioned studies FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.2E. Terrestrial field dissipationA.I.MCROPPTS 835.6100 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.2F. Forestry dissipationA.I.MCROPPTS 835.6300 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.2G. Combination and tank mixes (USEPA)FCROPPTS 835.6400 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.3 Bioconcentration/Bioaccumulation studies5.3.3A. Bioaccumulation in FishA.I.CROECD 305 / OCSPP 850.1730 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.3B. Bioaccumulation in Terrestrial OligochaetesA.I.FCROECD 317 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.3.3C. Bioaccumulation in Sediment-dwelling Benthic OligochaetesA.I.FCROECD 315 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Volatility from soil5.4A. Laboratory volatility A.I.MCROPPTS 835.1410 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????5.4B. Field volatilityA.I.MCROPPTS 835.8100 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Ecotoxicological studiesAquatic ecotoxicityShort-term studies6.1.1A. Fish acute toxicity test, freshwater and marineA.I. FMRCROECD 203 / OCSPP 850.1075 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.1B. Fish acute toxicity mitigated by humic acidA.I.MCROPPTS 850.1085 (draft) FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.1C. Fish Embryo Acute Toxicity (FET) TestA.I.MCROECD 236 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.1D. Aquatic invertebrate acute toxicity (freshwater daphnids)A.I. FMRRCROECD 202 / OCSPP 850.1010 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.1E. Gammarid acute toxicity testA.I. F MCROCSPP 850.1020 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.1F. Oyster acute toxicity test (shell deposition)A.I. F MCROCSPP 850.1025 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.1G. Mysid acute toxicity testA.I. F MCROCSPP 850.1035 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.1H. Penaeid acute toxicity testA.I. F MCROCSPP 850.1045 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.1I. Bivalve acute toxicity test (embryo larval)A.I. F MCROCSPP 850.1055 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.1J. Freshwater alga and cyanobacteria growth inhibitionA.I. FMRRCROECD 201 / OCSPP 850.4500 / OCSPP 850.4550 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.1K. Aquatic plant toxicity test using Lemna sppA.I.F MCROECD 221 / OCSPP 850.4400 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Long term studies6.1.2A. Fish life cycle toxicityA.I.MRCROECD 210 / OCSPP 850.1400 / OPPTS 850.1500 (draft) / OECD 212 / OECD 215 / OECD 229 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.2B. Daphnia magna reproduction testA.I.MRCROECD 211 / OCSPP 850.1300 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.2C. Mysid chronic toxicity testA.I.MCROPPTS 850.1350 (draft) FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.2D. Effects on aquatic macrophytesA.I.MCRASTM E1913-04 / OECD 239 / OECD 238 / OCSPP 850.4450 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Other aquatic studies6.1.3A. Generic freshwater microcosm test, laboratoryA.I. F MCROPPTS 850.1900 (draft) FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.3B. Site-specific aquatic microcosm test, laboratoryA.I. FMCROPPTS 850.1925 (draft) FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.3C. Field testing for aquatic organismsA.I. F MCROPPTS 850.1950 (draft) FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.1.3D. Aquatic food chain transferA.I. F MCROPPTS 850.1850 (draft) FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Sediment ecotoxicity6.2A. Sediment-water Chironomid toxicity using spiked sedimentA.I. F MCROECD 218 / OCSPP 850.1735 / OPPTS 850.1790 (draft) FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.2B. Sediment-water Chironomid toxicity using spiked waterA.I. F MCROECD 219 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.2C. Sediment-water Chironomid life-cycle toxicity test using spike water or spiked sedimentA.I. F MCROECD 233 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.2D. Whole sediment acute toxicity invertebrates, marineA.I. FMCROCSPP 850.1740 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.2E. Tadpole/sediment subchronic toxicity testA.I. FMCROPPTS 850.1800 (draft) FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Soil ecotoxicityEarthworms and other invertebrates6.3.1A. Earthworm acute testA.IFMCROECD 207 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.1B. Earthworm subchronic toxicity testA.IFMCROCSPP 850.3100 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.1C. Earthworm reproduction test (Eisenia fetida/Eisenia andrei)A.I.MRCROECD 222 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.1D. Earthworm – field studiesA.I. F MCRISO 11268-3: 2014 Part 3. FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.1E. Enchytraeid reproduction testA.I. F MCROECD 220 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.1F. Predatory mite (Hypolaspis [Geolaelaps] aculeifer) reproduction test in soilA.I. FMCROECD 226 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.1G. Collembolan reproduction test in soilA.I. FMCROECD 232 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.1H. Determination of development toxicity of a test chemical to Dipteran dune fliesA.I. FMCROECD 228 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Microorganisms6.3.2A. Soil microorganism: nitrogen transformation testA.I.F MRCRCROECD 216 / OCSPP 850.3200 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.2B. Soil microorganism: carbon transformation testA.I.F MCROECD 217 / OCSPP 850.3200 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.2C. Soil microbial community toxicity testA.I. FMCROCSPP 850.3200 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Plants6.3.3A. Seedling emergenceA.I.F MCRRCROECD 208 / OCSPP 850.4100 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.3B. Terrestrial plant vegetative vigourA.I.F MCRRCROECD 227 / OPPTS 850.4150 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.3C. Seed germination, root elongationA.I. FMCROPPTS 850.4200 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.3D. Early seedling growthA.I. FMCROCSPP 850.4230 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.3E. Rhizobium-legume toxicityA.I. FMCROCSPP 850.4600 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.3F. Plant uptake and translocation testA.I. F MCROCSPP 850.4800 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.3.3G. Terrestrial plants field studyA.I. F MCROCSPP 850.4300 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Other soil tests6.3.4A. Terrestrials soil-core microcosm testA.I. FMCROCSPP 850.4900 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Terrestrial vertebrates6.4A. Avian acute oral toxicity test (non-dietary)A.IF MRCRCROECD 223 / OCSPP 850.2100 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.4B. Avian reproduction testA.I.FRCROECD 206 / OCSPP 850.2300 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.4C. Field testing for terrestrial wildlifeA.I. FCROCSPP 850.2500 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Terrestrial invertebrates – bees and other beneficial arthropodsEffects on bees6.5.1A. Honey bee acute oral toxicityA.I FMRCRCROECD 213 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.1B. Honey bee acute contact toxicityA.I FMRCRCROECD 214 / OCSPP 850.3020 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.1C. Honey bee toxicity of residues on foliageA.I. F MCROCSPP 850.3030 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.1D. Honey bee larval toxicity test, single exposureA.IF MRCRCROECD 237 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.1E. Honeybee brood feeding testA.I. FMCROECD Series No.75 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.1F. Chronic toxicity to bees A.I. F MRCRCRNo validated guideline available FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.1G. Sub-lethal effects A.I. FMCRNo validated guideline available FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.1H. Cage and tunnel tests A.I. FMCROECD 75 / EPPO 170 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.1I. Field tests with honeybeesA.I. FMCREPPO 170 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.1J. Field testing for pollinatorsA.I. FMCROCSPP 850.3040 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Effects on other beneficial arthropods6.5.2A. Standard laboratory testing for non-target arthropods testing with Aphidius rhopalosiphi and Typhlodromus pyriA.I FMCRRCRM.P. Candolfi, S. Blümel, R. Forster et al. (2000): FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.2B. Extended laboratory testing for non-target arthropods, aged residue studies with non-target arthropodsA.I.FMCRM.P. Candolfi, S. Blümel, R. Forster et al. (2000) NOTEREF _Ref378084265 \h \* MERGEFORMAT 4/ Mead-Briggs, M.A., Moll, M., Grimm, et al (2010). FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.2C. Semi-field studies with non-target arthropodsA.I.FMCRM.P. Candolfi, S. Blümel, R. Forster et al. (2000) FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????6.5.2D. Field studies with non-target arthropodsA.I.FMCRM.P. Candolfi, S. Blümel, R. Forster et al. (2000) NOTEREF _Ref378084333 \h \* MERGEFORMAT 6 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ?????Other concerns6.6A. Endocrine disrupting propertiesA.I.FMCROECD 229/ OECD 231/ OECD 234/ OECD 240/ OECD 24/OCSPP 890.2100 FORMCHECKBOX Data provided FORMCHECKBOX EPA check FORMTEXT ????? ................
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