Textbook:Required textbook:



BIOM 425 and 525: Toxicology: The Basic Science of Poisons, Spring 2015 –Updated Feb 25, 2015Montana State UniversitySplit undergrad/grad courseUpdated: Feb 25, 2015Catalog Data: Spring, 3 cr.This course is appropriate for premed, health professional, and environmental science majors.? Topics include history, principles, and mechanisms of toxicology; disposition of toxicants; chemical carcinogens; target organ toxicity; clinical and environmental toxicology.Prerequisites: CHMY 141--College Chemistry I ???CHMY 143--College Chemistry II ??BIOB 160 - General biologyCo-requisite: Biochemistry?BCH 380 ?Class Schedule: Monday and Wed 1:10 pm-2:25pm beginning 1/14/2015 and ending 5/1/2015Classroom: Mondays in CHVR 214; Wednesday in ROBH 218Course Web Site: D2L is used in this course forNews and class updatesProviding copies of all material handed out in classHomework assignments and solutions (available online right after the assignment due date)In Class Quizzes – 5 pts each x 10 random select days = 50 ptsProviding student access to assignment scores and course gradesTextbook:Required textbook: Casarett & Doull’s Essentials of Toxicology, C.D. Klaassen and J.B. Watkins, 2nd edition, 2010.Additional Resources: Casarett & Doull’s Toxicology: The Basic Science of Poisons, C.D. Klaassen and J.B. Watkins, 8th edition, 2013.Instructor:Deborah E. Keil, Ph.D., MT(ASCP), DABT103 Lewis Hall, deborah.keil@montana.eduOffice Hours: (Mon 2:30-3pm; Wed 2:30-3pm and by appointment)The primary goal of this course is to provide an understanding and knowledge of the mechanisms of toxicity including the role of metabolism in enhancing and reducing toxicity and the effects of toxicants on major organ systems. Students are expected to learn the following fundamental toxicological concepts: major classes of toxicants, absorption, distribution and storage of toxicants, biotransformation and elimination of toxicants, and effects of toxicants on major organ systems. Clinical and environmental agents specific to human health and an introduction to risk assessment of exposure to toxicants will also be discussed. Learning Outcomes: Students will be able toEvaluate the historical use and abuse of toxicological agents and this impact on managing environmental and clinical chemicals present day.Describe the chemical properties and the biological processes that modulate the toxicokinetics of chemicals --- absorption, distribution, metabolism, and excretion.Explain the biological transformation reactions as a determining factor of the toxicokinetic and toxicodynamic activities of chemicals.Describe molecular, cellular and physiological responses resulting from exposure to chemical agents (clinical and environmental) relevant to human health.Identify various classes of compounds (i.e., metals, polyaromatic compounds, solvents etc.) and their primary modes (or mechanisms) of action affecting human health.Identify essential risk factors that contribute to the capability of chemicals to elicit biological effects leading to human disease.Determine the perspective the role of toxicology in the risk assessment process.Recognize all stakeholders involved in a risk assessment and various perspectives they offer to a management decision regarding a toxicological agent.In addition, cognitive, affective and psychomotor skills will be developed and expanded in this course based on course or project assignments.Graduate student criteria:In contrast to undergraduate students, graduate students will be required to:lead informal discussions on assigned toxicology readings in classanswer additional short answer and essay questions on toxicology lecture exams (20 more pts)present a toxicology project – 4 page review on an assigned toxicology topic or case study, with a class presentation. Grading Scale:A 100 94% C+ 79 78%A 93 90% C 77 74% B+ 89 88% C- 73 - 70% B 87 84% D 69 63%B 83 80%F 62 or belowScoring Undergraduates:100 pts. First Exam100 pts. Second Exam100 pts. Third and Final ExamRandom in class quizzes – 5 pts x 10 = 50 ptsTotal Points = 350 pts.Scoring Graduates:120pts. First Exam with essay120pts. Second Exam with essay120 pts. Third and Final Exam with essay40pts – leading informal in-class discussions on assigned toxicology topics100 pts. Project PresentationRandom in class quizzes – 5 pts x 10 = 50 ptsTotal Points = 550 pts.Exam format: ? In class and/or home essays? Final Exam is comprehensive; see the published Final Exam Schedule for time and location? No notes are allowed during exam. When needed, a calculator may be used. This will be indicated by the instructor. ? Any unexcused exam will be assigned 0 points. Official documentation will be required to support any excused absences from exams. Online course guidelines and communication: classroom lecture, email and D2L Electronic or equipment failure: It is your responsibility to maintain your computer and related equipment in order to participate in the online portion of the course and email communication. Equipment failures will not be an acceptable excuse for any late or absent assignments. Document archiving: You are responsible for making sure your assignments, including attachments, are received before the deadline. Naming conventions and software type: When indicated by the instructor, you are responsible for submitting the assignment with the required naming convention, correct file extension, and using the software type and version required for the assignment. Late assignments: For each day an assignment is late, a decrease in a half step letter grade will be applied to the assignment. That is, if the submission is late one day, the grade will drop from A- to a B+ due to the tardiness alone. If two days, then A- will become a B-, and so forth. Classroom equivalency: Discussion threads, e-mails, and chat rooms are all considered to be equivalent to classrooms, and student behavior within those environments shall conform to the Student Code. Specifically: Posting photos or comments that would be off-topic in a classroom are still off-topic in an online posting. Off-color language and photos are never appropriate. Using angry or abusive language is called "flaming", is not acceptable, and will be dealt with according to the Student Code. Do not use ALL CAPS, except for titles, since it is the equivalent of shouting online, as is overuse of certain punctuation marks such as exclamation points !!!! and question marks ?????. Course e-mails, e-journals, and other online course communications are part of the classroom and as such, are University property and subject to GRAMA regulations and the Student Code. Privacy regarding these communications between correspondents must not be assumed and should be mutually agreed upon in advance, in writing. Attendance Policy for Lectures: Attendance is expected. Each session requires active participation and at times evaluation of student presentations and discussions. Attendance will not be monitored, however I will be doing random in class quizzes. One can only be present to get credit. Exceptions: In accordance with the Attendance Policy of Montana State University Student Code, students whose religious obligations, University activities, or other legitimate obligations as determined by the instructor may interfere with their ability to fulfill any course requirements on their scheduled dates shall in advance of those dates arrange with the instructor to fulfill the requirements.Plagiarism: Paraphrasing or quoting another’s work without citing the source is a form of academic misconduct. Even inadvertent or unintentional misuse or appropriation of another's work (such as relying heavily on source material that is not expressly acknowledged) is considered plagiarism. If you have any questions about using and citing sources, you are expected to ask for clarification. Plagiarism Software Policy:The professor and/or instructors of this course may elect to use a plagiarism detection service in this course, in which case you will be required to submit any assignment. It is defined as any of the following:A. Using the words or ideas of another, from the internet or any source, without proper citation of the sources, commonly called plagiarism.B. Receiving external assistance during an examination or any academic exercise for credit unless expressly permitted by the instructor. This includes, but is not limited to:1. Providing or receiving aid not permitted by the instructor in connection with any academic assignment;2. Unauthorized use or possession of camera telephones, text messages, computer disks, audio recorders, calculators, solution materials, photocopies, materials from previous classes, commercial research services, notes or other means to copy or photograph materials used or intended for academic evaluation not authorized by the instructor for use during the academic evaluation nor assignment; 3. Communication in any manner with another student not permitted by the instructor during an examination; 4. Working with others on graded coursework, including in-class, online, and take-home examinations, unless expressly permitted by the instructor; or5. Possessing, reading, buying, selling or using any materials intended for an academic evaluation or assignment in advance of its administration without the knowledge and consent of the instructor.C. Turning in the same work in more than one class (or when repeating a class), unless permission is received in advance from the instructor.D. Falsifying information for inclusion in an assigned paper, project or exercise; including inventing or altering data from a laboratory or field project, or creating fictional citations for a paper.E. Attempting to influence or change any academic evaluation, assignment or academic records for reasons having no relevance to academic achievement. This includes, but is not limited to, bribery, threats and making unauthorized changes to any academic record. F. Falsifying or misrepresenting hours or activities in relationship to an internship, externship, field experience, clinical activity or similar activity.G. Acting or attempting to act as a substitute for another, or using or attempting to use a substitute, in any academic evaluation or assignment.H. Facilitating, permitting or tolerating any of the above-listed items.Special Needs Information:Students with special Needs or requiring special accommodations should contact the instructor and the Disabled Student Services Office at the earliest opportunity. Montana State University to dedicated to providing equal access to its programs, services and activities for people with disabilities. If you will need accommodations in the class, reasonable prior notice needs to be given to the Center for Disability Services.Student Conduct: Montana State University expects all students to conduct themselves as honest, responsible and law-abiding members of the academic community and to respect the rights of other students, members of the faculty and staff and the public to use, enjoy and participate in the University programs and facilities. For additional information reference see www2.montana.edu/policy/student_conduct/student_conduct-code_2008-2009.htm Collaboration: University policy states that, unless otherwise specified, students may not collaborate on graded material. Any exceptions to this policy will be stated explicitly for individual assignments. If you have any questions about the limits of collaboration, you are expected to ask for clarification. Academic Misconduct: Section 420 of the Student Conduct Code describes academic misconduct as including but not limited to plagiarism, cheating, multiple submissions, or facilitating others’ misconduct. Possible sanctions for academic misconduct range from an oral reprimand to expulsion from the university. Academic Expectations: Section 310.00 in the MSU Conduct Guidelines states that students must: A. be prompt and regular in attending classes; B. be well prepared for classes; C. submit required assignments in a timely manner; D. take exams when scheduled; E. act in a respectful manner toward other students and the instructor and in a way that does not detract from the learning experience; and F. make and keep appointments when necessary to meet with the instructor. Course Etiquette: ? Please be punctual to class meetings, especially when presentations are scheduled. Your late arrival may disrupt or distract a speaker. ? Be a constructive audience for your peers. Your role is to help individuals clarify what they are trying to say so that it is clear to you; you don’t need to agree with them. ? When making suggestions or offering comments, be constructive and specific. ? If you eat or drink a beverage, please don’t let this be disruptive. Dates 2014TopicChapters, Assigned Readingand Chapters in Casarett and Doulls, Essentials textbookWeek 1Wed Jan 14History and Introduction of Principles of Toxicology Chapter 1Week 2Mon Jan 19 Wed Jan 21Monday Jan 19 is a holidayPrinciples of ToxicologyChapter 2, Chapter 5 (ADME)Week 3Mon Jan 26 Wed Jan 28Principles of Toxicology and ADMEGuest Speaker – Lead (Pb), Dr. Mari EggersChapter 2, Chapter 5 (ADME)Week 4Mon Feb 2 Wed Feb 4Principles of Toxicology and ADMEChapter 2, Chapter 5 (ADME)Week 5Mon Feb 9Wed Feb 11Principles, Phase I, II, biotransformationWed Feb 11 Exam #1 administered by Lacey MurphyChapter 2, Chapter 5 (ADME)Chapter 6Week 6Mon Feb 16Wed Feb 18Monday Feb 16 is a holidayWed Feb 18 – Ms. Lacey Murphy MS (pending), MT (ASCP)Chapter 6Week 7Mon Feb 23 Wed Feb 25 Grad student presentationsMechanisms of Action/Toxicity Chapter 3Week 8Mon Mar 2Wed Mar 4CarcinogenicityChapter 8Week 9Mon Mar 9 Wed Mar 11Spring Break HolidayWeek 10Mon Mar 16Wed Mar 18Clinical Tox/Pharmacological Agents, Drugs of Abuse Chapter 31 and 32Week 11Mon Mar 23Wed Mar 25Exam #2 Monday March 23No Class Wed March 25 due to Toxicology Conference for Keil and MurphyWeek 12Mon Mar 30Wed Apr 1April 1, guest speaker, Detective Wagner, Gallatin Sheriff’s OfficeImmunotoxicology Chapter 12Week 13Mon Apr 6Wed Apr 8Genetic ToxicologyRisk Assessment Chapter 9, 4Week 14Mon Apr 13Wed Apr 15Food Toxicology (ppts to be prepared)Chapter 30Week 15Mon Apr 20Wed Apr 22Grad Student PresentationsWeek 16Mon Apr 27Wed Apr 29Catch up day or PresentationsExam #3 Wed Apr 29Final Exam Week May 4-8; Graduation Saturday May 9 ................
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