Practical tips for warfarin dosing and monitoring

has a relatively short half-life. On the other hand, the antithrombotic effect (the body’s ability to prevent further thrombus formation) may not be achieved for up to 5 days. This effect depends on the clearance of circulating prothrombin, which, as we said, has an elimination half-life of about 60 hours. Therefore, although higher starting ... ................
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